tool group n pos AUROC AUPRC SIFT all 22203 4003 0.7783889349471413 0.4421438544842223 SIFT oncogene 5337 1434 0.7640829694713254 0.5199893513025153 SIFT TSG 10158 1236 0.8166938439507011 0.38339650145213555 SIFT4G all 20519 3977 0.8082608781171217 0.540524687630165 SIFT4G oncogene 5362 1426 0.7859545683246103 0.5715910282592398 SIFT4G TSG 9765 1221 0.8474785434055098 0.4706199108767246 Polyphen2_HDIV all 22281 3926 0.8135184445335965 0.4698929726174499 Polyphen2_HDIV oncogene 5347 1343 0.8052620313417037 0.5411908587378504 Polyphen2_HDIV TSG 10121 1248 0.8465252281481994 0.40930704437280485 Polyphen2_HVAR all 22281 3926 0.8260854200974637 0.5501114457446966 Polyphen2_HVAR oncogene 5347 1343 0.8200104995525697 0.6024320707462961 Polyphen2_HVAR TSG 10121 1248 0.8521619263423755 0.4815117820408987 MutationTaster all 21066 3653 0.846536633750874 0.6762030293336887 MutationTaster oncogene 5278 1425 0.8681042341124026 0.7785208910707159 MutationTaster TSG 9509 1179 0.8969553724797807 0.6161387669236007 MutationAssessor all 22099 3890 0.7937255807708863 0.5542967724320108 MutationAssessor oncogene 5429 1382 0.7686979009661085 0.6041014175632554 MutationAssessor TSG 10047 1181 0.8239823599961262 0.5351708984826172 PROVEAN all 22230 4021 0.8185524745702887 0.5876658555631475 PROVEAN oncogene 5338 1435 0.8128212819407211 0.6457049369408885 PROVEAN TSG 10182 1252 0.8589171100036134 0.5478132768916758 VEST4 all 22427 4027 0.8327820094794917 0.6479563246143231 VEST4 oncogene 5365 1430 0.839665099830284 0.7129254014371775 VEST4 TSG 10245 1251 0.8845263126834535 0.626329790455385 MetaSVM all 23098 4125 0.7620637876152555 0.5069701247532967 MetaSVM oncogene 5733 1490 0.7656660713975012 0.5627618425827581 MetaSVM TSG 10321 1263 0.7940255522298718 0.4996560806989369 MetaLR all 23098 4125 0.7477352984863659 0.5442937194474687 MetaLR oncogene 5733 1490 0.7501042380106516 0.5426882927795919 MetaLR TSG 10321 1263 0.7878182599791927 0.5219568613427403 MetaRNN all 22922 4097 0.8526020367314405 0.7333156100520049 MetaRNN oncogene 5751 1485 0.8870795784063482 0.7927172481253376 MetaRNN TSG 10344 1261 0.8893939868843705 0.714934228837229 M-CAP all 20708 3876 0.7577946737405188 0.48092474901926285 M-CAP oncogene 5096 1453 0.7746635875418622 0.5441770148736746 M-CAP TSG 9463 1223 0.8028293171335805 0.4783423690604408 REVEL all 22298 4047 0.8161422000063172 0.6521567785065284 REVEL oncogene 5393 1483 0.8426920271172177 0.7386205041710758 REVEL TSG 10226 1252 0.8593672455250561 0.6179991989092155 MutPred2 all 22978 4096 0.8456199863378483 0.6641621179212789 MutPred2 oncogene 5530 1437 0.8759344543470096 0.7726822439393 MutPred2 TSG 10325 1260 0.8956129453068229 0.6609761942567666 MVP all 21531 3828 0.8066745944092858 0.5702986433439902 MVP oncogene 5180 1450 0.8154185079042249 0.6574538039818139 MVP TSG 10000 1219 0.8029502695197579 0.5018908706365559 gMVP all 22370 4034 0.8502867830032854 0.6754428158729421 gMVP oncogene 5449 1434 0.8601853058005978 0.739268250013035 gMVP TSG 10060 1209 0.9129092346698522 0.7311718625827013 MisFit_D all 22831 4058 0.8386548446030402 0.657302059374361 MisFit_D oncogene 5748 1482 0.8456157433505866 0.7228429339809482 MisFit_D TSG 10129 1189 0.8828922561963412 0.6622022015914757 MisFit_S all 22831 4058 0.728768137403169 0.5488806110745832 MisFit_S oncogene 5748 1482 0.8029436532656609 0.6945944490167513 MisFit_S TSG 10129 1189 0.8459311962941429 0.634572610013892 MPC all 20062 3737 0.8225925587467898 0.6129276589432756 MPC oncogene 4778 1347 0.8419588896123104 0.7164388726678919 MPC TSG 9044 1123 0.8731222491740849 0.6255977843773552 PrimateAI all 23027 4105 0.7968600116305401 0.5080723156946669 PrimateAI oncogene 5709 1481 0.8167279070049707 0.617598395817322 PrimateAI TSG 10259 1254 0.8715339785534707 0.504628016594528 DEOGEN2 all 22599 4008 0.8146056201297582 0.6529912040591326 DEOGEN2 oncogene 5400 1362 0.8577175969261182 0.7320030879023922 DEOGEN2 TSG 10224 1246 0.8412275038644491 0.5961924949293914 BayesDel_addAF all 23222 4140 0.864093415551596 0.7119491027797276 BayesDel_addAF oncogene 5745 1492 0.8777503058872179 0.7639734336826562 BayesDel_addAF TSG 10352 1270 0.8915122410513484 0.684070582783628 BayesDel_noAF all 23222 4140 0.824848321786422 0.6486577862427525 BayesDel_noAF oncogene 5745 1492 0.8272694593754668 0.6879365414884534 BayesDel_noAF TSG 10352 1270 0.8668235776572852 0.6296691540766449 ClinPred all 23151 4137 0.8694856256317781 0.7410433121046296 ClinPred oncogene 5745 1492 0.8880481937052478 0.7893833336686696 ClinPred TSG 10350 1270 0.8983122029900448 0.7169656571837322 LIST-S2 all 22377 4148 0.7675663487868076 0.5211718736439552 LIST-S2 oncogene 5704 1488 0.7556515533502682 0.5622483370817621 LIST-S2 TSG 9633 1259 0.8324354592005628 0.5360137941107234 VARITY_R all 21164 3955 0.8743660209549894 0.7449776457367305 VARITY_R oncogene 5425 1391 0.8940679280037723 0.8044391758734507 VARITY_R TSG 9051 1227 0.8942277163614183 0.6898944434862687 VARITY_ER all 21164 3955 0.8673560985457365 0.717007464480502 VARITY_ER oncogene 5425 1391 0.88590875830067 0.7795532970686465 VARITY_ER TSG 9051 1227 0.8858758831205844 0.657946703361872 VARITY_R_LOO all 21164 3955 0.8725674515855821 0.7392871030862354 VARITY_R_LOO oncogene 5425 1391 0.8912921867932779 0.7984612499278266 VARITY_R_LOO TSG 9051 1227 0.8927209530619014 0.6833106087688268 VARITY_ER_LOO all 21164 3955 0.866364673058279 0.7138131047325103 VARITY_ER_LOO oncogene 5425 1391 0.8840328986504716 0.7747239226079738 VARITY_ER_LOO TSG 9051 1227 0.8855329160854195 0.6564703792222433 ESM1b all 23322 4164 0.841866981526492 0.6406439413138619 ESM1b oncogene 5765 1491 0.8413507091527483 0.7190904263343948 ESM1b TSG 10381 1270 0.8580774559090552 0.5943824345298883 AlphaMissense all 22791 4123 0.8679010779054052 0.7500001035220522 AlphaMissense oncogene 5761 1490 0.884840558849365 0.8044227911560782 AlphaMissense TSG 9881 1231 0.8997205148312148 0.7494612410218056 PHACTboost all 21505 4090 0.8325595996481688 0.6929943333540144 PHACTboost oncogene 5719 1479 0.8502081021087681 0.7452352665450609 PHACTboost TSG 9045 1228 0.8889987119861955 0.706923582927811 MutFormer all 23188 4128 0.6926088603817403 0.44552743227542635 MutFormer oncogene 5740 1491 0.7680322935494823 0.5817048463593634 MutFormer TSG 10334 1261 0.6550444264177432 0.28620013611571454 MutScore all 23197 4128 0.8760066144430202 0.753892191624398 MutScore oncogene 5768 1491 0.877287338715482 0.8087676992660259 MutScore TSG 10331 1263 0.8976676529684575 0.7204570590583838 popEVE all 15355 3272 0.8597571589699364 0.7168078638020816 popEVE oncogene 4895 1334 0.9003207957941839 0.8338873815884817 popEVE TSG 6875 888 0.8419454614126403 0.6135357998799162 CADD_raw all 23334 4168 0.8259580079527427 0.5959170138514386 CADD_raw oncogene 5773 1492 0.8209680782909458 0.6423340222041513 CADD_raw TSG 10381 1270 0.8936755950451863 0.6463232505448057 DANN all 23234 4140 0.7622384918448216 0.3885769960135695 DANN oncogene 5746 1492 0.7485341032127466 0.46753429341064845 DANN TSG 10362 1270 0.8232404709860014 0.37753209565528345 fathmm-XF_coding all 21608 4041 0.8129438313922586 0.5678748883418329 fathmm-XF_coding oncogene 5617 1461 0.8099943246909213 0.6437656640975354 fathmm-XF_coding TSG 9429 1228 0.8568864446895528 0.47619901018286553 Eigen-raw_coding all 21619 4033 0.8142221433212391 0.5888586820426918 Eigen-raw_coding oncogene 5623 1471 0.808526584617964 0.6330456968510026 Eigen-raw_coding TSG 9499 1236 0.8740366753653261 0.6059938914751739 Eigen-PC-raw_coding all 21619 4033 0.7994948222146253 0.557396689384153 Eigen-PC-raw_coding oncogene 5623 1471 0.7950104558392244 0.6073177013089203 Eigen-PC-raw_coding TSG 9499 1236 0.8651272076128348 0.57364521255889 GERPpp_RS all 23223 4136 0.687297469927733 0.284989439672233 GERPpp_RS oncogene 5740 1489 0.6580135452662425 0.34928039719465676 GERPpp_RS TSG 10358 1270 0.7572010248003771 0.25294478519058894 GERP_92_mammals all 17600 2591 0.6908502139164205 0.2599236866657227 GERP_92_mammals oncogene 4198 901 0.6623825109902151 0.33281837857009766 GERP_92_mammals TSG 7902 736 0.7415431339416811 0.198318541967072 phyloP100way_vertebrate all 23334 4168 0.7638993735507716 0.4698223007096842 phyloP100way_vertebrate oncogene 5773 1492 0.7656781821039784 0.566764449737914 phyloP100way_vertebrate TSG 10381 1270 0.8176818365271019 0.4215203925739223 phyloP470way_mammalian all 22163 3857 0.7294678847232798 0.34738185055014675 phyloP470way_mammalian oncogene 5425 1408 0.7143206712381469 0.43734318617860685 phyloP470way_mammalian TSG 10076 1178 0.7856152982242437 0.31020847827708287 phyloP17way_primate all 23334 4168 0.5884074395577742 0.21126862193323534 phyloP17way_primate oncogene 5773 1492 0.591961613538968 0.2942190446344985 phyloP17way_primate TSG 10381 1270 0.610183891238159 0.15232158256855885 phastCons100way_vertebrate all 23334 4168 0.6784616254531828 0.26781166317225436 phastCons100way_vertebrate oncogene 5773 1492 0.6713305659460438 0.3571065116586228 phastCons100way_vertebrate TSG 10381 1270 0.7201765279833929 0.2064406795637382 phastCons470way_mammalian all 23294 4152 0.6475137505438011 0.24360168440304572 phastCons470way_mammalian oncogene 5759 1488 0.6363829546856393 0.3298899851812772 phastCons470way_mammalian TSG 10377 1270 0.69280072696524 0.18980019756989905 phastCons17way_primate all 23334 4168 0.6301163133171486 0.26486153246725913 phastCons17way_primate oncogene 5773 1492 0.6801456244406827 0.40483265016993203 phastCons17way_primate TSG 10381 1270 0.6671367655434246 0.20379574984514928 bStatistic all 23251 4146 0.4378469367181871 0.16037149318550525 bStatistic oncogene 5767 1492 0.42543538246868295 0.24472174455718448 bStatistic TSG 10364 1262 0.3835016842051746 0.09508701323181368