Ensembl_Gene_ID,evidence_pass,evidence_status,failure_reasons,positive_evidence_inside,rna_routine_missing,ihc_routine_missing,ihc_coverage,vital_rna_max_ntpm,protected_rna_max_ntpm,rna_exclusions,ihc_exclusions,ihc_forbidden_contexts_observed,absence_evidence,tissue_review_status,tissue_review_flags,tissue_review_contexts,Symbol,scenario,retained,family_eligible,nomination_review_eligible,nomination_review_reason,source_dois,source_publications,previous_retained,previous_evidence_pass,previous_rna_exclusions,previous_ihc_exclusions,previous_failure_reasons,change
ENSG00000000460,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,8.9,13,"parathyroid gland: 13 nTPM (protected, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); retina: 5.3 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FIRRM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"parathyroid gland: 13 nTPM (protected, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); retina: 5.3 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000001631,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,12.4,15.8,"parathyroid gland: 15.8 nTPM (protected, limit 7.5); tongue: 13 nTPM (protected, limit 5); thyroid gland: 12.6 nTPM (protected, limit 7.5); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 5); urinary bladder: 8.4 nTPM (protected, limit 7.5); adrenal gland: 8.4 nTPM (vital, limit 3); liver: 8.1 nTPM (vital, limit 3); adipose tissue: 8 nTPM (protected, limit 7.5); pancreas: 7.9 nTPM (vital, limit 3); stomach: 7.9 nTPM (protected, limit 7.5); esophagus: 7.7 nTPM (protected, limit 7.5); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KRIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 15.8 nTPM (protected, limit 7.5); tongue: 13 nTPM (protected, limit 5); thyroid gland: 12.6 nTPM (protected, limit 7.5); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 5); urinary bladder: 8.4 nTPM (protected, limit 7.5); adrenal gland: 8.4 nTPM (vital, limit 3); liver: 8.1 nTPM (vital, limit 3); adipose tissue: 8 nTPM (protected, limit 7.5); pancreas: 7.9 nTPM (vital, limit 3); stomach: 7.9 nTPM (protected, limit 7.5); esophagus: 7.7 nTPM (protected, limit 7.5); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",appendix / enterocytes: Low (Supported); colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000004809,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,20.2,3.7,"bone marrow: 20.2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SLC22A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,False,False,"bone marrow: 20.2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000004838,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,82.5,3.6,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZMYND10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000005175,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,22,28.9,"lymph node: 28.9 nTPM (protected, limit 5); tongue: 22.7 nTPM (protected, limit 5); skeletal muscle: 22 nTPM (vital, limit 1); parathyroid gland: 16.7 nTPM (protected, limit 5); urinary bladder: 16.3 nTPM (protected, limit 5); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (protected, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 5); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 5); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 5); stomach: 10.8 nTPM (protected, limit 5); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RPAP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 28.9 nTPM (protected, limit 5); tongue: 22.7 nTPM (protected, limit 5); skeletal muscle: 22 nTPM (vital, limit 1); appendix: 18.5 nTPM (protected, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 5); urinary bladder: 16.3 nTPM (protected, limit 5); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (protected, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 5); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 5); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 5); gallbladder: 11.7 nTPM (protected, limit 5); stomach: 10.8 nTPM (protected, limit 5); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000005189,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,11.4,38.6,"parathyroid gland: 38.6 nTPM (protected, limit 5); bone marrow: 11.4 nTPM (vital, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,REXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"parathyroid gland: 38.6 nTPM (protected, limit 5); bone marrow: 11.4 nTPM (vital, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); colon / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000005889,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,29.2,14.9,"bone marrow: 29.2 nTPM (vital, limit 1); parathyroid gland: 14.9 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (protected, limit 5); tongue: 12 nTPM (protected, limit 5); lymph node: 11.3 nTPM (protected, limit 5); thyroid gland: 10.4 nTPM (protected, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 5); urinary bladder: 8.8 nTPM (protected, limit 5); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.7 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZFX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 29.2 nTPM (vital, limit 1); parathyroid gland: 14.9 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (protected, limit 5); tongue: 12 nTPM (protected, limit 5); lymph node: 11.3 nTPM (protected, limit 5); thyroid gland: 10.4 nTPM (protected, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 5); urinary bladder: 8.8 nTPM (protected, limit 5); heart muscle: 8.5 nTPM (vital, limit 1); appendix: 8.5 nTPM (protected, limit 5); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.7 nTPM (vital, limit 1); gallbladder: 6.7 nTPM (protected, limit 5); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); appendix / glandular cells: Low (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000006047,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.9,7,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,YBX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000006059,True,compatible,,True,0,6,partial,0,0.9,,,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,KRT33A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000006459,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,16.2,12.7,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); rectum: 9 nTPM (protected, limit 5); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 5); duodenum: 8 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); esophagus: 6.7 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 5); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,KDM7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); rectum: 9 nTPM (protected, limit 5); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 5); duodenum: 8 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); appendix: 6.7 nTPM (protected, limit 5); esophagus: 6.7 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 5); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000006634,True,compatible,,True,0,80,unavailable,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DBF4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000006659,True,compatible,,True,0,80,unavailable,0.5,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LGALS14,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000006837,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.2,3.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CDKL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000007038,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,7.7,1.4,"bone marrow: 7.7 nTPM (vital, limit 5); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRSS21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,False,False,"bone marrow: 7.7 nTPM (vital, limit 5); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000007174,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,13,3.5,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 5); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,DNAH9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 5); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000007350,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,3.7,0.5,"retina: 2.1 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,TKTL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"retina: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000008256,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,27.6,27.9,"adipose tissue: 27.9 nTPM (protected, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (protected, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 5); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 5); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 5); stomach: 13.5 nTPM (protected, limit 5); urinary bladder: 13.4 nTPM (protected, limit 5); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 5); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,CYTH3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 27.9 nTPM (protected, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (protected, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 5); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 5); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 5); stomach: 13.5 nTPM (protected, limit 5); urinary bladder: 13.4 nTPM (protected, limit 5); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); gallbladder: 11.4 nTPM (protected, limit 5); parathyroid gland: 11.1 nTPM (protected, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 5); appendix: 5.2 nTPM (protected, limit 5); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000009335,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,63.3,56.3,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 5); parathyroid gland: 35 nTPM (protected, limit 5); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 5); urinary bladder: 27.1 nTPM (protected, limit 5); adipose tissue: 24.8 nTPM (protected, limit 5); rectum: 22.5 nTPM (protected, limit 5); liver: 22.3 nTPM (vital, limit 1); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 5); lymph node: 20.5 nTPM (protected, limit 5); stomach: 20.4 nTPM (protected, limit 5); small intestine: 20.3 nTPM (vital, limit 1); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (protected, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,UBE3C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 5); parathyroid gland: 35 nTPM (protected, limit 5); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 5); urinary bladder: 27.1 nTPM (protected, limit 5); adipose tissue: 24.8 nTPM (protected, limit 5); rectum: 22.5 nTPM (protected, limit 5); liver: 22.3 nTPM (vital, limit 1); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 5); appendix: 21 nTPM (protected, limit 5); lymph node: 20.5 nTPM (protected, limit 5); stomach: 20.4 nTPM (protected, limit 5); small intestine: 20.3 nTPM (vital, limit 1); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); gallbladder: 18.5 nTPM (protected, limit 5); lung: 18.4 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (protected, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000010072,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,11.7,6.2,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); esophagus: 5.5 nTPM (protected, limit 5); tongue: 5.1 nTPM (protected, limit 5); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SPRTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); esophagus: 5.5 nTPM (protected, limit 5); tongue: 5.1 nTPM (protected, limit 5); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000010318,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,4.6,5.5,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PHF7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000011590,False,excluded,positive_ihc_outside_permitted,True,0,6,partial,1.6,3.3,,bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZBTB32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000013573,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,28.8,12.9,"bone marrow: 28.8 nTPM (vital, limit 1); pancreas: 17 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 5); stomach: 9.3 nTPM (protected, limit 5); colon: 9.3 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 5); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,DDX11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 28.8 nTPM (vital, limit 1); pancreas: 17 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); skeletal muscle: 10.3 nTPM (vital, limit 1); appendix: 9.9 nTPM (protected, limit 5); rectum: 9.7 nTPM (protected, limit 5); stomach: 9.3 nTPM (protected, limit 5); colon: 9.3 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 5); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); gallbladder: 5.7 nTPM (protected, limit 5); adipose tissue: 5.7 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000013810,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,55.5,39,"bone marrow: 55.5 nTPM (vital, limit 1); lymph node: 39 nTPM (protected, limit 5); esophagus: 14.4 nTPM (protected, limit 5); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 5); colon: 9.6 nTPM (protected, limit 5); lung: 6.3 nTPM (vital, limit 5); smooth muscle: 6 nTPM (vital, limit 5); duodenum: 5.9 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,TACC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 55.5 nTPM (vital, limit 1); lymph node: 39 nTPM (protected, limit 5); appendix: 22.6 nTPM (protected, limit 5); esophagus: 14.4 nTPM (protected, limit 5); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 5); colon: 9.6 nTPM (protected, limit 5); lung: 6.3 nTPM (vital, limit 5); smooth muscle: 6 nTPM (vital, limit 5); duodenum: 5.9 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000020256,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.3,6.9,"parathyroid gland: 6.9 nTPM (protected, limit 5); esophagus: 6.8 nTPM (protected, limit 5); thyroid gland: 6.6 nTPM (protected, limit 5); lymph node: 6.4 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); stomach: 5.7 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZFP64,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 6.9 nTPM (protected, limit 5); esophagus: 6.8 nTPM (protected, limit 5); thyroid gland: 6.6 nTPM (protected, limit 5); lymph node: 6.4 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); stomach: 5.7 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); rectum: 5.4 nTPM (protected, limit 5); appendix: 5.3 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); gallbladder: 5.1 nTPM (protected, limit 5); bone marrow: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000021574,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,13,9.7,"cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 5); tongue: 9.6 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 7.2 nTPM (protected, limit 5); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); colon: 6.9 nTPM (protected, limit 5); stomach: 6.3 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SPAST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 5); tongue: 9.6 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 5); urinary bladder: 7.2 nTPM (protected, limit 5); appendix: 7.2 nTPM (protected, limit 5); retina: 7.1 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 5); esophagus: 6.9 nTPM (protected, limit 5); gallbladder: 6.4 nTPM (protected, limit 5); stomach: 6.3 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000024526,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,4.9,4.7,"bone marrow: 4.9 nTPM (vital, limit 2); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,DEPDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 4.9 nTPM (vital, limit 2); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000025156,False,excluded,rna_above_tissue_ceiling,True,0,5,partial,46.8,61.7,"tongue: 61.7 nTPM (protected, limit 5); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 5); smooth muscle: 13.5 nTPM (vital, limit 2); lymph node: 12.4 nTPM (protected, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 5); adipose tissue: 9.2 nTPM (protected, limit 5); stomach: 9.1 nTPM (protected, limit 5); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (protected, limit 5); amygdala: 8.5 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); midbrain: 8.4 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 5); rectum: 6.7 nTPM (protected, limit 5); duodenum: 6.7 nTPM (vital, limit 2); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HSF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 61.7 nTPM (protected, limit 5); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 5); smooth muscle: 13.5 nTPM (vital, limit 2); lymph node: 12.4 nTPM (protected, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 5); adipose tissue: 9.2 nTPM (protected, limit 5); stomach: 9.1 nTPM (protected, limit 5); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (protected, limit 5); spinal cord: 8.6 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); midbrain: 8.4 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 5); appendix: 7.6 nTPM (protected, limit 5); gallbladder: 7.3 nTPM (protected, limit 5); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 5); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000027644,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.7,1.7,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus; tonsil,INSRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000035499,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,11,8.8,"bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 5); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DEPDC1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Bruggeman 2018;Bradley 2020,False,False,"gallbladder: 20.3 nTPM (protected, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 5); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000035720,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,8.9,39.8,"lymph node: 39.8 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,STAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 39.8 nTPM (protected, limit 5); appendix: 15 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",appendix / germinal center cells: High (Enhanced); appendix / non-germinal center cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000039139,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,2.8,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),60,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,DNAH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000039600,True,compatible,,True,0,1,partial,0.7,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,SOX30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000041353,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,14.6,43,"stomach: 43 nTPM (protected, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 5); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAB27B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"stomach: 43 nTPM (protected, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 5); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000041515,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,MYO16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000042781,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,18.6,0,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,USH2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000042813,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.5,0.3,"retina: 4.5 nTPM (vital, limit 1)",,48,not_established,not_triggered,,,ZPBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 4.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000043355,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,155.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ZIC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000044459,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,10.2,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CNTLN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000046774,True,compatible,,True,0,2,partial,0,0,,,46,not_established,not_triggered,,,MAGEC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000047617,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,199.6,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000047932,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,21.3,23.2,"thyroid gland: 23.2 nTPM (protected, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 5); heart muscle: 21.3 nTPM (vital, limit 1); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 5); lymph node: 19.5 nTPM (protected, limit 5); colon: 18.1 nTPM (protected, limit 5); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 5); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 5); stomach: 14.5 nTPM (protected, limit 5); kidney: 14 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 5); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GOPC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 23.2 nTPM (protected, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 5); heart muscle: 21.3 nTPM (vital, limit 1); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 5); lymph node: 19.5 nTPM (protected, limit 5); colon: 18.1 nTPM (protected, limit 5); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 5); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); gallbladder: 15.7 nTPM (protected, limit 5); appendix: 15.3 nTPM (protected, limit 5); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (protected, limit 5); urinary bladder: 14.6 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 5); kidney: 14 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 5); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000048545,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,734.2,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,GUCA1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000049167,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,4,"kidney: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ERCC8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"kidney: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000049192,True,compatible,,True,0,2,partial,0.6,0.7,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ADAMTS6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000049768,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,2.3,5.6,"lymph node: 5.6 nTPM (protected, limit 5)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,FOXP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"appendix: 6.8 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5)",appendix / lymphoid tissue: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000050030,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,3,1.8,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,NEXMIF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000051180,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,10.3,10.7,"lymph node: 10.7 nTPM (protected, limit 5); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAD51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"lymph node: 10.7 nTPM (protected, limit 5); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); appendix: 5.4 nTPM (protected, limit 5); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000051341,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.9,2.7,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,POLQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000054796,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPO11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000055955,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,1807.4,5.1,"liver: 1807.4 nTPM (vital, limit 5); pancreas: 47.5 nTPM (vital, limit 5); skeletal muscle: 38.8 nTPM (vital, limit 5); adrenal gland: 17.9 nTPM (vital, limit 5); bone marrow: 9.9 nTPM (vital, limit 5); kidney: 5.2 nTPM (vital, limit 5); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ITIH4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 1807.4 nTPM (vital, limit 5); pancreas: 47.5 nTPM (vital, limit 5); skeletal muscle: 38.8 nTPM (vital, limit 5); adrenal gland: 17.9 nTPM (vital, limit 5); bone marrow: 9.9 nTPM (vital, limit 5); kidney: 5.2 nTPM (vital, limit 5); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000056277,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,2.6,2.2,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF280C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000056291,True,compatible,,True,0,80,unavailable,0.7,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,NPFFR2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000057468,True,compatible,,True,0,80,unavailable,1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,MSH4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000062370,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,5.7,4.3,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ZNF112,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000063127,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15.5,6.7,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC6A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000063438,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,3.3,"cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AHRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000063515,True,compatible,,True,0,0,routine_complete,1,0,,,48,not_established,not_triggered,,,GSC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000064199,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,16.1,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 5); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPA17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 5); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000064703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,8.5,4.4,"skeletal muscle: 8.5 nTPM (vital, limit 5); small intestine: 4.2 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,DDX20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"skeletal muscle: 8.5 nTPM (vital, limit 5); small intestine: 4.2 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000065328,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,9.1,4.7,"bone marrow: 9.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MCM10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000065371,True,compatible,,True,0,3,partial,0.6,0.5,,,46,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ROPN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000065609,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,110.6,2.9,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 5)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SNAP91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 5)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000065883,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,27.3,19.4,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 5); thyroid gland: 18.7 nTPM (protected, limit 5); retina: 18.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 5); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 5); esophagus: 12.5 nTPM (protected, limit 5); rectum: 12.1 nTPM (protected, limit 5); stomach: 11.7 nTPM (protected, limit 5); pancreas: 11.6 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); urinary bladder: 11.4 nTPM (protected, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 5); skeletal muscle: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); duodenum: 10 nTPM (vital, limit 1); adipose tissue: 10 nTPM (protected, limit 5); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,CDK13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 5); thyroid gland: 18.7 nTPM (protected, limit 5); retina: 18.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 5); liver: 14.7 nTPM (vital, limit 1); appendix: 13.3 nTPM (protected, limit 5); tongue: 12.6 nTPM (protected, limit 5); esophagus: 12.5 nTPM (protected, limit 5); rectum: 12.1 nTPM (protected, limit 5); stomach: 11.7 nTPM (protected, limit 5); kidney: 11.6 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); urinary bladder: 11.4 nTPM (protected, limit 5); gallbladder: 11.4 nTPM (protected, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 5); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); duodenum: 10 nTPM (vital, limit 1); adipose tissue: 10 nTPM (protected, limit 5); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000066032,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,91.6,1.9,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 5); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),44,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,CTNNA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 5); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000066185,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.9,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZMYND12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000066279,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10,5.1,"bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ASPM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000066923,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,1.1,0.4,,heart muscle / cardiomyocytes: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,STAG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,heart muscle / cardiomyocytes: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000067646,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,7.9,7.1,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 5); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZFY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 5); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",appendix / glandular cells: Low (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000068489,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.8,10,"bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); small intestine: 4.8 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRR11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 5); appendix: 6.3 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); small intestine: 4.8 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000068796,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,41.4,32.1,"retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 5); urinary bladder: 19.5 nTPM (protected, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 5); colon: 13.3 nTPM (protected, limit 5); bone marrow: 12.6 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 2); thyroid gland: 12.2 nTPM (protected, limit 5); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 5); parathyroid gland: 11.9 nTPM (protected, limit 5); adipose tissue: 11.5 nTPM (protected, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); tongue: 6.5 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 2); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 5); appendix: 22.6 nTPM (protected, limit 5); urinary bladder: 19.5 nTPM (protected, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 5); colon: 13.3 nTPM (protected, limit 5); bone marrow: 12.6 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 2); gallbladder: 12.5 nTPM (protected, limit 5); thyroid gland: 12.2 nTPM (protected, limit 5); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 5); parathyroid gland: 11.9 nTPM (protected, limit 5); adipose tissue: 11.5 nTPM (protected, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); tongue: 6.5 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 2); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000068985,True,compatible,,True,0,5,partial,0,0,,,44,not_established,not_triggered,,,PAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000069188,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1.3,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SDK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000069206,True,compatible,,True,0,0,routine_complete,0.6,0,,,46,not_established,not_triggered,,,ADAM7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000069493,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,19.8,52.7,"lymph node: 52.7 nTPM (protected, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); adipose tissue: 5.9 nTPM (protected, limit 5); urinary bladder: 5.6 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CLEC2D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 52.7 nTPM (protected, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); appendix: 16.4 nTPM (protected, limit 5); lung: 8.3 nTPM (vital, limit 1); adipose tissue: 5.9 nTPM (protected, limit 5); urinary bladder: 5.6 nTPM (protected, limit 5); gallbladder: 5.5 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000070601,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,66.8,1.5,"retina: 66.8 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FRMPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"retina: 66.8 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000070886,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,32.4,0,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,EPHA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000071539,False,excluded,rna_above_tissue_ceiling,True,0,6,partial,5.9,7,"bone marrow: 5.9 nTPM (vital, limit 5); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRIP13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 5.9 nTPM (vital, limit 5); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000071655,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,83.9,44.2,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 5); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (protected, limit 5); esophagus: 41.2 nTPM (protected, limit 5); urinary bladder: 39.7 nTPM (protected, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (protected, limit 5); stomach: 37.8 nTPM (protected, limit 5); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 5); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MBD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 5); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (protected, limit 5); esophagus: 41.2 nTPM (protected, limit 5); urinary bladder: 39.7 nTPM (protected, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (protected, limit 5); stomach: 37.8 nTPM (protected, limit 5); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 5); smooth muscle: 7.1 nTPM (vital, limit 1); appendix: 6.8 nTPM (protected, limit 5); gallbladder: 6.3 nTPM (protected, limit 5); rectum: 6.2 nTPM (protected, limit 5); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000071909,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,5.7,8.5,"parathyroid gland: 8.5 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,MYO3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 8.5 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000072364,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,45.9,35.1,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 5); thyroid gland: 32.2 nTPM (protected, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 5); tongue: 24.6 nTPM (protected, limit 5); stomach: 24.5 nTPM (protected, limit 5); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 5); adipose tissue: 20.7 nTPM (protected, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); colon: 17.8 nTPM (protected, limit 5); rectum: 17 nTPM (protected, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,AFF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 5); thyroid gland: 32.2 nTPM (protected, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 5); gallbladder: 25.1 nTPM (protected, limit 5); tongue: 24.6 nTPM (protected, limit 5); stomach: 24.5 nTPM (protected, limit 5); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 5); adipose tissue: 20.7 nTPM (protected, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); colon: 17.8 nTPM (protected, limit 5); rectum: 17 nTPM (protected, limit 5); appendix: 16.5 nTPM (protected, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000072571,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,20.3,17.7,"bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 5); rectum: 8.5 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); small intestine: 6.3 nTPM (vital, limit 5); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HMMR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 5); appendix: 9.8 nTPM (protected, limit 5); rectum: 8.5 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); small intestine: 6.3 nTPM (vital, limit 5); cerebral cortex: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000073146,False,excluded,rna_above_tissue_ceiling,True,0,0,routine_complete,2.2,1.9,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,MOV10L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000073598,True,compatible,,True,0,1,partial,0,0.1,,,48,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,FNDC8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000075131,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,12.5,9.2,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 5); retina: 7.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 5); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,TIPIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 5); retina: 7.8 nTPM (vital, limit 1); appendix: 6.9 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000075218,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11,9,"bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 5); duodenum: 4 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GTSE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 5); duodenum: 4 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000075388,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FGF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000075702,False,excluded,rna_above_tissue_ceiling,True,0,6,partial,106.5,60.6,"skeletal muscle: 106.5 nTPM (vital, limit 5); tongue: 60.6 nTPM (protected, limit 5); heart muscle: 21.4 nTPM (vital, limit 5); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1)",,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,WDR62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 106.5 nTPM (vital, limit 5); tongue: 60.6 nTPM (protected, limit 5); heart muscle: 21.4 nTPM (vital, limit 5); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000075886,False,excluded,rna_above_tissue_ceiling;family_exclusion,True,0,80,unavailable,83.4,0.4,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,TUBA3D,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;family_exclusion,unchanged
ENSG00000076053,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,39.2,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (protected, limit 5); liver: 17.4 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 5); colon: 12.7 nTPM (protected, limit 5); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); stomach: 11.8 nTPM (protected, limit 5); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 5); smooth muscle: 10.5 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (protected, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBM7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (protected, limit 5); liver: 17.4 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 5); colon: 12.7 nTPM (protected, limit 5); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); stomach: 11.8 nTPM (protected, limit 5); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 5); smooth muscle: 10.5 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (protected, limit 5); gallbladder: 10.1 nTPM (protected, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); appendix: 6.3 nTPM (protected, limit 5); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000077274,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.2,12.6,"stomach: 12.6 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); rectum: 8.3 nTPM (protected, limit 5); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 5); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CAPN6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,False,False,"stomach: 12.6 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); rectum: 8.3 nTPM (protected, limit 5); gallbladder: 8.1 nTPM (protected, limit 5); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); appendix: 7 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000077279,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,6,0.2,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,DCX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000077327,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,96.8,1.7,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; thymus,SPAG6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000077458,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,39,16.7,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 5); adipose tissue: 5.6 nTPM (protected, limit 5); thyroid gland: 5.3 nTPM (protected, limit 5); retina: 5.2 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 2); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,FAM76B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 5); appendix: 12.2 nTPM (protected, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 5); adipose tissue: 5.6 nTPM (protected, limit 5); thyroid gland: 5.3 nTPM (protected, limit 5); retina: 5.2 nTPM (vital, limit 1); gallbladder: 5.1 nTPM (protected, limit 5); adrenal gland: 4.9 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 2); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Approved); lymph node / germinal center cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000077800,True,compatible,,True,0,2,partial,0.2,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus,FKBP6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000077935,True,compatible,,True,0,8,partial,0.3,0.2,,,40,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; thymus; tonsil,SMC1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000078043,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,15.6,11.4,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 5); parathyroid gland: 11.4 nTPM (protected, limit 5); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); bone marrow: 7.3 nTPM (vital, limit 5); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); midbrain: 6 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,PIAS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 5); parathyroid gland: 11.4 nTPM (protected, limit 5); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); bone marrow: 7.3 nTPM (vital, limit 5); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); midbrain: 6 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000078114,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,301,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (protected, limit 5); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 5); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NEBL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,False,False,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (protected, limit 5); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 5); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000078177,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,5.4,3.5,"liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,N4BP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000078487,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.7,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZCWPW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000078795,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,2.2,0.8,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PKD2L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000079101,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,288.9,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,CLUL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000079841,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,63.6,2,"cerebellum: 63.6 nTPM (vital, limit 5); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),48,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,RIMS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 63.6 nTPM (vital, limit 5); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000080007,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,1.2,1.7,,lung / macrophages: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DDX43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,,lung / macrophages: Medium (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000080224,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,3.1,"cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus; tonsil,EPHA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000080572,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,3.9,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),49,not_established,not_triggered,,,DNAAF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000080815,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,81,36,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 5); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (protected, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 5); esophagus: 25.6 nTPM (protected, limit 5); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 5); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 5); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (protected, limit 5); smooth muscle: 20.4 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 5); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 5); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PSEN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 5); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (protected, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 5); esophagus: 25.6 nTPM (protected, limit 5); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 5); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 5); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); gallbladder: 21.6 nTPM (protected, limit 5); adipose tissue: 21.6 nTPM (protected, limit 5); smooth muscle: 20.4 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); appendix: 19 nTPM (protected, limit 5); adrenal gland: 18.4 nTPM (vital, limit 1); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 5); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 5); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000080839,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,14.3,7.6,"bone marrow: 14.3 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 5); lymph node: 7.1 nTPM (protected, limit 5); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 14.3 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 5); lymph node: 7.1 nTPM (protected, limit 5); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000081842,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,3,1.4,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,PCDHA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000081985,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.4,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IL12RB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000083067,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,676.9,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 5); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; thymus,TRPM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 5); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000083290,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,35.9,14.1,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 5); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 5); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 5); adipose tissue: 10.2 nTPM (protected, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 5); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (protected, limit 5); esophagus: 6.1 nTPM (protected, limit 5); pituitary gland: 5.2 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ULK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 5); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 5); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 5); adipose tissue: 10.2 nTPM (protected, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 5); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); gallbladder: 7.2 nTPM (protected, limit 5); stomach: 7.2 nTPM (protected, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (protected, limit 5); esophagus: 6.1 nTPM (protected, limit 5); pituitary gland: 5.2 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000083817,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,4.3,"retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF416,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000083844,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.5,7.1,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); stomach: 7.1 nTPM (protected, limit 5); lymph node: 6.9 nTPM (protected, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 5); adipose tissue: 5.9 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF264,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); stomach: 7.1 nTPM (protected, limit 5); lymph node: 6.9 nTPM (protected, limit 5); appendix: 6.3 nTPM (protected, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 5); adipose tissue: 5.9 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000084693,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,21.7,48.3,"parathyroid gland: 48.3 nTPM (protected, limit 5); thyroid gland: 27.7 nTPM (protected, limit 5); kidney: 21.7 nTPM (vital, limit 1); esophagus: 17.7 nTPM (protected, limit 5); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 5); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 5); rectum: 11.1 nTPM (protected, limit 5); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 5); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AGBL5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"parathyroid gland: 48.3 nTPM (protected, limit 5); thyroid gland: 27.7 nTPM (protected, limit 5); kidney: 21.7 nTPM (vital, limit 1); esophagus: 17.7 nTPM (protected, limit 5); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 5); pancreas: 14.5 nTPM (vital, limit 1); choroid plexus: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 5); smooth muscle: 14.1 nTPM (vital, limit 1); gallbladder: 13.8 nTPM (protected, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 5); rectum: 11.1 nTPM (protected, limit 5); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 5); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); appendix: 7.7 nTPM (protected, limit 5); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000085840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,28.6,6.5,"bone marrow: 28.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 5); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ORC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 28.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 5); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000085999,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,8.6,5.4,"bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); esophagus: 5.2 nTPM (protected, limit 5); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAD54L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); esophagus: 5.2 nTPM (protected, limit 5); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000086200,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,14.2,15.5,"adipose tissue: 15.5 nTPM (protected, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); thyroid gland: 13.6 nTPM (protected, limit 5); parathyroid gland: 13 nTPM (protected, limit 5); urinary bladder: 12.9 nTPM (protected, limit 5); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 5); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 5); choroid plexus: 10 nTPM (vital, limit 1); colon: 8.9 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 5); stomach: 8.2 nTPM (protected, limit 5); hypothalamus: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,IPO11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 15.5 nTPM (protected, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); thyroid gland: 13.6 nTPM (protected, limit 5); parathyroid gland: 13 nTPM (protected, limit 5); urinary bladder: 12.9 nTPM (protected, limit 5); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 5); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); gallbladder: 10.4 nTPM (protected, limit 5); lymph node: 10.1 nTPM (protected, limit 5); choroid plexus: 10 nTPM (vital, limit 1); appendix: 9.4 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); colon: 8.9 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 5); stomach: 8.2 nTPM (protected, limit 5); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000086288,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,12.2,0.5,"bone marrow: 12.2 nTPM (vital, limit 5)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NME8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"bone marrow: 12.2 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000086619,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,177.1,43.3,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 5); thyroid gland: 29.7 nTPM (protected, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 5); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (protected, limit 5); adrenal gland: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ERO1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 5); thyroid gland: 29.7 nTPM (protected, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 5); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); gallbladder: 9.9 nTPM (protected, limit 5); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (protected, limit 5); adrenal gland: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000086717,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.3,0.2,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PPEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,False,False,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000087338,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,15.5,18.5,"parathyroid gland: 18.5 nTPM (protected, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 5); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 5); liver: 10.3 nTPM (vital, limit 1); adipose tissue: 9 nTPM (protected, limit 5); thyroid gland: 8.9 nTPM (protected, limit 5); pancreas: 8.7 nTPM (vital, limit 1); stomach: 8.3 nTPM (protected, limit 5); urinary bladder: 8 nTPM (protected, limit 5); esophagus: 8 nTPM (protected, limit 5); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GMCL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 18.5 nTPM (protected, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 5); lymph node: 11.7 nTPM (protected, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 5); liver: 10.3 nTPM (vital, limit 1); adipose tissue: 9 nTPM (protected, limit 5); thyroid gland: 8.9 nTPM (protected, limit 5); pancreas: 8.7 nTPM (vital, limit 1); stomach: 8.3 nTPM (protected, limit 5); gallbladder: 8.2 nTPM (protected, limit 5); esophagus: 8 nTPM (protected, limit 5); urinary bladder: 8 nTPM (protected, limit 5); appendix: 7.8 nTPM (protected, limit 5); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 5); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000087586,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,15.1,20.4,"lymph node: 20.4 nTPM (protected, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 5); duodenum: 11.6 nTPM (vital, limit 5); colon: 10.4 nTPM (protected, limit 5); small intestine: 9 nTPM (vital, limit 5); skeletal muscle: 8.4 nTPM (vital, limit 5); tongue: 7.9 nTPM (protected, limit 5); esophagus: 7.3 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 5); liver: 4.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,AURKA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lymph node: 20.4 nTPM (protected, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 5); duodenum: 11.6 nTPM (vital, limit 5); colon: 10.4 nTPM (protected, limit 5); appendix: 10.1 nTPM (protected, limit 5); small intestine: 9 nTPM (vital, limit 5); skeletal muscle: 8.4 nTPM (vital, limit 5); tongue: 7.9 nTPM (protected, limit 5); esophagus: 7.3 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 5); liver: 4.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000088325,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,47.4,25.9,"bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 5); rectum: 13.8 nTPM (protected, limit 5); esophagus: 12.8 nTPM (protected, limit 5); colon: 11.3 nTPM (protected, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); liver: 4.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,TPX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 5); rectum: 13.8 nTPM (protected, limit 5); esophagus: 12.8 nTPM (protected, limit 5); appendix: 12.6 nTPM (protected, limit 5); colon: 11.3 nTPM (protected, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); liver: 4.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000088727,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,110.4,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (protected, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 5); spinal cord: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); skeletal muscle: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 5); lung: 8.4 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 5); adipose tissue: 6.3 nTPM (protected, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (protected, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 5); spinal cord: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); skeletal muscle: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 5); lung: 8.4 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 5); adipose tissue: 6.3 nTPM (protected, limit 5); gallbladder: 6.1 nTPM (protected, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000088756,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,8.1,5.2,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ARHGAP28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000088782,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,DEFB127,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000089234,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,33.2,13.4,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 5); lymph node: 10.3 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 5); thyroid gland: 9.7 nTPM (protected, limit 5); liver: 9.7 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 5); esophagus: 9.2 nTPM (protected, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); rectum: 8.9 nTPM (protected, limit 5); urinary bladder: 8.9 nTPM (protected, limit 5); duodenum: 8.9 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BRAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 5); lymph node: 10.3 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 5); liver: 9.7 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (protected, limit 5); heart muscle: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); colon: 9.2 nTPM (protected, limit 5); esophagus: 9.2 nTPM (protected, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); rectum: 8.9 nTPM (protected, limit 5); duodenum: 8.9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 5); adrenal gland: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); appendix: 7.8 nTPM (protected, limit 5); stomach: 7.5 nTPM (protected, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); gallbladder: 7.3 nTPM (protected, limit 5); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000089505,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,1.6,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CMTM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000089685,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,37.4,15.9,"bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); esophagus: 12.4 nTPM (protected, limit 5); rectum: 7.7 nTPM (protected, limit 5); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 5)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,BIRC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); esophagus: 12.4 nTPM (protected, limit 5); appendix: 8.3 nTPM (protected, limit 5); rectum: 7.7 nTPM (protected, limit 5); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 5)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000090402,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,530,30,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 5); colon: 17 nTPM (protected, limit 5)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),68,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,SI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 5); colon: 17 nTPM (protected, limit 5)",appendix / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000090612,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,12.4,12.6,"parathyroid gland: 12.6 nTPM (protected, limit 5); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (protected, limit 5); kidney: 9 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); lymph node: 6 nTPM (protected, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ZNF268,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 12.6 nTPM (protected, limit 5); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (protected, limit 5); kidney: 9 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); lymph node: 6 nTPM (protected, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000090889,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,11.1,5.3,"bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF4A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000091651,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,10.1,7.2,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ORC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000092200,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,179.2,0.5,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RPGRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000092345,True,compatible,,True,0,6,partial,0.2,0.3,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,DAZL,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000092853,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.1,4.8,"bone marrow: 11.1 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLSPN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 11.1 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000093009,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,25.1,11.1,"bone marrow: 25.1 nTPM (vital, limit 1); lymph node: 11.1 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CDC45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 25.1 nTPM (vital, limit 1); lymph node: 11.1 nTPM (protected, limit 5); appendix: 6 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000094804,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,26.9,16,"bone marrow: 26.9 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 5); rectum: 8.4 nTPM (protected, limit 5); colon: 8.1 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); smooth muscle: 3.6 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,CDC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 26.9 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 5); appendix: 13.3 nTPM (protected, limit 5); rectum: 8.4 nTPM (protected, limit 5); colon: 8.1 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); smooth muscle: 3.6 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000094916,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,115.3,24.8,"choroid plexus: 115.3 nTPM (vital, limit 1); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 5); thyroid gland: 23.2 nTPM (protected, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 5); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 5); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 5); rectum: 10.5 nTPM (protected, limit 5); smooth muscle: 10.4 nTPM (vital, limit 5); colon: 10.2 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); small intestine: 8.5 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); liver: 7.8 nTPM (vital, limit 5); tongue: 7.4 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CBX5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 115.3 nTPM (vital, limit 1); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 5); thyroid gland: 23.2 nTPM (protected, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 5); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 5); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 5); appendix: 12.3 nTPM (protected, limit 5); rectum: 10.5 nTPM (protected, limit 5); smooth muscle: 10.4 nTPM (vital, limit 5); colon: 10.2 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); gallbladder: 8.6 nTPM (protected, limit 5); small intestine: 8.5 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); liver: 7.8 nTPM (vital, limit 5); tongue: 7.4 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000095627,True,compatible,,True,0,1,partial,1.6,0.4,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TDRD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023,True,True,,,,unchanged
ENSG00000095777,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,15,0.3,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MYO3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000095794,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,18,partial,131.7,58,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 10); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (protected, limit 10); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 5); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 5); lung: 29.1 nTPM (vital, limit 1); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 5); colon: 23.3 nTPM (protected, limit 5); parathyroid gland: 22.9 nTPM (protected, limit 5); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); thyroid gland: 21.4 nTPM (protected, limit 10); stomach: 19.7 nTPM (protected, limit 5); lymph node: 17 nTPM (protected, limit 10); esophagus: 16.8 nTPM (protected, limit 10); small intestine: 15.1 nTPM (vital, limit 1); pancreas: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); rectum: 13 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,CREM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 10); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (protected, limit 10); appendix: 49.7 nTPM (protected, limit 5); heart muscle: 47.7 nTPM (vital, limit 1); gallbladder: 42.8 nTPM (protected, limit 5); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 5); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 5); lung: 29.1 nTPM (vital, limit 1); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 5); colon: 23.3 nTPM (protected, limit 5); parathyroid gland: 22.9 nTPM (protected, limit 5); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); thyroid gland: 21.4 nTPM (protected, limit 10); stomach: 19.7 nTPM (protected, limit 5); lymph node: 17 nTPM (protected, limit 10); esophagus: 16.8 nTPM (protected, limit 10); small intestine: 15.1 nTPM (vital, limit 1); pancreas: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); rectum: 13 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / germinal center cells: Low (Enhanced); appendix / goblet cells: Medium (Enhanced); appendix / non-germinal center cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000099338,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,0.5,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CATSPERG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000099399,True,compatible,,True,0,3,partial,0.1,0,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,MAGEB2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000099721,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0.3,,,0,not_established,not_triggered,,,AMELY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000099840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,17.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 5); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 5); cerebellum: 6.1 nTPM (vital, limit 5); liver: 5.2 nTPM (vital, limit 5); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IZUMO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 5); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 5); cerebellum: 6.1 nTPM (vital, limit 5); liver: 5.2 nTPM (vital, limit 5); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000099953,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,9.1,3.9,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,MMP11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,False,False,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); gallbladder: 6.6 nTPM (protected, limit 5); small intestine: 5.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000100027,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,25.3,6.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,YPEL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000100121,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,2,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,GGTLC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,False,False,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000100206,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,2.2,2.6,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DMC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000100312,True,compatible,,True,0,3,partial,1.9,2.5,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ACR,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000100478,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,16.2,8.2,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 5); midbrain: 8.2 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); thyroid gland: 7.1 nTPM (protected, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AP4S1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 5); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); thyroid gland: 7.1 nTPM (protected, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); appendix: 5.8 nTPM (protected, limit 5); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000100479,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,18.1,5.2,"bone marrow: 18.1 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 5); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,POLE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 18.1 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 5); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000100485,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,55.4,61.3,"tongue: 61.3 nTPM (protected, limit 5); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 5); thyroid gland: 24.4 nTPM (protected, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (protected, limit 5); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); smooth muscle: 17.3 nTPM (vital, limit 1); colon: 16.8 nTPM (protected, limit 5); rectum: 16.7 nTPM (protected, limit 5); midbrain: 16.7 nTPM (vital, limit 1); esophagus: 15.8 nTPM (protected, limit 5); pancreas: 15.3 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 5); lymph node: 14 nTPM (protected, limit 5); cerebral cortex: 13.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,SOS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 61.3 nTPM (protected, limit 5); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 5); thyroid gland: 24.4 nTPM (protected, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (protected, limit 5); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); smooth muscle: 17.3 nTPM (vital, limit 1); colon: 16.8 nTPM (protected, limit 5); rectum: 16.7 nTPM (protected, limit 5); midbrain: 16.7 nTPM (vital, limit 1); esophagus: 15.8 nTPM (protected, limit 5); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); appendix: 14.9 nTPM (protected, limit 5); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 5); lymph node: 14 nTPM (protected, limit 5); cerebral cortex: 13.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); liver: 12.7 nTPM (vital, limit 2); gallbladder: 12.4 nTPM (protected, limit 5); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000100523,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,16.1,9.7,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 5); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 5); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,DDHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 5); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); appendix: 6 nTPM (protected, limit 5); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); pituitary gland: 5.2 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 5); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000100526,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,42.3,27.7,"bone marrow: 42.3 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 5); rectum: 16.4 nTPM (protected, limit 5); colon: 13.5 nTPM (protected, limit 5); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 5); smooth muscle: 7.2 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CDKN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 42.3 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 5); rectum: 16.4 nTPM (protected, limit 5); colon: 13.5 nTPM (protected, limit 5); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); appendix: 11.8 nTPM (protected, limit 5); esophagus: 9.9 nTPM (protected, limit 5); smooth muscle: 7.2 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000100565,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,LRRC74A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000100583,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,14.5,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SAMD15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000100593,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,2.1,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),46,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,ISM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000100629,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,6.1,4.6,"bone marrow: 6.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CEP128,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 6.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000100890,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,24.1,20.7,"liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 5); rectum: 20.1 nTPM (protected, limit 5); colon: 19.3 nTPM (protected, limit 5); parathyroid gland: 18.6 nTPM (protected, limit 5); esophagus: 18.6 nTPM (protected, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 5); thyroid gland: 15.1 nTPM (protected, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); heart muscle: 13.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (protected, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PRORP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 5); rectum: 20.1 nTPM (protected, limit 5); colon: 19.3 nTPM (protected, limit 5); parathyroid gland: 18.6 nTPM (protected, limit 5); esophagus: 18.6 nTPM (protected, limit 5); tongue: 16.5 nTPM (protected, limit 5); appendix: 16.5 nTPM (protected, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); thyroid gland: 15.1 nTPM (protected, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (protected, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); gallbladder: 10 nTPM (protected, limit 5); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000101003,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,3.8,5,"bone marrow: 3.8 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GINS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 3.8 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000101057,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,90.6,54.2,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); stomach: 5.9 nTPM (protected, limit 5); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MYBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 5); appendix: 23.6 nTPM (protected, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); stomach: 5.9 nTPM (protected, limit 5); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000101074,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,2.3,0.7,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),68,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,R3HDML,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",appendix / goblet cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000101203,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9,0.2,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,COL20A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000101251,True,compatible,,True,0,2,partial,0.1,0,,,46,not_established,not_triggered,,,SEL1L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000101276,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,18.6,11.1,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 5); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 5); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,SLC52A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 5); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 5); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000101353,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,5.6,4.1,"skeletal muscle: 5.6 nTPM (vital, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,MROH8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"skeletal muscle: 5.6 nTPM (vital, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000101435,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CST9L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000101446,True,compatible,existing_nomination_or_manual_review,True,0,8,partial,0,0,,,42,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,SPINT3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000101448,True,compatible,,True,0,1,partial,2.3,0.7,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,EPPIN,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000101746,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.4,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,NOL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000101812,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,H2BW2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000101842,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,2.5,188.6,"stomach: 188.6 nTPM (protected, limit 5); urinary bladder: 8.6 nTPM (protected, limit 5); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,VSIG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"stomach: 188.6 nTPM (protected, limit 5); urinary bladder: 8.6 nTPM (protected, limit 5); gallbladder: 8.1 nTPM (protected, limit 5); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000101883,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,12.6,1.7,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RHOXF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000101890,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,40.9,0,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,GUCY2F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"retina: 40.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000101951,False,excluded,rna_above_tissue_ceiling,True,0,0,routine_complete,23.3,0.3,"smooth muscle: 23.3 nTPM (vital, limit 5); adrenal gland: 5.5 nTPM (vital, limit 5); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen; thymus,PAGE4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"smooth muscle: 23.3 nTPM (vital, limit 5); adrenal gland: 5.5 nTPM (vital, limit 5); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000101977,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,23.2,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MCF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102021,True,compatible,,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,LUZP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000102048,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,16.9,4,"liver: 16.9 nTPM (vital, limit 5); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ASB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"liver: 16.9 nTPM (vital, limit 5); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000102055,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus; tonsil,PPP1R2C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000102076,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,248.2,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,OPN1LW,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 248.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000102098,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,6.2,2.3,"bone marrow: 6.2 nTPM (vital, limit 5); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SCML2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 6.2 nTPM (vital, limit 5); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000102243,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,6.4,21.9,"urinary bladder: 21.9 nTPM (protected, limit 7.5); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,VGLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,False,False,"urinary bladder: 21.9 nTPM (protected, limit 7.5); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102383,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,2.8,1.9,"cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ZDHHC15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000102384,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.5,4.3,"bone marrow: 5.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CENPI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102387,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,3.9,3.8,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; thymus,TAF7L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102543,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,9.2,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (protected, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 5); retina: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,CDADC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (protected, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 5); retina: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000102595,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.3,11.4,"adipose tissue: 11.4 nTPM (protected, limit 5); thyroid gland: 11.1 nTPM (protected, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 5); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,UGGT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 11.4 nTPM (protected, limit 5); thyroid gland: 11.1 nTPM (protected, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 5); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); gallbladder: 5.8 nTPM (protected, limit 5); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102780,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,7.5,5.1,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); smooth muscle: 3.9 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DGKH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); smooth muscle: 3.9 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000102781,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.3,8.4,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adipose tissue: 8.4 nTPM (protected, limit 5); colon: 8.4 nTPM (protected, limit 5); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); tongue: 6.3 nTPM (protected, limit 5); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 5); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KATNAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adipose tissue: 8.4 nTPM (protected, limit 5); colon: 8.4 nTPM (protected, limit 5); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); tongue: 6.3 nTPM (protected, limit 5); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 5); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102924,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,439.8,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (protected, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CBLN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (protected, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); gallbladder: 7.2 nTPM (protected, limit 5); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000102970,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,4.4,8.2,"lymph node: 8.2 nTPM (protected, limit 5); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCL17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 8.2 nTPM (protected, limit 5); appendix: 8 nTPM (protected, limit 5); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000103021,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.3,6.6,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP263,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000103023,True,compatible,,True,0,1,partial,0.1,0,,,47,not_established,not_triggered,,,PRSS54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000103343,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,10,13.6,"parathyroid gland: 13.6 nTPM (protected, limit 5); tongue: 10.2 nTPM (protected, limit 5); colon: 10.1 nTPM (protected, limit 5); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 5); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 5); thyroid gland: 7.3 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 5); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); midbrain: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ZNF174,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 13.6 nTPM (protected, limit 5); tongue: 10.2 nTPM (protected, limit 5); colon: 10.1 nTPM (protected, limit 5); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 5); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); thyroid gland: 7.3 nTPM (protected, limit 5); rectum: 6.9 nTPM (protected, limit 5); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); basal ganglia: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); gallbladder: 5.5 nTPM (protected, limit 5); appendix: 5.3 nTPM (protected, limit 5); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000103546,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,10.1,0.7,"adrenal gland: 10.1 nTPM (vital, limit 5)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,SLC6A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,False,False,"adrenal gland: 10.1 nTPM (vital, limit 5)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000103599,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.8,3.9,"retina: 4.8 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IQCH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.8 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000103642,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,56.5,34.9,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 5); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 5); urinary bladder: 19 nTPM (protected, limit 5); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 5); adipose tissue: 16.7 nTPM (protected, limit 7.5); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 5); esophagus: 14.4 nTPM (protected, limit 5); stomach: 12.4 nTPM (protected, limit 5); choroid plexus: 12 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LACTB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 5); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); appendix: 20.6 nTPM (protected, limit 5); lymph node: 19.3 nTPM (protected, limit 5); duodenum: 19 nTPM (vital, limit 1); urinary bladder: 19 nTPM (protected, limit 5); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 5); adipose tissue: 16.7 nTPM (protected, limit 7.5); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 5); esophagus: 14.4 nTPM (protected, limit 5); gallbladder: 13.8 nTPM (protected, limit 5); stomach: 12.4 nTPM (protected, limit 5); choroid plexus: 12 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000103723,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,44.6,12.3,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AP3B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / enterocytes: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000103995,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,16.2,4.2,"bone marrow: 16.2 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,CEP152,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 16.2 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000104147,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,10.2,5.6,"bone marrow: 10.2 nTPM (vital, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OIP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 10.2 nTPM (vital, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000104218,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13.1,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CSPP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000104432,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 5); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IL7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"lymph node: 8.5 nTPM (protected, limit 5); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000104450,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,10.6,17.7,"rectum: 17.7 nTPM (protected, limit 5); colon: 12.4 nTPM (protected, limit 10); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,SPAG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"rectum: 17.7 nTPM (protected, limit 5); colon: 12.4 nTPM (protected, limit 10); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000104497,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,11.4,16.2,"esophagus: 16.2 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); tongue: 8.9 nTPM (protected, limit 5); stomach: 8.7 nTPM (protected, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 5); thyroid gland: 8.4 nTPM (protected, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 5); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SNX16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"esophagus: 16.2 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); bone marrow: 10.4 nTPM (vital, limit 1); gallbladder: 10.4 nTPM (protected, limit 5); adipose tissue: 9.6 nTPM (protected, limit 5); tongue: 8.9 nTPM (protected, limit 5); stomach: 8.7 nTPM (protected, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 5); thyroid gland: 8.4 nTPM (protected, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 5); lung: 6.5 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); hypothalamus: 5.7 nTPM (vital, limit 1); appendix: 5.7 nTPM (protected, limit 5); small intestine: 5.5 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000104499,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,187.3,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,GML,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,False,False,"adrenal gland: 187.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000104755,True,compatible,,True,0,1,partial,0,0,,,46,not_established,not_triggered,,,ADAM2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000104804,True,compatible,,True,0,80,unavailable,0.7,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,TULP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000104818,True,compatible,,True,0,1,partial,0.6,0.2,,,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CGB2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000104827,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,2.2,0.2,"pituitary gland: 2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,CGB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,False,False,"pituitary gland: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000104835,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,18.2,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 5); thyroid gland: 13.9 nTPM (protected, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); heart muscle: 12 nTPM (vital, limit 1); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 5); tongue: 11.1 nTPM (protected, limit 5); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 5); lymph node: 9.6 nTPM (protected, limit 5); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 5); duodenum: 9 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); spinal cord: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 5); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SARS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); thyroid gland: 13.9 nTPM (protected, limit 5); esophagus: 13.9 nTPM (protected, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); heart muscle: 12 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 5); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 5); lymph node: 9.6 nTPM (protected, limit 5); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 5); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); spinal cord: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); appendix: 7 nTPM (protected, limit 5); lung: 6.4 nTPM (vital, limit 1); gallbladder: 5.7 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000104880,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,30.3,29,"small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 5); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 5); colon: 21.5 nTPM (protected, limit 5); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 5); pituitary gland: 15.4 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); duodenum: 13 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); thyroid gland: 10.5 nTPM (protected, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); adipose tissue: 7.9 nTPM (protected, limit 5); rectum: 7.5 nTPM (protected, limit 5); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ARHGEF18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 5); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 5); colon: 21.5 nTPM (protected, limit 5); pancreas: 20.4 nTPM (vital, limit 1); appendix: 19.4 nTPM (protected, limit 5); esophagus: 19.3 nTPM (protected, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); duodenum: 13 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); thyroid gland: 10.5 nTPM (protected, limit 5); gallbladder: 10.4 nTPM (protected, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); adipose tissue: 7.9 nTPM (protected, limit 5); rectum: 7.5 nTPM (protected, limit 5); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000104901,True,compatible,,True,0,1,partial,0.9,0.7,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,DKKL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000104941,True,compatible,,True,0,2,partial,0,2.7,,,45,not_established,not_triggered,,,RSPH6A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000104951,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,4.7,9,"lymph node: 9 nTPM (protected, limit 5); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,IL4I1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"appendix: 17.6 nTPM (protected, limit 5); lymph node: 9 nTPM (protected, limit 5); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105011,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,11.5,12.2,"lymph node: 12.2 nTPM (protected, limit 5); bone marrow: 11.5 nTPM (vital, limit 5); rectum: 7.5 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ASF1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lymph node: 12.2 nTPM (protected, limit 5); bone marrow: 11.5 nTPM (vital, limit 5); rectum: 7.5 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105085,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,10.9,5.1,"bone marrow: 10.9 nTPM (vital, limit 5); skeletal muscle: 6.7 nTPM (vital, limit 5); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MED26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 10.9 nTPM (vital, limit 5); skeletal muscle: 6.7 nTPM (vital, limit 5); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105143,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,117.1,0.9,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,SLC1A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105146,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,3.4,"choroid plexus: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AURKC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105198,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,not_triggered,,,LGALS13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000105246,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,8.1,19.7,"lymph node: 19.7 nTPM (protected, limit 10); small intestine: 8.1 nTPM (vital, limit 5); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EBI3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"lymph node: 19.7 nTPM (protected, limit 10); appendix: 14.2 nTPM (protected, limit 10); small intestine: 8.1 nTPM (vital, limit 5); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105261,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,OVOL3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,True,True,,,,unchanged
ENSG00000105270,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,215.1,72.7,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 5); urinary bladder: 66 nTPM (protected, limit 5); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 5); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 5); lymph node: 6.8 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLIP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 5); urinary bladder: 66 nTPM (protected, limit 5); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 5); gallbladder: 22.6 nTPM (protected, limit 5); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); appendix: 9.5 nTPM (protected, limit 5); rectum: 8.3 nTPM (protected, limit 5); lymph node: 6.8 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105428,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,ZNRF4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000105467,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,6.1,3.8,"cerebellum: 6.1 nTPM (vital, limit 5)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),44,not_established,not_triggered,,,SYNGR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"cerebellum: 6.1 nTPM (vital, limit 5)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105479,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,28.3,0.6,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; thymus,ODAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105492,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,4.3,3.7,"small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SIGLEC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105549,True,compatible,,True,0,80,unavailable,0.8,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,THEG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000105647,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,42.4,25.3,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); esophagus: 25.3 nTPM (protected, limit 5); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 5); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 5); stomach: 14.7 nTPM (protected, limit 5); colon: 13 nTPM (protected, limit 5); hypothalamus: 13 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (protected, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); kidney: 9.3 nTPM (vital, limit 1); rectum: 9.3 nTPM (protected, limit 5); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PIK3R2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); esophagus: 25.3 nTPM (protected, limit 5); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 5); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 5); stomach: 14.7 nTPM (protected, limit 5); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 5); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); gallbladder: 11.8 nTPM (protected, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (protected, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); kidney: 9.3 nTPM (vital, limit 1); rectum: 9.3 nTPM (protected, limit 5); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); appendix: 6.7 nTPM (protected, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000105672,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,1.8,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ETV2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105679,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,5,11.1,"thyroid gland: 11.1 nTPM (protected, limit 10); retina: 3.4 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,GAPDHS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"thyroid gland: 11.1 nTPM (protected, limit 10); retina: 3.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105737,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,32.7,15.9,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 5); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 5); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 5); heart muscle: 4.8 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GRIK5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 5); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 5); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 5); heart muscle: 4.8 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105750,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,7.9,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF85,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000105793,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,18.1,10.6,"liver: 18.1 nTPM (vital, limit 2); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 5); stomach: 10.4 nTPM (protected, limit 5); tongue: 9.7 nTPM (protected, limit 5); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (protected, limit 5); rectum: 9.3 nTPM (protected, limit 5); urinary bladder: 9.2 nTPM (protected, limit 5); colon: 8.5 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (protected, limit 5); esophagus: 8 nTPM (protected, limit 5); parathyroid gland: 7.8 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GTPBP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 18.1 nTPM (vital, limit 2); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 5); stomach: 10.4 nTPM (protected, limit 5); heart muscle: 9.7 nTPM (vital, limit 2); tongue: 9.7 nTPM (protected, limit 5); thyroid gland: 9.5 nTPM (protected, limit 5); rectum: 9.3 nTPM (protected, limit 5); urinary bladder: 9.2 nTPM (protected, limit 5); appendix: 8.7 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 5); adipose tissue: 8.2 nTPM (protected, limit 5); esophagus: 8 nTPM (protected, limit 5); parathyroid gland: 7.8 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); bone marrow: 6.4 nTPM (vital, limit 2); lung: 5.6 nTPM (vital, limit 1); gallbladder: 5.4 nTPM (protected, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000105825,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,74.1,49.6,"pancreas: 74.1 nTPM (vital, limit 5); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (protected, limit 10); adrenal gland: 27.4 nTPM (vital, limit 5); urinary bladder: 25.6 nTPM (protected, limit 10); liver: 20.6 nTPM (vital, limit 5); kidney: 19.8 nTPM (vital, limit 5); lung: 10.9 nTPM (vital, limit 5); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 5); heart muscle: 7.5 nTPM (vital, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TFPI2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"pancreas: 74.1 nTPM (vital, limit 5); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (protected, limit 10); appendix: 35.5 nTPM (protected, limit 10); adrenal gland: 27.4 nTPM (vital, limit 5); urinary bladder: 25.6 nTPM (protected, limit 10); liver: 20.6 nTPM (vital, limit 5); kidney: 19.8 nTPM (vital, limit 5); gallbladder: 15.1 nTPM (protected, limit 10); lung: 10.9 nTPM (vital, limit 5); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 5); heart muscle: 7.5 nTPM (vital, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105851,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,43.1,18.5,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 5); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PIK3CG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 5); appendix: 11.1 nTPM (protected, limit 5); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105877,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,7,68.9,"parathyroid gland: 68.9 nTPM (protected, limit 5); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; thymus,DNAH11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 68.9 nTPM (protected, limit 5); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000105879,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,34.7,18.1,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 5); lymph node: 14.7 nTPM (protected, limit 5); retina: 13.9 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (protected, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); liver: 10.3 nTPM (vital, limit 1); adipose tissue: 10.3 nTPM (protected, limit 5); esophagus: 10.1 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 5); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CBLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 5); lymph node: 14.7 nTPM (protected, limit 5); retina: 13.9 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (protected, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); appendix: 11.7 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); adipose tissue: 10.3 nTPM (protected, limit 5); liver: 10.3 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 5); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); gallbladder: 7.8 nTPM (protected, limit 5); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000105889,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.5,1.6,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,STEAP1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000105948,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,12,partial,11.1,7.9,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IFT56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000105982,False,excluded,rna_above_tissue_ceiling,True,0,9,partial,3.4,2.9,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RNF32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000106013,True,compatible,,True,0,80,unavailable,0.7,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANKRD7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000106125,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,11.8,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (protected, limit 5); adipose tissue: 6.4 nTPM (protected, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,MINDY4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (protected, limit 5); adipose tissue: 6.4 nTPM (protected, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); gallbladder: 5.4 nTPM (protected, limit 5); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000106304,True,compatible,,True,0,1,partial,0.4,0,,,46,not_established,not_triggered,,,SPAM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000106328,True,compatible,,True,0,1,partial,0.5,0.1,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,FSCN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000106336,True,compatible,,True,0,3,partial,1,1.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FBXO24,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000106410,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,NOBOX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000106588,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,308.9,115.4,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 5); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 5); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 5); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 5); adipose tissue: 97.5 nTPM (protected, limit 5); small intestine: 93.9 nTPM (vital, limit 1); urinary bladder: 88.9 nTPM (protected, limit 5); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 5); rectum: 83.7 nTPM (protected, limit 5); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 5); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (protected, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PSMA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); bone marrow: 118.5 nTPM (vital, limit 1); heart muscle: 115.4 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 5); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 5); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 5); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 5); adipose tissue: 97.5 nTPM (protected, limit 5); small intestine: 93.9 nTPM (vital, limit 1); urinary bladder: 88.9 nTPM (protected, limit 5); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 5); appendix: 86.3 nTPM (protected, limit 5); rectum: 83.7 nTPM (protected, limit 5); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 5); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (protected, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); gallbladder: 47.7 nTPM (protected, limit 5); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000106638,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15.5,6,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000106648,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,1.4,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),45,not_established,not_triggered,,,GALNTL5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000106829,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,68.1,17.6,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); urinary bladder: 17.6 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); esophagus: 15.4 nTPM (protected, limit 5); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 5); rectum: 10.1 nTPM (protected, limit 5); thyroid gland: 9.9 nTPM (protected, limit 5); colon: 9.6 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TLE4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); urinary bladder: 17.6 nTPM (protected, limit 5); appendix: 15.8 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); esophagus: 15.4 nTPM (protected, limit 5); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); gallbladder: 15 nTPM (protected, limit 5); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 5); rectum: 10.1 nTPM (protected, limit 5); thyroid gland: 9.9 nTPM (protected, limit 5); colon: 9.6 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000107036,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,17,16.9,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 5); tongue: 15.1 nTPM (protected, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); smooth muscle: 12.8 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (protected, limit 7.5); esophagus: 11 nTPM (protected, limit 5); thyroid gland: 10.9 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 5); small intestine: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 5); colon: 8.1 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); retina: 7.2 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RIC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 5); tongue: 15.1 nTPM (protected, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); smooth muscle: 12.8 nTPM (vital, limit 1); appendix: 12.3 nTPM (protected, limit 5); adipose tissue: 11.4 nTPM (protected, limit 7.5); esophagus: 11 nTPM (protected, limit 5); gallbladder: 11 nTPM (protected, limit 5); thyroid gland: 10.9 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 5); small intestine: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 5); colon: 8.1 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000107077,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,38.3,18.7,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 5); parathyroid gland: 17.2 nTPM (protected, limit 5); choroid plexus: 16.3 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 5); stomach: 14.7 nTPM (protected, limit 5); small intestine: 14 nTPM (vital, limit 1); colon: 13.3 nTPM (protected, limit 5); thyroid gland: 13 nTPM (protected, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 5); esophagus: 9.9 nTPM (protected, limit 5); adipose tissue: 9.7 nTPM (protected, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KDM4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 5); parathyroid gland: 17.2 nTPM (protected, limit 5); choroid plexus: 16.3 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 5); stomach: 14.7 nTPM (protected, limit 5); small intestine: 14 nTPM (vital, limit 1); colon: 13.3 nTPM (protected, limit 5); thyroid gland: 13 nTPM (protected, limit 5); duodenum: 12.7 nTPM (vital, limit 1); appendix: 12.5 nTPM (protected, limit 5); pituitary gland: 11.5 nTPM (vital, limit 1); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 5); esophagus: 9.9 nTPM (protected, limit 5); adipose tissue: 9.7 nTPM (protected, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); gallbladder: 9.4 nTPM (protected, limit 5); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000107105,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,24.2,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ELAVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000107518,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,19.4,2.3,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ATRNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000107614,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,5.6,3.6,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TRDMT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000108106,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,114.3,36,"bone marrow: 114.3 nTPM (vital, limit 2); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 5); lymph node: 34.8 nTPM (protected, limit 5); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 5); stomach: 17.1 nTPM (protected, limit 5); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (protected, limit 5); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 5); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); thyroid gland: 10 nTPM (protected, limit 5); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 5); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 5); tongue: 5.4 nTPM (protected, limit 5)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,UBE2S,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 114.3 nTPM (vital, limit 2); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 5); lymph node: 34.8 nTPM (protected, limit 5); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); heart muscle: 24 nTPM (vital, limit 2); appendix: 21.2 nTPM (protected, limit 5); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 5); stomach: 17.1 nTPM (protected, limit 5); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (protected, limit 5); urinary bladder: 15.7 nTPM (protected, limit 5); lung: 15.7 nTPM (vital, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); gallbladder: 12.7 nTPM (protected, limit 5); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); thyroid gland: 10 nTPM (protected, limit 5); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 5); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 5); tongue: 5.4 nTPM (protected, limit 5)",appendix / lymphoid tissue: Medium (Approved); colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000108666,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,25.4,26.9,"parathyroid gland: 26.9 nTPM (protected, limit 5); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 5); thyroid gland: 13.6 nTPM (protected, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); lymph node: 12.6 nTPM (protected, limit 5); stomach: 12.6 nTPM (protected, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 5); colon: 11.3 nTPM (protected, limit 5); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 5); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); adipose tissue: 7.8 nTPM (protected, limit 5); bone marrow: 7.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C17orf75,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 26.9 nTPM (protected, limit 5); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); choroid plexus: 18.7 nTPM (vital, limit 1); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 5); thyroid gland: 13.6 nTPM (protected, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); lymph node: 12.6 nTPM (protected, limit 5); rectum: 12.2 nTPM (protected, limit 5); colon: 11.3 nTPM (protected, limit 5); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); appendix: 10.1 nTPM (protected, limit 5); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 5); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); adipose tissue: 7.8 nTPM (protected, limit 5); bone marrow: 7.5 nTPM (vital, limit 1); gallbladder: 6.7 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000108786,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.3,5.9,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HSD17B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000109171,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,69.6,94.8,"tongue: 94.8 nTPM (protected, limit 5); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 5); smooth muscle: 34.2 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 5); colon: 26.4 nTPM (protected, limit 5); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 5); adipose tissue: 24.2 nTPM (protected, limit 5); rectum: 24 nTPM (protected, limit 5); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (protected, limit 5); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 5); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 5); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,SLAIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 94.8 nTPM (protected, limit 5); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 5); smooth muscle: 34.2 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 5); colon: 26.4 nTPM (protected, limit 5); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 5); adipose tissue: 24.2 nTPM (protected, limit 5); rectum: 24 nTPM (protected, limit 5); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (protected, limit 5); kidney: 18.5 nTPM (vital, limit 2); gallbladder: 18.1 nTPM (protected, limit 5); stomach: 18.1 nTPM (protected, limit 5); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 5); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); appendix: 14.9 nTPM (protected, limit 5); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000109184,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,28,16.4,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 5); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 5); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (protected, limit 5); hippocampal formation: 13.2 nTPM (vital, limit 1); basal ganglia: 13.2 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (protected, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 5); esophagus: 10 nTPM (protected, limit 5); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 5); lymph node: 7.3 nTPM (protected, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DCUN1D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 5); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 5); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (protected, limit 5); hippocampal formation: 13.2 nTPM (vital, limit 1); basal ganglia: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); thyroid gland: 12.8 nTPM (protected, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); gallbladder: 11 nTPM (protected, limit 5); tongue: 10.9 nTPM (protected, limit 5); esophagus: 10 nTPM (protected, limit 5); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 5); lymph node: 7.3 nTPM (protected, limit 5); appendix: 7.1 nTPM (protected, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000109265,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,18.8,8.8,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 5); rectum: 7.5 nTPM (protected, limit 5); parathyroid gland: 5.8 nTPM (protected, limit 5); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CRACD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); gallbladder: 11.1 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); rectum: 7.5 nTPM (protected, limit 5); parathyroid gland: 5.8 nTPM (protected, limit 5); cerebral cortex: 5.7 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000109618,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,25.3,5.1,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SEPSECS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000109674,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.5,3.5,"bone marrow: 6.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NEIL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 6.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000109684,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,6.1,2.6,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CLNK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000109771,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,28,3.5,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,LRP2BP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000109832,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,22,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 5); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,DDX25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 5); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000109851,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000109881,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21.7,9.8,"choroid plexus: 21.7 nTPM (vital, limit 1); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 5); stomach: 9 nTPM (protected, limit 5); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 5); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); retina: 6 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); pituitary gland: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 21.7 nTPM (vital, limit 1); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 5); stomach: 9 nTPM (protected, limit 5); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 5); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); retina: 6 nTPM (vital, limit 1); appendix: 5.5 nTPM (protected, limit 5); thyroid gland: 5.4 nTPM (protected, limit 5); pituitary gland: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000109927,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,1.7,0.8,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,TECTA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000110090,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,69.3,65.2,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 5); rectum: 43.2 nTPM (protected, limit 5); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 5); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); parathyroid gland: 26.7 nTPM (protected, limit 5); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (protected, limit 7.5); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 5); choroid plexus: 18.9 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 5); lymph node: 15.5 nTPM (protected, limit 5); thyroid gland: 15 nTPM (protected, limit 5); pituitary gland: 14 nTPM (vital, limit 1); midbrain: 13.7 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CPT1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 5); rectum: 43.2 nTPM (protected, limit 5); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 5); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); gallbladder: 26.8 nTPM (protected, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 5); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (protected, limit 7.5); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); appendix: 21.7 nTPM (protected, limit 5); esophagus: 21.3 nTPM (protected, limit 5); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 5); basal ganglia: 18.1 nTPM (vital, limit 1); lymph node: 15.5 nTPM (protected, limit 5); thyroid gland: 15 nTPM (protected, limit 5); pituitary gland: 14 nTPM (vital, limit 1); midbrain: 13.7 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000110422,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,66.5,82,"tongue: 82 nTPM (protected, limit 5); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (protected, limit 5); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 5); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (protected, limit 5); urinary bladder: 31.2 nTPM (protected, limit 5); esophagus: 29.8 nTPM (protected, limit 5); colon: 29.7 nTPM (protected, limit 5); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 5); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 5); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HIPK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 82 nTPM (protected, limit 5); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (protected, limit 5); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 5); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (protected, limit 5); urinary bladder: 31.2 nTPM (protected, limit 5); esophagus: 29.8 nTPM (protected, limit 5); colon: 29.7 nTPM (protected, limit 5); gallbladder: 29.6 nTPM (protected, limit 5); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); appendix: 24.7 nTPM (protected, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 5); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 5); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000110693,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,15,partial,26.5,5.7,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 5); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,SOX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 5); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); appendix / endocrine cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000110975,True,compatible,,True,0,80,unavailable,0.8,0.7,,,0,not_established,required,in_situ_inflammation_review,appendix,SYT10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000111052,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,27.6,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); thyroid gland / glandular cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,LIN7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000111247,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.7,8.7,"bone marrow: 16.7 nTPM (vital, limit 1); lymph node: 8.7 nTPM (protected, limit 5); rectum: 6.3 nTPM (protected, limit 5); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RAD51AP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 16.7 nTPM (vital, limit 1); lymph node: 8.7 nTPM (protected, limit 5); rectum: 6.3 nTPM (protected, limit 5); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000111254,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,4.1,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AKAP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,False,False,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000111305,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,29.5,0.3,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GSG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000111644,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,10.5,13.4,"thyroid gland: 13.4 nTPM (protected, limit 10); bone marrow: 10.5 nTPM (vital, limit 5); duodenum: 8.2 nTPM (vital, limit 5); small intestine: 7.9 nTPM (vital, limit 5); retina: 1.7 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACRBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"thyroid gland: 13.4 nTPM (protected, limit 10); bone marrow: 10.5 nTPM (vital, limit 5); duodenum: 8.2 nTPM (vital, limit 5); small intestine: 7.9 nTPM (vital, limit 5); retina: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000111837,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,115.3,4.5,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,MAK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000111911,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,108.6,81.2,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 5); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 5); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); stomach: 24.2 nTPM (protected, limit 5); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 22.7 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (protected, limit 5); esophagus: 21.5 nTPM (protected, limit 5); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 5); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 5); adipose tissue: 17.4 nTPM (protected, limit 5); rectum: 17 nTPM (protected, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 5); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,HINT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 5); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 5); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); stomach: 24.2 nTPM (protected, limit 5); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (protected, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 5); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 5); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 5); adipose tissue: 17.4 nTPM (protected, limit 5); rectum: 17 nTPM (protected, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); gallbladder: 15.6 nTPM (protected, limit 5); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); appendix: 12.2 nTPM (protected, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 5); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000112029,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,43.5,14.5,"bone marrow: 43.5 nTPM (vital, limit 1); lymph node: 14.5 nTPM (protected, limit 5); smooth muscle: 4.8 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FBXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 43.5 nTPM (vital, limit 1); lymph node: 14.5 nTPM (protected, limit 5); appendix: 7.1 nTPM (protected, limit 5); smooth muscle: 4.8 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000112038,True,compatible,,True,0,3,partial,2.1,1,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OPRM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000112053,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,4.9,0.2,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,SLC26A8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000112116,True,compatible,,True,0,80,unavailable,0,0.9,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; thymus; tonsil,IL17F,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000112182,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,7.2,17.1,"lymph node: 17.1 nTPM (protected, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,BACH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 17.1 nTPM (protected, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000112238,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,PRDM13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000112246,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.5,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SIM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000112273,True,compatible,,True,0,2,partial,0.4,0,,,46,not_established,not_triggered,,,HDGFL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000112282,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21.7,17.7,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 5); lymph node: 14.5 nTPM (protected, limit 5); thyroid gland: 14 nTPM (protected, limit 5); rectum: 12.1 nTPM (protected, limit 5); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 5); duodenum: 11.1 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 5); tongue: 9.7 nTPM (protected, limit 5); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 5); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MED23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 5); lymph node: 14.5 nTPM (protected, limit 5); thyroid gland: 14 nTPM (protected, limit 5); rectum: 12.1 nTPM (protected, limit 5); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 5); appendix: 11.2 nTPM (protected, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 5); tongue: 9.7 nTPM (protected, limit 5); lung: 9.6 nTPM (vital, limit 1); gallbladder: 8.6 nTPM (protected, limit 5); esophagus: 8.2 nTPM (protected, limit 5); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000112541,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,22.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PDE10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000112619,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,621.9,4.1,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 5); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRPH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 5); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000112742,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,25,7.9,"bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); rectum: 5.7 nTPM (protected, limit 5); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TTK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); rectum: 5.7 nTPM (protected, limit 5); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000112761,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,0.3,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,CCN6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000112796,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,29.7,49.5,"thyroid gland: 49.5 nTPM (protected, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 5); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 5); pancreas: 9.4 nTPM (vital, limit 5); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); heart muscle: 4.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENPP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 49.5 nTPM (protected, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 5); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 5); pancreas: 9.4 nTPM (vital, limit 5); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); gallbladder: 6.8 nTPM (protected, limit 5); stomach: 6.5 nTPM (protected, limit 5); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); heart muscle: 4.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000112852,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,4.4,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000113205,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,PCDHB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000113209,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,4.6,2.6,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PCDHB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000113211,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,1.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000113396,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,23.6,4.1,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,SLC27A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000113525,True,compatible,,True,0,6,partial,0.8,0.4,,,42,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,IL5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,True,True,,,,unchanged
ENSG00000113966,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,36.8,12.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ARL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 5); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000114098,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,59.8,33.4,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 5); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 5); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 5); thyroid gland: 20.7 nTPM (protected, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 5); esophagus: 20.3 nTPM (protected, limit 5); adipose tissue: 20.1 nTPM (protected, limit 5); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 5); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 5); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); stomach: 15 nTPM (protected, limit 5); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ARMC8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 5); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 5); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 5); thyroid gland: 20.7 nTPM (protected, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 5); esophagus: 20.3 nTPM (protected, limit 5); adipose tissue: 20.1 nTPM (protected, limit 5); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 5); appendix: 17.5 nTPM (protected, limit 5); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 5); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); stomach: 15 nTPM (protected, limit 5); gallbladder: 14.7 nTPM (protected, limit 5); midbrain: 14.5 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000114349,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,1086,0.2,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,GNAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000114487,True,compatible,,True,0,1,partial,0.3,0.1,,,47,not_established,not_triggered,,,MORC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000114547,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,2.9,0.8,"basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ROPN1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000114656,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.5,1.6,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP92,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000114739,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,6.3,3.2,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ACVR2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000114757,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,48.8,29.2,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 5); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,PEX5L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 5); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000114982,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,32.7,20.3,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 5); urinary bladder: 12.6 nTPM (protected, limit 5); thyroid gland: 12.5 nTPM (protected, limit 5); small intestine: 11.6 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 5); adipose tissue: 11.4 nTPM (protected, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 5); pancreas: 9.5 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 5); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 5); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KANSL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 5); urinary bladder: 12.6 nTPM (protected, limit 5); thyroid gland: 12.5 nTPM (protected, limit 5); small intestine: 11.6 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 5); adipose tissue: 11.4 nTPM (protected, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 5); esophagus: 8.6 nTPM (protected, limit 5); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); appendix: 8.3 nTPM (protected, limit 5); lymph node: 8 nTPM (protected, limit 5); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); gallbladder: 6.6 nTPM (protected, limit 5); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000115008,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,25,"urinary bladder: 25 nTPM (protected, limit 5); esophagus: 12.9 nTPM (protected, limit 5); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IL1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"urinary bladder: 25 nTPM (protected, limit 5); esophagus: 12.9 nTPM (protected, limit 5); lung: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000115159,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,23.8,19.8,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 5); esophagus: 19.7 nTPM (protected, limit 5); colon: 18 nTPM (protected, limit 5); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 5); stomach: 17 nTPM (protected, limit 5); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 5); tongue: 13.7 nTPM (protected, limit 5); bone marrow: 13.2 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); adipose tissue: 7.9 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GPD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 5); esophagus: 19.7 nTPM (protected, limit 5); colon: 18 nTPM (protected, limit 5); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 5); stomach: 17 nTPM (protected, limit 5); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 5); tongue: 13.7 nTPM (protected, limit 5); bone marrow: 13.2 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); gallbladder: 8.6 nTPM (protected, limit 5); adipose tissue: 7.9 nTPM (protected, limit 5); appendix: 7.9 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000115163,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,11,partial,4,7.2,"lymph node: 7.2 nTPM (protected, limit 5); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CENPA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 7.2 nTPM (protected, limit 5); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000115194,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,28.8,0.5,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 5)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,SLC30A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 5)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000115239,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,22.2,11.2,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); parathyroid gland: 10 nTPM (protected, limit 5); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); kidney: 8.6 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 5); adipose tissue: 8.1 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 7.5 nTPM (protected, limit 5); colon: 7.3 nTPM (protected, limit 5); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 5); stomach: 6.9 nTPM (protected, limit 5); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ASB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); parathyroid gland: 10 nTPM (protected, limit 5); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); kidney: 8.6 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 5); adipose tissue: 8.1 nTPM (protected, limit 5); appendix: 8 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 7.5 nTPM (protected, limit 5); gallbladder: 7.4 nTPM (protected, limit 5); colon: 7.3 nTPM (protected, limit 5); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 5); stomach: 6.9 nTPM (protected, limit 5); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000115252,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,40.2,41.6,"thyroid gland: 41.6 nTPM (protected, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (protected, limit 5); urinary bladder: 9.4 nTPM (protected, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PDE1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 41.6 nTPM (protected, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); gallbladder: 20.8 nTPM (protected, limit 5); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (protected, limit 5); urinary bladder: 9.4 nTPM (protected, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000115257,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.9,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCSK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000115274,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,40.9,38.1,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (protected, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 5); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 5); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 5); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (protected, limit 5); lung: 25.1 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 5); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 5); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 5); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 5); tongue: 8.8 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,INO80B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (protected, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 5); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 5); adrenal gland: 29.5 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 5); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (protected, limit 5); lung: 25.1 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); small intestine: 23.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 5); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 5); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 5); retina: 18.1 nTPM (vital, limit 1); appendix: 17.5 nTPM (protected, limit 5); choroid plexus: 15.5 nTPM (vital, limit 1); gallbladder: 14.6 nTPM (protected, limit 5); smooth muscle: 14.2 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 5); tongue: 8.8 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000115970,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,16.9,14,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 5); thyroid gland: 13.1 nTPM (protected, limit 5); parathyroid gland: 12 nTPM (protected, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (protected, limit 5); urinary bladder: 10.2 nTPM (protected, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 5); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); bone marrow: 8.7 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); tongue: 5.9 nTPM (protected, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,THADA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 5); thyroid gland: 13.1 nTPM (protected, limit 5); parathyroid gland: 12 nTPM (protected, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (protected, limit 5); urinary bladder: 10.2 nTPM (protected, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 5); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); bone marrow: 8.7 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); appendix: 7.3 nTPM (protected, limit 5); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); gallbladder: 5.9 nTPM (protected, limit 5); tongue: 5.9 nTPM (protected, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000116183,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,6.1,1.5,"kidney: 6.1 nTPM (vital, limit 5); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,46,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,PAPPA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,False,False,"kidney: 6.1 nTPM (vital, limit 5); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000116191,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,52.1,45.3,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 10); liver: 28.8 nTPM (vital, limit 5); esophagus: 17.3 nTPM (protected, limit 5); small intestine: 15.9 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 10); colon: 13.4 nTPM (protected, limit 5); urinary bladder: 12.3 nTPM (protected, limit 10); rectum: 12 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 5); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 5); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 5); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,RALGPS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 10); liver: 28.8 nTPM (vital, limit 5); appendix: 21.4 nTPM (protected, limit 5); esophagus: 17.3 nTPM (protected, limit 5); small intestine: 15.9 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 10); colon: 13.4 nTPM (protected, limit 5); urinary bladder: 12.3 nTPM (protected, limit 10); rectum: 12 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 5); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 5); gallbladder: 8.5 nTPM (protected, limit 5); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 5); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000116721,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000116726,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,1,unreliable,0.1,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,PRAMEF12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,appendix / glandular cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000116793,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,28.2,11.1,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); hypothalamus: 8.6 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 5); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); lymph node: 5.5 nTPM (protected, limit 5); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PHTF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); hypothalamus: 8.6 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); gallbladder: 6.7 nTPM (protected, limit 5); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); smooth muscle: 6.4 nTPM (vital, limit 1); appendix: 6.3 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); lymph node: 5.5 nTPM (protected, limit 5); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000116977,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,53,33.9,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); parathyroid gland: 33.9 nTPM (protected, limit 5); urinary bladder: 31.6 nTPM (protected, limit 5); adipose tissue: 27.6 nTPM (protected, limit 5); lung: 26.2 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 5); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 5); rectum: 19.3 nTPM (protected, limit 5); colon: 19.3 nTPM (protected, limit 5); stomach: 18.4 nTPM (protected, limit 5); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LGALS8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); parathyroid gland: 33.9 nTPM (protected, limit 5); urinary bladder: 31.6 nTPM (protected, limit 5); adipose tissue: 27.6 nTPM (protected, limit 5); lung: 26.2 nTPM (vital, limit 1); appendix: 25.8 nTPM (protected, limit 5); gallbladder: 24 nTPM (protected, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 5); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 5); rectum: 19.3 nTPM (protected, limit 5); colon: 19.3 nTPM (protected, limit 5); stomach: 18.4 nTPM (protected, limit 5); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000117148,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,not_triggered,,,ACTL8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000117155,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,10,partial,115.1,8.9,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 5); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); rectum: 7.6 nTPM (protected, limit 5); stomach: 6.9 nTPM (protected, limit 5); pancreas: 6.9 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); lymph node: 6.2 nTPM (protected, limit 5); urinary bladder: 5.5 nTPM (protected, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SSX2IP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 5); gallbladder: 8.4 nTPM (protected, limit 5); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); rectum: 7.6 nTPM (protected, limit 5); stomach: 6.9 nTPM (protected, limit 5); pancreas: 6.9 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); lymph node: 6.2 nTPM (protected, limit 5); appendix: 5.6 nTPM (protected, limit 5); urinary bladder: 5.5 nTPM (protected, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000117400,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,MPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000117461,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,45.2,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (protected, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 5); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 5); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (protected, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 5); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); amygdala: 10.5 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 5); esophagus: 6.9 nTPM (protected, limit 5); lymph node: 6.1 nTPM (protected, limit 5); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PIK3R3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (protected, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 5); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 5); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (protected, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 5); midbrain: 11.6 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); amygdala: 10.5 nTPM (vital, limit 1); gallbladder: 10.4 nTPM (protected, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 5); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 5); appendix: 7.1 nTPM (protected, limit 5); esophagus: 6.9 nTPM (protected, limit 5); lymph node: 6.1 nTPM (protected, limit 5); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000117475,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,25.1,31.3,"esophagus: 31.3 nTPM (protected, limit 5); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (protected, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 5); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 5); liver: 14.5 nTPM (vital, limit 1); adipose tissue: 14.4 nTPM (protected, limit 7.5); colon: 13.4 nTPM (protected, limit 5); adrenal gland: 12.7 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 5); lung: 12.5 nTPM (vital, limit 1); small intestine: 12.3 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 5); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 5); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BLZF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"esophagus: 31.3 nTPM (protected, limit 5); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (protected, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 5); gallbladder: 15.8 nTPM (protected, limit 5); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 5); liver: 14.5 nTPM (vital, limit 1); adipose tissue: 14.4 nTPM (protected, limit 7.5); colon: 13.4 nTPM (protected, limit 5); stomach: 12.7 nTPM (protected, limit 5); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); small intestine: 12.3 nTPM (vital, limit 1); appendix: 12.1 nTPM (protected, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 5); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 5); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000117477,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,38.7,11.2,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); parathyroid gland: 11.2 nTPM (protected, limit 10); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 5); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 5); kidney: 5.6 nTPM (vital, limit 5); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,CCDC181,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); parathyroid gland: 11.2 nTPM (protected, limit 10); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 5); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 5); kidney: 5.6 nTPM (vital, limit 5); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000117569,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,20.3,32.3,"colon: 32.3 nTPM (protected, limit 5); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 5); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (protected, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 5); thyroid gland: 11.6 nTPM (protected, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); lung: 8.4 nTPM (vital, limit 1); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 5); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); lymph node: 5.8 nTPM (protected, limit 5); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,PTBP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"colon: 32.3 nTPM (protected, limit 5); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 5); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (protected, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 5); thyroid gland: 11.6 nTPM (protected, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); lung: 8.4 nTPM (vital, limit 1); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 5); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); lymph node: 5.8 nTPM (protected, limit 5); appendix: 5.8 nTPM (protected, limit 5); gallbladder: 5.6 nTPM (protected, limit 5); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000117586,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,1.9,2.2,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TNFSF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000117650,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,17.5,8.8,"bone marrow: 17.5 nTPM (vital, limit 5); lymph node: 8.8 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 5); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NEK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 17.5 nTPM (vital, limit 5); lymph node: 8.8 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 5); small intestine: 6.7 nTPM (vital, limit 1); appendix: 5.1 nTPM (protected, limit 5); retina: 1.4 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000117868,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,43.3,49.2,"adipose tissue: 49.2 nTPM (protected, limit 5); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 5); esophagus: 39.3 nTPM (protected, limit 5); thyroid gland: 37.3 nTPM (protected, limit 5); colon: 37.1 nTPM (protected, limit 5); smooth muscle: 34.9 nTPM (vital, limit 2); urinary bladder: 33.7 nTPM (protected, limit 5); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); lung: 31.1 nTPM (vital, limit 1); parathyroid gland: 29.7 nTPM (protected, limit 5); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 5); lymph node: 25.7 nTPM (protected, limit 5); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 5); duodenum: 20.6 nTPM (vital, limit 1); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ESYT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 49.2 nTPM (protected, limit 5); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 5); esophagus: 39.3 nTPM (protected, limit 5); thyroid gland: 37.3 nTPM (protected, limit 5); colon: 37.1 nTPM (protected, limit 5); smooth muscle: 34.9 nTPM (vital, limit 2); urinary bladder: 33.7 nTPM (protected, limit 5); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); lung: 31.1 nTPM (vital, limit 1); gallbladder: 30.9 nTPM (protected, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 5); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 5); lymph node: 25.7 nTPM (protected, limit 5); pancreas: 25.1 nTPM (vital, limit 1); kidney: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); appendix: 22.6 nTPM (protected, limit 5); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 5); duodenum: 20.6 nTPM (vital, limit 1); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000117971,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CHRNB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025,False,False,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000118156,True,compatible,,True,0,2,partial,3,1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ZNF541,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000118193,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.5,3.1,"bone marrow: 6.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KIF14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 6.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000118245,True,compatible,,True,0,4,partial,2.3,2.3,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,TNP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000118307,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,13.9,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAI7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000118420,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,3.3,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,UBE3D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000118434,True,compatible,,True,0,1,partial,0.1,0,,,47,not_established,not_triggered,,,SPACA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000118491,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ZC2HC1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000118492,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,4.8,0.3,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),57,not_established,not_triggered,,,ADGB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000118596,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,33.2,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 5); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SLC16A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 5); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); gallbladder: 5.2 nTPM (protected, limit 5); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000118620,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.6,10.1,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 5); thyroid gland: 8.2 nTPM (protected, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 5); esophagus: 6.6 nTPM (protected, limit 5); cerebellum: 4.1 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF430,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 5); thyroid gland: 8.2 nTPM (protected, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 5); esophagus: 6.6 nTPM (protected, limit 5); appendix: 5.2 nTPM (protected, limit 5); cerebellum: 4.1 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000118965,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,13.1,13.9,"parathyroid gland: 13.9 nTPM (protected, limit 5); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,WDR35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 13.9 nTPM (protected, limit 5); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000118997,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,20.4,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 5); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAH7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 5); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000119231,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.9,11.7,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 5); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); urinary bladder: 8.7 nTPM (protected, limit 5); parathyroid gland: 8.5 nTPM (protected, limit 5); esophagus: 8.2 nTPM (protected, limit 5); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); stomach: 8 nTPM (protected, limit 5); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SENP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 5); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); urinary bladder: 8.7 nTPM (protected, limit 5); parathyroid gland: 8.5 nTPM (protected, limit 5); esophagus: 8.2 nTPM (protected, limit 5); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); appendix: 8.1 nTPM (protected, limit 5); stomach: 8 nTPM (protected, limit 5); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); gallbladder: 7 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000119547,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,9.9,0.8,"duodenum: 9.9 nTPM (vital, limit 5); liver: 8.2 nTPM (vital, limit 5); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),45,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,ONECUT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 9.9 nTPM (vital, limit 5); gallbladder: 9.8 nTPM (protected, limit 5); liver: 8.2 nTPM (vital, limit 5); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",gallbladder / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000119559,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,42.3,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (protected, limit 5); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 5); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); stomach: 17.3 nTPM (protected, limit 5); small intestine: 17.2 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 5); lymph node: 14.5 nTPM (protected, limit 5); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (protected, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,C19orf25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (protected, limit 5); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 5); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); stomach: 17.3 nTPM (protected, limit 5); small intestine: 17.2 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 5); lymph node: 14.5 nTPM (protected, limit 5); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (protected, limit 5); appendix: 8.4 nTPM (protected, limit 5); gallbladder: 7.8 nTPM (protected, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2)",appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000119661,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,17.3,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (protected, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 5); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 5); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,DNAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (protected, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 5); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); gallbladder: 8.6 nTPM (protected, limit 5); pituitary gland: 8.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 5); midbrain: 5.8 nTPM (vital, limit 1); appendix: 5.8 nTPM (protected, limit 5); tongue: 5.7 nTPM (protected, limit 5); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000119703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,8.5,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 5); pituitary gland: 6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 5); heart muscle: 5.1 nTPM (vital, limit 5); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZC2HC1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 5); pituitary gland: 6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 5); heart muscle: 5.1 nTPM (vital, limit 5); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000119725,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,57,32.4,"bone marrow: 57 nTPM (vital, limit 1); esophagus: 32.4 nTPM (protected, limit 5); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 5); urinary bladder: 28.1 nTPM (protected, limit 5); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (protected, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 5); lymph node: 25.1 nTPM (protected, limit 5); stomach: 24.9 nTPM (protected, limit 5); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (protected, limit 5); rectum: 23.4 nTPM (protected, limit 5); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 5); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF410,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 57 nTPM (vital, limit 1); esophagus: 32.4 nTPM (protected, limit 5); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 5); urinary bladder: 28.1 nTPM (protected, limit 5); adipose tissue: 28 nTPM (protected, limit 5); liver: 28 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 5); lymph node: 25.1 nTPM (protected, limit 5); stomach: 24.9 nTPM (protected, limit 5); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (protected, limit 5); rectum: 23.4 nTPM (protected, limit 5); retina: 22 nTPM (vital, limit 1); gallbladder: 21.5 nTPM (protected, limit 5); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); appendix: 18.4 nTPM (protected, limit 5); spinal cord: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 5); basal ganglia: 17.1 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120051,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,3.2,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120160,True,compatible,,True,0,2,partial,0.6,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,EQTN,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000120210,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,6.4,1,"retina: 6.4 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,INSL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 6.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120211,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,INSL4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000120215,False,excluded,positive_ihc_outside_permitted,True,0,6,partial,0.7,0.4,,retina / pigment epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,MLANA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,False,False,,retina / pigment epithelial cells: Medium (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000120262,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,11.4,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC170,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000120289,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,MAGEB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000120329,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,SLC25A2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000120334,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,9.3,6.3,"bone marrow: 9.3 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 5); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CENPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.3 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 5); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000120341,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,40,9,"liver: 40 nTPM (vital, limit 5); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 5); retina: 6.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SEC16B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 40 nTPM (vital, limit 5); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 5); retina: 6.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000120436,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,GPR31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000120440,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0.4,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,TTLL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"liver: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120451,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,24.4,21.5,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 5); thyroid gland: 20.9 nTPM (protected, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); pancreas: 18.9 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 5); stomach: 18.4 nTPM (protected, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 5); adipose tissue: 15.4 nTPM (protected, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); esophagus: 14.3 nTPM (protected, limit 5); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 5); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); duodenum: 11.4 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,SNX19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 5); thyroid gland: 20.9 nTPM (protected, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); pancreas: 18.9 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 5); stomach: 18.4 nTPM (protected, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 5); adipose tissue: 15.4 nTPM (protected, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); gallbladder: 14.3 nTPM (protected, limit 5); esophagus: 14.3 nTPM (protected, limit 5); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 5); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); appendix: 12 nTPM (protected, limit 5); duodenum: 11.4 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000120498,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,57,1.5,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,TEX11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120519,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7,9.6,"stomach: 9.6 nTPM (protected, limit 5); rectum: 8.9 nTPM (protected, limit 5); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 5); lymph node: 5.4 nTPM (protected, limit 5); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC10A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"stomach: 9.6 nTPM (protected, limit 5); rectum: 8.9 nTPM (protected, limit 5); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 5); lymph node: 5.4 nTPM (protected, limit 5); gallbladder: 5.4 nTPM (protected, limit 5); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120563,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,LYZL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000120616,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,147.7,22.5,"bone marrow: 147.7 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 5); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 5); retina: 18.7 nTPM (vital, limit 1); thyroid gland: 16.3 nTPM (protected, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 5); colon: 15.4 nTPM (protected, limit 5); urinary bladder: 14.7 nTPM (protected, limit 5); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); adipose tissue: 13.9 nTPM (protected, limit 5); pancreas: 13.9 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 5); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EPC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 147.7 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 5); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 5); retina: 18.7 nTPM (vital, limit 1); thyroid gland: 16.3 nTPM (protected, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 5); colon: 15.4 nTPM (protected, limit 5); urinary bladder: 14.7 nTPM (protected, limit 5); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (protected, limit 5); stomach: 13.6 nTPM (protected, limit 5); appendix: 13.5 nTPM (protected, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); gallbladder: 12.4 nTPM (protected, limit 5); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 5); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120659,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,4,12,"lymph node: 12 nTPM (protected, limit 5)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,TNFSF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 12 nTPM (protected, limit 5)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000120669,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,5.1,"tongue: 5.1 nTPM (protected, limit 5); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,SOHLH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Wang 2016;Loriot 2025,False,False,"tongue: 5.1 nTPM (protected, limit 5); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000120952,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000121039,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,83.6,66.6,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 5); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (protected, limit 5); liver: 39.7 nTPM (vital, limit 1); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 5); esophagus: 19.2 nTPM (protected, limit 5); colon: 16 nTPM (protected, limit 5); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 5); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 5); tongue: 7.9 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); adrenal gland: 6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RDH10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 5); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (protected, limit 5); liver: 39.7 nTPM (vital, limit 1); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); gallbladder: 29.2 nTPM (protected, limit 5); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 5); appendix: 22.7 nTPM (protected, limit 5); esophagus: 19.2 nTPM (protected, limit 5); colon: 16 nTPM (protected, limit 5); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 5); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 5); tongue: 7.9 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); adrenal gland: 6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000121101,True,compatible,,True,0,3,partial,1.7,0.1,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,TEX14,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000121152,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,34.8,19.9,"bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 5); rectum: 9 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 5); duodenum: 5.4 nTPM (vital, limit 5); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NCAPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 5); appendix: 9.7 nTPM (protected, limit 5); rectum: 9 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 5); duodenum: 5.4 nTPM (vital, limit 5); retina: 1.7 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000121207,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,2.1,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,LRAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000121211,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,13.1,11.7,"bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 5); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,MND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 5); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000121270,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ABCC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000121380,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,13.3,15,"rectum: 15 nTPM (protected, limit 10); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 10); pancreas: 5.2 nTPM (vital, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BCL2L14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"rectum: 15 nTPM (protected, limit 10); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 10); pancreas: 5.2 nTPM (vital, limit 5)",appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000121390,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,53.1,20.3,"bone marrow: 53.1 nTPM (vital, limit 1); lymph node: 20.3 nTPM (protected, limit 5); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 5); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 5); colon: 14.4 nTPM (protected, limit 5); hippocampal formation: 14.3 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 5); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 5); midbrain: 11 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (protected, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 5); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PSPC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 53.1 nTPM (vital, limit 1); lymph node: 20.3 nTPM (protected, limit 5); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 5); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 5); colon: 14.4 nTPM (protected, limit 5); hippocampal formation: 14.3 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 5); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); appendix: 12.8 nTPM (protected, limit 5); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 5); gallbladder: 11.7 nTPM (protected, limit 5); midbrain: 11 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (protected, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 5); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000121446,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,RGSL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000121570,True,compatible,,True,0,2,partial,4.7,0.5,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,DPPA4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,True,True,,,,unchanged
ENSG00000121621,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,8.1,4.5,"bone marrow: 8.1 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF18A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 8.1 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000121634,False,excluded,positive_ihc_outside_permitted,True,0,0,routine_complete,0.1,0,,eye / lens fiber cells: Medium (Enhanced),52,not_established,not_triggered,,,GJA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,False,False,,eye / lens fiber cells: Medium (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000121690,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,71.8,5,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DEPDC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000121903,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,2.5,2.5,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZSCAN20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000121904,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,CSMD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000121988,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZRANB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000122145,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,TBX22,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000122304,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.5,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus,PRM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"pituitary gland: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000122483,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,6.3,5.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 5); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCDC18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 5); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000122550,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,49,10.7,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 5); adipose tissue: 9.2 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); esophagus: 8.8 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 5); lymph node: 8.2 nTPM (protected, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 5); pancreas: 7.6 nTPM (vital, limit 1); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KLHL7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 5); liver: 10.1 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); gallbladder: 9.5 nTPM (protected, limit 5); tongue: 9.4 nTPM (protected, limit 5); adipose tissue: 9.2 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); esophagus: 8.8 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 5); lymph node: 8.2 nTPM (protected, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 5); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); appendix: 6.8 nTPM (protected, limit 5); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000122591,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,24.2,14.6,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 5); adipose tissue: 14.4 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 5); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 5); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HYCC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 5); adipose tissue: 14.4 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 5); gallbladder: 11 nTPM (protected, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 5); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 5); appendix: 8.3 nTPM (protected, limit 5); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000122728,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,TAF1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"retina: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000122778,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,6.2,2.4,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIAA1549,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000123165,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,ACTRT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000123171,True,compatible,,True,0,5,partial,0,0,,,43,not_established,not_triggered,,,CCDC70,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000123219,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,24.6,14.4,"bone marrow: 24.6 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 5); rectum: 11.5 nTPM (protected, limit 5); colon: 8.7 nTPM (protected, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CENPK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 24.6 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 5); rectum: 11.5 nTPM (protected, limit 5); appendix: 10.4 nTPM (protected, limit 5); colon: 8.7 nTPM (protected, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000123473,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.8,5.3,"bone marrow: 8.8 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,STIL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 8.8 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000123485,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,46.8,12.3,"bone marrow: 46.8 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 5); esophagus: 5.4 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,HJURP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 46.8 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 5); appendix: 5.4 nTPM (protected, limit 5); esophagus: 5.4 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000123496,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.7,4.3,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IL13RA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000123500,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,COL10A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"gallbladder: 8.6 nTPM (protected, limit 5); pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000123569,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,H2BW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000123576,True,compatible,,True,0,1,partial,0,0,,,47,not_established,not_triggered,,,ESX1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000123584,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEA9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000123594,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ATXN3L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000123975,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,174.7,100.3,"bone marrow: 174.7 nTPM (vital, limit 1); lymph node: 100.3 nTPM (protected, limit 5); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 5); colon: 42.6 nTPM (protected, limit 5); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 5); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 5); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 5); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (protected, limit 5); thyroid gland: 12.4 nTPM (protected, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CKS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 174.7 nTPM (vital, limit 1); lymph node: 100.3 nTPM (protected, limit 5); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 5); colon: 42.6 nTPM (protected, limit 5); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 5); appendix: 37.3 nTPM (protected, limit 5); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 5); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 5); gallbladder: 18.1 nTPM (protected, limit 5); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (protected, limit 5); thyroid gland: 12.4 nTPM (protected, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000123977,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,57.1,0.8,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DAW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000123999,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,73.2,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 5); pancreas: 11.9 nTPM (vital, limit 5); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 5); pituitary gland: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 5); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,INHA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 5); pancreas: 11.9 nTPM (vital, limit 5); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 5); pituitary gland: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 5); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000124089,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,2,partial,1.4,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),49,not_established,not_triggered,,,MC3R,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000124092,True,compatible,,True,0,2,partial,0.9,0.4,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CTCFL,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000124103,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.5,1.5,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM209A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000124116,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,WFDC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000124196,True,compatible,,True,0,1,partial,0.3,1.4,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,GTSF1L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000124198,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,19.6,78.8,"parathyroid gland: 78.8 nTPM (protected, limit 5); thyroid gland: 23.1 nTPM (protected, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 5); stomach: 15.8 nTPM (protected, limit 5); rectum: 15.2 nTPM (protected, limit 5); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 5); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); esophagus: 10.7 nTPM (protected, limit 5); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ARFGEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 78.8 nTPM (protected, limit 5); thyroid gland: 23.1 nTPM (protected, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 5); stomach: 15.8 nTPM (protected, limit 5); rectum: 15.2 nTPM (protected, limit 5); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 5); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); esophagus: 10.7 nTPM (protected, limit 5); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); appendix: 8.5 nTPM (protected, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); gallbladder: 8.3 nTPM (protected, limit 5); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000124227,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ANKRD60,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000124232,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,0,routine_complete,944.9,3.5,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),48,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,RBPJL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000124237,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,4,partial,24.7,0.1,"lung: 24.7 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; thymus,CIMIP1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"lung: 24.7 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000124260,True,compatible,,True,0,4,partial,0.3,0.2,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,MAGEA10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025,True,True,,,,unchanged
ENSG00000124449,True,compatible,,True,0,2,partial,0.1,0,,,47,not_established,not_triggered,,,IRGC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000124467,True,compatible,,True,0,3,partial,0,0.2,,,45,not_established,not_triggered,,,PSG8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000124490,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,16.5,3.5,"bone marrow: 16.5 nTPM (vital, limit 5); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,CRISP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 16.5 nTPM (vital, limit 5); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000124610,False,excluded,positive_ihc_outside_permitted;family_exclusion,True,0,5,partial,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H1-1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),positive_ihc_outside_permitted;family_exclusion,unchanged
ENSG00000124613,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,3.9,"cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF391,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000124678,True,compatible,,True,0,2,partial,0.5,0.3,,,48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,TCP11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000124721,True,compatible,,True,0,80,unavailable,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,DNAH8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,True,True,,,,unchanged
ENSG00000124812,True,compatible,,True,0,5,partial,0,0,,,42,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CRISP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000124818,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0.4,0.1,,retina / photoreceptor cells: High (Supported),56,not_established,not_triggered,,,OPN5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,retina / photoreceptor cells: High (Supported),positive_ihc_outside_permitted,unchanged
ENSG00000124900,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000125207,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.1,0.1,"retina: 1.1 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,PIWIL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000125245,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,9.6,38,"lymph node: 38 nTPM (protected, limit 5); bone marrow: 9.6 nTPM (vital, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,GPR18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 38 nTPM (protected, limit 5); appendix: 11.8 nTPM (protected, limit 10); bone marrow: 9.6 nTPM (vital, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000125319,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,9.2,2.7,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HROB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000125388,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,12.1,4.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); adrenal gland: 3.2 nTPM (vital, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GRK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); adrenal gland: 3.2 nTPM (vital, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000125409,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,2.5,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TEKT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000125531,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.7,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FNDC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"kidney: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000125533,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,BHLHE23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000125633,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,25.2,15.4,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 5); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (protected, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 5); rectum: 10.3 nTPM (protected, limit 5); lymph node: 10.1 nTPM (protected, limit 5); tongue: 9.9 nTPM (protected, limit 5); adipose tissue: 9.8 nTPM (protected, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CCDC93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 5); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (protected, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 5); rectum: 10.3 nTPM (protected, limit 5); lymph node: 10.1 nTPM (protected, limit 5); appendix: 10.1 nTPM (protected, limit 5); tongue: 9.9 nTPM (protected, limit 5); adipose tissue: 9.8 nTPM (protected, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); gallbladder: 6.9 nTPM (protected, limit 5)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000125788,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,DEFB126,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000125815,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CST8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000125816,True,compatible,,True,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,NKX2-4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000125823,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,not_triggered,,,CSTL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000125864,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,5.2,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,BFSP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000125888,False,excluded,rna_above_tissue_ceiling,True,0,5,partial,19.8,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,43,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,BANF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000125900,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,2.7,1.1,,kidney / cells in tubules: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,SIRPD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,kidney / cells in tubules: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000125903,True,compatible,existing_nomination_or_manual_review,True,0,1,partial,0,0,,,46,not_established,not_triggered,,,DEFB129,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000125965,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1.5,"lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus,GDF5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000125975,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,C20orf173,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000126216,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,12,partial,30.9,14.5,"bone marrow: 30.9 nTPM (vital, limit 1); lymph node: 14.5 nTPM (protected, limit 5); liver: 14.3 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (protected, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 5); esophagus: 10.4 nTPM (protected, limit 5); colon: 10.3 nTPM (protected, limit 5); thyroid gland: 10.3 nTPM (protected, limit 5); lung: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 5); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 5); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); parathyroid gland: 8.5 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TUBGCP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 30.9 nTPM (vital, limit 1); lymph node: 14.5 nTPM (protected, limit 5); liver: 14.3 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (protected, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); appendix: 11.8 nTPM (protected, limit 5); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 5); esophagus: 10.4 nTPM (protected, limit 5); thyroid gland: 10.3 nTPM (protected, limit 5); lung: 10.3 nTPM (vital, limit 1); colon: 10.3 nTPM (protected, limit 5); pancreas: 10.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 5); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 5); heart muscle: 9.1 nTPM (vital, limit 1); gallbladder: 8.6 nTPM (protected, limit 5); tongue: 8.6 nTPM (protected, limit 5); duodenum: 8.5 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 5); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000126246,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,48.7,32.3,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 5); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); urinary bladder: 6.9 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 5); rectum: 6.2 nTPM (protected, limit 5); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,IGFLR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 5); appendix: 18.5 nTPM (protected, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 5); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); urinary bladder: 6.9 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); colon: 6.2 nTPM (protected, limit 5); gallbladder: 5.9 nTPM (protected, limit 5); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000126467,True,compatible,,True,0,3,partial,1.4,1.1,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TSKS,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000126550,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,18,0,"pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,HTN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000126752,True,compatible,,True,0,2,partial,0.1,0.2,,,45,not_established,not_triggered,,,SSX1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000126787,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,17,partial,29.3,17.4,"bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DLGAP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 5); appendix: 7.9 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",appendix / endocrine cells: Medium (Enhanced); appendix / germinal center cells: Medium (Enhanced); appendix / non-germinal center cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000126856,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,PRDM7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000126890,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,2,partial,5.1,0.8,"heart muscle: 5.1 nTPM (vital, limit 5)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; thymus,CTAG2,current_adaptive,False,True,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,False,False,"heart muscle: 5.1 nTPM (vital, limit 5)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000127252,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,86.9,42.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 5); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 5); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,PLAAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 5); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 5); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127311,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HELB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127337,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,45.2,22,"bone marrow: 45.2 nTPM (vital, limit 1); lymph node: 22 nTPM (protected, limit 5); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 5); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (protected, limit 5); rectum: 13.3 nTPM (protected, limit 5); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 5); urinary bladder: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,YEATS4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 45.2 nTPM (vital, limit 1); lymph node: 22 nTPM (protected, limit 5); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 5); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (protected, limit 5); rectum: 13.3 nTPM (protected, limit 5); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 5); urinary bladder: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); appendix: 10.1 nTPM (protected, limit 5); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (protected, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); gallbladder: 8.1 nTPM (protected, limit 5); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127423,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.1,1.4,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AUNIP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127540,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,301.2,105.5,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 5); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 5); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 5); esophagus: 69.6 nTPM (protected, limit 5); adipose tissue: 68.8 nTPM (protected, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); urinary bladder: 58.9 nTPM (protected, limit 5); duodenum: 57.9 nTPM (vital, limit 1); thyroid gland: 51 nTPM (protected, limit 5); pancreas: 47.9 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 5); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 5); rectum: 22 nTPM (protected, limit 5); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,UQCR11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 5); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 5); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 5); esophagus: 69.6 nTPM (protected, limit 5); adipose tissue: 68.8 nTPM (protected, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); urinary bladder: 58.9 nTPM (protected, limit 5); duodenum: 57.9 nTPM (vital, limit 1); thyroid gland: 51 nTPM (protected, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 5); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 5); gallbladder: 24.1 nTPM (protected, limit 5); rectum: 22 nTPM (protected, limit 5); smooth muscle: 21.6 nTPM (vital, limit 1); appendix: 20 nTPM (protected, limit 5); retina: 13.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127564,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,27.3,11.2,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 5); lymph node: 7.8 nTPM (protected, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PKMYT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 5); lymph node: 7.8 nTPM (protected, limit 5); appendix: 6.5 nTPM (protected, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000127870,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,32.1,21.9,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); lymph node: 21.9 nTPM (protected, limit 5); parathyroid gland: 21.6 nTPM (protected, limit 5); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); adipose tissue: 18.3 nTPM (protected, limit 5); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); rectum: 17.9 nTPM (protected, limit 5); esophagus: 17.9 nTPM (protected, limit 5); colon: 17.8 nTPM (protected, limit 5); urinary bladder: 17.7 nTPM (protected, limit 5); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); thyroid gland: 16.9 nTPM (protected, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 5); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 5); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,RNF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); lymph node: 21.9 nTPM (protected, limit 5); parathyroid gland: 21.6 nTPM (protected, limit 5); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); adipose tissue: 18.3 nTPM (protected, limit 5); small intestine: 18.3 nTPM (vital, limit 1); appendix: 18.2 nTPM (protected, limit 5); cerebellum: 17.9 nTPM (vital, limit 2); rectum: 17.9 nTPM (protected, limit 5); esophagus: 17.9 nTPM (protected, limit 5); colon: 17.8 nTPM (protected, limit 5); urinary bladder: 17.7 nTPM (protected, limit 5); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); thyroid gland: 16.9 nTPM (protected, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 5); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 5); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); gallbladder: 13.3 nTPM (protected, limit 5); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000127928,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,1842.8,0.3,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,GNGT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000127993,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,14.1,8.2,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 5); pancreas: 8.2 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); adipose tissue: 8 nTPM (protected, limit 5); colon: 7.8 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); esophagus: 7.4 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 5); tongue: 6.7 nTPM (protected, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBM48,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 5); thyroid gland: 8.1 nTPM (protected, limit 5); adipose tissue: 8 nTPM (protected, limit 5); colon: 7.8 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); esophagus: 7.4 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 5); tongue: 6.7 nTPM (protected, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); appendix: 5.5 nTPM (protected, limit 5); duodenum: 5.2 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000128040,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,13.1,4.6,"bone marrow: 13.1 nTPM (vital, limit 5); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 5); pituitary gland: 4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPINK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 13.1 nTPM (vital, limit 5); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 5); pituitary gland: 4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000128059,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,6,8.2,"lymph node: 8.2 nTPM (protected, limit 5); urinary bladder: 6.5 nTPM (protected, limit 5); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 2); cerebral cortex: 5.5 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,PPAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 8.2 nTPM (protected, limit 5); urinary bladder: 6.5 nTPM (protected, limit 5); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (protected, limit 5); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 2); appendix: 5.2 nTPM (protected, limit 5); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000128271,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,15,partial,111,20,"basal ganglia: 111 nTPM (vital, limit 1); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 5); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 5); lung: 14.1 nTPM (vital, limit 5); heart muscle: 13.1 nTPM (vital, limit 5); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 5); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 5); spinal cord: 4.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,ADORA2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 111 nTPM (vital, limit 1); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 5); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 5); lung: 14.1 nTPM (vital, limit 5); appendix: 13.2 nTPM (protected, limit 5); heart muscle: 13.1 nTPM (vital, limit 5); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 5); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 5); spinal cord: 4.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",appendix / endocrine cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000128322,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,69.3,1.6,"bone marrow: 69.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,IGLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 69.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000128346,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.8,13.5,"esophagus: 13.5 nTPM (protected, limit 5); choroid plexus: 10.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,C22orf23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"esophagus: 13.5 nTPM (protected, limit 5); choroid plexus: 10.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); gallbladder: 6.1 nTPM (protected, limit 5); urinary bladder: 6 nTPM (protected, limit 5); skeletal muscle: 5.5 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000128394,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.1,15.2,"lymph node: 15.2 nTPM (protected, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,APOBEC3F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 15.2 nTPM (protected, limit 5); appendix: 8.9 nTPM (protected, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000128408,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,13,1.2,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RIBC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000128487,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,36.2,14.5,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 5); adipose tissue: 12.1 nTPM (protected, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 5); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); pituitary gland: 6.2 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SPECC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 5); gallbladder: 14.1 nTPM (protected, limit 5); adipose tissue: 12.1 nTPM (protected, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 5); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); appendix: 7.1 nTPM (protected, limit 5); pituitary gland: 6.2 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); skeletal muscle: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000128596,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,85.4,19.5,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 10); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 10); smooth muscle: 11.2 nTPM (vital, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC136,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 10); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 10); smooth muscle: 11.2 nTPM (vital, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000128610,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,13.4,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),49,not_established,not_triggered,,,FEZF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000128655,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,6.1,9.9,"parathyroid gland: 9.9 nTPM (protected, limit 5); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PDE11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 9.9 nTPM (protected, limit 5); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000128886,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,16.7,50.1,"lymph node: 50.1 nTPM (protected, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ELL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 50.1 nTPM (protected, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 5); appendix: 11.1 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); cerebellum: 1.2 nTPM (vital, limit 1)",appendix / lymphoid tissue: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000129221,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,1,partial,810,0.2,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,AIPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000129535,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,307.1,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NRL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000129559,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,290.2,278.8,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 5); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 5); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 5); adipose tissue: 163.6 nTPM (protected, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 5); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 5); pituitary gland: 140.1 nTPM (vital, limit 1); thyroid gland: 128.8 nTPM (protected, limit 5); small intestine: 125.2 nTPM (vital, limit 1); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 5); lymph node: 79.1 nTPM (protected, limit 5); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NEDD8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 5); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 5); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 5); adipose tissue: 163.6 nTPM (protected, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 5); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 5); pituitary gland: 140.1 nTPM (vital, limit 1); thyroid gland: 128.8 nTPM (protected, limit 5); small intestine: 125.2 nTPM (vital, limit 1); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 5); lymph node: 79.1 nTPM (protected, limit 5); retina: 72.2 nTPM (vital, limit 1); appendix: 69.4 nTPM (protected, limit 5); duodenum: 54.2 nTPM (vital, limit 1); gallbladder: 49.3 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000129646,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,7.3,4.2,"cerebellum: 7.3 nTPM (vital, limit 5); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,QRICH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 7.3 nTPM (vital, limit 5); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000129673,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.6,1.5,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,AANAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000129810,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,8.6,6.1,"bone marrow: 8.6 nTPM (vital, limit 5); lymph node: 6.1 nTPM (protected, limit 5); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,SGO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 8.6 nTPM (vital, limit 5); lymph node: 6.1 nTPM (protected, limit 5); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",appendix / enterocytes: Medium (Enhanced); appendix / germinal center cells: Low (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000129862,True,compatible,,True,0,1,partial,0,0,,,47,not_established,not_triggered,,,VCY1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000129864,True,compatible,,True,0,7,partial,0,0,,,46,not_established,not_triggered,,,VCY,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000129873,True,compatible,,True,0,2,partial,0,0,,,44,not_established,not_triggered,,,CDY2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000130167,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,5.1,0.1,"bone marrow: 5.1 nTPM (vital, limit 5)",adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,TSPAN16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 5.1 nTPM (vital, limit 5)",adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000130234,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,237.9,9.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 5); colon: 9.6 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); liver: 5.6 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); gallbladder: 64.1 nTPM (protected, limit 5); heart muscle: 41.3 nTPM (vital, limit 5); colon: 9.6 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); liver: 5.6 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",appendix / enterocytes: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); gallbladder / glandular cells: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000130270,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.8,0.7,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ATP8B3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000130377,True,compatible,,True,0,1,partial,0.5,0.1,,,47,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ACSBG2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000130383,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,FUT5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000130385,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,BMP15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000130518,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,3.4,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IQCN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000130544,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.7,2.5,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF557,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000130561,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,1421.5,0,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SAG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000130656,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.9,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,HBZ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000130783,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,1.4,0.3,"retina: 1.4 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000130810,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,31.6,27,"skeletal muscle: 31.6 nTPM (vital, limit 1); esophagus: 27 nTPM (protected, limit 5); liver: 23.9 nTPM (vital, limit 1); pancreas: 22.5 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); urinary bladder: 19.8 nTPM (protected, limit 5); adrenal gland: 19.8 nTPM (vital, limit 1); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 5); stomach: 17.8 nTPM (protected, limit 5); lymph node: 17.2 nTPM (protected, limit 5); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); thyroid gland: 15.5 nTPM (protected, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 5); parathyroid gland: 8 nTPM (protected, limit 5); smooth muscle: 6.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PPAN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 31.6 nTPM (vital, limit 1); esophagus: 27 nTPM (protected, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 5); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 5); stomach: 17.8 nTPM (protected, limit 5); lymph node: 17.2 nTPM (protected, limit 5); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); thyroid gland: 15.5 nTPM (protected, limit 5); appendix: 15.2 nTPM (protected, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 5); parathyroid gland: 8 nTPM (protected, limit 5); smooth muscle: 6.4 nTPM (vital, limit 1); gallbladder: 6.3 nTPM (protected, limit 5); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000130943,True,compatible,,True,0,5,partial,0.3,0.1,,,45,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,PKDREJ,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,True,True,,,,unchanged
ENSG00000130948,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,14.8,9.7,"liver: 14.8 nTPM (vital, limit 5); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,HSD17B3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 14.8 nTPM (vital, limit 5); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000130950,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,NUTM2F,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000131019,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,6.3,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ULBP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000131044,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,TTLL9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000131050,True,compatible,,True,0,5,partial,3.8,0.3,,,46,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,BPIFA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000131059,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,BPIFA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000131068,True,compatible,existing_nomination_or_manual_review,True,0,2,partial,0,0,,,46,not_established,not_triggered,,,DEFB118,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000131115,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,9.8,10.1,"lymph node: 10.1 nTPM (protected, limit 5); parathyroid gland: 10 nTPM (protected, limit 5); cerebellum: 9.8 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 5); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 5); pancreas: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); adipose tissue: 6.1 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ZNF227,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 10.1 nTPM (protected, limit 5); parathyroid gland: 10 nTPM (protected, limit 5); cerebellum: 9.8 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 5); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 5); pancreas: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); adipose tissue: 6.1 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); gallbladder: 5.7 nTPM (protected, limit 5); appendix: 5.7 nTPM (protected, limit 5); rectum: 5.6 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000131126,True,compatible,,True,0,6,partial,1.5,1.2,,,42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TEX101,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000131379,True,compatible,,True,0,80,unavailable,0.4,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; thymus; tonsil,C3orf20,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000131495,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,274,223.4,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 5); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); parathyroid gland: 96.2 nTPM (protected, limit 5); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 5); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 5); pituitary gland: 77 nTPM (vital, limit 1); adipose tissue: 73.4 nTPM (protected, limit 5); esophagus: 71.4 nTPM (protected, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 5); thyroid gland: 62.2 nTPM (protected, limit 5); rectum: 59 nTPM (protected, limit 5); urinary bladder: 53.4 nTPM (protected, limit 5); lung: 51.7 nTPM (vital, limit 1); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NDUFA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 5); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); parathyroid gland: 96.2 nTPM (protected, limit 5); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 5); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 5); pituitary gland: 77 nTPM (vital, limit 1); adipose tissue: 73.4 nTPM (protected, limit 5); esophagus: 71.4 nTPM (protected, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 5); thyroid gland: 62.2 nTPM (protected, limit 5); rectum: 59 nTPM (protected, limit 5); urinary bladder: 53.4 nTPM (protected, limit 5); lung: 51.7 nTPM (vital, limit 1); appendix: 50.8 nTPM (protected, limit 5); retina: 50.2 nTPM (vital, limit 1); gallbladder: 44.2 nTPM (protected, limit 5); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000131721,True,compatible,,True,0,1,partial,0.2,0,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,RHOXF2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000131738,True,compatible,,True,0,6,partial,0.4,0.7,,,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,KRT33B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000131747,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,41.5,39.4,"bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 5); esophagus: 28.2 nTPM (protected, limit 5); rectum: 19.1 nTPM (protected, limit 5); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 5); small intestine: 16.5 nTPM (vital, limit 1); stomach: 8.6 nTPM (protected, limit 5); smooth muscle: 7.3 nTPM (vital, limit 5); urinary bladder: 5.8 nTPM (protected, limit 5); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TOP2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 5); esophagus: 28.2 nTPM (protected, limit 5); appendix: 19.4 nTPM (protected, limit 5); rectum: 19.1 nTPM (protected, limit 5); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 5); small intestine: 16.5 nTPM (vital, limit 1); stomach: 8.6 nTPM (protected, limit 5); smooth muscle: 7.3 nTPM (vital, limit 5); urinary bladder: 5.8 nTPM (protected, limit 5); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000131773,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,51.4,29.9,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 5); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (protected, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 5); liver: 11.9 nTPM (vital, limit 5); urinary bladder: 10.2 nTPM (protected, limit 5); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 5); lung: 8.5 nTPM (vital, limit 5); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); stomach: 6.7 nTPM (protected, limit 5); pituitary gland: 6.6 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KHDRBS3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 5); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (protected, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 5); liver: 11.9 nTPM (vital, limit 5); gallbladder: 11.1 nTPM (protected, limit 5); urinary bladder: 10.2 nTPM (protected, limit 5); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 5); lung: 8.5 nTPM (vital, limit 5); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); stomach: 6.7 nTPM (protected, limit 5); pituitary gland: 6.6 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); appendix: 5.5 nTPM (protected, limit 5); thyroid gland: 5.4 nTPM (protected, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / endocrine cells: Medium (Enhanced); appendix / enterocytes: Low (Enhanced); appendix / germinal center cells: Low (Enhanced); appendix / goblet cells: Low (Enhanced); appendix / non-germinal center cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000131848,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,5.6,3.6,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ZSCAN5A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000131864,True,compatible,,True,0,7,partial,1.6,0.3,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,USP29,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000131914,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0.3,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,LIN28A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000131951,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,LRRC9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"choroid plexus: 2.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132016,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,5.1,5.3,"esophagus: 5.3 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BRME1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"esophagus: 5.3 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000132122,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.8,10.3,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 5); thyroid gland: 9.2 nTPM (protected, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); spinal cord: 6.5 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (protected, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 5); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPATA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 5); thyroid gland: 9.2 nTPM (protected, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); spinal cord: 6.5 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (protected, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 5); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132141,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,4.9,3.6,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCT6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000132436,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,9.4,9.9,"lymph node: 9.9 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 5); basal ganglia: 4.5 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FIGNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 9.9 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); appendix: 8 nTPM (protected, limit 5); tongue: 7.7 nTPM (protected, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 5); basal ganglia: 4.5 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000132446,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,FTHL17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000132464,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.6,1.8,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENAM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132554,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.4,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,RGS22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132631,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SCP2D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000132681,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,4.9,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ATP1A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132749,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.4,2.9,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TESMIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132932,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,19.7,0.6,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ATP8A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000132950,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,12.1,10,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (protected, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); esophagus: 7.4 nTPM (protected, limit 5); tongue: 7.4 nTPM (protected, limit 5); stomach: 7.1 nTPM (protected, limit 5); urinary bladder: 6.9 nTPM (protected, limit 5); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (protected, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 5); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZMYM5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 5); gallbladder: 8.9 nTPM (protected, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (protected, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); esophagus: 7.4 nTPM (protected, limit 5); tongue: 7.4 nTPM (protected, limit 5); stomach: 7.1 nTPM (protected, limit 5); urinary bladder: 6.9 nTPM (protected, limit 5); appendix: 6.9 nTPM (protected, limit 5); adipose tissue: 6.7 nTPM (protected, limit 5); liver: 6.7 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 5); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000132953,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,42.8,16.2,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 5); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); thyroid gland: 6.3 nTPM (protected, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,XPO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 5); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 5); thyroid gland: 6.3 nTPM (protected, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); appendix: 5.6 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000132958,True,compatible,,True,0,80,unavailable,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,TPTE2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000132972,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,0.3,0.1,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,RNF17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000133019,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,10.3,7.2,"pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); urinary bladder: 6.8 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CHRM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); urinary bladder: 6.8 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000133101,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,11.9,21.5,"parathyroid gland: 21.5 nTPM (protected, limit 10); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 5); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 5); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCNA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"parathyroid gland: 21.5 nTPM (protected, limit 10); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 5); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 5); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000133111,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7,6.6,"cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 5); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RFXAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 5); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000133477,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,13.1,19.7,"esophagus: 19.7 nTPM (protected, limit 10); pancreas: 13.1 nTPM (vital, limit 5); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,FAM83F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"esophagus: 19.7 nTPM (protected, limit 10); pancreas: 13.1 nTPM (vital, limit 5); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000133640,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13.6,2.9,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen; thymus,LRRIQ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000133816,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,199.5,28.6,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 5); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 5); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 5); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 5); amygdala: 16.7 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 5); thyroid gland: 8.7 nTPM (protected, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MICAL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 5); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 5); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 5); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 5); amygdala: 16.7 nTPM (vital, limit 1); appendix: 15.1 nTPM (protected, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); gallbladder: 13.6 nTPM (protected, limit 5); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 5); thyroid gland: 8.7 nTPM (protected, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000133863,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,5.1,0.4,"smooth muscle: 5.1 nTPM (vital, limit 5)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,TEX15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"smooth muscle: 5.1 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000133962,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.4,1.4,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CATSPERB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000133980,True,compatible,,True,0,80,unavailable,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,VRTN,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000134007,True,compatible,,True,0,1,partial,0.4,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ADAM20,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000134046,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,20.1,31.3,"lymph node: 31.3 nTPM (protected, limit 5); thyroid gland: 30.1 nTPM (protected, limit 5); esophagus: 28.7 nTPM (protected, limit 5); adipose tissue: 25.9 nTPM (protected, limit 5); urinary bladder: 20.2 nTPM (protected, limit 5); bone marrow: 20.1 nTPM (vital, limit 1); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 5); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); lung: 15.9 nTPM (vital, limit 1); parathyroid gland: 15.9 nTPM (protected, limit 5); rectum: 15.9 nTPM (protected, limit 5); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 5); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MBD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 31.3 nTPM (protected, limit 5); thyroid gland: 30.1 nTPM (protected, limit 5); esophagus: 28.7 nTPM (protected, limit 5); adipose tissue: 25.9 nTPM (protected, limit 5); urinary bladder: 20.2 nTPM (protected, limit 5); bone marrow: 20.1 nTPM (vital, limit 1); appendix: 18.7 nTPM (protected, limit 5); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 5); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); lung: 15.9 nTPM (vital, limit 1); parathyroid gland: 15.9 nTPM (protected, limit 5); rectum: 15.9 nTPM (protected, limit 5); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 5); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); gallbladder: 11.1 nTPM (protected, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134049,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,13,partial,30.3,20.9,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 5); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 5); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 5); thyroid gland: 15.4 nTPM (protected, limit 5); small intestine: 15.3 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); urinary bladder: 13.4 nTPM (protected, limit 5); pancreas: 13.2 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (protected, limit 5); rectum: 12.6 nTPM (protected, limit 5); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 5); lymph node: 11.1 nTPM (protected, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,IER3IP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 5); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 5); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 5); thyroid gland: 15.4 nTPM (protected, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); urinary bladder: 13.4 nTPM (protected, limit 5); pancreas: 13.2 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (protected, limit 5); rectum: 12.6 nTPM (protected, limit 5); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 5); appendix: 11.5 nTPM (protected, limit 5); lymph node: 11.1 nTPM (protected, limit 5); gallbladder: 9.9 nTPM (protected, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134146,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,13.8,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (protected, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 5); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 5); adipose tissue: 8.3 nTPM (protected, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 5); tongue: 6.6 nTPM (protected, limit 5); colon: 6.5 nTPM (protected, limit 5); stomach: 6.5 nTPM (protected, limit 5); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); duodenum: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,DPH6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (protected, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 5); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 5); adipose tissue: 8.3 nTPM (protected, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 5); tongue: 6.6 nTPM (protected, limit 5); colon: 6.5 nTPM (protected, limit 5); stomach: 6.5 nTPM (protected, limit 5); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); gallbladder: 5.8 nTPM (protected, limit 5); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134160,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,17,0,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,TRPM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000134215,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,81,49.2,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 5); colon: 39.9 nTPM (protected, limit 5); esophagus: 33.8 nTPM (protected, limit 5); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 5); lymph node: 10.1 nTPM (protected, limit 5); thyroid gland: 9.6 nTPM (protected, limit 5); duodenum: 9 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); retina: 7.1 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,VAV3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 5); colon: 39.9 nTPM (protected, limit 5); esophagus: 33.8 nTPM (protected, limit 5); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 5); appendix: 10.5 nTPM (protected, limit 5); lymph node: 10.1 nTPM (protected, limit 5); thyroid gland: 9.6 nTPM (protected, limit 5); duodenum: 9 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); retina: 7.1 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134249,True,compatible,,True,0,1,partial,0,0,,,46,not_established,not_triggered,,,ADAM30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000134256,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,6.5,2.3,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,CD101,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134376,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,72.4,0.4,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),56,not_established,required,lymphatic_and_immune_function_review,lymph node,CRB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000134389,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,1,partial,162,0,"liver: 162 nTPM (vital, limit 3)",,48,not_established,not_triggered,,,CFHR5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"liver: 162 nTPM (vital, limit 3)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000134490,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.8,2.3,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TMEM241,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000134588,True,compatible,,True,0,3,partial,0,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,USP26,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000134595,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,SOX3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000134640,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,0.3,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,MTNR1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,False,False,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000134690,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,33.1,19,"bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 5); rectum: 10.9 nTPM (protected, limit 5); colon: 9.1 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,CDCA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 5); rectum: 10.9 nTPM (protected, limit 5); colon: 9.1 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); duodenum: 8.1 nTPM (vital, limit 1); appendix: 7.7 nTPM (protected, limit 5); small intestine: 7.1 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / endocrine cells: High (Enhanced); appendix / enterocytes: Low (Enhanced); appendix / germinal center cells: High (Enhanced); appendix / goblet cells: Low (Enhanced); appendix / non-germinal center cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000134758,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,94.8,23.6,"bone marrow: 94.8 nTPM (vital, limit 1); lymph node: 23.6 nTPM (protected, limit 5); colon: 22.7 nTPM (protected, limit 5); liver: 21 nTPM (vital, limit 1); rectum: 19.6 nTPM (protected, limit 5); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 5); stomach: 13.8 nTPM (protected, limit 5); adipose tissue: 13.2 nTPM (protected, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 5); thyroid gland: 11.5 nTPM (protected, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RNF138,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 94.8 nTPM (vital, limit 1); lymph node: 23.6 nTPM (protected, limit 5); colon: 22.7 nTPM (protected, limit 5); liver: 21 nTPM (vital, limit 1); rectum: 19.6 nTPM (protected, limit 5); appendix: 16.9 nTPM (protected, limit 5); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 5); stomach: 13.8 nTPM (protected, limit 5); adipose tissue: 13.2 nTPM (protected, limit 5); gallbladder: 13.1 nTPM (protected, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 5); thyroid gland: 11.5 nTPM (protected, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000134940,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,2.4,0.4,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,46,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ACRV1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000134970,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,77.9,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (protected, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 5); smooth muscle: 43.4 nTPM (vital, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 5); colon: 40.7 nTPM (protected, limit 5); stomach: 40.4 nTPM (protected, limit 5); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 5); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (protected, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 5); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); tongue: 23.8 nTPM (protected, limit 5); lymph node: 22.9 nTPM (protected, limit 5); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); retina: 18.6 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TMED7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (protected, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 5); smooth muscle: 43.4 nTPM (vital, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 5); colon: 40.7 nTPM (protected, limit 5); stomach: 40.4 nTPM (protected, limit 5); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 5); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (protected, limit 5); gallbladder: 32.4 nTPM (protected, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 5); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); appendix: 28.7 nTPM (protected, limit 5); pituitary gland: 27.2 nTPM (vital, limit 1); tongue: 23.8 nTPM (protected, limit 5); lymph node: 22.9 nTPM (protected, limit 5); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); retina: 18.6 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000135119,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,10.9,1,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,RNFT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000135175,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OCM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000135222,True,compatible,,True,0,0,routine_complete,0.1,0,,,48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,CSN2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000135248,True,compatible,,True,0,80,unavailable,1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,GARIN1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000135314,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,14.2,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KHDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000135334,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,94,40.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); tongue: 40.9 nTPM (protected, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 5); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (protected, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 5); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 5); small intestine: 22.3 nTPM (vital, limit 1); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 5); parathyroid gland: 17.2 nTPM (protected, limit 5); thyroid gland: 16.7 nTPM (protected, limit 5); stomach: 16.3 nTPM (protected, limit 5); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AKIRIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); tongue: 40.9 nTPM (protected, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 5); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (protected, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 5); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); appendix: 23.1 nTPM (protected, limit 5); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 5); small intestine: 22.3 nTPM (vital, limit 1); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 5); parathyroid gland: 17.2 nTPM (protected, limit 5); thyroid gland: 16.7 nTPM (protected, limit 5); stomach: 16.3 nTPM (protected, limit 5); smooth muscle: 15.8 nTPM (vital, limit 1); gallbladder: 14.8 nTPM (protected, limit 5); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000135338,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,13.9,16.7,"parathyroid gland: 16.7 nTPM (protected, limit 5); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (protected, limit 5); spinal cord: 6 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LCA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 16.7 nTPM (protected, limit 5); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (protected, limit 5); spinal cord: 6 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); appendix / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000135355,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.7,0,,,0,not_established,not_triggered,,,GJA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000135436,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.5,1,"pancreas: 1.5 nTPM (vital, limit 1)",,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM186B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,False,False,"pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000135451,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,50.5,13.2,"bone marrow: 50.5 nTPM (vital, limit 1); esophagus: 13.2 nTPM (protected, limit 5); lymph node: 11 nTPM (protected, limit 5); rectum: 8.9 nTPM (protected, limit 5); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 5); stomach: 5.2 nTPM (protected, limit 5); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TROAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 50.5 nTPM (vital, limit 1); esophagus: 13.2 nTPM (protected, limit 5); lymph node: 11 nTPM (protected, limit 5); rectum: 8.9 nTPM (protected, limit 5); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); appendix: 7.1 nTPM (protected, limit 5); colon: 6.5 nTPM (protected, limit 5); stomach: 5.2 nTPM (protected, limit 5); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000135537,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,4.8,5.1,"parathyroid gland: 5.1 nTPM (protected, limit 5); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AFG1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 5.1 nTPM (protected, limit 5); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000135577,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,NMBR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000135625,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,18.6,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),49,not_established,required,in_situ_inflammation_review,appendix,EGR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000135824,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,29.5,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,RGS8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000135829,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,129.8,66,"bone marrow: 129.8 nTPM (vital, limit 1); parathyroid gland: 66 nTPM (protected, limit 5); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 5); urinary bladder: 52 nTPM (protected, limit 5); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (protected, limit 5); rectum: 45.7 nTPM (protected, limit 5); colon: 38.9 nTPM (protected, limit 5); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (protected, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 5); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 5); duodenum: 31.7 nTPM (vital, limit 1); esophagus: 31.2 nTPM (protected, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DHX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 129.8 nTPM (vital, limit 1); parathyroid gland: 66 nTPM (protected, limit 5); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 5); urinary bladder: 52 nTPM (protected, limit 5); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (protected, limit 5); appendix: 46.1 nTPM (protected, limit 5); rectum: 45.7 nTPM (protected, limit 5); colon: 38.9 nTPM (protected, limit 5); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (protected, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 5); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 5); duodenum: 31.7 nTPM (vital, limit 1); esophagus: 31.2 nTPM (protected, limit 5); gallbladder: 30.1 nTPM (protected, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000135898,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.5,2.8,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GPR55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000135913,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,11.5,5.8,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,USP37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000135951,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TSGA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000135960,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,1,3.5,,adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,EDAR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000136014,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.9,1.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,USP44,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000136197,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,2.4,2.7,"kidney: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C7orf25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000136206,True,compatible,,True,0,3,partial,1.5,0.6,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SPDYE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000136231,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,0.7,4.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,IGF2BP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Bradley 2020,False,False,,adrenal gland / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000136327,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.6,2.5,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,NKX2-8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000136449,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,5,0.9,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MYCBPAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000136487,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,99.7,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,GH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000136488,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,38.3,19.4,"smooth muscle: 38.3 nTPM (vital, limit 5); stomach: 19.4 nTPM (protected, limit 10); lung: 10.4 nTPM (vital, limit 5)",pituitary gland / cells in anterior : High (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen; thymus; tonsil,CSH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"smooth muscle: 38.3 nTPM (vital, limit 5); stomach: 19.4 nTPM (protected, limit 10); lung: 10.4 nTPM (vital, limit 5)",pituitary gland / cells in anterior : High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000136492,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,10,partial,2.7,1.3,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,BRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000136603,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,23,20.6,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 5); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 5); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 5); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 5); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (protected, limit 5); thyroid gland: 11 nTPM (protected, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 5); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); retina: 9.3 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); midbrain: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,SKIL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 5); gallbladder: 20.5 nTPM (protected, limit 5); appendix: 18.3 nTPM (protected, limit 5); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 5); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 5); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 5); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (protected, limit 5); thyroid gland: 11 nTPM (protected, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 5); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); retina: 9.3 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); midbrain: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000136811,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,36.6,17.5,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 5); pituitary gland: 29.8 nTPM (vital, limit 1); bone marrow: 22.3 nTPM (vital, limit 5); lymph node: 17.5 nTPM (protected, limit 10); urinary bladder: 16.1 nTPM (protected, limit 10); liver: 16 nTPM (vital, limit 5); colon: 14.6 nTPM (protected, limit 5); smooth muscle: 13.8 nTPM (vital, limit 5); kidney: 13.7 nTPM (vital, limit 5); lung: 13.6 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 10); stomach: 13 nTPM (protected, limit 10); small intestine: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (protected, limit 10); heart muscle: 12.5 nTPM (vital, limit 5); esophagus: 11.5 nTPM (protected, limit 10); pancreas: 11.5 nTPM (vital, limit 5); cerebral cortex: 11.1 nTPM (vital, limit 5); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 5); adrenal gland: 9.7 nTPM (vital, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 5); duodenum: 7.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ODF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 5); pituitary gland: 29.8 nTPM (vital, limit 1); bone marrow: 22.3 nTPM (vital, limit 5); lymph node: 17.5 nTPM (protected, limit 10); urinary bladder: 16.1 nTPM (protected, limit 10); liver: 16 nTPM (vital, limit 5); appendix: 14.9 nTPM (protected, limit 5); colon: 14.6 nTPM (protected, limit 5); smooth muscle: 13.8 nTPM (vital, limit 5); kidney: 13.7 nTPM (vital, limit 5); lung: 13.6 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 10); stomach: 13 nTPM (protected, limit 10); small intestine: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (protected, limit 10); heart muscle: 12.5 nTPM (vital, limit 5); pancreas: 11.5 nTPM (vital, limit 5); esophagus: 11.5 nTPM (protected, limit 10); cerebral cortex: 11.1 nTPM (vital, limit 5); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 5); adrenal gland: 9.7 nTPM (vital, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 5); duodenum: 7.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000136866,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.1,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZFP37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000136929,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,243.6,1.5,"bone marrow: 243.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HEMGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"bone marrow: 243.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000136944,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,1,"midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,LMX1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000137090,True,compatible,,True,0,2,partial,0.3,0.2,,,47,not_established,not_triggered,,,DMRT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000137225,True,compatible,,True,0,3,partial,0.4,1.5,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CAPN11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000137270,True,compatible,,True,0,5,partial,3.4,0.2,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,GCM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000137434,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.3,1.5,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C6orf52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000137473,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,5.9,0.6,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),47,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,TTC29,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000137674,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,MMP20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000137691,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,23.6,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP300,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000137707,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.3,0,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,BTG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 4.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000137770,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,20.2,18.9,"bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 5); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 5); urinary bladder: 11.8 nTPM (protected, limit 5); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.7 nTPM (protected, limit 5); colon: 10.5 nTPM (protected, limit 5); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 5); cerebellum: 9 nTPM (vital, limit 2); adipose tissue: 8.7 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,CTDSPL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 5); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); appendix: 12.6 nTPM (protected, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 5); urinary bladder: 11.8 nTPM (protected, limit 5); gallbladder: 11.5 nTPM (protected, limit 5); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.7 nTPM (protected, limit 5); colon: 10.5 nTPM (protected, limit 5); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 5); cerebellum: 9 nTPM (vital, limit 2); adipose tissue: 8.7 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000137812,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,5.1,3.5,"bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000137843,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,31.8,24.9,"cerebral cortex: 31.8 nTPM (vital, limit 1); esophagus: 24.9 nTPM (protected, limit 5); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 5); thyroid gland: 7.2 nTPM (protected, limit 5); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,PAK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"cerebral cortex: 31.8 nTPM (vital, limit 1); esophagus: 24.9 nTPM (protected, limit 5); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 5); thyroid gland: 7.2 nTPM (protected, limit 5); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000137869,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,8.2,8,"adrenal gland: 8.2 nTPM (vital, limit 5)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,CYP19A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"adrenal gland: 8.2 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000137948,False,excluded,rna_above_tissue_ceiling,True,0,6,partial,2.6,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,BRDT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 2.6 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000137968,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,6.4,"esophagus: 6.4 nTPM (protected, limit 5); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC44A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 6.4 nTPM (protected, limit 5); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000137976,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,0.7,"lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,DNASE2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000138068,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0.2,,,0,not_established,not_triggered,,,SULT6B1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000138092,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.1,5.1,"bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (protected, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CENPO,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (protected, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000138115,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,2088.7,5.8,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,CYP2C8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000138182,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,10.1,7.8,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF20B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000138336,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0.7,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TET1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000138379,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,9.7,14.7,"tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,MSTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000138380,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,15.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (protected, limit 5); lymph node: 8.6 nTPM (protected, limit 5); parathyroid gland: 7.6 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); urinary bladder: 5.5 nTPM (protected, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); tongue: 5.2 nTPM (protected, limit 5); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CARF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (protected, limit 5); lymph node: 8.6 nTPM (protected, limit 5); parathyroid gland: 7.6 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 5); gallbladder: 5.8 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); appendix: 5.6 nTPM (protected, limit 5); urinary bladder: 5.5 nTPM (protected, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); tongue: 5.2 nTPM (protected, limit 5); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000138400,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,20.3,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MDH1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000138483,True,compatible,,True,0,80,unavailable,0.7,0.1,,,0,not_established,not_triggered,,,CCDC54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000138587,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,22,2.8,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MNS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000138646,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,18.6,9.3,"bone marrow: 18.6 nTPM (vital, limit 3); smooth muscle: 13 nTPM (vital, limit 3); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 7.5); pancreas: 7.5 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,HERC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 18.6 nTPM (vital, limit 3); smooth muscle: 13 nTPM (vital, limit 3); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 7.5); pancreas: 7.5 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000138669,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,13.3,2.9,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PRKG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000138684,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,0,5.8,"lymph node: 5.8 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,IL21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,"lymph node: 5.8 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000138688,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,60.4,40.9,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 5); skeletal muscle: 40.1 nTPM (vital, limit 2); spinal cord: 40.1 nTPM (vital, limit 1); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 5); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (protected, limit 5); colon: 28.6 nTPM (protected, limit 5); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (protected, limit 5); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 5); stomach: 22.5 nTPM (protected, limit 5); heart muscle: 22.1 nTPM (vital, limit 1); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 5); rectum: 14 nTPM (protected, limit 5); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 5); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,BLTP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 5); skeletal muscle: 40.1 nTPM (vital, limit 2); spinal cord: 40.1 nTPM (vital, limit 1); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 5); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (protected, limit 5); colon: 28.6 nTPM (protected, limit 5); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (protected, limit 5); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); kidney: 24.6 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); pancreas: 24 nTPM (vital, limit 1); urinary bladder: 23.7 nTPM (protected, limit 5); stomach: 22.5 nTPM (protected, limit 5); heart muscle: 22.1 nTPM (vital, limit 1); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 5); rectum: 14 nTPM (protected, limit 5); smooth muscle: 13.8 nTPM (vital, limit 1); gallbladder: 12.4 nTPM (protected, limit 5); lymph node: 11.6 nTPM (protected, limit 5); duodenum: 11.6 nTPM (vital, limit 1); appendix: 8 nTPM (protected, limit 5)",appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000138778,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,9.9,5.5,"bone marrow: 9.9 nTPM (vital, limit 1); lymph node: 5.5 nTPM (protected, limit 5); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CENPE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.9 nTPM (vital, limit 1); lymph node: 5.5 nTPM (protected, limit 5); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000138780,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,7.1,5.2,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,GSTCD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000138813,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C4orf17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000138892,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TTLL8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000139133,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,4,3.6,"bone marrow: 4 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ALG10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000139151,True,compatible,,True,0,80,unavailable,0.4,0.4,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,PLCZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000139160,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,9.4,7.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 5); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ETFBKMT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 5); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000139163,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,22.7,43.9,"stomach: 43.9 nTPM (protected, limit 5); colon: 26.3 nTPM (protected, limit 5); duodenum: 22.7 nTPM (vital, limit 1); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 5); cerebral cortex: 16.4 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); rectum: 14.9 nTPM (protected, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (protected, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); parathyroid gland: 10.5 nTPM (protected, limit 5); esophagus: 10.5 nTPM (protected, limit 5); urinary bladder: 10.4 nTPM (protected, limit 5); pancreas: 10.4 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (protected, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ETNK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"stomach: 43.9 nTPM (protected, limit 5); colon: 26.3 nTPM (protected, limit 5); duodenum: 22.7 nTPM (vital, limit 1); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 5); cerebral cortex: 16.4 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); rectum: 14.9 nTPM (protected, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (protected, limit 5); appendix: 14.1 nTPM (protected, limit 5); adrenal gland: 14 nTPM (vital, limit 1); gallbladder: 13.6 nTPM (protected, limit 5); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); parathyroid gland: 10.5 nTPM (protected, limit 5); esophagus: 10.5 nTPM (protected, limit 5); urinary bladder: 10.4 nTPM (protected, limit 5); pancreas: 10.4 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (protected, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000139304,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.9,3.9,"kidney: 6.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,PTPRQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 6.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139350,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,36.7,24.6,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 5); parathyroid gland: 14.4 nTPM (protected, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (protected, limit 5); esophagus: 9.7 nTPM (protected, limit 5); rectum: 9.4 nTPM (protected, limit 5); urinary bladder: 9.2 nTPM (protected, limit 5); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 5); retina: 7 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); duodenum: 6.9 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NEDD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 5); parathyroid gland: 14.4 nTPM (protected, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (protected, limit 5); esophagus: 9.7 nTPM (protected, limit 5); appendix: 9.4 nTPM (protected, limit 5); rectum: 9.4 nTPM (protected, limit 5); urinary bladder: 9.2 nTPM (protected, limit 5); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 5); gallbladder: 7.2 nTPM (protected, limit 5); stomach: 7 nTPM (protected, limit 5); retina: 7 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000139351,True,compatible,,True,0,1,partial,0.7,0.1,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; spleen; thymus,SYCP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000139445,True,compatible,,True,0,80,unavailable,0.8,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,FOXN4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000139496,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,25.4,22.5,"retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 5); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 5); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (protected, limit 5); urinary bladder: 17.9 nTPM (protected, limit 5); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (protected, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 5); esophagus: 12.4 nTPM (protected, limit 5); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 5); adrenal gland: 11.4 nTPM (vital, limit 2); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); pancreas: 10.5 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 5); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,NUP58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 5); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 5); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (protected, limit 5); urinary bladder: 17.9 nTPM (protected, limit 5); lung: 16.9 nTPM (vital, limit 1); appendix: 16.2 nTPM (protected, limit 5); cerebellum: 16.2 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (protected, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); gallbladder: 12.6 nTPM (protected, limit 5); esophagus: 12.4 nTPM (protected, limit 5); rectum: 12.4 nTPM (protected, limit 5); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 5); adrenal gland: 11.4 nTPM (vital, limit 2); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); pancreas: 10.5 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 5); choroid plexus: 4.2 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000139537,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,18.9,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139549,True,compatible,,True,0,80,unavailable,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,DHH,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,True,True,,,,unchanged
ENSG00000139618,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.4,2.1,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,BRCA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139714,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6,2.2,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MORN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139719,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.1,7.8,"retina: 10.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); cerebellum: 7.5 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); tongue: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); duodenum: 5 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,VPS33A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 10.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); cerebellum: 7.5 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); tongue: 5.8 nTPM (protected, limit 5); appendix: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); duodenum: 5 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139734,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7,2.3,"bone marrow: 7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DIAPH3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139797,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,RNF113B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000139800,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,27,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ZIC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139890,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.7,1.3,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,REM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000139915,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,4.3,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,44,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,MDGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140006,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,11,11,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 5); thyroid gland: 8.9 nTPM (protected, limit 5); kidney: 8.5 nTPM (vital, limit 1); liver: 8.5 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 5); tongue: 7 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); urinary bladder: 6.4 nTPM (protected, limit 5); colon: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,WDR89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 5); thyroid gland: 8.9 nTPM (protected, limit 5); kidney: 8.5 nTPM (vital, limit 1); liver: 8.5 nTPM (vital, limit 1); appendix: 7.4 nTPM (protected, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 5); tongue: 7 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); urinary bladder: 6.4 nTPM (protected, limit 5); colon: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 5); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000140009,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,5.9,2,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ESR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000140015,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,4.3,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,KCNH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000140025,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.6,7.9,"parathyroid gland: 7.9 nTPM (protected, limit 5); thyroid gland: 7.6 nTPM (protected, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EFCAB11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 7.9 nTPM (protected, limit 5); thyroid gland: 7.6 nTPM (protected, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140043,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,31.7,31.1,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 5); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (protected, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 5); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 5); adipose tissue: 6.7 nTPM (protected, limit 5); stomach: 6.1 nTPM (protected, limit 5); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PTGR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 5); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (protected, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 5); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 5); adipose tissue: 6.7 nTPM (protected, limit 5); stomach: 6.1 nTPM (protected, limit 5); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000140057,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,17.7,6.7,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,AK7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000140067,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,13.5,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 5); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,47,not_established,not_triggered,,,FAM181A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 5); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140090,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,44.8,1.1,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC24A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140199,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,30.1,18.3,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 5); kidney: 15.3 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 5); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 5); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (protected, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 5); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (protected, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SLC12A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 5); kidney: 15.3 nTPM (vital, limit 1); appendix: 11.2 nTPM (protected, limit 5); tongue: 10.5 nTPM (protected, limit 5); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 5); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (protected, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 5); cerebellum: 7.7 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 5); adipose tissue: 6.2 nTPM (protected, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); gallbladder: 5.1 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000140470,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.4,2,"liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ADAMTS17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140478,True,compatible,,True,0,1,partial,0.7,0,,,46,not_established,not_triggered,,,GOLGA6D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000140527,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.8,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,WDR93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140534,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.4,4.1,"bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TICRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140623,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,SEPTIN12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"cerebellum: 3.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140798,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ABCC12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140932,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,CMTM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140955,False,excluded,rna_above_tissue_ceiling,True,0,10,partial,2.1,0.7,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ADAD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000140993,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,9.5,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TIGD7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141096,True,compatible,,True,0,3,partial,1.7,0.6,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,DPEP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000141194,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,OR4D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000141200,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIF2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141219,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,22.9,20.7,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 5); thyroid gland: 15.4 nTPM (protected, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 5); cerebellum: 13 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 5); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 5); rectum: 9.7 nTPM (protected, limit 5); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 5); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 5); amygdala: 8.3 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (protected, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MTNAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 5); thyroid gland: 15.4 nTPM (protected, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 5); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 5); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 5); rectum: 9.7 nTPM (protected, limit 5); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); appendix: 9.2 nTPM (protected, limit 5); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 5); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); gallbladder: 8.4 nTPM (protected, limit 5); esophagus: 8.3 nTPM (protected, limit 5); amygdala: 8.3 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (protected, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141255,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,2.7,"midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,SPATA22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141316,False,excluded,rna_above_tissue_ceiling,True,0,6,partial,20.3,0.2,"pancreas: 20.3 nTPM (vital, limit 5); choroid plexus: 1.8 nTPM (vital, limit 1)",,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,SPACA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"pancreas: 20.3 nTPM (vital, limit 5); choroid plexus: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141371,True,compatible,,True,0,4,partial,0.6,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen; thymus,CHCT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000141384,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,2.8,3,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,TAF4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141404,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,61.7,12.8,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 5); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 5); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 5); tongue: 12.6 nTPM (protected, limit 5); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 5); colon: 6.9 nTPM (protected, limit 5); choroid plexus: 5 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GNAL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 5); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 5); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 5); tongue: 12.6 nTPM (protected, limit 5); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 5); colon: 6.9 nTPM (protected, limit 5); choroid plexus: 5 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000141425,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,12,partial,52.8,44.7,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 5); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (protected, limit 5); colon: 28.6 nTPM (protected, limit 5); heart muscle: 28.1 nTPM (vital, limit 1); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 5); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 5); esophagus: 22.8 nTPM (protected, limit 5); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 5); smooth muscle: 20.6 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 5); choroid plexus: 19.4 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 5); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); skeletal muscle / myocytes: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RPRD1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 5); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (protected, limit 5); colon: 28.6 nTPM (protected, limit 5); heart muscle: 28.1 nTPM (vital, limit 1); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 5); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 5); esophagus: 22.8 nTPM (protected, limit 5); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 5); smooth muscle: 20.6 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 5); choroid plexus: 19.4 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 5); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); gallbladder: 17.8 nTPM (protected, limit 5); appendix: 15.9 nTPM (protected, limit 5); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); appendix / endocrine cells: High (Supported); appendix / enterocytes: High (Supported); appendix / germinal center cells: Low (Supported); appendix / goblet cells: High (Supported); appendix / non-germinal center cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); skeletal muscle / myocytes: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141431,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ASXL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141437,True,compatible,,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,SLC25A52,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000141497,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.5,5.3,"parathyroid gland: 5.3 nTPM (protected, limit 5); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZMYND15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"parathyroid gland: 5.3 nTPM (protected, limit 5); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141505,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,1065.6,6.8,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 5); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ASGR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 5); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",gallbladder / glandular cells: Low (Enhanced); liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000141576,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,75,42,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 5); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); adipose tissue: 13.1 nTPM (protected, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 5); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RNF157,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 5); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); adipose tissue: 13.1 nTPM (protected, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 5); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141644,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,49.2,38.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); pituitary gland: 41.6 nTPM (vital, limit 1); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 5); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); colon: 34.5 nTPM (protected, limit 5); thyroid gland: 34.3 nTPM (protected, limit 5); cerebral cortex: 34.3 nTPM (vital, limit 1); urinary bladder: 34.2 nTPM (protected, limit 5); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 5); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 5); lymph node: 29.9 nTPM (protected, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 5); adipose tissue: 27.6 nTPM (protected, limit 5); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MBD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); pituitary gland: 41.6 nTPM (vital, limit 1); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 5); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 5); heart muscle: 34.5 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (protected, limit 5); cerebral cortex: 34.3 nTPM (vital, limit 1); urinary bladder: 34.2 nTPM (protected, limit 5); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 5); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 5); lymph node: 29.9 nTPM (protected, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 5); adipose tissue: 27.6 nTPM (protected, limit 5); basal ganglia: 26.1 nTPM (vital, limit 1); appendix: 25.6 nTPM (protected, limit 5); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); gallbladder: 19.2 nTPM (protected, limit 5); rectum: 17.4 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000141665,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,FBXO15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000141946,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ZIM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000141977,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.2,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,CIB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000142025,True,compatible,,True,0,3,partial,0.3,0.2,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,DMRTC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000142149,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,9.5,3.6,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HUNK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000142511,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,0,56.2,"parathyroid gland: 56.2 nTPM (protected, limit 5)",,0,not_established,not_triggered,,,GPR32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"parathyroid gland: 56.2 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000142513,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ACP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000142530,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,GARIN5A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000142538,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,1,0,,,0,not_established,not_triggered,,,PTH2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000142621,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,10.2,2.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FHAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000142684,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,97.7,37.9,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 5); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (protected, limit 5); esophagus: 31.6 nTPM (protected, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); thyroid gland: 27.2 nTPM (protected, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 5); hippocampal formation: 24.6 nTPM (vital, limit 1); colon: 22.9 nTPM (protected, limit 5); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 5); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 5); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 5); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF593,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 5); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (protected, limit 5); esophagus: 31.6 nTPM (protected, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); thyroid gland: 27.2 nTPM (protected, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 5); hippocampal formation: 24.6 nTPM (vital, limit 1); colon: 22.9 nTPM (protected, limit 5); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 5); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 5); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); appendix: 12.3 nTPM (protected, limit 5); lymph node: 9.8 nTPM (protected, limit 5); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); gallbladder: 5.9 nTPM (protected, limit 5); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000142698,True,compatible,,True,0,80,unavailable,0.7,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,C1orf94,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000142731,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,22.3,7.3,"bone marrow: 22.3 nTPM (vital, limit 1); lymph node: 7.3 nTPM (protected, limit 5); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PLK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 22.3 nTPM (vital, limit 1); lymph node: 7.3 nTPM (protected, limit 5); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000142920,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21.6,3.4,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AZIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000142945,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,32.6,16.1,"bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); colon: 6 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,KIF2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); appendix: 6.8 nTPM (protected, limit 5); colon: 6 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",appendix / endocrine cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000143006,True,compatible,,True,0,2,partial,0,0.1,,,48,not_established,not_triggered,,,DMRTB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000143032,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,43.9,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,BARHL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143105,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; thymus,KCNA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000143107,True,compatible,,True,0,4,partial,0.4,0,,,44,not_established,not_triggered,,,FNDC7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000143194,False,excluded,rna_above_tissue_ceiling,True,0,5,partial,5.4,1.2,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,42,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; thymus; tonsil,MAEL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143199,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,5.9,0.2,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,ADCY10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000143228,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,28,17.8,"bone marrow: 28 nTPM (vital, limit 1); lymph node: 17.8 nTPM (protected, limit 5); esophagus: 5.6 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NUF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 28 nTPM (vital, limit 1); lymph node: 17.8 nTPM (protected, limit 5); appendix: 6.7 nTPM (protected, limit 5); esophagus: 5.6 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143340,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,28.8,1.6,"pituitary gland: 28.8 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,FAM163A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 28.8 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143355,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,LHX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143443,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,9.9,7.9,"adrenal gland: 9.9 nTPM (vital, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 5); heart muscle: 7.7 nTPM (vital, limit 5); pancreas: 7.3 nTPM (vital, limit 5); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C1orf56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"adrenal gland: 9.9 nTPM (vital, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 5); heart muscle: 7.7 nTPM (vital, limit 5); pancreas: 7.3 nTPM (vital, limit 5); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 5); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000143450,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.8,4.1,"skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OAZ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143452,True,compatible,,True,0,3,partial,0.5,3.5,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,HORMAD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000143469,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,6,"thyroid gland: 6 nTPM (protected, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,SYT14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 6 nTPM (protected, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143476,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,14.4,5.4,"bone marrow: 14.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DTL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 14.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000143479,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.7,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); urinary bladder: 7.2 nTPM (protected, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DYRK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"gallbladder: 13 nTPM (protected, limit 5); bone marrow: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); urinary bladder: 7.2 nTPM (protected, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143494,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,3.9,"pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,VASH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000143498,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,3.9,6.3,"lymph node: 6.3 nTPM (protected, limit 5); urinary bladder: 5.1 nTPM (protected, limit 5); retina: 3.9 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TAF1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 6.3 nTPM (protected, limit 5); urinary bladder: 5.1 nTPM (protected, limit 5); retina: 3.9 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000143512,True,compatible,,True,0,2,partial,0.3,1.9,,,47,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,HHIPL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000143552,True,compatible,,True,0,2,partial,0.6,0.3,,,45,not_established,not_triggered,,,NUP210L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000143702,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,52,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (protected, limit 5); retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); heart muscle: 7.2 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 5); colon: 5.3 nTPM (protected, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,CEP170,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (protected, limit 5); retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); appendix: 8.2 nTPM (protected, limit 5); gallbladder: 7.8 nTPM (protected, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (protected, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 5); colon: 5.3 nTPM (protected, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000143751,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,32.4,16.9,"bone marrow: 32.4 nTPM (vital, limit 1); adipose tissue: 16.9 nTPM (protected, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (protected, limit 5); lymph node: 12.1 nTPM (protected, limit 5); urinary bladder: 11.2 nTPM (protected, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); tongue: 9.3 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 5); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 5); stomach: 7.5 nTPM (protected, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SDE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 32.4 nTPM (vital, limit 1); adipose tissue: 16.9 nTPM (protected, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 5); thyroid gland: 12.1 nTPM (protected, limit 5); urinary bladder: 11.2 nTPM (protected, limit 5); appendix: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 5); gallbladder: 10.2 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); tongue: 9.3 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 5); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 5); stomach: 7.5 nTPM (protected, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000143951,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,11.5,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,WDPCP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); appendix / glandular cells: Low (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000143994,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,3.2,1.6,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ABHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,False,False,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000144010,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,TRIM43B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000144015,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,TRIM43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000144061,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,37.1,16.4,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 5); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 5); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NPHP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 5); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 5); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000144130,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.8,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,NT5DC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144182,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,12.2,11,"bone marrow: 12.2 nTPM (vital, limit 2); thyroid gland: 11 nTPM (protected, limit 5); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); heart muscle: 8.2 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); duodenum: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 5); midbrain: 6.9 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (protected, limit 5); stomach: 6.7 nTPM (protected, limit 5); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); parathyroid gland: 6.1 nTPM (protected, limit 5); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,LIPT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 12.2 nTPM (vital, limit 2); thyroid gland: 11 nTPM (protected, limit 5); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); heart muscle: 8.2 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); duodenum: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 5); pancreas: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (protected, limit 5); stomach: 6.7 nTPM (protected, limit 5); appendix: 6.6 nTPM (protected, limit 5); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 5); gallbladder: 6.3 nTPM (protected, limit 5); parathyroid gland: 6.1 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000144395,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.2,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,CCDC150,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144401,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,23.1,16,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 5); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 5); adipose tissue: 9.8 nTPM (protected, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 5); colon: 8.9 nTPM (protected, limit 5); adrenal gland: 8.7 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 5); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 5); urinary bladder: 8.2 nTPM (protected, limit 5); lung: 8 nTPM (vital, limit 1); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,METTL21A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 5); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 5); appendix: 10.2 nTPM (protected, limit 5); adipose tissue: 9.8 nTPM (protected, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 5); colon: 8.9 nTPM (protected, limit 5); adrenal gland: 8.7 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 5); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 5); urinary bladder: 8.2 nTPM (protected, limit 5); lung: 8 nTPM (vital, limit 1); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); gallbladder: 6.6 nTPM (protected, limit 5); esophagus: 6.5 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000144445,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,21.9,192.4,"parathyroid gland: 192.4 nTPM (protected, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); tongue: 17.7 nTPM (protected, limit 5); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 5); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (protected, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); small intestine: 6.6 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); lymph node: 6.5 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KANSL1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 192.4 nTPM (protected, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); tongue: 17.7 nTPM (protected, limit 5); gallbladder: 15.2 nTPM (protected, limit 5); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 5); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (protected, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); rectum: 6.6 nTPM (protected, limit 5); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); appendix: 6 nTPM (protected, limit 5); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000144488,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.1,0.9,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ESPNL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144619,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,19.2,21.8,"parathyroid gland: 21.8 nTPM (protected, limit 5); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (protected, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CNTN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 21.8 nTPM (protected, limit 5); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (protected, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144671,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,0.2,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,SLC22A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144792,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF660,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000144821,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,3.1,2,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,MYH15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000144840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,15.6,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); tongue: 11.4 nTPM (protected, limit 5); parathyroid gland: 11.4 nTPM (protected, limit 5); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (protected, limit 5); cerebral cortex: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); esophagus: 7.7 nTPM (protected, limit 5); urinary bladder: 7.1 nTPM (protected, limit 5); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 5); pancreas: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RABL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (protected, limit 5); tongue: 11.4 nTPM (protected, limit 5); parathyroid gland: 11.4 nTPM (protected, limit 5); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (protected, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); esophagus: 7.7 nTPM (protected, limit 5); urinary bladder: 7.1 nTPM (protected, limit 5); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 5); pancreas: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); gallbladder: 5.5 nTPM (protected, limit 5); lung: 5.4 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000144893,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,3.8,1,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,MED12L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000144962,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,SPATA16,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000145040,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,3.3,"kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,UCN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000145216,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,27.8,18.9,"bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 5); adipose tissue: 18.4 nTPM (protected, limit 5); urinary bladder: 16.9 nTPM (protected, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 7.5); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 5); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (protected, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 5); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 5); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 5); amygdala: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FIP1L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 5); adipose tissue: 18.4 nTPM (protected, limit 5); urinary bladder: 16.9 nTPM (protected, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 7.5); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 5); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (protected, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 5); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 5); lung: 13.8 nTPM (vital, limit 1); appendix: 13.6 nTPM (protected, limit 5); stomach: 13.4 nTPM (protected, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 5); amygdala: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); gallbladder: 10.8 nTPM (protected, limit 5); midbrain: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000145309,True,compatible,,True,0,1,partial,0,0,,,47,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CABS1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000145331,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.5,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRMT10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (protected, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000145375,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,2.2,2.3,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AFG2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000145491,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,11,0.7,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 5); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ROPN1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Jamin 2021;Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 5); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000145743,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,42,30.5,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 5); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 5); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (protected, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (protected, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); smooth muscle: 8.5 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); rectum: 7.7 nTPM (protected, limit 5); colon: 7.6 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,FBXL17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 5); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 5); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (protected, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (protected, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); smooth muscle: 8.5 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); rectum: 7.7 nTPM (protected, limit 5); stomach: 7.7 nTPM (protected, limit 5); colon: 7.6 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); gallbladder: 6.7 nTPM (protected, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); appendix: 5.8 nTPM (protected, limit 5); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000145757,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,0.3,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,SPATA9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,appendix / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000145850,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,15.8,53.9,"lymph node: 53.9 nTPM (protected, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (protected, limit 5); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,TIMD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lymph node: 53.9 nTPM (protected, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (protected, limit 5); appendix: 6.7 nTPM (protected, limit 5); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000145868,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,18,17.9,"skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 5); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 5); lymph node: 14.2 nTPM (protected, limit 5); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 5); rectum: 12.6 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (protected, limit 5); stomach: 12.1 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); thyroid gland: 11.9 nTPM (protected, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); small intestine: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 5); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,FBXO38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 5); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 5); lymph node: 14.2 nTPM (protected, limit 5); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 5); rectum: 12.6 nTPM (protected, limit 5); appendix: 12.5 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); stomach: 12.1 nTPM (protected, limit 5); thyroid gland: 11.9 nTPM (protected, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); small intestine: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); gallbladder: 11.1 nTPM (protected, limit 5); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 5); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000145975,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,FAM217A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000145979,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,30.5,16.7,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 5); rectum: 15.9 nTPM (protected, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 5); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); lymph node: 13.6 nTPM (protected, limit 5); hippocampal formation: 13.6 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 5); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 5); stomach: 9.5 nTPM (protected, limit 5); choroid plexus: 9.3 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (protected, limit 5); thyroid gland: 7.8 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,TBC1D7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 5); rectum: 15.9 nTPM (protected, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 5); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 5); lymph node: 13.6 nTPM (protected, limit 5); hippocampal formation: 13.6 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 5); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); gallbladder: 10 nTPM (protected, limit 5); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 5); stomach: 9.5 nTPM (protected, limit 5); appendix: 9.4 nTPM (protected, limit 5); choroid plexus: 9.3 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (protected, limit 5); thyroid gland: 7.8 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000146047,True,compatible,family_exclusion,True,0,2,partial,0.1,0,,,47,not_established,not_triggered,,,H2BC1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,False,True,,,family_exclusion,unchanged
ENSG00000146221,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.6,0.2,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; thymus,TCTE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000146243,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.4,3.5,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IRAK1BP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000146263,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7,3.4,"bone marrow: 7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MMS22L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000146276,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,23.9,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,GABRR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"retina: 23.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000146378,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TAAR2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000146410,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,16.1,6.2,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MTFR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000146453,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,3.6,0.4,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,PNLDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000146670,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,52.7,16.6,"bone marrow: 52.7 nTPM (vital, limit 1); lymph node: 16.6 nTPM (protected, limit 5); esophagus: 9.1 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); colon: 6.6 nTPM (protected, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CDCA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 52.7 nTPM (vital, limit 1); lymph node: 16.6 nTPM (protected, limit 5); appendix: 10.2 nTPM (protected, limit 5); esophagus: 9.1 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); colon: 6.6 nTPM (protected, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / endocrine cells: High (Enhanced); appendix / enterocytes: Medium (Enhanced); appendix / goblet cells: Medium (Enhanced); appendix / non-germinal center cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000146733,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,13,8.5,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); heart muscle: 7.9 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 5); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 5); stomach: 6 nTPM (protected, limit 5); lymph node: 5.1 nTPM (protected, limit 5); smooth muscle: 4.9 nTPM (vital, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,PSPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); liver: 6.6 nTPM (vital, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 5); stomach: 6 nTPM (protected, limit 5); gallbladder: 5.8 nTPM (protected, limit 5); lymph node: 5.1 nTPM (protected, limit 5); smooth muscle: 4.9 nTPM (vital, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000146839,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZAN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000146859,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,84.5,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (protected, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 5); lymph node: 19.7 nTPM (protected, limit 5); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 5); urinary bladder: 16 nTPM (protected, limit 5); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 5); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); rectum: 8.1 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TMEM140,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (protected, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 5); lymph node: 19.7 nTPM (protected, limit 5); appendix: 19 nTPM (protected, limit 5); adrenal gland: 18.6 nTPM (vital, limit 1); gallbladder: 18.6 nTPM (protected, limit 5); duodenum: 17.3 nTPM (vital, limit 1); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 5); urinary bladder: 16 nTPM (protected, limit 5); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 5); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); rectum: 8.1 nTPM (protected, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000146918,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,24.1,12.1,"bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); esophagus: 6.7 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NCAPG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 5); appendix: 8.6 nTPM (protected, limit 5); rectum: 7.4 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); esophagus: 6.7 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000147081,True,compatible,,True,0,2,partial,0,0,,,46,not_established,not_triggered,,,AKAP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000147082,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.4,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCNB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,False,False,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000147127,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,56,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,RAB41,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000147180,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,18.3,4.8,"cerebral cortex: 18.3 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 5); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ZNF711,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 18.3 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 5); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000147183,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CPXCR1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000147206,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,2,partial,4.8,0.9,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,NXF3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"gallbladder: 7.2 nTPM (protected, limit 5); lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000147316,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,13.1,5.5,"bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); lymph node: 5.2 nTPM (protected, limit 5); urinary bladder: 5.2 nTPM (protected, limit 5); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MCPH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); lymph node: 5.2 nTPM (protected, limit 5); urinary bladder: 5.2 nTPM (protected, limit 5); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000147378,True,compatible,,True,0,2,partial,0.9,0.6,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FATE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000147381,True,compatible,,True,0,2,partial,0.1,0.6,,,48,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,MAGEA4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000147536,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,5.7,5,"bone marrow: 5.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GINS4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000147570,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.9,7.5,"lymph node: 7.5 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,DNAJC5B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025,False,False,"lymph node: 7.5 nTPM (protected, limit 5); lung: 5.9 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000147571,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,46,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CRH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000147596,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,PRDM14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000147613,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,2.4,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),44,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,PSKH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000147874,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,16.8,11.1,"bone marrow: 16.8 nTPM (vital, limit 1); lymph node: 11.1 nTPM (protected, limit 5); retina: 8.7 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 5); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); parathyroid gland: 5.9 nTPM (protected, limit 5); urinary bladder: 5.9 nTPM (protected, limit 5); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); adipose tissue: 5.1 nTPM (protected, limit 5); heart muscle: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HAUS6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 16.8 nTPM (vital, limit 1); lymph node: 11.1 nTPM (protected, limit 5); retina: 8.7 nTPM (vital, limit 1); appendix: 7.7 nTPM (protected, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 5); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); parathyroid gland: 5.9 nTPM (protected, limit 5); urinary bladder: 5.9 nTPM (protected, limit 5); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); small intestine: 5.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (protected, limit 5); heart muscle: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000147912,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,28.7,13.4,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); adrenal gland: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FBXO10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); adrenal gland: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000148019,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,12.2,6,"bone marrow: 12.2 nTPM (vital, limit 1); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); spinal cord: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); small intestine: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CEP78,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 12.2 nTPM (vital, limit 1); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); spinal cord: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); small intestine: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000148156,True,compatible,,True,0,5,partial,0,0,,,45,not_established,not_triggered,,,ACTL7B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000148200,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.3,5.2,"thyroid gland: 5.2 nTPM (protected, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NR6A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"thyroid gland: 5.2 nTPM (protected, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000148215,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000148602,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,24.9,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,LRIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"retina: 24.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000148604,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,134.8,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,RGR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000148680,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,2,12.7,"parathyroid gland: 12.7 nTPM (protected, limit 5); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,HTR7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"parathyroid gland: 12.7 nTPM (protected, limit 5); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000148814,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,15.3,7.7,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 5); kidney: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRRC27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 5); kidney: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000148832,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.5,6.1,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 5); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PAOX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 5); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000148848,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,3.1,8.6,"basal ganglia: 2 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ADAM12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,False,False,"basal ganglia: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000148950,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,48.3,41,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 5); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 5); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 5); thyroid gland: 12.8 nTPM (protected, limit 5); colon: 12.3 nTPM (protected, limit 5); esophagus: 11.4 nTPM (protected, limit 5); adipose tissue: 11.3 nTPM (protected, limit 5); bone marrow: 11 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 5); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 5); lymph node: 9.3 nTPM (protected, limit 5); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,IMMP1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 5); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 5); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 5); thyroid gland: 12.8 nTPM (protected, limit 5); colon: 12.3 nTPM (protected, limit 5); esophagus: 11.4 nTPM (protected, limit 5); adipose tissue: 11.3 nTPM (protected, limit 5); bone marrow: 11 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 5); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 5); lymph node: 9.3 nTPM (protected, limit 5); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1); appendix: 6.2 nTPM (protected, limit 5)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000149050,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.2,3.3,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF214,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149054,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,2.2,3.3,"pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZNF215,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000149212,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,30.7,25,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 5); lymph node: 23.8 nTPM (protected, limit 5); retina: 22.7 nTPM (vital, limit 1); thyroid gland: 21.1 nTPM (protected, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); kidney: 10.1 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 5); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 5); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SESN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 5); lymph node: 23.8 nTPM (protected, limit 5); retina: 22.7 nTPM (vital, limit 1); thyroid gland: 21.1 nTPM (protected, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); midbrain: 14.2 nTPM (vital, limit 1); appendix: 13.9 nTPM (protected, limit 5); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 5); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); gallbladder: 12 nTPM (protected, limit 5); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); kidney: 10.1 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 5); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 5); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 5); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149243,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,10.4,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; thymus,KLHL35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149346,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,5.2,3.2,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,SLX4IP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000149507,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,OOSP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000149548,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,1.2,"bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149554,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,26,14.7,"bone marrow: 26 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 5); parathyroid gland: 12.8 nTPM (protected, limit 5); rectum: 8.6 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CHEK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 26 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 5); parathyroid gland: 12.8 nTPM (protected, limit 5); rectum: 8.6 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); appendix: 7.9 nTPM (protected, limit 5); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149609,True,compatible,,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,C20orf144,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000149646,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,22.9,16.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CNBD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000149651,False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,2,partial,1,0,,adrenal gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,SPINT4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,adrenal gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000149679,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13.8,5,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CABLES2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149926,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,85.2,1.6,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,TLCD3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000149948,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,4.8,2.3,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HMGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000150244,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TRIM48,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000150275,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,59.9,0.5,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDH15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000150455,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.9,6.6,"small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); thyroid gland: 5.1 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TIRAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); thyroid gland: 5.1 nTPM (protected, limit 5); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000150477,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,20.5,5.3,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KIAA1328,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000150527,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,131,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); thyroid gland: 45.2 nTPM (protected, limit 5); stomach: 43.6 nTPM (protected, limit 5); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 5); rectum: 33.4 nTPM (protected, limit 5); colon: 29.6 nTPM (protected, limit 5); esophagus: 26.2 nTPM (protected, limit 5); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 5); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 5); urinary bladder: 15.6 nTPM (protected, limit 5); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (protected, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,MIA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); thyroid gland: 45.2 nTPM (protected, limit 5); stomach: 43.6 nTPM (protected, limit 5); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 5); rectum: 33.4 nTPM (protected, limit 5); colon: 29.6 nTPM (protected, limit 5); gallbladder: 28.8 nTPM (protected, limit 5); esophagus: 26.2 nTPM (protected, limit 5); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 5); appendix: 16.3 nTPM (protected, limit 5); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 5); urinary bladder: 15.6 nTPM (protected, limit 5); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (protected, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000150628,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,2.2,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,46,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,SPATA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000150667,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,10.6,"rectum: 10.6 nTPM (protected, limit 5); colon: 7.1 nTPM (protected, limit 5); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FSIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"rectum: 10.6 nTPM (protected, limit 5); colon: 7.1 nTPM (protected, limit 5); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000150676,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CCDC83,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000150760,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,35.5,25.8,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (protected, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 5); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (protected, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); colon: 17.1 nTPM (protected, limit 5); urinary bladder: 15.9 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DOCK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (protected, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 5); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (protected, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); colon: 17.1 nTPM (protected, limit 5); gallbladder: 16.6 nTPM (protected, limit 5); urinary bladder: 15.9 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 2); appendix: 7.1 nTPM (protected, limit 5); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000150773,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PIH1D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000150776,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,32.4,15.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thyroid gland: 15.5 nTPM (protected, limit 5); kidney: 14.1 nTPM (vital, limit 1); cerebral cortex: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 5); adipose tissue: 13.7 nTPM (protected, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 5); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 5); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11.9 nTPM (vital, limit 1); pancreas: 11.9 nTPM (vital, limit 1); colon: 11.8 nTPM (protected, limit 5); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 5); stomach: 11.2 nTPM (protected, limit 5); urinary bladder: 11.1 nTPM (protected, limit 5); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 5); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NKAPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thyroid gland: 15.5 nTPM (protected, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 5); adipose tissue: 13.7 nTPM (protected, limit 5); parathyroid gland: 13.6 nTPM (protected, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 5); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); colon: 11.8 nTPM (protected, limit 5); liver: 11.4 nTPM (vital, limit 1); gallbladder: 11.4 nTPM (protected, limit 5); rectum: 11.3 nTPM (protected, limit 5); appendix: 11.3 nTPM (protected, limit 5); stomach: 11.2 nTPM (protected, limit 5); urinary bladder: 11.1 nTPM (protected, limit 5); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 5); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000150783,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,8.4,0.7,"retina: 8.4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TEX12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 8.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000151005,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,TKTL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000151033,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,LYZL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000151062,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,19.5,0.4,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,CACNA2D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 19.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000151164,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0.8,0.5,,skeletal muscle / myocytes: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RAD9B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,,skeletal muscle / myocytes: Medium (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000151247,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,56.6,52.4,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 5); retina: 52.4 nTPM (vital, limit 1); thyroid gland: 51 nTPM (protected, limit 5); rectum: 50.6 nTPM (protected, limit 5); esophagus: 50 nTPM (protected, limit 5); tongue: 46.3 nTPM (protected, limit 5); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 5); lymph node: 43.6 nTPM (protected, limit 5); parathyroid gland: 43.5 nTPM (protected, limit 5); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (protected, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 5); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,EIF4E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 5); retina: 52.4 nTPM (vital, limit 1); thyroid gland: 51 nTPM (protected, limit 5); rectum: 50.6 nTPM (protected, limit 5); esophagus: 50 nTPM (protected, limit 5); tongue: 46.3 nTPM (protected, limit 5); kidney: 45.7 nTPM (vital, limit 1); lymph node: 43.6 nTPM (protected, limit 5); colon: 43.6 nTPM (protected, limit 5); parathyroid gland: 43.5 nTPM (protected, limit 5); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); appendix: 36.7 nTPM (protected, limit 5); adipose tissue: 36.6 nTPM (protected, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 5); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); gallbladder: 30.3 nTPM (protected, limit 5); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000151287,False,excluded,rna_above_tissue_ceiling,True,0,8,partial,38.8,11.6,"liver: 38.8 nTPM (vital, limit 5); kidney: 18.5 nTPM (vital, limit 5); bone marrow: 14.2 nTPM (vital, limit 5); lymph node: 11.6 nTPM (protected, limit 5); cerebellum: 10.8 nTPM (vital, limit 5); cerebral cortex: 9.9 nTPM (vital, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 5); tongue: 9 nTPM (protected, limit 5); heart muscle: 8.8 nTPM (vital, limit 5); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 5); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 5); lung: 5.7 nTPM (vital, limit 5); pancreas: 5.5 nTPM (vital, limit 5); duodenum: 5.3 nTPM (vital, limit 5); small intestine: 5.2 nTPM (vital, limit 5)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,TEX30,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 38.8 nTPM (vital, limit 5); kidney: 18.5 nTPM (vital, limit 5); bone marrow: 14.2 nTPM (vital, limit 5); lymph node: 11.6 nTPM (protected, limit 5); cerebellum: 10.8 nTPM (vital, limit 5); cerebral cortex: 9.9 nTPM (vital, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 5); tongue: 9 nTPM (protected, limit 5); heart muscle: 8.8 nTPM (vital, limit 5); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 5); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 5); lung: 5.7 nTPM (vital, limit 5); pancreas: 5.5 nTPM (vital, limit 5); duodenum: 5.3 nTPM (vital, limit 5); small intestine: 5.2 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000151338,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,4.2,6.7,"parathyroid gland: 6.7 nTPM (protected, limit 5); thyroid gland: 5.6 nTPM (protected, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MIPOL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"parathyroid gland: 6.7 nTPM (protected, limit 5); thyroid gland: 5.6 nTPM (protected, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000151360,True,compatible,,True,0,80,unavailable,0.6,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; thymus,ALLC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000151475,False,excluded,positive_ihc_outside_permitted,True,0,0,routine_complete,0.1,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),47,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,SLC25A31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),positive_ihc_outside_permitted,unchanged
ENSG00000151575,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 5); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TEX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 5); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 5); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000151577,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,3.2,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,DRD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"basal ganglia: 3.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000151615,True,compatible,,True,0,80,unavailable,1,0,,,0,not_established,not_triggered,,,POU4F2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000151687,True,compatible,,True,0,80,unavailable,0.6,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANKAR,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000151725,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,61.8,15.8,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 5); esophagus: 10.1 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); colon: 7.5 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CENPU,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 5); esophagus: 10.1 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); colon: 7.5 nTPM (protected, limit 5); appendix: 5.2 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000151773,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,4.5,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CCDC122,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000151789,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.9,3.5,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF385D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000151846,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,0.4,0.8,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PABPC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,False,False,,appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000151962,True,compatible,,True,0,80,unavailable,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; thymus,RBM46,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000152086,False,excluded,rna_above_tissue_ceiling;family_exclusion,True,0,80,unavailable,51.5,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,TUBA3E,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"heart muscle: 51.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;family_exclusion,unchanged
ENSG00000152102,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,69.2,52.4,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 10); tongue: 50.9 nTPM (protected, limit 5); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 5); bone marrow: 45.7 nTPM (vital, limit 5); parathyroid gland: 45.2 nTPM (protected, limit 10); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (protected, limit 10); smooth muscle: 39.4 nTPM (vital, limit 5); kidney: 37.1 nTPM (vital, limit 5); stomach: 35.2 nTPM (protected, limit 5); thyroid gland: 35.1 nTPM (protected, limit 5); small intestine: 33.4 nTPM (vital, limit 5); esophagus: 33.3 nTPM (protected, limit 10); adrenal gland: 32.6 nTPM (vital, limit 5); rectum: 30.9 nTPM (protected, limit 10); liver: 30.1 nTPM (vital, limit 5); pancreas: 29.2 nTPM (vital, limit 5); lymph node: 27.1 nTPM (protected, limit 5); lung: 26.7 nTPM (vital, limit 5); duodenum: 25.6 nTPM (vital, limit 5); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM168B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 10); tongue: 50.9 nTPM (protected, limit 5); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 5); bone marrow: 45.7 nTPM (vital, limit 5); parathyroid gland: 45.2 nTPM (protected, limit 10); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (protected, limit 10); smooth muscle: 39.4 nTPM (vital, limit 5); kidney: 37.1 nTPM (vital, limit 5); stomach: 35.2 nTPM (protected, limit 5); thyroid gland: 35.1 nTPM (protected, limit 5); small intestine: 33.4 nTPM (vital, limit 5); esophagus: 33.3 nTPM (protected, limit 10); adrenal gland: 32.6 nTPM (vital, limit 5); rectum: 30.9 nTPM (protected, limit 10); liver: 30.1 nTPM (vital, limit 5); pancreas: 29.2 nTPM (vital, limit 5); lymph node: 27.1 nTPM (protected, limit 5); lung: 26.7 nTPM (vital, limit 5); appendix: 26.1 nTPM (protected, limit 10); duodenum: 25.6 nTPM (vital, limit 5); gallbladder: 22.9 nTPM (protected, limit 10); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152192,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,2.5,0.5,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; thymus; tonsil,POU4F1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152208,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,11.2,0.1,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),63,not_established,not_triggered,,,GRID2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152253,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.9,4.3,"bone marrow: 3.9 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SPC25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.9 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152315,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,4.3,5.8,"parathyroid gland: 5.8 nTPM (protected, limit 5); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KCNK13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 5.8 nTPM (protected, limit 5); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152348,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,6.9,11.2,"parathyroid gland: 11.2 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); kidney: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ATG10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"parathyroid gland: 11.2 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 5); kidney: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000152409,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,11.4,11.1,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); colon: 10.5 nTPM (protected, limit 5); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (protected, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 5); smooth muscle: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,JMY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); colon: 10.5 nTPM (protected, limit 5); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (protected, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 5); smooth muscle: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000152422,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,7.7,8.3,"lymph node: 8.3 nTPM (protected, limit 5); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 5); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); amygdala: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,XRCC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 8.3 nTPM (protected, limit 5); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); appendix: 5.8 nTPM (protected, limit 5); colon: 5.7 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 5); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); amygdala: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000152430,True,compatible,,True,0,1,partial,3.6,1.3,,,47,not_established,not_triggered,,,BOLL,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000152443,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,20,10.5,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); parathyroid gland: 10.5 nTPM (protected, limit 5); tongue: 9.9 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 5); pituitary gland: 8 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 5); kidney: 7.4 nTPM (vital, limit 1); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); midbrain: 5.1 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF776,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); parathyroid gland: 10.5 nTPM (protected, limit 5); tongue: 9.9 nTPM (protected, limit 5); thyroid gland: 9 nTPM (protected, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 5); pituitary gland: 8 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 5); kidney: 7.4 nTPM (vital, limit 1); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); midbrain: 5.1 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000152455,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.9,3.3,"retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SUV39H2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000152463,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,1.7,2.9,,adrenal gland / glandular cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,OLAH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,adrenal gland / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000152464,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,21.5,19.6,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 5); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); urinary bladder: 17 nTPM (protected, limit 5); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 5); small intestine: 16.1 nTPM (vital, limit 1); esophagus: 15.8 nTPM (protected, limit 5); colon: 15.8 nTPM (protected, limit 5); thyroid gland: 15.7 nTPM (protected, limit 5); duodenum: 15.4 nTPM (vital, limit 1); stomach: 15 nTPM (protected, limit 5); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 5); parathyroid gland: 13.8 nTPM (protected, limit 5); adipose tissue: 13.5 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RPP38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 5); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); choroid plexus: 17 nTPM (vital, limit 1); urinary bladder: 17 nTPM (protected, limit 5); kidney: 16.7 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 5); small intestine: 16.1 nTPM (vital, limit 1); colon: 15.8 nTPM (protected, limit 5); esophagus: 15.8 nTPM (protected, limit 5); thyroid gland: 15.7 nTPM (protected, limit 5); duodenum: 15.4 nTPM (vital, limit 1); stomach: 15 nTPM (protected, limit 5); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 5); parathyroid gland: 13.8 nTPM (protected, limit 5); adipose tissue: 13.5 nTPM (protected, limit 5); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); appendix: 12 nTPM (protected, limit 5); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); gallbladder: 10.8 nTPM (protected, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152495,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,53.5,7.9,"cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,CAMK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152503,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,42.9,7.3,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); basal ganglia: 4.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRIM36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); basal ganglia: 4.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000152582,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,18.5,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 5); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152592,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,0,0.1,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DMP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000152611,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,88.5,5.2,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); hippocampal formation: 7.1 nTPM (vital, limit 1); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,CAPSL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); hippocampal formation: 7.1 nTPM (vital, limit 1); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000152670,True,compatible,,True,0,1,partial,0.4,0.2,,,48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; thymus; tonsil,DDX4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000152705,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,1.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CATSPER3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000152763,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,20,6.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 5); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); lung: 4.1 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAI4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 5); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); lung: 4.1 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153044,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,33.2,17.3,"bone marrow: 33.2 nTPM (vital, limit 2); lymph node: 17.3 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); esophagus: 7.3 nTPM (protected, limit 5); colon: 7.1 nTPM (protected, limit 5); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,CENPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 33.2 nTPM (vital, limit 2); lymph node: 17.3 nTPM (protected, limit 5); rectum: 7.8 nTPM (protected, limit 5); esophagus: 7.3 nTPM (protected, limit 5); appendix: 7.3 nTPM (protected, limit 5); colon: 7.1 nTPM (protected, limit 5); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000153060,True,compatible,,True,0,80,unavailable,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,TEKT5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000153093,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.9,4.5,"lung: 8.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACOXL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 8.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153132,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,57.4,2.6,"heart muscle: 57.4 nTPM (vital, limit 5); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 5); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 57.4 nTPM (vital, limit 5); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 5); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153157,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,66.4,"parathyroid gland: 66.4 nTPM (protected, limit 5); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCP2L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 66.4 nTPM (protected, limit 5); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153165,True,compatible,,True,0,80,unavailable,0.9,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RGPD3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000153207,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,16.7,15.1,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 5); thyroid gland: 13.3 nTPM (protected, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 5); adipose tissue: 12.2 nTPM (protected, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 5); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); lymph node: 8.9 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); stomach: 8.3 nTPM (protected, limit 5); cerebellum: 8.2 nTPM (vital, limit 1); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AHCTF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 5); thyroid gland: 13.3 nTPM (protected, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 5); adipose tissue: 12.2 nTPM (protected, limit 5); skeletal muscle: 10.6 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 5); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 5); lymph node: 8.9 nTPM (protected, limit 5); colon: 8.8 nTPM (protected, limit 5); stomach: 8.3 nTPM (protected, limit 5); cerebellum: 8.2 nTPM (vital, limit 1); appendix: 8.2 nTPM (protected, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); gallbladder: 7.2 nTPM (protected, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000153237,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,3.1,"kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,CCDC148,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153347,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,60.6,2.4,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,46,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,FAM81B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153495,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12,0.5,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,TEX29,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153498,True,compatible,,True,0,3,partial,0.5,0.2,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SPACA7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000153684,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GOLGA8F,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000153721,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,18.3,12.8,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 2); colon: 6.3 nTPM (protected, limit 5); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CNKSR3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 2); colon: 6.3 nTPM (protected, limit 5); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000153779,True,compatible,,True,0,6,partial,0,0,,,43,not_established,not_triggered,,,TGIF2LX,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000153790,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.6,6.6,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPMIP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153898,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.5,14.6,"rectum: 14.6 nTPM (protected, limit 5); lymph node: 12.5 nTPM (protected, limit 5); colon: 9.8 nTPM (protected, limit 5); adrenal gland: 8.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MCOLN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"rectum: 14.6 nTPM (protected, limit 5); lymph node: 12.5 nTPM (protected, limit 5); colon: 9.8 nTPM (protected, limit 5); adrenal gland: 8.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000153982,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.6,5.7,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 5); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GDPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 5); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000154007,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,ASB17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000154040,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,12.7,2.3,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 5); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CABYR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 5); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000154059,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,23.5,31.5,"thyroid gland: 31.5 nTPM (protected, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 5); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 5); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (protected, limit 5); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 5); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); rectum: 14.4 nTPM (protected, limit 5); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 5); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 5); retina: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,IMPACT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 31.5 nTPM (protected, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 5); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 5); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (protected, limit 5); heart muscle: 18.6 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); hypothalamus: 17.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 5); lung: 15.2 nTPM (vital, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); rectum: 14.4 nTPM (protected, limit 5); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 5); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); gallbladder: 12.2 nTPM (protected, limit 5); amygdala: 11.8 nTPM (vital, limit 1); appendix: 11.7 nTPM (protected, limit 5); lymph node: 11.2 nTPM (protected, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154099,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,23.7,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,DNAAF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000154114,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,14.4,14.9,"parathyroid gland: 14.9 nTPM (protected, limit 5); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (protected, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 5); lymph node: 7 nTPM (protected, limit 5); adipose tissue: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 5); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 5); esophagus: 5.5 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); small intestine: 5.5 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TBCEL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 14.9 nTPM (protected, limit 5); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (protected, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); gallbladder: 7.1 nTPM (protected, limit 5); colon: 7 nTPM (protected, limit 5); lymph node: 7 nTPM (protected, limit 5); adipose tissue: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 5); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 5); appendix: 5.5 nTPM (protected, limit 5); small intestine: 5.5 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); esophagus: 5.5 nTPM (protected, limit 5); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154143,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,PANX3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000154227,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,0.6,53.6,"esophagus: 53.6 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CERS3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"esophagus: 53.6 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000154438,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,ASZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000154479,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,45.9,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,CFAP210,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000154548,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,4.2,1.5,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SRSF12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000154611,True,compatible,,True,0,80,unavailable,0.1,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,PSMA8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000154645,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,7.9,3.4,"hypothalamus: 7.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CHODL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hypothalamus: 7.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000154655,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,8.5,8.2,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (protected, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,L3MBTL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (protected, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154710,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,76,19.2,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); esophagus: 19.2 nTPM (protected, limit 5); urinary bladder: 18.5 nTPM (protected, limit 5); adipose tissue: 15.7 nTPM (protected, limit 5); thyroid gland: 15.6 nTPM (protected, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 5); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 5); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 5); lymph node: 11.4 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 5); stomach: 10.3 nTPM (protected, limit 5); lung: 10.3 nTPM (vital, limit 1); heart muscle: 9.6 nTPM (vital, limit 1); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); duodenum: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RABGEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); esophagus: 19.2 nTPM (protected, limit 5); urinary bladder: 18.5 nTPM (protected, limit 5); adipose tissue: 15.7 nTPM (protected, limit 5); thyroid gland: 15.6 nTPM (protected, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 5); gallbladder: 14 nTPM (protected, limit 5); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 5); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 5); lymph node: 11.4 nTPM (protected, limit 5); kidney: 11.2 nTPM (vital, limit 1); appendix: 11.1 nTPM (protected, limit 5); colon: 10.5 nTPM (protected, limit 5); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 5); heart muscle: 9.6 nTPM (vital, limit 1); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); duodenum: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000154727,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,18.7,20.6,"thyroid gland: 20.6 nTPM (protected, limit 5); lymph node: 19.9 nTPM (protected, limit 5); liver: 18.7 nTPM (vital, limit 3); adipose tissue: 16.4 nTPM (protected, limit 5); tongue: 15.9 nTPM (protected, limit 5); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 5); adrenal gland: 13.4 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 5); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 5); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 5); stomach: 11.5 nTPM (protected, limit 5); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 5); skeletal muscle: 10.2 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GABPA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 20.6 nTPM (protected, limit 5); lymph node: 19.9 nTPM (protected, limit 5); liver: 18.7 nTPM (vital, limit 3); adipose tissue: 16.4 nTPM (protected, limit 5); tongue: 15.9 nTPM (protected, limit 5); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 5); appendix: 13.7 nTPM (protected, limit 5); adrenal gland: 13.4 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 5); small intestine: 13 nTPM (vital, limit 1); gallbladder: 12.9 nTPM (protected, limit 5); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 5); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 5); stomach: 11.5 nTPM (protected, limit 5); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 5); skeletal muscle: 10.2 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154764,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4,0.4,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,WNT7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000154839,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,11.8,4.7,"bone marrow: 11.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SKA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154920,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,4.3,2.2,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,EME1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154928,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,20.2,9.9,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 5); tongue: 9.9 nTPM (protected, limit 5); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,EPHB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 5); tongue: 9.9 nTPM (protected, limit 5); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000154997,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,2.3,1.2,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SEPTIN14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155026,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,4.2,0.9,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,RSPH10B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000155085,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,15.5,8.8,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 5); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,AK9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 5); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000155087,True,compatible,,True,0,1,partial,0.7,0.1,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ODF1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000155249,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4K1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000155313,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,116.3,72.7,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 5); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); adipose tissue: 24.6 nTPM (protected, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 5); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 5); liver: 19.4 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 5); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (protected, limit 5); urinary bladder: 14.9 nTPM (protected, limit 5); colon: 14.8 nTPM (protected, limit 5); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 5); hippocampal formation: 13 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,USP25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 5); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); adipose tissue: 24.6 nTPM (protected, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 5); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 5); liver: 19.4 nTPM (vital, limit 1); appendix: 16.3 nTPM (protected, limit 5); rectum: 15.6 nTPM (protected, limit 5); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (protected, limit 5); urinary bladder: 14.9 nTPM (protected, limit 5); colon: 14.8 nTPM (protected, limit 5); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 5); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); gallbladder: 12 nTPM (protected, limit 5); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000155330,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,13.2,7.2,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 5); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 5); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,C16orf87,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 5); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 5); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000155367,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,73.1,27.1,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,PPM1J,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000155495,True,compatible,,True,0,1,partial,0,0,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,MAGEC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000155530,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRGUK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155592,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,4.4,"retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZKSCAN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155621,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,11.2,9.6,"duodenum: 11.2 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 5); urinary bladder: 9.3 nTPM (protected, limit 5); lymph node: 8.3 nTPM (protected, limit 5); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (protected, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 5); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 5); hippocampal formation: 7.3 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); rectum: 7.2 nTPM (protected, limit 5); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); heart muscle: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C9orf85,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 11.2 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 5); urinary bladder: 9.3 nTPM (protected, limit 5); skeletal muscle: 8.3 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 5); thyroid gland: 8.2 nTPM (protected, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 5); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 5); hippocampal formation: 7.3 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); rectum: 7.2 nTPM (protected, limit 5); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); gallbladder: 6.5 nTPM (protected, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); appendix: 6.2 nTPM (protected, limit 5); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000155622,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,3,unreliable,5.5,0.1,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),43,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,XAGE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000155714,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,PDZD9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"cerebellum: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155719,True,compatible,,True,0,1,partial,0.4,0.2,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,OTOA,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000155749,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.7,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FLACC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155754,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,C2CD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,False,False,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000155833,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CYLC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000155875,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; thymus,SAXO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000155890,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000156009,True,compatible,,True,0,3,partial,0.2,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,MAGEA8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000156042,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,58.6,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP70,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000156172,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,4.9,3.3,"retina: 4.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CFAP418,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000156194,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,231.4,0,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,PPEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 231.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000156269,True,compatible,,True,0,2,partial,0.4,0.1,,,46,not_established,not_triggered,,,NAA11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000156273,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,88.2,28.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 5); skeletal muscle: 25.4 nTPM (vital, limit 2); esophagus: 22.2 nTPM (protected, limit 5); lung: 20.7 nTPM (vital, limit 2); small intestine: 16.9 nTPM (vital, limit 1); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 5); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); kidney: 15.3 nTPM (vital, limit 2); adipose tissue: 15.3 nTPM (protected, limit 5); stomach: 13.1 nTPM (protected, limit 5); colon: 12.9 nTPM (protected, limit 5); rectum: 12.7 nTPM (protected, limit 5); heart muscle: 12.7 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); thyroid gland: 12.2 nTPM (protected, limit 5); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 5); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BACH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 5); appendix: 26.9 nTPM (protected, limit 5); skeletal muscle: 25.4 nTPM (vital, limit 2); gallbladder: 25.1 nTPM (protected, limit 5); esophagus: 22.2 nTPM (protected, limit 5); lung: 20.7 nTPM (vital, limit 2); small intestine: 16.9 nTPM (vital, limit 1); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 5); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); kidney: 15.3 nTPM (vital, limit 2); adipose tissue: 15.3 nTPM (protected, limit 5); stomach: 13.1 nTPM (protected, limit 5); colon: 12.9 nTPM (protected, limit 5); rectum: 12.7 nTPM (protected, limit 5); heart muscle: 12.7 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); thyroid gland: 12.2 nTPM (protected, limit 5); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 5); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000156313,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,32,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (protected, limit 5); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (protected, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 5); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 5); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); kidney: 6 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RPGR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (protected, limit 5); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (protected, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 5); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 5); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); kidney: 6 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); gallbladder: 5.4 nTPM (protected, limit 5); esophagus: 5.3 nTPM (protected, limit 5); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000156384,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.2,8.8,"spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); urinary bladder: 5.2 nTPM (protected, limit 5); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); amygdala: 5 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SFR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); appendix: 7 nTPM (protected, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); lung: 6.1 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 5); basal ganglia: 5.2 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 5); colon: 5.1 nTPM (protected, limit 5); amygdala: 5 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000156466,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; thymus,GDF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000156500,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,7.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PABIR3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000156509,True,compatible,,True,0,80,unavailable,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,FBXO43,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000156876,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,5.9,4.1,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,SASS6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000156970,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.6,12.3,"bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,BUB1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 5); appendix: 6.5 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157014,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,34,21.1,"bone marrow: 34 nTPM (vital, limit 1); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 5); thyroid gland: 20.2 nTPM (protected, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 5); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 5); kidney: 17.3 nTPM (vital, limit 1); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 5); urinary bladder: 16 nTPM (protected, limit 5); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 5); adipose tissue: 15 nTPM (protected, limit 5); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 5); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 5); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TATDN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 34 nTPM (vital, limit 1); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 5); thyroid gland: 20.2 nTPM (protected, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 5); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 5); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 5); urinary bladder: 16 nTPM (protected, limit 5); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (protected, limit 5); colon: 15 nTPM (protected, limit 5); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); appendix: 14.3 nTPM (protected, limit 5); rectum: 14.2 nTPM (protected, limit 5); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 5); gallbladder: 10 nTPM (protected, limit 5); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000157060,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0,0,,kidney / distal tubules: Medium (Enhanced),51,not_established,not_triggered,,,SHCBP1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,False,False,,kidney / distal tubules: Medium (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000157093,True,compatible,,True,0,1,partial,1,0,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,LYZL4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000157168,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,16.5,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (protected, limit 5); urinary bladder: 8.9 nTPM (protected, limit 5); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NRG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (protected, limit 5); urinary bladder: 8.9 nTPM (protected, limit 5); kidney: 8 nTPM (vital, limit 1); appendix: 5.7 nTPM (protected, limit 5); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000157322,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,23.2,0.5,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLEC18A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157330,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,45.3,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,CFAP107,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157343,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,10.9,2.3,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ARMC12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157423,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,6.6,2.4,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,HYDIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000157429,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,10.6,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); gallbladder: 6 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000157445,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.2,10.3,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 5); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CACNA2D3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 5); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157456,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,73.6,32.2,"bone marrow: 73.6 nTPM (vital, limit 1); lymph node: 32.2 nTPM (protected, limit 5); rectum: 16.3 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); colon: 13.8 nTPM (protected, limit 5); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCNB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 73.6 nTPM (vital, limit 1); lymph node: 32.2 nTPM (protected, limit 5); rectum: 16.3 nTPM (protected, limit 5); esophagus: 15.7 nTPM (protected, limit 5); colon: 13.8 nTPM (protected, limit 5); duodenum: 13.7 nTPM (vital, limit 1); appendix: 11.8 nTPM (protected, limit 5); small intestine: 11.7 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / endocrine cells: High (Enhanced); appendix / germinal center cells: Medium (Enhanced); appendix / non-germinal center cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000157578,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,10.5,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LCA5L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000157653,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,0.9,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C9orf43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157703,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.8,4,"choroid plexus: 8.8 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; thymus,SVOPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 8.8 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000157884,True,compatible,,True,0,80,unavailable,0.9,2.4,,,0,not_established,not_triggered,,,CIB4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000158402,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,5.7,3.9,"bone marrow: 5.7 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),40,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CDC25C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 5.7 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000158423,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,27.4,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RIBC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000158497,True,compatible,,True,0,80,unavailable,0.9,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; thymus; tonsil,HMHB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000158525,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,1.8,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,CPA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000158553,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POM121L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000158639,True,compatible,,True,0,2,partial,1,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,PAGE5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000158683,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,2.5,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PKD1L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000158769,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,71.4,83.1,"esophagus: 83.1 nTPM (protected, limit 5); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 5); colon: 51 nTPM (protected, limit 5); urinary bladder: 50.3 nTPM (protected, limit 5); rectum: 50.1 nTPM (protected, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (protected, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 5); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); adipose tissue: 20.4 nTPM (protected, limit 10); pituitary gland: 18.3 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 5); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 5); hippocampal formation: 5.8 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 5); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,F11R,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 83.1 nTPM (protected, limit 5); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 5); colon: 51 nTPM (protected, limit 5); urinary bladder: 50.3 nTPM (protected, limit 5); rectum: 50.1 nTPM (protected, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (protected, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 5); gallbladder: 27.7 nTPM (protected, limit 5); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); adipose tissue: 20.4 nTPM (protected, limit 10); appendix: 20.3 nTPM (protected, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 5); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 5); hippocampal formation: 5.8 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 5); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000158987,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,17.3,20.6,"lymph node: 20.6 nTPM (protected, limit 5); cerebellum: 17.3 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 5); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAPGEF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 20.6 nTPM (protected, limit 5); cerebellum: 17.3 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); appendix: 12.3 nTPM (protected, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 5); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); gallbladder: 5.5 nTPM (protected, limit 5); rectum: 5.4 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000159079,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,67.7,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 5); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (protected, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 10); stomach: 28.4 nTPM (protected, limit 5); liver: 28.3 nTPM (vital, limit 5); adrenal gland: 28.2 nTPM (vital, limit 1); spinal cord: 27.5 nTPM (vital, limit 1); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 5); colon: 25.6 nTPM (protected, limit 5); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 5); adipose tissue: 22.6 nTPM (protected, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 10); lymph node: 16.1 nTPM (protected, limit 5); bone marrow: 13.9 nTPM (vital, limit 5); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 5); tongue: 11.3 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CFAP298,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 5); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (protected, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 10); stomach: 28.4 nTPM (protected, limit 5); liver: 28.3 nTPM (vital, limit 5); adrenal gland: 28.2 nTPM (vital, limit 1); spinal cord: 27.5 nTPM (vital, limit 1); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 5); colon: 25.6 nTPM (protected, limit 5); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 5); adipose tissue: 22.6 nTPM (protected, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 10); lymph node: 16.1 nTPM (protected, limit 5); bone marrow: 13.9 nTPM (vital, limit 5); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 5); appendix: 11.8 nTPM (protected, limit 5); gallbladder: 11.6 nTPM (protected, limit 5); tongue: 11.3 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000159082,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,46.9,8.1,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); kidney: 7.1 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 5); tongue: 6.2 nTPM (protected, limit 5); lymph node: 6.1 nTPM (protected, limit 5); small intestine: 6.1 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 5); colon: 5.5 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); rectum: 5.3 nTPM (protected, limit 5); smooth muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,SYNJ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); kidney: 7.1 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 5); lymph node: 6.1 nTPM (protected, limit 5); small intestine: 6.1 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 5); colon: 5.5 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); rectum: 5.3 nTPM (protected, limit 5); appendix: 5.1 nTPM (protected, limit 5); smooth muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000159131,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,28.7,31,"urinary bladder: 31 nTPM (protected, limit 5); lymph node: 29.5 nTPM (protected, limit 5); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 5); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 5); adipose tissue: 23.3 nTPM (protected, limit 5); colon: 22.4 nTPM (protected, limit 5); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 5); thyroid gland: 20.2 nTPM (protected, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); stomach: 19.2 nTPM (protected, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 5); small intestine: 18.8 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GART,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"urinary bladder: 31 nTPM (protected, limit 5); lymph node: 29.5 nTPM (protected, limit 5); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 5); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 5); appendix: 23.5 nTPM (protected, limit 5); adipose tissue: 23.3 nTPM (protected, limit 5); colon: 22.4 nTPM (protected, limit 5); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 5); thyroid gland: 20.2 nTPM (protected, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 5); stomach: 19.2 nTPM (protected, limit 5); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); lung: 15.5 nTPM (vital, limit 1); gallbladder: 15.3 nTPM (protected, limit 5); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000159217,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,1.2,0.3,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,IGF2BP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000159224,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,10,partial,251.8,1.2,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),68,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus,GIP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000159289,True,compatible,,True,0,1,partial,2.2,0.1,,,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,GOLGA6A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000159374,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,M1AP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000159495,True,compatible,,True,0,80,unavailable,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,TGM7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000159625,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12,0.7,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,DRC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000159708,True,compatible,,True,0,3,partial,4.8,0.5,,,46,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,LRRC36,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,True,True,,,,unchanged
ENSG00000159761,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,10,4,"cerebellum: 10 nTPM (vital, limit 5); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C16orf86,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 10 nTPM (vital, limit 5); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000159882,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.5,3.3,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF230,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000159905,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,2.2,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF221,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000159915,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.7,2.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF233,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160062,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,4.9,5.9,"tongue: 5.9 nTPM (protected, limit 5); thyroid gland: 5.3 nTPM (protected, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZBTB8A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 5.9 nTPM (protected, limit 5); thyroid gland: 5.3 nTPM (protected, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000160161,True,compatible,,True,0,80,unavailable,1,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,CILP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000160207,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,2.4,0.7,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HSF2BP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000160318,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.5,4.8,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLDND2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160321,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.9,12.8,"parathyroid gland: 12.8 nTPM (protected, limit 5); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF208,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 12.8 nTPM (protected, limit 5); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160352,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.8,13.9,"thyroid gland: 13.9 nTPM (protected, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); cerebellum: 6.3 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 5); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF714,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 13.9 nTPM (protected, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); cerebellum: 6.3 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 5); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160396,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.8,0.5,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,HIPK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160471,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,6.5,"colon: 6.5 nTPM (protected, limit 5); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,COX6B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"colon: 6.5 nTPM (protected, limit 5); bone marrow: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160505,True,compatible,,True,0,80,unavailable,0.2,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,NLRP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000160838,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.1,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,LRRC71,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160882,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,3571.8,0.4,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,CYP11B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000160886,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,5.2,12.1,"esophagus: 12.1 nTPM (protected, limit 10); skeletal muscle: 5.2 nTPM (vital, limit 5); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LY6K,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"esophagus: 12.1 nTPM (protected, limit 10); skeletal muscle: 5.2 nTPM (vital, limit 5); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000160994,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0.2,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,TEKTL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000161036,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,26.8,9.7,"cerebellum: 26.8 nTPM (vital, limit 5); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 5); adrenal gland: 16.2 nTPM (vital, limit 5); bone marrow: 14.8 nTPM (vital, limit 5); liver: 14.6 nTPM (vital, limit 5); cerebral cortex: 13.8 nTPM (vital, limit 5); hypothalamus: 13.8 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 5); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 5); choroid plexus: 11 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 5); pancreas: 9 nTPM (vital, limit 5); spinal cord: 8.9 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 5); tongue: 5.1 nTPM (protected, limit 5); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRWD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 26.8 nTPM (vital, limit 5); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 5); adrenal gland: 16.2 nTPM (vital, limit 5); bone marrow: 14.8 nTPM (vital, limit 5); liver: 14.6 nTPM (vital, limit 5); cerebral cortex: 13.8 nTPM (vital, limit 5); hypothalamus: 13.8 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 5); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 5); choroid plexus: 11 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 5); pancreas: 9 nTPM (vital, limit 5); spinal cord: 8.9 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 5); tongue: 5.1 nTPM (protected, limit 5); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161040,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,2.6,4.9,"retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FBXL13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161180,True,compatible,,True,0,80,unavailable,0.6,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC116,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000161217,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,71.2,40.4,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); tongue: 40.4 nTPM (protected, limit 5); adipose tissue: 30.3 nTPM (protected, limit 5); esophagus: 29.9 nTPM (protected, limit 5); colon: 24.8 nTPM (protected, limit 5); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 5); lymph node: 22.3 nTPM (protected, limit 5); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 5); parathyroid gland: 21.9 nTPM (protected, limit 5); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 5); liver: 20 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (protected, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PCYT1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); tongue: 40.4 nTPM (protected, limit 5); adipose tissue: 30.3 nTPM (protected, limit 5); esophagus: 29.9 nTPM (protected, limit 5); appendix: 29.2 nTPM (protected, limit 5); colon: 24.8 nTPM (protected, limit 5); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 5); lymph node: 22.3 nTPM (protected, limit 5); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 5); parathyroid gland: 21.9 nTPM (protected, limit 5); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 5); gallbladder: 20 nTPM (protected, limit 5); liver: 20 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (protected, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000161405,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,11.8,35.6,"lymph node: 35.6 nTPM (protected, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,IKZF3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 35.6 nTPM (protected, limit 5); appendix: 18.2 nTPM (protected, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1)",appendix / non-germinal center cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161594,True,compatible,,True,0,2,partial,0.7,0.8,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,KLHL10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000161609,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,11.5,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KASH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161652,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,IZUMO2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000161654,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,35.8,27.3,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 5); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 5); tongue: 22.8 nTPM (protected, limit 5); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 5); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 5); lymph node: 20.3 nTPM (protected, limit 5); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 5); adipose tissue: 19.3 nTPM (protected, limit 5); colon: 19.1 nTPM (protected, limit 5); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (protected, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LSM12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 5); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 5); tongue: 22.8 nTPM (protected, limit 5); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 5); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 5); lymph node: 20.3 nTPM (protected, limit 5); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 5); adipose tissue: 19.3 nTPM (protected, limit 5); colon: 19.1 nTPM (protected, limit 5); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (protected, limit 5); basal ganglia: 16.7 nTPM (vital, limit 1); duodenum: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); appendix: 16.5 nTPM (protected, limit 5); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); choroid plexus: 16 nTPM (vital, limit 1); gallbladder: 14.9 nTPM (protected, limit 5); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161798,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,14.9,51,"stomach: 51 nTPM (protected, limit 5); esophagus: 16 nTPM (protected, limit 10); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,AQP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"stomach: 51 nTPM (protected, limit 5); esophagus: 16 nTPM (protected, limit 10); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000161850,True,compatible,,True,0,2,partial,0,0.3,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,KRT82,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000161860,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.2,1.1,"retina: 1.4 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000161973,True,compatible,,True,0,80,unavailable,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,CCDC42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000162039,True,compatible,,True,0,80,unavailable,0.7,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; thymus,MEIOB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000162062,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,4,2.2,"bone marrow: 4 nTPM (vital, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,TEDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4 nTPM (vital, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162129,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,10,7.5,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 5); pancreas: 5.6 nTPM (vital, limit 1); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CLPB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 5); appendix: 5.9 nTPM (protected, limit 5); pancreas: 5.6 nTPM (vital, limit 1); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162148,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,14,partial,52,7.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 5); liver: 7.5 nTPM (vital, limit 5); cerebral cortex: 7.1 nTPM (vital, limit 5); cerebellum: 7 nTPM (vital, limit 5); kidney: 6.3 nTPM (vital, limit 5); colon: 6.2 nTPM (protected, limit 5); midbrain: 5.6 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 5); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SAXO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 5); liver: 7.5 nTPM (vital, limit 5); cerebral cortex: 7.1 nTPM (vital, limit 5); cerebellum: 7 nTPM (vital, limit 5); kidney: 6.3 nTPM (vital, limit 5); colon: 6.2 nTPM (protected, limit 5); midbrain: 5.6 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 5); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",appendix / enterocytes - Microvilli: Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162300,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,39.5,30.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 5); spinal cord: 30.1 nTPM (vital, limit 1); adipose tissue: 29.8 nTPM (protected, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 5); colon: 29.5 nTPM (protected, limit 5); esophagus: 29.1 nTPM (protected, limit 5); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (protected, limit 5); hypothalamus: 25 nTPM (vital, limit 1); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 5); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 5); rectum: 8.8 nTPM (protected, limit 5); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZFPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 5); adipose tissue: 29.8 nTPM (protected, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 5); stomach: 29.5 nTPM (protected, limit 5); esophagus: 29.1 nTPM (protected, limit 5); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (protected, limit 5); hypothalamus: 25 nTPM (vital, limit 1); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 5); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 5); appendix: 11.2 nTPM (protected, limit 5); gallbladder: 9.6 nTPM (protected, limit 5); rectum: 8.8 nTPM (protected, limit 5); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162526,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.5,3.7,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,TSSK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000162543,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,23.1,9.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 5); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); lung: 5.1 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,UBXN10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 5); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); lung: 5.1 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162571,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,TTLL10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000162592,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CCDC27,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000162620,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,1.9,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRRIQ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162624,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,1,"basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,LHX8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"basal ganglia: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000162639,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,13.1,13.1,"lymph node: 13.1 nTPM (protected, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 5); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); urinary bladder: 6 nTPM (protected, limit 5); tongue: 5.9 nTPM (protected, limit 5); adipose tissue: 5.2 nTPM (protected, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,HENMT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lymph node: 13.1 nTPM (protected, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 5); amygdala: 7.9 nTPM (vital, limit 1); appendix: 7.8 nTPM (protected, limit 5); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); gallbladder: 6.3 nTPM (protected, limit 5); urinary bladder: 6 nTPM (protected, limit 5); tongue: 5.9 nTPM (protected, limit 5); adipose tissue: 5.2 nTPM (protected, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162641,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,AKNAD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000162753,False,excluded,positive_ihc_outside_permitted,True,0,10,partial,0.8,0.1,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,SLC9C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000162763,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,3.9,"choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,LRRC52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000162771,True,compatible,,True,0,4,partial,0.4,0.3,,,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; thymus,GARIN4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000162779,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,0.3,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),44,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,AXDND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000162782,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,2.3,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,TDRD5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162814,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,2.7,2.5,"choroid plexus: 2.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPATA17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,False,False,"choroid plexus: 2.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162843,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,WDR64,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000162852,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,30.7,37.4,"tongue: 37.4 nTPM (protected, limit 5); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 5); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 5); cerebral cortex: 15.5 nTPM (vital, limit 1); thyroid gland: 13.5 nTPM (protected, limit 5); colon: 13.3 nTPM (protected, limit 5); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (protected, limit 5); rectum: 11.6 nTPM (protected, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); parathyroid gland: 10.9 nTPM (protected, limit 5); urinary bladder: 10.9 nTPM (protected, limit 5); pancreas: 9.9 nTPM (vital, limit 1); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,CNST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 37.4 nTPM (protected, limit 5); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 5); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 5); cerebral cortex: 15.5 nTPM (vital, limit 1); thyroid gland: 13.5 nTPM (protected, limit 5); colon: 13.3 nTPM (protected, limit 5); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (protected, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 5); urinary bladder: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.9 nTPM (protected, limit 5); appendix: 10.2 nTPM (protected, limit 5); duodenum: 9.9 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); gallbladder: 8.4 nTPM (protected, limit 5); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000162928,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,24.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 5); thyroid gland: 13.3 nTPM (protected, limit 5); tongue: 13.1 nTPM (protected, limit 5); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 5); colon: 9.9 nTPM (protected, limit 5); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 5); stomach: 9.8 nTPM (protected, limit 5); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 5); adipose tissue: 9.2 nTPM (protected, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); hippocampal formation: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PEX13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); thyroid gland: 13.3 nTPM (protected, limit 5); urinary bladder: 13.3 nTPM (protected, limit 5); tongue: 13.1 nTPM (protected, limit 5); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 5); colon: 9.9 nTPM (protected, limit 5); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 5); stomach: 9.8 nTPM (protected, limit 5); small intestine: 9.5 nTPM (vital, limit 1); adipose tissue: 9.2 nTPM (protected, limit 5); parathyroid gland: 9.2 nTPM (protected, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); gallbladder: 8.5 nTPM (protected, limit 5); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 5); appendix: 6.5 nTPM (protected, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162931,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,46.1,3.1,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,TRIM17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000162994,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.5,5.2,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 5); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLHC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 5); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000162999,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3,3.8,"heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DUSP19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163006,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.4,4.3,"bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,CCDC138,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163012,True,compatible,,True,0,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,ZSWIM2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000163060,False,excluded,positive_ihc_outside_permitted,True,0,9,partial,0.6,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),47,not_established,not_triggered,,,TEKT4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000163114,True,compatible,,True,0,1,partial,0,0,,,47,not_established,not_triggered,,,PDHA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000163206,True,compatible,,True,0,2,partial,1.2,0.2,,,47,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,SMCP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000163239,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.8,10.7,"adipose tissue: 10.7 nTPM (protected, limit 5); thyroid gland: 10.7 nTPM (protected, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TDRD10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"adipose tissue: 10.7 nTPM (protected, limit 5); thyroid gland: 10.7 nTPM (protected, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163254,False,excluded,positive_ihc_outside_permitted,True,0,0,routine_complete,0.1,0,,eye / lens fiber cells: High (Supported),52,not_established,not_triggered,,,CRYGC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,eye / lens fiber cells: High (Supported),positive_ihc_outside_permitted,unchanged
ENSG00000163263,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,0.4,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,CFAP141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163283,False,excluded,positive_ihc_outside_permitted,True,0,12,partial,3.8,0,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,ALPP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000163286,False,excluded,positive_ihc_outside_permitted,True,0,11,partial,0.4,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); small intestine / enterocytes - Microvilli: High (Approved),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; thymus,ALPG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); small intestine / enterocytes - Microvilli: High (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000163312,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,8.8,9.1,"lymph node: 9.1 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (protected, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,HELQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 9.1 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (protected, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163322,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,7.6,7.8,"lymph node: 7.8 nTPM (protected, limit 5); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ABRAXAS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"lymph node: 7.8 nTPM (protected, limit 5); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); gallbladder: 5.5 nTPM (protected, limit 5); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163357,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.2,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,DCST1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 2.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163376,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,13.7,19.9,"lymph node: 19.9 nTPM (protected, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KBTBD8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 19.9 nTPM (protected, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); appendix: 6.7 nTPM (protected, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163421,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,63.7,7,"bone marrow: 63.7 nTPM (vital, limit 2); lung: 12.7 nTPM (vital, limit 2); adipose tissue: 7 nTPM (protected, limit 5); urinary bladder: 5.8 nTPM (protected, limit 5); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PROK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 63.7 nTPM (vital, limit 2); appendix: 17.2 nTPM (protected, limit 5); lung: 12.7 nTPM (vital, limit 2); adipose tissue: 7 nTPM (protected, limit 5); urinary bladder: 5.8 nTPM (protected, limit 5); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163424,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0.1,0,,bronchus / respiratory epithelial cells: Low (Enhanced),46,not_established,not_triggered,,,TEX55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000163440,True,compatible,,True,0,1,partial,0.1,0.3,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PDCL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000163467,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TSACC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163491,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.4,14.1,"tongue: 14.1 nTPM (protected, limit 5); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NEK10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"tongue: 14.1 nTPM (protected, limit 5); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163507,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,3.9,3.7,"bone marrow: 3.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CIP2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163512,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,20.6,26.1,"adipose tissue: 26.1 nTPM (protected, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thyroid gland: 13.6 nTPM (protected, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 5); liver: 10.9 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 5); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 5); spinal cord: 9.8 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 5); rectum: 9.5 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AZI2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 26.1 nTPM (protected, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); skeletal muscle: 13.6 nTPM (vital, limit 1); thyroid gland: 13.6 nTPM (protected, limit 5); pituitary gland: 13.5 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); gallbladder: 12.7 nTPM (protected, limit 5); parathyroid gland: 12.4 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 5); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 5); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 5); spinal cord: 9.8 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 5); rectum: 9.5 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); appendix: 8.8 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163527,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,72.6,78.4,"thyroid gland: 78.4 nTPM (protected, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 5); liver: 72.6 nTPM (vital, limit 1); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 5); lymph node: 58.5 nTPM (protected, limit 5); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 5); tongue: 55.6 nTPM (protected, limit 5); smooth muscle: 55.6 nTPM (vital, limit 1); urinary bladder: 54.6 nTPM (protected, limit 5); stomach: 53.7 nTPM (protected, limit 5); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); esophagus: 43.3 nTPM (protected, limit 5); adipose tissue: 41.3 nTPM (protected, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,STT3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 78.4 nTPM (protected, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 5); liver: 72.6 nTPM (vital, limit 1); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 5); lymph node: 58.5 nTPM (protected, limit 5); gallbladder: 58.2 nTPM (protected, limit 5); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 5); tongue: 55.6 nTPM (protected, limit 5); smooth muscle: 55.6 nTPM (vital, limit 1); urinary bladder: 54.6 nTPM (protected, limit 5); stomach: 53.7 nTPM (protected, limit 5); appendix: 50.8 nTPM (protected, limit 5); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); esophagus: 43.3 nTPM (protected, limit 5); adipose tissue: 41.3 nTPM (protected, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163530,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,DPPA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000163535,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,6.7,7.8,"lymph node: 7.8 nTPM (protected, limit 5); bone marrow: 6.7 nTPM (vital, limit 5); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,SGO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"lymph node: 7.8 nTPM (protected, limit 5); bone marrow: 6.7 nTPM (vital, limit 5); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",appendix / endocrine cells: Medium (Enhanced); bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163554,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,74.7,0.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / melanocytes; spleen; thymus,SPTA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163645,True,compatible,,True,0,4,partial,0.6,1.3,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ERICH6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000163646,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,12.4,0,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,CLRN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000163684,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,39.2,37.5,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 5); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 5); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); pituitary gland: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.3 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 5); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RPP14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 5); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 5); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 5); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); pituitary gland: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.3 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 5); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163689,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,7.7,"esophagus: 7.7 nTPM (protected, limit 5); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP20DC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 7.7 nTPM (protected, limit 5); pituitary gland: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163705,True,compatible,,True,0,80,unavailable,1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,FANCD2OS,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000163746,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,PLSCR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"bone marrow: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163749,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,CCDC158,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"liver: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163793,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,2.2,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,46,not_established,required,lymphatic_and_immune_function_review,lymph node,DNAJC5G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000163806,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,2.3,1.2,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SPDYA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000163808,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,5.1,2.2,"bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,KIF15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163867,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,15.3,9.3,"bone marrow: 15.3 nTPM (vital, limit 1); lymph node: 9.3 nTPM (protected, limit 5); thyroid gland: 9.2 nTPM (protected, limit 5); retina: 9 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); rectum: 7.2 nTPM (protected, limit 5); stomach: 7 nTPM (protected, limit 5); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); urinary bladder: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.1 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZMYM6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 15.3 nTPM (vital, limit 1); lymph node: 9.3 nTPM (protected, limit 5); thyroid gland: 9.2 nTPM (protected, limit 5); retina: 9 nTPM (vital, limit 1); appendix: 8.1 nTPM (protected, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); rectum: 7.2 nTPM (protected, limit 5); stomach: 7 nTPM (protected, limit 5); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); gallbladder: 6.2 nTPM (protected, limit 5); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (protected, limit 5); urinary bladder: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.1 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000163879,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,77.1,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 5); liver: 11.7 nTPM (vital, limit 5); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (protected, limit 10); lung: 10.1 nTPM (vital, limit 5); pancreas: 8.9 nTPM (vital, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 5); stomach: 6.2 nTPM (protected, limit 5); adrenal gland: 5.9 nTPM (vital, limit 5); colon: 5.1 nTPM (protected, limit 5); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,DNALI1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 5); liver: 11.7 nTPM (vital, limit 5); retina: 11.5 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (protected, limit 10); lung: 10.1 nTPM (vital, limit 5); pancreas: 8.9 nTPM (vital, limit 5); gallbladder: 8.8 nTPM (protected, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 5); stomach: 6.2 nTPM (protected, limit 5); adrenal gland: 5.9 nTPM (vital, limit 5); colon: 5.1 nTPM (protected, limit 5); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",appendix / enterocytes - Gradient: Ascending (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); gallbladder / glandular cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163885,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,13,0.1,"choroid plexus: 13 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 5); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),58,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,CFAP100,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 13 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 5); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163923,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,19.8,12.9,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); lymph node: 12.9 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); amygdala: 11.7 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); urinary bladder: 8.2 nTPM (protected, limit 5); smooth muscle: 7.9 nTPM (vital, limit 2); adipose tissue: 7.5 nTPM (protected, limit 5); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,RPL39L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); lymph node: 12.9 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); amygdala: 11.7 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); urinary bladder: 8.2 nTPM (protected, limit 5); smooth muscle: 7.9 nTPM (vital, limit 2); appendix: 7.7 nTPM (protected, limit 5); adipose tissue: 7.5 nTPM (protected, limit 5); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 5); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000163958,True,compatible,,True,0,80,unavailable,0.8,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ZDHHC19,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000164023,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,16,partial,27.7,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (protected, limit 5); esophagus: 15.8 nTPM (protected, limit 7.5); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 5); urinary bladder: 13.4 nTPM (protected, limit 5); colon: 11.9 nTPM (protected, limit 5); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 5); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (protected, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SGMS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"gallbladder: 38.2 nTPM (protected, limit 5); smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (protected, limit 5); esophagus: 15.8 nTPM (protected, limit 7.5); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); urinary bladder: 13.4 nTPM (protected, limit 5); stomach: 13.4 nTPM (protected, limit 5); colon: 11.9 nTPM (protected, limit 5); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 5); heart muscle: 8.8 nTPM (vital, limit 1); appendix: 8.7 nTPM (protected, limit 5); adipose tissue: 8.2 nTPM (protected, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); appendix / endocrine cells: High (Supported); appendix / enterocytes: High (Supported); appendix / enterocytes - Microvilli: High (Supported); appendix / goblet cells: High (Supported); appendix / non-germinal center cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000164037,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,1,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC9B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164045,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15.1,4.3,"bone marrow: 15.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CDC25A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 15.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164070,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,26.1,13.3,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 10); kidney: 12.9 nTPM (vital, limit 5); adrenal gland: 10.9 nTPM (vital, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 10); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 5); heart muscle: 6.2 nTPM (vital, limit 5); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HSPA4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 10); kidney: 12.9 nTPM (vital, limit 5); adrenal gland: 10.9 nTPM (vital, limit 5); parathyroid gland: 10.8 nTPM (protected, limit 10); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 5); heart muscle: 6.2 nTPM (vital, limit 5); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164113,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,ADAD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164123,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,not_triggered,,,SPMIP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164175,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.2,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SLC45A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164220,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.8,3.4,"retina: 4.8 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,F2RL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"gallbladder: 6.6 nTPM (protected, limit 5); retina: 4.8 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164241,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.7,11.5,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 5); thyroid gland: 8.6 nTPM (protected, limit 5); lymph node: 8 nTPM (protected, limit 5); stomach: 7.4 nTPM (protected, limit 5); pituitary gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C5orf63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 5); thyroid gland: 8.6 nTPM (protected, limit 5); lymph node: 8 nTPM (protected, limit 5); stomach: 7.4 nTPM (protected, limit 5); pituitary gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164256,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PRDM9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000164287,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CDC20B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,False,False,"kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164299,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164304,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,CAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164334,True,compatible,,True,0,4,partial,0.2,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,FAM170A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164399,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,IL3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000164404,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,1.6,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GDF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164414,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,36.4,46.1,"rectum: 46.1 nTPM (protected, limit 5); colon: 38.3 nTPM (protected, limit 5); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); stomach: 28.5 nTPM (protected, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 5); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 5); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 5); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (protected, limit 5); adipose tissue: 15.8 nTPM (protected, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 5); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 5); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC35A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"rectum: 46.1 nTPM (protected, limit 5); colon: 38.3 nTPM (protected, limit 5); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); stomach: 28.5 nTPM (protected, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 5); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 5); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); gallbladder: 18.9 nTPM (protected, limit 5); basal ganglia: 18.9 nTPM (vital, limit 1); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 5); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (protected, limit 5); adipose tissue: 15.8 nTPM (protected, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); appendix: 15.1 nTPM (protected, limit 5); tongue: 15 nTPM (protected, limit 5); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 5); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164451,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CALHM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"choroid plexus: 3.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164483,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.7,10.1,"lymph node: 10.1 nTPM (protected, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SAMD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 10.1 nTPM (protected, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164500,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,SPMIP7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164506,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,9.6,36.8,"parathyroid gland: 36.8 nTPM (protected, limit 5); cerebral cortex: 9.6 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 5); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 5); retina: 5.1 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,STXBP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 36.8 nTPM (protected, limit 5); cerebral cortex: 9.6 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 5); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 5); retina: 5.1 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000164508,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,2,partial,0.3,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H2AC1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,False,False,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000164512,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.8,3.5,"hypothalamus: 3.8 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ANKRD55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hypothalamus: 3.8 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164542,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.4,11.3,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 5); stomach: 10.8 nTPM (protected, limit 5); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MATCAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 5); stomach: 10.8 nTPM (protected, limit 5); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164556,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,CFAP144P1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000164611,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,157.9,79.5,"bone marrow: 157.9 nTPM (vital, limit 1); lymph node: 79.5 nTPM (protected, limit 5); thyroid gland: 76.9 nTPM (protected, limit 10); esophagus: 58 nTPM (protected, limit 5); rectum: 42.6 nTPM (protected, limit 5); colon: 32.7 nTPM (protected, limit 5); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 5); urinary bladder: 12.1 nTPM (protected, limit 10); stomach: 11.5 nTPM (protected, limit 10); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 5); cerebral cortex: 7.8 nTPM (vital, limit 5); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PTTG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 157.9 nTPM (vital, limit 1); lymph node: 79.5 nTPM (protected, limit 5); thyroid gland: 76.9 nTPM (protected, limit 10); esophagus: 58 nTPM (protected, limit 5); rectum: 42.6 nTPM (protected, limit 5); colon: 32.7 nTPM (protected, limit 5); appendix: 24.4 nTPM (protected, limit 5); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 5); urinary bladder: 12.1 nTPM (protected, limit 10); stomach: 11.5 nTPM (protected, limit 10); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 5); cerebral cortex: 7.8 nTPM (vital, limit 5); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); gallbladder: 5.9 nTPM (protected, limit 5); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164627,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,8.9,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,KIF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164645,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,not_triggered,,,TEX47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000164663,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,8.7,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,USP49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164675,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,IQUB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164729,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,SLC35G3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000164744,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced),45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,SUN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000164746,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,7.6,0.8,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,C7orf57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164796,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,2.7,0,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,CSMD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000164815,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,16.9,12.4,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 5); lymph node: 11.9 nTPM (protected, limit 5); colon: 11.6 nTPM (protected, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 5); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (protected, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 5); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (protected, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ORC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 5); lymph node: 11.9 nTPM (protected, limit 5); colon: 11.6 nTPM (protected, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 5); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (protected, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 5); adrenal gland: 9.5 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (protected, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 5); appendix: 7.5 nTPM (protected, limit 5); pituitary gland: 7.3 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); gallbladder: 6.4 nTPM (protected, limit 5); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000164871,True,compatible,,True,0,3,partial,0.2,0.1,,,45,not_established,not_triggered,,,SPAG11B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000164898,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,29,37.1,"tongue: 37.1 nTPM (protected, limit 5); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 5); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 5); thyroid gland: 10.4 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 5); urinary bladder: 8.3 nTPM (protected, limit 5); adipose tissue: 8.2 nTPM (protected, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 5); lymph node: 5.3 nTPM (protected, limit 5); lung: 5 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FMC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 37.1 nTPM (protected, limit 5); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 5); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 5); thyroid gland: 10.4 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 5); urinary bladder: 8.3 nTPM (protected, limit 5); adipose tissue: 8.2 nTPM (protected, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 5); lymph node: 5.3 nTPM (protected, limit 5); lung: 5 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000164900,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,10.9,1,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,44,not_established,not_triggered,,,GBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000164944,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,27,14.3,"bone marrow: 27 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 5); lymph node: 14.1 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (protected, limit 5); adipose tissue: 12.1 nTPM (protected, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 5); rectum: 11.3 nTPM (protected, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.6 nTPM (vital, limit 2); colon: 9.6 nTPM (protected, limit 5); esophagus: 9.4 nTPM (protected, limit 5); tongue: 8.9 nTPM (protected, limit 5); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,VIRMA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 27 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 5); lymph node: 14.1 nTPM (protected, limit 5); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (protected, limit 5); adipose tissue: 12.1 nTPM (protected, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 5); stomach: 11.3 nTPM (protected, limit 5); appendix: 11.2 nTPM (protected, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 5); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.6 nTPM (vital, limit 2); colon: 9.6 nTPM (protected, limit 5); esophagus: 9.4 nTPM (protected, limit 5); tongue: 8.9 nTPM (protected, limit 5); small intestine: 8.8 nTPM (vital, limit 1); gallbladder: 8.6 nTPM (protected, limit 5); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000164975,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.6,11.4,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 5); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SNAPC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 5); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); gallbladder: 5.3 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000164989,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,5.2,1.9,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,CCDC171,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165059,True,compatible,,True,0,5,partial,0,0,,,46,not_established,not_triggered,,,PRKACG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000165076,True,compatible,,True,0,2,partial,0.1,0,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; thymus,PRSS37,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000165113,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,14,partial,48.5,25.5,"skeletal muscle: 48.5 nTPM (vital, limit 5); tongue: 25.5 nTPM (protected, limit 5); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 5); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 5); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 5); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 5); pancreas: 8.3 nTPM (vital, limit 5); kidney: 7.2 nTPM (vital, limit 5); adrenal gland: 6.3 nTPM (vital, limit 5); smooth muscle: 6 nTPM (vital, limit 5); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GKAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 48.5 nTPM (vital, limit 5); tongue: 25.5 nTPM (protected, limit 5); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 5); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 5); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 5); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 5); pancreas: 8.3 nTPM (vital, limit 5); kidney: 7.2 nTPM (vital, limit 5); adrenal gland: 6.3 nTPM (vital, limit 5); smooth muscle: 6 nTPM (vital, limit 5); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165120,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,SSMEM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000165131,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0.2,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,LLCFC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165181,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.7,1.1,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,SHOC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165182,True,compatible,,True,0,80,unavailable,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen; thymus,CXorf58,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000165188,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.2,4.8,"kidney: 11.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,RNF183,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 11.2 nTPM (vital, limit 1); gallbladder: 5.5 nTPM (protected, limit 5); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165204,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR1K1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000165244,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,25.8,4.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ZNF367,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000165309,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,50.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,ARMC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165325,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,DEUP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165383,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,23.9,0.6,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,LRRC18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165480,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,4.7,4.2,"bone marrow: 4.7 nTPM (vital, limit 2)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SKA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"bone marrow: 4.7 nTPM (vital, limit 2)",,rna_above_tissue_ceiling,unchanged
ENSG00000165490,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,7.7,4.3,"bone marrow: 7.7 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DDIAS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 7.7 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000165496,True,compatible,,True,0,80,unavailable,0.6,2.6,,,0,not_established,required,in_situ_inflammation_review,appendix,RPL10L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000165555,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,4.2,0.6,"retina: 4.2 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NOXRED1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 4.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165568,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.3,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,AKR1E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165583,True,compatible,,True,0,3,partial,0.2,0.1,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,SSX5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000165584,True,compatible,,True,0,3,partial,0.1,0.2,,,45,not_established,not_triggered,,,SSX3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000165643,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,41.6,0.1,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,SOHLH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165695,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,9.9,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AK8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165698,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,18.9,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (protected, limit 10); cerebral cortex: 14.9 nTPM (vital, limit 5); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 5); pituitary gland: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 10); heart muscle: 10 nTPM (vital, limit 5); cerebellum: 8.6 nTPM (vital, limit 5); retina: 7.9 nTPM (vital, limit 1); adrenal gland: 7.4 nTPM (vital, limit 5); lung: 7.2 nTPM (vital, limit 5); pancreas: 5.1 nTPM (vital, limit 5)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPACA9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (protected, limit 10); cerebral cortex: 14.9 nTPM (vital, limit 5); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 5); pituitary gland: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 10); heart muscle: 10 nTPM (vital, limit 5); cerebellum: 8.6 nTPM (vital, limit 5); retina: 7.9 nTPM (vital, limit 1); adrenal gland: 7.4 nTPM (vital, limit 5); lung: 7.2 nTPM (vital, limit 5); pancreas: 5.1 nTPM (vital, limit 5)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165805,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C12orf50,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000165807,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,10.4,7,"pancreas: 10.4 nTPM (vital, limit 5); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); rectum: 5.4 nTPM (protected, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PPP1R36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 10.4 nTPM (vital, limit 5); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 5); rectum: 5.4 nTPM (protected, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165828,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,1103.8,72.1,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 5); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 5)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 5); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 5)",appendix / enterocytes: Medium (Supported); duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000165837,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,ERICH6B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000165863,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,SPMIP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165891,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.9,1.5,"bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,E2F7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000165923,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,2.9,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AGBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000165970,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.9,0,,,0,not_established,not_triggered,,,SLC6A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000165972,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,0.2,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,CCDC38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"liver: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166024,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,17.2,12.7,"bone marrow: 17.2 nTPM (vital, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 5); adipose tissue: 12.4 nTPM (protected, limit 10); small intestine: 12 nTPM (vital, limit 1); urinary bladder: 12 nTPM (protected, limit 5); lymph node: 11.9 nTPM (protected, limit 5); colon: 11.7 nTPM (protected, limit 5); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 5); rectum: 9.8 nTPM (protected, limit 5); thyroid gland: 9.8 nTPM (protected, limit 5); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 5); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,R3HCC1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 17.2 nTPM (vital, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 5); adipose tissue: 12.4 nTPM (protected, limit 10); urinary bladder: 12 nTPM (protected, limit 5); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 5); colon: 11.7 nTPM (protected, limit 5); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 5); rectum: 9.8 nTPM (protected, limit 5); thyroid gland: 9.8 nTPM (protected, limit 5); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 5); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); appendix: 7.5 nTPM (protected, limit 5); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); gallbladder: 5.7 nTPM (protected, limit 5)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000166049,True,compatible,,True,0,2,partial,0,0,,,48,not_established,not_triggered,,,PASD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000166068,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,20,30.2,"thyroid gland: 30.2 nTPM (protected, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 5); adipose tissue: 12.2 nTPM (protected, limit 5); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); rectum: 10.6 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 5); parathyroid gland: 6.6 nTPM (protected, limit 5); esophagus: 5.9 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,SPRED1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 30.2 nTPM (protected, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 5); gallbladder: 12.3 nTPM (protected, limit 5); adipose tissue: 12.2 nTPM (protected, limit 5); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); rectum: 10.6 nTPM (protected, limit 5); stomach: 10 nTPM (protected, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); appendix: 8.6 nTPM (protected, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 5); parathyroid gland: 6.6 nTPM (protected, limit 5); esophagus: 5.9 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000166069,True,compatible,,True,0,1,partial,0.1,0.6,,,47,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,TMCO5A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166086,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,77,52.8,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 5); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 5); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (protected, limit 5); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 5); esophagus: 21.3 nTPM (protected, limit 5); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 5); thyroid gland: 15.3 nTPM (protected, limit 5); tongue: 14.1 nTPM (protected, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 5); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,JAM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 5); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 5); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); gallbladder: 24.3 nTPM (protected, limit 5); adipose tissue: 22.9 nTPM (protected, limit 5); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 5); esophagus: 21.3 nTPM (protected, limit 5); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 5); thyroid gland: 15.3 nTPM (protected, limit 5); tongue: 14.1 nTPM (protected, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 5); kidney: 11.1 nTPM (vital, limit 1); appendix: 10.5 nTPM (protected, limit 5); lymph node: 8.4 nTPM (protected, limit 5); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000166118,True,compatible,,True,0,3,partial,0.2,0.2,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,SPATA19,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166152,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C16orf78,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166192,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,6.1,5.5,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 5); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SENP8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 5); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000166206,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,45.7,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (protected, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 5); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,GABRB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); gallbladder: 13.2 nTPM (protected, limit 5); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (protected, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 5); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166220,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen; thymus,TBATA,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166246,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,11.2,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAAF8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000166263,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,4.4,5.8,"parathyroid gland: 5.8 nTPM (protected, limit 5); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,STXBP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 5.8 nTPM (protected, limit 5); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000166323,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C11orf65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166329,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CCDC182,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000166349,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.2,2.4,"bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RAG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166351,True,compatible,,True,0,80,unavailable,0.2,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,POTED,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166359,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,WDR88,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166368,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR2D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000166439,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,14.3,9.8,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); tongue: 5.6 nTPM (protected, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); liver: 4.9 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RNF169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); appendix: 6.5 nTPM (protected, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (protected, limit 5); tongue: 5.6 nTPM (protected, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); liver: 4.9 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166546,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,0.5,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,BEAN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166578,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,21.4,4.9,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IQCD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166743,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.8,2.2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACSM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166796,True,compatible,,True,0,2,partial,1.4,0.5,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,LDHC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000166800,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.5,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LDHAL6A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166845,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,2.9,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C18orf54,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166851,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,31.6,27.2,"bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 5); esophagus: 13.5 nTPM (protected, limit 5); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 5); colon: 9.3 nTPM (protected, limit 5); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PLK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 5); esophagus: 13.5 nTPM (protected, limit 5); appendix: 13 nTPM (protected, limit 5); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 5); colon: 9.3 nTPM (protected, limit 5); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000166884,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4D6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000166926,True,compatible,,True,0,80,unavailable,0.6,2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,MS4A6E,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000166928,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,11.6,4.9,"lung: 11.6 nTPM (vital, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MS4A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lung: 11.6 nTPM (vital, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000166930,True,compatible,,True,0,0,routine_complete,0.2,0,,,48,not_established,not_triggered,,,MS4A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000167014,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,TERB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"liver: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167094,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.4,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,TTC16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167098,True,compatible,,True,0,5,partial,0,0,,,45,not_established,not_triggered,,,SUN5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000167139,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,TBC1D21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000167194,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,34.7,0.1,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,C16orf92,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167195,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.7,0.2,"liver: 3.7 nTPM (vital, limit 3)",,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,GOLGA6C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"liver: 3.7 nTPM (vital, limit 3)",,rna_above_tissue_ceiling,unchanged
ENSG00000167210,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.7,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; thymus,LOXHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167311,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13,10,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 5); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus,ART5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 5); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167360,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR51Q1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000167377,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15.4,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); tongue: 6.9 nTPM (protected, limit 5); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); spinal cord: 5.8 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 5); rectum: 5.4 nTPM (protected, limit 5); adipose tissue: 5.3 nTPM (protected, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (protected, limit 5); tongue: 6.9 nTPM (protected, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); skeletal muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 5); colon: 5.4 nTPM (protected, limit 5); adipose tissue: 5.3 nTPM (protected, limit 5); liver: 5.2 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); appendix: 5.2 nTPM (protected, limit 5); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167394,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,7.8,6.2,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (protected, limit 5); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF668,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (protected, limit 5); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000167395,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,9.1,7,"bone marrow: 9.1 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 5); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 5); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF646,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.1 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 5); appendix: 6.5 nTPM (protected, limit 5); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (protected, limit 5); stomach: 5.4 nTPM (protected, limit 5); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 5); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000167397,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,443.7,97.3,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 5); adipose tissue: 96.2 nTPM (protected, limit 5); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 5); stomach: 85.4 nTPM (protected, limit 5); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (protected, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 5); parathyroid gland: 49.5 nTPM (protected, limit 5); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 5); lymph node: 35 nTPM (protected, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 5); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,VKORC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 5); adipose tissue: 96.2 nTPM (protected, limit 5); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 5); stomach: 85.4 nTPM (protected, limit 5); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (protected, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); gallbladder: 56.8 nTPM (protected, limit 5); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 5); parathyroid gland: 49.5 nTPM (protected, limit 5); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 5); appendix: 37.2 nTPM (protected, limit 5); lymph node: 35 nTPM (protected, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 5); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000167523,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,13.3,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 5); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 5); lung: 5.8 nTPM (vital, limit 5); midbrain: 5.7 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 5); spinal cord: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPATA33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,False,False,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 5); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 5); lung: 5.8 nTPM (vital, limit 5); midbrain: 5.7 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 5); spinal cord: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1)",appendix / enterocytes: Low (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000167525,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,8,2.3,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PROCA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167531,True,compatible,,True,0,4,partial,0,0.1,,,45,not_established,not_triggered,,,LALBA,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000167554,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,6,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF610,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000167562,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.3,5.7,"thyroid gland: 5.7 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF701,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 5.7 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000167612,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,3,partial,17.8,2,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),52,not_established,not_triggered,,,ANKRD33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000167632,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,32.4,26.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 5); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 5); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (protected, limit 5); stomach: 12.1 nTPM (protected, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 5); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); bone marrow: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); colon: 10.8 nTPM (protected, limit 5); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (protected, limit 5); lymph node: 7.8 nTPM (protected, limit 5); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRAPPC9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 5); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 5); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (protected, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 5); esophagus: 12 nTPM (protected, limit 5); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); bone marrow: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); colon: 10.8 nTPM (protected, limit 5); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (protected, limit 5); lymph node: 7.8 nTPM (protected, limit 5); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); appendix: 6.7 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); gallbladder: 5.6 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000167634,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,NLRP7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,True,True,,,,unchanged
ENSG00000167791,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,7.1,0,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,CABP2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 7.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000167981,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,2.3,2.1,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF597,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000167985,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,45.3,43.1,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 5); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 5); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 5); urinary bladder: 31.6 nTPM (protected, limit 5); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 5); esophagus: 28 nTPM (protected, limit 5); thyroid gland: 27.8 nTPM (protected, limit 5); stomach: 26.8 nTPM (protected, limit 5); adipose tissue: 26.6 nTPM (protected, limit 5); colon: 26.3 nTPM (protected, limit 5); small intestine: 26.3 nTPM (vital, limit 1); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SDHAF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 5); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 5); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 5); urinary bladder: 31.6 nTPM (protected, limit 5); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 5); esophagus: 28 nTPM (protected, limit 5); thyroid gland: 27.8 nTPM (protected, limit 5); stomach: 26.8 nTPM (protected, limit 5); adipose tissue: 26.6 nTPM (protected, limit 5); colon: 26.3 nTPM (protected, limit 5); small intestine: 26.3 nTPM (vital, limit 1); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); appendix: 25.7 nTPM (protected, limit 5); midbrain: 25.2 nTPM (vital, limit 1); gallbladder: 24.7 nTPM (protected, limit 5); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168026,True,compatible,,True,0,3,partial,1.2,0.8,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TTC21A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000168038,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,8.4,7.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 5); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ULK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 5); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168061,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,8.9,3.7,"skeletal muscle: 8.9 nTPM (vital, limit 1); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SAC3D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 8.9 nTPM (vital, limit 1); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168070,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,1.4,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MAJIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168078,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,9,12.5,"lymph node: 12.5 nTPM (protected, limit 5); bone marrow: 9 nTPM (vital, limit 5); duodenum: 8.1 nTPM (vital, limit 5); small intestine: 7.9 nTPM (vital, limit 5)",lymph node / germinal center cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,PBK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"lymph node: 12.5 nTPM (protected, limit 5); bone marrow: 9 nTPM (vital, limit 5); duodenum: 8.1 nTPM (vital, limit 5); small intestine: 7.9 nTPM (vital, limit 5)",lymph node / germinal center cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000168116,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,8.4,5.5,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 5); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,KIAA1586,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 5); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168148,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,6,partial,0.2,0.1,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H3-4,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1136/jitc-2023-007935,Wang 2016;Carter 2023,False,False,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000168152,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,5,6.6,"tongue: 6.6 nTPM (protected, limit 5); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,THAP9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"tongue: 6.6 nTPM (protected, limit 5); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168263,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,280.3,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KCNV2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;da Silva 2017,False,False,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000168267,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,101.2,1.9,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,PTF1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 101.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168314,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,1086.6,2.3,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 5)",cerebral cortex / neuropil: Medium (Enhanced),46,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,MOBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 5)",cerebral cortex / neuropil: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000168438,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,37.7,19.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (protected, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 5); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 5); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 5); tongue: 11.1 nTPM (protected, limit 5); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (protected, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); hippocampal formation: 10.6 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CDC40,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (protected, limit 5); retina: 14.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 5); appendix: 13 nTPM (protected, limit 5); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 5); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 5); skeletal muscle: 11.2 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 5); stomach: 11.1 nTPM (protected, limit 5); adipose tissue: 10.7 nTPM (protected, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); small intestine: 10.7 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); gallbladder: 10 nTPM (protected, limit 5); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168454,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0.3,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),47,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,TXNDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000168491,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,29.7,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC110,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168515,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,SCGB1D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000168589,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,56.3,4.4,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DYNLRB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168594,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ADAM29,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000168619,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,ADAM18,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000168658,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,5,partial,9.1,0.1,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,VWA3B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000168676,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,0.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KCTD19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 3.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000168702,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,9.7,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus,LRP1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000168757,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,TSPY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000168904,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,45.6,17.6,"liver: 45.6 nTPM (vital, limit 1); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 5); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); esophagus: 9.3 nTPM (protected, limit 5); parathyroid gland: 9.1 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 5); adipose tissue: 7.8 nTPM (protected, limit 5); colon: 7.7 nTPM (protected, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LRRC28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 45.6 nTPM (vital, limit 1); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 5); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 5); parathyroid gland: 9.1 nTPM (protected, limit 5); gallbladder: 8.8 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 5); adipose tissue: 7.8 nTPM (protected, limit 5); colon: 7.7 nTPM (protected, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000168930,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000168944,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.2,9.1,"retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 5); adipose tissue: 8 nTPM (protected, limit 5); thyroid gland: 8 nTPM (protected, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 5); pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 5); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CEP120,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 5); adipose tissue: 8 nTPM (protected, limit 5); thyroid gland: 8 nTPM (protected, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); gallbladder: 7 nTPM (protected, limit 5); appendix: 6.9 nTPM (protected, limit 5); colon: 6.9 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 5); hippocampal formation: 5.2 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169059,True,compatible,,True,0,1,partial,0.4,0.2,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,VCX3A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000169064,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,13.3,0.2,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,ZBBX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169126,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,7.8,1,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus,ODAD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169154,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,GOT1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000169169,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,28.5,3.3,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,CPT1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169194,True,compatible,,True,0,80,unavailable,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; thymus,IL13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000169214,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR6F1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000169248,False,excluded,rna_above_tissue_ceiling,True,0,0,routine_complete,9,11.6,"lymph node: 11.6 nTPM (protected, limit 5); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); stomach: 6.1 nTPM (protected, limit 5); lung: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CXCL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 11.6 nTPM (protected, limit 5); appendix: 10.8 nTPM (protected, limit 5); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); stomach: 6.1 nTPM (protected, limit 5); lung: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169340,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,0.4,119.4,"stomach: 119.4 nTPM (protected, limit 5)",stomach 2 / glandular cells: Low (Approved),48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PDILT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"stomach: 119.4 nTPM (protected, limit 5)",stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169393,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,72.3,0,"retina: 72.3 nTPM (vital, limit 1)",,45,not_established,not_triggered,,,ELSPBP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"retina: 72.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169402,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,3.6,1.2,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,RSPH10B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,False,False,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169495,False,excluded,rna_above_tissue_ceiling,True,0,5,partial,6.8,2.2,"bone marrow: 6.8 nTPM (vital, limit 5)",,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HTRA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"bone marrow: 6.8 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000169551,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,CT55,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025,True,True,,,,unchanged
ENSG00000169570,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,10,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); thyroid gland: 8.7 nTPM (protected, limit 5); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 5); liver: 4.3 nTPM (vital, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,DTWD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 10 nTPM (vital, limit 2); thyroid gland: 8.7 nTPM (protected, limit 5); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 5); liver: 4.3 nTPM (vital, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169575,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,29.4,0.5,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,VPREB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169594,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,14.6,"adipose tissue: 14.6 nTPM (protected, limit 5); esophagus: 12.2 nTPM (protected, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,BNC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adipose tissue: 14.6 nTPM (protected, limit 5); esophagus: 12.2 nTPM (protected, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169607,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,13,4.9,"bone marrow: 13 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,CKAP2L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 13 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000169621,False,excluded,rna_above_tissue_ceiling,True,0,0,routine_complete,1.5,1.4,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,APLF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169679,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.7,15.6,"lymph node: 15.6 nTPM (protected, limit 5); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,BUB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"lymph node: 15.6 nTPM (protected, limit 5); bone marrow: 11.7 nTPM (vital, limit 1); appendix: 8.1 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169684,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,4.6,4.1,"duodenum: 4.6 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CHRNA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 4.6 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000169717,False,excluded,positive_ihc_outside_permitted,True,0,7,partial,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),43,not_established,not_triggered,,,ACTRT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000169760,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,12.3,2.2,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),42,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,NLGN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000169777,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,not_triggered,,,TAS2R1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000169800,True,compatible,,True,0,2,partial,0,0,,,45,not_established,not_triggered,,,RBMY1F,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000169918,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12,1.3,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OTUD7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000169953,True,compatible,,True,0,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,HSFY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000170100,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,4.9,7.8,"parathyroid gland: 7.8 nTPM (protected, limit 5); pancreas: 4.9 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF778,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 7.8 nTPM (protected, limit 5); pancreas: 4.9 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000170160,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,12.5,2.2,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC144A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000170236,True,compatible,,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,USP50,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000170264,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,28.1,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM161A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000170279,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.3,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,C7orf33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000170469,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,22.2,18.4,"skeletal muscle: 22.2 nTPM (vital, limit 5); heart muscle: 19.9 nTPM (vital, limit 5); tongue: 18.4 nTPM (protected, limit 5); kidney: 14.4 nTPM (vital, limit 5); pituitary gland: 12.3 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 5); adrenal gland: 6.9 nTPM (vital, limit 5); retina: 6.3 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 5); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 5); spinal cord: 4.2 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPATA24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 22.2 nTPM (vital, limit 5); heart muscle: 19.9 nTPM (vital, limit 5); tongue: 18.4 nTPM (protected, limit 5); kidney: 14.4 nTPM (vital, limit 5); pituitary gland: 12.3 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 5); adrenal gland: 6.9 nTPM (vital, limit 5); retina: 6.3 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 5); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 5); spinal cord: 4.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000170486,True,compatible,,True,0,6,partial,2.1,2.8,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,KRT72,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000170498,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,4.4,2.1,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen; thymus,KISS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000170516,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,COX7B2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000170613,True,compatible,,True,0,5,partial,0,0,,,45,not_established,not_triggered,,,GARIN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000170627,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,6,5.5,"bone marrow: 6 nTPM (vital, limit 2); lymph node: 5.5 nTPM (protected, limit 5)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GTSF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 6 nTPM (vital, limit 2); lymph node: 5.5 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000170703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,4.7,3.6,"choroid plexus: 4.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; thymus,TTLL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 4.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000170734,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,8.2,12.6,"lymph node: 12.6 nTPM (protected, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); thyroid gland: 6.6 nTPM (protected, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); pancreas: 5.2 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,POLH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 12.6 nTPM (protected, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 5); appendix: 6.7 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); thyroid gland: 6.6 nTPM (protected, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); pancreas: 5.2 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000170748,True,compatible,,True,0,2,partial,0.1,0,,,47,not_established,not_triggered,,,RBMXL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000170777,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TPD52L3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000170782,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR10A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000170788,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,DYDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000170820,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; thymus,FSHR,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000170848,True,compatible,,True,0,2,partial,1.4,0,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,PSG6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000170873,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,70.7,43.7,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 5); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); pancreas: 27.6 nTPM (vital, limit 1); tongue: 23.7 nTPM (protected, limit 5); adipose tissue: 23.7 nTPM (protected, limit 5); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 5); urinary bladder: 15 nTPM (protected, limit 5); retina: 14.6 nTPM (vital, limit 1); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MTSS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 5); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (protected, limit 5); tongue: 23.7 nTPM (protected, limit 5); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 5); urinary bladder: 15 nTPM (protected, limit 5); retina: 14.6 nTPM (vital, limit 1); appendix: 12.8 nTPM (protected, limit 5); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 5); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); gallbladder: 8.9 nTPM (protected, limit 5); rectum: 8.8 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000170903,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,32.1,16.1,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (protected, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 5); lung: 8.2 nTPM (vital, limit 1); adipose tissue: 8 nTPM (protected, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 5); esophagus: 7.7 nTPM (protected, limit 5); choroid plexus: 7.4 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); colon: 6.9 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,MSANTD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (protected, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 5); lung: 8.2 nTPM (vital, limit 1); adipose tissue: 8 nTPM (protected, limit 5); appendix: 8 nTPM (protected, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 5); esophagus: 7.7 nTPM (protected, limit 5); choroid plexus: 7.4 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); colon: 6.9 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 2); gallbladder: 6.3 nTPM (protected, limit 5); rectum: 6.1 nTPM (protected, limit 5); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000170925,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TEX13B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000170946,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,16.4,10.9,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); lymph node: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); esophagus: 5.1 nTPM (protected, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,DNAJC24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); lymph node: 6.6 nTPM (protected, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); appendix: 5.2 nTPM (protected, limit 5); esophagus: 5.1 nTPM (protected, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 2); small intestine: 4.3 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000170948,False,excluded,positive_ihc_outside_permitted,True,0,7,partial,0.7,0,,kidney / proximal tubules (cell body): Medium (Supported),50,not_established,not_triggered,,,MBD3L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,kidney / proximal tubules (cell body): Medium (Supported),positive_ihc_outside_permitted,unchanged
ENSG00000170950,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,PGK2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000170953,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR8B12,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000170965,True,compatible,,True,0,2,partial,0.1,0.1,,,46,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PLAC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Wang 2016;Bradley 2020;Gong 2021,True,True,,,,unchanged
ENSG00000170967,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,DDI1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000171060,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C8orf74,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000171094,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,1.7,0.6,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,ALK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000171102,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,OBP2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000171121,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,7.6,4.7,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,KCNMB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000171133,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.8,0,,,0,not_established,not_triggered,,,OR2K2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000171209,True,compatible,,True,0,2,partial,0.1,0.2,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; thymus; tonsil,CSN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000171320,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.7,4.5,"duodenum: 10.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ESCO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 10.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171402,True,compatible,,True,0,0,routine_complete,1.9,3,,,47,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,XAGE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000171405,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,XAGE5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000171478,True,compatible,existing_nomination_or_manual_review,True,0,1,partial,0.3,0.2,,,46,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,SPACA5B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000171481,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,OR1L3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000171487,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,0,21.7,"parathyroid gland: 21.7 nTPM (protected, limit 5)",,0,not_established,not_triggered,,,NLRP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"parathyroid gland: 21.7 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000171489,True,compatible,,True,0,1,partial,0.4,0.5,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus,SPACA5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000171492,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,42.5,24.3,"spinal cord: 42.5 nTPM (vital, limit 1); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 5); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 5); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (protected, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 5); parathyroid gland: 7.4 nTPM (protected, limit 5); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRRC8D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 42.5 nTPM (vital, limit 1); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 5); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 5); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (protected, limit 5); appendix: 15.3 nTPM (protected, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 5); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 5); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); gallbladder: 7.8 nTPM (protected, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 5); parathyroid gland: 7.4 nTPM (protected, limit 5); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000171495,True,compatible,,True,0,1,partial,0,0.1,,,48,not_established,not_triggered,,,MROH2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000171505,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,OR1N1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000171533,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,17,partial,93.1,22.2,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 5); parathyroid gland: 21.3 nTPM (protected, limit 10); adrenal gland: 18.4 nTPM (vital, limit 5); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 5); stomach: 10.3 nTPM (protected, limit 10); heart muscle: 8.3 nTPM (vital, limit 5); lung: 7.5 nTPM (vital, limit 5); small intestine: 4.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,MAP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 5); parathyroid gland: 21.3 nTPM (protected, limit 10); adrenal gland: 18.4 nTPM (vital, limit 5); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 5); stomach: 10.3 nTPM (protected, limit 10); heart muscle: 8.3 nTPM (vital, limit 5); lung: 7.5 nTPM (vital, limit 5); small intestine: 4.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000171540,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,3,partial,12.9,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),49,not_established,not_triggered,,,OTP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000171722,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,SPATA46,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171757,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,5.6,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,LRRC34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000171772,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,17.5,1.8,"cerebellum: 17.5 nTPM (vital, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 5); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebellum: 17.5 nTPM (vital, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 5); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171790,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.9,"lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,SLFNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171794,True,compatible,,True,0,6,partial,0.1,0,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,UTF1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000171804,True,compatible,,True,0,80,unavailable,0.1,0.3,,,0,not_established,not_triggered,,,WDR87,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000171827,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,3.4,3.9,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF570,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000171847,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.8,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM90A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171864,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,39.4,1.9,"choroid plexus: 39.4 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,PRND,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 39.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171872,True,compatible,,True,0,2,partial,1.1,1,,,45,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,KLF17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000171931,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,FBXW10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,False,False,"cerebellum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000171956,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,4.1,0.2,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,FOXB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000171988,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,38.3,20.7,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 5); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 5); thyroid gland: 19.1 nTPM (protected, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (protected, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 5); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 5); tongue: 12.4 nTPM (protected, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 5); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,JMJD1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); gallbladder: 22.7 nTPM (protected, limit 5); lymph node: 20.7 nTPM (protected, limit 5); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 5); thyroid gland: 19.1 nTPM (protected, limit 5); appendix: 17.6 nTPM (protected, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (protected, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 5); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 5); tongue: 12.4 nTPM (protected, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 5); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000171989,True,compatible,,True,0,1,partial,0.3,0.3,,,48,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,LDHAL6B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000172073,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,TEX37,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000172139,True,compatible,,True,0,80,unavailable,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,SLC9C1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000172244,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,1.1,2.7,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C5orf34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000172288,True,compatible,existing_nomination_or_manual_review,True,0,3,partial,0,0,,,43,not_established,not_triggered,,,CDY1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000172320,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,OR5A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000172352,True,compatible,existing_nomination_or_manual_review,True,0,3,partial,0,0,,,43,not_established,not_triggered,,,CDY1B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000172361,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,19.9,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP53,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000172362,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5B12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000172365,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.2,0.1,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,OR5B2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000172421,True,compatible,,True,0,2,partial,0.2,0.4,,,45,not_established,not_triggered,,,EFCAB3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000172465,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,91.4,94.7,"urinary bladder: 94.7 nTPM (protected, limit 5); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 5); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 5); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 5); adipose tissue: 33.8 nTPM (protected, limit 5); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 5); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (protected, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 5); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); rectum: 16.2 nTPM (protected, limit 5); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TCEAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"urinary bladder: 94.7 nTPM (protected, limit 5); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 5); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 5); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 5); adipose tissue: 33.8 nTPM (protected, limit 5); gallbladder: 33.6 nTPM (protected, limit 5); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 5); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (protected, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 5); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); rectum: 16.2 nTPM (protected, limit 5); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 5); appendix: 13.4 nTPM (protected, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000172468,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.7,0.1,,,0,not_established,not_triggered,,,HSFY1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000172519,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.6,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,OR10H5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000172538,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FAM170B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000172671,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,6.6,4.8,"cerebellum: 6.6 nTPM (vital, limit 5); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZFAND4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 6.6 nTPM (vital, limit 5); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000172680,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,MOS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000172717,True,compatible,,True,0,80,unavailable,0.8,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; thymus; tonsil,GARIN2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000172733,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,11.5,0.3,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,PURG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000172738,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,2.1,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TMEM217,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000172771,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.5,1.6,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EFCAB12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000172785,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,39,37.5,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 5); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 5); thyroid gland: 25.1 nTPM (protected, limit 5); urinary bladder: 23.6 nTPM (protected, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 5); adipose tissue: 18.4 nTPM (protected, limit 5); tongue: 17.6 nTPM (protected, limit 5); colon: 16.4 nTPM (protected, limit 5); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 5); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); midbrain: 13.4 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNG1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 5); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 5); thyroid gland: 25.1 nTPM (protected, limit 5); urinary bladder: 23.6 nTPM (protected, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 5); adipose tissue: 18.4 nTPM (protected, limit 5); tongue: 17.6 nTPM (protected, limit 5); colon: 16.4 nTPM (protected, limit 5); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); appendix: 15.4 nTPM (protected, limit 5); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 5); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); midbrain: 13.4 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1); gallbladder: 10.4 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000172840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,8.9,9,"thyroid gland: 9 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); adipose tissue: 5.8 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PDP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 9 nTPM (protected, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); adipose tissue: 5.8 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000172967,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,XKR3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173093,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,0,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CCDC63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173157,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,ADAMTS20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000173213,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,9,3,partial,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TUBB8B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,False,False,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,unchanged
ENSG00000173258,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.3,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (protected, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF483,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (protected, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173261,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,0.4,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus,PLAC8L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173262,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,6.4,1.5,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLC2A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,False,False,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000173335,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CST9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000173389,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IQCF1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173401,True,compatible,,True,0,2,partial,0.4,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,GLIPR1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173421,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.4,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IHO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173431,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,RNASE8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000173451,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,25.2,27.2,"urinary bladder: 27.2 nTPM (protected, limit 5); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (protected, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 5); esophagus: 6.4 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 2); stomach: 6.2 nTPM (protected, limit 5); spinal cord: 5.6 nTPM (vital, limit 1); duodenum: 5.5 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); tongue: 5.4 nTPM (protected, limit 5); kidney: 5.4 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,THAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"urinary bladder: 27.2 nTPM (protected, limit 5); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (protected, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); appendix: 8.9 nTPM (protected, limit 5); gallbladder: 8.3 nTPM (protected, limit 5); lymph node: 7.7 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 5); stomach: 6.2 nTPM (protected, limit 5); spinal cord: 5.6 nTPM (vital, limit 1); duodenum: 5.5 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); tongue: 5.4 nTPM (protected, limit 5); kidney: 5.4 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000173464,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,RNASE11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173557,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,8.5,4.6,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,45,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,CIMIP2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173611,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,7.2,2.8,"retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,SCAI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000173621,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,40.1,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); adipose tissue: 14.8 nTPM (protected, limit 10); colon: 14.4 nTPM (protected, limit 10); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 5); heart muscle: 11.9 nTPM (vital, limit 5); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 5); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 5); stomach: 8.1 nTPM (protected, limit 5); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 5)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,LRFN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); adipose tissue: 14.8 nTPM (protected, limit 10); colon: 14.4 nTPM (protected, limit 10); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 5); heart muscle: 11.9 nTPM (vital, limit 5); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 5); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 5); stomach: 8.1 nTPM (protected, limit 5); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 5)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000173627,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.1,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,APOBEC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173673,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,HES3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000173699,True,compatible,,True,0,1,partial,0.3,0.1,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,SPATA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173714,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1135.6,1,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus,WFIKKN2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000173728,True,compatible,,True,0,80,unavailable,0,0.5,,,0,not_established,not_triggered,,,SPMIP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000173769,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TOPAZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000173809,True,compatible,,True,0,80,unavailable,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TDRD12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000173818,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,25.5,10.6,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 5); hypothalamus: 10.5 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); stomach: 9.2 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 5); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (protected, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 5); tongue: 5.3 nTPM (protected, limit 5); lymph node: 5.1 nTPM (protected, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENDOV,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 5); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (protected, limit 5); stomach: 9.2 nTPM (protected, limit 5); urinary bladder: 9 nTPM (protected, limit 5); pituitary gland: 9 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); thyroid gland: 8.9 nTPM (protected, limit 5); small intestine: 8.9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); gallbladder: 6.2 nTPM (protected, limit 5); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 5); appendix: 5.3 nTPM (protected, limit 5); tongue: 5.3 nTPM (protected, limit 5); lymph node: 5.1 nTPM (protected, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173838,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,17.8,1,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,MARCHF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173868,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,18.7,3.1,"bone marrow: 18.7 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PHOSPHO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 18.7 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173889,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,50.3,17.6,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 5); thyroid gland: 16.1 nTPM (protected, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 5); tongue: 13.4 nTPM (protected, limit 5); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 5); stomach: 11.5 nTPM (protected, limit 5); urinary bladder: 11.4 nTPM (protected, limit 5); duodenum: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 5); pancreas: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 5); lung: 9.4 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PHC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 5); thyroid gland: 16.1 nTPM (protected, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 5); tongue: 13.4 nTPM (protected, limit 5); smooth muscle: 12.9 nTPM (vital, limit 1); gallbladder: 12.4 nTPM (protected, limit 5); appendix: 12.3 nTPM (protected, limit 5); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 5); stomach: 11.5 nTPM (protected, limit 5); urinary bladder: 11.4 nTPM (protected, limit 5); pancreas: 10.9 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 5); colon: 10.1 nTPM (protected, limit 5); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); skeletal muscle: 8.4 nTPM (vital, limit 1); liver: 8.4 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000173894,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,2.2,4.1,"bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CBX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000173908,True,compatible,,True,0,5,partial,0,0.3,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,KRT28,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000173930,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,40.1,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SLCO4C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000173933,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,129.5,97.5,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); esophagus: 97.5 nTPM (protected, limit 5); stomach: 95.5 nTPM (protected, limit 5); lymph node: 95.2 nTPM (protected, limit 5); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 5); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (protected, limit 5); urinary bladder: 81.5 nTPM (protected, limit 5); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (protected, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 5); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 5); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 5); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); esophagus: 97.5 nTPM (protected, limit 5); stomach: 95.5 nTPM (protected, limit 5); lymph node: 95.2 nTPM (protected, limit 5); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 5); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (protected, limit 5); urinary bladder: 81.5 nTPM (protected, limit 5); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (protected, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 5); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 5); appendix: 68.6 nTPM (protected, limit 5); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 5); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); gallbladder: 56.2 nTPM (protected, limit 5); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000173988,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,0.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,LRRC63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174007,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,6.4,3.2,"cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,CEP19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000174015,True,compatible,,True,0,1,partial,0.1,0.1,,,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CBY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000174016,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TENT5D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000174038,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,0.8,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C9orf131,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,False,False,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174206,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,8.3,5.5,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); thyroid gland: 5.4 nTPM (protected, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,KICS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); thyroid gland: 5.4 nTPM (protected, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000174225,True,compatible,,True,0,80,unavailable,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ARL13A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Gong 2021;Carter 2023,True,True,,,,unchanged
ENSG00000174279,True,compatible,,True,0,80,unavailable,0,0.9,,,0,not_established,not_triggered,,,EVX2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000174371,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.1,5.7,"bone marrow: 17.1 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 5); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EXO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 17.1 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 5); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174405,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,25.4,11.1,"retina: 25.4 nTPM (vital, limit 1); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); lymph node: 11 nTPM (protected, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (protected, limit 5); midbrain: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); pituitary gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); lung: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 5); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); colon: 5.6 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LIG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 25.4 nTPM (vital, limit 1); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 5); lymph node: 11 nTPM (protected, limit 5); appendix: 8.6 nTPM (protected, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (protected, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (protected, limit 5); lung: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 5); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); gallbladder: 6.7 nTPM (protected, limit 5); smooth muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); amygdala: 6.5 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); colon: 5.6 nTPM (protected, limit 5); pancreas: 5.1 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000174446,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,58,31.8,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 5); colon: 31.7 nTPM (protected, limit 5); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 5); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 5); thyroid gland: 26.1 nTPM (protected, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 5); stomach: 22.5 nTPM (protected, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (protected, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 5); esophagus: 15.3 nTPM (protected, limit 5); duodenum: 15.2 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SNAPC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 5); colon: 31.7 nTPM (protected, limit 5); retina: 27.6 nTPM (vital, limit 1); pituitary gland: 26.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 5); urinary bladder: 26.5 nTPM (protected, limit 5); thyroid gland: 26.1 nTPM (protected, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 5); stomach: 22.5 nTPM (protected, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (protected, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 5); appendix: 16.8 nTPM (protected, limit 5); esophagus: 15.3 nTPM (protected, limit 5); duodenum: 15.2 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); gallbladder: 13.4 nTPM (protected, limit 5)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000174448,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,STARD6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000174450,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,GOLGA6L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,False,False,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174483,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,24.2,36.7,"parathyroid gland: 36.7 nTPM (protected, limit 5); thyroid gland: 26.4 nTPM (protected, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); pituitary gland: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); hypothalamus: 16.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 5); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 5); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (protected, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); tongue: 7.9 nTPM (protected, limit 5); skeletal muscle: 7.8 nTPM (vital, limit 1); rectum: 7.1 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,BBS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 36.7 nTPM (protected, limit 5); thyroid gland: 26.4 nTPM (protected, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 5); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 5); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 5); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); gallbladder: 12.1 nTPM (protected, limit 5); adipose tissue: 10.2 nTPM (protected, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 5); tongue: 7.9 nTPM (protected, limit 5); skeletal muscle: 7.8 nTPM (vital, limit 1); rectum: 7.1 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000174527,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,MYO1H,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000174562,True,compatible,,True,0,0,routine_complete,0.8,2.2,,,48,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,KLK15,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000174667,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.3,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,OR7D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000174776,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.1,0.9,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,WDR49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174788,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,116.2,5.5,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (protected, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174796,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21,15.4,"retina: 21 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); thyroid gland: 15 nTPM (protected, limit 5); skeletal muscle: 15 nTPM (vital, limit 1); heart muscle: 14 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); small intestine: 12.7 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 5); rectum: 11.4 nTPM (protected, limit 5); cerebellum: 11.4 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 5); smooth muscle: 10.3 nTPM (vital, limit 1); kidney: 9.6 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); adipose tissue: 9.6 nTPM (protected, limit 5); esophagus: 9.4 nTPM (protected, limit 5); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 5); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,THAP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 21 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); thyroid gland: 15 nTPM (protected, limit 5); skeletal muscle: 15 nTPM (vital, limit 1); heart muscle: 14 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); small intestine: 12.7 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); appendix: 12.2 nTPM (protected, limit 5); liver: 12.1 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 5); rectum: 11.4 nTPM (protected, limit 5); cerebellum: 11.4 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 5); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); kidney: 9.6 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); esophagus: 9.4 nTPM (protected, limit 5); pituitary gland: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 5); gallbladder: 8.7 nTPM (protected, limit 5); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174886,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,664.8,317.1,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 5); colon: 301.7 nTPM (protected, limit 5); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 5); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 5); urinary bladder: 202.5 nTPM (protected, limit 5); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (protected, limit 5); thyroid gland: 183.2 nTPM (protected, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 5); parathyroid gland: 133.6 nTPM (protected, limit 5); duodenum: 121.1 nTPM (vital, limit 1); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 5); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NDUFA11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 5); colon: 301.7 nTPM (protected, limit 5); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 5); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 5); urinary bladder: 202.5 nTPM (protected, limit 5); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (protected, limit 5); thyroid gland: 183.2 nTPM (protected, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 5); parathyroid gland: 133.6 nTPM (protected, limit 5); duodenum: 121.1 nTPM (vital, limit 1); gallbladder: 102.9 nTPM (protected, limit 5); appendix: 90.7 nTPM (protected, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 5); retina: 30.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000174898,True,compatible,,True,0,6,partial,0,0,,,43,not_established,not_triggered,,,CATSPERD,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000175018,True,compatible,,True,0,80,unavailable,0.4,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TEX36,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000175073,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,20,8.3,"bone marrow: 20 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 5); skeletal muscle: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 5); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,VCPIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 20 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 5); liver: 6.8 nTPM (vital, limit 1); appendix: 5.8 nTPM (protected, limit 5); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 5); skeletal muscle: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 5); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000175097,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,23,"thyroid gland: 23 nTPM (protected, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus; tonsil,RAG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 23 nTPM (protected, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000175106,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,10.7,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TVP23C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 5); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000175175,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,21.6,0.4,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,PPM1E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000175202,True,compatible,,True,0,80,unavailable,0,0.2,,,0,not_established,not_triggered,,,HIGD2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,True,True,,,,unchanged
ENSG00000175294,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,CATSPER1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000175305,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,36.5,10.6,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 5); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); retina: 5 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCNE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); appendix: 6.7 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 5); retina: 5 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000175344,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,9.4,6.4,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CHRNA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); appendix / endocrine cells: Medium (Enhanced); appendix / enterocytes: Medium (Enhanced); appendix / goblet cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175449,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,17.6,2.8,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RFESD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175513,True,compatible,,True,0,80,unavailable,0.7,0.2,,,0,not_established,not_triggered,,,TSGA10IP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000175518,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,1,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,UBQLNL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"kidney: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000175520,True,compatible,,True,0,1,partial,0,0,,,47,not_established,not_triggered,,,UBQLN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000175536,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,9,partial,7.8,6.8,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 5); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LIPT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 5); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175548,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,8.8,4.5,"retina: 8.8 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ALG10B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.8 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175646,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,5.6,4.2,"skeletal muscle: 5.6 nTPM (vital, limit 5); pituitary gland: 1.9 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,PRM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"skeletal muscle: 5.6 nTPM (vital, limit 5); pituitary gland: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000175664,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.6,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,TEX26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000175699,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,1,0.6,,,0,not_established,not_triggered,,,CCDC197,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000175718,True,compatible,,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,RBMXL3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000175764,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,26.5,9.9,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 5); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 5); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,TTLL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 5); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 5); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 5); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175787,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,5.9,5.8,"cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 5); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 5); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000175809,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CBLL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000175820,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CCDC168,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000175877,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,TMEM270,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000176020,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,1,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,AMIGO3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176040,True,compatible,,True,0,80,unavailable,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; thymus,TMPRSS7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000176083,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,4.6,3.3,"lung: 4.6 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF683,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,False,False,"lung: 4.6 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000176148,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,10,partial,12.2,7,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (protected, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 2); liver: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),40,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TCP11L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); gallbladder: 7.8 nTPM (protected, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 5); colon: 6.7 nTPM (protected, limit 5); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (protected, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); pancreas: 5.5 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 2); liver: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); gallbladder / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000176160,True,compatible,,True,0,2,partial,0.4,1.1,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,HSF5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000176165,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,20.6,0.5,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus,FOXG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176177,True,compatible,,True,0,80,unavailable,0.9,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENTHD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000176198,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR11H4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000176208,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.2,3.5,"bone marrow: 12.2 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ATAD5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 12.2 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176219,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR11H6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000176256,True,compatible,,True,0,4,partial,0.1,0,,,46,not_established,not_triggered,,,HMGB4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000176294,True,compatible,,True,0,80,unavailable,0.5,0.5,,,0,not_established,not_triggered,,,OR4N2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000176299,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4M1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000176302,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,FOXR1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000176401,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,15.9,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,EID2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000176563,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,3.2,"kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,CNTD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176566,True,compatible,,True,0,1,partial,0,0,,,45,not_established,not_triggered,,,DCAF4L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000176571,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,CNBD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000176597,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,75.7,36.3,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 5); urinary bladder: 23.3 nTPM (protected, limit 5); colon: 21.9 nTPM (protected, limit 5); rectum: 19 nTPM (protected, limit 5); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (protected, limit 5); stomach: 11 nTPM (protected, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,B3GNT5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 5); urinary bladder: 23.3 nTPM (protected, limit 5); colon: 21.9 nTPM (protected, limit 5); gallbladder: 20.6 nTPM (protected, limit 5); rectum: 19 nTPM (protected, limit 5); lung: 14.5 nTPM (vital, limit 1); appendix: 13.4 nTPM (protected, limit 5); adipose tissue: 11.5 nTPM (protected, limit 5); stomach: 11 nTPM (protected, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000176635,True,compatible,,True,0,4,partial,2.8,0.1,,,45,not_established,not_triggered,,,HORMAD2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000176679,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TGIF2LY,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000176732,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PFN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176746,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,3,unreliable,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),50,not_established,not_triggered,,,MAGEB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,False,False,,kidney / proximal tubules (microvilli): Medium (Enhanced),positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000176771,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.1,3.8,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NCKAP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176774,True,compatible,,True,0,3,partial,0,0,,,45,not_established,not_triggered,,,MAGEB18,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000176782,True,compatible,existing_nomination_or_manual_review,True,0,2,partial,0,1.6,,,46,not_established,not_triggered,,,DEFB104A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000176787,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000176895,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR51A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000176922,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR51S1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000176927,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,EFCAB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000176979,True,compatible,,True,0,2,partial,0,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TRIM60,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000176988,True,compatible,,True,0,1,partial,0.1,0,,,47,not_established,not_triggered,,,FMR1NB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000177023,True,compatible,existing_nomination_or_manual_review,True,0,0,routine_complete,0,0.2,,,48,not_established,not_triggered,,,DEFB104B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000177025,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,15.6,1.9,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C19orf18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000177058,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,16.1,10.9,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 5); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); colon: 9.1 nTPM (protected, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); esophagus: 8.1 nTPM (protected, limit 5); urinary bladder: 8.1 nTPM (protected, limit 5); stomach: 7.9 nTPM (protected, limit 5); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (protected, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (protected, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),40,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,SLC38A9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Bruggeman 2018;Bradley 2020,False,False,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 5); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); colon: 9.1 nTPM (protected, limit 5); appendix: 8.6 nTPM (protected, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 5); esophagus: 8.1 nTPM (protected, limit 5); gallbladder: 8 nTPM (protected, limit 5); stomach: 7.9 nTPM (protected, limit 5); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (protected, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (protected, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000177138,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,0.2,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,FAM9B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"liver: 3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000177143,True,compatible,,True,0,2,partial,0,0,,,46,not_established,not_triggered,,,CETN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177202,True,compatible,,True,0,1,partial,3,3.5,,,47,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,SPACA4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000177272,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,2.1,0.6,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,KCNA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000177294,True,compatible,,True,0,80,unavailable,0.8,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,FBXO39,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000177324,True,compatible,,True,0,2,partial,0.2,0,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,BEND2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177398,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus,UMODL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000177414,True,compatible,,True,0,80,unavailable,0.8,2.3,,,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,UBE2U,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000177483,True,compatible,,True,0,5,partial,0.5,0.3,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,RBM44,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000177504,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0,0,,adrenal gland / glandular cells: Low (Enhanced),47,not_established,not_triggered,,,VCX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,,adrenal gland / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000177558,True,compatible,,True,0,2,partial,0.1,0,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,FAM187B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177627,True,compatible,,True,0,80,unavailable,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,C12orf54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177673,True,compatible,,True,0,1,partial,0,0,,,47,not_established,not_triggered,,,TEX44,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000177684,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB114,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000177689,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,MAGEB10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,True,True,,,,unchanged
ENSG00000177692,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,2.8,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DNAJC28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000177694,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,3.4,9.9,"parathyroid gland: 9.9 nTPM (protected, limit 5); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,NAALADL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 9.9 nTPM (protected, limit 5); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); appendix / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); gallbladder / glandular cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000177839,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,4.2,1.1,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PCDHB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000177842,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.1,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF620,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000177873,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,4,3,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF619,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000177910,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025;da Silva 2017,False,False,,,incomplete_routine_rna,unchanged
ENSG00000177938,True,compatible,,True,0,1,partial,1.2,1.2,,,48,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,CAPZA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177947,True,compatible,,True,0,3,partial,0.4,0,,,45,not_established,not_triggered,,,ODF3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000177992,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,SPATA31E1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000177994,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,CIMIP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178021,True,compatible,,True,0,1,partial,0.1,0,,,48,not_established,not_triggered,,,TSPYL6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000178053,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,175.9,103.1,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 5); tongue: 103.1 nTPM (protected, limit 5); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 5); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 10); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 5); midbrain: 16.6 nTPM (vital, limit 1); thyroid gland: 16 nTPM (protected, limit 10); cerebral cortex: 15.8 nTPM (vital, limit 5); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 5); urinary bladder: 13.6 nTPM (protected, limit 10); adipose tissue: 10.5 nTPM (protected, limit 10); colon: 9.6 nTPM (protected, limit 5); pancreas: 9.3 nTPM (vital, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 5)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MLF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 5); tongue: 103.1 nTPM (protected, limit 5); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 5); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 10); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 5); midbrain: 16.6 nTPM (vital, limit 1); thyroid gland: 16 nTPM (protected, limit 10); cerebral cortex: 15.8 nTPM (vital, limit 5); spinal cord: 15.3 nTPM (vital, limit 1); gallbladder: 14.6 nTPM (protected, limit 10); smooth muscle: 13.6 nTPM (vital, limit 5); urinary bladder: 13.6 nTPM (protected, limit 10); adipose tissue: 10.5 nTPM (protected, limit 10); colon: 9.6 nTPM (protected, limit 5); pancreas: 9.3 nTPM (vital, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 5)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000178093,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.9,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,TSSK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178125,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,PPP1R42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178177,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,6.8,4.4,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,LCORL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178229,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,2.9,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF543,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178257,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,0.3,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,PRM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178279,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TNP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000178287,True,compatible,,True,0,3,partial,0,0.1,,,45,not_established,not_triggered,,,SPAG11A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000178295,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,15,10.5,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 5); liver: 8.4 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); esophagus: 5.4 nTPM (protected, limit 5); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GEN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 5); liver: 8.4 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 5); esophagus: 5.4 nTPM (protected, limit 5); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178297,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,0.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,TMPRSS9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178385,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,8.1,3.9,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PLEKHM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178386,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,5.1,6.2,"thyroid gland: 6.2 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZNF223,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 6.2 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000178395,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CCDC185,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000178403,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,NEUROG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178404,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.7,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus,CEP295NL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178409,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,1.5,1.9,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BEND3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178460,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.8,2.7,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MCMDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178502,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,8.9,4.4,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,KLHL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178573,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,80.7,49.2,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); parathyroid gland: 49.2 nTPM (protected, limit 5); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 5); adipose tissue: 26.9 nTPM (protected, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (protected, limit 5); esophagus: 22 nTPM (protected, limit 5); tongue: 19 nTPM (protected, limit 5); lung: 18.2 nTPM (vital, limit 1); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 5); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 5); spinal cord: 11.8 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 5); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MAF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); parathyroid gland: 49.2 nTPM (protected, limit 5); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 5); adipose tissue: 26.9 nTPM (protected, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (protected, limit 5); esophagus: 22 nTPM (protected, limit 5); appendix: 20.1 nTPM (protected, limit 5); tongue: 19 nTPM (protected, limit 5); lung: 18.2 nTPM (vital, limit 1); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 5); gallbladder: 16.1 nTPM (protected, limit 5); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 5); spinal cord: 11.8 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 5); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 5); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000178591,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB125,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000178645,True,compatible,,True,0,1,partial,0.3,0,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,C10orf53,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000178665,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF713,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178694,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,3.8,"bone marrow: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NSUN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178795,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,0,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,GDPD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178796,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,33.8,1,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 5); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),75,not_established,not_triggered,,,RIIAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 5); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000178804,False,excluded,positive_ihc_outside_permitted;family_exclusion,True,0,3,partial,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),45,not_established,not_triggered,,,H1-8,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,cerebellum / cells in molecular layer: Low (Enhanced),positive_ihc_outside_permitted;family_exclusion,unchanged
ENSG00000178852,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.2,13.6,"thyroid gland: 13.6 nTPM (protected, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EFCAB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 13.6 nTPM (protected, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178928,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,TPRX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000178997,True,compatible,,True,0,80,unavailable,0.4,0.2,,,0,not_established,not_triggered,,,EXD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000179008,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.7,3.5,"pituitary gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; thymus,C14orf39,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179046,True,compatible,,True,0,80,unavailable,0.4,0.1,,,0,not_established,not_triggered,,,TRIML2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000179055,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR13D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000179059,True,compatible,,True,0,80,unavailable,0.7,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZFP42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,True,True,,,,unchanged
ENSG00000179071,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,1.6,1.2,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCDC89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000179083,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.7,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,FAM133A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179088,True,compatible,,True,0,80,unavailable,0.4,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,C12orf42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,True,True,,,,unchanged
ENSG00000179133,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,5.5,0.5,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,C10orf67,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000179142,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,0,routine_complete,173.3,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CYP11B2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000179165,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,PXT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000179168,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.8,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,GGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179172,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,HNRNPCL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000179213,True,compatible,,True,0,4,partial,0,0,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,SIGLECL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000179295,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,12,partial,94.8,60.5,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 5); adipose tissue: 56 nTPM (protected, limit 5); parathyroid gland: 51 nTPM (protected, limit 5); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (protected, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 5); esophagus: 37.2 nTPM (protected, limit 5); kidney: 36.1 nTPM (vital, limit 1); lymph node: 31.8 nTPM (protected, limit 5); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 5); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 5); stomach: 28.1 nTPM (protected, limit 5); duodenum: 26 nTPM (vital, limit 1); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),40,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PTPN11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 5); adipose tissue: 56 nTPM (protected, limit 5); parathyroid gland: 51 nTPM (protected, limit 5); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (protected, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 5); esophagus: 37.2 nTPM (protected, limit 5); kidney: 36.1 nTPM (vital, limit 1); lymph node: 31.8 nTPM (protected, limit 5); lung: 31.7 nTPM (vital, limit 1); appendix: 31.6 nTPM (protected, limit 5); colon: 31.4 nTPM (protected, limit 5); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 5); stomach: 28.1 nTPM (protected, limit 5); gallbladder: 27.3 nTPM (protected, limit 5); duodenum: 26 nTPM (vital, limit 1); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000179299,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,9.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NSUN7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000179363,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1.3,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,TMEM31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179397,True,compatible,,True,0,80,unavailable,1,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CATSPERE,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000179407,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DNAJB8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000179412,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,HNRNPCL4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000179468,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,OR9A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000179580,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,RNF151,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000179598,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,11,partial,21.6,8.7,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 5); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,PLD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 5); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000179600,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GPHB5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000179603,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21,1.9,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,GRM8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179636,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,12.8,4.5,"liver: 12.8 nTPM (vital, limit 5); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,TPPP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"liver: 12.8 nTPM (vital, limit 5); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000179695,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR6C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000179709,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,NLRP8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000179751,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,27446.4,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,SYCN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000179796,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,24.5,4.6,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; thymus,LRRC3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000179817,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MRGPRX4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000179869,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,44.1,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ABCA13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000179873,True,compatible,,True,0,80,unavailable,1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,NLRP11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,True,True,,,,unchanged
ENSG00000179919,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR10A7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000179988,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,6.1,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PSTK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000180016,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0.1,,,0,not_established,not_triggered,,,OR1E1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000180043,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GARIN5B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000180083,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,0.3,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,WFDC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180090,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,OR3A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000180113,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,10.6,5.5,"cerebellum: 10.6 nTPM (vital, limit 5); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,TDRD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 10.6 nTPM (vital, limit 5); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180116,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,REDIC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000180138,True,compatible,,True,0,80,unavailable,0.5,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,CSNK1A1L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000180185,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,17,partial,71.2,26.8,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 5); tongue: 26.8 nTPM (protected, limit 5); colon: 22.5 nTPM (protected, limit 5); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 5); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 5); rectum: 16.2 nTPM (protected, limit 5); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 5); hypothalamus: 12.9 nTPM (vital, limit 1); adipose tissue: 12.2 nTPM (protected, limit 10); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 5); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (protected, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,FAHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 5); tongue: 26.8 nTPM (protected, limit 5); colon: 22.5 nTPM (protected, limit 5); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 5); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 5); rectum: 16.2 nTPM (protected, limit 5); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); gallbladder: 13.6 nTPM (protected, limit 5); parathyroid gland: 13.5 nTPM (protected, limit 5); hypothalamus: 12.9 nTPM (vital, limit 1); adipose tissue: 12.2 nTPM (protected, limit 10); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 5); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (protected, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); appendix: 8.4 nTPM (protected, limit 5); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); appendix / endocrine cells: High (Enhanced); appendix / enterocytes: High (Enhanced); appendix / germinal center cells: Low (Enhanced); appendix / goblet cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000180205,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,WFDC9,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000180219,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GARIN6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000180269,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,GPR139,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000180305,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,not_triggered,,,WFDC10A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000180336,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.3,0.4,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,MEIOC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,False,False,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180423,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,5.4,3.9,"bone marrow: 5.4 nTPM (vital, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); kidney: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); heart muscle: 2.4 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,HARBI1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.4 nTPM (vital, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); kidney: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); heart muscle: 2.4 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000180424,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,DEFB123,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000180425,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,21.6,14.6,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 5); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (protected, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); heart muscle: 9 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 5); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); lymph node: 6.5 nTPM (protected, limit 5); rectum: 6 nTPM (protected, limit 5); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (protected, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C11orf71,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 5); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (protected, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); heart muscle: 9 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 5); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); lymph node: 6.5 nTPM (protected, limit 5); rectum: 6 nTPM (protected, limit 5); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (protected, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180479,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,28,75.2,"thyroid gland: 75.2 nTPM (protected, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 5); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF571,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 75.2 nTPM (protected, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 5); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180481,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,6.4,3.9,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,GLIPR1L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000180483,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,150.8,0.1,"retina: 150.8 nTPM (vital, limit 1)",,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,DEFB119,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,False,False,"retina: 150.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180592,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SKIDA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180628,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,27.3,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (protected, limit 5); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); duodenum: 17.1 nTPM (vital, limit 1); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 5); tongue: 16 nTPM (protected, limit 5); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 5); rectum: 13.7 nTPM (protected, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (protected, limit 5); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 5); urinary bladder: 11.8 nTPM (protected, limit 5); smooth muscle: 11.5 nTPM (vital, limit 2); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,PCGF5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (protected, limit 5); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); duodenum: 17.1 nTPM (vital, limit 1); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 5); tongue: 16 nTPM (protected, limit 5); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 5); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 5); rectum: 13.7 nTPM (protected, limit 5); adipose tissue: 13.2 nTPM (protected, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); appendix: 12.7 nTPM (protected, limit 5); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 5); gallbladder: 12.2 nTPM (protected, limit 5); urinary bladder: 11.8 nTPM (protected, limit 5); smooth muscle: 11.5 nTPM (vital, limit 2); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000180658,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,OR2A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000180697,True,compatible,,True,0,5,partial,0,0,,,46,not_established,not_triggered,,,C3orf22,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000180776,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,32.6,38,"stomach: 38 nTPM (protected, limit 5); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 5); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 5); colon: 16.2 nTPM (protected, limit 5); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (protected, limit 5); rectum: 15.2 nTPM (protected, limit 5); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZDHHC20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"stomach: 38 nTPM (protected, limit 5); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 5); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 5); appendix: 16.8 nTPM (protected, limit 5); colon: 16.2 nTPM (protected, limit 5); gallbladder: 16.2 nTPM (protected, limit 5); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (protected, limit 5); rectum: 15.2 nTPM (protected, limit 5); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (protected, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000180872,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB112,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000180878,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.4,0.3,"retina: 1.4 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,C11orf42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000180934,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,OR56A1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000180938,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ZNF572,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000180974,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,OR52E4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000180999,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.8,3.2,"heart muscle: 16.8 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus,C1orf105,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"heart muscle: 16.8 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000181029,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,108.4,83.2,"skeletal muscle: 108.4 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 5); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); adipose tissue: 57.1 nTPM (protected, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 5); thyroid gland: 54.3 nTPM (protected, limit 5); urinary bladder: 53.7 nTPM (protected, limit 5); colon: 51.4 nTPM (protected, limit 5); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 5); lymph node: 22.8 nTPM (protected, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TRAPPC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 5); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); adipose tissue: 57.1 nTPM (protected, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 5); thyroid gland: 54.3 nTPM (protected, limit 5); urinary bladder: 53.7 nTPM (protected, limit 5); colon: 51.4 nTPM (protected, limit 5); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 5); appendix: 24.9 nTPM (protected, limit 5); lymph node: 22.8 nTPM (protected, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 5); gallbladder: 13.3 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 5)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000181195,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,738.6,22.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 5); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 5); colon: 22.3 nTPM (protected, limit 5); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 5); tongue: 5.1 nTPM (protected, limit 5); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PENK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 5); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 5); colon: 22.3 nTPM (protected, limit 5); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); gallbladder: 12.1 nTPM (protected, limit 10); cerebral cortex: 7.2 nTPM (vital, limit 5); tongue: 5.1 nTPM (protected, limit 5); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000181322,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,20.1,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NME9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000181323,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,SPEM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000181371,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5M8,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000181433,True,compatible,,True,0,6,partial,0.2,0,,,44,not_established,not_triggered,,,SAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000181450,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.7,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF678,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000181552,True,compatible,,True,0,0,routine_complete,0,0,,,47,not_established,not_triggered,,,EDDM3B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000181562,True,compatible,,True,0,5,partial,0.7,0,,,46,not_established,not_triggered,,,EDDM3A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000181609,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000181616,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52H1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000181626,True,compatible,,True,0,3,partial,0.9,0.2,,,46,not_established,not_triggered,,,ANKRD62,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,True,True,,,,unchanged
ENSG00000181722,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,8.6,8.6,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZBTB20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 5); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000181781,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8,0.3,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,CIMAP1D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"skeletal muscle: 8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000181786,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ACTL9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000181827,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,8.8,5.6,"retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 5); lymph node: 5.5 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RFX7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 5); lymph node: 5.5 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000181867,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FTMT,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000181873,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,5.8,3.8,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,IBA57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000181896,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13.4,26.8,"lymph node: 26.8 nTPM (protected, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF101,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 26.8 nTPM (protected, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); appendix: 12.6 nTPM (protected, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 5); urinary bladder: 5.4 nTPM (protected, limit 5); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000181904,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,41.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (protected, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 5); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 5); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (protected, limit 5); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 5); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 5); esophagus: 20.3 nTPM (protected, limit 5); hippocampal formation: 20.3 nTPM (vital, limit 1); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); midbrain: 18.1 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 5); small intestine: 16.7 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); stomach: 15.7 nTPM (protected, limit 5); pituitary gland: 15 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C5orf24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (protected, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 5); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 5); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (protected, limit 5); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 5); skeletal muscle: 20.7 nTPM (vital, limit 1); gallbladder: 20.6 nTPM (protected, limit 5); colon: 20.5 nTPM (protected, limit 5); esophagus: 20.3 nTPM (protected, limit 5); hippocampal formation: 20.3 nTPM (vital, limit 1); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); midbrain: 18.1 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 5); appendix: 17.3 nTPM (protected, limit 5); small intestine: 16.7 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); stomach: 15.7 nTPM (protected, limit 5); pituitary gland: 15 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000181961,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4A16,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000181965,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.7,0,,,0,not_established,not_triggered,,,NEUROG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000182035,True,compatible,,True,0,80,unavailable,0.3,1,,,0,not_established,not_triggered,,,ADIG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000182050,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,4.4,5.8,"thyroid gland: 5.8 nTPM (protected, limit 5); basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),43,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,MGAT4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 5.8 nTPM (protected, limit 5); basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000182053,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM49B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000182083,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,OR6B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000182111,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,ZNF716,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Wang 2016;Bruggeman 2018,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000182134,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,13.1,29.1,"parathyroid gland: 29.1 nTPM (protected, limit 5); cerebellum: 13.1 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TDRKH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 29.1 nTPM (protected, limit 5); cerebellum: 13.1 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (protected, limit 5); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000182170,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MRGPRG,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000182185,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,7.3,4.7,"bone marrow: 7.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAD51B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 7.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000182223,True,compatible,,True,0,80,unavailable,0.7,0,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ZAR1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000182256,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,26.3,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,GABRG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000182261,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,0.2,0,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NLRP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000182264,True,compatible,,True,0,1,partial,1.5,0.9,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,IZUMO1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000182308,True,compatible,,True,0,2,partial,1.1,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,DCAF4L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000182315,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,MBD3L3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000182324,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,56.9,1.2,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KCNJ14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000182405,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.1,2,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PGBD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000182459,True,compatible,,True,0,2,partial,0,0,,,45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,TEX19,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000182481,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,11,partial,98,70.4,"bone marrow: 98 nTPM (vital, limit 1); lymph node: 70.4 nTPM (protected, limit 5); esophagus: 40.2 nTPM (protected, limit 5); urinary bladder: 37.2 nTPM (protected, limit 5); rectum: 34.7 nTPM (protected, limit 5); smooth muscle: 33.3 nTPM (vital, limit 5); colon: 29.7 nTPM (protected, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); adipose tissue: 25 nTPM (protected, limit 10); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 5); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (protected, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 5); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KPNA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 98 nTPM (vital, limit 1); lymph node: 70.4 nTPM (protected, limit 5); appendix: 44 nTPM (protected, limit 5); esophagus: 40.2 nTPM (protected, limit 5); urinary bladder: 37.2 nTPM (protected, limit 5); rectum: 34.7 nTPM (protected, limit 5); smooth muscle: 33.3 nTPM (vital, limit 5); colon: 29.7 nTPM (protected, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); adipose tissue: 25 nTPM (protected, limit 10); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); gallbladder: 18.8 nTPM (protected, limit 5); stomach: 18.5 nTPM (protected, limit 5); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 5); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (protected, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 5); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000182583,True,compatible,,True,0,7,partial,0.4,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,VCX,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000182613,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,OR2V2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000182645,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,0.1,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CCDC172,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"retina: 3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000182652,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4Q3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000182752,True,compatible,,True,0,2,partial,4,8.8,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PAPPA,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,True,True,,,,unchanged
ENSG00000182791,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,1.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; thymus,CCDC87,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000182793,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GSTA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000182798,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.9,0.4,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,MAGEB17,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000182890,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,3.8,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GLUD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000182896,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TMEM95,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000182898,True,compatible,,True,0,1,partial,0,0,,,46,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,TCHHL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000182901,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,43.6,0.9,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 5); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,RGS7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 5); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000182950,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CIMAP1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000182968,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,5.4,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SOX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000182974,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4M2B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000182993,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.2,1.8,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C12orf60,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183024,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR1G1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000183034,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,19.4,"colon: 19.4 nTPM (protected, limit 5); rectum: 10.3 nTPM (protected, limit 5); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,OTOP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"colon: 19.4 nTPM (protected, limit 5); rectum: 10.3 nTPM (protected, limit 5); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183035,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,CYLC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183066,True,compatible,,True,0,3,partial,0.7,0.6,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,WBP2NL,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000183137,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,11.2,16.3,"parathyroid gland: 16.3 nTPM (protected, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 5); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (protected, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1); thyroid gland: 8.4 nTPM (protected, limit 5); colon: 8.2 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); pancreas: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); esophagus: 6 nTPM (protected, limit 5); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CEP57L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 16.3 nTPM (protected, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 5); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (protected, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); gallbladder: 9.1 nTPM (protected, limit 5); lymph node: 8.6 nTPM (protected, limit 5); duodenum: 8.4 nTPM (vital, limit 1); thyroid gland: 8.4 nTPM (protected, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 5); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); appendix: 7.6 nTPM (protected, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); esophagus: 6 nTPM (protected, limit 5); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000183166,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,56.6,0.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,CALN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000183185,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,8.5,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,GABRR3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 8.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000183206,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000183246,True,compatible,,True,0,7,partial,0,0,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; thymus,RIMBP3C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183269,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52E8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000183304,True,compatible,,True,0,80,unavailable,0.8,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,FAM9A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183305,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEA2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000183313,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000183318,True,compatible,,True,0,3,partial,0.8,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,SPDYE4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183324,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.5,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,REC114,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"heart muscle: 4.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183396,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,0.6,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,TMEM89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183434,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TFDP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000183476,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,2.3,1.7,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),66,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,SH2D7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",appendix / endocrine cells: High (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183496,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,4,3.3,"hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MEX3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183559,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,C10orf120,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183629,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GOLGA8G,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000183632,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,TP53TG3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000183640,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0.6,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP8-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000183654,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.7,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,MARCHF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,False,False,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183668,True,compatible,,True,0,1,partial,0.7,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,PSG9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000183706,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4N4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000183753,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,BPY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000183795,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.2,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,BPY2B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000183808,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,10.2,7.9,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); thyroid gland: 6.5 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,RBM12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 5); thyroid gland: 6.5 nTPM (protected, limit 5); appendix: 5.7 nTPM (protected, limit 5); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183831,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,6.2,9,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen; thymus,ANKRD45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183833,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,15.8,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,4.5,6.5,"colon: 6.5 nTPM (protected, limit 5); stomach: 5.9 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,GPR39,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"colon: 6.5 nTPM (protected, limit 5); stomach: 5.9 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183850,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,1.8,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF730,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000183862,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CNGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000183914,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,20.1,10.2,"retina: 20.1 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 10); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 20.1 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 10); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000183977,True,compatible,,True,0,4,partial,1.9,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,PP2D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000184032,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP20-2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000184033,True,compatible,,True,0,3,partial,0.2,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,CTAG1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000184108,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIML1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184148,False,excluded,positive_ihc_outside_permitted,True,0,5,partial,0.1,1.1,,esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,SPRR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000184166,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,2.3,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OR1D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000184302,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,0,routine_complete,27.7,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),57,not_established,not_triggered,,,SIX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000184305,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,3.3,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,CCSER1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000184330,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,0,5.5,"esophagus: 5.5 nTPM (protected, limit 5)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported),44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,S100A7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 5.5 nTPM (protected, limit 5)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000184345,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IQCF2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184361,True,compatible,,True,0,1,partial,0.5,0.3,,,47,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,SPATA32,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184368,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,31.3,8.5,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 5); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,MAP7D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 5); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000184378,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,2.7,1.6,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACTRT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000184459,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; thymus; tonsil,BPIFC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000184478,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR56A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000184502,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,55.5,9294.1,"stomach: 9294.1 nTPM (protected, limit 5); duodenum: 55.5 nTPM (vital, limit 5)",stomach 2 / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen; thymus,GAST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"stomach: 9294.1 nTPM (protected, limit 5); duodenum: 55.5 nTPM (vital, limit 5)",stomach 2 / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000184507,True,compatible,,True,0,5,partial,0.2,0.1,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,NUTM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184560,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,SPEM2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184571,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,PIWIL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000184599,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,44.5,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),48,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,TAFA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000184602,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,168.2,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (protected, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 5); lymph node: 30.1 nTPM (protected, limit 5); adrenal gland: 28.6 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 5); urinary bladder: 17.8 nTPM (protected, limit 5); thyroid gland: 16.7 nTPM (protected, limit 5); colon: 16.3 nTPM (protected, limit 5); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); small intestine: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 5); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 5); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SNN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (protected, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 5); lymph node: 30.1 nTPM (protected, limit 5); adrenal gland: 28.6 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); gallbladder: 21.3 nTPM (protected, limit 5); lung: 20.9 nTPM (vital, limit 1); appendix: 19.3 nTPM (protected, limit 5); esophagus: 18.5 nTPM (protected, limit 5); urinary bladder: 17.8 nTPM (protected, limit 5); thyroid gland: 16.7 nTPM (protected, limit 5); colon: 16.3 nTPM (protected, limit 5); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); small intestine: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 5); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 5); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 5)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000184635,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,6.7,"thyroid gland: 6.7 nTPM (protected, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 6.7 nTPM (protected, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000184647,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,PRSS55,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184650,True,compatible,,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,ODF4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184661,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,6.4,5.1,"bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CDCA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",appendix / endocrine cells: High (Enhanced); appendix / enterocytes: Medium (Enhanced); appendix / germinal center cells: Low (Enhanced); appendix / goblet cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000184675,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,3.9,14.7,"tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,AMER1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000184716,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,14.9,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,SERINC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000184724,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP6-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000184735,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DDX53,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000184786,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,DYNLT2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,True,True,,,,unchanged
ENSG00000184814,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR23B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000184911,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,28.2,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DMRTC1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000184933,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR6A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000185002,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,2,partial,4.4,6.3,"stomach: 6.3 nTPM (protected, limit 5); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),46,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,RFX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"stomach: 6.3 nTPM (protected, limit 5); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000185013,True,compatible,,True,0,80,unavailable,0.7,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,NT5C1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185046,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,68.2,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 5); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 5); skeletal muscle: 15.8 nTPM (vital, limit 5); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANKS1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 5); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 5); skeletal muscle: 15.8 nTPM (vital, limit 5); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185055,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.4,0.8,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EFCAB10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185056,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,C5orf47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185104,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,11.8,9,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,FAF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 5); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 5); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185156,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.1,4,"pancreas: 9.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,MFSD6L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 9.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185177,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ZNF479,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185236,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,163.8,203.6,"thyroid gland: 203.6 nTPM (protected, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 5); pituitary gland: 112.7 nTPM (vital, limit 1); adipose tissue: 98.8 nTPM (protected, limit 5); urinary bladder: 96.2 nTPM (protected, limit 5); colon: 95.8 nTPM (protected, limit 5); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 5); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 5); parathyroid gland: 47.2 nTPM (protected, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 5); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RAB11B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 203.6 nTPM (protected, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 5); pituitary gland: 112.7 nTPM (vital, limit 1); adipose tissue: 98.8 nTPM (protected, limit 5); urinary bladder: 96.2 nTPM (protected, limit 5); colon: 95.8 nTPM (protected, limit 5); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 5); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); appendix: 57.4 nTPM (protected, limit 5); lymph node: 57.3 nTPM (protected, limit 5); gallbladder: 49.4 nTPM (protected, limit 5); parathyroid gland: 47.2 nTPM (protected, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 5); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000185245,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,4.9,14.3,"lymph node: 14.3 nTPM (protected, limit 7.5); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,GP1BA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 14.3 nTPM (protected, limit 7.5); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185247,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0.1,,,0,not_established,not_triggered,,,MAGEA11,current_adaptive,False,True,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000185261,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,3.2,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,KIAA0825,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185264,True,compatible,,True,0,1,partial,0.1,0,,,47,not_established,not_triggered,,,TEX33,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185269,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.7,2,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,NOTUM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185278,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,10.2,3.4,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZBTB37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185290,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17.7,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (protected, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 5); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NUPR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (protected, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 5); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185294,True,compatible,,True,0,5,partial,1.7,0,,,42,not_established,not_triggered,,,SPPL2C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185306,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,2.4,0.9,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; thymus,C12orf56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185313,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,SCN10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000185352,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,16.7,2.6,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,HS6ST3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185414,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,28.5,20.2,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 5); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 5); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); spinal cord: 12.1 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); colon: 9.5 nTPM (protected, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 5); small intestine: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.1 nTPM (protected, limit 5); pituitary gland: 7 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MRPL30,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 5); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 5); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); spinal cord: 12.1 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (protected, limit 5); colon: 9.5 nTPM (protected, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 5); small intestine: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.1 nTPM (protected, limit 5); pituitary gland: 7 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185448,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FAM47A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185480,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,9.2,4.1,"bone marrow: 9.2 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,PARPBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 9.2 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185523,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,0.8,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,SPATA45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pancreas: 2.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185634,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15.4,2.7,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SHC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185658,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,52.8,23.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 5); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (protected, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); urinary bladder: 12 nTPM (protected, limit 5); rectum: 11.9 nTPM (protected, limit 5); stomach: 11.8 nTPM (protected, limit 5); esophagus: 11.6 nTPM (protected, limit 5); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BRWD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 5); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 5); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (protected, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 5); colon: 12.1 nTPM (protected, limit 5); urinary bladder: 12 nTPM (protected, limit 5); rectum: 11.9 nTPM (protected, limit 5); stomach: 11.8 nTPM (protected, limit 5); esophagus: 11.6 nTPM (protected, limit 5); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); gallbladder: 10.6 nTPM (protected, limit 5); appendix: 9.9 nTPM (protected, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185662,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,SMIM23,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185666,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,5.1,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185670,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,3,4.8,"retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZBTB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185686,True,compatible,,True,0,3,partial,3.6,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRAME,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000185697,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,5.7,19.7,"lymph node: 19.7 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,MYBL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"lymph node: 19.7 nTPM (protected, limit 5); appendix: 5.9 nTPM (protected, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185730,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.9,4.2,"duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF696,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185775,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31A6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185792,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,2,unreliable,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,NLRP9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000185798,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,14.5,12.1,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 5); choroid plexus: 11.5 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 5); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 5); esophagus: 8.7 nTPM (protected, limit 5); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); colon: 7.8 nTPM (protected, limit 5); heart muscle: 7.8 nTPM (vital, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (protected, limit 5); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); urinary bladder: 7 nTPM (protected, limit 5); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); basal ganglia: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,WDR53,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 5); choroid plexus: 11.5 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 5); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 5); esophagus: 8.7 nTPM (protected, limit 5); retina: 8.6 nTPM (vital, limit 1); kidney: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (protected, limit 5); adrenal gland: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); urinary bladder: 7 nTPM (protected, limit 5); cerebellum: 7 nTPM (vital, limit 2); stomach: 7 nTPM (protected, limit 5); thyroid gland: 6.9 nTPM (protected, limit 5); rectum: 6.9 nTPM (protected, limit 5); basal ganglia: 6.8 nTPM (vital, limit 1); appendix: 6.7 nTPM (protected, limit 5); spinal cord: 6.7 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); gallbladder: 6.1 nTPM (protected, limit 5); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185823,True,compatible,,True,0,80,unavailable,0.8,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,NPAP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000185829,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,33.6,21.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 5); tongue: 19.8 nTPM (protected, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 5); thyroid gland: 18 nTPM (protected, limit 5); bone marrow: 18 nTPM (vital, limit 1); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 5); stomach: 10.3 nTPM (protected, limit 5); esophagus: 9.8 nTPM (protected, limit 5); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ARL17A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 5); tongue: 19.8 nTPM (protected, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 5); thyroid gland: 18 nTPM (protected, limit 5); bone marrow: 18 nTPM (vital, limit 1); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 5); appendix: 11.8 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 5); stomach: 10.3 nTPM (protected, limit 5); esophagus: 9.8 nTPM (protected, limit 5); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); gallbladder: 8 nTPM (protected, limit 5); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185842,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,6.4,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DNAH14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000185863,True,compatible,,True,0,1,partial,0.2,0.1,,,48,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,TMEM210,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000185883,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,589.8,327.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 5); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (protected, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 5); colon: 167 nTPM (protected, limit 5); thyroid gland: 161.7 nTPM (protected, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 5); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 5); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 5); lymph node: 49.6 nTPM (protected, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ATP6V0C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 5); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (protected, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 5); colon: 167 nTPM (protected, limit 5); thyroid gland: 161.7 nTPM (protected, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 5); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 5); appendix: 92.6 nTPM (protected, limit 5); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 5); lymph node: 49.6 nTPM (protected, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 5); gallbladder: 22.4 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000185888,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRSS38,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000185894,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.2,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,BPY2C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000185920,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,14.4,16.2,"stomach: 16.2 nTPM (protected, limit 5); rectum: 16 nTPM (protected, limit 5); colon: 14.9 nTPM (protected, limit 5); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); tongue: 6.2 nTPM (protected, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PTCH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"stomach: 16.2 nTPM (protected, limit 5); rectum: 16 nTPM (protected, limit 5); colon: 14.9 nTPM (protected, limit 5); small intestine: 14.4 nTPM (vital, limit 1); gallbladder: 11.2 nTPM (protected, limit 5); duodenum: 9.3 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (protected, limit 5); urinary bladder: 6.2 nTPM (protected, limit 5); tongue: 6.2 nTPM (protected, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000185955,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,9.1,1.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SPACDR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185958,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.2,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,FAM186A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185972,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,CCIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000185982,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB128,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000186007,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,0.9,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,LEMD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186026,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1.6,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF284,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186075,True,compatible,,True,0,1,partial,0.5,0.7,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZPBP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000186086,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,0.3,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,NBPF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"liver: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186103,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ARGFX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000186118,True,compatible,,True,0,80,unavailable,0.8,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus,TEX38,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000186143,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000186150,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.2,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,46,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,UBL4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186190,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus,BPIFB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000186230,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.9,1.7,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF749,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186280,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,2,0.9,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,KDM4D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000186300,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.4,4.5,"retina: 5.4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF555,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 5.4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186334,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SLC36A3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000186393,True,compatible,,True,0,6,partial,0.9,0.1,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,KRT26,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000186446,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,1.8,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF501,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186451,True,compatible,,True,0,3,partial,0.3,0.3,,,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,SPATA12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000186452,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TMPRSS12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000186453,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM228A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186469,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,83.4,44,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); bone marrow: 57.1 nTPM (vital, limit 1); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (protected, limit 5); lymph node: 40.3 nTPM (protected, limit 5); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 5); urinary bladder: 19.9 nTPM (protected, limit 5); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 5); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 5); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 5); esophagus: 11.9 nTPM (protected, limit 5); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,GNG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); bone marrow: 57.1 nTPM (vital, limit 1); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (protected, limit 5); lymph node: 40.3 nTPM (protected, limit 5); appendix: 35.3 nTPM (protected, limit 5); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 5); urinary bladder: 19.9 nTPM (protected, limit 5); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 5); pituitary gland: 14.5 nTPM (vital, limit 1); gallbladder: 14.3 nTPM (protected, limit 5); stomach: 13.8 nTPM (protected, limit 5); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 5); esophagus: 11.9 nTPM (protected, limit 5); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000186471,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,75.1,0.1,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),59,not_established,not_triggered,,,AKAP14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000186487,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,39.4,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,MYT1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186513,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR9Q2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000186562,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,DEFB105A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000186572,True,compatible,existing_nomination_or_manual_review,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,DEFB107A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000186579,True,compatible,existing_nomination_or_manual_review,True,0,0,routine_complete,0,0.1,,,48,not_established,not_triggered,,,DEFB106A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000186583,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.4,0.6,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,SPATC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,False,False,"bone marrow: 8.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186599,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB105B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000186638,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.5,1.5,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KIF24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,False,False,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186645,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,9,3,partial,0,0,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),46,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,SPDYE17,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000186714,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,CCDC73,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000186788,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31D3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000186790,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.7,0.1,,,0,not_established,not_triggered,,,FOXE3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000186812,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,24.1,15.7,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 5); thyroid gland: 15.3 nTPM (protected, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 5); rectum: 13.4 nTPM (protected, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); hippocampal formation: 12.9 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (protected, limit 5); colon: 12.4 nTPM (protected, limit 5); small intestine: 12.2 nTPM (vital, limit 1); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 5); basal ganglia: 11.3 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 5); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF397,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 5); thyroid gland: 15.3 nTPM (protected, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 5); appendix: 13.9 nTPM (protected, limit 5); rectum: 13.4 nTPM (protected, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 5); hippocampal formation: 12.9 nTPM (vital, limit 1); colon: 12.4 nTPM (protected, limit 5); adipose tissue: 12.4 nTPM (protected, limit 5); small intestine: 12.2 nTPM (vital, limit 1); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 5); basal ganglia: 11.3 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 5); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); gallbladder: 9.7 nTPM (protected, limit 5); esophagus: 9.5 nTPM (protected, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000186871,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,3.2,2.3,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ERCC6L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000186897,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,C1QL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186918,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,46,46.3,"esophagus: 46.3 nTPM (protected, limit 5); pancreas: 46 nTPM (vital, limit 1); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (protected, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 5); urinary bladder: 25.4 nTPM (protected, limit 5); colon: 24.8 nTPM (protected, limit 5); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); lymph node: 20.8 nTPM (protected, limit 5); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thyroid gland: 18 nTPM (protected, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 5); pituitary gland: 16 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 5); tongue: 13.4 nTPM (protected, limit 5); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZNF395,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 46.3 nTPM (protected, limit 5); pancreas: 46 nTPM (vital, limit 1); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (protected, limit 5); heart muscle: 26.3 nTPM (vital, limit 1); retina: 26.3 nTPM (vital, limit 1); urinary bladder: 25.4 nTPM (protected, limit 5); stomach: 25.4 nTPM (protected, limit 5); colon: 24.8 nTPM (protected, limit 5); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); lymph node: 20.8 nTPM (protected, limit 5); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thyroid gland: 18 nTPM (protected, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 5); pituitary gland: 16 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); gallbladder: 14 nTPM (protected, limit 5); appendix: 13.9 nTPM (protected, limit 5); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 5); tongue: 13.4 nTPM (protected, limit 5); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000186952,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.5,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TMEM232,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000186976,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EFCAB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187003,True,compatible,,True,0,4,partial,0,0,,,46,not_established,not_triggered,,,ACTL7A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187005,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP21-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000187017,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,125.7,33.3,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 5); bone marrow: 27.6 nTPM (vital, limit 5); colon: 27.3 nTPM (protected, limit 5); parathyroid gland: 26 nTPM (protected, limit 5); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ESPN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 5); bone marrow: 27.6 nTPM (vital, limit 5); colon: 27.3 nTPM (protected, limit 5); parathyroid gland: 26 nTPM (protected, limit 5); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000187024,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,26,19.5,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (protected, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (protected, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 5); urinary bladder: 12.5 nTPM (protected, limit 5); lung: 12.3 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 5); esophagus: 10.1 nTPM (protected, limit 5); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PTRH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (protected, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (protected, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 5); urinary bladder: 12.5 nTPM (protected, limit 5); lung: 12.3 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 5); esophagus: 10.1 nTPM (protected, limit 5); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000187026,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP21-2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000187033,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,130,0.2,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,SAMD7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 130 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000187066,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TMEM262,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000187080,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,OR2AK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000187082,True,compatible,existing_nomination_or_manual_review,True,0,5,partial,0,0,,,45,not_established,not_triggered,,,DEFB106B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000187105,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,2.8,1.5,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,HEATR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000187122,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,33.9,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,SLIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187144,True,compatible,,True,0,80,unavailable,0.8,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,SPATA21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000187166,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,8,partial,0.7,0.4,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),41,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H1-7,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000187186,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,95.6,21.6,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 5); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 5); cerebellum: 33 nTPM (vital, limit 5); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 5); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 5); kidney: 14.2 nTPM (vital, limit 5); thyroid gland: 13.2 nTPM (protected, limit 10); adrenal gland: 9.4 nTPM (vital, limit 5); pancreas: 8.5 nTPM (vital, limit 5); liver: 6.6 nTPM (vital, limit 5); retina: 6.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187186,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 5); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 5); cerebellum: 33 nTPM (vital, limit 5); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 5); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 5); kidney: 14.2 nTPM (vital, limit 5); thyroid gland: 13.2 nTPM (protected, limit 10); adrenal gland: 9.4 nTPM (vital, limit 5); pancreas: 8.5 nTPM (vital, limit 5); liver: 6.6 nTPM (vital, limit 5); retina: 6.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187187,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,2.3,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF546,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187191,True,compatible,,True,0,1,partial,0,0.6,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,DAZ3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187223,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,0,"skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; thymus; tonsil,LCE2D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"skeletal muscle: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187268,True,compatible,,True,0,80,unavailable,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,FAM9C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,True,True,,,,unchanged
ENSG00000187372,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,1.1,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187475,True,compatible,family_exclusion,True,0,1,partial,0.1,0,,,47,not_established,required,in_situ_inflammation_review,appendix,H1-6,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,True,,,family_exclusion,unchanged
ENSG00000187479,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,366,462.7,"adipose tissue: 462.7 nTPM (protected, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 5); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 5); colon: 145.8 nTPM (protected, limit 5); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (protected, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 5); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 5); rectum: 8.1 nTPM (protected, limit 5); lymph node: 6.6 nTPM (protected, limit 5); bone marrow: 4.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,C11orf96,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"adipose tissue: 462.7 nTPM (protected, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 5); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 5); colon: 145.8 nTPM (protected, limit 5); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (protected, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); gallbladder: 59 nTPM (protected, limit 5); pancreas: 58.8 nTPM (vital, limit 1); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 5); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); appendix: 38.1 nTPM (protected, limit 5); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 5); rectum: 8.1 nTPM (protected, limit 5); lymph node: 6.6 nTPM (protected, limit 5); bone marrow: 4.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000187516,True,compatible,,True,0,1,partial,0.1,0,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,H2AP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187533,True,compatible,,True,0,2,partial,1.1,0.1,,,47,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,PRR27,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000187537,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000187569,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,DPPA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000187581,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,0.4,0.1,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,COX8C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000187607,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,15,13.9,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (protected, limit 5); esophagus: 9.7 nTPM (protected, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 5); lymph node: 8.6 nTPM (protected, limit 5); urinary bladder: 8.6 nTPM (protected, limit 5); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); stomach: 5.1 nTPM (protected, limit 5); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF286A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (protected, limit 5); esophagus: 9.7 nTPM (protected, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 5); gallbladder: 8.7 nTPM (protected, limit 5); urinary bladder: 8.6 nTPM (protected, limit 5); lymph node: 8.6 nTPM (protected, limit 5); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); appendix: 6.4 nTPM (protected, limit 5); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (protected, limit 5); stomach: 5.1 nTPM (protected, limit 5); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187624,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,9.8,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (protected, limit 5); hippocampal formation: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LIAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (protected, limit 5); hippocampal formation: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000187658,True,compatible,,True,0,80,unavailable,0.7,1.7,,,0,not_established,not_triggered,,,C5orf52,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187690,True,compatible,,True,0,2,partial,1.6,0.1,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,EZHIP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000187726,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,26.1,2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,DNAJB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000187736,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,16.5,13.6,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 5); adipose tissue: 9.9 nTPM (protected, limit 5); stomach: 8.7 nTPM (protected, limit 5); rectum: 8.7 nTPM (protected, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 5); duodenum: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NHEJ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 5); adipose tissue: 9.9 nTPM (protected, limit 5); stomach: 8.7 nTPM (protected, limit 5); rectum: 8.7 nTPM (protected, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 5); duodenum: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 5); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000187741,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.3,7.7,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 5); esophagus: 6.4 nTPM (protected, limit 5); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FANCA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 5); esophagus: 6.4 nTPM (protected, limit 5); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187753,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,0.5,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,C9orf153,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"bone marrow: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187754,True,compatible,,True,0,2,partial,0.6,0.3,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SSX7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000187772,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,1.5,0.1,"retina: 1.5 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,LIN28B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187775,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,2.4,0,"retina: 2.4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,DNAH17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187790,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,1.8,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FANCM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187791,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.7,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,SPATA31F3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000187792,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,2.1,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF70,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187806,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TMEM202,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187815,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.9,2.8,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZFP69,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187833,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C2orf78,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187860,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC157,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000187918,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR51I2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000187969,True,compatible,,True,0,5,partial,0,0,,,46,not_established,not_triggered,,,ZCCHC13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000187987,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,1.2,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZSCAN23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Low (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188032,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,C19orf67,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000188033,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,2.2,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF490,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188050,True,compatible,,True,0,80,unavailable,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,RNF133,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188092,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12,6.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); adipose tissue: 5.9 nTPM (protected, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 5); basal ganglia: 5 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GPR89B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 5); urinary bladder: 6.1 nTPM (protected, limit 5); adipose tissue: 5.9 nTPM (protected, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 5); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 5); basal ganglia: 5 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188120,True,compatible,,True,0,1,partial,0,0.2,,,48,not_established,not_triggered,,,DAZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188155,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP10-6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000188162,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,1.3,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,OTOG,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000188163,True,compatible,,True,0,3,partial,1.8,0.6,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,CIMIP2A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188167,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,5.4,1.8,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TMPPE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188171,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,10.4,21.7,"thyroid gland: 21.7 nTPM (protected, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 5); urinary bladder: 13.8 nTPM (protected, limit 5); lymph node: 11.8 nTPM (protected, limit 5); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); stomach: 7.8 nTPM (protected, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); pancreas: 6.8 nTPM (vital, limit 1); esophagus: 6 nTPM (protected, limit 5); tongue: 5.6 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ZNF626,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 21.7 nTPM (protected, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 5); urinary bladder: 13.8 nTPM (protected, limit 5); lymph node: 11.8 nTPM (protected, limit 5); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); smooth muscle: 8.8 nTPM (vital, limit 1); gallbladder: 8.8 nTPM (protected, limit 5); adrenal gland: 8.5 nTPM (vital, limit 1); stomach: 7.8 nTPM (protected, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (protected, limit 5); pancreas: 6.8 nTPM (vital, limit 1); esophagus: 6 nTPM (protected, limit 5); tongue: 5.6 nTPM (protected, limit 5); liver: 5.3 nTPM (vital, limit 1); appendix: 5.2 nTPM (protected, limit 5); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188295,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.5,5.3,"bone marrow: 11.5 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF669,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.5 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188306,True,compatible,,True,0,80,unavailable,0.4,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,LRRIQ4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000188312,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,12.1,5.5,"bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); lymph node: 5.5 nTPM (protected, limit 5); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,CENPP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); lymph node: 5.5 nTPM (protected, limit 5); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188321,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,25.2,21.5,"pituitary gland: 25.2 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 5); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 5); colon: 16.1 nTPM (protected, limit 5); lymph node: 15.6 nTPM (protected, limit 5); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (protected, limit 5); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); hypothalamus: 11 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 5); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF559,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pituitary gland: 25.2 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 5); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); heart muscle: 19.1 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (protected, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 5); colon: 16.1 nTPM (protected, limit 5); lymph node: 15.6 nTPM (protected, limit 5); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (protected, limit 5); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 5); lung: 12.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); hypothalamus: 11 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 5); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); gallbladder: 9.5 nTPM (protected, limit 5); appendix: 8.9 nTPM (protected, limit 5); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 5); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188334,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,7.3,0,"retina: 7.3 nTPM (vital, limit 1)",,46,not_established,not_triggered,,,BSPH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 7.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188368,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.1,1.1,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRR19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188386,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PPP3R2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188394,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.6,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,GPR21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000188408,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000188425,True,compatible,,True,0,5,partial,0.1,0,,,46,not_established,not_triggered,,,NANOS2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188467,True,compatible,,True,0,80,unavailable,0.6,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,SLC24A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000188558,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,OR2G6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000188585,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.8,1.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,CLEC20A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000188687,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,42.7,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (protected, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 5); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SLC4A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (protected, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 5); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000188691,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR56A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000188738,True,compatible,,True,0,80,unavailable,0.6,2.5,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; thymus,FSIP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,True,True,,,,unchanged
ENSG00000188739,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,35,22.6,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 5); skeletal muscle: 19 nTPM (vital, limit 1); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (protected, limit 5); urinary bladder: 15.1 nTPM (protected, limit 5); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 5); rectum: 13.6 nTPM (protected, limit 5); esophagus: 13.4 nTPM (protected, limit 5); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (protected, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBM34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 5); skeletal muscle: 19 nTPM (vital, limit 1); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (protected, limit 5); urinary bladder: 15.1 nTPM (protected, limit 5); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); appendix: 14.5 nTPM (protected, limit 5); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 5); rectum: 13.6 nTPM (protected, limit 5); esophagus: 13.4 nTPM (protected, limit 5); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (protected, limit 5); gallbladder: 11.7 nTPM (protected, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188782,True,compatible,,True,0,6,partial,0.2,0,,,44,not_established,not_triggered,,,CATSPER4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188784,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,PLA2G2E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000188785,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,25.9,23.2,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 5); urinary bladder: 8.1 nTPM (protected, limit 5); rectum: 7.9 nTPM (protected, limit 5); esophagus: 7.8 nTPM (protected, limit 5); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF548,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 5); appendix: 16.4 nTPM (protected, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (protected, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (protected, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); gallbladder: 10.9 nTPM (protected, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 5); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 5); urinary bladder: 8.1 nTPM (protected, limit 5); rectum: 7.9 nTPM (protected, limit 5); esophagus: 7.8 nTPM (protected, limit 5); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000188800,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,not_triggered,,,TMCO2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000188848,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,1.7,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,BEND4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000188859,True,compatible,,True,0,80,unavailable,0.8,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,FAM78B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000188877,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEA,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000188909,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.9,0,,,0,not_established,not_triggered,,,BSX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000188931,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,207.8,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 5); heart muscle: 38.2 nTPM (vital, limit 5); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 5); thyroid gland: 25.6 nTPM (protected, limit 10); esophagus: 17.7 nTPM (protected, limit 10); kidney: 16.1 nTPM (vital, limit 5); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 5); adrenal gland: 12.9 nTPM (vital, limit 5); basal ganglia: 12.5 nTPM (vital, limit 1); hippocampal formation: 11.1 nTPM (vital, limit 1); adipose tissue: 11.1 nTPM (protected, limit 10); small intestine: 10.8 nTPM (vital, limit 5); duodenum: 10.1 nTPM (vital, limit 5); liver: 9.7 nTPM (vital, limit 5); pancreas: 9.4 nTPM (vital, limit 5); midbrain: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP126,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 5); heart muscle: 38.2 nTPM (vital, limit 5); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 5); thyroid gland: 25.6 nTPM (protected, limit 10); esophagus: 17.7 nTPM (protected, limit 10); kidney: 16.1 nTPM (vital, limit 5); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 5); adrenal gland: 12.9 nTPM (vital, limit 5); basal ganglia: 12.5 nTPM (vital, limit 1); gallbladder: 11.3 nTPM (protected, limit 10); hippocampal formation: 11.1 nTPM (vital, limit 1); adipose tissue: 11.1 nTPM (protected, limit 10); small intestine: 10.8 nTPM (vital, limit 5); duodenum: 10.1 nTPM (vital, limit 5); liver: 9.7 nTPM (vital, limit 5); pancreas: 9.4 nTPM (vital, limit 5); midbrain: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000189023,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEB16,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000189037,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,not_triggered,,,DUSP21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189052,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,8.4,0.3,"pituitary gland: 8.4 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,CGB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bradley 2020;Gong 2021;da Silva 2017,False,False,"pituitary gland: 8.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189064,True,compatible,,True,0,4,partial,0.8,0,,,45,not_established,not_triggered,,,GAGE2A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000189090,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,18.1,"esophagus: 18.1 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; thymus; tonsil,FAM25G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"esophagus: 18.1 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189114,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,12.2,7.4,"bone marrow: 12.2 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 5); lymph node: 7.4 nTPM (protected, limit 5); cerebral cortex: 7.4 nTPM (vital, limit 2); adipose tissue: 6.5 nTPM (protected, limit 5); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 5); esophagus: 6.2 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BLOC1S3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 12.2 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 2); stomach: 7.4 nTPM (protected, limit 5); lymph node: 7.4 nTPM (protected, limit 5); adipose tissue: 6.5 nTPM (protected, limit 5); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 5); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); appendix: 5.7 nTPM (protected, limit 5); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 5); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000189132,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FAM47B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189134,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.2,3.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NKAPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189139,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,FSCB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189144,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,2.5,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF573,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000189164,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,2.9,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF527,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189167,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0.1,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ZAR1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000189169,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP10-12,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000189186,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DCAF8L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000189252,True,compatible,,True,0,80,unavailable,0.8,0,,,0,not_established,not_triggered,,,SPANXN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189269,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,8.9,"parathyroid gland: 8.9 nTPM (protected, limit 5); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,DRICH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"parathyroid gland: 8.9 nTPM (protected, limit 5); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189298,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,4.5,4.6,"smooth muscle: 4.5 nTPM (vital, limit 1); retina: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZKSCAN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"smooth muscle: 4.5 nTPM (vital, limit 1); retina: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000189299,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FOXR2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189326,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPANXN4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189357,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31D4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189362,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,3.6,"cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NEMP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000189375,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,TBC1D28,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000189401,True,compatible,,True,0,6,partial,0.7,0.3,,,44,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,OTUD6A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,True,True,,,,unchanged
ENSG00000196074,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.4,5.9,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 5); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 5); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196109,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,3.6,"kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ZNF676,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196119,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,OR8A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000196172,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,2.7,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF681,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196184,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR10J1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000196233,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,25.2,8.4,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 5); rectum: 8.3 nTPM (protected, limit 5); stomach: 8.1 nTPM (protected, limit 5); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 5); urinary bladder: 6.5 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 5); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); kidney: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); lung: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,LCOR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 5); rectum: 8.3 nTPM (protected, limit 5); stomach: 8.1 nTPM (protected, limit 5); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 5); urinary bladder: 6.5 nTPM (protected, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 5); appendix: 6 nTPM (protected, limit 5); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); kidney: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); lung: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196242,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,OR2C3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000196335,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,1.3,0.4,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; thymus,STK31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,False,False,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196341,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,OR8D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000196350,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZNF729,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000196357,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.2,4.4,"spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF565,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196388,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.4,8.3,"skeletal muscle: 10.4 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 5); thyroid gland: 7.7 nTPM (protected, limit 5); small intestine: 7.6 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,INCA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"skeletal muscle: 10.4 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 5); thyroid gland: 7.7 nTPM (protected, limit 5); small intestine: 7.6 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); gallbladder: 6.6 nTPM (protected, limit 5); appendix: 6.2 nTPM (protected, limit 5); heart muscle: 6.2 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196391,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.9,6.9,"tongue: 6.9 nTPM (protected, limit 5); rectum: 6.8 nTPM (protected, limit 5); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF774,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 6.9 nTPM (protected, limit 5); rectum: 6.8 nTPM (protected, limit 5); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196406,True,compatible,,True,0,3,partial,0,0,,,44,not_established,not_triggered,,,SPANXD,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000196417,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.4,8.5,"parathyroid gland: 8.5 nTPM (protected, limit 5); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF765,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 8.5 nTPM (protected, limit 5); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196418,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.3,6,"colon: 6 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF124,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"colon: 6 nTPM (protected, limit 5); rectum: 5.5 nTPM (protected, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196427,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,1.1,0.3,"small intestine: 1.1 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; thymus,NBPF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196431,False,excluded,positive_ihc_outside_permitted,True,0,0,routine_complete,0.2,0.1,,eye / lens fiber cells: High (Supported),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen; thymus; tonsil,CRYBA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,,eye / lens fiber cells: High (Supported),positive_ihc_outside_permitted,unchanged
ENSG00000196437,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,13.3,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF569,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (protected, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196460,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.7,0.6,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,RFX8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 3.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196466,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,3.7,2.8,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF799,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196470,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,27.8,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); liver: 22 nTPM (vital, limit 1); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (protected, limit 5); tongue: 16.6 nTPM (protected, limit 5); small intestine: 15.8 nTPM (vital, limit 1); colon: 15.5 nTPM (protected, limit 5); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 5); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 5); hippocampal formation: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); smooth muscle: 14 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); urinary bladder: 13.7 nTPM (protected, limit 5); lymph node: 13.6 nTPM (protected, limit 5); esophagus: 13.6 nTPM (protected, limit 5); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,SIAH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (protected, limit 5); liver: 22 nTPM (vital, limit 1); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (protected, limit 5); tongue: 16.6 nTPM (protected, limit 5); small intestine: 15.8 nTPM (vital, limit 1); colon: 15.5 nTPM (protected, limit 5); duodenum: 15.5 nTPM (vital, limit 1); gallbladder: 15.3 nTPM (protected, limit 5); stomach: 15.3 nTPM (protected, limit 5); cerebral cortex: 15.3 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 5); hippocampal formation: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 5); smooth muscle: 14 nTPM (vital, limit 1); urinary bladder: 13.7 nTPM (protected, limit 5); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 5); esophagus: 13.6 nTPM (protected, limit 5); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); appendix: 10.5 nTPM (protected, limit 5); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196475,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GK2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000196505,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,7.9,4.7,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,GDAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196511,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,13.6,6.1,"duodenum: 13.6 nTPM (vital, limit 1); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TPK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"duodenum: 13.6 nTPM (vital, limit 1); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 5); rectum: 5.8 nTPM (protected, limit 5); appendix: 5.7 nTPM (protected, limit 5); lymph node: 5.6 nTPM (protected, limit 5); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196550,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.5,10.7,"lymph node: 10.7 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM72A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 10.7 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); appendix: 5.9 nTPM (protected, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196553,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CCDC196,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,True,True,,,,unchanged
ENSG00000196565,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,77,6.6,"bone marrow: 77 nTPM (vital, limit 1); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); adipose tissue: 6.6 nTPM (protected, limit 5); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); hippocampal formation: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,HBG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"bone marrow: 77 nTPM (vital, limit 1); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); adipose tissue: 6.6 nTPM (protected, limit 5); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); gallbladder: 5.1 nTPM (protected, limit 5); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); hippocampal formation: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); gallbladder / glandular cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196570,True,compatible,,True,0,80,unavailable,0.9,0,,,0,not_established,not_triggered,,,PFN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000196578,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5AC2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000196584,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.7,3.1,"bone marrow: 5.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,XRCC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196597,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,9,3.3,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF782,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196604,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,POTEF,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000196605,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,10.1,12.7,"urinary bladder: 12.7 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); adipose tissue: 7.6 nTPM (protected, limit 5); parathyroid gland: 7 nTPM (protected, limit 5); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); amygdala: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 5); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZNF846,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"urinary bladder: 12.7 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); gallbladder: 9 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); colon: 7.9 nTPM (protected, limit 5); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 5); adipose tissue: 7.6 nTPM (protected, limit 5); parathyroid gland: 7 nTPM (protected, limit 5); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); hippocampal formation: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 5); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); appendix: 5.8 nTPM (protected, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000196632,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,3.5,0.9,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,WNK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196659,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,5.1,7.9,"thyroid gland: 7.9 nTPM (protected, limit 7.5); retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IFT70B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 7.9 nTPM (protected, limit 7.5); retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196689,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,24,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); stomach: 5.7 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRPV1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (protected, limit 5); stomach: 5.7 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196712,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,26.1,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (protected, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 5); colon: 9.9 nTPM (protected, limit 5); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 5); choroid plexus: 9.5 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); small intestine: 8.7 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 5); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,NF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (protected, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 5); kidney: 13.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 5); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 5); colon: 9.9 nTPM (protected, limit 5); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 5); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); gallbladder: 8.7 nTPM (protected, limit 5); small intestine: 8.7 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); appendix: 7.6 nTPM (protected, limit 5); esophagus: 6.4 nTPM (protected, limit 5); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196748,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,5,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,CLPSL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196772,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,OR14A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000196832,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,OR11G2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000196834,True,compatible,,True,0,80,unavailable,0.4,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,POTEI,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,True,True,,,,unchanged
ENSG00000196844,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,PATE2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000196860,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,0.4,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,TOMM20L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000196862,True,compatible,,True,0,80,unavailable,1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,RGPD4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000196900,True,compatible,,True,0,80,unavailable,0.2,0.6,,,0,not_established,not_triggered,,,SPMIP10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000196911,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,19.5,12.4,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 5); thyroid gland: 11.1 nTPM (protected, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 5); smooth muscle: 6.6 nTPM (vital, limit 5); lung: 5.9 nTPM (vital, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,KPNA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 5); thyroid gland: 11.1 nTPM (protected, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 5); smooth muscle: 6.6 nTPM (vital, limit 5); lung: 5.9 nTPM (vital, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); appendix: 5.4 nTPM (protected, limit 5); kidney: 5.3 nTPM (vital, limit 1); gallbladder: 5.1 nTPM (protected, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000196912,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.9,2.9,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANKRD36B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000196946,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ZNF705A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197054,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,6.7,4.7,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF763,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197079,True,compatible,,True,0,6,partial,0,1.9,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,KRT35,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000197123,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZNF679,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000197134,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.1,2.5,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF257,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197140,True,compatible,,True,0,6,partial,1.7,0.9,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ADAM32,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000197153,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,7,partial,1.2,1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H3C12,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000197172,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,MAGEA6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000197181,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.8,1.4,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PIWIL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197183,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,48,16.6,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 5); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 5); stomach: 13 nTPM (protected, limit 5); amygdala: 13 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (protected, limit 5); thyroid gland: 9.3 nTPM (protected, limit 5); urinary bladder: 9.3 nTPM (protected, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 5); lymph node: 8.1 nTPM (protected, limit 5); liver: 6.7 nTPM (vital, limit 5); smooth muscle: 6.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 5)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,NOL4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 5); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 5); stomach: 13 nTPM (protected, limit 5); amygdala: 13 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (protected, limit 5); basal ganglia: 9.3 nTPM (vital, limit 1); appendix: 9.3 nTPM (protected, limit 5); thyroid gland: 9.3 nTPM (protected, limit 5); urinary bladder: 9.3 nTPM (protected, limit 5); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 5); gallbladder: 8.3 nTPM (protected, limit 5); lymph node: 8.1 nTPM (protected, limit 5); liver: 6.7 nTPM (vital, limit 5); smooth muscle: 6.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 5)",adipose tissue / adipocytes: Low (Enhanced); appendix / glandular cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197213,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0.3,0,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),47,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,ZSCAN5B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,,appendix / glandular cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),positive_ihc_outside_permitted,unchanged
ENSG00000197217,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,31.7,28.6,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 5); parathyroid gland: 26.2 nTPM (protected, limit 5); small intestine: 25.5 nTPM (vital, limit 1); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 5); rectum: 19.6 nTPM (protected, limit 5); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 5); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 5); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (protected, limit 7.5); tongue: 15.3 nTPM (protected, limit 5); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (protected, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 7.5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENTPD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 5); parathyroid gland: 26.2 nTPM (protected, limit 5); small intestine: 25.5 nTPM (vital, limit 1); appendix: 23.5 nTPM (protected, limit 5); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 5); rectum: 19.6 nTPM (protected, limit 5); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 5); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 5); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (protected, limit 7.5); tongue: 15.3 nTPM (protected, limit 5); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (protected, limit 5); gallbladder: 14.1 nTPM (protected, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 7.5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); appendix / endocrine cells: High (Supported); appendix / enterocytes: High (Supported); appendix / germinal center cells: High (Supported); appendix / goblet cells: High (Supported); appendix / non-germinal center cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); gallbladder / glandular cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197233,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR1J2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000197275,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,6.8,2.7,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RAD54B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197279,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.9,6.2,"parathyroid gland: 6.2 nTPM (protected, limit 5); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF165,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"parathyroid gland: 6.2 nTPM (protected, limit 5); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197309,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR10D3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000197343,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,20.5,26.2,"esophagus: 26.2 nTPM (protected, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 5); urinary bladder: 18.1 nTPM (protected, limit 5); stomach: 17.5 nTPM (protected, limit 5); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 5); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (protected, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF655,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"esophagus: 26.2 nTPM (protected, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 5); urinary bladder: 18.1 nTPM (protected, limit 5); stomach: 17.5 nTPM (protected, limit 5); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 5); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); appendix: 13.9 nTPM (protected, limit 5); parathyroid gland: 13.9 nTPM (protected, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (protected, limit 5); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (protected, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); gallbladder: 9.8 nTPM (protected, limit 5); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197360,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,35.9,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ZNF98,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197372,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,11.2,12.6,"lymph node: 12.6 nTPM (protected, limit 5); rectum: 11.8 nTPM (protected, limit 5); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); thyroid gland: 8.3 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (protected, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 5); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF675,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 12.6 nTPM (protected, limit 5); rectum: 11.8 nTPM (protected, limit 5); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 5); thyroid gland: 8.3 nTPM (protected, limit 5); colon: 8 nTPM (protected, limit 5); pancreas: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 5); adipose tissue: 7.2 nTPM (protected, limit 5); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); appendix: 6.3 nTPM (protected, limit 5); esophagus: 5.8 nTPM (protected, limit 5); small intestine: 5.8 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 5); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); gallbladder: 5.2 nTPM (protected, limit 5); cerebellum: 5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197410,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,1.7,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,DCHS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197416,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,54.5,2.4,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),45,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,FABP12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197437,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR13G1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000197557,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,8,partial,8,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,IFT70A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197566,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,2.6,2.4,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF624,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197584,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,0,routine_complete,5.6,2.9,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,KCNMB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197587,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.7,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,DMBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000197617,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,9,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,VN1R5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000197651,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CCER1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000197653,False,excluded,positive_ihc_outside_permitted,True,0,6,partial,1.2,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,DNAH10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000197683,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP26-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000197714,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.9,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF460,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197748,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,96.9,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (protected, limit 5); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197768,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,STPG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197779,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,4.2,3.4,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF81,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197798,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,29.8,23.2,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 5); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 5); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); lung: 15.7 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 5); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 5); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); urinary bladder: 13.1 nTPM (protected, limit 5); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 5); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); esophagus: 7.4 nTPM (protected, limit 5); parathyroid gland: 7.4 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,FAM118B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 5); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 5); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 5); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 5); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); urinary bladder: 13.1 nTPM (protected, limit 5); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 5); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); gallbladder: 10.1 nTPM (protected, limit 5); kidney: 10 nTPM (vital, limit 1); appendix: 10 nTPM (protected, limit 5); thyroid gland: 9.9 nTPM (protected, limit 5); adipose tissue: 9 nTPM (protected, limit 5); retina: 8.8 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 5); esophagus: 7.4 nTPM (protected, limit 5); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197826,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,5.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; thymus,CFAP299,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000197849,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,OR8G1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000197863,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,8.5,7.8,"liver: 8.5 nTPM (vital, limit 1); retina: 7.8 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 5); lymph node: 5.3 nTPM (protected, limit 5); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF790,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 8.5 nTPM (vital, limit 1); retina: 7.8 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (protected, limit 5); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 5); lymph node: 5.3 nTPM (protected, limit 5); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197889,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen; thymus; tonsil,MEIG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000197928,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,11.3,11.5,"thyroid gland: 11.5 nTPM (protected, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 5); smooth muscle: 9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); urinary bladder: 7.5 nTPM (protected, limit 5); tongue: 6.9 nTPM (protected, limit 5); colon: 6.6 nTPM (protected, limit 5); lymph node: 6.2 nTPM (protected, limit 5); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); lung: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); stomach: 5.2 nTPM (protected, limit 5); pancreas: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZNF677,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"thyroid gland: 11.5 nTPM (protected, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 5); smooth muscle: 9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (protected, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); urinary bladder: 7.5 nTPM (protected, limit 5); gallbladder: 7.1 nTPM (protected, limit 5); tongue: 6.9 nTPM (protected, limit 5); colon: 6.6 nTPM (protected, limit 5); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); lung: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 5); appendix: 5.3 nTPM (protected, limit 5); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 5); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000197935,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,1,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ZNF311,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000197977,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,50.9,9.4,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 5); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ELOVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 5); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198021,True,compatible,,True,0,3,partial,0,0,,,44,not_established,not_triggered,,,SPANXA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000198028,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ZNF560,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,False,False,"retina: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198033,True,compatible,family_exclusion,True,0,80,unavailable,0.2,0.5,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,TUBA3C,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,True,,,family_exclusion,unchanged
ENSG00000198062,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEH,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000198088,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,13.4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (protected, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,NUP62CL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (protected, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198092,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,0,14.7,"esophagus: 14.7 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,TMPRSS11F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"esophagus: 14.7 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000198129,True,compatible,existing_nomination_or_manual_review,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,DEFB107B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000198173,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,FAM47C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000198178,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,1.5,5.3,"lymph node: 5.3 nTPM (protected, limit 5); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CLEC4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"lymph node: 5.3 nTPM (protected, limit 5); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198182,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.7,5,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF607,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198183,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,17.7,0.9,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; thymus; tonsil,BPIFA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198205,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,3,2.9,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZXDA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198283,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5B21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000198298,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,3.1,"pancreas: 4 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF485,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 4 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198326,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.8,0,,,0,not_established,not_triggered,,,TMEM239,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000198346,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,2.3,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF813,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198390,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP13-1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000198440,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,3.9,"cerebellum: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF583,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198445,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CCT8L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000198453,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.4,5.9,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF568,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 5); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198466,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,11.2,12.7,"rectum: 12.7 nTPM (protected, limit 5); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); esophagus: 6 nTPM (protected, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ZNF587,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"rectum: 12.7 nTPM (protected, limit 5); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 5); colon: 8.3 nTPM (protected, limit 5); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (protected, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); appendix: 6.3 nTPM (protected, limit 5); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 5); esophagus: 6 nTPM (protected, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 5); smooth muscle: 5.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198471,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,RTP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198521,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.7,8.5,"bone marrow: 10.7 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); lymph node: 8.1 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.4 nTPM (protected, limit 5); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 5); kidney: 4.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 10.7 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); lymph node: 8.1 nTPM (protected, limit 5); retina: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.4 nTPM (protected, limit 5); cerebral cortex: 5.8 nTPM (vital, limit 1); appendix: 5.5 nTPM (protected, limit 5); rectum: 5.1 nTPM (protected, limit 5); kidney: 4.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198554,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,7.1,5.4,"bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,WDHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 5); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: High (Enhanced); bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198573,True,compatible,,True,0,3,partial,0,0,,,44,not_established,not_triggered,,,SPANXC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000198586,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,15.7,17.5,"parathyroid gland: 17.5 nTPM (protected, limit 5); thyroid gland: 17.1 nTPM (protected, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 5); liver: 14.3 nTPM (vital, limit 1); stomach: 13.1 nTPM (protected, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); colon: 12.6 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 5); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 5); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,TLK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"parathyroid gland: 17.5 nTPM (protected, limit 5); thyroid gland: 17.1 nTPM (protected, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 5); liver: 14.3 nTPM (vital, limit 1); stomach: 13.1 nTPM (protected, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); colon: 12.6 nTPM (protected, limit 5); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 5); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 5); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); appendix: 10.4 nTPM (protected, limit 5); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); gallbladder: 9.3 nTPM (protected, limit 5); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (protected, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 5)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198681,True,compatible,,True,0,5,partial,0,0,,,43,not_established,not_triggered,,,MAGEA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000198691,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,343.6,0.2,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ABCA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198704,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GPX6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000198723,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0.2,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,SAXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,False,False,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198754,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,6.3,1.7,"heart muscle: 6.3 nTPM (vital, limit 5); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OXCT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"heart muscle: 6.3 nTPM (vital, limit 5); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198759,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,24.8,19.5,"lung: 24.8 nTPM (vital, limit 5); adipose tissue: 19.5 nTPM (protected, limit 10); urinary bladder: 10.3 nTPM (protected, limit 10); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,EGFL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1158/0008-5472.CAN-16-0225,Bai 2016,False,False,"lung: 24.8 nTPM (vital, limit 5); adipose tissue: 19.5 nTPM (protected, limit 10); urinary bladder: 10.3 nTPM (protected, limit 10); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198765,True,compatible,,True,0,4,partial,0,0.1,,,45,not_established,not_triggered,,,SYCP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000198785,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.4,0.4,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,GRIN3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198798,True,compatible,,True,0,1,partial,0,0,,,46,not_established,not_triggered,,,MAGEB3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000198815,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,40.6,28,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 5); adipose tissue: 22.4 nTPM (protected, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (protected, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 5); rectum: 17.6 nTPM (protected, limit 5); lymph node: 17.4 nTPM (protected, limit 5); colon: 17.2 nTPM (protected, limit 5); small intestine: 17.1 nTPM (vital, limit 1); smooth muscle: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 5); hippocampal formation: 16.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 5); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FOXJ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 5); adipose tissue: 22.4 nTPM (protected, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (protected, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 5); rectum: 17.6 nTPM (protected, limit 5); lymph node: 17.4 nTPM (protected, limit 5); colon: 17.2 nTPM (protected, limit 5); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 5); hippocampal formation: 16.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 5); amygdala: 14.7 nTPM (vital, limit 1); appendix: 14.5 nTPM (protected, limit 5); kidney: 13 nTPM (vital, limit 1); gallbladder: 12.7 nTPM (protected, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198816,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,169.4,141.1,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 5); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 5); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 5); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (protected, limit 5); stomach: 65.9 nTPM (protected, limit 5); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (protected, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 5); small intestine: 46.5 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 5); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 5); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF358,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 5); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 5); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 5); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (protected, limit 5); stomach: 65.9 nTPM (protected, limit 5); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (protected, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); lung: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 5); small intestine: 46.5 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 5); gallbladder: 30.7 nTPM (protected, limit 5); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 5); appendix: 11.7 nTPM (protected, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 5); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198826,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,8,partial,23.5,12.9,"bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); rectum: 8.4 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),39,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ARHGAP11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 5); rectum: 8.4 nTPM (protected, limit 5); appendix: 7.4 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198865,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,173.9,7.3,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); lymph node: 7.2 nTPM (protected, limit 5); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CCDC152,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (protected, limit 5); lymph node: 7.2 nTPM (protected, limit 5); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 5); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198870,True,compatible,,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,STKLD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000198883,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,21.7,0.1,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,PNMA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198885,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,3.8,"cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ITPRIPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000198889,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,1.5,0.8,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,DCAF12L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000198919,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,28.9,15.6,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 5); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (protected, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 5); adrenal gland: 9.4 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); stomach: 6.4 nTPM (protected, limit 5); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,DZIP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 5); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (protected, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 5); adrenal gland: 9.4 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 5); stomach: 6.4 nTPM (protected, limit 5); lung: 6.3 nTPM (vital, limit 1); gallbladder: 5.7 nTPM (protected, limit 5); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000198930,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.9,0.3,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,CSAG1,current_adaptive,False,True,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,10.1038/ncomms10499,Wang 2016,False,False,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000198948,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,41.1,9.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 5); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MFAP3L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 5); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000203326,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6,13.6,"parathyroid gland: 13.6 nTPM (protected, limit 5); lymph node: 7.7 nTPM (protected, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); adrenal gland: 4.5 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF525,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 13.6 nTPM (protected, limit 5); lymph node: 7.7 nTPM (protected, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 5); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); adrenal gland: 4.5 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203666,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,20.3,21.4,"thyroid gland: 21.4 nTPM (protected, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 5); spinal cord: 10.1 nTPM (vital, limit 1); lung: 10 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 5); adipose tissue: 9.5 nTPM (protected, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 5); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,EFCAB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"thyroid gland: 21.4 nTPM (protected, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); gallbladder: 12.6 nTPM (protected, limit 5); rectum: 10.8 nTPM (protected, limit 5); spinal cord: 10.1 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 5); heart muscle: 10 nTPM (vital, limit 1); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (protected, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 5); esophagus: 9 nTPM (protected, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 5); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5); colon: 5.2 nTPM (protected, limit 5); appendix: 5.2 nTPM (protected, limit 5); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000203772,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,25.1,3.5,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SPRN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203778,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,101.6,42,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 5); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (protected, limit 5); colon: 20.4 nTPM (protected, limit 5); urinary bladder: 18.4 nTPM (protected, limit 5); stomach: 18.1 nTPM (protected, limit 5); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (protected, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 13.2 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 5); rectum: 5.2 nTPM (protected, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM229B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 5); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (protected, limit 5); colon: 20.4 nTPM (protected, limit 5); gallbladder: 18.5 nTPM (protected, limit 5); urinary bladder: 18.4 nTPM (protected, limit 5); stomach: 18.1 nTPM (protected, limit 5); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (protected, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 5); skeletal muscle: 13.2 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 5); rectum: 5.2 nTPM (protected, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203780,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,66.4,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 5); midbrain: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FANK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (protected, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 5); midbrain: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203784,True,compatible,,True,0,1,partial,0.4,0.3,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; thymus,LELP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203795,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,FAM24A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203857,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,8.4,0.4,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,HSD3B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000203907,True,compatible,,True,0,4,partial,0.9,0.5,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,OOEP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025,True,True,,,,unchanged
ENSG00000203909,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,DPPA5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000203910,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.2,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,C1orf146,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"retina: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203923,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPANXN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203926,True,compatible,,True,0,3,partial,0,0,,,44,not_established,not_triggered,,,SPANXA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000203933,True,compatible,,True,0,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,CXorf66,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203942,True,compatible,,True,0,5,partial,0.8,0.2,,,44,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,C10orf62,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203963,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,0.1,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,C1orf141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000203970,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB110,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000203989,True,compatible,,True,0,2,partial,0.1,0,,,46,not_established,not_triggered,,,RHOXF2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000203995,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.8,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZYG11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204006,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,not_triggered,,,C1orf185,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204007,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GLT6D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204019,True,compatible,,True,0,80,unavailable,0,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CT83,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000204022,True,compatible,,True,0,80,unavailable,0.5,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,LIPJ,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000204025,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,TRPC5OS,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000204052,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,12.5,3.5,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 5); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,LRRC73,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 5); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000204086,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,0.4,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RPA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000204140,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,173.3,0.1,"pancreas: 173.3 nTPM (vital, limit 5); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,45,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CLPSL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 173.3 nTPM (vital, limit 5); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204165,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,CXorf65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"small intestine: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204193,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,TXNDC8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204246,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR13C3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000204279,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PAGE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204296,True,compatible,,True,0,1,partial,0.1,0.2,,,47,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,TSBP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000204300,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TMEM225,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204311,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.2,3.6,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PJVK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204334,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,46.7,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (protected, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ERICH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (protected, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 5); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204363,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPANXN5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204379,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,XAGE1A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000204382,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,XAGE1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,False,False,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204390,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,3.8,1.7,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,HSPA1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000204414,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,0.8,0.3,,pituitary gland / cells in anterior : High (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen; thymus,CSHL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,pituitary gland / cells in anterior : High (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000204449,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM49C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204478,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000204480,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,PRAMEF19,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204481,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000204501,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRAMEF15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204505,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,32.1,0.5,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,PRAMEF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000204524,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,6.6,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),42,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF805,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000204536,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,19.1,15.7,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 5); thyroid gland: 15.6 nTPM (protected, limit 5); esophagus: 14.7 nTPM (protected, limit 5); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 5); urinary bladder: 12.9 nTPM (protected, limit 5); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (protected, limit 5); duodenum: 9.6 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCHCR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 5); thyroid gland: 15.6 nTPM (protected, limit 5); esophagus: 14.7 nTPM (protected, limit 5); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 5); urinary bladder: 12.9 nTPM (protected, limit 5); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (protected, limit 5); duodenum: 9.6 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 5); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204540,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,1.5,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,PSORS1C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204548,True,compatible,existing_nomination_or_manual_review,True,0,2,partial,0,0,,,44,not_established,not_triggered,,,DEFB121,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000204614,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,2,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,TRIM40,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204640,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.8,0.1,,,0,not_established,not_triggered,,,NMS,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204659,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,CBY3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204661,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,SPATA31J1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000204669,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,C9orf57,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204671,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IL31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000204688,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR2H1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204694,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR11A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000204695,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,1.8,0.3,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,OR14J1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204700,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,OR2J2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204701,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,OR2J3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204704,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR2W1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204764,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,RANBP17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204849,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204897,True,compatible,,True,0,4,partial,0.1,2.6,,,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,KRT25,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000204918,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204919,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000204930,False,excluded,positive_ihc_outside_permitted,True,0,5,partial,2.8,0.5,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,FAM221B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000204941,True,compatible,,True,0,2,partial,0.8,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,PSG5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000204947,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,2.3,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF425,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204952,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FBXO47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000204956,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.8,0.5,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHGA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000204961,True,compatible,,True,0,80,unavailable,0.8,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PCDHA9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000204962,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.8,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,PCDHA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000204963,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.7,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,PCDHA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000204965,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,0,routine_complete,2.8,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),48,not_established,required,in_situ_inflammation_review,gallbladder,PCDHA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000204967,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,2,0.3,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,PCDHA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",appendix / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000204969,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,2.4,0.2,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,PCDHA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000204970,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,2.8,0.1,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),46,not_established,not_triggered,,,PCDHA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000204979,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MS4A13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000205078,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.1,3.3,"hypothalamus: 3.1 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCE1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"hypothalamus: 3.1 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205085,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.3,2,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GARIN1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205108,True,compatible,,True,0,2,partial,0,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SPATA31F1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000205111,True,compatible,,True,0,80,unavailable,0.7,0.1,,,0,not_established,not_triggered,,,CDKL4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000205129,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,30.8,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CFAP96,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000205133,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,30.4,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (protected, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 5); colon: 20 nTPM (protected, limit 5); parathyroid gland: 19.9 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 5); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 5); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); adipose tissue: 12.3 nTPM (protected, limit 5); amygdala: 12.3 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 5); lymph node: 5.2 nTPM (protected, limit 5); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRIQK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (protected, limit 5); gallbladder: 22.2 nTPM (protected, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 5); colon: 20 nTPM (protected, limit 5); parathyroid gland: 19.9 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 5); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 5); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); adipose tissue: 12.3 nTPM (protected, limit 5); amygdala: 12.3 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); appendix: 7.5 nTPM (protected, limit 5); tongue: 5.4 nTPM (protected, limit 5); lymph node: 5.2 nTPM (protected, limit 5); skeletal muscle: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205177,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,4.6,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,C11orf91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205208,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,14.3,5.9,"bone marrow: 14.3 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 5); tongue: 5.8 nTPM (protected, limit 5); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,C4orf46,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"bone marrow: 14.3 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 5); tongue: 5.8 nTPM (protected, limit 5); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000205301,True,compatible,,True,0,1,partial,0.1,0,,,47,not_established,not_triggered,,,MGAT4D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000205359,True,compatible,,True,0,2,partial,0,0,,,47,not_established,not_triggered,,,SLCO6A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000205409,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR52E6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000205442,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IZUMO3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000205445,True,compatible,,True,0,80,unavailable,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP10-2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000205456,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.7,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen; thymus,TP53TG3D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"cerebellum: 2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205457,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,TP53TG3C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000205639,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,11.7,0,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,MFSD2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000205642,True,compatible,,True,0,7,partial,0.4,0.1,,,46,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,VCX3B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000205649,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,119.5,3.2,"pancreas: 119.5 nTPM (vital, limit 5); heart muscle: 25.2 nTPM (vital, limit 5); bone marrow: 18.7 nTPM (vital, limit 5); pituitary gland: 1.7 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,HTN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 119.5 nTPM (vital, limit 5); heart muscle: 25.2 nTPM (vital, limit 5); bone marrow: 18.7 nTPM (vital, limit 5); pituitary gland: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205707,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,117.6,97.6,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 5); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (protected, limit 5); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 5); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 5); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (protected, limit 5); hypothalamus: 26.1 nTPM (vital, limit 1); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 5); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 5); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 5); urinary bladder: 17.4 nTPM (protected, limit 5); colon: 17.3 nTPM (protected, limit 5); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ETFRF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 5); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (protected, limit 5); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 5); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 5); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (protected, limit 5); hypothalamus: 26.1 nTPM (vital, limit 1); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); gallbladder: 21.8 nTPM (protected, limit 5); esophagus: 21.8 nTPM (protected, limit 5); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 5); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 5); urinary bladder: 17.4 nTPM (protected, limit 5); colon: 17.3 nTPM (protected, limit 5); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); appendix: 13.1 nTPM (protected, limit 5); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000205718,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MBD3L4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000205777,True,compatible,,True,0,4,partial,0.5,0,,,45,not_established,not_triggered,,,GAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000205784,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,1.7,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ARRDC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205832,True,compatible,,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; thymus,C16orf96,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,True,True,,,,unchanged
ENSG00000205835,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,GMNC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205838,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,1.4,0.8,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TTC23L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000205856,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,9.3,0.3,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),46,not_established,not_triggered,,,C22orf42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,False,False,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000205858,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,LRRC72,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000205882,True,compatible,,True,0,80,unavailable,0.5,0.3,,,0,not_established,not_triggered,,,DEFB134,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,True,True,,,,unchanged
ENSG00000205883,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,DEFB135,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000205916,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,0.1,25.2,"stomach: 25.2 nTPM (protected, limit 5)",,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,DAZ4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,False,False,"stomach: 25.2 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000205944,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,0,5.2,"stomach: 5.2 nTPM (protected, limit 5)",,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,DAZ2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,False,False,"stomach: 5.2 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000206026,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,SMIM21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000206043,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C18orf63,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000206052,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,21.6,12.1,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 5); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,DOK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 5); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); appendix / lymphoid tissue: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000206102,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP19-8,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000206113,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CFAP99,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000206150,True,compatible,,True,0,80,unavailable,0.8,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,RNASE13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000206181,False,excluded,positive_ihc_outside_permitted,True,0,2,partial,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ELOA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),positive_ihc_outside_permitted,unchanged
ENSG00000206203,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.5,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,TSSK2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000206260,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRR23A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000206530,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,8.4,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,CFAP44,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000206531,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CD200R1L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000206557,True,compatible,,True,0,80,unavailable,0.8,0,,,0,not_established,not_triggered,,,TRIM71,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,True,True,,,,unchanged
ENSG00000212122,True,compatible,,True,0,1,partial,0.1,0,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TSSK1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000212123,False,excluded,rna_above_tissue_ceiling,True,0,5,partial,11.6,5.9,"liver: 11.6 nTPM (vital, limit 5); kidney: 6.9 nTPM (vital, limit 5); pancreas: 6.1 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 5); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PRR22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"liver: 11.6 nTPM (vital, limit 5); kidney: 6.9 nTPM (vital, limit 5); pancreas: 6.1 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 5); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000212710,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CTAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000212916,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,2.8,2.2,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,MAP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000212933,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP12-4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000213020,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.1,3.8,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF611,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213024,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,32.4,37.3,"lymph node: 37.3 nTPM (protected, limit 5); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 5); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 5); duodenum: 22.8 nTPM (vital, limit 1); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 5); tongue: 20.8 nTPM (protected, limit 5); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 5); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (protected, limit 5); stomach: 18.8 nTPM (protected, limit 5); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 5); thyroid gland: 15.8 nTPM (protected, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NUP62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"lymph node: 37.3 nTPM (protected, limit 5); appendix: 35.7 nTPM (protected, limit 5); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 5); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 5); duodenum: 22.8 nTPM (vital, limit 1); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 5); tongue: 20.8 nTPM (protected, limit 5); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 5); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (protected, limit 5); stomach: 18.8 nTPM (protected, limit 5); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); gallbladder: 17.6 nTPM (protected, limit 5); parathyroid gland: 17.1 nTPM (protected, limit 5); thyroid gland: 15.8 nTPM (protected, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000213030,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,2.3,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,47,not_established,not_triggered,,,CGB8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"pituitary gland: 2.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213145,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,303.5,256.4,"small intestine: 303.5 nTPM (vital, limit 1); adipose tissue: 256.4 nTPM (protected, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (protected, limit 5); colon: 129.9 nTPM (protected, limit 5); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 5); urinary bladder: 110 nTPM (protected, limit 5); kidney: 106.5 nTPM (vital, limit 1); stomach: 91.6 nTPM (protected, limit 5); lymph node: 81.8 nTPM (protected, limit 5); rectum: 53.5 nTPM (protected, limit 5); tongue: 48.1 nTPM (protected, limit 5); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 5); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"small intestine: 303.5 nTPM (vital, limit 1); adipose tissue: 256.4 nTPM (protected, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (protected, limit 5); colon: 129.9 nTPM (protected, limit 5); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 5); urinary bladder: 110 nTPM (protected, limit 5); kidney: 106.5 nTPM (vital, limit 1); stomach: 91.6 nTPM (protected, limit 5); lymph node: 81.8 nTPM (protected, limit 5); appendix: 59.3 nTPM (protected, limit 5); rectum: 53.5 nTPM (protected, limit 5); tongue: 48.1 nTPM (protected, limit 5); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); gallbladder: 27.1 nTPM (protected, limit 5); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 5); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); appendix / lymphoid tissue: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000213186,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,17,11.8,"bone marrow: 17 nTPM (vital, limit 1); lymph node: 11.8 nTPM (protected, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TRIM59,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 17 nTPM (vital, limit 1); lymph node: 11.8 nTPM (protected, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213213,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,1.1,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC183,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,False,False,"retina: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213215,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR2F1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000213218,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,14.6,5,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen; thymus; tonsil,CSH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213231,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,2.1,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,TCL1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"bone marrow: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213265,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TSGA13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,True,True,,,,unchanged
ENSG00000213401,True,compatible,,True,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,MAGEA12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000213471,True,compatible,,True,0,4,partial,0.1,0.1,,,42,not_established,required,in_situ_inflammation_review,gallbladder,TTLL13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,True,True,,,,unchanged
ENSG00000213588,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZBTB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213714,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,11.6,1.3,"bone marrow: 11.6 nTPM (vital, limit 5)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM209B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,False,False,"bone marrow: 11.6 nTPM (vital, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000213782,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,1,partial,43,45.9,"urinary bladder: 45.9 nTPM (protected, limit 5); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 5); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 5); choroid plexus: 35.1 nTPM (vital, limit 1); thyroid gland: 32.3 nTPM (protected, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 5); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); stomach: 28.5 nTPM (protected, limit 5); colon: 28.4 nTPM (protected, limit 5); esophagus: 28.3 nTPM (protected, limit 5); adipose tissue: 27.9 nTPM (protected, limit 5); rectum: 25.5 nTPM (protected, limit 5); lung: 24.1 nTPM (vital, limit 1); adrenal gland: 23.4 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DDX47,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"urinary bladder: 45.9 nTPM (protected, limit 5); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 5); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 5); choroid plexus: 35.1 nTPM (vital, limit 1); thyroid gland: 32.3 nTPM (protected, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 5); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); stomach: 28.5 nTPM (protected, limit 5); colon: 28.4 nTPM (protected, limit 5); esophagus: 28.3 nTPM (protected, limit 5); adipose tissue: 27.9 nTPM (protected, limit 5); rectum: 25.5 nTPM (protected, limit 5); lung: 24.1 nTPM (vital, limit 1); adrenal gland: 23.4 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); appendix: 22.1 nTPM (protected, limit 5); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); gallbladder: 19.2 nTPM (protected, limit 5); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000213799,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.9,4.2,"bone marrow: 4.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF845,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 4.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000213927,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,6,partial,1.6,1.2,"bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,CCL27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000214107,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,MAGEB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000214216,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,IQCJ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000214226,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,1,partial,2.2,1.5,"liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,C17orf67,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",appendix / glandular cells: High (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Low (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000214274,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2920.4,56.6,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 5); rectum: 44.2 nTPM (protected, limit 5); adipose tissue: 36.4 nTPM (protected, limit 5); colon: 31.5 nTPM (protected, limit 5); pancreas: 29.9 nTPM (vital, limit 1); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 5); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 5); thyroid gland: 8.5 nTPM (protected, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 5); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ANG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 5); rectum: 44.2 nTPM (protected, limit 5); adipose tissue: 36.4 nTPM (protected, limit 5); colon: 31.5 nTPM (protected, limit 5); pancreas: 29.9 nTPM (vital, limit 1); gallbladder: 27.6 nTPM (protected, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 5); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 5); esophagus: 9.5 nTPM (protected, limit 5); thyroid gland: 8.5 nTPM (protected, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); appendix: 5.9 nTPM (protected, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 5); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000214300,True,compatible,,True,0,3,partial,0.1,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,SPDYE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000214324,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR23E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000214338,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8,2.2,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MTCL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000214360,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,EFCAB9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000214415,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,False,0,10,partial,1.7,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),63,not_established,not_triggered,,,GNAT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_evidence_inside,unchanged
ENSG00000214511,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.8,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,HIGD1C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000214681,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IQCF5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000214686,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,IQCF6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000214782,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,3,partial,18.1,0.2,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),46,not_established,required,lymphatic_and_immune_function_review,lymph node,MS4A18,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000214814,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,9,partial,4.4,42,"stomach: 42 nTPM (protected, limit 5); rectum: 10.4 nTPM (protected, limit 5); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),63,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,FER1L6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"stomach: 42 nTPM (protected, limit 5); rectum: 10.4 nTPM (protected, limit 5); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); appendix / goblet cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000214819,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.2,0.1,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,CDRT15L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000214842,True,compatible,,True,0,80,unavailable,0.3,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,RAD51AP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000214866,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.2,0.1,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; thymus; tonsil,DCDC2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,False,False,"choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000214897,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PNMA6E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000214929,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000214946,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.2,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,TBC1D26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000215009,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,ACSM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000215113,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CXorf49B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000215115,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CXorf49,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000215126,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,7,partial,7.1,2.8,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ZNG1F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000215131,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,C16orf90,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000215148,True,compatible,,True,0,80,unavailable,0.1,0.3,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,PRSS41,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000215186,False,excluded,rna_above_tissue_ceiling,True,0,1,partial,4.2,0,"liver: 4.2 nTPM (vital, limit 3)",,47,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,GOLGA6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,False,False,"liver: 4.2 nTPM (vital, limit 3)",,rna_above_tissue_ceiling,unchanged
ENSG00000215203,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,GRXCR1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000215262,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,KCNU1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000215269,True,compatible,,True,0,4,partial,1,5.9,,,45,not_established,not_triggered,,,GAGE12G,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000215274,True,compatible,,True,0,4,partial,0.8,0.2,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,GAGE10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,True,True,,,,unchanged
ENSG00000215277,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,25,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,RNF212B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,False,False,"kidney: 25 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000215343,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZNF705D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000215356,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZNF705B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000215372,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,ZNF705G,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000215421,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,5.1,3.6,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF407,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); appendix / glandular cells: Medium (Uncertain); appendix / lymphoid tissue: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000215455,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP10-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000215474,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,SKOR2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000215529,True,compatible,,True,0,80,unavailable,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; thymus; tonsil,EFCAB8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,True,True,,,,unchanged
ENSG00000215568,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GAB4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000215817,True,compatible,,True,0,80,unavailable,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ZC3H11B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,True,True,,,,unchanged
ENSG00000215883,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,7,partial,4.3,3.1,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,CYB5RL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000215906,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,3.8,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,LACTBL1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 3.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000215910,True,compatible,,True,0,6,partial,0.5,0.2,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,C1orf167,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000216649,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,GAGE12E,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000216937,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.6,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Chang 2019;Bruggeman 2018,False,False,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000217442,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SYCE3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000218819,True,compatible,,True,0,80,unavailable,0.9,0,,,0,not_established,not_triggered,,,TDRD15,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000218823,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,PAPOLB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000219073,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,48049.2,16.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 7.5); adipose tissue: 8.7 nTPM (protected, limit 7.5); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,CELA3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 7.5); adipose tissue: 8.7 nTPM (protected, limit 7.5); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000219435,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,1,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,CATSPERZ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000220205,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,470.8,175.2,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 5); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); thyroid gland: 99 nTPM (protected, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 5); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (protected, limit 5); stomach: 85.6 nTPM (protected, limit 5); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 5); choroid plexus: 75 nTPM (vital, limit 1); lymph node: 68.6 nTPM (protected, limit 5); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 5); esophagus: 59.1 nTPM (protected, limit 5); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 5); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,VAMP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 5); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); thyroid gland: 99 nTPM (protected, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 5); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (protected, limit 5); stomach: 85.6 nTPM (protected, limit 5); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 5); choroid plexus: 75 nTPM (vital, limit 1); lymph node: 68.6 nTPM (protected, limit 5); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 5); esophagus: 59.1 nTPM (protected, limit 5); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 5); appendix: 46.2 nTPM (protected, limit 5); duodenum: 41.9 nTPM (vital, limit 1); gallbladder: 37.7 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000221813,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,OR6B1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000221826,True,compatible,,True,0,2,partial,0.6,0.1,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,PSG3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000221843,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.5,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,SPATA31H1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000221855,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TAS2R41,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000221867,True,compatible,,True,0,80,unavailable,0,0.2,,,0,not_established,not_triggered,,,MAGEA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000221878,True,compatible,,True,0,2,partial,0.5,0,,,46,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,PSG7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000221882,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0.9,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; thymus; tonsil,OR3A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,False,False,,,incomplete_routine_rna,unchanged
ENSG00000221888,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,OR1C1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000221900,True,compatible,,True,0,3,partial,0,0,,,44,not_established,not_triggered,,,POM121L12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000221910,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR2F2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000221926,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,35.5,141.8,"esophagus: 141.8 nTPM (protected, limit 5); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 5); stomach: 32 nTPM (protected, limit 5); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 5); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (protected, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (protected, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 5); hypothalamus: 10.8 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 5); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,TRIM16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"esophagus: 141.8 nTPM (protected, limit 5); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 5); stomach: 32 nTPM (protected, limit 5); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 5); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (protected, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (protected, limit 5); gallbladder: 16.9 nTPM (protected, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 5); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 5); hypothalamus: 10.8 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 5); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); appendix: 7.7 nTPM (protected, limit 5); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000221947,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,5.2,1.6,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,XKR9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); appendix / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000221977,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4E2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000222028,True,compatible,,True,0,4,partial,0,0,,,44,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus; thymus / cortical cells,PSMB11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000222036,True,compatible,,True,0,80,unavailable,0.8,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,POTEM,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,True,True,,,,unchanged
ENSG00000223510,True,compatible,,True,0,80,unavailable,0.8,2.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,CDRT15,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000223591,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.9,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CENPVL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,False,False,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000223601,True,compatible,,True,0,80,unavailable,0.1,0.1,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,EBLN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000223614,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ZNF735,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000223802,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,166.6,11.3,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 5); skeletal muscle: 17.5 nTPM (vital, limit 5); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 5); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,CERS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 5); skeletal muscle: 17.5 nTPM (vital, limit 5); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 5); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000224089,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000224107,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,ETDB,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000224440,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CXorf51A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000224586,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GPX5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000224659,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,2.2,0.2,"retina: 2.2 nTPM (vital, limit 1)",,45,not_established,not_triggered,,,GAGE12J,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,False,False,"retina: 2.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000224902,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,GAGE12H,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000224960,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PPP4R3C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,True,True,,,,unchanged
ENSG00000225614,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF469,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000225781,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR6V1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000225828,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.7,6.3,"liver: 9.7 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,FAM229A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"liver: 9.7 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (protected, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000226023,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000226372,False,excluded,positive_ihc_outside_permitted,True,0,3,partial,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),45,not_established,not_triggered,,,DCAF8L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000226600,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000226650,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,KIF4B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000226685,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000226929,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000226941,True,compatible,,True,0,2,partial,0,0,,,45,not_established,not_triggered,,,RBMY1J,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000227059,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ANHX,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000227124,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.6,9.2,"kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (protected, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 5); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF717,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (protected, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 5); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 5); rectum: 6.5 nTPM (protected, limit 5); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 5); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000227151,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000227234,True,compatible,,True,0,3,partial,0.3,1,,,44,not_established,not_triggered,,,SPANXB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000227488,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,GAGE12D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000227868,True,compatible,,True,0,80,unavailable,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,TEX46,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000228075,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,BOD1L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000228372,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,SMIM10L2B-AS1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000228517,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000228567,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,VN1R4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000228836,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,1,partial,4.8,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,CT45A5,current_adaptive,False,True,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,False,False,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000228927,True,compatible,,True,0,1,partial,0,0.2,,,48,not_established,not_triggered,,,TSPY3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000229292,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.6,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,RFPL4AL1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000229549,True,compatible,,True,0,2,partial,0,0,,,46,not_established,not_triggered,,,TSPY8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000229665,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000229676,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.5,0.3,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF492,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 2.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000229894,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,GK3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Jamin 2021;Bruggeman 2018;Gong 2021;Carter 2023,True,True,,,,unchanged
ENSG00000229937,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRPS1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000229972,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,IQCF3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000230031,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEB2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000230054,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,TEX53,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000230178,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4F3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000230246,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,SPATA31C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna,unchanged
ENSG00000230268,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SSU72L6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000230301,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5H6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000230347,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000230522,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MBD3L2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000230594,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000230601,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,TEX48,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000231256,True,compatible,,True,0,3,partial,0.5,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,CFAP97D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000231887,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.8,10.7,"esophagus: 10.7 nTPM (protected, limit 5); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; thymus,PRH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"esophagus: 10.7 nTPM (protected, limit 5); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000231924,True,compatible,,True,0,2,partial,0.5,0.4,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,PSG1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000231989,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PPP1R2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,True,True,,,,unchanged
ENSG00000232030,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEB6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000232040,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,SCAND3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,False,False,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000232113,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TEX50,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000232423,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000232948,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB130A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000233050,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,DEFB130B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000233056,False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,9,80,unavailable,1.5,0.4,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ERVH48-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;incomplete_routine_rna,unchanged
ENSG00000233412,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5H15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000233436,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,BTBD18,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,True,True,,,,unchanged
ENSG00000233701,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRR23C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000233802,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TRIM49D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000233803,True,compatible,,True,0,2,partial,0.1,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,TSPY4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000233917,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,POTEB,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000234068,True,compatible,,True,0,2,partial,0.2,0.3,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen; thymus; tonsil,PAGE2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000234186,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,C16orf82,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000234278,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000234284,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,6.9,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF879,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000234289,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,3,partial,1.9,1.4,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,H2BC12L,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000234409,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,9.3,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,CCDC188,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000234414,True,compatible,,True,0,6,partial,0,0,,,41,not_established,not_triggered,,,RBMY1A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000234469,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CLDN34,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,True,True,,,,unchanged
ENSG00000234511,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.5,3,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,C5orf58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000234776,True,compatible,,True,0,80,unavailable,0,0.3,,,0,not_established,not_triggered,,,FREY1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000234828,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0.3,,,0,not_established,not_triggered,,,IQCM,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000235608,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,NKX1-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000235631,True,compatible,,True,0,80,unavailable,0.5,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,RNF148,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000235699,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CXorf51B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000236027,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PATE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000236032,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.2,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,OR5H14,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000236126,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000236362,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,1.7,8.3,"stomach: 8.3 nTPM (protected, limit 7.5); retina: 1.7 nTPM (vital, limit 1)",,45,not_established,not_triggered,,,GAGE12F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,False,False,"stomach: 8.3 nTPM (protected, limit 7.5); retina: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000236371,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000236396,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SLC35G4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000236424,True,compatible,,True,0,1,partial,0,0.1,,,48,not_established,not_triggered,,,TSPY10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000236446,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47B1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000236737,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,2.5,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,GAGE12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000236761,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,CTAGE9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000236980,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CIMIP7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000237136,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,C4orf51,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000237247,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MBD3L5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000237452,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,MEIOSIN,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000237521,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR7E24,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000237524,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,TEX51,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,True,True,,,,unchanged
ENSG00000237671,True,compatible,,True,0,4,partial,0,0,,,45,not_established,not_triggered,,,GAGE12C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000237957,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000238074,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,9,2,partial,0,0.2,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,TSPY9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,False,False,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),positive_ihc_outside_permitted;incomplete_routine_rna,unchanged
ENSG00000238083,False,excluded,positive_ihc_outside_permitted,True,0,9,partial,0.7,0.6,,small intestine / enterocytes - Gradient: Ascending (Supported),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,LRRC37A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,small intestine / enterocytes - Gradient: Ascending (Supported),positive_ihc_outside_permitted,unchanged
ENSG00000238205,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MPC1L,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000238269,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,4,0.6,"bone marrow: 4 nTPM (vital, limit 3)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PAGE2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"bone marrow: 4 nTPM (vital, limit 3)",,rna_above_tissue_ceiling,unchanged
ENSG00000239306,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,5,partial,49.1,33,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 5); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 5); stomach: 29.2 nTPM (protected, limit 5); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 5); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 5); thyroid gland: 27.6 nTPM (protected, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (protected, limit 5); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 5); parathyroid gland: 16.9 nTPM (protected, limit 5); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,RBM14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 5); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 5); stomach: 29.2 nTPM (protected, limit 5); skeletal muscle: 28.6 nTPM (vital, limit 1); choroid plexus: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 5); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 5); thyroid gland: 27.6 nTPM (protected, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (protected, limit 5); appendix: 24.3 nTPM (protected, limit 5); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 5); parathyroid gland: 16.9 nTPM (protected, limit 5); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 5); gallbladder: 10.3 nTPM (protected, limit 5)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000239388,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,27.1,17.3,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ASB14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000239389,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,1.8,3.4,"cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,PCDHA13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000239590,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR1J4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000239605,True,compatible,,True,0,4,partial,0.1,0.2,,,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,STPG4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000239620,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRR20G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,False,False,,,incomplete_routine_rna,unchanged
ENSG00000239704,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,2,partial,30.1,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (protected, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 5); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); esophagus: 6.5 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,CDRT4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (protected, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 5); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 5); esophagus: 6.5 nTPM (protected, limit 5); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 5); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000239789,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,4,partial,31.7,31.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 5); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 5); colon: 12.6 nTPM (protected, limit 5); hypothalamus: 12.5 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 5); adipose tissue: 9.3 nTPM (protected, limit 5); parathyroid gland: 9.3 nTPM (protected, limit 5); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); thyroid gland: 7.9 nTPM (protected, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,MRPS17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 5); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 5); colon: 12.6 nTPM (protected, limit 5); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 5); urinary bladder: 10.6 nTPM (protected, limit 5); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 5); parathyroid gland: 9.3 nTPM (protected, limit 5); adipose tissue: 9.3 nTPM (protected, limit 5); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 5); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); thyroid gland: 7.9 nTPM (protected, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); appendix: 7.5 nTPM (protected, limit 5); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000239810,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000239886,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP9-2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000239887,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,21.4,9.4,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 5); stomach: 8.4 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,C1orf226,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 5); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 5); stomach: 8.4 nTPM (protected, limit 5); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); appendix / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000240021,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.8,1.4,"retina: 1.5 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TEX35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"retina: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000240204,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10,6.2,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SMKR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,False,False,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000240303,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,12,partial,100.5,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); adipose tissue: 15.6 nTPM (protected, limit 10); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 5); bone marrow: 7.7 nTPM (vital, limit 5); colon: 7.4 nTPM (protected, limit 5); adrenal gland: 7.4 nTPM (vital, limit 5); smooth muscle: 6.1 nTPM (vital, limit 5); lung: 5.6 nTPM (vital, limit 5); spinal cord: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ACAD11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); adipose tissue: 15.6 nTPM (protected, limit 10); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 5); bone marrow: 7.7 nTPM (vital, limit 5); colon: 7.4 nTPM (protected, limit 5); adrenal gland: 7.4 nTPM (vital, limit 5); smooth muscle: 6.1 nTPM (vital, limit 5); lung: 5.6 nTPM (vital, limit 5); spinal cord: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1)",appendix / enterocytes - Microvilli: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000240445,False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,9,80,unavailable,2.2,1.7,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,FOXO3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;incomplete_routine_rna,unchanged
ENSG00000240563,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,5.2,"colon: 5.2 nTPM (protected, limit 5); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,L1TD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,False,False,"colon: 5.2 nTPM (protected, limit 5); lung: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000240682,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,50.4,31.2,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 5); esophagus: 21.5 nTPM (protected, limit 5); colon: 20.9 nTPM (protected, limit 5); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (protected, limit 5); urinary bladder: 17.7 nTPM (protected, limit 5); rectum: 16.3 nTPM (protected, limit 5); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); thyroid gland: 14.4 nTPM (protected, limit 5); stomach: 14.4 nTPM (protected, limit 5); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); spinal cord: 10.8 nTPM (vital, limit 1); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ISY1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 5); esophagus: 21.5 nTPM (protected, limit 5); colon: 20.9 nTPM (protected, limit 5); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); appendix: 18.3 nTPM (protected, limit 5); adipose tissue: 18.1 nTPM (protected, limit 5); urinary bladder: 17.7 nTPM (protected, limit 5); gallbladder: 16.7 nTPM (protected, limit 5); rectum: 16.3 nTPM (protected, limit 5); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); thyroid gland: 14.4 nTPM (protected, limit 5); stomach: 14.4 nTPM (protected, limit 5); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 5); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000240720,True,compatible,,True,0,4,partial,0.4,0.1,,,44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,LRRD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000240747,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.3,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.5 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,KRBOX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (protected, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.5 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000241128,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR14A2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000241149,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,ZNF722,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,True,True,,,,unchanged
ENSG00000241233,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.8,0.5,"kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,KRTAP5-8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"kidney: 5.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000241258,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,36.7,20.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 5); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (protected, limit 5); esophagus: 19.3 nTPM (protected, limit 5); rectum: 18.9 nTPM (protected, limit 5); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 5); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); urinary bladder: 15.9 nTPM (protected, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); adipose tissue: 13 nTPM (protected, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,CRCP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 5); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (protected, limit 5); esophagus: 19.3 nTPM (protected, limit 5); rectum: 18.9 nTPM (protected, limit 5); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 5); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 5); urinary bladder: 15.9 nTPM (protected, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); appendix: 13.4 nTPM (protected, limit 5); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 5); adipose tissue: 13 nTPM (protected, limit 5); gallbladder: 12.7 nTPM (protected, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); appendix / lymphoid tissue: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); gallbladder / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000241476,True,compatible,,True,0,2,partial,0,0.2,,,47,not_established,not_triggered,,,SSX2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000242220,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,3,partial,18.4,1.1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TCP10L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,False,False,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000242221,True,compatible,,True,0,80,unavailable,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,PSG2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000242362,True,compatible,,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47A2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000242389,True,compatible,,True,0,6,partial,0,0,,,41,not_established,not_triggered,,,RBMY1E,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000242441,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,8.4,"colon: 8.4 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,GTF2A1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"colon: 8.4 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000242715,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.8,1.8,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CCDC169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,False,False,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000242852,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF709,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000242875,True,compatible,,True,0,6,partial,0,0,,,41,not_established,not_triggered,,,RBMY1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000242950,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.7,1.2,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ERVW-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Gong 2021;Loriot 2025,False,False,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000243073,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000243130,True,compatible,,True,0,1,partial,0.5,0,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,PSG11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000243137,False,excluded,rna_above_tissue_ceiling,True,0,2,partial,1,53.8,"parathyroid gland: 53.8 nTPM (protected, limit 7.5)",,46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,PSG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"parathyroid gland: 53.8 nTPM (protected, limit 7.5)",,rna_above_tissue_ceiling,unchanged
ENSG00000243543,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.3,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,WFDC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,False,False,"lung: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000243667,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,11,9.5,"skeletal muscle: 11 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 5); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (protected, limit 5); rectum: 7.7 nTPM (protected, limit 5); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 5); esophagus: 6.8 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 5); stomach: 5.8 nTPM (protected, limit 5); adipose tissue: 5.8 nTPM (protected, limit 5); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,DNAAF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 11 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 5); choroid plexus: 8.9 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 5); thyroid gland: 8.1 nTPM (protected, limit 5); rectum: 7.7 nTPM (protected, limit 5); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 5); esophagus: 6.8 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); appendix: 6.4 nTPM (protected, limit 5); duodenum: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 5); stomach: 5.8 nTPM (protected, limit 5); adipose tissue: 5.8 nTPM (protected, limit 5); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); gallbladder: 5.1 nTPM (protected, limit 5); cerebral cortex: 5.1 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000243710,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,5,partial,13.6,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; thymus; tonsil,CFAP57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000243729,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR5V1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000243978,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,1.2,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,45,not_established,not_triggered,,,RTL9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000244057,True,compatible,,True,0,80,unavailable,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,LCE3C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000244219,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,3.4,3.3,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TMEM225B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000244234,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,9,5,partial,0,0.2,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,GMCL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),positive_ihc_outside_permitted;incomplete_routine_rna,unchanged
ENSG00000244395,True,compatible,,True,0,4,partial,0,0,,,43,not_established,not_triggered,,,RBMY1D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000244476,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,0.6,7.2,"parathyroid gland: 7.2 nTPM (protected, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; thymus,ERVFRD-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"parathyroid gland: 7.2 nTPM (protected, limit 5)",,rna_above_tissue_ceiling,unchanged
ENSG00000244588,True,compatible,,True,0,5,partial,0.8,0.1,,,44,not_established,required,lymphatic_and_immune_function_review,lymph node,RAD21L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000244624,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP20-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000244687,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,84.8,69.2,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 5); tongue: 68.2 nTPM (protected, limit 5); colon: 67.1 nTPM (protected, limit 5); lymph node: 66.8 nTPM (protected, limit 5); urinary bladder: 65.3 nTPM (protected, limit 5); pancreas: 62.7 nTPM (vital, limit 1); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 5); adipose tissue: 59.1 nTPM (protected, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 5); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (protected, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,UBE2V1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 5); tongue: 68.2 nTPM (protected, limit 5); colon: 67.1 nTPM (protected, limit 5); lymph node: 66.8 nTPM (protected, limit 5); urinary bladder: 65.3 nTPM (protected, limit 5); pancreas: 62.7 nTPM (vital, limit 1); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 5); adipose tissue: 59.1 nTPM (protected, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); appendix: 55.3 nTPM (protected, limit 5); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 5); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (protected, limit 5); gallbladder: 46.4 nTPM (protected, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000247077,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,4,partial,32,23.1,"skeletal muscle: 32 nTPM (vital, limit 5); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 5); lymph node: 20.9 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 5); cerebral cortex: 17.7 nTPM (vital, limit 1); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 5); urinary bladder: 15 nTPM (protected, limit 5); duodenum: 14.8 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); small intestine: 12.8 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); rectum: 11.2 nTPM (protected, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 10); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,PGAM5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"skeletal muscle: 32 nTPM (vital, limit 5); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 5); lymph node: 20.9 nTPM (protected, limit 5); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 5); cerebral cortex: 17.7 nTPM (vital, limit 1); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); appendix: 16.4 nTPM (protected, limit 5); colon: 16 nTPM (protected, limit 5); urinary bladder: 15 nTPM (protected, limit 5); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 5); small intestine: 12.8 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); rectum: 11.2 nTPM (protected, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (protected, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 10); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); gallbladder: 8.7 nTPM (protected, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: Medium (Enhanced); appendix / lymphoid tissue: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); gallbladder / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000247746,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,3.5,5.4,"parathyroid gland: 5.4 nTPM (protected, limit 5); thyroid gland: 5.1 nTPM (protected, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,USP51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 5.4 nTPM (protected, limit 5); thyroid gland: 5.1 nTPM (protected, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: High (Uncertain); appendix / lymphoid tissue: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); gallbladder / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000248098,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,107.3,117.2,"tongue: 117.2 nTPM (protected, limit 5); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 5); parathyroid gland: 54.4 nTPM (protected, limit 5); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 5); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (protected, limit 5); adipose tissue: 32.6 nTPM (protected, limit 5); bone marrow: 32 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 5); midbrain: 23.8 nTPM (vital, limit 1); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 5); colon: 20.3 nTPM (protected, limit 5); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,BCKDHA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 117.2 nTPM (protected, limit 5); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 5); parathyroid gland: 54.4 nTPM (protected, limit 5); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 5); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (protected, limit 5); adipose tissue: 32.6 nTPM (protected, limit 5); bone marrow: 32 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 5); midbrain: 23.8 nTPM (vital, limit 1); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 5); colon: 20.3 nTPM (protected, limit 5); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); appendix: 18.7 nTPM (protected, limit 5); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); gallbladder: 14.8 nTPM (protected, limit 5); rectum: 14.5 nTPM (protected, limit 5); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000248099,True,compatible,,True,0,2,partial,1.8,2.8,,,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,INSL3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000248383,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,28.8,"parathyroid gland: 28.8 nTPM (protected, limit 5); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,PCDHAC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,False,False,"parathyroid gland: 28.8 nTPM (protected, limit 5); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000248483,False,excluded,positive_ihc_outside_permitted,True,0,4,partial,1,0.2,,kidney / cells in tubules: Low (Enhanced),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,POU5F2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,False,False,,kidney / cells in tubules: Low (Enhanced),positive_ihc_outside_permitted,unchanged
ENSG00000248767,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FOXL3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000248905,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,13,partial,29.1,7.7,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,FMN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 5); colon: 5.5 nTPM (protected, limit 5); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); appendix / glandular cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000249139,True,compatible,existing_nomination_or_manual_review,True,0,1,partial,0.1,0.1,,,47,not_established,not_triggered,,,EPPIN-WFDC6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000249471,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.5,2.9,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF324B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000249481,True,compatible,,True,0,4,partial,1,0.1,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; thymus,SPATS1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000249581,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,CLRN2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000249693,True,compatible,,True,0,80,unavailable,0.5,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,SPMAP2L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935,Chang 2019;Carter 2023,True,True,,,,unchanged
ENSG00000249709,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,7.4,7.7,"tongue: 7.7 nTPM (protected, limit 5); thyroid gland: 7.7 nTPM (protected, limit 5); kidney: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); rectum: 7 nTPM (protected, limit 5); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); stomach: 6.6 nTPM (protected, limit 5); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF564,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 7.7 nTPM (protected, limit 5); thyroid gland: 7.7 nTPM (protected, limit 5); kidney: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 5); colon: 7.2 nTPM (protected, limit 5); rectum: 7 nTPM (protected, limit 5); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 5); stomach: 6.6 nTPM (protected, limit 5); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 5); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000249861,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,LGALS16,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000249884,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,4.1,0.9,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RNF103-CHMP3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000249961,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.4,0.3,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,TERB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,"bone marrow: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000250120,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,PCDHA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000250312,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,4.6,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF718,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000250423,True,compatible,,True,0,3,partial,1.3,0,,,46,not_established,not_triggered,,,KIAA1210,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,True,True,,,,unchanged
ENSG00000250565,False,excluded,rna_above_tissue_ceiling,True,0,8,partial,4.2,1.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ATP6V1E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000250709,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.4,0.3,,,0,not_established,not_triggered,,,CCDC169-SOHLH2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000250719,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,P3R3URF,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000250741,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,NT5C1B-RDH14,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000250803,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ZNF475,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000251258,True,compatible,,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,RFPL4B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000251493,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.7,1.9,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,FOXD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000251503,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,8.3,1.5,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CENPS-CORT,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000253506,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,1.1,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,NACA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;da Silva 2017,False,False,"pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000253910,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.6,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHGB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000254221,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,12.4,2.1,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,PCDHGB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000254535,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.3,5.2,"parathyroid gland: 5.2 nTPM (protected, limit 5); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PABPC4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"parathyroid gland: 5.2 nTPM (protected, limit 5); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000254726,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.1,0.7,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,MEX3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000255150,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,6.4,6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,EID3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,False,False,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000255181,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,CCDC166,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000255223,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0.1,,,0,not_established,not_triggered,,,OR5M11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000255251,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRR23D1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000255298,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR8G5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000255346,True,compatible,,True,0,80,unavailable,0.8,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,NOX5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000255359,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CCDC179,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000255378,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,PRR23D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000255408,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,PCDHA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000255529,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,34.7,37.4,"tongue: 37.4 nTPM (protected, limit 5); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 5); spinal cord: 24.3 nTPM (vital, limit 1); midbrain: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (protected, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 5); adipose tissue: 18.7 nTPM (protected, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 5); stomach: 14.6 nTPM (protected, limit 5); urinary bladder: 14.6 nTPM (protected, limit 5); rectum: 14.6 nTPM (protected, limit 5); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,POLR2M,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"tongue: 37.4 nTPM (protected, limit 5); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 5); spinal cord: 24.3 nTPM (vital, limit 1); midbrain: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (protected, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 5); adipose tissue: 18.7 nTPM (protected, limit 5); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); gallbladder: 15.6 nTPM (protected, limit 5); colon: 15 nTPM (protected, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 5); rectum: 14.6 nTPM (protected, limit 5); stomach: 14.6 nTPM (protected, limit 5); urinary bladder: 14.6 nTPM (protected, limit 5); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); appendix: 10.3 nTPM (protected, limit 5); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000256061,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,3,partial,28.7,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 5); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,DNAAF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (protected, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 5); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); gallbladder / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000256223,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,44.1,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (protected, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 5); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 5); kidney: 10.6 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 5); liver: 10.4 nTPM (vital, limit 1); stomach: 10.2 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (protected, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 5); rectum: 6 nTPM (protected, limit 5); lymph node: 5.8 nTPM (protected, limit 5); esophagus: 5.8 nTPM (protected, limit 5); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (protected, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 5); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 5); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 5); stomach: 10.2 nTPM (protected, limit 5); gallbladder: 9.9 nTPM (protected, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (protected, limit 5); tongue: 6.1 nTPM (protected, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 5); esophagus: 5.8 nTPM (protected, limit 5); lymph node: 5.8 nTPM (protected, limit 5); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000256294,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,6.7,4.3,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF225,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000256453,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3,0.6,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,DND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000256660,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,5.4,0.4,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,CLEC12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,False,False,"bone marrow: 5.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000256980,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,8.1,0.1,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; thymus; tonsil,KHDC1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000257218,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,36.7,12.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 5); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 5); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); amygdala: 9.9 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 5); colon: 9.8 nTPM (protected, limit 5); adipose tissue: 9.7 nTPM (protected, limit 5); urinary bladder: 9.6 nTPM (protected, limit 5); stomach: 9.3 nTPM (protected, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,GATC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 5); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (protected, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 5); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 5); small intestine: 9.9 nTPM (vital, limit 1); amygdala: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 5); adipose tissue: 9.7 nTPM (protected, limit 5); urinary bladder: 9.6 nTPM (protected, limit 5); stomach: 9.3 nTPM (protected, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 5); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); appendix: 8.1 nTPM (protected, limit 5); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 5); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); gallbladder: 7 nTPM (protected, limit 5); heart muscle: 6.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000257987,True,compatible,,True,0,80,unavailable,0.2,1.1,,,0,not_established,not_triggered,,,SPMIP11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,True,True,,,,unchanged
ENSG00000258223,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,PRSS58,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000258289,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,80,51.8,"skeletal muscle: 80 nTPM (vital, limit 1); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 5); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (protected, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 5); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 5); lymph node: 41.8 nTPM (protected, limit 5); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 5); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 5); kidney: 33.1 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 5); stomach: 32.7 nTPM (protected, limit 5); amygdala: 32.7 nTPM (vital, limit 1); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (protected, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,CHURC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 80 nTPM (vital, limit 1); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 5); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (protected, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 5); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 5); lymph node: 41.8 nTPM (protected, limit 5); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); appendix: 37.7 nTPM (protected, limit 5); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 5); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 5); kidney: 33.1 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 5); stomach: 32.7 nTPM (protected, limit 5); amygdala: 32.7 nTPM (vital, limit 1); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (protected, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); gallbladder: 30.4 nTPM (protected, limit 5); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); gallbladder / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000258366,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,14.5,8.3,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 5); thyroid gland: 7.6 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RTEL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 5); thyroid gland: 7.6 nTPM (protected, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 5); urinary bladder: 6.3 nTPM (protected, limit 5); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000258405,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF578,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000258436,True,compatible,,True,0,4,partial,0.2,0,,,43,not_established,not_triggered,,,RNASE12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000258597,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,SERPINA2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000258713,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,C20orf141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,False,False,"retina: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000258992,True,compatible,,True,0,1,partial,0,0,,,48,not_established,not_triggered,,,TSPY1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000259060,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,ENSG00000259060,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,True,True,,,,unchanged
ENSG00000259224,True,compatible,,True,0,80,unavailable,0.4,0,,,0,not_established,not_triggered,,,SLC35G6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,True,True,,,,unchanged
ENSG00000259316,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,ENSG00000259316,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged
ENSG00000259571,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,BLID,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000260286,True,compatible,,True,0,80,unavailable,1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ARMH2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,True,True,,,,unchanged
ENSG00000260287,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,2,partial,2.7,1.2,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,TBC1D3G,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000260456,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,10,partial,6.8,3,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,C16orf95,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,False,False,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",appendix / endocrine cells: High (Supported); colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000260596,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.3,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; thymus,DUX4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000260734,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TLE7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000261341,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.8,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,SMIM47,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000261509,True,compatible,,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,TP53TG3B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,True,True,,,,unchanged
ENSG00000261649,True,compatible,,True,0,80,unavailable,0.4,0.1,,,0,not_established,not_triggered,,,GOLGA6L7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,True,True,,,,unchanged
ENSG00000261739,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.7,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,GOLGA8S,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000261873,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,10.5,0,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,SMIM36,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"retina: 10.5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000261949,True,compatible,,True,0,80,unavailable,0.6,0,,,0,not_established,not_triggered,,,GFY,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,True,True,,,,unchanged
ENSG00000262246,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,68.7,23.7,"bone marrow: 68.7 nTPM (vital, limit 1); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 5); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 5); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (protected, limit 5); stomach: 14.9 nTPM (protected, limit 5); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 5); thyroid gland: 14 nTPM (protected, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); cerebellum: 12.4 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,CORO7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 68.7 nTPM (vital, limit 1); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 5); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 5); cerebral cortex: 17.5 nTPM (vital, limit 1); appendix: 16.3 nTPM (protected, limit 5); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (protected, limit 5); stomach: 14.9 nTPM (protected, limit 5); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 5); thyroid gland: 14 nTPM (protected, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); cerebellum: 12.4 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 5); pancreas: 10.5 nTPM (vital, limit 1); gallbladder: 8.7 nTPM (protected, limit 5); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",appendix / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); gallbladder / glandular cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000262576,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.3,2.2,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,PCDHGA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000262874,False,excluded,positive_ihc_outside_permitted,True,0,1,partial,0.6,0.2,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,C19orf84,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,False,False,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),positive_ihc_outside_permitted,unchanged
ENSG00000266826,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,IGBP1C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000267631,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,0,2,partial,4.1,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),47,not_established,not_triggered,,,CGB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted,unchanged
ENSG00000267855,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,6,partial,237,232.8,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 5); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 5); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 5); stomach: 53.2 nTPM (protected, limit 5); colon: 45.2 nTPM (protected, limit 5); spinal cord: 43.9 nTPM (vital, limit 1); thyroid gland: 40.1 nTPM (protected, limit 5); adipose tissue: 38.2 nTPM (protected, limit 10); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 5); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 5); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); lymph node: 28.8 nTPM (protected, limit 5); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,NDUFA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 5); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 5); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 5); stomach: 53.2 nTPM (protected, limit 5); colon: 45.2 nTPM (protected, limit 5); spinal cord: 43.9 nTPM (vital, limit 1); thyroid gland: 40.1 nTPM (protected, limit 5); adipose tissue: 38.2 nTPM (protected, limit 10); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 5); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 5); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); lymph node: 28.8 nTPM (protected, limit 5); gallbladder: 24.1 nTPM (protected, limit 5); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1); appendix: 19.2 nTPM (protected, limit 5)",adrenal gland / glandular cells: High (Enhanced); appendix / glandular cells: High (Enhanced); appendix / lymphoid tissue: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); gallbladder / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000267978,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,MAGEA9B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000268009,True,compatible,,True,0,3,partial,0.2,0.1,,,45,not_established,not_triggered,,,SSX4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000268223,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ARL14EPL,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000268447,True,compatible,,True,0,2,partial,0.1,0.3,,,48,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SSX2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000268480,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,80,unavailable,0.8,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,NFILZ,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000268606,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,MAGEA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000268629,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,TEX13A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000268651,True,compatible,,True,0,4,partial,0,0,,,45,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CTAG1A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000268696,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0.1,0.2,,,0,not_established,not_triggered,,,ZNF723,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,False,False,,,incomplete_routine_rna,unchanged
ENSG00000268738,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.7,2,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,HSFX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000268902,True,compatible,,True,0,80,unavailable,0.1,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,CSAG2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,True,True,,,,unchanged
ENSG00000268916,True,compatible,,True,0,80,unavailable,0.4,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; thymus; tonsil,CSAG3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,True,True,,,,unchanged
ENSG00000268940,True,compatible,existing_nomination_or_manual_review,True,0,3,partial,0.8,0,,,46,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,CT45A1,current_adaptive,False,True,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000268964,True,compatible,,True,0,80,unavailable,0.5,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ERVV-2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,True,True,,,,unchanged
ENSG00000268988,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPANXN2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000268994,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,FAM236B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"retina: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000269058,True,compatible,,True,0,2,partial,0.1,0.1,,,46,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,CALR3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000269096,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,4,partial,2.3,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),45,not_established,not_triggered,,,CT45A3,current_adaptive,False,True,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,False,False,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000269405,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,0.1,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,NXF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Loriot 2025,False,False,"pituitary gland: 3.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000269437,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.4,0.1,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,NXF2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"pituitary gland: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000269502,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,DMRTC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000269526,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.7,0.2,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,ERVV-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"kidney: 1.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000269586,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,1.4,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,46,not_established,not_triggered,,,CT45A10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,False,False,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000269791,True,compatible,,True,0,2,partial,0.1,0,,,45,not_established,not_triggered,,,SSX4B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000270379,True,compatible,,True,0,80,unavailable,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,HEATR9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000270601,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000270806,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen; thymus,C17orf50,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,False,False,"basal ganglia: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000270946,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,3,unreliable,0.1,0,,heart muscle / cardiomyocytes: Low (Supported),46,not_established,not_triggered,,,CT45A9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,False,False,,heart muscle / cardiomyocytes: Low (Supported),positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000271321,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,CTAGE6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000271449,True,compatible,,True,0,3,partial,0,0,,,46,not_established,not_triggered,,,CT45A2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000272804,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,KRTAP10-7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000272968,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,RBAK-RBAKDN,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000273111,True,compatible,,True,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,LYPD4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000273313,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,RBAKDN,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000273696,True,compatible,,True,0,3,partial,0.1,0.1,,,46,not_established,not_triggered,,,CT45A7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,True,True,,,,unchanged
ENSG00000273976,True,compatible,,True,0,80,unavailable,0.5,0,,,0,not_established,not_triggered,,,GOLGA6L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000274102,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4M2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000274183,True,compatible,,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,H2AB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000274209,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ANTXRL,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000274274,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,1.4,0,"retina: 1.4 nTPM (vital, limit 1)",,45,not_established,not_triggered,,,GAGE13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,False,False,"retina: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000274391,True,compatible,,True,0,1,partial,0,0.1,,,48,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,TPTE,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Bruggeman 2018;Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000274419,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,0,2,partial,7,4,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); liver: 3.3 nTPM (vital, limit 2); adrenal gland: 3.1 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); kidney: 2.4 nTPM (vital, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,TBC1D3D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); liver: 3.3 nTPM (vital, limit 2); adrenal gland: 3.1 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); kidney: 2.4 nTPM (vital, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",gallbladder / glandular cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,unchanged
ENSG00000274600,True,compatible,existing_nomination_or_manual_review,True,0,7,partial,0.2,0.3,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,RIMBP3B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000274618,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,4,partial,0.8,0.2,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,H4C6,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,adipose tissue / adipocytes: Low (Supported); appendix / glandular cells: Medium (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000274764,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF27,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000274933,True,compatible,existing_nomination_or_manual_review,True,0,4,partial,0.9,0.3,,,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TBC1D3I,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000275004,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,3.2,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF280B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,False,False,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000275111,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,2.9,3.7,"heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000275113,False,excluded,rna_above_tissue_ceiling,True,0,4,partial,2.4,14.9,"stomach: 14.9 nTPM (protected, limit 5); retina: 2.4 nTPM (vital, limit 1)",,45,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,GAGE2E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,False,False,"stomach: 14.9 nTPM (protected, limit 5); retina: 2.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000275489,True,compatible,,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,SPMAP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000275520,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.5,1.9,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,FAM236A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,False,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000275722,True,compatible,,True,0,1,partial,0.3,0.2,,,48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,LYZL6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000275774,False,excluded,insufficient_positive_evidence_inside,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,HNRNPCL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside,unchanged
ENSG00000275793,True,compatible,,True,0,7,partial,0.3,0.7,,,43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,RIMBP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,True,True,,,,unchanged
ENSG00000275954,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,TBC1D3F,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000275969,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31A3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000276040,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31A7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000276234,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,10.2,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,TADA2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (protected, limit 5); small intestine: 5.2 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000276240,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,OR4E1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000276410,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,0,4,partial,1,0.2,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,H2BC3,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); appendix / glandular cells: High (Supported); appendix / lymphoid tissue: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); gallbladder / glandular cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,unchanged
ENSG00000276430,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,1.6,29.3,"esophagus: 29.3 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; thymus; tonsil,FAM25C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,False,False,"esophagus: 29.3 nTPM (protected, limit 5); small intestine: 1.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000276581,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPATA31A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,True,True,,,,unchanged
ENSG00000276747,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PADI6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000276950,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GSTT4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000277322,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,GOLGA6L6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,True,True,,,,unchanged
ENSG00000277462,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,0,0,routine_complete,2.2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ZNF670,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); appendix / glandular cells: Low (Uncertain); appendix / lymphoid tissue: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); gallbladder / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,unchanged
ENSG00000277535,True,compatible,existing_nomination_or_manual_review,True,0,4,partial,0,0,,,44,not_established,not_triggered,,,CT47C1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000277745,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,H2AB3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000277865,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,GOLGA6L22,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000278057,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,TEX28,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000278085,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,0,3,unreliable,0.1,0,,heart muscle / cardiomyocytes: Low (Supported),46,not_established,not_triggered,,,CT45A8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,False,False,,heart muscle / cardiomyocytes: Low (Supported),positive_ihc_outside_permitted;reviewed_unreliable_ihc,unchanged
ENSG00000278289,False,excluded,rna_above_tissue_ceiling,True,0,3,partial,3.9,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,46,not_established,not_triggered,,,CT45A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,False,False,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000278318,False,excluded,rna_above_tissue_ceiling,True,0,80,unavailable,4.3,2.6,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ZNF229,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling,unchanged
ENSG00000278522,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,POTEB3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000278685,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,IQCA1L,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000279169,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PRAMEF13,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000279408,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR4N4C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000282419,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TEX13D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000282815,True,compatible,,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,TEX13C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,True,True,,,,unchanged
ENSG00000283093,False,excluded,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,False,0,80,unavailable,4.7,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,CENPVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,False,False,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;insufficient_positive_evidence_inside,unchanged
ENSG00000283205,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000283205,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000283268,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.1,0.5,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,TEX54,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"pituitary gland: 1.1 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000283434,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,CSNK2A2IP,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000283439,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,SPEM3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000283463,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,2.7,0.1,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; thymus,HSFX4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"adrenal gland: 2.7 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000283516,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0,,,0,not_established,not_triggered,,,LITAFD,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000283594,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,FAM236C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000283599,True,compatible,,True,0,80,unavailable,0.2,0,,,0,not_established,not_triggered,,,ENSG00000283599,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Gong 2021;Carter 2023,True,True,,,,unchanged
ENSG00000283697,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,0,80,unavailable,1.2,0,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,thymus,HSFX3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,"adrenal gland: 1.2 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;existing_nomination_or_manual_review,unchanged
ENSG00000283758,False,excluded,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,False,0,80,unavailable,0,0,,,0,not_established,not_triggered,,,PMIS2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,False,,,insufficient_positive_evidence_inside;existing_nomination_or_manual_review,unchanged
ENSG00000284188,True,compatible,existing_nomination_or_manual_review,True,0,80,unavailable,0.3,0.1,,,0,not_established,not_triggered,,,C1orf202,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,False,True,,,existing_nomination_or_manual_review,unchanged
ENSG00000284609,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR8B3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000284680,False,unresolved,incomplete_routine_rna,True,9,80,unavailable,0,0,,,0,not_established,not_triggered,,,OR8B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,False,False,,,incomplete_routine_rna,unchanged
ENSG00000284701,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,9,4,partial,0,0,,,43,not_established,not_triggered,,,TMEM247,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000284723,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,False,9,80,unavailable,0.1,0,,,0,not_established,not_triggered,,,OR8S1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna;existing_nomination_or_manual_review,unchanged
ENSG00000284770,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,9,5,partial,8.4,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),43,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,TBCE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,False,False,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (protected, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); appendix / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); gallbladder / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,unchanged
ENSG00000285077,False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,9,80,unavailable,5,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ARHGAP11B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,"bone marrow: 5 nTPM (vital, limit 1)",,rna_above_tissue_ceiling;incomplete_routine_rna,unchanged
ENSG00000293137,False,excluded,insufficient_positive_evidence_inside;incomplete_routine_rna,False,50,80,unavailable,,,,,0,not_established,not_triggered,,,MSL3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,,,insufficient_positive_evidence_inside;incomplete_routine_rna,unchanged