@prefix herbkg: . @prefix owl: . @prefix rdf: . @prefix rdfs: . @prefix skos: . @prefix dcterms: . @prefix prov: . @prefix xsd: . ################################################################# # Ontology metadata (schema/TBox only) ################################################################# herbkg:TCMModernMedicineOntology a owl:Ontology ; dcterms:title "Integrated TCM–Modern Medicine Ontology Schema"@en ; dcterms:description "An OWL 2 DL ontology schema for integrating traditional Chinese medicine and modern biomedical knowledge. This release contains schema-level definitions only (TBox), without instance data."@en ; dcterms:creator "Institute of Literature Research, Nanjing University of Chinese Medicine"@en ; owl:versionInfo "v1.3" ; rdfs:comment "v1.3 adopts the permanent namespace https://w3id.org/herbkg/ with the prefix herbkg:. v1.2 completed the object-property inventory so that the schema matches the 32 fine-grained relation types reported in the accompanying publication, and replaced multi-valued rdfs:domain declarations with explicit owl:unionOf class expressions."@en ; dcterms:license . ################################################################# # Classes (top-level) ################################################################# herbkg:Herb a owl:Class ; rdfs:label "Herb"@en, "中草药"@zh ; rdfs:comment "Medicinal plants used in traditional Chinese medicine for disease treatment."@en ; rdfs:comment "药用植物,可对疾病有治疗作用。"@zh . herbkg:Formula a owl:Class ; rdfs:label "Formula"@en, "方剂"@zh ; rdfs:comment "A TCM prescription composed of multiple herbs to achieve therapeutic effects."@en ; rdfs:comment "多个中草药组成的中药配伍,以多味中草药的集合实现疾病治疗。"@zh . herbkg:Function a owl:Class ; rdfs:label "Function"@en, "功效"@zh ; rdfs:comment "Therapeutic function (treatment principle) of herbs or formulas that acts on specific TCM syndromic patterns."@en ; rdfs:comment "中草药的治疗效用,也称为治法,可以作用于特定证候。"@zh . herbkg:Symptom a owl:Class ; rdfs:label "Symptom"@en, "证候"@zh ; rdfs:comment "A TCM syndromic pattern summarized from clinical manifestations obtained through the four diagnostic methods."@en ; rdfs:comment "通过四诊所获得的机体在疾病某阶段反映出的一系列症状的归纳。"@zh . herbkg:Sign a owl:Class ; rdfs:label "Sign"@en, "症状"@zh ; rdfs:comment "An abnormal sensation or pathological change manifested by the patient."@en ; rdfs:comment "症状是患者身体表现出的异常感觉或病态变化。"@zh . herbkg:Disease a owl:Class ; rdfs:label "Disease"@en, "疾病"@zh ; rdfs:comment "A general super-class for disease entities."@en ; rdfs:comment "疾病概念的通用上位类。"@zh . herbkg:CMDisease a owl:Class ; rdfs:subClassOf herbkg:Disease ; rdfs:label "Disease (Chinese Medicine)"@en, "中医疾病"@zh ; rdfs:comment "Disease entities defined from the perspective of Chinese medicine, summarized by syndromic patterns, symptoms, signs, or abnormal behaviors."@en ; rdfs:comment "中医角度基于证候、症状、体征或行为异常等的归纳。"@zh . herbkg:MMDisease a owl:Class ; rdfs:subClassOf herbkg:Disease ; rdfs:label "Disease (Modern Medicine)"@en, "西医疾病"@zh ; rdfs:comment "Disease entities defined from the perspective of modern medicine, reflecting negative functional or structural abnormalities in the body."@en ; rdfs:comment "西医角度对于人体生命活动异常、功能或结构出现负面表现的归纳。"@zh . herbkg:Compound a owl:Class ; rdfs:label "Compound"@en, "化合物"@zh ; rdfs:comment "Chemical constituents isolated from herbs that can act on genes and modulate biological processes."@en ; rdfs:comment "中草药中分离出的化学成分,可以作用于基因,对其有调节作用。"@zh . herbkg:Gene a owl:Class ; rdfs:label "Gene"@en, "基因"@zh ; rdfs:comment "A DNA segment carrying hereditary information and associated with diseases."@en ; rdfs:comment "基因是带有遗传信息的DNA片段,与疾病具有一定关系。"@zh . ################################################################# # Reified association class and provenance-support classes # # Herb–Disease therapeutic associations are not asserted manually. They # are derived by ontology-guided path traversal and are reified so that # supporting evidence, evidence level, confidence, and provenance can be # attached to each individual association. ################################################################# herbkg:HerbDiseaseAssociation a owl:Class ; rdfs:label "Herb–Disease association"@en, "中草药—疾病关联"@zh ; rdfs:comment "A reified herb–disease therapeutic association derived by ontology-guided path traversal. Instances are produced downstream rather than asserted in this schema, and carry evidence, evidence level, and provenance annotations."@en . herbkg:Evidence a owl:Class ; rdfs:label "Evidence"@en, "证据"@zh ; rdfs:comment "A supporting evidence record for a derived association."@en . herbkg:EvidenceLevel a owl:Class ; rdfs:label "Evidence level"@en, "证据等级"@zh ; rdfs:comment "A qualitative confidence level assigned to a derived association. The controlled vocabulary comprises authoritative, multi-document, and single-document levels, in decreasing order of priority."@en . herbkg:SourceDocument a owl:Class ; rdfs:label "Source document"@en, "来源文献"@zh ; rdfs:comment "A document-level source, such as a PubMed or Wanfang abstract, from which an assertion was derived."@en . herbkg:Dataset a owl:Class ; rdfs:label "Dataset"@en, "数据集"@zh ; rdfs:comment "A source dataset, such as ICD-10, OMIM, or the Chinese Pharmacopoeia, from which records were retrieved."@en . herbkg:ICDCode a owl:Class ; rdfs:label "ICD-10 code"@en, "ICD-10编码"@zh ; rdfs:comment "An ICD-10 classification code used as a normalization anchor for modern medicine disease entities."@en . ################################################################# # SKOS concept-based category classes (as skos:Concept) ################################################################# skos:Concept a owl:Class . herbkg:HerbType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Herb type"@en, "草药类别"@zh ; rdfs:comment "Categories of herbs (e.g., exterior-releasing, heat-clearing)."@en ; rdfs:comment "指中草药的草药类别,如解表药、清热药等。"@zh . herbkg:Flavor a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Flavor"@en, "味"@zh ; rdfs:comment "Organoleptic flavor categories of herbs (e.g., sour, bitter, sweet, pungent, salty)."@en ; rdfs:comment "指中草药具有酸、苦、甘、辛、咸等味道。"@zh . herbkg:Nature a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Nature"@en, "性质"@zh ; rdfs:comment "TCM nature (property) categories of herbs (e.g., cold, hot, warm, cool)."@en ; rdfs:comment "指中草药具有寒、热、温、凉等药性。"@zh . herbkg:ChannelTropism a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Channel tropism"@en, "归经"@zh ; rdfs:comment "Meridian/channel tropism indicating targeted organs/meridians in TCM theory."@en ; rdfs:comment "指中草药对机体某些脏腑经络具有治疗作用。"@zh . herbkg:Toxicity a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Toxicity"@en, "毒性"@zh ; rdfs:comment "Toxicity degree of an herb."@en ; rdfs:comment "毒性是中草药的偏性,指有毒程度。"@zh . herbkg:FormulaType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Formula type"@en, "方剂类别"@zh ; rdfs:comment "Categories of formulas (e.g., warming-interior, wind-dispelling)."@en ; rdfs:comment "指方剂的类别,如温里剂、治风剂等。"@zh . herbkg:FunctionType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Function type"@en, "功效类别"@zh ; rdfs:comment "Categories of therapeutic functions (e.g., exterior-releasing, heat-clearing)."@en ; rdfs:comment "指功效的类别,如解表法、清热法等。"@zh . herbkg:SymptomType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Symptom type"@en, "证候类别"@zh ; rdfs:comment "Categories of TCM syndromic patterns (e.g., heart-system patterns, lung-system patterns)."@en ; rdfs:comment "指证候的类别,如心系证类、肺系证类等。"@zh . herbkg:SignType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Sign type"@en, "症状类别"@zh ; rdfs:comment "Categories of clinical signs/symptoms."@en ; rdfs:comment "指症状的类别。"@zh . herbkg:DiseaseType a owl:Class ; rdfs:subClassOf skos:Concept ; rdfs:label "Disease type"@en, "疾病类别"@zh ; rdfs:comment "Categories of diseases (e.g., dermatologic diseases, ophthalmic diseases)."@en ; rdfs:comment "指疾病的类别,如皮肤病类、眼病类等。"@zh . ################################################################# # Object Properties — TCM branch # # Note on domains: where a property applies to more than one class, the # domain is expressed as an owl:unionOf class expression. A comma-separated # rdfs:domain list would be read as an intersection, which would wrongly # require an individual to belong to every listed class at once. ################################################################# herbkg:hasFunction a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf ( herbkg:Herb herbkg:Formula ) ] ; rdfs:range herbkg:Function ; rdfs:label "has function"@en, "具有功效"@zh ; rdfs:comment "Links a herb or formula to its therapeutic function."@en . herbkg:hasEffectTo a owl:ObjectProperty ; rdfs:domain herbkg:Function ; rdfs:range herbkg:Symptom ; rdfs:label "has effect to"@en, "作用于证候"@zh ; rdfs:comment "Describes the effect of a therapeutic function on a TCM symptom (syndromic pattern)."@en . herbkg:hasPresentation a owl:ObjectProperty ; rdfs:domain herbkg:Symptom ; rdfs:range herbkg:Sign ; rdfs:label "has presentation"@en, "表现为"@zh ; rdfs:comment "Indicates that a TCM symptom is manifested as an observable clinical sign."@en . herbkg:treatsSymptom a owl:ObjectProperty ; rdfs:domain herbkg:Formula ; rdfs:range herbkg:Symptom ; rdfs:label "treats symptom"@en, "治疗证候"@zh ; rdfs:comment "Indicates that a formula is used to treat a specific TCM symptom."@en . herbkg:treatsSign a owl:ObjectProperty ; rdfs:domain herbkg:Formula ; rdfs:range herbkg:Sign ; rdfs:label "treats sign"@en, "治疗症状"@zh ; rdfs:comment "Indicates that a formula is used to treat a specific clinical sign."@en . herbkg:isHerbOf a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Formula ; rdfs:label "is herb of"@en, "组成方剂"@zh ; rdfs:comment "Specifies that a herb is a component of a formula."@en . herbkg:containsHerb a owl:ObjectProperty ; owl:inverseOf herbkg:isHerbOf ; rdfs:domain herbkg:Formula ; rdfs:range herbkg:Herb ; rdfs:label "contains herb"@en, "含有草药"@zh ; rdfs:comment "Indicates that a formula contains a specific herb. Declared as the inverse of isHerbOf."@en . herbkg:isSignOf a owl:ObjectProperty ; rdfs:domain herbkg:Sign ; rdfs:range herbkg:Disease ; rdfs:label "is sign of"@en, "为疾病之症状"@zh ; rdfs:comment "Indicates that a clinical sign is indicative of a disease. The range is the general Disease class because signs in the released subset are linked to both CMDisease and MMDisease entities."@en . ################################################################# # Object Properties — cross-paradigm therapeutic association # # These properties are defined here so that derived associations can be # typed and constrained. No instance of them is asserted in this schema; # instances are produced downstream by ontology-guided path traversal. ################################################################# herbkg:treatDisease a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf ( herbkg:Herb herbkg:Formula ) ] ; rdfs:range herbkg:Disease ; rdfs:label "treat disease"@en, "治疗疾病"@zh ; rdfs:comment "Indicates that a herb or formula is used to treat a disease. Instances are not asserted manually; they are derived by ontology-guided traversal of the herb–compound–gene–disease chain or its TCM-branch counterpart, and are reified as herbkg:HerbDiseaseAssociation individuals so that supporting evidence and provenance can be attached."@en . herbkg:associatedWith a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Disease ; rdfs:label "associated with"@en, "关联疾病"@zh ; rdfs:comment "Indicates a therapeutic association between a herb and a disease that is weaker than an explicit treatment claim. Instances are derived rather than asserted manually."@en . ################################################################# # Object Properties — modern medicine branch ################################################################# herbkg:hasCompound a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Compound ; rdfs:label "has compound"@en, "含有化合物"@zh ; rdfs:comment "Links a herb to its bioactive chemical compounds."@en . herbkg:associateGene a owl:ObjectProperty ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:Gene ; rdfs:label "associate gene"@en, "关联基因"@zh ; rdfs:comment "Associates a chemical compound with related genes."@en . herbkg:targets a owl:ObjectProperty ; rdfs:subPropertyOf herbkg:associateGene ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:Gene ; rdfs:label "targets"@en, "靶向"@zh ; rdfs:comment "Indicates that a compound targets a gene or its protein product. Specialization of associateGene."@en . herbkg:modulates a owl:ObjectProperty ; rdfs:subPropertyOf herbkg:associateGene ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:Gene ; rdfs:label "modulates"@en, "调节"@zh ; rdfs:comment "Indicates that a compound modulates gene activity without specifying direction. Specialization of associateGene."@en . herbkg:inhibits a owl:ObjectProperty ; rdfs:subPropertyOf herbkg:modulates ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:Gene ; rdfs:label "inhibits"@en, "抑制"@zh ; rdfs:comment "Indicates that a compound inhibits a gene or its protein product. Specialization of modulates."@en . herbkg:activates a owl:ObjectProperty ; rdfs:subPropertyOf herbkg:modulates ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:Gene ; rdfs:label "activates"@en, "激活"@zh ; rdfs:comment "Indicates that a compound activates a gene or its protein product. Specialization of modulates."@en . herbkg:influenceDisease a owl:ObjectProperty ; rdfs:domain herbkg:Gene ; rdfs:range herbkg:MMDisease ; rdfs:label "influence disease"@en, "影响西医疾病"@zh ; rdfs:comment "Describes the influence of a gene on a modern medicine disease."@en . herbkg:actOn a owl:ObjectProperty ; rdfs:domain herbkg:Compound ; rdfs:range herbkg:MMDisease ; rdfs:label "act on"@en, "作用于西医疾病"@zh ; rdfs:comment "Indicates that a compound acts on a modern medicine disease."@en . ################################################################# # Object Properties — classification ################################################################# herbkg:hasHerbType a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:HerbType ; rdfs:label "has herb type"@en, "具有草药类别"@zh ; rdfs:comment "Classifies a herb."@en . herbkg:hasFormulaType a owl:ObjectProperty ; rdfs:domain herbkg:Formula ; rdfs:range herbkg:FormulaType ; rdfs:label "has formula type"@en, "具有方剂类别"@zh ; rdfs:comment "Classifies a formula."@en . herbkg:hasFunctionType a owl:ObjectProperty ; rdfs:domain herbkg:Function ; rdfs:range herbkg:FunctionType ; rdfs:label "has function type"@en, "具有功效类别"@zh ; rdfs:comment "Classifies a therapeutic function."@en . herbkg:hasSymptomType a owl:ObjectProperty ; rdfs:domain herbkg:Symptom ; rdfs:range herbkg:SymptomType ; rdfs:label "has symptom type"@en, "具有证候类别"@zh ; rdfs:comment "Classifies a TCM syndromic pattern."@en . herbkg:hasSignType a owl:ObjectProperty ; rdfs:domain herbkg:Sign ; rdfs:range herbkg:SignType ; rdfs:label "has sign type"@en, "具有症状类别"@zh ; rdfs:comment "Classifies a clinical sign."@en . herbkg:hasDiseaseType a owl:ObjectProperty ; rdfs:domain herbkg:Disease ; rdfs:range herbkg:DiseaseType ; rdfs:label "has disease type"@en, "具有疾病类别"@zh ; rdfs:comment "Classifies a disease entity."@en . herbkg:hasFlavor a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Flavor ; rdfs:label "has flavor"@en, "具有味"@zh ; rdfs:comment "Assigns an organoleptic flavor category to a herb."@en . herbkg:hasNature a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Nature ; rdfs:label "has nature"@en, "具有药性"@zh ; rdfs:comment "Assigns a TCM nature category to a herb."@en . herbkg:hasChannelTropism a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:ChannelTropism ; rdfs:label "has channel tropism"@en, "具有归经"@zh ; rdfs:comment "Assigns a meridian/channel tropism category to a herb."@en . herbkg:hasToxicity a owl:ObjectProperty ; rdfs:domain herbkg:Herb ; rdfs:range herbkg:Toxicity ; rdfs:label "has toxicity"@en, "具有毒性"@zh ; rdfs:comment "Assigns a toxicity category to a herb."@en . ################################################################# # Object Properties — terminology alignment # # Cross-lingual and cross-branch mappings between entities are expressed # with skos:exactMatch and skos:broadMatch (declared below as annotation # properties). mappedToICD links a disease entity to an ICD-10 code entity. ################################################################# herbkg:mappedToICD a owl:ObjectProperty ; rdfs:domain herbkg:Disease ; rdfs:range herbkg:ICDCode ; rdfs:label "mapped to ICD"@en, "映射至ICD编码"@zh ; rdfs:comment "Maps a disease entity to an ICD-10 code entity used as a normalization anchor."@en . ################################################################# # Object Properties — evidence and provenance on reified associations ################################################################# herbkg:supportedBy a owl:ObjectProperty ; rdfs:domain herbkg:HerbDiseaseAssociation ; rdfs:range herbkg:Evidence ; rdfs:label "supported by"@en, "证据支持"@zh ; rdfs:comment "Links a derived herb–disease association to a supporting evidence record."@en . herbkg:evidenceLevel a owl:ObjectProperty ; rdfs:domain herbkg:HerbDiseaseAssociation ; rdfs:range herbkg:EvidenceLevel ; rdfs:label "evidence level"@en, "证据等级"@zh ; rdfs:comment "Assigns a qualitative confidence level to a derived herb–disease association."@en . herbkg:derivedFrom a owl:ObjectProperty ; rdfs:subPropertyOf prov:wasDerivedFrom ; rdfs:domain herbkg:HerbDiseaseAssociation ; rdfs:range herbkg:SourceDocument ; rdfs:label "derived from"@en, "来源于文献"@zh ; rdfs:comment "Indicates the document-level source from which a derived association was obtained."@en . herbkg:retrievedFrom a owl:ObjectProperty ; rdfs:domain herbkg:HerbDiseaseAssociation ; rdfs:range herbkg:Dataset ; rdfs:label "retrieved from"@en, "检索自数据集"@zh ; rdfs:comment "Indicates the dataset from which a derived association was retrieved."@en . ################################################################# # Released-subset serialization vocabulary # # The released derived subset serializes every statement twice: once as a # direct triple between entities, and once as a reified DerivedAssertion # record carrying the source identifier and source category. The terms below # describe that serialization. They are distinct from the association-level # evidence vocabulary above, which models the evidence attached to a derived # herb-disease association rather than the provenance of an individual # released statement. ################################################################# herbkg:DerivedAssertion a owl:Class ; rdfs:label "Derived assertion"@en, "派生断言"@zh ; rdfs:comment "A reified record of a single statement in the released derived subset, carrying the source identifier and source category from which the statement was obtained."@en . herbkg:assertedSubject a owl:ObjectProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:label "asserted subject"@en, "断言主语"@zh ; rdfs:comment "The subject of the reified statement."@en . herbkg:assertedPredicate a owl:ObjectProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:label "asserted predicate"@en, "断言谓语"@zh ; rdfs:comment "The predicate of the reified statement."@en . herbkg:assertedObject a owl:ObjectProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:label "asserted object"@en, "断言宾语"@zh ; rdfs:comment "The object of the reified statement."@en . herbkg:sourceId a owl:DatatypeProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:range xsd:string ; rdfs:label "source identifier"@en, "来源标识"@zh ; rdfs:comment "A subset-level provenance identifier for the originating record, source entry, or curated evidence unit."@en . herbkg:sourceType a owl:DatatypeProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:range xsd:string ; rdfs:label "source type"@en, "来源类别"@zh ; rdfs:comment "A high-level category describing the origin of the statement, such as cn_abstract, en_abstract, standard_file, or inference."@en . herbkg:mappingType a owl:DatatypeProperty ; rdfs:domain herbkg:DerivedAssertion ; rdfs:range xsd:string ; rdfs:label "mapping type"@en, "映射类别"@zh ; rdfs:comment "A relation-interpretation label used when the statement represents a cross-lingual, cross-branch, or inference-level relation."@en . ################################################################# # Annotation Properties (alignment + provenance) ################################################################# skos:prefLabel a owl:AnnotationProperty . skos:altLabel a owl:AnnotationProperty . skos:exactMatch a owl:AnnotationProperty . skos:broadMatch a owl:AnnotationProperty . dcterms:language a owl:AnnotationProperty . dcterms:source a owl:AnnotationProperty . prov:wasDerivedFrom a owl:AnnotationProperty . ################################################################# # Datatype Properties (minimal, reviewer-safe IDs) ################################################################# herbkg:icd10Code a owl:DatatypeProperty ; rdfs:domain herbkg:MMDisease ; rdfs:range xsd:string ; rdfs:label "ICD-10 code"@en, "ICD-10编码"@zh . herbkg:omimID a owl:DatatypeProperty ; rdfs:domain [ a owl:Class ; owl:unionOf ( herbkg:MMDisease herbkg:Gene ) ] ; rdfs:range xsd:string ; rdfs:label "OMIM ID"@en, "OMIM_ID"@zh . herbkg:casID a owl:DatatypeProperty ; rdfs:domain herbkg:Compound ; rdfs:range xsd:string ; rdfs:label "CAS Registry Number"@en, "CAS号"@zh . herbkg:hasConfidenceScore a owl:DatatypeProperty ; rdfs:domain herbkg:HerbDiseaseAssociation ; rdfs:range xsd:decimal ; rdfs:label "confidence score"@en, "置信度分值"@zh ; rdfs:comment "Assigns a quantitative confidence score to a derived herb–disease association."@en . herbkg:hasLanguage a owl:DatatypeProperty ; rdfs:range xsd:language ; rdfs:label "language tag"@en, "语言标签"@zh ; rdfs:comment "Specifies the language of an entity label. Complements the dcterms:language annotation property."@en . ################################################################# # Notes ################################################################# # This schema contains schema-level definitions only (TBox). It does not # include instance-level data (ABox). # # Cross-paradigm therapeutic links between herbs or formulas and diseases # (herbkg:treatDisease, herbkg:associatedWith) are declared here with domain and range # constraints so that derived assertions can be type-checked, but no # instance of these properties is asserted in this file. Such instances are # produced downstream by ontology-guided path traversal over the # herb–compound–gene–disease chain and its TCM-branch counterpart, and are # reified as herbkg:HerbDiseaseAssociation individuals carrying evidence, # evidence level, confidence, and provenance annotations.