<?xml version="1.0"?>
<rdf:RDF xmlns="https://purl.org/heals/sco/"
xml:base="https://purl.org/heals/sco/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:uo="http://purl.obolibrary.org/obo/UO_"
xmlns:dct="http://purl.org/dc/terms/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:sco="https://purl.org/heals/sco/"
xmlns:sio="http://semanticscience.org/resource/"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:doid="http://purl.obolibrary.org/obo/DOID_"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:ncit="http://purl.obolibrary.org/obo/NCIT_"
xmlns:pato="http://purl.obolibrary.org/obo/PATO_"
xmlns:prov="http://www.w3.org/ns/prov#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:skos="http://www.w3.org/2004/02/skos/core#"
xmlns:vann="http://purl.org/vocab/vann/"
xmlns:chear="http://hadatac.org/ont/chear#"
xmlns:hasco="http://hadatac.org/ont/hasco#"
xmlns:stato="http://purl.obolibrary.org/obo/STATO_"
xmlns:hasco1="http://hadatac.org/ont/hasco/"
xmlns:schema="http://schema.org/"
xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:provcare="http://www.case.edu/ProvCaRe/provcare#"
xmlns:fibo-fnd-utl-av="http://www.omg.org/spec/EDMC-FIBO/FND/Utilities/AnnotationVocabulary/">
<owl:Ontology rdf:about="https://purl.org/heals/sco/">
<owl:versionIRI rdf:resource="https://purl.org/heals/sco/1.1.0"/>
<owl:imports rdf:resource="https://purl.org/heals/chearexternal.ttl"/>
<dct:abstract rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Study Cohort Ontology (SCO) is developed to model overall structure and patterns of cohort variables and control/intervention groups defined within the structured population descriptions (commonly referred to as Table1's or Cohort Summary Tables)of observational case studies and clinical trials. We maintain only domain agnostic and commonly occuring subject variables and interventions in SCO, and we have a suite of ontologies (Diseases, Medications, LabResults etc) to encode Diabetes related terminology. We have adopted a bottom-up approach to modeling and we have revised the structure of SCO upon investigation of a few research studies (11 to be precise) from the Pharmacological Interventions (Chapter 8) and Cardiovascular Complications (Chapter 9) of the American Diabetes Association (ADA)’s Standards of Medical Care 2018 CPG. We enable deep drive visualizations driven off queries to knowledge graphs modeled on SCO, to help assist physician visualize the similarity of a patient to a study group, at a quick glance. We welcome contributions and suggestions to extend SCO to represent cohort descriptions of publications targeted to other diseases, and we plan to release set of tools to make this process seamless.</dct:abstract>
<dct:contributor>Deborah L. McGuinness</dct:contributor>
<dct:contributor>James P. McCusker</dct:contributor>
<dct:contributor>Oshani Seneviratne</dct:contributor>
<dct:creator>Shruthi Chari</dct:creator>
<dct:description>The Study Cohort Ontology encodes the vocabulary to represent population desriptions in research studies, and provides the ability to model the aggregative descriptive statistical measures defined on the variables of subjects who are participants in the study population. We make it possible to represent a study component considered for determining the patient alignment to a research study, and we assist physicians in evaluating the fit of their patient population to the study population. In SCO, we are building a world-view inspired by the upper level Ontology SemanticScience Integrated Ontology (SIO) to model the descriptive statistics of characteristics on a set of patients (patient group) administered a medical intervention, and studied for an outcome in a research study. Since we capture the various definitions of patient groups (ie. by interventional measures or by control mechanisms), we provide the basic framework for filtering searches and to define cohort similarity at different granularities. ( cohort level and the study group levels ). For researchers who wish to contribute to the expansion of our ontology, we advise that they refer to our ontology documentation to familiarize themselves with the structure and term annotations ( such as definitions and labels).</dct:description>
<dct:title>Semantic Modeling of Cohort Descriptions in Research Studies</dct:title>
<rdfs:label>Study Cohort Ontology</rdfs:label>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/IAO_0000112 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000112"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000114 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000114"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000116 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000116"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000117 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000119 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000412 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000589 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000589"/>
<!-- http://purl.obolibrary.org/obo/NCIT_NHC0 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_NHC0"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P106 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P106"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P108 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P108"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P207 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P207"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P208 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P208"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P322 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P322"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P325 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P325"/>
<!-- http://purl.obolibrary.org/obo/NCIT_P366 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/NCIT_P366"/>
<!-- http://purl.obolibrary.org/obo/STATO_0000032 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/STATO_0000032"/>
<!-- http://purl.org/dc/elements/1.1/date -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date"/>
<!-- http://purl.org/dc/terms/abstract -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/abstract"/>
<!-- http://purl.org/dc/terms/source -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/source"/>
<!-- http://www.geneontology.org/formats/oboInOwl#created_by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasAlternativeId -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
<!-- http://www.geneontology.org/formats/oboInOwl#id -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
<!-- http://www.geneontology.org/formats/oboInOwl#inSubset -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
<!-- http://www.omg.org/spec/EDMC-FIBO/FND/Utilities/AnnotationVocabulary/adaptedFrom -->
<owl:AnnotationProperty rdf:about="http://www.omg.org/spec/EDMC-FIBO/FND/Utilities/AnnotationVocabulary/adaptedFrom"/>
<!-- http://www.w3.org/2000/01/rdf-schema#synonym -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#synonym"/>
<!-- http://www.w3.org/ns/prov#wasAttributedTo -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/ns/prov#wasAttributedTo"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://semanticscience.org/resource/hasParticipant -->
<owl:ObjectProperty rdf:about="http://semanticscience.org/resource/hasParticipant"/>
<!-- http://semanticscience.org/resource/hasProperty -->
<owl:ObjectProperty rdf:about="http://semanticscience.org/resource/hasProperty"/>
<!-- http://semanticscience.org/resource/hasUnit -->
<owl:ObjectProperty rdf:about="http://semanticscience.org/resource/hasUnit"/>
<!-- http://www.w3.org/2000/01/rdf-schema#subClassOf -->
<owl:ObjectProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#subClassOf"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://hadatac.org/ont/chear#Anthropometry -->
<owl:Class rdf:about="http://hadatac.org/ont/chear#Anthropometry">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/SubjectCharacteristic"/>
</owl:Class>
<!-- http://hadatac.org/ont/chear#Demographic -->
<owl:Class rdf:about="http://hadatac.org/ont/chear#Demographic">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/SubjectCharacteristic"/>
<dct:source>Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition</dct:source>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the science dealing with populations, including matters of health, disease, births, and mortality</skos:definition>
</owl:Class>
<!-- http://hadatac.org/ont/chear#MedicalTherapy -->
<owl:Class rdf:about="http://hadatac.org/ont/chear#MedicalTherapy">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
<dct:source>https://en.wikipedia.org/wiki/Therapy</dct:source>
<rdfs:label>medical therapy</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the attempted remediation of a health problem, usually following a diagnosis</skos:definition>
</owl:Class>
<!-- http://hadatac.org/ont/chear#UnderweightOrNormal -->
<rdf:Description rdf:about="http://hadatac.org/ont/chear#UnderweightOrNormal">
<oboInOwl:hasExactSynonym>Normal or Underweight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Underweight or Normal</oboInOwl:hasExactSynonym>
</rdf:Description>
<!-- http://hadatac.org/ont/hasco#ResearchStudy -->
<owl:Class rdf:about="http://hadatac.org/ont/hasco#ResearchStudy">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/Study"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/CohortDescription"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasParticipant"/>
<owl:someValuesFrom rdf:resource="http://semanticscience.org/resource/StudySubject"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CARO_0000000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0030000"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">anatomical entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CARO_0000003 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000003">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000006"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/caro.owl"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label xml:lang="en">anatomical structure</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">connected anatomical structure</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CARO_0000006 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000006">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000000"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/caro.owl"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label xml:lang="en">material anatomical entity</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material anatomical entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CARO_0010000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0010000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/caro.owl"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multicellular anatomical structure</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CARO_0030000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0030000">
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CL_0000000 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label xml:lang="en">cell</rdfs:label>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/DOID_4 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/DOID_4">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/BiologicalQuality"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/doid.owl"/>
<dct:source>http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf</dct:source>
<rdfs:label>disease or condition</rdfs:label>
<skos:definition>A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism</skos:definition>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0001513 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0001513">
<obo:IAO_0000115>Accumulation of substantial excess body fat.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D009765</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:414915002</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:414916001</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0028754</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>Having too much body fat</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0001513</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0001956 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0001956">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001513"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obesity located preferentially in the trunk of the body as opposed to the extremities.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0008885</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D056128</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:248311001</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0311277</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Centripetal obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Truncal obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0001956</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Truncal obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0004324 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0004324">
<obo:IAO_0000115>Abnormally increased body weight.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peter</oboInOwl:created_by>
<oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008-02-27T03:21:00Z</oboInOwl:creation_date>
<oboInOwl:hasAlternativeId>HP:0045083</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D015430</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:161831008</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:262286000</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:8943002</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0043094</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased body weight</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weight gain</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0004324</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased body weight</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0004325 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0004325">
<rdfs:subClassOf rdf:resource="http://hadatac.org/ont/chear#UnderweightOrNormal"/>
<obo:IAO_0000115>Abnormally low body weight.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peter</oboInOwl:created_by>
<oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008-02-27T03:22:00Z</oboInOwl:creation_date>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0001823</oboInOwl:hasAlternativeId>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0001826</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D013851</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D015431</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:161832001</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:248342006</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:262285001</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:89362005</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0041667</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C1262477</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C1844806</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Decreased body weight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Decreased weight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Low body weight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Low weight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Underweight</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weight less than 3rd percentile</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0004325</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Decreased body weight</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0008915 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0008915">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001956"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Truncal obesity with onset during childhood, defined as between 2 and 10 years of age.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0008874</oboInOwl:hasAlternativeId>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C1859846</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Truncal obesity apparent in childhood</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0008915</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Childhood-onset truncal obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0012743 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0012743">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001513"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Excessive fat around the stomach and abdomen.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peter</oboInOwl:created_by>
<oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014-03-23T05:00:05Z</oboInOwl:creation_date>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSH:D056128</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SNOMEDCT_US:248311001</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UMLS:C0311277</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abdominal obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Central obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human_phenotype</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HP:0012743</oboInOwl:id>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Abdominal obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0025499 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0025499">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001513"/>
<obo:IAO_0000115>Obesity with a body mass index of 30 to 34.9 kg per square meter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HPO:probinson</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-14T20:06:40Z</dc:date>
<oboInOwl:hasExactSynonym>Class 1 obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Obesity grade 1</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">Class I obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0025500 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0025500">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001513"/>
<obo:IAO_0000115>Obesity with a body mass index of 35 to 39.9 kg per square meter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HPO:probinson</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-14T20:08:43Z</dc:date>
<oboInOwl:hasExactSynonym>Class 2 obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Obesity grade 2</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">Class II obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0025501 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0025501">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0001513"/>
<obo:IAO_0000115>Obesity with a body mass index of 40 kg per square meter or higher.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HPO:probinson</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-14T20:09:17Z</dc:date>
<oboInOwl:hasExactSynonym>Class 3 obesity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Obesity grade 3</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">Class III obesity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0025502 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0025502">
<obo:IAO_0000115>Increased body weight with a body mass index of 25-29.9 kg per square meter.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HPO:probinson</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-14T20:12:36Z</dc:date>
<rdfs:label xml:lang="en">Overweight</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/HP_0045082 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/HP_0045082">
<obo:IAO_0000115>Abnormally decreased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of underweight compared to averages.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<oboInOwl:hasExactSynonym>Decreased BMI</oboInOwl:hasExactSynonym>
<rdfs:label>Decreased body mass index</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142488 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142488">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C61256"/>
<obo:IAO_0000115>Review of clinical information to determine veracity, thoroughness, and dependability.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142488</obo:NCIT_NHC0>
<obo:NCIT_P106>Activity</obo:NCIT_P106>
<obo:NCIT_P108>Data Monitoring</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>Process by which clinical data are examined for completeness, consistency, and accuracy.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Data Monitoring</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>data monitoring</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>data monitoring</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142526 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142526">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A clinical trial in which computerized systems are used to plan, collect, access, exchange, and archive data.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142526</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Electronic Clinical Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>Clinical trial in which primarily electronic processes are used to plan, collect (acquire), access, exchange, and archive data required for conduct, management, analysis, and reporting of the trial. NOTE: FDA has recently drawn a distinction between studies and trials. Both words refer to systematic efforts to obtain evidence relevant to regulatory authorities, but, depending on regulatory context and particularly in the case of postmarketing commitments, a study might not be the appropriate word for a clinical trial (prospective, controlled, randomized), but should be reserved instead for surveillance, structured gathering of information, epidemiological studies, or even animal studies [DRAFT Guidance for industry Postmarketing studies and Clinical Trials-implementation of section 505(o) of the Federal Food, Drug, and Cosmetic act]. Synonyms: eClinical study, eClinical investigation.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Electronic Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>eClinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>eclinical trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>electronic clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142539 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142539">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A clinical trial with the objective of demonstrating clinical insignificance between the responses to two or more treatments.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142539</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Equivalence Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A trial with the primary objective of showing that the response to two or more treatments differs by an amount that is clinically unimportant. NOTE: This is usually demonstrated by showing that the true treatment difference is likely to lie between a lower and an upper equivalence margin of clinically acceptable differences.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Equivalence Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>equivalence trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>equivalence trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142547 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142547">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A type of clinical trial that involves low dosage and short duration of drug exposure for a limited number of study participants with the intent of gathering preliminary data on the mechanism of action, pharmacodynamics, pharmacokinetics, or bioavailability of promising therapeutic candidate agents in human subjects.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142547</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Exploratory Investigational New Drug Study</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A clinical study that is conducted early in Phase 1; involves very limited human exposure and has no therapeutic or diagnostic intent (e.g., screening studies, microdose studies) [FDA Guidance for industry, investigators, and Reviewers: exploratory IND studies, January 2006] See also Phase 0.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Exploratory IND Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Exploratory Investigational New Drug Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>exploratory IND study</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>exploratory investigational new drug study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142601 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142601">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A clinical trial that is non-interventional by design but includes diagnostic or monitoring procedures that carry minimal risk or impact on patients.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142601</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Low-interventional Clinical Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A clinical trial which fulfills all of the following conditions: (a) the investigational medicinal products, excluding placebos, are authorized; (b) according to the protocol of the clinical trial, (i) the investigational medicinal products are used in accordance with the terms of the marketing authorization; or (ii) the use of the investigational medicinal products is evidence-based and supported by published scientific evidence on the safety and efficacy of those investigational medicinal products in any of the Member States concerned; and (c) the additional diagnostic or monitoring procedures do not pose more than minimal additional risk or burden to the safety of the subjects compared to normal clinical practice in any Member State concerned. [REGULATION (EU) No 536/2014 Article 2.2.(3)]</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Low-interventional Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>low-interventional clinical trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>low-interventional clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142603 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142603">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A type of clinical trial in which the therapeutic benefits of a marketed product are either clarified or preferentially compared to another marketed product.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142603</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Marketing Support Trials</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>Clinical studies that are designed to clarify therapeutic benefits of a marketed product or to show potential decision-makers the rationale for preferring one therapy over another.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Marketing Support Trials</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>marketing support trials</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>marketing support trials</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142609 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142609">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A type of clinical trial in which 10,000 or more subjects are enrolled.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142609</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Mega-Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>Massive trials that test the advantages of therapeutic interventions by enrolling 10,000 or more subjects.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Mega-Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>large sample trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>mega-trials</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>mega-trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142641 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142641">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A study designed to test the effectiveness of an intervention in a broad routine clinical practice.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142641</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Pragmatic Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>Term used to describe a clinical study designed to examine the benefits of a product under real world conditions.</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Pragmatic Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>pragmatic trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>pragmatic trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C142722 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C142722">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A trial with the primary objective of showing that the response to the investigational product is superior to a comparative agent (active or placebo control). (ICH)</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C142722</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Superiority Trial</obo:NCIT_P108>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A trial with the primary objective of showing that the response to the investigational product is superior to a comparative agent (active or placebo control). [ICH E9]</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Superiority Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>superiority trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>superiority trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15206 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15206">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C63536"/>
<obo:IAO_0000115>Research conducted with human subjects or on material of human origin in which an investigator directly interacts with human subjects; includes development of new technologies, study of mechanisms of human diseases, therapy, clinical trials, epidemiologic, behavior, and health services research.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15206</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Clinical Study</obo:NCIT_P108>
<obo:NCIT_P207>C0008972</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P322>FDA</obo:NCIT_P322>
<obo:NCIT_P325>A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. [ClinicalTrials.gov] See also clinical trial.</obo:NCIT_P325>
<obo:NCIT_P325>A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. [ClinicalTrials.gov] See also clinical trial. (CDISC Glossary)</obo:NCIT_P325>
<obo:NCIT_P366>Clinical_Study</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>CLINICAL STUDY</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Research</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Studies</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>clinical study</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132298"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132310"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C54447"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C54587"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>clinical study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15362 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15362">
<rdfs:subClassOf rdf:resource="http://hadatac.org/ont/hasco#ResearchStudy"/>
<obo:IAO_0000115>An uncontrolled observational study containing a detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15362</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Case Study</obo:NCIT_P108>
<obo:NCIT_P207>C0085973</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P325>A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).</obo:NCIT_P325>
<obo:NCIT_P325>A study in which the subject with the condition under study (the case) is compared against a theoretical/historical model of distribution that serves as a control.</obo:NCIT_P325>
<obo:NCIT_P366>Case_Study</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>CASE ONLY</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Case Report</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Case Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>case report</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C127259"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132298"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66830"/>
<rdfs:label>case study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15429 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15429">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16203"/>
<obo:IAO_0000115>Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15429</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Research Activity</obo:NCIT_P108>
<obo:NCIT_P207>C0242481</obo:NCIT_P207>
<obo:NCIT_P325>A scientific study of nature that sometimes includes processes involved in health and disease. For example, clinical trials are research studies that involve people. These studies may be related to new ways to screen, prevent, diagnose, and treat disease. They may also study certain outcomes and certain groups of people by looking at data collected in the past or future.</obo:NCIT_P325>
<obo:NCIT_P366>Research_Activity</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Research</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Research Activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>research study</oboInOwl:hasExactSynonym>
<rdfs:label>research activity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15602 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15602">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C70820"/>
<obo:IAO_0000115>A clinical research protocol designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15602</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Phase III Trial</obo:NCIT_P108>
<obo:NCIT_P207>C0282461</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A study to compare the results of people taking a new treatment with the results of people taking the standard treatment (for example, which group has better survival rates or fewer side effects). In most cases, studies move into phase III only after a treatment seems to work in phases I and II. Phase III trials may include hundreds of people.</obo:NCIT_P325>
<obo:NCIT_P325>Phase 3. Studies are expanded controlled and uncontrolled trials. They are performed after preliminary evidence suggesting effectiveness of the drug has been obtained, and are intended to gather the additional information about effectiveness and safety that is needed to confirm efficacy and evaluate the overall benefit-risk relationship of the drug and to provide an adequate basis for physician labeling. NOTE: Phase 3 studies usually include from several hundred to several thousand subjects. [After FDA CDER Handbook, ICH E8] (CDISC glossary)</obo:NCIT_P325>
<obo:NCIT_P325>Studies are expanded controlled and uncontrolled trials. They are performed after preliminary evidence suggesting effectiveness of the drug has been obtained and are intended to gather the additional information about effectiveness and safety that is needed to confirm efficacy and evaluate the overall benefit-risk relationship of the drug and to provide an adequate basis for physician labeling. NOTE: Phase 3 studies usually include from several hundred to several thousand subjects. [after FDA CDER handbook, ICH E8]</obo:NCIT_P325>
<obo:NCIT_P366>Phase_III_Trial</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>3</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Trials, Phase III</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>PHASE III TRIAL</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase 3 Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase III Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase III Protocol</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase III Study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase III Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase III Trials</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Trial Phase 3</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>phase 3</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>phase III trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132298"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66737"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66830"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>phase III trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15693 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15693">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C70820"/>
<obo:IAO_0000115>A clinical research protocol designed to study the safety, dosage levels and response to new treatment. Phase I/II trials combine a Phase I and a Phase II trial of the same treatment into a single protocol.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15693</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Phase I/II Trial</obo:NCIT_P108>
<obo:NCIT_P207>C1519043</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P325>A class of clinical study that combines elements characteristic of traditional Phase I and Phase II trials. See also Phase I, Phase II.</obo:NCIT_P325>
<obo:NCIT_P325>A trial to study the safety, dosage levels, and response to a new treatment.</obo:NCIT_P325>
<obo:NCIT_P366>Phase_I_II_Trial</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>1-2</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>PHASE I/II TRIAL</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase I/II Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Phase I/II trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Trial Phase 1-2</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Trial Phase 1/2</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132298"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66737"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66830"/>
<rdfs:label>phase I/II trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15835 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15835">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15693"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15864"/>
<obo:IAO_0000115>Select candidate vaccines or concepts suitable for Phase I and Phase II trials and conduct these trials.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15835</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Phase I and II Vaccine Trials</obo:NCIT_P108>
<obo:NCIT_P207>C1519044</obo:NCIT_P207>
<obo:NCIT_P366>Phase_I_and_II_Vaccine_Trials</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Phase I and II Vaccine Trials</oboInOwl:hasExactSynonym>
<rdfs:label>phase I and II Vaccine trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15864 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15864">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15864</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Vaccine Clinical Trial</obo:NCIT_P108>
<obo:NCIT_P207>C1519888</obo:NCIT_P207>
<obo:NCIT_P366>Vaccine_Clinical_Trial</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Vaccine Clinical Trial</oboInOwl:hasExactSynonym>
<rdfs:label>vaccine clinical trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C15873 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C15873">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15602"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15864"/>
<obo:IAO_0000115>Select suitable vaccine candidates and support efficacy trials when appropriate criteria are met.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C15873</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Phase III Large Scale Vaccine Trial</obo:NCIT_P108>
<obo:NCIT_P207>C1519902</obo:NCIT_P207>
<obo:NCIT_P366>Vaccine_Trial-Phase_III_Large_Scale</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Phase III Large Scale Vaccine Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Vaccine Trial-Phase III Large Scale</oboInOwl:hasExactSynonym>
<rdfs:label>phase III large scale vaccine trial</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C16104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16104">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C70824"/>
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<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C16104</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Multi-Institutional Clinical Trial</obo:NCIT_P108>
<obo:NCIT_P207>C0206012</obo:NCIT_P207>
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P325>A clinical trial that is carried out at more than one medical institution.</obo:NCIT_P325>
<obo:NCIT_P325>Clinical trial conducted according to a single protocol but at more than one site and, therefore, carried out by more than one investigator. [ICH E9 Glossary] See investigator/ institution.</obo:NCIT_P325>
<obo:NCIT_P366>Multi-Institutional_Clinical_Trial</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Multi-Institutional Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>multicenter study</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>multicenter trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<rdfs:label>multi-institutional clinical trial</rdfs:label>
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<!-- http://purl.obolibrary.org/obo/NCIT_C16123 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16123">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A clinical trial that is not therapeutic, preventive or diagnostic.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C16123</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Clinical Trial, Other</obo:NCIT_P108>
<obo:NCIT_P207>C1516648</obo:NCIT_P207>
<obo:NCIT_P366>Clinical_Trials_Other</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Clinical Trial, Other</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Trials, Other</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Other Clinical Trial</oboInOwl:hasExactSynonym>
<rdfs:label>clinical trial, other</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C16203 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16203">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C43431"/>
<obo:IAO_0000115>Any specific activity undertaken during the course of a clinical study or research protocol.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C16203</obo:NCIT_NHC0>
<obo:NCIT_P106>Activity</obo:NCIT_P106>
<obo:NCIT_P108>Clinical or Research Activity</obo:NCIT_P108>
<obo:NCIT_P207>C1516654</obo:NCIT_P207>
<obo:NCIT_P366>Clinical_or_Research_Activity</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Clinical or Research Activity</oboInOwl:hasExactSynonym>
<rdfs:label>clinical or research activity</rdfs:label>
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<!-- http://purl.obolibrary.org/obo/NCIT_C18237 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C18237">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C41259"/>
<obo:IAO_0000115>Denotes a person having origins in any indigenous people of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment. The concept refers to population subgroups such as Eskimos, Aleuts, Inupiat, Yupik, Alutiiq, Egegik,and Pribilovian, Alaskan Athabascan, Tlingit, and Haida. The concept refers also to individuals who classify themselves as such.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C18237</obo:NCIT_NHC0>
<obo:NCIT_P106>Population Group</obo:NCIT_P106>
<obo:NCIT_P108>Alaska Native</obo:NCIT_P108>
<obo:NCIT_P207>C0682125</obo:NCIT_P207>
<obo:NCIT_P325>The native people of Alaska.</obo:NCIT_P325>
<obo:NCIT_P366>Alaska_Native</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>ALASKA NATIVE</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Alaska Indian</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Alaska Indians</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Alaska Native</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Alaska Natives</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Alaskan Native</oboInOwl:hasExactSynonym>
<rdfs:label>Alaska Native</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C18707 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C18707">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C71104"/>
<obo:IAO_0000115>A clinical trial that uses materials from some other clinical trial.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C18707</obo:NCIT_NHC0>
<obo:NCIT_P106>Governmental or Regulatory Activity</obo:NCIT_P106>
<obo:NCIT_P108>Adjunct Clinical Trial</obo:NCIT_P108>
<obo:NCIT_P207>C1516638</obo:NCIT_P207>
<obo:NCIT_P366>Clinical_Trials_Adjunct</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Adjunct Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Trial, Adjunct</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Clinical Trials, Adjunct</oboInOwl:hasExactSynonym>
<rdfs:label>adjunct clinical trial</rdfs:label>
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<!-- http://purl.obolibrary.org/obo/NCIT_C25613 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25613">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<obo:IAO_0000115>A fraction or ratio with 100 understood as the denominator.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C25613</obo:NCIT_NHC0>
<obo:NCIT_P106>Conceptual Entity</obo:NCIT_P106>
<obo:NCIT_P108>Percentage</obo:NCIT_P108>
<obo:NCIT_P207>C0439165</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P322>NCPDP</obo:NCIT_P322>
<obo:NCIT_P325>One hundred times the quotient of one quantity divided by another, with the same units of measurement.</obo:NCIT_P325>
<obo:NCIT_P366>Percentage</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>%</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Percentage</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66770"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66830"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C71620"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C77526"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C85494"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C89415"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C89509"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C91101"/>
<rdfs:label>percentage</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C41259 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCIT_C41259">
<oboInOwl:hasExactSynonym>AMERICAN INDIAN OR ALASKA NATIVE</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>American Indian or Alaska Native</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>First Nations</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Native American</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Native Americans</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>american indian or alaska native</oboInOwl:hasExactSynonym>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/NCIT_C43431 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C43431">
<rdfs:subClassOf rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
<obo:IAO_0000115>An active process; excludes processes and mechanisms which fulfill biological functions.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C43431</obo:NCIT_NHC0>
<obo:NCIT_P106>Activity</obo:NCIT_P106>
<obo:NCIT_P108>Activity</obo:NCIT_P108>
<obo:NCIT_P207>C0441655</obo:NCIT_P207>
<obo:NCIT_P322>BRIDG</obo:NCIT_P322>
<obo:NCIT_P325>Any action that can, in the context of a study or a post-marketing investigation, be defined, planned, scheduled or performed. EXAMPLE(S): surgical procedure, laboratory test, administration of a drug.</obo:NCIT_P325>
<obo:NCIT_P366>Activity</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Activity</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>General activity</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C105551"/>
<rdfs:label>activity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C43877 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C43877">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C41259"/>
<obo:IAO_0000115>Denotes a person having origins in one of the indigenous peoples of North America, who lived on the continent prior to the European colonization. The term includes individuals belonging to a large number of tribes, states, and ethnic groups, many of them still enduring as communities.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C43877</obo:NCIT_NHC0>
<obo:NCIT_P106>Population Group</obo:NCIT_P106>
<obo:NCIT_P108>American Indian</obo:NCIT_P108>
<obo:NCIT_P207>C0002460</obo:NCIT_P207>
<obo:NCIT_P325>The native people of North America.</obo:NCIT_P325>
<obo:NCIT_P366>American_Indian</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>AMERICAN INDIAN</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>American Indian</oboInOwl:hasExactSynonym>
<rdfs:label>American Indian</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C44256 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C44256">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<obo:IAO_0000115>Quotient of quantities of the same kind for different components within the same system.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C44256</obo:NCIT_NHC0>
<obo:NCIT_P106>Quantitative Concept</obo:NCIT_P106>
<obo:NCIT_P108>Ratio</obo:NCIT_P108>
<obo:NCIT_P207>C0456603</obo:NCIT_P207>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:NCIT_P322>UCUM</obo:NCIT_P322>
<obo:NCIT_P325>The quotient of one quantity divided by another, with the same units of measurement.</obo:NCIT_P325>
<obo:NCIT_P366>Ratio</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>RATIO</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Ratio</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>ratio</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>{RATIO}</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>{Ratio}</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C19752"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66770"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C66830"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67567"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C71620"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C77526"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C85494"/>
<rdfs:label>ratio</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C61256 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C61256">
<obo:IAO_0000115>The act of observing something (and sometimes keeping a record of it).</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C61256</obo:NCIT_NHC0>
<obo:NCIT_P106>Activity</obo:NCIT_P106>
<obo:NCIT_P108>Monitoring</obo:NCIT_P108>
<obo:NCIT_P208>CL415337</obo:NCIT_P208>
<obo:NCIT_P325>In medicine, to regularly watch and check a person or condition to see if there is any change. Also refers to a device that records and/or displays patient data, such as for an electrocardiogram (EKG).</obo:NCIT_P325>
<obo:NCIT_P366>Monitoring</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Monitoring</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>monitor</oboInOwl:hasExactSynonym>
<rdfs:label>monitoring</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C63536 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C63536">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15429"/>
<obo:IAO_0000115>A detailed examination, analysis, or critical inspection of a subject designed to discover facts about it.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C63536</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Study</obo:NCIT_P108>
<obo:NCIT_P207>C0947630</obo:NCIT_P207>
<obo:NCIT_P366>Study</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Study</oboInOwl:hasExactSynonym>
<rdfs:label>study</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C70820 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C70820">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15206"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C70820</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Clinical Study by Phase</obo:NCIT_P108>
<obo:NCIT_P207>C2347801</obo:NCIT_P207>
<obo:NCIT_P366>Clinical_Study_by_Phase</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Clinical Study by Phase</oboInOwl:hasExactSynonym>
<rdfs:label>clinical study by phase</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C70824 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C70824">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15206"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<obo:NCIT_NHC0>C70824</obo:NCIT_NHC0>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P108>Clinical Study by Organizational Parameters</obo:NCIT_P108>
<obo:NCIT_P207>C2347800</obo:NCIT_P207>
<obo:NCIT_P366>Clinical_Study_by_Organizational_Parameters</obo:NCIT_P366>
<oboInOwl:hasExactSynonym>Clinical Study by Organizational Parameters</oboInOwl:hasExactSynonym>
<rdfs:label>clinical study by organizational parameters</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/NCIT_C71104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C71104">
<rdfs:subClassOf rdf:resource="http://hadatac.org/ont/hasco#ResearchStudy"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C15206"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000001">
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<obo:IAO_0000589>quality (PATO)</obo:IAO_0000589>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">quality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000068 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000068">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">qualitative</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000069 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000069">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000068"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">deviation(from_normal)</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000125 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000125">
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000128 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000128">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001035"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">weight</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000460 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000460">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">abnormal</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0000582 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000582">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000128"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002245"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">increased weight</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001018 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001018">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">physical quality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001035 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001035">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">force</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001241 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001241">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">physical object quality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001309 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001309">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/pato.owl"/>
<oboInOwl:hasAlternativeId rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:0000081</oboInOwl:hasAlternativeId>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">period</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">quality</oboInOwl:hasOBONamespace>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">time</oboInOwl:hasRelatedSynonym>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:0001309</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/pato#attribute_slim"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/pato#hpo_slim"/>
<rdfs:label>duration</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001708 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001708">
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0001869 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001869">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000460"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pathological</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0002245 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002245">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001035"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">increased force</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0002300 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002300">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">increased quality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATO_0002305 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002305">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">increased object quality</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/STATO_0000193 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/STATO_0000193">
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000115>is a population whose individual members realize (may be expressed as) a combination of inclusion rule values specifications or resulting from a sampling process (e.g. recruitment followed by randomization to group) on which a number of measurements will be carried out, which may be used as input to statistical tests and statistical inference.</obo:IAO_0000115>
<obo:IAO_0000117 xml:lang="en">Alejandra Gonzalez-Beltran</obo:IAO_0000117>
<obo:IAO_0000117>Orlaith Burke</obo:IAO_0000117>
<obo:IAO_0000117>Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119 xml:lang="en">STATO</obo:IAO_0000119>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/stato.owl"/>
<obo:STATO_0000032 xml:lang="en">statistical sample</obo:STATO_0000032>
<rdfs:label>study group population</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/STATO_0000203 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/STATO_0000203">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000193"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/PopulationSize"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UBERON_0000061 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">anatomical structure</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UBERON_0001062 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001062">
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/hp.owl"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">anatomical entity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000001">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of the distance between two points.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000001</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">length unit</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000002 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000002">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of the amount of matter/energy of a physical object.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000002</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mass unit</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000009 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000009">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000002"/>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000045"/>
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/UnitOfMeasurement"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">kg</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000009</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/uo#unit_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">kilogram</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000015 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000015">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UO_0000001"/>
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/UnitOfMeasurement"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A length unit which is equal to one hundredth of a meter or 10^[-2] m.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">centimetre</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cm</oboInOwl:hasExactSynonym>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000015</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/uo#unit_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">centimeter</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/UO_0000045 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000045">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is one of a particular measure to which all measures of that type can be related.</obo:IAO_0000115>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
<oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">george gkoutos</oboInOwl:created_by>
<oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">unit.ontology</oboInOwl:hasOBONamespace>
<oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UO:0000045</oboInOwl:id>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/uo#unit_group_slim"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">base unit</rdfs:label>
</owl:Class>
<!-- http://semanticscience.org/resource/Mean -->
<owl:Class rdf:about="http://semanticscience.org/resource/Mean">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#CentralTendencyMeasure"/>
<dct:source rdf:resource="https://en.wikipedia.org/wiki/Mean"/>
<rdfs:label>mean</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the central value of a discrete set of numbers: specifically, the sum of the values divided by the number of values</skos:definition>
</owl:Class>
<!-- http://semanticscience.org/resource/Median -->
<owl:Class rdf:about="http://semanticscience.org/resource/Median">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#CentralTendencyMeasure"/>
</owl:Class>
<!-- http://semanticscience.org/resource/MedicalIntervention -->
<owl:Class rdf:about="http://semanticscience.org/resource/MedicalIntervention"/>
<!-- http://semanticscience.org/resource/Patient -->
<owl:Class rdf:about="http://semanticscience.org/resource/Patient">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/ElectronicHealthRecord"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasProperty"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DOID_4"/>
</owl:Restriction>
</rdfs:subClassOf>
<dct:source>https://www.tititudorancea.com/z/patient_en.htm</dct:source>
<rdfs:label>patient</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary</skos:definition>
</owl:Class>
<!-- http://semanticscience.org/resource/Person -->
<owl:Class rdf:about="http://semanticscience.org/resource/Person">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/SubjectCharacteristic"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://semanticscience.org/resource/StandardDeviation -->
<owl:Class rdf:about="http://semanticscience.org/resource/StandardDeviation">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#DispersionMeasure"/>
<dct:source rdf:resource="https://en.wikipedia.org/wiki/Standard_deviation"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">standard deviation</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a measure that is used to quantify the amount of variation or dispersion of a set of data values</skos:definition>
</owl:Class>
<!-- http://semanticscience.org/resource/Study -->
<owl:Class rdf:about="http://semanticscience.org/resource/Study"/>
<!-- http://semanticscience.org/resource/StudySubject -->
<owl:Class rdf:about="http://semanticscience.org/resource/StudySubject">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasProperty"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DOID_4"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasProperty"/>
<owl:someValuesFrom rdf:resource="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasProperty"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/EnrollmentStatus"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/isParticipantIn"/>
<owl:someValuesFrom rdf:resource="http://hadatac.org/ont/hasco#ResearchStudy"/>
</owl:Restriction>
</rdfs:subClassOf>
<dct:source>https://en.wikipedia.org/wiki/Research_participant</dct:source>
<rdfs:label>study subject</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A research participant, also called a human subject or an experiment, trial, or study participant or subject, is a person who participates in human subject research by being the target of observation by researchers</skos:definition>
</owl:Class>
<!-- http://semanticscience.org/resource/UnitOfMeasurement -->
<owl:Class rdf:about="http://semanticscience.org/resource/UnitOfMeasurement">
<rdfs:label>unit of measurement</rdfs:label>
</owl:Class>
<!-- http://semanticscience.org/resource/Year -->
<owl:Class rdf:about="http://semanticscience.org/resource/Year">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/UnitOfMeasurement"/>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#CentralTendencyMeasure -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#CentralTendencyMeasure">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<rdfs:comment>Statistical measure describing the distribution of single variable</rdfs:comment>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#ClinicalIntervention -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#ClinicalIntervention">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
<rdfs:seeAlso>http://purl.bioontology.org/ontology/SNOMEDCT/386053000</rdfs:seeAlso>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#DataAnalysisInstrument -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#DataAnalysisInstrument"/>
<!-- http://www.case.edu/ProvCaRe/provcare#DispersionMeasure -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#DispersionMeasure">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<rdfs:comment>Statistical measure characterizing the distribution of single variable</rdfs:comment>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#Intervention -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#Intervention">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StudyMethod"/>
<rdfs:comment>Capturing the interventions variables in research studies</rdfs:comment>
<rdfs:comment>The intervention type used in a research study (corresponding to I in the PICO(T) model )</rdfs:comment>
<rdfs:label>study intervention</rdfs:label>
<rdfs:seeAlso>http://purl.bioontology.org/ontology/SNOMEDCT/386053000</rdfs:seeAlso>
<rdfs:synonym>Study intervention</rdfs:synonym>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#DataAnalysisInstrument"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:allValuesFrom rdf:resource="http://semanticscience.org/resource/UnitOfMeasurement"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasValue"/>
<owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#decimal"/>
</owl:Restriction>
</rdfs:subClassOf>
<dct:source rdf:resource="https://en.wikipedia.org/wiki/Measure"/>
<rdfs:label>statistical measure</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a standard unit used to express the size, amount, or degree of something</skos:definition>
</owl:Class>
<!-- http://www.case.edu/ProvCaRe/provcare#StudyMethod -->
<owl:Class rdf:about="http://www.case.edu/ProvCaRe/provcare#StudyMethod"/>
<!-- http://www.w3.org/2002/07/owl#DataProperty -->
<owl:Class rdf:about="http://www.w3.org/2002/07/owl#DataProperty"/>
<!-- http://www.w3.org/2004/02/skos/core#definition -->
<owl:Class rdf:about="http://www.w3.org/2004/02/skos/core#definition"/>
<!-- https://purl.org/heals/sco/Active -->
<owl:Class rdf:about="https://purl.org/heals/sco/Active">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/EnrollmentStatus"/>
<dct:title>Clinical Trials Protocol Template - NIH Office of Science Policy</dct:title>
<fibo-fnd-utl-av:adaptedFrom>https://osp.od.nih.gov/wp-content/uploads/2014/01/Protocol_Template_05Feb2016_508.pdf</fibo-fnd-utl-av:adaptedFrom>
<rdfs:label>active</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">participants following clinical trial protocol</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/CohortDescription -->
<owl:Class rdf:about="https://purl.org/heals/sco/CohortDescription">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/Dataset"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasDataItem"/>
<owl:someValuesFrom rdf:resource="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasDataItem"/>
<owl:someValuesFrom rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasDataItem"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/StudyArm"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasDataItem"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/SubjectCharacteristic"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:comment>All typical components that constitute the description of study populations, captured in the first table of a research study, and hence called Table 1s</rdfs:comment>
<rdfs:label>cohort description</rdfs:label>
<rdfs:synonym>Table 1</rdfs:synonym>
</owl:Class>
<!-- https://purl.org/heals/sco/ControlArm -->
<owl:Class rdf:about="https://purl.org/heals/sco/ControlArm">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/StudyArm"/>
</owl:Class>
<!-- https://purl.org/heals/sco/Discontinued -->
<owl:Class rdf:about="https://purl.org/heals/sco/Discontinued">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/EnrollmentStatus"/>
<dct:title>Clinical Trials Protocol Template - NIH Office of Science Policy</dct:title>
<fibo-fnd-utl-av:adaptedFrom>https://osp.od.nih.gov/wp-content/uploads/2014/01/Protocol_Template_05Feb2016_508.pdf</fibo-fnd-utl-av:adaptedFrom>
<rdfs:label>discontinued</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">participants no longer, following clinical trial protocol</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/Duration -->
<owl:Class rdf:about="https://purl.org/heals/sco/Duration"/>
<!-- https://purl.org/heals/sco/ElectronicHealthRecord -->
<owl:Class rdf:about="https://purl.org/heals/sco/ElectronicHealthRecord">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/Dataset"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="http://hadatac.org/ont/chear#Anthropometry"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="http://hadatac.org/ont/chear#Demographic"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="https://purl.org/heals/sco/OrderedLaboratoryTestResult"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasProperty"/>
<owl:someValuesFrom rdf:resource="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
</owl:Restriction>
</rdfs:subClassOf>
<dct:source rdf:resource="https://www.healthit.gov/faq/what-electronic-health-record-ehr"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">electronic health record</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a digital version of a patient’s paper chart</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/EnrollmentStatus -->
<owl:Class rdf:about="https://purl.org/heals/sco/EnrollmentStatus">
<rdfs:subClassOf rdf:resource="http://semanticscience.org/resource/StatusDescriptor"/>
<fibo-fnd-utl-av:adaptedFrom>https://research-compliance.umich.edu/sites/default/files/resource-download/enrollmentdefinition_additionalhelp.pdf</fibo-fnd-utl-av:adaptedFrom>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">enrollment status</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">patients are consented and screened, with eligibility verified</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/IntentionToTreatPopulation -->
<owl:Class rdf:about="https://purl.org/heals/sco/IntentionToTreatPopulation">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000203"/>
<dct:source>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159210/</dct:source>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">intention to treat population</rdfs:label>
<skos:definition>every subject who is randomized according to randomized treatment assignment, ignoring noncompliance, protocol deviations, withdrawal, and anything that happens after randomization</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/InterventionArm -->
<owl:Class rdf:about="https://purl.org/heals/sco/InterventionArm">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/StudyArm"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#subClassOf"/>
<owl:someValuesFrom rdf:resource="http://semanticscience.org/resource/StudySubject"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- https://purl.org/heals/sco/Meta-analysis -->
<owl:Class rdf:about="https://purl.org/heals/sco/Meta-analysis">
<rdfs:subClassOf rdf:resource="http://hadatac.org/ont/hasco#ResearchStudy"/>
</owl:Class>
<!-- https://purl.org/heals/sco/OrderedLaboratoryTestResult -->
<owl:Class rdf:about="https://purl.org/heals/sco/OrderedLaboratoryTestResult">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/SubjectCharacteristic"/>
<rdfs:label>laboratory test result</rdfs:label>
</owl:Class>
<!-- https://purl.org/heals/sco/PopulationSize -->
<owl:Class rdf:about="https://purl.org/heals/sco/PopulationSize">
<rdfs:subClassOf rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasValue"/>
<owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#integer"/>
</owl:Restriction>
</rdfs:subClassOf>
<fibo-fnd-utl-av:adaptedFrom>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296634/</fibo-fnd-utl-av:adaptedFrom>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">population size</rdfs:label>
<skos:definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">number of patients to which the study results could be reasonably generalized</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/RandomizedPopulation -->
<owl:Class rdf:about="https://purl.org/heals/sco/RandomizedPopulation">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000203"/>
</owl:Class>
<!-- https://purl.org/heals/sco/SafetyPopulation -->
<owl:Class rdf:about="https://purl.org/heals/sco/SafetyPopulation">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000203"/>
</owl:Class>
<!-- https://purl.org/heals/sco/StudyArm -->
<owl:Class rdf:about="https://purl.org/heals/sco/StudyArm">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/STATO_0000203"/>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/DOID_4"/>
<rdf:Description rdf:about="http://www.case.edu/ProvCaRe/provcare#Intervention"/>
<rdf:Description rdf:about="https://purl.org/heals/sco/SubjectCharacteristic"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="http://www.case.edu/ProvCaRe/provcare#StatisticalMeasure"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasValue"/>
<owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#decimal"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
</owl:Class>
<!-- https://purl.org/heals/sco/SubjectCharacteristic -->
<owl:Class rdf:about="https://purl.org/heals/sco/SubjectCharacteristic">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="http://semanticscience.org/resource/DimensionalQuantity"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasAttribute"/>
<owl:someValuesFrom rdf:resource="http://semanticscience.org/resource/UnitOfMeasurement"/>
</owl:Restriction>
</rdfs:subClassOf>
<dct:source>R. J. Little et al., "The prevention and treatment of missing data in clinical trials," New England J. Medicine, vol. 367, no. 14, pp. 1355{1360, 2012</dct:source>
<rdfs:label>subject characteristic</rdfs:label>
<skos:definition>Property that summarizes important attributes of the participants enrolled in a study</skos:definition>
</owl:Class>
<!-- https://purl.org/heals/sco/YearOfFollowUp -->
<owl:Class rdf:about="https://purl.org/heals/sco/YearOfFollowUp">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/Duration"/>
</owl:Class>
<!-- https://purl.org/heals/sco/YearsOfExposure -->
<owl:Class rdf:about="https://purl.org/heals/sco/YearsOfExposure">
<rdfs:subClassOf rdf:resource="https://purl.org/heals/sco/Duration"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://semanticscience.org/resource/hasUnit"/>
<owl:someValuesFrom rdf:resource="http://semanticscience.org/resource/Year"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Individuals
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://hadatac.org/ont/hasco#ResearchStudy -->
<owl:NamedIndividual rdf:about="http://hadatac.org/ont/hasco#ResearchStudy">
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid40">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<sio:hasValue>A scientific investigation that involves testing a hypothesi</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>A scientific study of nature that sometimes includes processes involved in health and disease</sio:hasValue>
<dct:source rdf:resource="https://www.healthcareers.nhs.uk/explore-roles/healthcare-science/roles-healthcare-science/physical-sciences-and-biomedical-engineering/clinical-measurement"/>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/NCIT_C71104 -->
<owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/NCIT_C71104">
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid42">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<sio:hasValue>A prospective study designed to evaluate whether one or more interventions are associated with an outcome</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid43">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<sio:hasValue>A prospective study designed to evaluate whether one or more interventions are associated with an outcome</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/STATO_0000203 -->
<owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/STATO_0000203">
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid44">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<sio:hasValue>A cohort is the group of subjects enrolled in a study"</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid45">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://tw.rpi.edu/web/People/JamesMcCusker"/>
<sio:hasValue>"Top-level group of subjects participating in a study"</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- http://semanticscience.org/resource/hasValue -->
<owl:NamedIndividual rdf:about="http://semanticscience.org/resource/hasValue">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#DataProperty"/>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/ControlArm -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/ControlArm">
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>An arm type that can receive an intervention that is considered effective (the standard), a placebo, or no intervention</sio:hasValue>
<fibo-fnd-utl-av:adaptedFrom>https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/3392/control-arm</fibo-fnd-utl-av:adaptedFrom>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/InterventionArm -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/InterventionArm">
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>An arm type in which a group of participants receives the intervention/treatment that is the focus of the clinical trial</sio:hasValue>
<dct:source>https://clinicaltrials.gov/ct2/about-studies/glossary</dct:source>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/Meta-analysis -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/Meta-analysis">
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>A quantitative, formal, epidemiological study design used to systematically assess previous research studies to derive conclusions about that body of research</sio:hasValue>
<dct:source>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049418/</dct:source>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/RandomizedPopulation -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/RandomizedPopulation">
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>set of patients recruited for research studies, who are randomly assigned to different study groups, intending to ensure that all potential confounding factors are divided equally among the groups that will later be compared (structural equivalence)</sio:hasValue>
<fibo-fnd-utl-av:adaptedFrom>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196997/</fibo-fnd-utl-av:adaptedFrom>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/SafetyPopulation -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/SafetyPopulation">
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>set of patients recruited for research studies, who are a part of the experimental treatment population, additionally patients receiving the experimental intervention is analyzed with the experimental group</sio:hasValue>
<fibo-fnd-utl-av:adaptedFrom>https://www.dummies.com/education/science/biology/how-to-define-analytical-populations-for-a-clinical-study/</fibo-fnd-utl-av:adaptedFrom>
<fibo-fnd-utl-av:adaptedFrom>https://www.ncbi.nlm.nih.gov/books/NBK209903/</fibo-fnd-utl-av:adaptedFrom>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://purl.org/heals/sco/StudyArm -->
<owl:NamedIndividual rdf:about="https://purl.org/heals/sco/StudyArm">
<sio:hasAttribute>
<rdf:Description rdf:nodeID="genid51">
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<prov:wasAttributedTo rdf:resource="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<sio:hasValue>An arm in a clinical trial is a group of subjects receiving the same therapeutic intervention (or none)</sio:hasValue>
</rdf:Description>
</sio:hasAttribute>
<sio:hasAttribute>
<rdf:Description>
<rdf:type rdf:resource="http://www.w3.org/2004/02/skos/core#definition"/>
<sio:hasValue>A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.</sio:hasValue>
<dct:source>https://clinicaltrials.gov/ct2/about-studies/glossary</dct:source>
</rdf:Description>
</sio:hasAttribute>
</owl:NamedIndividual>
<!-- https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas -->
<owl:NamedIndividual rdf:about="https://researcher.watson.ibm.com/researcher/view.php?person=us-amardas"/>
<!-- https://tw.rpi.edu/web/People/JamesMcCusker -->
<owl:NamedIndividual rdf:about="https://tw.rpi.edu/web/People/JamesMcCusker"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotations
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<rdf:Description rdf:about="http://hadatac.org/ont/chear#NonHispanicOrLatino">
<oboInOwl:hasExactSynonym>Non-Hispanic</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="http://hadatac.org/ont/chear#UnknownRace">
<oboInOwl:hasExactSynonym>Other Race</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="http://hadatac.org/ont/hasco#ResearchStudy">
<rdfs:label>research study</rdfs:label>
<rdfs:label>study</rdfs:label>
</rdf:Description>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCIT_C16352">
<oboInOwl:hasExactSynonym>Black</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCIT_C17459">
<oboInOwl:hasExactSynonym>Hispanic</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Hispanic Populations</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Hispanic or Latino</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Hispanics or Latinos</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Latino Population</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Spanish Origins</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCIT_C41219">
<oboInOwl:hasExactSynonym>Hawaiiaan</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Pacific Islander</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Hawaiian or Pacific Islander</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCIT_C71104">
<obo:NCIT_P322>CDISC-GLOSS</obo:NCIT_P322>
<obo:NCIT_P106>Research Activity</obo:NCIT_P106>
<obo:NCIT_P325>1) A research investigation involving human subjects that is designed to answer specific questions about the safety and efficacy of a biomedical intervention (drug, treatment, device) or new ways of using a known drug, treatment, or device). 2) A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes.(1. modified from ICH E6 Glossary, Directive 2001/20/EC. 2. NIH revised definition 2015) (CDISC Glossary)</obo:NCIT_P325>
<oboInOwl:hasExactSynonym>Clinical Trial</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>clinical trial</oboInOwl:hasExactSynonym>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132310"/>
<obo:NCIT_P325>A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease.</obo:NCIT_P325>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C132298"/>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C67497"/>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncit.owl"/>
<oboInOwl:hasExactSynonym>Clinical Trials</oboInOwl:hasExactSynonym>
<obo:NCIT_NHC0>C71104</obo:NCIT_NHC0>
<rdfs:label>clinical trial</rdfs:label>
<obo:NCIT_P322>CDISC</obo:NCIT_P322>
<obo:IAO_0000115>A research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes.</obo:IAO_0000115>
<obo:NCIT_P207>C0008976</obo:NCIT_P207>
<obo:NCIT_P325>A research investigation involving human subjects that is designed to answer specific questions about the safety and efficacy of a biomedical intervention (drug, treatment, device) or new ways of using a known drug, treatment, or device). NOTE: NIH Office of Science Policy further specifies that a clinical trial is a type of research study that prospectively assigns subjects to interventions, and the EU clinical trial regulations set forth 3 specific conditions, any one of which qualifies a study as a clinical trial. These conditions include applying diagnostic or monitoring procedures not used in normal clinical practice to subjects. [after ICH E6 [R2], EU CTR 2014] See also clinical study, clinical investigation.</obo:NCIT_P325>
<oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C61410"/>
<oboInOwl:hasExactSynonym>Clinical Trials, Unspecified</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Trial</oboInOwl:hasExactSynonym>
<obo:NCIT_P366>Clinical_Trial_Generic</obo:NCIT_P366>
<obo:NCIT_P108>Clinical Trial</obo:NCIT_P108>
</rdf:Description>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/STATO_0000203">
<obo:IAO_0000112 xml:lang="en"></obo:IAO_0000112>
<obo:IAO_0000119 xml:lang="en">STATO</obo:IAO_0000119>
<obo:STATO_0000032 xml:lang="en"></obo:STATO_0000032>
<obo:IAO_0000115 xml:lang="en">a cohort is a study group population where the members are human beings which meet inclusion criteria and undergo a longitudinal design</obo:IAO_0000115>
<obo:IAO_0000117>Orlaith Burke</obo:IAO_0000117>
<obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/stato.owl"/>
<rdfs:label>cohort</rdfs:label>
<obo:IAO_0000116 xml:lang="en">possibly submit to 'Population and Community Ontology'</obo:IAO_0000116>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
<obo:IAO_0000117 xml:lang="en">Alejandra Gonzalez-Beltran</obo:IAO_0000117>
</rdf:Description>
<rdf:Description rdf:about="http://purl.org/twc/ontologies/cmo.owl#0000105">
<oboInOwl:hasExactSynonym>BMI</oboInOwl:hasExactSynonym>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/ControlArm">
<rdfs:seeAlso>http://semanticscience.org/resource/SIO_001068.rdf</rdfs:seeAlso>
<rdfs:label>control arm</rdfs:label>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/InterventionArm">
<rdfs:label>intervention arm</rdfs:label>
<rdfs:seeAlso>http://semanticscience.org/resource/SIO_001069.rdf</rdfs:seeAlso>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/Meta-analysis">
<rdfs:label>meta-analysis</rdfs:label>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/RandomizedPopulation">
<rdfs:label>randomized population</rdfs:label>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/SafetyPopulation">
<rdfs:label>safety population</rdfs:label>
</rdf:Description>
<rdf:Description rdf:about="https://purl.org/heals/sco/StudyArm">
<rdfs:label>study arm</rdfs:label>
</rdf:Description>
</rdf:RDF>
<!-- Generated by the OWL API (version 4.5.9.2019-02-01T07:24:44Z) https://github.com/owlcs/owlapi -->