@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix owl2: <http://www.w3.org/2006/12/owl2#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix chear: <http://hadatac.org/ont/chear#> .
@prefix dct:   <http://purl.org/dc/terms/> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix sio:   <http://semanticscience.org/resource/> .
@prefix sco: <https://idea.tw.rpi.edu/projects/heals/studycohort/> .
@prefix cmo: <http://purl.org/twc/ontologies/cmo.owl/#> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix chebi: <http://purl.obolibrary.org/obo/CHEBI_> .
@prefix sco-i: 
<https://idea.tw.rpi.edu/projects/heals/studycohort_individuals/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix sm:   
<http://www.omg.org/techprocess/ab/SpecificationMetadata/> .

sco-i:MetforminStudyArm
	a  owl:Class, sco:InterventionArm; 
	rdfs:subClassOf sio:StudySubject;
	rdfs:label 
	"set of study subjects belonging to the	Metformin intervention arm" ;
	sio:isParticipantIn    sco-i:VitaminB12DeficiencyStudy;
	sio:hasProperty  
	[ a chebi:6801;
	  sio:hasAttribute
	  [ a sco:YearOfFollowUp; sio:hasValue 1; sio:hasUnit sio:Year]
	];    
	sio:hasAttribute 
	[ a sco:PopulationSize; sio:hasValue 859],
	[ a sio:Age; sio:hasUnit sio:Year;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 56.7],
	  [a sio:StandardDeviation; sio:hasValue 10.2]           
	],        
	[ a cmo:0000105;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 33.2], 
	  [a sio:StandardDeviation; sio:hasValue 6.9]
	],
	[ a ncit:C64796;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 40.6], 
	  [a sio:StandardDeviation; sio:hasValue 3.7]
	],
    [ 
      a ncit:C64333; 
      sio:hasUnit sco:PicogramPerMillimeter;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 546],
	  [a sio:StandardDeviation; sio:hasValue 337.2]
	],
	[ 
	  a ncit:C64849;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 5.9], 
	  [a sio:StandardDeviation; sio:hasValue 0.64]
	],
	[ 
	  a chebi:17230;
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 10.8], 
	  [a sio:StandardDeviation; sio:hasValue 3.6]
	],
	[ 
	  a chebi:35143; 
	  sio:hasUnit sco:GramPerDeciliter; 
	  sio:hasAttribute 
	  [ a sio:Mean; sio:hasValue 13.6], 
	  [a sio:StandardDeviation; sio:hasValue 1.3]
	] .

sco-i:MaleMetforminStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:label       "Male Study Subject" ;
	rdfs:subClassOf 
	[ 
	    a owl:Restriction;
	    owl:onProperty sio:hasAttribute;
	    owl:someValuesFrom sio:Male
	];
	sio:hasAttribute 
	[ a sco:PopulationSize; sio:hasValue 285 ], 
	[ 
	    a sio:Percentage; 
	    sio:hasValue 33.2; 
	    sio:inRelationTo sco-i:MetforminStudyArm
	] .

sco-i:FemaleMetforminStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:label       "Female Study Subjects" ;
	rdfs:subClassOf 
	[ 
	    a owl:Restriction;
	    owl:onProperty sio:hasAttribute; 
	    owl:someValuesFrom sio:Female
	];
	sio:hasAttribute 
	[ a sco:PopulationSize; sio:hasValue 574 ], 
	[ 
	    a sio:Percentage;
	    sio:hasValue 66.8;
	    sio:inRelationTo sco-i:MetforminStudyArm
	] .

sco-i:WhiteMetforminStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:subClassOf 
	[ 
	    a owl:Restriction;
	    owl:onProperty sio:hasAttribute; 
	    owl:someValuesFrom chear:White
	];
	sio:hasAttribute  
	[ 
	    a sio:Percentage;
	    sio:hasValue 56.2;
	    sio:inRelationTo sco-i:MetforminStudyArm
	 ] .

sco-i:AnemiaStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:subClassOf 
	[
    	a owl:Restriction;
    	owl:onProperty sio:hasAttribute;
    	owl:someValuesFrom ncit:C2869
	];
	sio:hasAttribute  
	[ 
	    a sio:Percentage;
	    sio:hasValue 14.2; 
	    sio:inRelationTo sco-i:MetforminStudyArm
	 ] .

sco-i:DiabetesStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:subClassOf 
	[ 
    	a owl:Restriction; 
    	owl:onProperty sio:hasAttribute; 
    	owl:someValuesFrom sco:Diabetes
    ];
	sio:hasAttribute  
	[ 
	    a sio:Percentage;
	    sio:hasValue 33.2; 
	    sio:inRelationTo sco-i:MetforminStudyArm
	] .


sco-i:NonWhiteMetforminStudySubject a owl:Class;
	rdfs:subClassOf sco-i:MetforminStudyArm;
	rdfs:label       "Non White Metformin Study Subject" ;
	rdfs:subClassOf 
	[
	    a owl:Restriction;
	    owl:onProperty sio:hasAttribute;
	    owl:someValuesFrom chear:UnknownRace
	];
	sio:hasAttribute  
	[ 
	    a sio:Percentage; 
	    sio:hasValue 43.2; 
	    sio:inRelationTo sco-i:MetforminStudyArm
	 ] .

sco-i:VitaminB12DeficiencyStudy
	a  owl:NamedIndividual , sco:ClinicalTrial ;
	rdfs:label "study of vitamin B12 deficiency in metformin" ;
	rdfs:seeAlso   
	"https://clinicaltrials.gov/ct2/show/NCT00038727" ;
	dct:abstract    "Vitamin B12 deficiency may occur with metformin treatment, but few studies have assessed risk with long-term use" ;
	dct:creator     "Edelstein, S.L.","Temprosa, M.G." , 
	"White, N.H." , "Bray, G.A." , "Aroda, V.R." , 
	"Crandall, J.P." , "Orchard, T.J." , "Knowler, W.C." ,
	"David, S.S." , "Marcovina, S.M." , "Goldberg, R.B." ;
	dct:title       "Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study" ;
	sm:documentURL  
	"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880159/" ;
	sio:hasParticipant   sco-i:MetforminStudyArm .