Yuki Yamagata
yuki.yamagata at riken.jp
Elucidating the mechanism of toxicity is crucial in drug safety evaluations. TOXic Process Ontology (TXPO) systematizes a wide variety of terms involving toxicity courses and processes. The first version of TXPO focuses on liver toxicity.
The TXPO contains an is-a hierarchy that is organized into three layers: the top layer contains general terms, mostly derived from the Basic Formal Ontology. The intermediate layer contains biomedical terms in OBO foundry from UBERON, Cell Ontology, NCBI Taxon, ChEBI, Gene Ontology, PATO, OGG, INOH, HINO, NCIT, DOID and Relational ontology (RO). The lower layer contains toxicological terms.
In applied work, we have developed a prototype of TOXPILOT, a TOXic Process InterpretabLe knOwledge sysTem. TOXPILOT provides visualization maps of the toxic course, which facilitates capturing the comprehensive picture for understanding toxicity mechanisms. A prototype of TOXPILOT is available: https://toxpilot.nibiohn.go.jp
http://creativecommons.org/licenses/by/4.0/
TOXic Process Ontology (TXPO)
An extension version ontology, which focuses on the homeostasis imbalance process affected by drugs, viruses, and other factors, is available: Homeostasis imbalance process (HoIP)
ontology
https://bioportal.bioontology.org/ontologies/HOIP
2022/12/07
editor preferred term
example of usage
has curation status
definition
editor note
term editor
alternative term
definition source
curator note
imported from
For external terms/classes, the ontology from which the term was imported
PERSON:Alan Ruttenberg
PERSON:Melanie Courtot
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
imported from
elucidation
has associated axiom(nl)
has associated axiom(fol)
has axiom label
the symbol assigned by the nomenclature authority
symbol from nomenclature authority
full name from nomenclature authority
A GeneID in the NCBI Gene database
NCBI GeneID
the NCBI LocusTag name of a gene
NCBI LocusTag
gene map location
The NCBITaxon ontology ID of an organism.
organism NCBITaxon ID
chromosome ID of gene
nomenclature status
has GO association
has PubMed association
X is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
is opposite_of
external definition
Notes on the homology status of this class.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
homology notes
Notes on the how instances of this class vary across species.
taxon notes
Notes on the evolved function of instances of this class.
function_notes
Notes on the structure, composition or histology of instances of this class.
structure_notes
Notes on the ontogenic development of instances of this class.
development_notes
fma_set_term
formula
smiles
Recommended best practice is to use RFC 3066 [RFC3066],
which, in conjunction with ISO 639 [ISO639], defines two-
and three-letter primary language tags with optional
subtags. Examples include "en" or "eng" for English,
"akk" for Akkadian, and "en-GB" for English used in the
United Kingdom.
A language of the intellectual content of the resource.
Language
auto-generated-by
date
has_alternative_id
database_cross_reference
has_exact_synonym
has_narrow_synonym
has_related_synonym
is part of
my brain is part of my body (continuant parthood, two material entities)
my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
this day is part of this year (occurrent parthood)
a core relation that holds between a part and its whole
Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)
A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
http://www.obofoundry.org/ro/#OBO_REL:part_of
part_of
part of
my body has part my brain (continuant parthood, two material entities)
my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
a core relation that holds between a whole and its part
Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
has part
occurs in
b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
occurs_in
unfolds in
unfolds_in
Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
occurs in
a relation between a continuant and a process, in which the process takes place entirely within the independent continuant
[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
contains process
a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method.
is gene of organism
inheres in
this fragility inheres in this vase
this red color inheres in this apple
a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
A dependent inheres in its bearer at all times for which the dependent exists.
inheres_in
inheres in
a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
bearer_of
is bearer of
bearer of
participates in
this blood clot participates in this blood coagulation
this input material (or this output material) participates in this process
this investigator participates in this investigation
a relation between a continuant and a process, in which the continuant is somehow involved in the process
participates_in
participates in
a relation between a process and a continuant, in which the continuant is somehow involved in the process
Example:
Protein refolding process hasParticipant "GRP78/Bip" that has a chaperon role .
http://www.obofoundry.org/ro/#OBO_REL:has_participant
has participant
this catalysis function is a function of this enzyme
A relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
function_of
is_function_of
function of
this red color is a quality of this apple
a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
A quality inheres in its bearer at all times for which the quality exists.
is quality of
quality_of
quality of
this investigator role is a role of this person
a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
is role of
role_of
role of
a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
has function
a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
hasQuality is a relation between an entity and the quality that it bears.
has_quality
has quality
a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
has_role
A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
has role
A part of relation that applies only between occurents.
is occurent part of
occurent part of
relation between an artery and the structure is supplies with blood
supplies
W 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
has component
process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
regulates
Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
negatively regulates
Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
positively regulates
P has output c iff c is a participant in p, c is present at the beginning of p.
has input
P has output c iff c is a participant in p, c is present at the end of p
has output
inverse of regulates: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
regulated by
inverse of negatively regulates:
Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
negatively regulated by
inverse of positively regulates:
Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
positively regulated by
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.
has target start location
RO:0002339
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination.
has target end location
An organism that is a member of a population of organisms
is member of is a mereological relation between a item and a collection.
is member of
member part of
SIO
member of
has member is a mereological relation between a collection and an item.
has member
'input of' is a relation between a participant and a process, where the participant is present at the start of the process.
is input of
input of
'output of' is a relation between a participant and a process, where the participant is present at the end of the process.
is output of
output_of
output of
p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
causally upstream of or within
inverse of causally upstream of or within:
p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
causally downstream of or within
x composed_primarily_of_y if:more than half of the mass of x is made from parts of y
composed_primarily_of
p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
http://purl.obolibrary.org/obo/ro/docs/causal-relations
causal relation between processes
Holds between c and p if and only if c is capable of some activity a, and a regulates p.
capable of regulating
Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
capable of positively regulating
Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
capable of negatively regulating
a relation between a toxic course (the bearer) and a process.
Core process is a crucial process to the manifestation of toxicity and depends on the bearer for its existence.
has core process
has core process
'Metafunctioning type of' is a relation between the type of metafunctioning and functioning process.
Metafunctioning is a functional process to other process, for example, preventing, controlling and so on.
is metafuntioning type of
is_metafuntioning_type_of
metafuntioning type of
'has molecular reaction' is a relation that holds between a whole occurrent (process) and its molecular process.
has molecular reaction
'finding of' is a relation between a finding and an entity, where the finding is a representational artifact that a result of a laboratory test or an observation.
is finding of
finding of
'component of' is a relation between molecular components and a molecular complex.
component of
located_in
inverse of 'has cause':
p 'has cause' q if p exerts some causal influence on q directly, where p is a cause and q is its effect.
results in
has result
p 'has cause' q if p exerts some causal influence on q directly, where p is a cause and q is its effect.
has cause
'Relation between a role and a process' is a relationship that holds between a role of material entity and a process in which causality is involved, with either the material entity or some part of the material entity plays a role and some influence over the process.
relation between a role and a process
'manifested phenotype of' is a relation between a phenotype and an entity, where there is a bearer of the realizable entity that participates in the process, and the phenotype comes to be realized in the course of the process.
manifested phenotype of
This shattering realizes the fragility in the course of breaking the cup (process).
'mainfests phenotype' is a relation between an entity and quality, where there is a bearer of the realizable entity that participates in the process, and the phenotype comes to be realized in the course of the process.
manifests phenotype
Inherit means to receive a property (or an attribute and its value) from another entity (other than the ancestor) .
inherit
'has family member' is a relation between (molecule ) family and a molecule.
A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
has family member
A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
Wikipedia:Protein family
'dysfunctioning of' is a relation between an impaired or abnormal functioning and a normal functioning process.
is dysfuctioning of
dysfunctioning of
'molecular reaction of' is a relation that holds between a molecular process and its whole process.
is molecular reaction of
molecular_reaction_of
molecular reaction of
'relates assay' is a relation between an entity and the assay in which the entity was related (e.g., can be expressed, observed, and so on).
relateds assay
'has context' is a relation between an entity and its context dependent on.
Role is intrinsically context-dependent.
has context
'has related human gene' is a relation between a molecule and the related gene.
has related human gene
The cross-sectional area of the coronary artery has attribute value 'small.'
'has attribute value' is a relation between an attribute and its value.
has attribute value
'dysfunctioning of' is a relation between an increasing function process and a normal one.
hyperfunction of
'malfunctioning of' is a relation between an abnormal functioning and a normal functioning process.
malfunctioning of
has related rat gene
'has state' is a relation between an entity and the state.
has state
'has attribute' is a relation between an entity and its attribute, in which the attribute specifically depends on the bearer for its existence.
has attribute
'has agent' is a relation between a participant and a process, in which the participant is active in the relevant process.
Example: A protease is an agent in proteolysis process.
has agent
Metafunctioning type is a relation between functional process and the type of metafunction.
Metafunctioning is a functional process to other process, for example, preventing, controlling and so on.
metafunctioning type
'property of' is a relation between a property and the entity, , in which the property specifically depends on the bearer for its existence.
http://semanticscience.org/resource/SIO_000224
is property of
property of
'is attribute of' is a relation that associates an attribute with an entity.
is attribute of
is_attribute_of
attribute of
'has finding' is a relation between an entity and its finding, where the finding is a representational artifact that a result of a laboratory test or an observation.
has finding
Proteolysis is a context of the protease role of the molecule.
'context of' is a relation between a context and an entity.
Role is intrinsically context-dependent.
context of
'related assay of' is a relationship between an assay and the entity, in which the entity can be related (e.g., can be expressed, observed, and so on) in the assay like in vivo, in vitro or clinical test.
related assay of
'agent of' is a relation between a participant and a process, in which the participant is active in the relevant process.
is agent of
agent of
'famly of' is a relationship between a molecule and its family.
A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
family_of
family of
A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
Wikipedia:Protein family
"has ocurrent part" is a relation that holds between a whole occurrent (process) and its part.
has occurrent part
"has pathway" is a relation that holds between a whole occurrent (process) for signaling and its pathway.
has pathway
'pathway of' is a relation that holds between a pathway and its whole (signaling) process.
is pathway of
is_pathway_of
pathway_of
pathway of
'Is substance in organism' is a relation between substance and organism where the substance is existed in.
is entity in organism
'has dysfunctioning' is a relation between a normal functioning process and an impaired or abnormal functioning.
has_dysfunctioning
has dysfunctioning
'Attribute value of' is a relation between a value and its attribute
is attribute value of
attribute value of
observed in
A relation between a process/process sequence and a disease.
realizes disease
'channel for' is a relation between a channel that is a passage and an entity such a solvent (e.g., ion) to pass.
channel for
Julius Caesar
Verdi’s Requiem
the Second World War
your body mass index
BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
entity
Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
per discussion with Barry Smith
An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
continuant
Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
occurrent
occurrent
Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
per discussion with Barry Smith
Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
a chair
a heart
a leg
a molecule
a spatial region
an atom
an orchestra.
an organism
the bottom right portion of a human torso
the interior of your mouth
b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
independent continuant
b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
BFO 2 Reference: Spatial regions do not participate in processes.
Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]
spatial region
Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
per discussion with Barry Smith
A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]
Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]
temporal region
Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
per discussion with Barry Smith
A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]
an infinitely thin plane in space.
the surface of a sphere-shaped part of space
A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]
two-dimensional spatial region
A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]
the spatiotemporal region occupied by a human life
the spatiotemporal region occupied by a process of cellular meiosis.
the spatiotemporal region occupied by the development of a cancer tumor
A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
Every spatiotemporal region occupies_spatiotemporal_region itself.
Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
(forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
(forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
(forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
(forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
(forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]
spatiotemporal region
A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
(forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
(forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
(forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
(forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
(forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]
a process of cell-division, \ a beating of the heart
a process of meiosis
a process of sleeping
the course of a disease
the life of an organism
your process of aging.
p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
Superclass of unit process(primitive process) and senquence processes.
It is dissective and has no unity, and hence it can change.
It follows A-series of time.
(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
process
p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
Superclass of unit process(primitive process) and senquence processes.
It is dissective and has no unity, and hence it can change.
It follows A-series of time.
YAMATO ontology
(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
an atom of element X has the disposition to decay to an atom of element Y
certain people have a predisposition to colon cancer
children are innately disposed to categorize objects in certain ways.
the cell wall is disposed to filter chemicals in endocytosis and exocytosis
BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
disposition
b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
the disposition of this piece of metal to conduct electricity.
the disposition of your blood to coagulate
the function of your reproductive organs
the role of being a doctor
the role of this boundary to delineate where Utah and Colorado meet
To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
realizable entity
To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]
zero-dimensional spatial region
A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]
the ambient temperature of this portion of air
the color of a tomato
the length of the circumference of your waist
the mass of this piece of gold.
the shape of your nose
the shape of your nostril
a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
YAMATO:property
quality
a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
of one-sided specifically dependent continuants: the mass of this tomato
of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
the disposition of this fish to decay
the function of this heart: to pump blood
the mutual dependence of proton donors and acceptors in chemical reactions [79
the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
the pink color of a medium rare piece of grilled filet mignon at its center
the role of being a doctor
the shape of this hole.
the smell of this portion of mozzarella
b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
specifically dependent continuant
b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
per discussion with Barry Smith
(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
the priest role
the role of a boundary to demarcate two neighboring administrative territories
the role of a building in serving as a military target
the role of a stone in marking a property boundary
the role of subject in a clinical trial
the student role
BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
role
b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
the FMA:regional parts of an intact human body.
the Western hemisphere of the Earth
the division of the brain into regions
the division of the planet into hemispheres
the dorsal and ventral surfaces of the body
the upper and lower lobes of the left lung
BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
fiat object part
b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
an edge of a cube-shaped portion of space.
A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]
one-dimensional spatial region
A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]
a collection of cells in a blood biobank.
a swarm of bees is an aggregate of members who are linked together through natural bonds
a symphony orchestra
an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
defined by fiat: the aggregate of members of an organization
defined through physical attachment: the aggregate of atoms in a lump of granite
defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
defined via attributive delimitations such as: the patients in this hospital
the aggregate of bearings in a constant velocity axle joint
the aggregate of blood cells in your body
the nitrogen atoms in the atmosphere
the restaurants in Palo Alto
your collection of Meissen ceramic plates.
An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
(forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]
object aggregate
An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
(forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]
a cube-shaped region of space
a sphere-shaped region of space,
A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]
three-dimensional spatial region
A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]
Manhattan Canyon)
a hole in the interior of a portion of cheese
a rabbit hole
an air traffic control region defined in the airspace above an airport
the Grand Canyon
the Piazza San Marco
the cockpit of an aircraft
the hold of a ship
the interior of a kangaroo pouch
the interior of the trunk of your car
the interior of your bedroom
the interior of your office
the interior of your refrigerator
the lumen of your gut
your left nostril (a fiat part – the opening – of your left nasal cavity)
b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]
site
b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]
atom
cell
cells and organisms
engineered artifacts
grain of sand
molecule
organelle
organism
planet
solid portions of matter
star
BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
BFO 2 Reference: an object is a maximal causally unified material entity
BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
object
b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
generically dependent continuant
b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
the function of a hammer to drive in nails
the function of a heart pacemaker to regulate the beating of a heart through electricity
the function of amylase in saliva to break down starch into sugar
BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]
function
A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]
the boundary between the 2nd and 3rd year of your life.
p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
(forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
(iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]
process boundary
(forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
(iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]
p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
the temporal region during which a process occurs.
BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]
one-dimensional temporal region
A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]
a flame
a forest fire
a human being
a hurricane
a photon
a puff of smoke
a sea wave
a tornado
an aggregate of human beings.
an energy wave
an epidemic
the undetached arm of a human being
BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
material entity
A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions.
BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29
Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
Every continuant fiat boundary is located at some spatial region at every time at which it exists
(iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]
continuant fiat boundary
b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
(iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]
BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10
immaterial entity
The Equator
all geopolitical boundaries
all lines of latitude and longitude
the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin.
the median sulcus of your tongue
a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
(iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]
one-dimensional continuant fiat boundary
a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
(iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]
On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]
process profile
b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]
John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
a marriage bond, an instance of love, an obligation between one person and another.
b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
(iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]
relational quality
b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
(iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]
a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
(iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]
two-dimensional continuant fiat boundary
a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
(iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]
the geographic North Pole
the point of origin of some spatial coordinate system.
the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet
zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
(iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]
zero-dimensional continuant fiat boundary
zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
requested by Melanie Courtot
a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
(iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]
a temporal region that is occupied by a process boundary
right now
the moment at which a child is born
the moment at which a finger is detached in an industrial accident
the moment of death.
temporal instant.
A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
(forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]
zero-dimensional temporal region
A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
(forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]
A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Beilstein:7694998
CAS:137234-62-9
DrugBank:DB00582
Drug_Central:2846
LINCS:LSM-5244
PMID:12940129
PMID:22718362
PMID:23392902
PMID:23527908
PMID:23766489
PMID:24102553
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
voriconazole
(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
(alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
VCZ
Vfend
voriconazol
voriconazole
voriconazolum
CHEBI:10023
voriconazole
Beilstein:7694998
Beilstein
CAS:137234-62-9
ChemIDplus
CAS:137234-62-9
DrugBank
Drug_Central:2846
DrugCentral
PMID:12940129
Europe PMC
PMID:22718362
Europe PMC
PMID:23392902
Europe PMC
PMID:23527908
Europe PMC
PMID:23766489
Europe PMC
PMID:24102553
Europe PMC
A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Beilstein:3568352
CAS:85721-33-1
DrugBank:DB00537
Drug_Central:659
LINCS:LSM-5226
PMID:10397494
PMID:10737746
Reaxys:3568352
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Ciprofloxacin
ciprofloxacin
1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
ciprofloxacin
ciprofloxacine
ciprofloxacino
ciprofloxacinum
CHEBI:100241
ciprofloxacin
Beilstein:3568352
Beilstein
CAS:85721-33-1
ChemIDplus
Drug_Central:659
DrugCentral
PMID:10397494
ChEMBL
PMID:10737746
ChEMBL
Reaxys:3568352
Reaxys
Beilstein:3641829
CAS:107753-78-6
DrugBank:DB00549
Drug_Central:2855
LINCS:LSM-5792
PMID:11888331
PMID:19331987
PMID:22159431
PMID:22614107
PMID:24258705
PMID:25798389
PMID:25834030
Reaxys:3641829
cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
Accolate
cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate
zafirlukast
CHEBI:10100
zafirlukast
Beilstein:3641829
Beilstein
CAS:107753-78-6
ChemIDplus
Drug_Central:2855
DrugCentral
PMID:11888331
Europe PMC
PMID:19331987
Europe PMC
PMID:22159431
Europe PMC
PMID:22614107
Europe PMC
PMID:24258705
Europe PMC
PMID:25798389
Europe PMC
PMID:25834030
Europe PMC
Reaxys:3641829
Reaxys
A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
C10H13N5O4
Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Beilstein:763034
CAS:30516-87-1
DrugBank:DB00495
Drug_Central:2861
LINCS:LSM-5806
PMID:19112024
PMID:26859826
PMID:29438107
PMID:9203666
Wikipedia:Zidovudine
3'-azido-3'-deoxythymidine
AZT
AZT
Azidothymidine
Retrovir
Zidovudin
Zidovudinum
zidovudine
CHEBI:10110
zidovudine
Beilstein:763034
Beilstein
CAS:30516-87-1
ChemIDplus
CAS:30516-87-1
DrugBank
Drug_Central:2861
DrugCentral
PMID:19112024
ChEMBL
PMID:26859826
Europe PMC
PMID:29438107
Europe PMC
PMID:9203666
Europe PMC
A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
CAS:111406-87-2
DrugBank:DB00744
Drug_Central:2862
LINCS:LSM-5084
PMID:19309543
PMID:19645854
PMID:20204486
PMID:20436887
1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
Zileuton
(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
Leutrol
N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
Zyflo
zileuton
zileutonum
CHEBI:10112
zileuton
CAS:111406-87-2
ChemIDplus
Drug_Central:2862
DrugCentral
PMID:19309543
Europe PMC
PMID:19645854
Europe PMC
PMID:20204486
Europe PMC
PMID:20436887
Europe PMC
A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
Beilstein:3573079
CAS:42399-41-7
DrugBank:DB00343
Drug_Central:897
LINCS:LSM-2523
PMID:11937779
PMID:16651034
PMID:19167257
PMID:23687551
PMID:24261918
PMID:25122162
PMID:8369596
Reaxys:3573079
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
D-cis-diltiazem
d-cis-diltiazem
diltiazem
diltiazemum
CHEBI:101278
diltiazem
Beilstein:3573079
Beilstein
CAS:42399-41-7
ChemIDplus
CAS:42399-41-7
NIST Chemistry WebBook
Drug_Central:897
DrugCentral
PMID:11937779
Europe PMC
PMID:16651034
Europe PMC
PMID:19167257
Europe PMC
PMID:23687551
Europe PMC
PMID:24261918
Europe PMC
PMID:25122162
Europe PMC
PMID:8369596
Europe PMC
Reaxys:3573079
Reaxys
A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.
CAS:183321-74-6
DrugBank:DB00530
Drug_Central:1045
LINCS:LSM-1097
PMID:12270171
PMID:14684309
PMID:15711537
PMID:16014882
PMID:16014883
PMID:16480284
PMID:17889528
PMID:17983745
PMID:29448920
PMID:29579331
PMID:29687154
PMID:30039303
PMID:30071517
PMID:30150014
PMID:30158288
Reaxys:8798958
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine
erlotinib
erlotinibum
CHEBI:114785
erlotinib
CAS:183321-74-6
ChemIDplus
CAS:183321-74-6
DrugBank
Drug_Central:1045
DrugCentral
PMID:12270171
ChEMBL
PMID:14684309
ChEMBL
PMID:15711537
ChEMBL
PMID:16014882
Europe PMC
PMID:16014883
Europe PMC
PMID:16480284
ChEMBL
PMID:17889528
ChEMBL
PMID:17983745
ChEMBL
PMID:29448920
Europe PMC
PMID:29579331
Europe PMC
PMID:29687154
Europe PMC
PMID:30039303
Europe PMC
PMID:30071517
Europe PMC
PMID:30150014
Europe PMC
PMID:30158288
Europe PMC
Reaxys:8798958
Reaxys
An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Beilstein:484561
CAS:24526-64-5
DrugBank:DB04821
Drug_Central:1958
LINCS:LSM-4388
PMID:1502708
PMID:24766210
PMID:7189402
Reaxys:484561
2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
Nomifensine
(+-)-Nomifensin
(+-)-Nomifensine
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
D,L-nomifensine
Nomifenison
Nomifensin
Nomiphensine
R/S-nomifensine
nomifensina
nomifensine
nomifensinum
CHEBI:116225
nomifensine
Beilstein:484561
Beilstein
CAS:24526-64-5
ChemIDplus
CAS:24526-64-5
NIST Chemistry WebBook
Drug_Central:1958
DrugCentral
PMID:1502708
Europe PMC
PMID:24766210
Europe PMC
PMID:7189402
Europe PMC
Reaxys:484561
Reaxys
1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.
Beilstein:7387333
CAS:154598-52-4
DrugBank:DB00625
Drug_Central:989
LINCS:LSM-5526
PMID:10576692
PMID:10673109
PMID:25017682
Reaxys:7387333
(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
Efavirenz
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
CHEBI:119486
efavirenz
Beilstein:7387333
Beilstein
CAS:154598-52-4
ChemIDplus
Drug_Central:989
DrugCentral
PMID:10576692
ChEMBL
PMID:10673109
ChEMBL
PMID:25017682
Europe PMC
Reaxys:7387333
Reaxys
A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.
Beilstein:4318684
CAS:83015-26-3
DrugBank:DB00289
Drug_Central:256
LINCS:LSM-2452
PMID:15338851
PMID:23048018
Reaxys:4318684
(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
(-)-Tomoxetine
Tomoxetina
Tomoxetinum
atomoxetine
tomoxetine
CHEBI:127342
atomoxetine
Beilstein:4318684
Beilstein
CAS:83015-26-3
ChemIDplus
Drug_Central:256
DrugCentral
PMID:15338851
Europe PMC
PMID:23048018
Europe PMC
Reaxys:4318684
Reaxys
A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class.
MeSH:C032881
PMID:20118541
Lysophosphatidic acid (LPA) is a lipid mediator that is known to exhibit chemotactic activity toward a variety of cancer cells. However, its effect on the immune system has not been studied extensively. Another lipid mediator, sphingosine-1-phosphate (S1P), has been shown to influence lymphocyte recirculation by regulating lymphocyte egress from lymphoid organs. In this study, we found that LPA inhibits spontaneous migration of mouse splenic lymphocytes through a chemorepulsive effect. We also demonstrated that LPA inhibits chemokine CCL21-induced lymphocyte migration. This inhibitory effect on CCL21-induced migration was observed for both T and B cells. The involvement of a receptor, LPA(1), LPA(2) or LPA(3), in the inhibition of the CCL21-induced migration was confirmed with a synthetic agonist, oleyl thiophosphate. Considering that the signaling by CCL21 through cognate receptor CCR7 contributes to lymphocyte homing and dendritic cell trafficking to lymph nodes, LPA may play a role as a key regulator of these processes. The inhibitory effect of LPA is in remarkable contrast to the effect of S1P receptor signaling, which is known to potentiate lymphocyte chemotaxis involving CCR7.
PMID:7768880
Lysophosphatidic acid, a multifunctional phospholipid messenger.
Lysophosphatidic acid (LPA1(1); 1-acyl-glycerol-3-phosphate),is the simplest of all glycerophospholipids. While LPA has long been known as a precursor of phospholipid biosynthesis in both eukaryotic and prokaryotic cells, only recently has LPA emerged as an intercellular signaling molecule that is rapidly produced and released by activated cells, notably platelets, to influence target cells by acting on a specific cell-surface receptor.
The list of biological responses to LPA is quite diverse, ranging from induction of cell proliferation to stimulation of neurite retraction.
The mitogenic activities of LPA have been best studied in fibroblasts. As with peptide growth factors, induction of DNA synthesis by LPA requires its long term presence in the medium
LPA, but not peptide growth factors, can mimic serum in inducing invasion of carcinoma and hepatoma cells into monolayers of mesothelial cells. The underlying mechanism is not clear but may well involve both increased cell adhesion and enhanced cell motility.
Many mitogens activate the p85/p110 phosphatidylinositol (PI) 3-kinase in their target cells and so does LPA. LPA-induced PI 3-kinase activity has been found in 3T3 cells (Ref. 44; but see ref. 45 for conflicting data) and in megakaryoblastic cells. Whatever its precise link to the LPA receptor and physiological function, PI 3-kinase does not seem to be essential for mitogenic signaling, since microinjection of a neutralizing antibody does not affect LPA-induced DNA synthesis.
LPA
lysophosphatidic acid
A class of lipoproteins with a density between that of low-density and very-low-density lipoproteins. They are formed by the degradatiion of very-low-density lipoproteins.
IDL
intermediate-density lipoprotein
An agonist that binds to and activates farnesoid X receptors
Wikipedia:Farnesoid_X_receptor
BAR agonist
FXR agonist
bile acid receptor agonist
farnesoid X receptor agonist
A drug that makes increases the sensitivity of tumour cells to radiation therapy.
PMID:12520460
radiosensitiser
radiosensitisers
radiosensitising agent
radiosensitising agents
radiosensitizer
radiosensitizers
radiosensitizing agents
CHEBI:132992
radiosensitizing agent
PMID:12520460
Europe PMC
A role played by the entity which inhibits the oxidation of any fatty acid.
fatty acid oxidation inhibitor
Abbreviation for nicotinamide-adenine dinucleotide when its oxidation state is unknown or unspecified. It is used in metabolic pathways like glycolysis and citric acid cycle.
Wikipedia:Nicotinamide_adenine_dinucleotide
NAD
CAS:65-64-5
Drug_Central:4865
ICI-31397
actomol
mebanazine hydrochloride
mebanazine monohydrochloride
mebanazine monooxalate
mebanazine monosulfate
mebanazine oxalate
mebanazine sulfate
CHEBI:134728
mebanazine
CAS:65-64-5
DrugCentral
Drug_Central:4865
DrugCentral
CAS:4214-72-6
Drug_Central:1485
N-(Isopropylamino)-2-pyrimidine
CHEBI:134762
isaxonine
CAS:4214-72-6
DrugCentral
Drug_Central:1485
DrugCentral
CAS:547-44-4
Drug_Central:2496
sulfanilcarbamid
sulfanilylurea
sulfaurea
sulphacarbamide
sulphaurea
urosulfan
urosulfane
CHEBI:134891
sulfacarbamide
CAS:547-44-4
DrugCentral
Drug_Central:2496
DrugCentral
CAS:7175-09-9
Drug_Central:2662
5-Methyl-7-bromo-8-hydroxyquinoline
CHEBI:134965
tilbroquinol
CAS:7175-09-9
DrugCentral
Drug_Central:2662
DrugCentral
CAS:92623-85-3
Drug_Central:1808
(+/-)-Milnacipran
midalcipran
milnacipran HCl
milnacipran hydrochloride
CHEBI:135005
milnacipran
CAS:92623-85-3
DrugCentral
Drug_Central:1808
DrugCentral
CAS:21721-92-6
Drug_Central:1946
altimol
CHEBI:135009
nitrefazole
CAS:21721-92-6
DrugCentral
Drug_Central:1946
DrugCentral
Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID) that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis and pain. (by Wikipedia)
C13H14ClNO2
ClC1=C(C=CC(=C1)C(C(O)=O)C)N2CC=CC2
CAS:31793-07-4
DrugBank:DB13722
Drug_Central:2213
Wikipedia:Pirprofen
racemic pirprofen
rengasil
CHEBI:135028
pirprofen
CAS:31793-07-4
DrugCentral
Drug_Central:2213
DrugCentral
CAS:5310-55-4
Drug_Central:3717
clomacran phosphate
CHEBI:135273
clomacran
CAS:5310-55-4
DrugCentral
Drug_Central:3717
DrugCentral
CAS:56775-88-3
Drug_Central:2863
cis-Zimelidine
zimeldine hydrochloride hydrate
zimelidine
zimelidine HCl
zimelidine dihydrochloride
zimelidine dihydrochloride hydrate
zimelidine dihydrochloride monohydrate
zimelidine hydrochloride
CHEBI:135357
zimeldine
CAS:56775-88-3
DrugCentral
Drug_Central:2863
DrugCentral
CAS:125-13-3
Drug_Central:2038
oxyphenisatin
phenolisatin
veripaque
CHEBI:135358
oxyphenisatine
CAS:125-13-3
DrugCentral
Drug_Central:2038
DrugCentral
CAS:25803-14-9
Drug_Central:698
clometacine
clometazin
clomethacin
duperan
mindolic acid
CHEBI:135512
clometacin
CAS:25803-14-9
DrugCentral
Drug_Central:698
DrugCentral
CAS:84-04-8
Drug_Central:2180
mornidine
nausidol
nometine
CHEBI:135641
pipamazine
CAS:84-04-8
DrugCentral
Drug_Central:2180
DrugCentral
C21H23Cl2N3O
C(C(N(CCC)CCC)=O)C1=C(N=C2N1C=C(C=C2)Cl)C3=CC=C(C=C3)Cl
CAS:82626-01-5
Drug_Central:134
Wikipedia:Alpidem
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family, related to the more well known sleeping medication zolpidem. (by Wikipedia)
Ananxyl
ananxyl
CHEBI:135649
alpidem
CAS:82626-01-5
DrugCentral
Drug_Central:134
DrugCentral
CAS:145733-36-4
Drug_Central:3839
ANA-756
ANA756
verdia
CHEBI:135666
tasosartan
CAS:145733-36-4
DrugCentral
Drug_Central:3839
DrugCentral
CAS:84845-75-0
Drug_Central:4002
niperotidine HCl
niperotidine hydrochloride
perultid
piperonyl ranitidine HCl
piperonyl ranitidine hydrochloride
CHEBI:135706
niperotidine
CAS:84845-75-0
DrugCentral
Drug_Central:4002
DrugCentral
CAS:100981-43-9
Drug_Central:979
FI-3542
ebrodin
ulsanic
CHEBI:135774
ebrotidine
CAS:100981-43-9
DrugCentral
Drug_Central:979
DrugCentral
CAS:68-90-6
Drug_Central:321
cardivix
dilafurane
CHEBI:135814
benziodarone
CAS:68-90-6
DrugCentral
Drug_Central:321
DrugCentral
CAS:146961-76-4
Drug_Central:102
alatrofloxacin mesilate
alatrofloxacin mesylate
CHEBI:135829
alatrofloxacin
CAS:146961-76-4
DrugCentral
Drug_Central:102
DrugCentral
sn-glycero-3-phosphonocholine
glycerophosphonocholine
Any psychotropic drug that induces anxiety or panic.
Wikipedia:Anxiogenic
panicogenic
anxiogenic
Any pathway inhibitor that inhibits the Hedgehog signalling pathway.
Hedgehog pathway inhibitor
Hedgehog pathway inhibitors
Hedgehog signaling pathway inhibitors
CHEBI:140921
Hedgehog signaling pathway inhibitor
A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.
C3H6Cl2
CC(CCl)Cl
1,2-dichloropropane
A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.
4-hydroxynonenal
Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms.
CAS:220620-09-7
DrugBank:DB00560
Drug_Central:2661
PMID:17194827
PMID:17210772
PMID:17220399
PMID:17307973
PMID:17353238
PMID:17353249
Reaxys:8379453
(4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
CHEBI:149836
tigecycline
CAS:220620-09-7
ChemIDplus
Drug_Central:2661
DrugCentral
PMID:17194827
ChEMBL
PMID:17210772
ChEMBL
PMID:17220399
ChEMBL
PMID:17307973
ChEMBL
PMID:17353238
ChEMBL
PMID:17353249
ChEMBL
Reaxys:8379453
Reaxys
The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Wikipedia:Acetaldehyde
acetaldehyde
An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
CAS:56-65-5
DrugBank:DB00171
adenosine 5'-triphosphate
adenosine triphosphate
ATP
The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD(+) is involved in redox reactions, carrying electrons from one reaction to another.
NAD(+)
A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.
polynucleotide
CAS:86-01-1
DrugBank:DB04137
guanosine 5'-triphosphate
GTP
A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine.
DrugBank:DB04327
PtdEtn
phosphatidylethanolamine
A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3β-hydroxy group.
C27H46O
C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3(CC=C2C[C@H](C1)O)[H])(CC[C@@]4([C@H](C)CCCC(C)C)[H])[H])C)[H])C
Wikipedia:cholesterol
cholesterol
IMR:0001353
ISBN:0815340729
1-O-(3-sn-phosphatidyl)-1D-myo-inositol 3,4-bis(dihydrogen phosphate)
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
PtsIns(3,4)P2
PtsIns-3,4-P2
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ISBN:0815340729
ISBN:0815340729
A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
C2H6O
CCO
ethanol
A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.
C5H6O8PR3
phospholipid
A monohydroxy-5β-cholanic acid with aα-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
C24H40O3
[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@H](O)C2
lithocholic acid
A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond.
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
DrugBank:DB00640
Adenine riboside
Adenosine
Ribofuranosyladenine
adenosine
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
MeSH:D000241
A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
phosphatidic acid
A bile acid that is 5β-cholan-24-oic acid bearing threeα-hydroxy substituents at position 3, 7 and 12.
InChIKey:BHQCQFFYRZLCQQ-OELDTZBJSA-N
cholic acid
A sphing-4-enine in which the double bond is trans.
IMR:0100178
Sphingenine
Sphingoid
sphingosine
Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
LPS
Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants.
liposaccharide
Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants.
ISBN:0815340729
The 17beta-isomer of estradiol.
17β-Estradiol
NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
CHEBI:16474
Wikipedia:NADPH
2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
NADP-reduced
NADPH
A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
nitric oxide
A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
C2HCl3
ClC=C(Cl)Cl
CAS:79-01-6
Wikipedia:Trichloroethylene
1,1,2-trichloroethene
trichloroethylene
IMR:0001352
1-O-(3-sn-phosphatidyl)-1D-myo-inositol 3,4,5-tris(dihydrogen phosphate)
1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Phosphatidylinositol-3,4,5-trisphosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
PIP3
PtsIns(3,4,5)P3
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
carbohydrate
A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.
Beilstein:752696
CAS:54965-21-8
DrugBank:DB00518
Drug_Central:103
LINCS:LSM-3782
PMID:22152396
PMID:24403707
PMID:24411094
Pesticides:albendazole
Reaxys:752696
Albendazole
albendazole
methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate
(5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
5-(propylthio)-2-carbomethoxyaminobenzimidazole
Albenza
Eskazole
O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate
Proftril
Valbazen
Zentel
CHEBI:16664
albendazole
Beilstein:752696
Beilstein
CAS:54965-21-8
ChemIDplus
Drug_Central:103
DrugCentral
PMID:22152396
Europe PMC
PMID:24403707
Europe PMC
PMID:24411094
Europe PMC
Pesticides:albendazole
Alan Wood's Pesticides
Reaxys:752696
Reaxys
Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
peptide
A phosphatidylinositol in which the inositol moiety is the 1D-myo isomer and the phosphatidyl group is located at its position 1.
C11H17O13P
[C@@H]1([C@@H]([C@@H]([C@@H]([C@H]([C@@H]1O)O)O)O)OP(OC[C@@H](COC(*)=O)OC(=O)*)(=O)O)O
PMID:28600633
1-O-(3-sn-phosphatidyl)-1D-myo-inositol
1-phosphatidyl-1D-myo-inositol
A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
guanosine
A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
A dihydroxy-5β-cholanic acid that is (5β)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
InChIKey:RUDATBOHQWOJDD-BSWAIDMHSA-N
Beilstein:3219887
CAS:474-25-9
DrugBank:DB06777
Drug_Central:4361
LINCS:LSM-5353
LIPID_MAPS_instance:LMST04010032
PMID:11530998
PMID:16037564
PMID:24448653
PMID:24464484
Reaxys:3219887
3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
Chenodeoxycholic acid
3alpha,7alpha-Dihydroxy-5beta-cholanic acid
7alpha-hydroxylithocholic acid
CDCA
Chenix
Chenodiol
anthropodeoxycholic acid
anthropodesoxycholic acid
chenic acid
gallodesoxycholic acid
CHEBI:16755
chenodeoxycholic acid
Beilstein:3219887
Beilstein
CAS:474-25-9
ChemIDplus
Drug_Central:4361
DrugCentral
LIPID_MAPS_instance:LMST04010032
LIPID MAPS
PMID:11530998
Europe PMC
PMID:16037564
Europe PMC
PMID:24448653
Europe PMC
PMID:24464484
Europe PMC
Reaxys:3219887
Reaxys
A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
CAS:20398-34-9
Adenosine 5'-monophosphate
AMP
A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
C10H17N3O6S
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
DrugBank:DB00143
Wikipedia:Glutathione
Glutathione
5-L-Glutamyl-L-cysteinylglycine
GSH
Reduced glutathione
L-gamma-glutamyl-L-cysteinylglycine
A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.
DrugBank:DB00157
Wikipedia:Nicotinamide_adenine_dinucleotide
NADH
A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.
C7H6O3
OC(=O)c1ccccc1O
CAS:69-72-7
DrugBank:DB00936
Wikipedia:Salicylic_acid
2-hydroxybenzoic acid
salicylic acid
Derivatives of phosphoglycerols which have only one of the alcohol groups of the glycerol backbone ester-linked with a fatty acid.
lysophospholipids
monoacylglycerol phosphates
monoacylglycerophosphate
monoacylglycerophosphates
Lysophospholipid
monoacylglycerol phosphate
A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
C33H36N4O6
CC1=C(C=C)\C(NC1=O)=C\c1[nH]c(Cc2[nH]c(\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC(O)=O)c(CCC(O)=O)c1C
Wikipedia:Bilirubin
bilirubin
High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.
DNA
deoxyribonucleic acid
An aldohexose used as a source of energy and metabolic intermediate.
glucose
An estrogen that has formula C18H22O2.
ATC:G03CA07
ATC:G03CC04
CASRN:53-16-7
DrugBank:DB00655
InChIKey:DNXHEGUUPJUMQT-CBZIJGRNSA-N
estrone
An inositol having myo- configuration.
Wikipedia:Inositol
myo-inositol
An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Beilstein:1915399
Beilstein:3653705
CAS:58-22-0
DrugBank:DB00624
Drug_Central:2607
Gmelin:538843
LIPID_MAPS_instance:LMST02020002
PMID:10438974
PMID:11786693
PMID:18900503
PMID:24498482
Reaxys:1915399
17beta-hydroxyandrost-4-en-3-one
TESTOSTERONE
Testosterone
testosterone
17beta-Hydroxy-4-androsten-3-one
17beta-hydroxy-4-androsten-3-one
4-androsten-17beta-ol-3-one
Androderm
Testosteron
testosterona
testosterone
testosteronum
CHEBI:17347
testosterone
Beilstein:1915399
Beilstein
Beilstein:3653705
Beilstein
CAS:58-22-0
ChemIDplus
CAS:58-22-0
NIST Chemistry WebBook
Drug_Central:2607
DrugCentral
Gmelin:538843
Gmelin
LIPID_MAPS_instance:LMST02020002
LIPID MAPS
PMID:10438974
Europe PMC
PMID:11786693
Europe PMC
PMID:18900503
Europe PMC
PMID:24498482
Europe PMC
Reaxys:1915399
Reaxys
The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
C15H13NO
C(=O)(NC=1C=C2C(C=3C(C2)=CC=CC3)=CC1)C
CAS:53-96-3
Wikipedia:2-Acetylaminofluorene
N-(9H-fluoren-2-yl)acetamide
2-AAF
2-Acetylaminofluorene
2-acetamidofluorene
A cytidine 5'-phosphate that has formula C9H14N3O8P.
CMP
A compound RC(2O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
aldehyde
A glycerophosphoglycerol that is glycerol in which the hydrogen of one of the primary hydroxy groups has been replaced by a phosphatidyl group.
phosphatidylglycerol
A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Beilstein:5382060
CAS:95058-81-4
DrugBank:DB00441
Drug_Central:1283
LINCS:LSM-5333
PMID:11034044
PMID:11061612
PMID:11088063
PMID:11122828
PMID:11132538
PMID:11142482
PMID:11221019
PMID:11356111
PMID:11374818
PMID:11489002
PMID:11504793
PMID:11510027
PMID:11585734
PMID:11595724
PMID:11807603
PMID:11859947
PMID:11901308
PMID:12057041
PMID:12057046
PMID:12057157
PMID:12115355
PMID:12142097
PMID:12520460
PMID:12571808
PMID:12722678
PMID:12722691
PMID:12743987
PMID:12761494
PMID:12798170
PMID:12917815
PMID:12954073
PMID:14606642
PMID:14653877
PMID:14720338
PMID:15131028
PMID:15160243
PMID:15221904
PMID:15282439
PMID:15297392
PMID:15542781
PMID:15637766
PMID:15744590
PMID:16001951
PMID:16041610
PMID:16080557
PMID:16143373
PMID:16149285
PMID:16317298
PMID:16500746
PMID:16555971
PMID:16584929
PMID:16807461
PMID:16807463
PMID:16894289
PMID:16905983
PMID:17101674
PMID:17296311
PMID:17296587
PMID:17347561
PMID:17429628
PMID:17460420
PMID:17602464
PMID:17639396
PMID:17887663
PMID:17939651
PMID:17941128
PMID:17987263
PMID:18035967
PMID:18050344
PMID:18086345
PMID:18166944
PMID:18186604
PMID:18257544
PMID:18348652
PMID:18773046
PMID:18789834
PMID:18819792
PMID:18981552
PMID:19034448
PMID:19177022
PMID:19399788
PMID:19839926
PMID:19879060
PMID:22763439
PMID:28594276
PMID:28608357
PMID:28912244
Reaxys:5382060
2'-deoxy-2',2'-difluorocytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-2',2'-difluorocytidine
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
gemcitabina
gemcitabine
gemcitabinum
CHEBI:175901
gemcitabine
Beilstein:5382060
Beilstein
CAS:95058-81-4
ChemIDplus
CAS:95058-81-4
DrugBank
Drug_Central:1283
DrugCentral
PMID:11034044
Europe PMC
PMID:11061612
Europe PMC
PMID:11088063
Europe PMC
PMID:11122828
Europe PMC
PMID:11132538
Europe PMC
PMID:11142482
Europe PMC
PMID:11221019
Europe PMC
PMID:11356111
ChEMBL
PMID:11374818
Europe PMC
PMID:11489002
Europe PMC
PMID:11504793
Europe PMC
PMID:11510027
Europe PMC
PMID:11585734
Europe PMC
PMID:11595724
Europe PMC
PMID:11807603
Europe PMC
PMID:11859947
Europe PMC
PMID:11901308
Europe PMC
PMID:12057041
Europe PMC
PMID:12057046
Europe PMC
PMID:12057157
Europe PMC
PMID:12115355
Europe PMC
PMID:12142097
Europe PMC
PMID:12520460
Europe PMC
PMID:12571808
Europe PMC
PMID:12722678
Europe PMC
PMID:12722691
Europe PMC
PMID:12743987
Europe PMC
PMID:12761494
Europe PMC
PMID:12798170
Europe PMC
PMID:12917815
Europe PMC
PMID:12954073
Europe PMC
PMID:14606642
Europe PMC
PMID:14653877
Europe PMC
PMID:14720338
Europe PMC
PMID:15131028
Europe PMC
PMID:15160243
Europe PMC
PMID:15221904
Europe PMC
PMID:15282439
Europe PMC
PMID:15297392
Europe PMC
PMID:15542781
Europe PMC
PMID:15637766
Europe PMC
PMID:15744590
Europe PMC
PMID:16001951
Europe PMC
PMID:16041610
Europe PMC
PMID:16080557
Europe PMC
PMID:16143373
Europe PMC
PMID:16149285
Europe PMC
PMID:16317298
Europe PMC
PMID:16500746
Europe PMC
PMID:16555971
Europe PMC
PMID:16584929
Europe PMC
PMID:16807461
Europe PMC
PMID:16807463
Europe PMC
PMID:16894289
Europe PMC
PMID:16905983
Europe PMC
PMID:17101674
ChEMBL
PMID:17296311
Europe PMC
PMID:17296587
Europe PMC
PMID:17347561
Europe PMC
PMID:17429628
Europe PMC
PMID:17460420
Europe PMC
PMID:17602464
ChEMBL
PMID:17639396
Europe PMC
PMID:17887663
ChEMBL
PMID:17939651
ChEMBL
PMID:17941128
Europe PMC
PMID:17987263
Europe PMC
PMID:18035967
Europe PMC
PMID:18050344
Europe PMC
PMID:18086345
Europe PMC
PMID:18166944
Europe PMC
PMID:18186604
ChEMBL
PMID:18257544
ChEMBL
PMID:18348652
Europe PMC
PMID:18773046
Europe PMC
PMID:18789834
Europe PMC
PMID:18819792
Europe PMC
PMID:18981552
Europe PMC
PMID:19034448
Europe PMC
PMID:19177022
Europe PMC
PMID:19399788
Europe PMC
PMID:19839926
Europe PMC
PMID:19879060
Europe PMC
PMID:22763439
Europe PMC
PMID:28594276
Europe PMC
PMID:28608357
Europe PMC
PMID:28912244
Europe PMC
Reaxys:5382060
Reaxys
cytidine 5'-(tetrahydrogen triphosphate)
CTP
cytidine 5'-(tetrahydrogen triphosphate)
IUPAC
A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
C24H38O4
CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC
CAS:117-81-7
DEHP
Diethylhexylphthalate
bis(2-ethylhexyl) phthalate
Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.
IMR:0100177
Cer
N-acylated sphingoid
ceramide
Gentamicin is a parenterally administered, broad spectrum aminoglycoside antibiotic typically used for moderate to severe gram negative infections. Despite its wide use, gentamicin has not been definitively linked to instances of clinically apparent liver injury.
CAS:1403-66-3
DrugBank:DB00798
MeSH:D005839
Open TG-Gates compound_id=00147
https://livertox.nlm.nih.gov//Gentamicin.htm
https://pubchem.ncbi.nlm.nih.gov/compound/3467
gentamicin
Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.
C6H5O6R3
[*]C(=O)OCC(COC([*])=O)OC([*])=O
PMID:2474544
Triacylglycerol
triglyceride
C20H32N6O12S2
N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
CAS:27025-41-8
DrugBank:DB03310
GSSG
Oxidized glutathione
Oxiglutatione
Glutathione disulfide
An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.
C8H8O
C1OC1c1ccccc1
CAS:96-09-3
Wikipedia:Styrene_oxide
2-phenyloxirane
styrene-7,8-oxide
styrene oxide
C15H13NO2
CC(=O)N(O)c1ccc-2c(Cc3ccccc-23)c1
CAS:53-95-2
N-(9H-fluoren-2-yl)-N-hydroxyacetamide
N-OH-AAF
N-hydroxy-2-acetylaminofluorene
N-hydroxy-2-acetamidofluorene
A thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.
C22H35N7O17P3SR
CAS:9029-97-4
PMID:11264983
PMID:11524729
Acyl coenzyme A
Acyl-CoA
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCSC([*])=O
acyl-CoA
'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent.
lipid
Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent.
ISBN:0815340729
A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
Polysaccharide
polysaccharides
polysaccharide
Any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol.
phosphoinositide
An iron group element atom that has atomic number 26.
Fe
[Fe]
CAS:7439-89-6
DrugBank:DB01592
iron
iron atom
A class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.
DrugBank:DB00144
Ptd-L-Ser
phosphatidylserine
phosphatidyl-L-serine
The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.
CAS:3483-12-3
DrugBank:DB04447
LINCS:LSM-36870
1,4-dithiothreitol
IMR:0200477
IMR:0001350
PI(4,5)P2
PIP2
Phosphatidylinositol-4,5-bisphosphate
PtsIns-4,5-P2
PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol.
ISBN:0815340729
O2
[O][O-]
dioxidanidyl
superoxide
A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase.
ATP synthase inhibitor (mitochondrial respiratory-chain inhibitor)
Any of a group of related and highly toxic secondary metabolites (mycotoxins) whose main structural feature is a fused coumarin-bis(dihydrofuran) ring system and which are produced by strains of the moulds Aspergillus flavus or A. parasiticus, together with further metabolites of these mycotoxins.
aflatoxin
alkali metal atom
Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
CHEBI:22333
alkylating agent
A monoatomic or polyatomic species having one or more elementary charges of the electron.
anion
A role that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antioxidants
antioxydant
antoxidant
CHEBI:22586
antioxidant
A substance that destroys or inhibits replication of viruses.
anti-viral agent
anti-viral agents
antiviral
antiviral agents
antivirals
CHEBI:22587
antiviral agent
Members of the class of pyrimidones consisting of pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) and its derivatives. Largest group of the synthetic sedative/hypnotics, sharing a characteristic six-membered ring structure.
barbiturates
A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).
base
CAS:7440-70-2
DrugBank:DB01373
calcium
Ca
calcium atom
An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule.
EC 4.2.1.1 (carbonic anhydrase) inhibitors
EC 4.2.1.1 inhibitor
EC 4.2.1.1 inhibitors
anhydrase inhibitor
anhydrase inhibitors
carbonate anhydrase inhibitor
carbonate anhydrase inhibitors
carbonate dehydratase inhibitor
carbonate dehydratase inhibitors
carbonate hydro-lyase (carbon-dioxide-forming) inhibitor
carbonate hydro-lyase (carbon-dioxide-forming) inhibitors
carbonate hydro-lyase inhibitor
carbonate hydro-lyase inhibitors
carbonic acid anhydrase inhibitor
carbonic acid anhydrase inhibitors
carbonic anhydrase (EC 4.2.1.1) inhibitor
carbonic anhydrase (EC 4.2.1.1) inhibitors
carbonic anhydrase A inhibitor
carbonic anhydrase A inhibitors
carbonic anhydrase inhibitor
carbonic anhydrase inhibitors
carboxyanhydrase inhibitor
carboxyanhydrase inhibitors
CHEBI:23018
EC 4.2.1.1 (carbonic anhydrase) inhibitor
A substance intended to sterilize any organism.
chemosterilants
CHEBI:23092
chemosterilant
A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.
coenzyme
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
Wikipedia:Cofactor_(biochemistry)
cofactor
Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
molecular entity
C12H11N3
C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N
CAS:60-09-3
Wikipedia:Aniline_Yellow
4-Aminoazobenzene
4-[(E)-phenyldiazenyl]aniline
4-phenyldiazenylaniline
AAB
4-(phenylazo)aniline
A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.
CAS:56180-94-0
DrugBank:DB00284
Drug_Central:39
LINCS:LSM-4345
PMID:11937512
PMID:18248270
PMID:25044702
PMID:8893066
PMID:9805641
4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
Acarbose
Glucobay
Precose
acarbosa
acarbose
acarbosum
CHEBI:2376
acarbose
CAS:56180-94-0
ChemIDplus
Drug_Central:39
DrugCentral
PMID:11937512
Europe PMC
PMID:18248270
Europe PMC
PMID:25044702
Europe PMC
PMID:8893066
Europe PMC
PMID:9805641
Europe PMC
Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
Intended use of the molecular entity or part thereof by humans.
drugs
medicine
CHEBI:23888
drug
Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).
IMR:0001381
eicosanoid
icosanoid
A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
enzyme inhibitor
enzyme inhibitors
inhibidor enzimatico
inhibidores enzimaticos
inhibiteur enzymatique
inhibiteurs enzymatiques
CHEBI:23924
enzyme inhibitor
A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.
InChIKey=VOXZDWNPVJITMN-WKUFJEKOSA-N
Wikipedia:Estradiol
estradiol
A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
C3H7N3O2
CCN(N=O)C(N)=O
CAS:759-73-9
Wikipedia:ENU
1-ethyl-1-nitrosourea
N-ethyl-N-nitrosourea
Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure.
Beilstein:8335547
CAS:91714-94-2
DrugBank:DB00963
Drug_Central:401
LINCS:LSM-5585
[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
2-amino-3-(4-bromobenzoyl)benzeneacetic acid
[2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
bromfenac
bromfenaco
bromfenacum
CHEBI:240107
bromfenac
Beilstein:8335547
Beilstein
CAS:91714-94-2
ChemIDplus
Drug_Central:401
DrugCentral
A substance used to destroy fungal pests.
fungicides
CHEBI:24127
fungicide
gamma-GC
gamma-glutamylcysteine
glycerophosphoglycerols
A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
http://purl.obolibrary.org/obo/IMR_0000947
chemical compound
chemical entity
A role played by the molecular entity or part thereof within a biological context.
biological function
CHEBI:24432
biological role
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
GO:0005180
endocrine
hormones
CHEBI:24621
substance with hormone role:
http://purl.bioontology.org/ontology/STY/T125
hormone
Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.
proton
Compounds having the structure RN=CR2 (R = H, hydrocarbyl). Thus analogues of aldehydes or ketones, having NR doubly bonded to carbon; aldimines have the structure RCH=NR, ketimines have the structure R'2C=NR (where R' is not H). Imines include azomethines and Schiff bases. Imine is used as a suffix in systematic nomenclature to denote the C=NH group excluding the carbon atom.
CHEBI:24783
http://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=200906016906308703
http://purl.jp/bio/4/id/200906016906308703
imine
inositol
Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.
insecticides
CHEBI:24852
insecticide
A molecular entity having a net electric charge.
ion
An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
C17H12O6
[H][C@]12OC=C[C@@]1([H])c1c(O2)cc(OC)c2c3CCC(=O)c3c(=O)oc12
CAS:1162-65-8
(6aR,9aS)-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione
aflatoxin B1
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
metabolite
metabolites
primary metabolites
secondary metabolites
CHEBI:25212
metabolite
A role played by the entity that inhibits the mitochondrial respiratory-chain.
mitochondrial electron transport chain inhibitors
mitochondrial respiratory-chain inhibitor
Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
molecule
An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
Wikipedia:Mutagen
mutagene
mutagenes
mutagenic agent
mutageno
mutagenos
mutagens
CHEBI:25435
mutagen
Poisonous substance produced by fungi.
mycotoxin
A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
C20H16
Cc1c2ccccc2c(C)c2c1ccc1ccccc21
CAS:57-97-6
7,12-dimethylbenz(a)anthracene
7,12-dimethylbenzo[a]anthracene
7,12-dimethyltetraphene
A substance used to destroy pests of the phylum Nematoda (roundworms).
nematicides
nematocide
nematocides
CHEBI:25491
nematicide
An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
IMR:0000967 (obsolete)
neurotransmitter
N
nitrogen atom
An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.
organophosphorus compound
Inchikey:QVGXLLKOCUKJST-UHFFFAOYSA-N
oxygen
oxygen atom
oxygen molecular entity
HO2
[H]O[O]
(HO2)(.)
hydroperoxyl
Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.
pesticide
Pestizid
Pestizide
pesticides
CHEBI:25944
pesticide
CAS:7440-09-7
DrugBank:DB01345
potassium
potassium atom
The family of natural prostaglandins and prostaglandin-like compounds.
prostanoid
A molecular entity possessing an unpaired electron.
free radical
radical
Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Wikipedia:Reactive_oxygen_species
reactive oxygen species
Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess.
saturated fatty acid
A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
C25H29I2NO3
CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
Beilstein:1271711
CAS:1951-25-3
ChemicalBook:CB5310616
DrugBank:DB01118
Drug_Central:176
LINCS:LSM-2379
Open TG-Gates compound_id=00033
PMID:10188629
PMID:16479044
PMID:18368867
(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
Amiodarone
2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran
2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone
2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
amiodarona
amiodaronum
CHEBI:2663
amiodarone
Beilstein:1271711
Beilstein
CAS:1951-25-3
ChemIDplus
ChemicalBook:CB5310616
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5310616
Drug_Central:176
DrugCentral
PMID:10188629
Europe PMC
PMID:16479044
Europe PMC
PMID:18368867
Europe PMC
An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
C20H23N
CN(C)CCC=C1c2ccccc2CCc2ccccc12
CAS:50-48-6
DrugBank:DB00321
LINCS:LSM-3190
MeSH:D000639
Patent:WO2011089289
Wikipedia:Amitriptyline
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
amitriptyline
sodium atom
Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
sphingolipid
CAS:7704-34-9
sulfur
sulfur atom
A class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.
IMR:0100020
TX
thromboxane
Poisonous substance produced by a biological organism such as a microbe, animal or plant.
Wikipedia:Toxin
toxin
A chemical compound containing three hydroxy groups.
triol
An oxopurine that is the final oxidation product of purine metabolism.
uric acid
A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
CCl4
ClC(Cl)(Cl)Cl
CAS:56-23-5
LINCS:LSM-37019
Wikipedia:Carbon_Tetrachloride
CCl4
Carbon tetrachloride
tetrachloromethane
CAS:7440-44-0
Inchikey:OKTJSMMVPCPJKN-UHFFFAOYSA-N
carbon
carbon atom
Beilstein:212994
CAS:59-66-5
DrugBank:DB00819
Drug_Central:56
Gmelin:365421
LINCS:LSM-5543
Acetazolamide
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
5-acetylamino-1,3,4-thiadiazole-2-sulfonamide
Defiltran
Diacarb
Diamox
Diluran
Glaupax
N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
acetazolamida
acetazolamide
acetazolamidum
CHEBI:27690
acetazolamide
Beilstein:212994
Beilstein
CAS:59-66-5
ChemIDplus
CAS:59-66-5
NIST Chemistry WebBook
Drug_Central:56
DrugCentral
Gmelin:365421
Gmelin
An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.
Beilstein:95226
CAS:126-07-8
DrugBank:DB00400
Drug_Central:1331
LINCS:LSM-5259
LIPID_MAPS_instance:LMPK13060001
PMID:14407521
PMID:15078340
PMID:16922553
PMID:23111828
PMID:25476923
PMID:3277037
Reaxys:95226
(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
Griseofulvin
(+)-griseofulvin
Curling factor
Fulcin
Fulvicin
Grifulvin
Grisactin
Grisovin
Grysio
Lamoryl
Likuden
Poncyl
Spirofulvin
Sporostatin
amudane
griseofulvin
griseofulvina
griseofulvine
griseofulvinum
CHEBI:27779
griseofulvin
Beilstein:95226
Beilstein
CAS:126-07-8
ChemIDplus
CAS:126-07-8
NIST Chemistry WebBook
Drug_Central:1331
DrugCentral
LIPID_MAPS_instance:LMPK13060001
LIPID MAPS
PMID:14407521
Europe PMC
PMID:15078340
Europe PMC
PMID:16922553
Europe PMC
PMID:23111828
Europe PMC
PMID:25476923
Europe PMC
PMID:3277037
Europe PMC
Reaxys:95226
Reaxys
A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
C14H12O3
[H]C(=C([H])c1cc(O)cc(O)c1)c1ccc(O)cc1
CAS:501-36-0
DrugBank:DB02709
LINCS:LSM-2557
5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
resveratrol
A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
C22H24N2O8
[H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
CAS:60-54-8
DrugBank:DB00759
Wikipedia:Tetracycline
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
tetracycline
A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N1CCN(C)CC1)c(O)c4c3C2=O
CASRN:13292-46-1
DrugBank:DB01045
Wikipedia:Rifampicin
rifampicin
A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.
CAS:9005-79-2
glycogen
A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
CAS:58-74-2
DrugBank:DB01113
Drug_Central:2056
LINCS:LSM-2338
PMID:11971205
PMID:24414229
Reaxys:312930
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
CHEBI:28241
papaverine
CAS:58-74-2
ChemIDplus
CAS:58-74-2
NIST Chemistry WebBook
Drug_Central:2056
DrugCentral
PMID:11971205
Europe PMC
PMID:24414229
Europe PMC
Reaxys:312930
Reaxys
A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
C17H11NO7
COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O
CAS:313-67-7
8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
aristolochic acid
A phosphatidylglycerol composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol.
Wikipedia:cardiolipin
cardiolipin
A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.
C2H3Cl
ClC=C
CAS:75-01-4
Wikipedia:Chloroethene
Vinyl chloride
クロロエチレン
塩化ビニル
chloroethene
A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.
Beilstein:89175
CAS:147-94-4
DrugBank:DB00987
Drug_Central:770
LINCS:LSM-5470
PMID:15492802
Reaxys:89175
4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
Cytarabine
1-beta-D-Arabinofuranosylcytosine
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
Arabinoside C
Cytosine arabinoside
Cytosine-1-beta-D-arabinofuranoside
ara-C
arabinocytosine
citarabina
cytarabine
cytarabinum
cytosine-beta-D-arabinofuranoside
CHEBI:28680
cytarabine
Beilstein:89175
Beilstein
CAS:147-94-4
ChemIDplus
Drug_Central:770
DrugCentral
PMID:15492802
Europe PMC
Reaxys:89175
Reaxys
A ketohexose that is an isomer of glucose.
fructose
Any member of the phosphoinositide family of compounds, of which seven occur naturally.
phosphatidylinositol phosphate
A chromenone having the keto group located at the 2-position.
C=1C=CC=C2C1C=CC(=O)O2
DrugBank:DB04665
PMID:28166217
Wikipedia:Coumarin
coumarin
A bile acid that is 5β-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
InChIKey:KXGVEGMKQFWNSR-LLQZFEROSA-N
deoxycholic acid
Any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
IMR:0001651
PI
phosphatidylinositol
C14H8O3
Oc1cccc2C(=O)c3ccccc3C(=O)c12
CAS:129-43-1
1-hydroxyanthracene-9,10-dione
1-hydroxyanthraquinone
A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Beilstein:1791786
CAS:55-98-1
DrugBank:DB01008
Drug_Central:438
LINCS:LSM-5388
PMID:10523796
PMID:19361744
PMID:19611402
Reaxys:1791786
Busulfan
butane-1,4-diyl dimethanesulfonate
1,4-Bis(methanesulfonoxy)butane
1,4-Butanediol dimethanesulfonate
1,4-Dimesyloxybutane
1,4-Dimethanesulfonoxybutane
Bisulfex
Leucosulfan
Mablin
Mielucin
Misulban
Mitostan
Myeloleukon
Myleran
Tetramethylene bis(methanesulfonate)
busulfan
busulfano
busulfanum
CHEBI:28901
busulfan
Beilstein:1791786
Beilstein
CAS:55-98-1
ChemIDplus
Drug_Central:438
DrugCentral
PMID:10523796
Europe PMC
PMID:19361744
Europe PMC
PMID:19611402
Europe PMC
Reaxys:1791786
Reaxys
A ketoimine that has formula C8H7NO2.
CHEBI:29132
http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-76397
N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide
InChI=1S/C8H7NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3
NAPQI
N-acetyl-1,4-benzoquinone imine
N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide
IUPAC NAME
HO
[O][H]
hydroxyl
A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
CAS:446-86-6
DrugBank:DB00993
Drug_Central:269
PMID:11064448
PMID:15199672
PMID:15476481
PMID:15628319
PMID:15973722
PMID:16344342
PMID:16397313
PMID:16764353
PMID:16954801
PMID:17381669
PMID:17970886
PMID:18008354
PMID:18336531
PMID:19243907
PMID:20080917
PMID:25248004
PMID:25314066
PMID:25440430
PMID:25443086
PMID:25581826
PMID:25641386
PMID:28166217
PMID:8738760
PMID:9273463
PMID:9345422
Reaxys:1225351
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
Imuran (TN)
CHEBI:2948
azathioprine
CAS:446-86-6
ChemIDplus
Drug_Central:269
DrugCentral
PMID:11064448
Europe PMC
PMID:15199672
Europe PMC
PMID:15476481
Europe PMC
PMID:15628319
Europe PMC
PMID:15973722
Europe PMC
PMID:16344342
Europe PMC
PMID:16397313
Europe PMC
PMID:16764353
Europe PMC
PMID:16954801
Europe PMC
PMID:17381669
Europe PMC
PMID:17970886
Europe PMC
PMID:18008354
Europe PMC
PMID:18336531
Europe PMC
PMID:19243907
Europe PMC
PMID:20080917
Europe PMC
PMID:25248004
Europe PMC
PMID:25314066
Europe PMC
PMID:25440430
Europe PMC
PMID:25443086
Europe PMC
PMID:25581826
Europe PMC
PMID:25641386
Europe PMC
PMID:28166217
Europe PMC
PMID:8738760
Europe PMC
PMID:9273463
Europe PMC
PMID:9345422
Europe PMC
Reaxys:1225351
Reaxys
CAS:191114-48-4
Drug_Central:2581
TELITHROMYCIN
Telithromycin
(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside
HMR 3647
HMR-3647
HMR3647
RU 66647
RU-66647
RU66647
CHEBI:29688
telithromycin
Drug_Central:2581
DrugCentral
A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
CAS:11089-65-9
Open TG-Gates compound_id:00A02
Wikipedia:Tunicamycin
tunicamycin
1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Beilstein:273668
CAS:3562-84-3
Drug_Central:318
LINCS:LSM-2239
PMID:18636784
PMID:26693855
PMID:26792818
PMID:27391386
PMID:28131653
PMID:28166217
PMID:28202260
PMID:7661033
(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone
Benzbromarone
2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran
3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone
Uroleap (TN)
CHEBI:3023
benzbromarone
Beilstein:273668
Beilstein
CAS:3562-84-3
ChemIDplus
Drug_Central:318
DrugCentral
PMID:18636784
Europe PMC
PMID:26693855
Europe PMC
PMID:26792818
Europe PMC
PMID:27391386
Europe PMC
PMID:28131653
Europe PMC
PMID:28166217
Europe PMC
PMID:28202260
Europe PMC
PMID:7661033
Europe PMC
C17H12O7
[H][C@@]12Oc3cc(OC)c4c5CCC(=O)c5c(=O)oc4c3[C@]1([H])[C@@]1([H])O[C@@]1([H])O2
CAS:42583-46-0
6aS,7aS,8aR,8bR)-4-methoxy-2,3,6a,7a,8a,8b-hexahydrocyclopenta[c]oxireno[4',5']furo[3',2':4,5]furo[2,3-h]chromene-1,10-dione
aflatoxin B1 exo-8,9-epoxide
CCl3
Cl[C](Cl)Cl
trichloromethyl(.)
A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
HOR
O[*]
alcohol
A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Beilstein:5364666
CAS:90357-06-5
DrugBank:DB01128
Drug_Central:367
LINCS:LSM-1437
PMID:11915584
PMID:12015321
PMID:12017896
PMID:12421104
PMID:12959312
PMID:15509184
PMID:17313204
PMID:18062751
PMID:19194583
PMID:23527766
PMID:30784326
PMID:31099426
Reaxys:5364666
rac-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
(+-)-bicalutamide
(RS)-4'-cyano-alpha',alpha',alpha',-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide
(RS)-bicalutamide
Bicadex
Bical
Bicalox
Bicamide
Bicatlon
Bicusan
Binabic
Bypro
Calumid
Calutide
Calutol
Casodex
Cosudex
ICI 176,334
ICI 176334
ICI-176334
Kalumid
Ormandyl
bicalutamida
bicalutamide
bicalutamidum
racemic bicalutamide
CHEBI:3090
bicalutamide
Beilstein:5364666
Beilstein
CAS:90357-06-5
ChemIDplus
CAS:90357-06-5
NIST Chemistry WebBook
Drug_Central:367
DrugCentral
PMID:11915584
Europe PMC
PMID:12015321
Europe PMC
PMID:12017896
Europe PMC
PMID:12421104
Europe PMC
PMID:12959312
Europe PMC
PMID:15509184
Europe PMC
PMID:17313204
Europe PMC
PMID:18062751
Europe PMC
PMID:19194583
Europe PMC
PMID:23527766
Europe PMC
PMID:30784326
Europe PMC
PMID:31099426
Europe PMC
Reaxys:5364666
Reaxys
A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
C2HCl3O2
OC(=O)C(Cl)(Cl)Cl
CAS:76-03-9
trichloroacetic acid
An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
CAS:22131-79-9
Drug_Central:107
PMID:18796
PMID:19205
PMID:21068
PMID:236805
PMID:237493
PMID:241593
PMID:241595
PMID:241596
PMID:241597
PMID:241598
PMID:241600
PMID:241601
PMID:241602
PMID:241603
PMID:24426
PMID:4279126
PMID:509935
PMID:6103793
PMID:6106453
PMID:6109575
PMID:6120697
PMID:6141199
PMID:7853459
PMID:7905004
Reaxys:2116510
[3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
(4-Allyloxy-3-chlorphenyl)essigsaeure
3-Chloro-4-(2-propenyloxy)benzeneacetic acid
[4-(allyloxy)-3-chlorophenyl]acetic acid
alclofenac
alclofenaco
alclofenacum
CHEBI:31183
alclofenac
CAS:22131-79-9
ChemIDplus
Drug_Central:107
DrugCentral
PMID:18796
Europe PMC
PMID:19205
Europe PMC
PMID:21068
Europe PMC
PMID:236805
Europe PMC
PMID:237493
Europe PMC
PMID:241593
Europe PMC
PMID:241595
Europe PMC
PMID:241596
Europe PMC
PMID:241597
Europe PMC
PMID:241598
Europe PMC
PMID:241600
Europe PMC
PMID:241601
Europe PMC
PMID:241602
Europe PMC
PMID:241603
Europe PMC
PMID:24426
Europe PMC
PMID:4279126
Europe PMC
PMID:509935
Europe PMC
PMID:6103793
Europe PMC
PMID:6106453
Europe PMC
PMID:6109575
Europe PMC
PMID:6120697
Europe PMC
PMID:6141199
Europe PMC
PMID:7853459
Europe PMC
PMID:7905004
Europe PMC
Reaxys:2116510
Reaxys
A monocarboxylic acid that is glycolic acid in which the hydrogen attached to the 2-hydroxy group is replaced by a 1-benzyl-1H-indazol-3-yl group. Although it has anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties and has been used for the treatment of various inflammatory skin disorders, its principal effect is to inhibit the denaturation of proteins. Its lysine salt is used in the management of cataracts.
CAS:20187-55-7
Drug_Central:303
PMID:1809299
PMID:2190795
PMID:3176111
PMID:3508133
PMID:3817034
PMID:4099158
PMID:4389308
PMID:5746786
PMID:8483582
PMID:8736488
Reaxys:893958
[(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
BRN 0893958
EINECS 243-569-2
Iwazac
UNII-G4AG71204O
bendazac
bendazaco
bendazacum
bendazolic acid
CHEBI:31257
bendazac
CAS:20187-55-7
ChemIDplus
Drug_Central:303
DrugCentral
PMID:1809299
Europe PMC
PMID:2190795
Europe PMC
PMID:3176111
Europe PMC
PMID:3508133
Europe PMC
PMID:3817034
Europe PMC
PMID:4099158
Europe PMC
PMID:4389308
Europe PMC
PMID:5746786
Europe PMC
PMID:8483582
Europe PMC
PMID:8736488
Europe PMC
Reaxys:893958
Reaxys
CAS:2624-43-3
Drug_Central:753
Cyclofenil
cyclofenyl
cyclopenil
cyclophenil
cyclophenyl
fertodur
ondogyne
CHEBI:31446
Cyclofenil
Drug_Central:753
DrugCentral
A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
CAS:144060-53-7
DrugBank:DB04854
Drug_Central:1137
LINCS:LSM-3064
PMID:25724536
PMID:30844048
PMID:30919894
PMID:31267805
PMID:31332638
PMID:31335677
PMID:31378626
PMID:31447893
PMID:31449565
PMID:31499267
PMID:31531831
PMID:31560952
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
Adenuric
Donifoxate
Febuday
Feburic
Goturic
Goutex
TEI 6720
TEI-6720
TMX 67
TMX-67
Uloric
Zurig
febuxostat
febuxostatum
CHEBI:31596
febuxostat
CAS:144060-53-7
ChemIDplus
Drug_Central:1137
DrugCentral
PMID:25724536
Europe PMC
PMID:30844048
Europe PMC
PMID:30919894
Europe PMC
PMID:31267805
Europe PMC
PMID:31332638
Europe PMC
PMID:31335677
Europe PMC
PMID:31378626
Europe PMC
PMID:31447893
Europe PMC
PMID:31449565
Europe PMC
PMID:31499267
Europe PMC
PMID:31531831
Europe PMC
PMID:31560952
Europe PMC
A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Beilstein:497124
CAS:3820-67-5
Drug_Central:1297
LINCS:LSM-4419
PMID:19567678
PMID:2210868
Reaxys:497124
2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilate
4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride
4-(2'-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
Glafenin
Glaphenin
Glaphenine
Glicafan
Glifan
Glifanan
Glycerylaminophenaquine
glafenina
glafenine
glafeninum
CHEBI:31653
glafenine
Beilstein:497124
Beilstein
CAS:3820-67-5
ChemIDplus
CAS:3820-67-5
NIST Chemistry WebBook
Drug_Central:1297
DrugCentral
PMID:19567678
Europe PMC
PMID:2210868
Europe PMC
Reaxys:497124
Reaxys
A dicarboxylic acid amide in which a parent structure of amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.
C37H48N4O5
CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)Cc1ccccc1
CAS:192725-17-0
DrugBank:DB01601
LINCS:LSM-6027
MeSH:D061466
(2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
lopinavir
The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.
C6H5Br
Brc1ccccc1
CAS:108-86-1
MetaCyc:BROMOBENZENE
PMID:10996478
PMID:24318069
Reaxys:1236661
Wikipedia:Bromobenzene
bromobenzene
A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
CAS:61825-94-3
CAS:63121-00-6
DrugBank:DB00526
Gmelin:1046012
Gmelin:28892
LINCS:LSM-6352
PMID:11300320
PMID:14755010
PMID:15477639
PMID:17347561
PMID:18440088
PMID:19138416
PMID:19735649
PMID:27756654
PMID:28186109
PMID:28398406
PMID:28415810
PMID:28499428
PMID:28505615
PMID:28624791
PMID:28642473
PMID:28654098
PMID:28695397
PMID:28762171
PMID:28777427
PMID:28800641
PMID:28811232
PMID:28812173
PMID:28837658
PMID:28876454
PMID:28881354
PMID:28881481
PMID:28884286
PMID:28894576
PMID:28924870
PMID:28938919
Reaxys:15700099
(SP-4-2)[(1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N'][ethanedioato(2-)-kappa(2)O(1),O(2)]platinum
Oxaliplatin
(SP-4-2-(1R-trans))-(1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum
Eloxatin
oxalato(1,2-diaminocyclohexane)platinum(II)
oxaliplatin
oxaliplatine
oxaliplatino
oxaliplatinum
CHEBI:31941
oxaliplatin
CAS:63121-00-6
ChemIDplus
Gmelin:1046012
Gmelin
Gmelin:28892
Gmelin
PMID:11300320
Europe PMC
PMID:14755010
Europe PMC
PMID:15477639
Europe PMC
PMID:17347561
Europe PMC
PMID:18440088
Europe PMC
PMID:19138416
Europe PMC
PMID:19735649
Europe PMC
PMID:27756654
Europe PMC
PMID:28186109
Europe PMC
PMID:28398406
Europe PMC
PMID:28415810
Europe PMC
PMID:28499428
Europe PMC
PMID:28505615
Europe PMC
PMID:28624791
Europe PMC
PMID:28642473
Europe PMC
PMID:28654098
Europe PMC
PMID:28695397
Europe PMC
PMID:28762171
Europe PMC
PMID:28777427
Europe PMC
PMID:28800641
Europe PMC
PMID:28811232
Europe PMC
PMID:28812173
Europe PMC
PMID:28837658
Europe PMC
PMID:28876454
Europe PMC
PMID:28881354
Europe PMC
PMID:28881481
Europe PMC
PMID:28884286
Europe PMC
PMID:28894576
Europe PMC
PMID:28924870
Europe PMC
PMID:28938919
Europe PMC
Reaxys:15700099
Reaxys
A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group.
C29H41NO4
[H][C@@]1(C[C@]23CC[C@]1(OC)[C@@H]1Oc4c(O)ccc5C[C@H]2N(CC[C@@]31c45)CC1CC1)[C@](C)(O)C(C)(C)C
CAS:52485-79-7
DrugBank:DB00921
Wikipedia:Buprenorphine
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
buprenorphine
CAS:150683-30-0
Drug_Central:4110
Tolvaptan
OPC 41061
OPC-41061
jinarc
CHEBI:32246
Tolvaptan
Drug_Central:4110
DrugCentral
A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
C22H27NO2
OC(=O)CCCCCCNC1c2ccccc2CCc2ccccc12
Beilstein:2170218
CAS:57574-09-1
DrugBank:DB04836
Drug_Central:161
PMID:2131927
PMID:2141246
PMID:2698268
PMID:7609861
PMID:9347390
Reaxys:2170218
Wikipedia:Amineptine
7-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid
Amineptin
Survector
amineptine
amineptino
amineptinum
CHEBI:32499
amineptine
Beilstein:2170218
Beilstein
CAS:57574-09-1
ChemIDplus
CAS:57574-09-1
NIST Chemistry WebBook
Drug_Central:161
DrugCentral
PMID:2131927
Europe PMC
PMID:2141246
Europe PMC
PMID:2698268
Europe PMC
PMID:7609861
Europe PMC
PMID:9347390
Europe PMC
Reaxys:2170218
Reaxys
C14H14ClN3O2S
Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C
Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C
CAS:50892-23-4
LINCS:LSM-2015
PubChem:17396608
Wikipedia:Pirinixic_Acid
({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid
WY14643
pirinixic acid
Any monoacylglycerol phosphate obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid or derivatives therein.
lysophosphatidic acids
A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any long-chain (C13 to C22) fatty acid.
C22H35N7O17P3SR
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCSC([*])=O
PMID:10224157
PMID:14516204
PMID:16357361
PMID:17652214
LCFA-coenzyme A
long-chain fatty acyl-CoA
A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
antitubercular
antitubercular agents
antitubercular drug
antitubercular drugs
tuberculostatic agent
CHEBI:33231
antitubercular agent
A chemical entity constituting the smallest component of an element having the chemical properties of the element.
atom
chemical messenger
CHEBI:33280
molecular messenger
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
PMID:12964249
PMID:22117953
PMID:22439833
PMID:22849268
PMID:22849276
PMID:22958833
Antibiotika
Antibiotikum
antibiotic
antibiotics
antibiotique
antimicrobial
antimicrobial agents
antimicrobials
microbicide
microbicides
CHEBI:33281
antimicrobial agent
PMID:12964249
Europe PMC
PMID:22117953
Europe PMC
PMID:22439833
Europe PMC
PMID:22849268
Europe PMC
PMID:22849276
Europe PMC
PMID:22958833
Europe PMC
A substance (or active part thereof) that kills or slows the growth of bacteria.
A substance that kills or slows the growth of bacteria.
antibacterial agents
antibacterials
bactericide
bactericides
CHEBI:33282
antibacterial agent
Any material that can be ingested by an organism.
food role
metal atom
A macromolecule formed by a living organism.
biomacromolecule
A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
nucleic acid
ribonucleic acid
High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
RNA
ribonucleic acid
A carboxylic acid containing one or more amino groups.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
amino acid
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
MeSH:D000596
An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.
nucleoside
Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
C6HOR5
C1(=C(C(=C(C(=C1*)*)*)*)*)O
Wikipedia:Phenols
Aryl alcohol
phenols
A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Beilstein:1246090
CAS:298-46-4
DrugBank:DB00564
Drug_Central:489
LINCS:LSM-3610
PMID:10411478
PMID:11071486
PMID:11129121
PMID:11240598
PMID:11475584
PMID:11595204
PMID:11888243
PMID:11891095
PMID:12073283
PMID:12228880
PMID:12475188
PMID:12749779
PMID:12799799
PMID:12957643
PMID:14160216
PMID:14572037
PMID:14581052
PMID:14713026
PMID:14723323
PMID:15165631
PMID:15557493
PMID:15665743
PMID:15683742
PMID:15739418
PMID:15820347
PMID:15850602
PMID:16033627
PMID:16150575
PMID:16245817
PMID:16380297
PMID:16394456
PMID:16437428
PMID:16538175
PMID:16562645
PMID:16616830
PMID:16990009
PMID:17027750
PMID:17028629
PMID:17207414
PMID:17582711
PMID:17873967
PMID:17949959
PMID:18163657
PMID:18415623
PMID:18637155
PMID:18652684
PMID:18656520
PMID:18969759
PMID:19135617
PMID:19473818
PMID:19741433
PMID:19921623
PMID:22322005
PMID:27967303
PMID:7602118
Reaxys:1246090
5H-dibenzo[b,f]azepine-5-carboxamide
5-Carbamoyl-5H-dibenz(b,f)azepine
5-Carbamoyl-5H-dibenzo(b,f)azepine
5-Carbamyl-5H-dibenzo(b,f)azepine
5-carbamoyl-5H-dibenz[b,f]azepine
5H-Dibenz(b,f)azepine-5-carboxamide
Carbamazepen
Carnexiv
carbamazepina
carbamazepine
carbamazepinum
CHEBI:3387
carbamazepine
Beilstein:1246090
Beilstein
CAS:298-46-4
ChemIDplus
CAS:298-46-4
NIST Chemistry WebBook
Drug_Central:489
DrugCentral
PMID:10411478
ChEMBL
PMID:11071486
Europe PMC
PMID:11129121
Europe PMC
PMID:11240598
Europe PMC
PMID:11475584
Europe PMC
PMID:11595204
Europe PMC
PMID:11888243
Europe PMC
PMID:11891095
Europe PMC
PMID:12073283
Europe PMC
PMID:12228880
Europe PMC
PMID:12475188
Europe PMC
PMID:12749779
Europe PMC
PMID:12799799
Europe PMC
PMID:12957643
Europe PMC
PMID:14160216
Europe PMC
PMID:14572037
Europe PMC
PMID:14581052
Europe PMC
PMID:14713026
Europe PMC
PMID:14723323
Europe PMC
PMID:15165631
Europe PMC
PMID:15557493
Europe PMC
PMID:15665743
Europe PMC
PMID:15683742
Europe PMC
PMID:15739418
Europe PMC
PMID:15820347
Europe PMC
PMID:15850602
Europe PMC
PMID:16033627
Europe PMC
PMID:16150575
Europe PMC
PMID:16245817
Europe PMC
PMID:16380297
Europe PMC
PMID:16394456
Europe PMC
PMID:16437428
Europe PMC
PMID:16538175
Europe PMC
PMID:16562645
Europe PMC
PMID:16616830
Europe PMC
PMID:16990009
Europe PMC
PMID:17027750
Europe PMC
PMID:17028629
Europe PMC
PMID:17207414
Europe PMC
PMID:17582711
Europe PMC
PMID:17873967
Europe PMC
PMID:17949959
Europe PMC
PMID:18163657
Europe PMC
PMID:18415623
Europe PMC
PMID:18637155
Europe PMC
PMID:18652684
Europe PMC
PMID:18656520
Europe PMC
PMID:18969759
Europe PMC
PMID:19135617
Europe PMC
PMID:19473818
Europe PMC
PMID:19741433
Europe PMC
PMID:19921623
Europe PMC
PMID:22322005
Europe PMC
PMID:27967303
Europe PMC
PMID:7602118
Europe PMC
Reaxys:1246090
Reaxys
CAS:1477-19-6
Drug_Central:317
Benzarone
2-Ethyl-3-(4-hydroxybenzoyl)benzofuran
benzaron
CHEBI:34559
benzarone
Drug_Central:317
DrugCentral
A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
C4H10N2O
CCN(CC)N=O
CAS:55-18-5
N-ethyl-N-nitrosoethanamine
DEN
Diethylnitrosamine
N-nitrosodiethylamine
A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
antimetabolite
antimetabolites
CHEBI:35221
antimetabolite
A substance that diminishes the rate of a chemical reaction.
inhibitor
inhibidor
inhibiteur
inhibitors
CHEBI:35222
inhibitor
A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
catalyst
Any drug that enhances the activity of the central nervous system.
central nervous system stimulant
CNS stimulant
analeptic
analeptic agent
analeptic drug
analeptics
central stimulant
CHEBI:35337
central nervous system stimulant
Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from triterpenoids.
SMILES: C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C
steroids
steroid
Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.
Monosaccharide
monosaccharide
monosaccharides
monosaccharide
A substance used in the prophylaxis or therapy of infectious diseases.
anti-infective agents
anti-infective drugs
antiinfective agents
antiinfective drug
CHEBI:35441
antiinfective agent
A substance used to treat or prevent parasitic infections.
antiparasitic drugs
antiparasitics
parasiticides
CHEBI:35442
antiparasitic agent
Substance intended to kill parasitic worms (helminths).
anthelminthic
anthelminthics
anthelmintic
anthelmintics
antihelminth
antihelmintico
vermifuge
CHEBI:35443
anthelminthic drug
A substance used in the treatment or control of nematode infestations.
antinematodal agent
antinematodal drugs
antinematodals
CHEBI:35444
antinematodal drug
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
antidepressant drugs
antidepressants
thymoanaleptics
thymoleptic drugs
thymoleptics
CHEBI:35469
antidepressant
A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
CNS agent
CNS drugs
central nervous system agents
CHEBI:35470
central nervous system drug
A loosely defined grouping of drugs that have effects on psychological function.
Wikipedia:Psychotropic_drug
psychoactive agent
psychoactive drugs
psychopharmaceuticals
psychotropic drugs
CHEBI:35471
psychotropic drug
A substance that reduces or suppresses inflammation.
anti-inflammatory drugs
antiinflammatory agent
antiinflammatory drug
antiinflammatory drugs
CHEBI:35472
anti-inflammatory drug
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.
ataractics
tranquilising drug
tranquilizing drugs
tranquillising agent
tranquillizing agents
CHEBI:35473
tranquilizing drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
anti-anxiety agents
anti-anxiety drugs
anxiolytic agents
anxiolytics
minor tranquilisers
minor tranquilizers
minor tranquilizing agents
CHEBI:35474
anxiolytic drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Wikipedia:Non-steroidal_anti-inflammatory_drug
NSAID
NSAIDs
non-steroidal anti-inflammatory agent
non-steroidal anti-inflammatory drugs
CHEBI:35475
non-steroidal anti-inflammatory drug
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
Neuroleptikum
antipsychotic agents
antipsychotic drug
antipsychotic drugs
antipsychotics
antipsychotiques
grosser Tranquilizer
major tranquilizers
major tranquilizing agents
neuroleptic
neuroleptic agents
neuroleptics
neuroleptique
neuroleptiques
CHEBI:35476
antipsychotic agent
Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
antimanic agent
antimanic drugs
antimanics
CHEBI:35477
antimanic drug
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
CHEBI:35480
analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
CHEBI:35481
non-narcotic analgesic
An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of aldehyde dehydrogenase (NAD(+)), EC 1.2.1.3.
CoA-independent aldehyde dehydrogenase inhibitor
CoA-independent aldehyde dehydrogenase inhibitors
EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitor
EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitors
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitors
EC 1.2.1.3 inhibitor
EC 1.2.1.3 inhibitors
NAD-aldehyde dehydrogenase inhibitor
NAD-aldehyde dehydrogenase inhibitors
NAD-dependent 4-hydroxynonenal dehydrogenase inhibitor
NAD-dependent 4-hydroxynonenal dehydrogenase inhibitors
NAD-dependent aldehyde dehydrogenase inhibitor
NAD-dependent aldehyde dehydrogenase inhibitors
NAD-linked aldehyde dehydrogenase inhibitor
NAD-linked aldehyde dehydrogenase inhibitors
aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitor
aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitors
aldehyde dehydrogenase (NAD(+)) inhibitor
aldehyde dehydrogenase (NAD(+)) inhibitors
aldehyde dehydrogenase (NAD) inhibitor
aldehyde dehydrogenase (NAD) inhibitors
aldehyde dehydrogenase inhibitor
aldehyde dehydrogenase inhibitors
m-methylbenzaldehyde dehydrogenase inhibitor
m-methylbenzaldehyde dehydrogenase inhibitors
propionaldehyde dehydrogenase inhibitor
propionaldehyde dehydrogenase inhibitors
CHEBI:35487
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
CNS depressants
central nervous system depressants
CHEBI:35488
central nervous system depressant
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
anti-pyretic
CHEBI:35493
antipyretic
A compound which inhibits or antagonises the biosynthesis or actions of androgens.
antiandrogen
CHEBI:35497
androgen antagonist
An agent that promotes the excretion of urine through its effects on kidney function.
diuretics
CHEBI:35498
diuretic
A drug which lowers the blood glucose level.
antidiabetic
antihyperglycemic
antihyperglycemic agent
antihyperglycemic agents
antihyperglycemic drug
antihyperglycemic drugs
antihyperglycemics
hypoglycemic agents
hypoglycemic drug
hypoglycemic drugs
CHEBI:35526
hypoglycemic agent
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
beta-adrenergic antagonists
beta-adrenergic blocker
beta-adrenergic blockers
beta-adrenergic receptor blockaders
beta-adrenoceptor antagonists
beta-blocker
beta-blockers
CHEBI:35530
beta-adrenergic antagonist
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors
(PG)H synthase inhibitor
(PG)H synthase inhibitors
COX inhibitor
EC 1.14.99.1 (cyclooxygenase) inhibitor
EC 1.14.99.1 (cyclooxygenase) inhibitors
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors
EC 1.14.99.1 inhibitor
EC 1.14.99.1 inhibitors
PG synthetase inhibitor
PG synthetase inhibitors
cyclooxygenase (EC 1.14.99.1) inhibitor
cyclooxygenase (EC 1.14.99.1) inhibitors
cyclooxygenase inhibitor
cyclooxygenase inhibitors
fatty acid cyclooxygenase inhibitor
fatty acid cyclooxygenase inhibitors
prostaglandin G/H synthase inhibitor
prostaglandin G/H synthase inhibitors
prostaglandin endoperoxide synthetase inhibitor
prostaglandin endoperoxide synthetase inhibitors
prostaglandin synthase inhibitor
prostaglandin synthase inhibitors
prostaglandin synthetase inhibitor
prostaglandin synthetase inhibitors
CHEBI:35544
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A fluoroalkanoic acid that is perfluorinated octanoic acid.
C8HF15O2
OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
CAS:335-67-1
Wikipedia:Perfluorooctanoic_acid
PFOA
pentadecafluorooctanoic acid
perfluorooctanoate
Perfluorooctanoic acid
Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. (by Wikipedia)
C19H35N
C1CCC(CC1)C(CC1CCCCN1)C1CCCCC1
Beilstein:4979856
CAS:6621-47-2
DrugBank:DB01074
Drug_Central:2106
LINCS:LSM-4353
Wikipedia:Perhexiline
2-(2,2-dicyclohexylethyl)piperidine
Perhexiline
Perhexilene
CHEBI:35553
perhexiline
Beilstein:4979856
Beilstein
CAS:6621-47-2
ChemIDplus
CAS:6621-47-2
NIST Chemistry WebBook
Drug_Central:2106
DrugCentral
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
cardiovascular agent
cardiovascular drugs
CHEBI:35554
cardiovascular drug
An agent that selectively binds to and activates alpha-adrenergic receptors.
alpha-adrenergic agonists
alpha-adrenergic receptor agonist
alpha-adrenoceptor agonists
CHEBI:35569
alpha-adrenergic agonist
C9H14O
CC(C)=CC(=O)C=C(C)C
CAS:504-20-1
2,6-dimethylhepta-2,5-dien-4-one
phorone
A substance that inhibits or prevents the proliferation of neoplasms.
anticancer agent
anticancer agents
antineoplastic
antineoplastic agents
cytostatic
CHEBI:35610
antineoplastic agent
A drug used to cause dilation of the blood vessels.
vasodilator
vasodilator agents
CHEBI:35620
vasodilator agent
A drug used to prevent seizures or reduce their severity.
Antiepileptika
Antiepileptikum
Antikonvulsiva
Antikonvulsivum
anti-convulsant
anti-convulsants
anti-convulsive agent
anti-convulsive agents
anticonvulsants
anticonvulsive agent
anticonvulsive agents
antiepileptic
antiepileptics
antiepileptique
antiepileptiques
CHEBI:35623
anticonvulsant
An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).
EC 1.17.3.2 (xanthine oxidase) inhibitors
EC 1.17.3.2 inhibitor
EC 1.17.3.2 inhibitors
Schardinger enzyme inhibitor
Schardinger enzyme inhibitors
hypoxanthine oxidase inhibitor
hypoxanthine oxidase inhibitors
hypoxanthine-xanthine oxidase inhibitor
hypoxanthine-xanthine oxidase inhibitors
hypoxanthine:oxygen oxidoreductase inhibitor
hypoxanthine:oxygen oxidoreductase inhibitors
xanthine oxidase (EC 1.17.3.2) inhibitor
xanthine oxidase (EC 1.17.3.2) inhibitors
xanthine oxidase inhibitor
xanthine oxidase inhibitors
xanthine oxidoreductase inhibitor
xanthine oxidoreductase inhibitors
xanthine:O2 oxidoreductase inhibitor
xanthine:O2 oxidoreductase inhibitors
xanthine:oxygen oxidoreductase inhibitor
xanthine:oxygen oxidoreductase inhibitors
xanthine:xanthine oxidase inhibitor
xanthine:xanthine oxidase inhibitors
CHEBI:35634
EC 1.17.3.2 (xanthine oxidase) inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
ARI
NERI
NRI
adrenergic reuptake inhibitor
adrenergic reuptake inhibitors
adrenergic uptake inhibitors
norepinephrine reuptake inhibitor
norepinephrine reuptake inhibitors
CHEBI:35640
adrenergic uptake inhibitor
An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly.
Wikipedia:Protease_inhibitor_(pharmacology)
HIV protease inhibitors
CHEBI:35660
HIV protease inhibitor
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
antihypertensive
antihypertensive agents
antihypertensive drug
antihypertensive drugs
CHEBI:35674
antihypertensive agent
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
antihyperlipemic
antihyperlipemics
antihyperlipidemic
antihyperlipidemic agent
antihyperlipidemic agents
antihyperlipidemic drug
antihyperlipidemic drugs
antihyperlipidemics
antilipemic
antilipemic drugs
antilipemics
hypolipidemic agent
hypolipidemic agents
CHEBI:35679
antilipemic drug
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Wikipedia:Xenobiotic
Xenobiotic
xenobiotic
xenobiotics
xenobiotic compounds
CHEBI:35703
xenobiotic
xenobiotics
IUPAC
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
immunosuppressant
immunosuppressive agents
inmunosupresor
CHEBI:35705
immunosuppressive agent
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
hypnotics
hypnotics and sedatives
sedative drug
sedatives
sedatives and hypnotics
CHEBI:35717
sedative
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antifungal
antifungal agents
antifungal drug
antifungal drugs
antifungals
CHEBI:35718
antifungal agent
Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.
IMR:0001382
glycerolipid
glycerophosphoserine
http://purl.obolibrary.org/obo/IMR_0001383
sphingophospholipid
phosphosphingolipid
A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions.
leprostatic
leprostatic agent
leprostatic drugs
CHEBI:35816
leprostatic drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
antiprotozoal agent
antiprotozoal agents
antiprotozoal drugs
CHEBI:35820
antiprotozoal drug
A substance used to lower plasma cholesterol levels.
anticholesteremic drug
A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
uricosuric agent
uricosuric drugs
CHEBI:35841
uricosuric drug
A drug used to treat rheumatoid arthritis.
anti-rheumatic drugs
antirheumatic agent
antirheumatic drugs
CHEBI:35842
antirheumatic drug
A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout.
gout suppressants
CHEBI:35845
gout suppressant
A drug used for its effect on the kidneys' regulation of body fluid composition and volume.
renal agents
CHEBI:35846
renal agent
A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
lipooxygenase inhibitor
lipoxygenase inhibitors
CHEBI:35856
lipoxygenase inhibitor
A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
neurotransmitter agents
CHEBI:35942
neurotransmitter agent
A drug used to treat or prevent microbial infections.
antimicrobial drugs
CHEBI:36043
antimicrobial drug
A substance used in the prophylaxis or therapy of virus diseases.
anti-viral drug
anti-virus drug
antiviral drugs
CHEBI:36044
antiviral drug
A drug used to treat or prevent bacterial infections.
Wikipedia:Antibacterial
antibacterial drugs
CHEBI:36047
antibacterial drug
An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA.
http://purl.obolibrary.org/obo/PR_000000001
protein
A 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions.
Beilstein:23033
CAS:80-77-3
DrugBank:DB01178
Drug_Central:603
LINCS:LSM-4356
PMID:10191862
PMID:10412893
PMID:10798243
PMID:15897685
PMID:29438107
PMID:3449070
PMID:3720548
PMID:3768082
PMID:6403110
PMID:7104168
PMID:7758315
PMID:9770210
Reaxys:23033
2-(4-chlorophenyl)-3-methyl-1,3-thiazinan-4-one 1,1-dioxide
(+-)-chlormezanone
2-(p-chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
2-(p-chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
chlormethazanone
chlormezanona
chlormezanone
chlormezanonum
CHEBI:3619
chlormezanone
Beilstein:23033
Beilstein
CAS:80-77-3
ChemIDplus
Drug_Central:603
DrugCentral
PMID:10191862
Europe PMC
PMID:10412893
Europe PMC
PMID:10798243
Europe PMC
PMID:15897685
Europe PMC
PMID:29438107
Europe PMC
PMID:3449070
Europe PMC
PMID:3720548
Europe PMC
PMID:3768082
Europe PMC
PMID:6403110
Europe PMC
PMID:7104168
Europe PMC
PMID:7758315
Europe PMC
PMID:9770210
Europe PMC
Reaxys:23033
Reaxys
glycerophosphoethanolamine
Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.
PMID:14706866
glycerophosphoinositols
glycerophosphoinositol
A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
antitrypanosomal agent
antitrypanosomal agents
antitrypanosomal drug
antitrypanosomal drugs
trypanocidal drugs
trypanocide
trypanosomicidal agents
CHEBI:36335
trypanocidal drug
Any molecular entity consisting of more than one atom.
polyatomic entity
An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
C2H2Cl2O2
OC(=O)C(Cl)Cl
CAS:79-43-6
Wikipedia:Dichloroacetic_acid
dichloroacetic acid
A compound which stimulates anabolism and inhibits catabolism. Anabolic agents stimulate the development of muscle mass, strength, and power.
CHEBI:36413
anabolic agent
A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
C17H19ClN2S
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
CAS:50-53-3
DrugBank:DB00477
LINCS:LSM-4017
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
chlorpromazine
A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Beilstein:638882
CAS:95-25-0
DrugBank:DB00356
Drug_Central:626
LINCS:LSM-6011
PMID:10640318
PMID:11727787
PMID:12437348
PMID:16763012
PMID:16859676
PMID:17621748
PMID:21195386
PMID:23975871
PMID:24210069
PMID:25815637
PMID:6631711
Reaxys:638882
5-chloro-1,3-benzoxazol-2-ol
CHLORZOXAZONE
Chlorzoxazone
2-hydroxy-5-chlorobenzoxazole
5-chloro-2(3H)-benzoxazolone
5-chloro-2-benzoxazolinone
5-chloro-2-benzoxazolol
5-chloro-2-benzoxazolone
5-chloro-2-hydroxybenzoxazole
5-chlorobenzoxazolidone
5-chlorobenzoxazolin-2-one
chlorzoxane
chlorzoxazona
chlorzoxazone
chlorzoxazonum
CHEBI:3655
chlorzoxazone
Beilstein:638882
Beilstein
CAS:95-25-0
ChemIDplus
CAS:95-25-0
NIST Chemistry WebBook
Drug_Central:626
DrugCentral
PMID:10640318
Europe PMC
PMID:11727787
Europe PMC
PMID:12437348
Europe PMC
PMID:16763012
Europe PMC
PMID:16859676
Europe PMC
PMID:17621748
Europe PMC
PMID:21195386
Europe PMC
PMID:23975871
Europe PMC
PMID:24210069
Europe PMC
PMID:25815637
Europe PMC
PMID:6631711
Europe PMC
Reaxys:638882
Reaxys
phosphoethanolamine
An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.
Beilstein:7960555
CAS:206361-99-1
DrugBank:DB01264
Drug_Central:4143
PMID:15771427
PMID:16480273
PMID:25017682
Reaxys:7960555
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
Darunavir
(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate
(3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
(3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
N-((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide
TMC114
[(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester
darunavir
darunavirum
{(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester
CHEBI:367163
darunavir
Beilstein:7960555
Beilstein
CAS:206361-99-1
ChemIDplus
Drug_Central:4143
DrugCentral
PMID:15771427
ChEMBL
PMID:16480273
ChEMBL
PMID:25017682
Europe PMC
Reaxys:7960555
Reaxys
Beilstein:8842375
CAS:116539-58-3
PMID:20825390
N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine
N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
CHEBI:36796
duloxetine
Beilstein:8842375
Beilstein
CAS:116539-58-3
ChemIDplus
PMID:20825390
Europe PMC
A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.
A nucleotide consists of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Nucleotides can carry chemical energy (e.g. ATP), form coenzymes (e.g. CoA), be used as specific signaling molecules (e.g. cAMP) in the cell. Nucleotides are the subunits of the nucleic acids.
IMR:0001349
nucleotide
A nucleotide consists of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Nucleotides can carry chemical energy (e.g. ATP), form coenzymes (e.g. CoA), be used as specific signaling molecules (e.g. cAMP) in the cell. Nucleotides are the subunits of the nucleic acids.
ISBN:0815340729
Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16).
3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor
3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors
Aspergillus awamori acid protein phosphatase inhibitor
Aspergillus awamori acid protein phosphatase inhibitors
BCKDH phosphatase inhibitor
BCKDH phosphatase inhibitors
EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors
EC 3.1.3.16 inhibitor
EC 3.1.3.16 inhibitors
HMG-CoA reductase phosphatase inhibitor
HMG-CoA reductase phosphatase inhibitors
branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor
branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors
calcineurin inhibitor
calcineurin inhibitors
casein phosphatase inhibitor
casein phosphatase inhibitors
phosphatase 2A inhibitor
phosphatase 2A inhibitors
phosphatase 2B inhibitor
phosphatase 2B inhibitors
phosphatase C-II inhibitor
phosphatase C-II inhibitors
phosphatase H-II inhibitor
phosphatase H-II inhibitors
phosphatase I inhibitor
phosphatase I inhibitors
phosphatase IB inhibitor
phosphatase IB inhibitors
phosphatase II inhibitor
phosphatase II inhibitors
phosphatase III inhibitor
phosphatase III inhibitors
phosphatase IV inhibitor
phosphatase IV inhibitors
phosphatase SP inhibitor
phosphatase SP inhibitors
phosphoprotein phosphatase (EC 3.1.3.16) inhibitor
phosphoprotein phosphatase (EC 3.1.3.16) inhibitors
phosphoprotein phosphatase inhibitor
phosphoprotein phosphatase inhibitors
phosphoprotein phosphohydrolase inhibitor
phosphoprotein phosphohydrolase inhibitors
phosphopyruvate dehydrogenase phosphatase inhibitor
phosphopyruvate dehydrogenase phosphatase inhibitors
phosphospectrin phosphatase inhibitor
phosphospectrin phosphatase inhibitors
polycation modulated (PCM-) phosphatase inhibitor
polycation modulated (PCM-) phosphatase inhibitors
protein D phosphatase inhibitor
protein D phosphatase inhibitors
protein phosphatase inhibitor
protein phosphatase inhibitors
protein phosphatase-1 inhibitor
protein phosphatase-1 inhibitors
protein phosphatase-2A inhibitor
protein phosphatase-2A inhibitors
protein phosphatase-2B inhibitor
protein phosphatase-2B inhibitors
protein phosphatase-2C inhibitor
protein phosphatase-2C inhibitors
protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors
protein serine/threonine phosphatase inhibitor
protein serine/threonine phosphatase inhibitors
serine/threonine specific protein phosphatase inhibitor
serine/threonine specific protein phosphatase inhibitors
CHEBI:37153
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.
Beilstein:3581974
CAS:81103-11-9
DrugBank:DB01211
Drug_Central:668
LINCS:LSM-5606
LIPID_MAPS_instance:LMPK04000014
PMID:16387493
Reaxys:3581974
CLARITHROMYCIN
Clarithromycin
O(6)-methylerythromycin
6-O-methylerythromycin
6-O-methylerythromycin A
CLA
clarithromycin
clarithromycina
clarithromycine
clarithromycinum
CHEBI:3732
clarithromycin
Beilstein:3581974
Beilstein
CAS:81103-11-9
ChemIDplus
Drug_Central:668
DrugCentral
LIPID_MAPS_instance:LMPK04000014
LIPID MAPS
PMID:16387493
ChEMBL
Reaxys:3581974
Reaxys
phosphatidylinositol bisphosphate
The ethyl ester of clofibric acid.
C12H15ClO3
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
LINCS:LSM-2996
Open TG-Gates compound_id:00006
Wikipedia:Clofibrate
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
clofibrate
An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
acid
A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems.
IMR:0100179
S1P
sphingosine-1-phosphate
Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems.
PMID:15059942
An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any fatty acid.
C22H35N7O17P3SR
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCSC([*])=O
PMID:11524729
PMID:20442897
PMID:2079609
fatty acyl-CoA
A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Beilstein:0764984
CAS:5786-21-0
DrugBank:DB00363
Drug_Central:722
PMID:18690109
PMID:18766167
PMID:20825390
PMID:24219174
Reaxys:764984
8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Clozapine
Clozapin
clozapina
clozapine
clozapinum
CHEBI:3766
clozapine
Beilstein:0764984
Beilstein
CAS:5786-21-0
ChemIDplus
Drug_Central:722
DrugCentral
PMID:18690109
Europe PMC
PMID:18766167
Europe PMC
PMID:20825390
Europe PMC
PMID:24219174
Europe PMC
Reaxys:764984
Reaxys
A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).
protease inhibitors
CHEBI:37670
protease inhibitor
An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases.
protein kinase inhibitors
CHEBI:37699
protein kinase inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor
ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors
EC 2.7.11.13 (protein kinase C) inhibitors
EC 2.7.11.13 inhibitor
EC 2.7.11.13 inhibitors
PKC inhibitor
PKC inhibitors
PKCalpha inhibitor
PKCalpha inhibitors
PKCbeta inhibitor
PKCbeta inhibitors
PKCdelta inhibitor
PKCdelta inhibitors
PKCepsilon inhibitor
PKCepsilon inhibitors
PKCgamma inhibitor
PKCgamma inhibitors
PKCzeta inhibitor
PKCzeta inhibitors
PKN3 inhibitor
PKN3 inhibitors
Pkc1p inhibitor
Pkc1p inhibitors
STK24 inhibitor
STK24 inhibitors
cPKC inhibitor
cPKC inhibitors
cPKCalpha inhibitor
cPKCalpha inhibitors
cPKCbeta inhibitor
cPKCbeta inhibitors
cPKCgamma inhibitor
cPKCgamma inhibitors
calcium-dependent protein kinase C inhibitor
calcium-dependent protein kinase C inhibitors
calcium-independent protein kinase C inhibitor
calcium-independent protein kinase C inhibitors
calcium/phospholipid dependent protein kinase inhibitor
calcium/phospholipid dependent protein kinase inhibitors
nPKC inhibitor
nPKC inhibitors
nPKCdelta inhibitor
nPKCdelta inhibitors
nPKCepsilon inhibitor
nPKCepsilon inhibitors
nPKCeta inhibitor
nPKCeta inhibitors
nPKCtheta inhibitor
nPKCtheta inhibitors
protein kinase C (EC 2.7.11.13) inhibitor
protein kinase C (EC 2.7.11.13) inhibitors
protein kinase C inhibitor
protein kinase C inhibitors
protein kinase Cepsilon inhibitor
protein kinase Cepsilon inhibitors
CHEBI:37700
EC 2.7.11.13 (protein kinase C) inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
BChE inhibitor
BChE inhibitors
BtChoEase inhibitor
BtChoEase inhibitors
EC 3.1.1.8 (cholinesterase) inhibitors
EC 3.1.1.8 inhibitor
EC 3.1.1.8 inhibitors
anticholineesterase inhibitor
anticholineesterase inhibitors
anticholinesterase
anticholinesterases
benzoylcholinesterase inhibitor
benzoylcholinesterase inhibitors
butyrylcholine esterase inhibitor
butyrylcholine esterase inhibitors
butyrylcholinesterase inhibitor
butyrylcholinesterase inhibitors
choline esterase II (unspecific) inhibitor
choline esterase II (unspecific) inhibitors
choline esterase inhibitor
choline esterase inhibitors
cholinesterase (EC 3.1.1.8) inhibitor
cholinesterase (EC 3.1.1.8) inhibitors
cholinesterase inhibitor
non-specific cholinesterase inhibitor
non-specific cholinesterase inhibitors
propionylcholinesterase inhibitor
propionylcholinesterase inhibitors
pseudocholinesterase inhibitor
pseudocholinesterase inhibitors
CHEBI:37733
EC 3.1.1.8 (cholinesterase) inhibitor
phosphoric ester
Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.
PMID:17393491
http://purl.obolibrary.org/obo/IMR_0001384
phosphatide
phosphoglyceride
glycerophospholipid
Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.
CHEBI:37739
A hormone that specifically regulates growth.
CAS:9002-72-6
growth hormone
An agent that selectively binds to and activates adrenergic receptors.
adrenergic agonists
adrenergic receptor agonist
adrenoceptor agonists
adrenomimetic
adrenomimetics
CHEBI:37886
adrenergic agonist
An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
adrenergic antagonists
adrenergic blockaders
adrenergic blocker
adrenergic blockers
adrenergic receptor blockaders
adrenoceptor antagonists
CHEBI:37887
adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
alpha-adrenergic antagonists
alpha-adrenergic blocker
alpha-adrenergic blockers
alpha-adrenergic receptor blockaders
alpha-adrenoceptor antagonists
CHEBI:37890
alpha-adrenergic antagonist
A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).
COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(cc1)-c1ccccn1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
CAS:198904-31-3
DrugBank:DB01072
Wikipedia:Atazanavir
dimethyl (3S,8S,9S,12S)-9-benzyl-3,12-di-tert-butyl-8-hydroxy-4,11-dioxo-6-[4-(2-pyridyl)benzyl]-2,5,6,10,13-pentaazatetradecanedioate
atazanavir
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
PMID:22035879
antihistamine
antihistamines
antihistaminico
antihistaminics
histamine receptor blocker
histamine receptor blockers
CHEBI:37956
histamine antagonist
PMID:22035879
Europe PMC
Drugs used for their actions on histaminergic systems.
histamine agents
histamine drugs
histaminergic agent
histaminergic agents
histaminergic drugs
CHEBI:37957
histaminergic drug
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
adrenergic agents
adrenergic drug
adrenergic drugs
adrenergic neuron agents
adrenergics
CHEBI:37962
adrenergic agent
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
antimalarials
CHEBI:38068
antimalarial
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
antiarrhythmic agent
CHEBI:38070
anti-arrhythmia drug
A drug that has a strengthening effect on the heart or that can increase cardiac output.
cardiotonic drug
iron chelating agents
iron chelators
CHEBI:38157
iron chelator
A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
Chelating agent
Metal chelator
chelating agents
chelators
complexon
CHEBI:38161
chelator
A hydrochloride that is the monohydrochloride salt of methapyrilene.
C14H19N3S.ClH
C14H20ClN3S
Cl.CN(C)CCN(Cc1cccs1)c1ccccn1
CAS:135-23-9
DrugBank:DB04819
N,N-dimethyl-N'-pyridin-2-yl-N'-[(thiophen-2-yl)methyl]ethane-1,2-diamine hydrochloride
Methapyrilene hydrochloride
A member of the class of phhenylureas that is urea in which one of the nitrogens is substituted by a p-chlorophenyl group while the other is substituted by two methyl groups.
C9H11ClN2O
CN(C)C(=O)Nc1ccc(Cl)cc1
CAS:150-68-5
3-(4-chlorophenyl)-1,1-dimethylurea
Monuron
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
calcium channel antagonist
calcium channel antagonists
calcium channel blockers
CHEBI:38215
calcium channel blocker
A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
C34H59NO15
CCCC[C@H]([C@H]([C@H](C[C@H](C[C@@H](CCCC[C@H](C[C@@H]([C@H](C)N)O)O)O)C)OC(C[C@@H](CC(=O)O)C(=O)O)=O)OC(=O)C[C@@H](CC(O)=O)C(=O)O)C
CAS:116355-83-0
(2R,2'R)-2,2'-{[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-11,16,18-trihydroxy-5,9-dimethylicosane-6,7-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}dibutanedioic acid
fumonisin B1
Any inhibitor of a DNA polymerase.
CHEBI:38234
DNA polymerase inhibitor
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
cholinergic agent
cholinergic drugs
cholinomimetic
CHEBI:38323
cholinergic drug
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
EC 3.1.1.7 (acetylcholinesterase) inhibitor role
acetylcholinesterase inhibitor role
A role played by the entity that inhibits the electron-transport chain
CHEBI:38496
electron-transport chain inhibitor
A role played by the entity that inhibits the respiratory-chain.
CHEBI:38497
respiratory-chain inhibitor
A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H(+)-translocating), EC 1.6.5.3.
DPNH-coenzyme Q reductase inhibitor
DPNH-ubiquinone reductase inhibitor
EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor
EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors
EC 1.6.5.3 inhibitor
EC 1.6.5.3 inhibitors
NADH coenzyme Q1 reductase inhibitor
NADH coenzyme Q1 reductase inhibitors
NADH dehydrogenase (ubiquinone) inhibitor
NADH dehydrogenase (ubiquinone) inhibitors
NADH-CoQ oxidoreductase inhibitor
NADH-CoQ oxidoreductase inhibitors
NADH-CoQ reductase inhibitor
NADH-CoQ reductase inhibitors
NADH-Q6 oxidoreductase inhibitor
NADH-coenzyme Q oxidoreductase inhibitors
NADH-coenzyme Q reductase inhibitor
NADH-coenzyme Q reductase inhibitors
NADH-ubiquinone oxidoreductase inhibitor
NADH-ubiquinone oxidoreductase inhibitors
NADH-ubiquinone reductase inhibitor
NADH-ubiquinone reductase inhibitors
NADH-ubiquinone-1 reductase inhibitor
NADH-ubiquinone-1 reductase inhibitors
NADH2 dehydrogenase (ubiquinone) inhibitor
NADH:ubiquinone oxidoreductase complex inhibitor
NADH:ubiquinone oxidoreductase inhibitor
NADH:ubiquinone oxidoreductase inhibitors
NADH:ubiquinone reductase (H(+)-translocating) inhibitor
NADH:ubiquinone reductase (H(+)-translocating) inhibitors
NADH:ubiquinone reductase (H+-translocating) inhibitor
NADH:ubiquinone reductase inhibitor
coenzyme Q reductase
complex 1 dehydrogenase inhibitor
complex I (NADH:Q1 oxidoreductase) inhibitors
complex I (electron transport chain) inhibitors
complex I (mitochondrial electron transport) inhibitors
dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
electron transfer complex I inhibitor
electron transfer complex I inhibitors
mitochondrial electron transport complex 1 inhibitor
mitochondrial electron transport complex I inhibitor
mitochondrial electron transport complex I inhibitors
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors
type 1 dehydrogenase inhibitor
type 1 dehydrogenase inhibitors
ubiquinone reductase inhibitor
ubiquinone reductase inhibitors
CHEBI:38503
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
Any agent that affects the transport of molecular entities across a biological membrane.
membrane transport modulators
CHEBI:38632
membrane transport modulator
An agent that inhibits sodium influx through cell membranes.
Na channel blocker
sodium channel blockers
CHEBI:38633
sodium channel blocker
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
TKI inhibitor
TKI inhibitors
protein tyrosine kinase inhibitor
protein tyrosine kinase inhibitors
tyrosine kinase inhibitors
tyrphostin
tyrphostins
CHEBI:38637
tyrosine kinase inhibitor
Agents that increase calcium influx into calcium channels of excitable tissues.
calcium channel activator
calcium channel agonist
A membrane transport modulator that is able to regulate intracellular calcium levels.
calcium channel modulators
CHEBI:38808
calcium channel modulator
RyR modulator
ryanodine receptor modulator
CAS:557795-19-4
DrugBank:DB01268
Drug_Central:2544
PMID:12531805
PMID:16845442
PMID:16916320
PMID:17327610
PMID:17962201
PMID:18971320
PMID:19830602
PMID:20406969
PMID:21792888
PMID:24188025
PMID:24393200
PMID:24402960
PMID:24403097
PMID:24521256
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Sunitinib
SU-11248
Sutent
sunitinib
sunitinibum
CHEBI:38940
sunitinib
CAS:557795-19-4
ChemIDplus
Drug_Central:2544
DrugCentral
PMID:12531805
Europe PMC
PMID:16845442
Europe PMC
PMID:16916320
Europe PMC
PMID:17327610
Europe PMC
PMID:17962201
Europe PMC
PMID:18971320
Europe PMC
PMID:19830602
Europe PMC
PMID:20406969
Europe PMC
PMID:21792888
Europe PMC
PMID:24188025
Europe PMC
PMID:24393200
Europe PMC
PMID:24402960
Europe PMC
PMID:24403097
Europe PMC
PMID:24521256
Europe PMC
sodium channel modulators
CHEBI:39000
sodium channel modulator
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. They are synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport).
HDL
high-density lipoprotein
A class of lipoproteins of large size (30-80 nm), very low density (0.93-1.006 g/ml) particles with a core composed mainly of triglycerides and a surface monolayer of phospholipids and cholesterol into which are imbedded the apolipoproteins B, E, and C. VLDL facilitate the transport of endogenously made triglycerides to extrahepatic tissues.
VLDL
very-low-density lipoproteins
very-low-density lipoprotein
The active insecticidal constituents of Chrysanthemum cinerariifolium flowers.
CAS:8003-34-7
pyrethrins
calcium cation
A calcium cation that has formula Ca.
Ca(2+)
Ca++
Ca2+
calcium(2+)
calcium ion
A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.
Beilstein:8373630
CAS:134523-00-5
DrugBank:DB01076
Drug_Central:257
LINCS:LSM-5771
PMID:11693468
PMID:15012735
PMID:18720283
Reaxys:8373630
(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Atorvastatin
(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
Atorlip
atorvastatin
atorvastatina
atorvastatine
atorvastatinum
CHEBI:39548
atorvastatin
Beilstein:8373630
Beilstein
CAS:134523-00-5
ChemIDplus
Drug_Central:257
DrugCentral
PMID:11693468
Europe PMC
PMID:15012735
Europe PMC
PMID:18720283
Europe PMC
Reaxys:8373630
Reaxys
An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
CAS:22494-42-4
DrugBank:DB00861
Drug_Central:880
LINCS:LSM-2490
PMID:23144359
PMID:23416065
PMID:28166217
Reaxys:2654431
2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Diflunisal
2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid
2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid
5-(2,4-difluorophenyl)salicylic acid
Dolobid
CHEBI:39669
diflunisal
CAS:22494-42-4
ChemIDplus
CAS:22494-42-4
NIST Chemistry WebBook
Drug_Central:880
DrugCentral
PMID:23144359
Europe PMC
PMID:23416065
Europe PMC
PMID:28166217
Europe PMC
Reaxys:2654431
Reaxys
A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
C8H16O2
CCCC(CCC)C(O)=O
Beilstein:1750447
CAS:99-66-1
DrugBank:DB00313
Drug_Central:2803
LINCS:LSM-4620
LIPID_MAPS_instance:LMFA01020291
PMID:11716839
PMID:12475192
PMID:15124690
PMID:15560954
PMID:15578701
PMID:16496131
PMID:16621443
PMID:16759735
PMID:17156483
PMID:17273758
PMID:19280426
PMID:19318486
PMID:23792104
PMID:23810771
PMID:23949302
PMID:24135375
PMID:24200999
PMID:24348849
PMID:8558327
PMID:8681902
Reaxys:1750447
Wikipedia:Valproic_Acid
2-propylpentanoic acid
VALPROIC ACID
2-PROPYL-PENTANOIC ACID
2-n-propyl-n-valeric acid
2-propylpentanoic acid
2-propylvaleric acid
4-heptanecarboxylic acid
DPA
Depakene
Di-n-propylessigsaeure
VPA
Valproinsaeure
acide valproique
acido valproico
acidum valproicum
di-n-propylacetic acid
dipropylacetic acid
n-DPA
valproic acid
CHEBI:39867
valproic acid
Beilstein:1750447
ChemIDplus
CAS:99-66-1
ChemIDplus
CAS:99-66-1
NIST Chemistry WebBook
Drug_Central:2803
DrugCentral
LIPID_MAPS_instance:LMFA01020291
LIPID MAPS
PMID:11716839
Europe PMC
PMID:12475192
Europe PMC
PMID:15124690
Europe PMC
PMID:15560954
Europe PMC
PMID:15578701
Europe PMC
PMID:16496131
Europe PMC
PMID:16621443
Europe PMC
PMID:16759735
Europe PMC
PMID:17156483
Europe PMC
PMID:17273758
Europe PMC
PMID:19280426
Europe PMC
PMID:19318486
Europe PMC
PMID:23792104
Europe PMC
PMID:23810771
Europe PMC
PMID:23949302
Europe PMC
PMID:24135375
Europe PMC
PMID:24200999
Europe PMC
PMID:24348849
Europe PMC
PMID:8558327
Europe PMC
PMID:8681902
Europe PMC
Reaxys:1750447
Reaxys
A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Beilstein:608611
CAS:315-30-0
DrugBank:DB00437
Drug_Central:124
LINCS:LSM-5919
PMID:11333159
PMID:16650385
PMID:24395556
PMID:24590210
PMID:24591375
PMID:7602118
Reaxys:608611
1H-pyrazolo[3,4-d]pyrimidin-4-ol
Allopurinol
1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one
1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one
1H-Pyrazolo(3,4-d)pyrimidin-4-ol
4'-Hydroxypyrazolol(3,4-d)pyrimidine
4-HPP
4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine
4-Hydroxy-3,4-pyrazolopyrimidine
4-Hydroxypyrazolo(3,4-d)pyrimidine
4-Hydroxypyrazolopyrimidine
4-Hydroxypyrazolyl(3,4-d)pyrimidine
4H-Pyrazolo(3,4-d)pyrimidin-4-one
AL-100
Allopurinolum
Alopurinol
Zyloprim (TN)
CHEBI:40279
allopurinol
Beilstein:608611
Beilstein
CAS:315-30-0
ChemIDplus
CAS:315-30-0
NIST Chemistry WebBook
Drug_Central:124
DrugCentral
PMID:11333159
Europe PMC
PMID:16650385
Europe PMC
PMID:24395556
Europe PMC
PMID:24590210
Europe PMC
PMID:24591375
Europe PMC
PMID:7602118
Europe PMC
Reaxys:608611
Reaxys
A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
C62H111N11O12
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
DrugBank:DB00091
LINCS:LSM-1703
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
cyclosporin A
Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. (by Wikipedia)
C26H29NO
CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
Beilstein:2062020
CAS:10540-29-1
DrugBank:DB00675
Drug_Central:2561
PMID:12612646
PMID:14681337
PMID:14709804
PMID:18348622
PMID:7688593
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
Tamoxifen
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
Apo-Tamox
Crisafeno
Diemon
tamoxifen
tamoxifene
tamoxifeno
tamoxifenum
trans-Tamoxifen
CHEBI:41774
tamoxifen
Beilstein:2062020
Beilstein
CAS:10540-29-1
ChemIDplus
Drug_Central:2561
DrugCentral
PMID:14681337
Europe PMC
PMID:14709804
Europe PMC
PMID:18348622
Europe PMC
PMID:7688593
Europe PMC
A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
Beilstein:7493116
CAS:136470-78-5
DrugBank:DB01048
Drug_Central:34
PMID:11678376
PMID:11806176
PMID:12781181
PMID:15887959
PMID:16458506
PMID:16539393
PMID:16759112
PMID:17172311
PMID:17870541
PMID:18029175
PMID:18549801
PMID:24751900
PMID:25017682
PMID:25674793
PMID:26024233
Reaxys:7493116
Abacavir
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
ABC
abacavir
{(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
CHEBI:421707
abacavir
Beilstein:7493116
Beilstein
CAS:136470-78-5
ChemIDplus
Drug_Central:34
DrugCentral
PMID:11678376
Europe PMC
PMID:11806176
Europe PMC
PMID:12781181
ChEMBL
PMID:15887959
ChEMBL
PMID:16458506
ChEMBL
PMID:16539393
ChEMBL
PMID:16759112
ChEMBL
PMID:17172311
ChEMBL
PMID:17870541
ChEMBL
PMID:18029175
ChEMBL
PMID:18549801
Europe PMC
PMID:24751900
Europe PMC
PMID:25017682
Europe PMC
PMID:25674793
Europe PMC
PMID:26024233
Europe PMC
Reaxys:7493116
Reaxys
An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.
C37H67NO13
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
DrugBank:DB00199
Wikipedia:Erythromycin
erythromycin A
A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Beilstein:521487
CAS:4342-03-4
DrugBank:DB00851
Drug_Central:773
PMID:10751609
PMID:11318431
PMID:12195827
PMID:15010317
PMID:20082117
PMID:21471822
PMID:21654834
PMID:23029050
PMID:23318786
PMID:26940170
PMID:28096700
PMID:28250333
PMID:28387914
PMID:28419676
PMID:29076951
PMID:29184162
PMID:29287706
PMID:29296081
PMID:29305638
PMID:29344241
Reaxys:521487
5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide
4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(dimethyltriazeno)imidazole-5-carboxamide
5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide
5-(3,3-dimethyltriazeno)imidazole-4-carboxamide
5-(dimethyltriazeno)imidazole-4-carboxamide
DIC
DTIC
Di-me-triazenoimidazolecarboxamide
Dtic-Dome (TN)
HSDB 3219
ICDMT
Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-
NCI-C04717
NSC 45388
NSC-45388
dacarbazina
dacarbazine
dacarbazinum
deticene
CHEBI:4305
dacarbazine
Beilstein:521487
Beilstein
CAS:4342-03-4
ChemIDplus
CAS:4342-03-4
NIST Chemistry WebBook
Drug_Central:773
DrugCentral
PMID:10751609
Europe PMC
PMID:11318431
Europe PMC
PMID:12195827
Europe PMC
PMID:15010317
Europe PMC
PMID:20082117
Europe PMC
PMID:21471822
Europe PMC
PMID:21654834
Europe PMC
PMID:23029050
Europe PMC
PMID:23318786
Europe PMC
PMID:26940170
Europe PMC
PMID:28096700
Europe PMC
PMID:28250333
Europe PMC
PMID:28387914
Europe PMC
PMID:28419676
Europe PMC
PMID:29076951
Europe PMC
PMID:29184162
Europe PMC
PMID:29287706
Europe PMC
PMID:29296081
Europe PMC
PMID:29305638
Europe PMC
PMID:29344241
Europe PMC
Reaxys:521487
Reaxys
Beilstein:4851114
CAS:17230-88-5
DrugBank:DB01406
Drug_Central:779
PMID:17929794
PMID:18834112
[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
Cyclomen
Danocrine
danazol
danazolum
CHEBI:4315
danazol
Beilstein:4851114
Beilstein
CAS:17230-88-5
ChemIDplus
Drug_Central:779
DrugCentral
PMID:17929794
ChEMBL
PMID:18834112
ChEMBL
The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
Beilstein:705189
CAS:7261-97-4
DrugBank:DB01219
LINCS:LSM-3823
1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
Dantrolene
1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin
dantrolene
dantroleno
dantrolenum
CHEBI:4317
dantrolene
Beilstein:705189
Beilstein
CAS:7261-97-4
ChemIDplus
CAS:150378-17-9
DrugBank:DB00224
Drug_Central:1437
LINCS:LSM-5471
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
2-benzyl-5-[(2S)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethyl)piperazin-1-yl]-2,3,5-trideoxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-D-erythro-pentonamide
Indinavir
(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-Pentonamide
CHEBI:44032
indinavir
CAS:150378-17-9
ChemIDplus
Drug_Central:1437
DrugCentral
Beilstein:70669
CAS:59-05-2
DrugBank:DB00563
Drug_Central:1751
LINCS:LSM-5690
METHOTREXATE
Methotrexate
N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Emtexate
Ledertrexate
MTX
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
methotrexate
methotrexatum
metotrexato
CHEBI:44185
methotrexate
Beilstein:70669
Beilstein
CAS:59-05-2
ChemIDplus
CAS:59-05-2
NIST Chemistry WebBook
Drug_Central:1751
DrugCentral
A mucopolysaccharide consisting of repeating beta-(1->4)-linked L-iduronyl-(beta1->3)-N-acetyl-D-galactosamine units.
Dermatan
Dermatan L-iduronate
CHEBI:4439
dermatan
A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Beilstein:1741548
CAS:127-07-1
DrugBank:DB01005
Drug_Central:1399
Gmelin:130423
PMID:11285159
PMID:11298103
PMID:11364534
PMID:11365149
PMID:11391710
PMID:12107454
PMID:14988684
PMID:15772364
PMID:15994344
PMID:16356682
PMID:22983419
PMID:23318979
PMID:23643402
PMID:23696560
PMID:9271088
Reaxys:1741548
Hydroxyurea
N-hydroxyurea
hydroxyurea
Hydroxycarbamid
Hydroxycarbamide
Hydroxyharnstoff
N-HYDROXYUREA
N-carbamoylhydroxylamine
carbamohydroxamic acid
carbamohydroximic acid
carbamoyl oxime
carbamyl hydroxamate
hidroxicarbamida
hydrea
hydroxycarbamide
hydroxycarbamidum
oxyurea
CHEBI:44423
hydroxyurea
Beilstein:1741548
ChemIDplus
CAS:127-07-1
ChemIDplus
Drug_Central:1399
DrugCentral
Gmelin:130423
Gmelin
PMID:11285159
Europe PMC
PMID:11298103
Europe PMC
PMID:11364534
Europe PMC
PMID:11365149
Europe PMC
PMID:11391710
Europe PMC
PMID:12107454
Europe PMC
PMID:14988684
Europe PMC
PMID:15772364
Europe PMC
PMID:15994344
Europe PMC
PMID:16356682
Europe PMC
PMID:22983419
Europe PMC
PMID:23318979
Europe PMC
PMID:23643402
Europe PMC
PMID:23696560
Europe PMC
PMID:9271088
Europe PMC
Reaxys:1741548
Reaxys
An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
C13H12N2O5S
CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
Beilstein:2421175
CAS:51803-78-2
DrugBank:DB04743
Drug_Central:1935
LINCS:LSM-3718
PMID:18426087
Reaxys:2421175
N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
Nimesulide
4'-nitro-2'-phenoxymethanesulfonanilide
4-NITRO-2-PHENOXYMETHANESULFONANILIDE
CHEBI:44445
nimesulide
Beilstein:2421175
Beilstein
CAS:51803-78-2
ChemIDplus
Drug_Central:1935
DrugCentral
PMID:18426087
Europe PMC
Reaxys:2421175
Reaxys
CAS:61379-65-5
DrugBank:DB01201
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate
Rifapentine
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
Cyclopentylrifampicin
Priftin (TN)
CHEBI:45304
rifapentine
CAS:61379-65-5
ChemIDplus
An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
CAS:155213-67-5
Drug_Central:2391
LINCS:LSM-5623
PMID:11363086
PMID:11363184
PMID:11363300
PMID:11363329
PMID:11363397
PMID:11363517
PMID:11996889
PMID:24202050
PMID:8568292
PMID:9140265
PMID:9278209
PMID:9585800
Reaxys:768009
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
ritonavir
CHEBI:45409
ritonavir
CAS:155213-67-5
ChemIDplus
Drug_Central:2391
DrugCentral
PMID:11363086
Europe PMC
PMID:11363184
Europe PMC
PMID:11363300
Europe PMC
PMID:11363329
Europe PMC
PMID:11363397
Europe PMC
PMID:11363517
Europe PMC
PMID:11996889
Europe PMC
PMID:24202050
Europe PMC
PMID:8568292
Europe PMC
PMID:9140265
Europe PMC
PMID:9278209
Europe PMC
PMID:9585800
Europe PMC
Reaxys:768009
Reaxys
A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.
Beilstein:7671333
CAS:152459-95-5
DrugBank:DB00619
Drug_Central:1423
LINCS:LSM-1023
PMID:14660054
PMID:14715630
PMID:15073101
PMID:15170967
PMID:15722647
PMID:15794712
PMID:15966213
PMID:16122278
PMID:16826359
PMID:16983347
PMID:17190842
PMID:17410337
PMID:17457302
PMID:17717205
PMID:18193246
PMID:18216472
PMID:18337118
PMID:18344535
PMID:18376233
PMID:18407734
PMID:18420270
PMID:18423008
PMID:18548219
PMID:18623899
PMID:18780518
PMID:18809244
PMID:19020005
PMID:19052981
PMID:19077095
PMID:19097599
PMID:19182535
PMID:19242505
PMID:19415889
PMID:19527930
PMID:19591692
PMID:19693287
PMID:19749465
PMID:19810774
PMID:19853594
PMID:19920908
PMID:22891806
PMID:23075630
PMID:23183914
PMID:23313020
PMID:23394269
PMID:23480638
PMID:23503753
PMID:23536338
PMID:23574742
PMID:23580311
PMID:23587588
Reaxys:7671333
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
STI 571
alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
imatinib
CHEBI:45783
imatinib
Beilstein:7671333
Beilstein
CAS:152459-95-5
ChemIDplus
Drug_Central:1423
DrugCentral
PMID:14660054
Europe PMC
PMID:14715630
Europe PMC
PMID:15073101
Europe PMC
PMID:15170967
Europe PMC
PMID:15722647
Europe PMC
PMID:15794712
Europe PMC
PMID:15966213
Europe PMC
PMID:16122278
Europe PMC
PMID:16826359
Europe PMC
PMID:16983347
Europe PMC
PMID:17190842
Europe PMC
PMID:17410337
Europe PMC
PMID:17457302
Europe PMC
PMID:17717205
Europe PMC
PMID:18193246
Europe PMC
PMID:18216472
Europe PMC
PMID:18337118
Europe PMC
PMID:18344535
Europe PMC
PMID:18376233
Europe PMC
PMID:18407734
Europe PMC
PMID:18420270
Europe PMC
PMID:18423008
Europe PMC
PMID:18548219
Europe PMC
PMID:18623899
Europe PMC
PMID:18780518
Europe PMC
PMID:18809244
Europe PMC
PMID:19020005
Europe PMC
PMID:19052981
Europe PMC
PMID:19077095
Europe PMC
PMID:19097599
Europe PMC
PMID:19182535
Europe PMC
PMID:19242505
Europe PMC
PMID:19415889
Europe PMC
PMID:19527930
Europe PMC
PMID:19591692
Europe PMC
PMID:19693287
Europe PMC
PMID:19749465
Europe PMC
PMID:19810774
Europe PMC
PMID:19853594
Europe PMC
PMID:19920908
Europe PMC
PMID:22891806
Europe PMC
PMID:23075630
Europe PMC
PMID:23183914
Europe PMC
PMID:23313020
Europe PMC
PMID:23394269
Europe PMC
PMID:23480638
Europe PMC
PMID:23503753
Europe PMC
PMID:23536338
Europe PMC
PMID:23574742
Europe PMC
PMID:23580311
Europe PMC
PMID:23587588
Europe PMC
Reaxys:7671333
Reaxys
A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.
Beilstein:611403
CAS:148-79-8
DrugBank:DB00730
Drug_Central:2621
LINCS:LSM-3741
PMID:11226373
PMID:13900465
PMID:23790859
PMID:9009055
Pesticides:thiabendazole
Reaxys:611403
2-(1,3-thiazol-4-yl)-1H-benzimidazole
Thiabendazole
2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE
2-(1,3-thiazol-4-yl)benzimidazole
2-(4-thiazolyl)-1H-benzimidazole
2-(thiazol-4-yl)benzimidazole
4-(2-benzimidazolyl)thiazole
Equizole
MK 360
Mintezol
TBZ
Thibenzole
Tiabendazole
CHEBI:45979
thiabendazole
Beilstein:611403
Beilstein
CAS:148-79-8
ChemIDplus
CAS:148-79-8
NIST Chemistry WebBook
Drug_Central:2621
DrugCentral
PMID:11226373
Europe PMC
PMID:13900465
Europe PMC
PMID:23790859
Europe PMC
PMID:9009055
Europe PMC
Pesticides:thiabendazole
Alan Wood's Pesticides
Reaxys:611403
Reaxys
A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
C13H14N2
Nc1c2CCCCc2nc2ccccc12
CAS:321-64-2
DrugBank:DB00382
Wikipedia:Tacrine
1,2,3,4-tetrahydroacridin-9-amine
tacrine
A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Beilstein:4269710
CAS:86386-73-4
DrugBank:DB00196
Drug_Central:1187
LINCS:LSM-2106
PMID:11366931
PMID:16822276
PMID:23171950
PMID:23793863
Reaxys:7311650
2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol
fluconazole
2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Biozole
Diflucan
Elazor
Triflucan
fluconazol
fluconazole
fluconazolum
CHEBI:46081
fluconazole
Beilstein:4269710
Beilstein
CAS:86386-73-4
ChemIDplus
Drug_Central:1187
DrugCentral
PMID:11366931
Europe PMC
PMID:16822276
Europe PMC
PMID:23171950
Europe PMC
PMID:23793863
Europe PMC
Reaxys:7311650
Reaxys
A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
C8H9NO2
CC(=O)Nc1ccc(O)cc1
CAS:103-90-2
DrugBank:DB00316
Wikipedia:Acetaminophen
Wikipedia:Paracetamol
N-(4-hydroxyphenyl)acetamide
APAP
Acetaminophen
paracetamol
An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
C10H20N2S4
S(SC(N(CC)CC)=S)C(N(CC)CC)=S
CAS:97-77-8
DrugBank:DB00822
Drug_Central:928
LINCS:LSM-5467
PMID:10841824
PMID:11005259
PMID:11716515
PMID:14978246
PMID:15325261
PMID:15709459
PMID:16426571
PMID:16661923
PMID:16666414
PMID:16880974
PMID:17079463
PMID:17579916
PMID:17667894
PMID:18579431
PMID:19720750
PMID:19782464
PMID:19787200
PMID:21471244
PMID:24496638
PMID:25133664
PMID:25445071
PMID:25464072
PMID:25476326
PMID:25495604
PMID:25557293
PMID:25565438
PMID:25657800
PMID:25777347
PMID:26033731
PMID:26224731
PMID:26235918
PMID:26239994
PMID:26314552
PMID:26517513
PMID:26550292
PMID:8442800
PMID:8572926
Reaxys:1712560
Wikipedia:Disulfiram
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
Disulfiram
1,1'-dithiobis(N,N-diethylthioformamide)
Antabuse
N,N,N',N'-tetraethylthiuram disulfide
Tetraethylthiuram disulfide
bis(diethylthiocarbamoyl) disulfide
tetraethylthioperoxydicarbonic diamide
tetraethylthiuram disulfide
tetraethylthiuram disulphide
CHEBI:4659
disulfiram
CAS:97-77-8
ChemIDplus
CAS:97-77-8
NIST Chemistry WebBook
Drug_Central:928
DrugCentral
PMID:10841824
Europe PMC
PMID:11005259
Europe PMC
PMID:11716515
Europe PMC
PMID:14978246
Europe PMC
PMID:15325261
Europe PMC
PMID:15709459
Europe PMC
PMID:16426571
Europe PMC
PMID:16661923
Europe PMC
PMID:16666414
Europe PMC
PMID:16880974
Europe PMC
PMID:17079463
Europe PMC
PMID:17579916
Europe PMC
PMID:17667894
Europe PMC
PMID:18579431
Europe PMC
PMID:19720750
Europe PMC
PMID:19782464
Europe PMC
PMID:19787200
Europe PMC
PMID:21471244
Europe PMC
PMID:24496638
Europe PMC
PMID:25133664
Europe PMC
PMID:25445071
Europe PMC
PMID:25464072
Europe PMC
PMID:25476326
Europe PMC
PMID:25495604
Europe PMC
PMID:25557293
Europe PMC
PMID:25565438
Europe PMC
PMID:25657800
Europe PMC
PMID:25777347
Europe PMC
PMID:26033731
Europe PMC
PMID:26224731
Europe PMC
PMID:26235918
Europe PMC
PMID:26239994
Europe PMC
PMID:26314552
Europe PMC
PMID:26517513
Europe PMC
PMID:26550292
Europe PMC
PMID:8442800
Europe PMC
PMID:8572926
Europe PMC
Reaxys:1712560
Reaxys
A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
Wikipedia:Solvent
solvent
A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
C14H11Cl2NO2
C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl
ATC:D11AX18
ATC:M01AB05
ATC:M02AA15
ATC:S01BC03
Beilstein:2146636
CAS:15307-86-5
DrugBank:DB00586
Drug_Central:865
LINCS:LSM-2160
PMID:11322639
PMID:1502708
PMID:23777257
PMID:27967303
PMID:7838674
Reaxys:2146636
Wikipedia:Diclofenac
2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
Diclofenac
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
2-((2,6-dichlorophenyl)amino)benzeneacetic acid
[2-(2,6-dichloroanilino)phenyl]acetic acid
diclofenac
diclofenac acid
diclofenaco
diclofenacum
diclofenamic acid
CHEBI:47381
diclofenac
Beilstein:2146636
Beilstein
CAS:15307-86-5
ChemIDplus
CAS:15307-86-5
NIST Chemistry WebBook
Drug_Central:865
DrugCentral
PMID:11322639
Europe PMC
PMID:1502708
Europe PMC
PMID:23777257
Europe PMC
PMID:27967303
Europe PMC
PMID:7838674
Europe PMC
Reaxys:2146636
Reaxys
A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
Beilstein:8471798
CAS:162808-62-0
DrugBank:DB00520
Drug_Central:2977
PMID:24270605
(10R,12S)-N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
Caspofungin
(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide
1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0
caspofungin
CHEBI:474180
caspofungin
Beilstein:8471798
Beilstein
CAS:162808-62-0
ChemIDplus
Drug_Central:2977
DrugCentral
PMID:24270605
Europe PMC
Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
C19H24N2
CN(C)CCCN1c2ccccc2CCc2ccccc12
DrugBank:DB00458
Open TG-Gates compound_id:00069
Wikipedia:Imipramine
https://livertox.nlm.nih.gov//Imipramine.htm
imipramine
A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Beilstein:4303081
CAS:65277-42-1
DrugBank:DB01026
Gmelin:1713206
Open TG-Gates compound_id=00047
rac-1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
Fungarest
Fungoral
Ketoderm
Ketoisdin
Nizoral
Panfungol
Xolegel
cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
ketoconazol
ketoconazole
ketoconazolum
CHEBI:47519
ketoconazole
Beilstein:4303081
ChemIDplus
CAS:65277-42-1
ChemIDplus
Gmelin:1713206
Gmelin
A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
C19H23ClN2
Beilstein:1323477
CAS:303-49-1
CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
DrugBank:DB01242
Drug_Central:701
LINCS:LSM-3171
Open TG-Gates compound_id:00121
PMID:12007764
PMID:12084414
PMID:16085036
PMID:17471183
PMID:19747949
PMID:19810911
Patent:US3467650
Reaxys:1323477
3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Clomipramine
3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
3-chloroimipramine
G 34586
chlorimipramine
monochlorimipramine
CHEBI:47780
clomipramine
Beilstein:1323477
ChemIDplus
CAS:303-49-1
ChemIDplus
CAS:303-49-1
NIST Chemistry WebBook
Drug_Central:701
DrugCentral
PMID:12007764
Europe PMC
PMID:12084414
Europe PMC
PMID:16085036
Europe PMC
PMID:17471183
Europe PMC
PMID:19747949
Europe PMC
PMID:19810911
Europe PMC
Reaxys:1323477
Reaxys
A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
photosensitising agent
CHEBI:47868
photosensitizing agent
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
protein synthesis antagonist
protein synthesis antagonists
protein synthesis inhibitors
CHEBI:48001
protein synthesis inhibitor
serotonergic agents
serotonergic drugs
serotonin drugs
CHEBI:48278
serotonergic drug
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
5-HT antagonists
5-hydroxytryptamine antagonists
antiserotonergic agents
serotonin antagonists
serotonin blockaders
CHEBI:48279
serotonergic antagonist
An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).
COMT inhibitor
COMT inhibitors
EC 2.1.1.6 (catechol O-methyltransferase) inhibitors
EC 2.1.1.6 inhibitor
EC 2.1.1.6 inhibitors
S-adenosyl-L-methionine:catechol O-methyltransferase inhibitor
S-adenosyl-L-methionine:catechol O-methyltransferase inhibitors
catechol O-methyltransferase (EC 2.1.1.6) inhibitor
catechol O-methyltransferase (EC 2.1.1.6) inhibitors
catechol O-methyltransferase inhibitor
catechol O-methyltransferase inhibitors
catechol methyltransferase inhibitor
catechol methyltransferase inhibitors
catecholamine O-methyltransferase inhibitor
catecholamine O-methyltransferase inhibitors
CHEBI:48406
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
A drug used in the treatment of Parkinson's disease.
Wikipedia:Antiparkinson
antiparkinson agent
CHEBI:48407
antiparkinson drug
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
angiogenesis antagonist
angiostatic agents
anti-angiogenic agent
CHEBI:48422
angiogenesis inhibitor
C40H71NO14.C12H26O4S
CCCCCCCCCCCCOS(O)(=O)=O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
erythromycin estolate
Any drug that acts on an alpha-adrenergic receptor.
alpha-adrenergic drugs
CHEBI:48539
alpha-adrenergic drug
Any of the drugs that act on beta-adrenergic receptors.
beta-adrenergic drugs
CHEBI:48540
beta-adrenergic drug
Beilstein:4208277
CAS:82964-04-3
DrugBank:DB02383
Drug_Central:2704
N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbonothioyl}-N-methylglycine
TOLRESTAT
Tolrestat
Alredase
N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methylglycine
N-{[6-methoxy-5-(trifluoromethyl)-1-naphthyl]carbonothioyl}-N-methylglycine
tolrestat
tolrestatum
CHEBI:48549
tolrestat
Beilstein:4208277
Beilstein
CAS:82964-04-3
ChemIDplus
Drug_Central:2704
DrugCentral
An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
ALR2 inhibitor
ALR2 inhibitors
EC 1.1.1.21 (aldehyde reductase) inhibitors
EC 1.1.1.21 inhibitor
EC 1.1.1.21 inhibitors
NADPH-aldopentose reductase inhibitor
NADPH-aldopentose reductase inhibitors
NADPH-aldose reductase inhibitor
NADPH-aldose reductase inhibitors
aldehyde reductase (EC 1.1.1.21) inhibitor
aldehyde reductase (EC 1.1.1.21) inhibitors
aldehyde reductase inhibitor
aldehyde reductase inhibitors
alditol:NAD(P)(+) 1-oxidoreductase inhibitor
alditol:NAD(P)(+) 1-oxidoreductase inhibitors
alditol:NADP oxidoreductase inhibitor
alditol:NADP oxidoreductase inhibitors
alditol:NADP(+) 1-oxidoreductase inhibitor
alditol:NADP(+) 1-oxidoreductase inhibitors
aldose reductase inhibitor
aldose reductase inhibitors
polyol dehydrogenase (NADP(+)) inhibitor
polyol dehydrogenase (NADP(+)) inhibitors
CHEBI:48550
EC 1.1.1.21 (aldehyde reductase) inhibitor
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
dopamine agent
dopamine agents
dopamine drug
dopamine drugs
dopaminergic agents
CHEBI:48560
dopaminergic agent
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
dopamine antagonist
dopamine blocker
dopamine receptor antagonist
dopaminergic antagonists
CHEBI:48561
dopaminergic antagonist
A role played by a substance that can react readily with, and thereby eliminate, radicals.
free radical scavenger
free radical scavengers
free-radical scavenger
CHEBI:48578
radical scavenger
A drug that affects the function of fibrin in blood coagulation.
fibrin modulating agent
fibrin modulating agents
fibrin modulating drugs
CHEBI:48676
fibrin modulating drug
A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
Beilstein:5637599
CAS:2998-57-4
DrugBank:DB01196
Drug_Central:1065
LIPID_MAPS_instance:LMST02010038
PMID:11131983
PMID:15762353
PMID:7638085
Reaxys:5637599
(17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate
Estramustine
17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)
Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)
estramustina
estramustine
estramustinum
CHEBI:4868
estramustine
Beilstein:5637599
Beilstein
CAS:2998-57-4
ChemIDplus
Drug_Central:1065
DrugCentral
LIPID_MAPS_instance:LMST02010038
LIPID MAPS
PMID:11131983
Europe PMC
PMID:15762353
Europe PMC
PMID:7638085
Europe PMC
Reaxys:5637599
Reaxys
Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
agonist
agonista
agoniste
agonists
CHEBI:48705
agonist
Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
antagonist
antagonista
antagoniste
antagonists
CHEBI:48706
antagonist
An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.
Beilstein:6312870
CAS:74-55-5
DrugBank:DB00330
Drug_Central:1073
PMID:10649975
PMID:10891117
PMID:10966749
PMID:12182855
PMID:14695841
PMID:14698152
PMID:15225698
PMID:16005211
PMID:16759086
PMID:16870429
PMID:17210775
PMID:17239593
PMID:17276683
PMID:17315960
PMID:17331717
PMID:17562368
PMID:17851083
PMID:17888665
PMID:19524332
PMID:19648006
PMID:3934384
Reaxys:6312870
(2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
Ethambutol
(+)-2,2'-(ethylenediimino)di-1-butanol
(+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine
(+)-S,S-ethambutol
(+)-ethambutol
(2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol
(S,S)-ethambutol
EMB
S,S-Ethambutol
etambutol
ethambutol
ethambutolum
CHEBI:4877
ethambutol
Beilstein:6312870
Beilstein
CAS:74-55-5
ChemIDplus
Drug_Central:1073
DrugCentral
PMID:10649975
ChEMBL
PMID:10891117
ChEMBL
PMID:10966749
ChEMBL
PMID:12182855
ChEMBL
PMID:14695841
ChEMBL
PMID:14698152
ChEMBL
PMID:15225698
ChEMBL
PMID:16005211
ChEMBL
PMID:16759086
ChEMBL
PMID:16870429
ChEMBL
PMID:17210775
ChEMBL
PMID:17239593
ChEMBL
PMID:17276683
ChEMBL
PMID:17315960
ChEMBL
PMID:17331717
ChEMBL
PMID:17562368
ChEMBL
PMID:17851083
ChEMBL
PMID:17888665
ChEMBL
PMID:19524332
ChEMBL
PMID:19648006
ChEMBL
PMID:3934384
ChEMBL
Reaxys:6312870
Reaxys
A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.
C8H10N2S
CCc1cc(ccn1)C(N)=S
CAS:536-33-4
DrugBank:DB00609
Wikipedia:Ethionamide
2-ethylpyridine-4-carbothioamide
ethionamide
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
Anticholinergika
Anticholinergikum
acetylcholine antagonists
acetylcholine receptor antagonist
agent anticholinergique
agente anticolinergico
agentes anticolinergicos
anticholinergic agents
anticholinergics
anticholinergiques
anticolinergicos
cholinergic-blocking agents
CHEBI:48873
cholinergic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
Antimuskarinika
Antimuskarinikum
agente antimuscarinico
agentes antimuscarinicos
agents antimuscariniques
antimuscarinic agents
antimuscarinicos
muscarinic acetylcholine receptor antagonist
muscarinic antagonists
CHEBI:48876
muscarinic antagonist
Metabolites of bile acids, four-ringed steroid acids formed along the cholesterol degradation pathway.
bile acid metabolite
Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).
DrugBank:DB00199
eritromicina
erthromycin
erythromycine
CHEBI:48923
erythromycin
A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.
Beilstein:8442898
CAS:201530-41-8
DrugBank:DB01609
Drug_Central:3128
Reaxys:8442898
4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
Exjade
ICL 670
ICL 670A
deferasirox
deferasiroxum
CHEBI:49005
deferasirox
Beilstein:8442898
Beilstein
CAS:201530-41-8
ChemIDplus
Drug_Central:3128
DrugCentral
Reaxys:8442898
Reaxys
A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
hormone antagonists
CHEBI:49020
hormone antagonist
A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.
C10H12N4O3
OC[C@@H]1CC[C@@H](O1)n1cnc2c1nc[nH]c2=O
Beilstein:3619529
CAS:69655-05-6
DrugBank:DB00900
Drug_Central:869
LINCS:LSM-6017
PMID:10386939
PMID:1619614
PMID:17046264
PMID:18549801
PMID:29438107
Reaxys:3619529
Wikipedia:Didanosine
2',3'-dideoxyinosine
Didanosine
ddI
2,3-dideoxyinosine
9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol
9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
DDI
ddI
ddIno
didanosina
didanosine
didanosinum
dideoxyinosine
CHEBI:490877
didanosine
Beilstein:3619529
Beilstein
CAS:69655-05-6
ChemIDplus
Drug_Central:869
DrugCentral
PMID:10386939
ChEMBL
PMID:1619614
ChEMBL
PMID:17046264
ChEMBL
PMID:18549801
Europe PMC
PMID:29438107
Europe PMC
Reaxys:3619529
Reaxys
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
CAS:41340-25-4
DrugBank:DB00749
Drug_Central:1103
LINCS:LSM-1781
PMID:15369391
PMID:2527995
PMID:28166217
PMID:2970548
(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
ETODOLAC
(+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
(1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
ETODOLIC ACID
etodolac
etodolaco
etodolacum
CHEBI:4909
etodolac
CAS:41340-25-4
ChemIDplus
Drug_Central:1103
DrugCentral
PMID:15369391
ChEMBL
PMID:2527995
ChEMBL
PMID:28166217
Europe PMC
PMID:2970548
ChEMBL
Any human metabolite produced by metabolism of drugs in humans.
drug metabolites
CHEBI:49103
drug metabolite
A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
LTRA
leukotriene antagonists
leukotriene receptor antagonist
leukotriene receptor antagonists
CHEBI:49159
leukotriene antagonist
A drug used to treat asthma.
anti-asthmatic agent
anti-asthmatic agents
anti-asthmatic drugs
CHEBI:49167
anti-asthmatic drug
One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
anti-ulcer agent
anti-ulcer drug
A chemical substance that prevents or reduces the probability of conception.
contraceptive agent
contraceptive drugs
CHEBI:49323
contraceptive drug
A chemical substance or agent with contraceptive activity in females.
female contraceptive agent
female contraceptive drugs
CHEBI:49324
female contraceptive drug
A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
CAS:107868-30-4
DrugBank:DB00990
Drug_Central:1122
PMID:10882163
Reaxys:6609645
6-methylideneandrosta-1,4-diene-3,17-dione
Exemestane
6-methyleneandrosta-1,4-diene-3,17-dione
exemestane
exemestano
exemestanum
CHEBI:4953
exemestane
CAS:107868-30-4
ChemIDplus
Drug_Central:1122
DrugCentral
PMID:10882163
Europe PMC
Reaxys:6609645
Reaxys
Beilstein:10502247
CAS:231277-92-2
DrugBank:DB01259
Drug_Central:1548
LINCS:LSM-1051
N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
GW 572016
N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
Tykerb
CHEBI:49603
lapatinib
Beilstein:10502247
Beilstein
CAS:231277-92-2
ChemIDplus
Drug_Central:1548
DrugCentral
Inchikey:YZCKVEUIGOORGS-UHFFFAOYSA-N
hydrogen
hydrogen atom
A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.
CAS:184475-35-2
DrugBank:DB00317
Drug_Central:1282
LINCS:LSM-1098
PMID:14981586
PMID:15068398
PMID:20573926
PMID:20949670
PMID:27396387
PMID:28968167
PMID:29332330
PMID:29493460
PMID:29579334
PMID:29668619
PMID:30068310
PMID:30069771
PMID:30214852
Reaxys:8949523
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
Iressa
Irressat
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine
ZD 1839
ZD-1839
ZD1839
gefitinib
gefitinibum
CHEBI:49668
gefitinib
CAS:184475-35-2
ChemIDplus
Drug_Central:1282
DrugCentral
PMID:14981586
Europe PMC
PMID:15068398
Europe PMC
PMID:20573926
Europe PMC
PMID:20949670
Europe PMC
PMID:27396387
Europe PMC
PMID:28968167
Europe PMC
PMID:29332330
Europe PMC
PMID:29493460
Europe PMC
PMID:29579334
Europe PMC
PMID:29668619
Europe PMC
PMID:30068310
Europe PMC
PMID:30069771
Europe PMC
PMID:30214852
Europe PMC
Reaxys:8949523
Reaxys
The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
CAS:25451-15-4
DrugBank:DB00949
Drug_Central:1140
LINCS:LSM-4232
PMID:12825948
PMID:12873507
PMID:18311896
Reaxys:3345236
2-phenylpropane-1,3-diyl dicarbamate
Felbamate
2-phenyl-1,3-propanediol dicarbamate
Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester
carbamic acid 2-phenyltrimethylene ester
felbamate
felbamato
felbamatum
CHEBI:4995
felbamate
CAS:25451-15-4
ChemIDplus
CAS:25451-15-4
NIST Chemistry WebBook
Drug_Central:1140
DrugCentral
PMID:12825948
ChEMBL
PMID:12873507
ChEMBL
PMID:18311896
ChEMBL
Reaxys:3345236
Reaxys
A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c1ccc(Cl)cc1
LINCS:LSM-3107
propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
fenofibrate
A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
CAS:31879-05-7
DrugBank:DB00573
Drug_Central:1154
PMID:21328296
PMID:21342694
PMID:25554116
PMID:28166217
PMID:30168706
PMID:4616811
Reaxys:2118687
2-(3-phenoxyphenyl)propanoic acid
FENOPROFEN
Fenoprofen
(+-)-2-(3-phenoxyphenyl)propionic acid
(+-)-m-phenoxyhydratropic acid
2-(3-phenoxyphenyl)propionic acid
2-(m-phenoxyphenyl)propionic acid
alpha-(m-phenoxyphenyl)propionic acid
alpha-methyl-3-phenoxybenzeneacetic acid
fenoprofen
fenoprofene
fenoprofeno
fenoprofenum
CHEBI:5004
fenoprofen
CAS:31879-05-7
ChemIDplus
CAS:31879-05-7
NIST Chemistry WebBook
Drug_Central:1154
DrugCentral
PMID:21328296
Europe PMC
PMID:21342694
Europe PMC
PMID:25554116
Europe PMC
PMID:28166217
Europe PMC
PMID:30168706
Europe PMC
PMID:4616811
Europe PMC
Reaxys:2118687
Reaxys
Any hormone that is responsible for controlling sexual characteristics and reproductive function.
Geschlechtshormon
Geschlechtshormone
Sexualhormon
Sexualhormone
hormone sexuelle
hormones sexuelles
sex hormones
CHEBI:50112
sex hormone
A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
Androgen
Androgene
androgene
androgenes
androgeno
androgenos
androgens
CHEBI:50113
androgen
A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
Wikipedia:Estrogen
estrogen
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
CAS:122320-73-4
DrugBank:DB00412
Wikipedia:Rosiglitazone
5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
LINCS:LSM-1949
rosiglitazone
A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.
CAS:54757-46-9
LINCS:LSM-5713
Reaxys:15057225
9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
CHEBI:50172
acitretin
CAS:54757-46-9
ChemIDplus
Reaxys:15057225
Reaxys
A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
desquamating agent
keratolytic agent
keratolytic drugs
skin-peeling agent
CHEBI:50176
keratolytic drug
A drug used to treat or prevent skin disorders or for the routine care of skin.
dermatologic agent
dermatologic drugs
dermatological agent
CHEBI:50177
dermatologic drug
An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
CYP2D6 inhbitor
CYP2D6 inhbitors
P450 inhibitors
cytochrome P450 inhibitor
cytochrome P450 inhibitors
CHEBI:50183
P450 inhibitor
Any pathway inhibitor that inhibits the synthesis of fatty acids.
fatty acid synthesis inhibitor
Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.
hematologic agents
CHEBI:50248
hematologic agent
An agent that prevents blood clotting.
anticoagulante
anticoagulants
CHEBI:50249
anticoagulant
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
PMID:23993918
PMID:23998799
PMID:24329110
PMID:24628402
PMID:24709544
PMID:25144792
PMID:25157234
PMID:25269430
PMID:25391982
PMID:25591121
PMID:25620096
PMID:25795057
PMID:26028253
PMID:26184144
PMID:28070577
PMID:28215138
PMID:28219047
PMID:28259775
PMID:28319647
PMID:28329729
PMID:28334528
Prodrugs
CHEBI:50266
prodrug
PMID:23993918
Europe PMC
PMID:23998799
Europe PMC
PMID:24329110
Europe PMC
PMID:24628402
Europe PMC
PMID:24709544
Europe PMC
PMID:25144792
Europe PMC
PMID:25157234
Europe PMC
PMID:25269430
Europe PMC
PMID:25391982
Europe PMC
PMID:25591121
Europe PMC
PMID:25620096
Europe PMC
PMID:25795057
Europe PMC
PMID:26028253
Europe PMC
PMID:26184144
Europe PMC
PMID:28070577
Europe PMC
PMID:28215138
Europe PMC
PMID:28219047
Europe PMC
PMID:28259775
Europe PMC
PMID:28319647
Europe PMC
PMID:28329729
Europe PMC
PMID:28334528
Europe PMC
Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
chemoprotectant
chemoprotectants
chemoprotective agent
chemoprotective agents
protective agents
CHEBI:50267
protective agent
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
DNA topoisomerase inhibitor
DNA topoisomerase inhibitors
EC 5.99.1.2 (DNA topoisomerase) inhibitors
EC 5.99.1.2 (topoisomerase I) inhibitor
EC 5.99.1.2 (topoisomerase I) inhibitors
EC 5.99.1.2 inhibitor
EC 5.99.1.2 inhibitors
topoisomerase I (EC 5.99.1.2) inhibitor
topoisomerase I (EC 5.99.1.2) inhibitors
topoisomerase I inhibitor
topoisomerase I inhibitors
type I DNA topoisomerase inhibitor
type I DNA topoisomerase inhibitors
CHEBI:50276
EC 5.99.1.2 (DNA topoisomerase) inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
platelet aggregation inhibitors
CHEBI:50427
platelet aggregation inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
EC 3.1.1.4 (phospholipase A2) inhibitor
phospholipase A2 inhibitor
An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
7,8-dihydropteroate synthase inhibitor
7,8-dihydropteroate synthase inhibitors
7,8-dihydropteroate synthetase inhibitor
7,8-dihydropteroate synthetase inhibitors
7,8-dihydropteroic acid synthetase inhibitor
7,8-dihydropteroic acid synthetase inhibitors
DHPS inhibitor
DHPS inhibitors
EC 2.5.1.15 (dihydropteroate synthase) inhibitors
EC 2.5.1.15 inhibitor
EC 2.5.1.15 inhibitors
dihydropteroate diphosphorylase inhibitor
dihydropteroate diphosphorylase inhibitors
dihydropteroate pyrophosphorylase inhibitor
dihydropteroate pyrophosphorylase inhibitors
dihydropteroate synthase (EC 2.5.1.15) inhibitor
dihydropteroate synthase (EC 2.5.1.15) inhibitors
dihydropteroate synthase inhibitor
dihydropteroate synthase inhibitors
dihydropteroate synthetase inhibitor
dihydropteroate synthetase inhibitors
dihydropteroic synthetase inhibitor
dihydropteroic synthetase inhibitors
CHEBI:50502
EC 2.5.1.15 (dihydropteroate synthase) inhibitor
potassium channel modulator
Drug used to cause constriction of the blood vessels.
vasoconstrictor agent
An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-amylase (EC 3.2.1.1).
1,4-alpha-D-glucan glucanohydrolase inhibitor
1,4-alpha-D-glucan glucanohydrolase inhibitors
4-alpha-D-glucan glucanohydrolase inhibitor
4-alpha-D-glucan glucanohydrolase inhibitors
EC 3.2.1.1 (alpha-amylase) inhibitors
EC 3.2.1.1 inhibitor
EC 3.2.1.1 inhibitors
Taka-amylase A inhibitor
Taka-amylase A inhibitors
alpha-amylase (EC 3.2.1.1) inhibitor
alpha-amylase (EC 3.2.1.1) inhibitors
alpha-amylase inhibitor
alpha-amylase inhibitors
endoamylase inhibitor
endoamylase inhibitors
glycogenase inhibitor
glycogenase inhibitors
CHEBI:50627
EC 3.2.1.1 (alpha-amylase) inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
COX-2 inhibitor
COX-2 inhibitors
PGHS-2 inhibitor
PGHS-2 inhibitors
cyclo-oxygenase 2 inhibitor
cyclo-oxygenase 2 inhibitors
cyclo-oxygenase-2 inhibitor
cyclo-oxygenase-2 inhibitors
cyclooxygenase 2 inhibitors
cyclooxygenase-2 inhibitor
cyclooxygenase-2 inhibitors
prostaglandin H synthase-2 inhibitor
prostaglandin H synthase-2 inhibitors
prostaglandin-endoperoxide synthase 2 inhibitor
prostaglandin-endoperoxide synthase 2 inhibitors
CHEBI:50629
cyclooxygenase 2 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
COX-1 inhibitor
COX-1 inhibitors
PTGS1 inhibitor
PTGS1 inhibitors
cyclo-oxygenase 1 inhibitor
cyclo-oxygenase 1 inhibitors
cyclooxygenase 1 inhibitors
cyclooxygenase-1 inhibitor
cyclooxygenase-1 inhibitors
prostaglandin G/H synthase 1 inhibitor
prostaglandin G/H synthase 1 inhibitors
prostaglandin H2 synthase 1 inhibitor
prostaglandin H2 synthase 1 inhibitors
prostaglandin-endoperoxide synthase 1 inhibitor
prostaglandin-endoperoxide synthase 1 inhibitors
CHEBI:50630
cyclooxygenase 1 inhibitor
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
anti-osteopenia agent
anti-osteopenia agents
anti-osteopenia drug
anti-osteopenia drugs
anti-osteoporosis agent
anti-osteoporosis agents
anti-osteoporosis drug
anti-osteoporosis drugs
anti-osteoporotic
anti-osteoporotic agent
anti-osteoporotic agents
anti-osteoporotic drug
anti-osteoporotic drugs
anti-osteoporotics
antiosteoporotic
antiosteoporotics
bone density conservation agents
bone density conservation drug
bone density conservation drugs
CHEBI:50646
bone density conservation agent
A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
antithyroid agent
antithyroid agents
antithyroid drugs
CHEBI:50671
antithyroid drug
A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.
Beilstein:108646
CAS:60-56-0
DrugBank:DB00763
Drug_Central:1745
LINCS:LSM-5646
PMID:17438883
PMID:24443787
PMID:7454742
PMID:9172960
Reaxys:108646
1-methyl-1,3-dihydro-2H-imidazole-2-thione
Methimazole
1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE
1-Methylimidazole-2(3H)-thione
Danantizol
Favistan
Strumazol
Tapazole
Thacapzol
USAF el-30
thiamazol
thiamazole
thiamazolum
tiamazol
CHEBI:50673
methimazole
Beilstein:108646
Beilstein
CAS:60-56-0
ChemIDplus
CAS:60-56-0
NIST Chemistry WebBook
Drug_Central:1745
DrugCentral
PMID:17438883
Europe PMC
PMID:24443787
Europe PMC
PMID:7454742
Europe PMC
PMID:9172960
Europe PMC
Reaxys:108646
Reaxys
An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
7,8-dihydrofolate reductase inhibitor
7,8-dihydrofolate reductase inhibitors
DHFR inhibitor
DHFR inhibitors
EC 1.5.1.3 (dihydrofolate reductase) inhibitors
EC 1.5.1.3 inhibitor
EC 1.5.1.3 inhibitors
NADPH-dihydrofolate reductase inhibitor
NADPH-dihydrofolate reductase inhibitors
dihydrofolate reductase (EC 1.5.1.3) inhibitor
dihydrofolate reductase (EC 1.5.1.3) inhibitors
dihydrofolate reductase inhibitor
dihydrofolate reductase inhibitors
dihydrofolic acid reductase inhibitor
dihydrofolic acid reductase inhibitors
dihydrofolic reductase inhibitor
dihydrofolic reductase inhibitors
folic acid reductase inhibitor
folic acid reductase inhibitors
folic reductase inhibitor
folic reductase inhibitors
tetrahydrofolate dehydrogenase inhibitor
tetrahydrofolate dehydrogenase inhibitors
CHEBI:50683
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
A substance used either in the prevention or facilitation of pregnancy.
reproductive control agent
reproductive control drugs
CHEBI:50689
reproductive control drug
A chemical substance that interrupts pregnancy after implantation.
abortifacient agent
abortifacient agents
abortifacient drug
abortifacient drugs
abortifacients
CHEBI:50691
abortifacient
A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Beilstein:3077644
CAS:10118-90-8
DrugBank:DB01017
Drug_Central:1813
LIPID_MAPS_instance:LMPK07000002
PMID:28709717
PMID:31630007
PMID:31719236
PMID:31733348
Reaxys:3077644
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Minocycline
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
7-Dimethylamino-6-demethyl-6-deoxytetracycline
minociclina
minociclinum
minocycline
minomycin
CHEBI:50694
minocycline
Beilstein:3077644
Beilstein
CAS:10118-90-8
ChemIDplus
Drug_Central:1813
DrugCentral
LIPID_MAPS_instance:LMPK07000002
LIPID MAPS
PMID:28709717
Europe PMC
PMID:31630007
Europe PMC
PMID:31719236
Europe PMC
PMID:31733348
Europe PMC
Reaxys:3077644
Reaxys
A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.
CHEBI:50739
estrogen receptor modulator
C24H29ClO4
[H][C@@]12C[C@]1([H])[C@@]1(C)C(=CC2=O)C(Cl)=C[C@@]2([H])[C@]3([H])CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@]12[H]
CAS:427-51-0
Wikipedia:Cyproterone_Acetate
6-chloro-3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-dien-17-yl acetate
CPA
cyproterone acetate
A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.
gestagen
gestagens
progestagen
progestagens
progestogens
CHEBI:50745
progestogen
A drug used to treat psoriasis.
antipsoriatic agent
antipsoriatic drug
CHEBI:50748
antipsoriatic
A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
DNA gyrase inhibitor
DNA gyrase inhibitors
DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor
DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors
DNA topoisomerase (ATP-hydrolysing) inhibitor
DNA topoisomerase (ATP-hydrolysing) inhibitors
DNA topoisomerase II inhibitor
DNA topoisomerase II inhibitors
EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor
EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors
EC 5.99.1.3 inhibitor
EC 5.99.1.3 inhibitors
inhibitor of type II topoisomerase
inhibitors of type II topoisomerase
topoisomerase II inhibitor
topoisomerase II inhibitors
topoisomerase-II inhibitor
topoisomerase-II inhibitors
type II DNA topoisomerase inhibitor
type II DNA topoisomerase inhibitors
CHEBI:50750
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
anti-estrogenic agent
anti-estrogenic drug
anti-oestrogen
anti-oestrogenic agent
anti-oestrogenic drug
antiestrogen
antiestrogenic agent
antiestrogenic drug
antioestrogen
antioestrogenic agent
antioestrogenic drug
CHEBI:50751
anti-estrogen
Beilstein:4237530
CAS:54048-10-1
DrugBank:DB00294
Drug_Central:1110
17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
3-Ketodesogestrel
3-Oxodesogestrel
Implanon
etonogestrel
etonogestrelum
CHEBI:50777
etonogestrel
Beilstein:4237530
Beilstein
CAS:54048-10-1
ChemIDplus
Drug_Central:1110
DrugCentral
An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC 1.14.14.14) and so reduces production of estrogenic steroid hormones.
EC 1.14.14.14 (aromatase) inhibitors
EC 1.14.14.14 inhibitor
EC 1.14.14.14 inhibitors
aromatase (EC 1.14.14.14) inhibitor
aromatase (EC 1.14.14.14) inhibitors
aromatase inhibitor
aromatase inhibitors
estrogen synthase inhibitor
estrogen synthase inhibitors
estrogen synthetase inhibitor
estrogen synthetase inhibitors
oestrogen synthase inhibitor
oestrogen synthase inhibitors
oestrogen synthetase inhibitor
oestrogen synthetase inhibitors
CHEBI:50790
EC 1.14.14.14 (aromatase) inhibitor
An antagonist at the estrogen receptor.
estrogen receptor antagonists
CHEBI:50792
estrogen receptor antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
oestrogen antagonist
CHEBI:50837
estrogen antagonist
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Biomodulator
Immune factor
Immunologic factor
Immunological factor
immunomodulators
CHEBI:50846
immunomodulator
A drug used to treat allergic reactions.
anti-allergic drug
anti-allergic agent
CAS:153559-49-0
DrugBank:DB00307
Drug_Central:361
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
bexarotene
bexaroteno
bexarotenum
p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
CHEBI:50859
bexarotene
CAS:153559-49-0
ChemIDplus
Drug_Central:361
DrugCentral
Any molecular entity that contains carbon.
organic compounds
organic entity
organic molecular entity
An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
insulin-sensitizing drug
A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
Wikipedia:Genotoxicity
genotoxic agent
genotoxic agents
genotoxins
CHEBI:50902
genotoxin
A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
agente carcinogeno
cancerigene
cancerogene
carcinogen
carcinogene
carcinogenic agents
carcinogeno
carcinogens
CHEBI:50903
carcinogenic agent
A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
Wikipedia:Allergen
alergeno
allergene
allergenic agent
CHEBI:50904
allergen
A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
agent teratogene
teratogen
teratogeno
CHEBI:50905
teratogenic agent
A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
A role played by an entity exihibiting itself through the ability to induce damage to the liver in animals.
agente hepatotoxico
hepatotoxic agents
hepatotoxicant
hepatotoxicants
hepatotoxin
hepatotoxins
hepatoxic agent
hepatoxicant
CHEBI:50908
hepatotoxic agent
A role played by aan entity exihibiting itself through the ability to induce damage to the heart and cardiomyocytes.
cardiotoxic agent
A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
CAS:284461-73-0
DrugBank:DB00398
Drug_Central:2459
LINCS:LSM-1008
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
sorafenib
sorafenibum
CHEBI:50924
sorafenib
CAS:284461-73-0
ChemIDplus
Drug_Central:2459
DrugCentral
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
A-kinase inhibitor
A-kinase inhibitors
AP50 kinase inhibitor
AP50 kinase inhibitors
ATP-protein transphosphorylase inhibitor
ATP-protein transphosphorylase inhibitors
ATP:protein phosphotransferase (non-specific) inhibitor
ATP:protein phosphotransferase (non-specific) inhibitors
BR serine/threonine-protein kinase 2 inhibitor
BR serine/threonine-protein kinase 2 inhibitors
CK-2 inhibitor
CK-2 inhibitors
CKI inhibitor
CKI inhibitors
CKII inhibitor
CKII inhibitors
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors
EC 2.7.11.1 inhibitor
EC 2.7.11.1 inhibitors
HIPK2 inhibitor
HIPK2 inhibitors
Hpr kinase inhibitor
Hpr kinase inhibitors
M phase-specific cdc2 kinase inhibitor
M phase-specific cdc2 kinase inhibitors
MKNK2 inhibitor
MKNK2 inhibitors
PAK-1 inhibitor
PAK-1 inhibitors
PAK1 inhibitor
PAK1 inhibitors
PKA inhibitor
PKA inhibitors
Prp4 protein kinase inhibitor
Prp4 protein kinase inhibitors
Raf kinase inhibitor
Raf kinase inhibitors
Raf-1 inhibitor
Raf-1 inhibitors
STK32 inhibitor
STK32 inhibitors
T-antigen kinase inhibitor
T-antigen kinase inhibitors
WEE1Hu inhibitor
WEE1Hu inhibitors
Wee 1-like kinase inhibitor
Wee 1-like kinase inhibitors
Wee-kinase inhibitor
Wee-kinase inhibitors
betaIIPKC inhibitor
betaIIPKC inhibitors
cAMP-dependent protein kinase A inhibitor
cAMP-dependent protein kinase A inhibitors
cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitors
cGMP-dependent protein kinase inhibitor
cGMP-dependent protein kinase inhibitors
calcium-dependent protein kinase C inhibitor
calcium-dependent protein kinase C inhibitors
calcium/phospholipid-dependent protein kinase inhibitor
calcium/phospholipid-dependent protein kinase inhibitors
casein kinase (phosphorylating) inhibitor
casein kinase (phosphorylating) inhibitors
casein kinase 2 inhibitor
casein kinase 2 inhibitors
casein kinase I inhibitor
casein kinase I inhibitors
casein kinase II inhibitor
casein kinase II inhibitors
casein kinase inhibitor
casein kinase inhibitors
cyclic AMP-dependent protein kinase A inhibitor
cyclic AMP-dependent protein kinase A inhibitors
cyclic AMP-dependent protein kinase inhibitor
cyclic AMP-dependent protein kinase inhibitors
cyclic monophosphate-dependent protein kinase inhibitor
cyclic monophosphate-dependent protein kinase inhibitors
cyclic nucleotide-dependent protein kinase inhibitor
cyclic nucleotide-dependent protein kinase inhibitors
cyclin-dependent kinase inhibitor
cyclin-dependent kinase inhibitors
dsk1 inhibitor
dsk1 inhibitors
epsilon PKC inhibitor
epsilon PKC inhibitors
glycogen synthase a kinase inhibitor
glycogen synthase a kinase inhibitors
glycogen synthase kinase inhibitor
glycogen synthase kinase inhibitors
hydroxyalkyl-protein kinase inhibitor
hydroxyalkyl-protein kinase inhibitors
mitogen-activated S6 kinase inhibitor
mitogen-activated S6 kinase inhibitors
non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor
non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors
non-specific serine/threonine protein kinase inhibitor
non-specific serine/threonine protein kinase inhibitors
p21 activated kinase-1 inhibitor
p21 activated kinase-1 inhibitors
p82 kinase inhibitor
p82 kinase inhibitors
phosphorylase b kinase kinase inhibitor
phosphorylase b kinase kinase inhibitors
protein glutamyl kinase inhibitor
protein glutamyl kinase inhibitors
protein kinase (phosphorylating) inhibitor
protein kinase (phosphorylating) inhibitors
protein kinase A inhibitor
protein kinase A inhibitors
protein kinase CK2 inhibitor
protein kinase CK2 inhibitors
protein kinase p58 inhibitor
protein kinase p58 inhibitors
protein phosphokinase inhibitor
protein phosphokinase inhibitors
protein serine kinase inhibitor
protein serine kinase inhibitors
protein serine-threonine kinase inhibitor
protein serine-threonine kinase inhibitors
protein-aspartyl kinase inhibitor
protein-aspartyl kinase inhibitors
protein-cysteine kinase inhibitor
protein-cysteine kinase inhibitors
protein-serine kinase inhibitor
protein-serine kinase inhibitors
protein-serine/threonine kinase inhibitors
ribosomal S6 protein kinase inhibitor
ribosomal S6 protein kinase inhibitors
ribosomal protein S6 kinase II inhibitor
ribosomal protein S6 kinase II inhibitors
serine kinase inhibitor
serine kinase inhibitors
serine protein kinase inhibitor
serine protein kinase inhibitors
serine(threonine) protein kinase inhibitor
serine(threonine) protein kinase inhibitors
serine-specific protein kinase inhibitor
serine-specific protein kinase inhibitors
serine/threonine protein kinase inhibitor
serine/threonine protein kinase inhibitors
threonine-specific protein kinase inhibitor
threonine-specific protein kinase inhibitors
twitchin kinase inhibitor
twitchin kinase inhibitors
type-2 casein kinase inhibitor
type-2 casein kinase inhibitors
CHEBI:50925
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
CHEBI:50926
angiogenesis modulating agent
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
SSRI
serotonin reuptake inhibitor
CHEBI:50949
serotonin uptake inhibitor
A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any unsaturated fatty acid.
PMID:13152086
unsaturated fatty acyl-CoA
A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
DARI
DRI
dopamine reuptake inhibitor
dopamine reuptake inhibitors
dopamine uptake inhibitors
CHEBI:51039
dopamine uptake inhibitor
A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
hormone receptor modulators
CHEBI:51061
hormone receptor modulator
A role played by the molecular entity or part thereof within a chemical context.
CHEBI:51086
chemical role
Beilstein:2008796
CAS:76-43-7
DrugBank:DB01185
Drug_Central:1210
LIPID_MAPS_instance:LMST02020025
9-fluoro-11beta,17beta-dihydroxy-17alpha-methylandrost-4-en-3-one
11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one
17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone
9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one
9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone
Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-
fluoximesterona
fluoxymesterone
fluoxymesteronum
CHEBI:5120
fluoxymesterone
Beilstein:2008796
Beilstein
CAS:76-43-7
ChemIDplus
Drug_Central:1210
DrugCentral
LIPID_MAPS_instance:LMST02020025
LIPID MAPS
Beilstein:2157663
CAS:13311-84-7
DrugBank:DB00499
Drug_Central:1223
LINCS:LSM-2621
2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Flutamide
4'-nitro-3'-trifluoromethylisobutyranilide
Eulexin
Niftolide
alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-propionotoluidide
flutamida
flutamide
flutamidum
niftolid
CHEBI:5132
flutamide
Beilstein:2157663
ChemIDplus
CAS:13311-84-7
ChemIDplus
Drug_Central:1223
DrugCentral
A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
muscle relaxants
CHEBI:51371
muscle relaxant
A drug used for its actions on skeletal muscle.
CHEBI:51372
neuromuscular agent
A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems.
CHEBI:51374
GABA agent
COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
ATC:C02KX01
CAS:147536-97-8
DrugBank:DB00559
Drug_Central:392
LINCS:LSM-5825
Wikipedia:Bosentan
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
bosentan
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
CHEBI:51450
bosentan
CAS:147536-97-8
ChemIDplus
Drug_Central:392
DrugCentral
A hormone antagonist that blocks endothelin receptors.
ERA
CHEBI:51451
endothelin receptor antagonist
CAS:93390-81-9
Drug_Central:1247
Fosphenytoin
cerebyx
fosphenytoin sodium
fosphenytoin sodium hydrate
CHEBI:5165
Fosphenytoin
Drug_Central:1247
DrugCentral
A biological role played by the molecular entity or part thereof within a biochemical context.
CHEBI:52206
biochemical role
CHEBI:52208
biophysical role
A role played by the molecular entity or part thereof which causes the development of a pathological process.
etiopathogenetic agent
etiopathogenetic role
CHEBI:52209
aetiopathogenetic role
A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
CHEBI:52210
pharmacological role
Any molecule or ion capable of binding to a central metal atom to form coordination complexes.
ligands
CHEBI:52214
ligand
Any substance introduced into a living organism with therapeutic or diagnostic purpose.
farmaco
medicament
pharmaceuticals
CHEBI:52217
pharmaceutical
A chemical substance that encourages a cell to commence cell division, triggering mitosis.
mitogens
CHEBI:52290
mitogen
An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*).
EC 3.2.1.* (glycosidase) inhibitors
EC 3.2.1.* inhibitor
EC 3.2.1.* inhibitors
glycosidase (EC 3.2.1.*) inhibitor
glycosidase (EC 3.2.1.*) inhibitors
glycosidase inhibitor
glycosidase inhibitors
glycoside hydrolase inhibitors
CHEBI:52424
EC 3.2.1.* (glycosidase) inhibitor
An inhibitor of ribonuclease H (EC 3.1.26.13), an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid.
EC 3.1.26.13 (retroviral ribonuclease H) inhibitors
EC 3.1.26.13 inhibitor
EC 3.1.26.13 inhibitors
HIV RNase H inhibitor
HIV RNase H inhibitors
HIV-1 RNase H inhibitor
HIV-1 RNase H inhibitors
HIV-1 ribonuclease H inhibitor
HIV-1 ribonuclease H inhibitors
RT/RNase H inhibitor
RT/RNase H inhibitors
retroviral reverse transcriptase RNaseH inhibitor
retroviral reverse transcriptase RNaseH inhibitors
retroviral ribonuclease H (EC 3.1.26.13) inhibitor
retroviral ribonuclease H (EC 3.1.26.13) inhibitors
retroviral ribonuclease H inhibitor
CHEBI:52629
EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
C19H25BN4O4
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
CAS:179324-69-7
DrugBank:DB00188
Drug_Central:391
LINCS:LSM-6281
PMID:18484921
PMID:18980173
PMID:21504411
PMID:21865767
Reaxys:8723817
Wikipedia:Bortezomib
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
PS 341
PS-341
Velcade
bortezomib
CHEBI:52717
bortezomib
CAS:179324-69-7
ChemIDplus
Drug_Central:391
DrugCentral
PMID:18484921
Europe PMC
PMID:18980173
Europe PMC
PMID:21504411
Europe PMC
PMID:21865767
Europe PMC
Reaxys:8723817
Reaxys
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
proteasome inhibitors
CHEBI:52726
proteasome inhibitor
C15H22O3
Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
Beilstein:1881200
CAS:25812-30-0
DrugBank:DB01241
Drug_Central:1285
LINCS:LSM-2227
Wikipedia:Gemfibrozil
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Gemfibrozil
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
Gemfibrozilo
Lopid
gemfibrozil
gemfibrozilum
CHEBI:5296
gemfibrozil
Beilstein:1881200
Beilstein
CAS:25812-30-0
ChemIDplus
Drug_Central:1285
DrugCentral
A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
topoisomerase IV inhibitors
CHEBI:53559
topoisomerase IV inhibitor
An entity which inhibits the activity of HIV-1 reverse transcriptase.
HIV-1 reverse transcriptase inhibitors
reverse transcriptase inhibitor
reverse transcriptase inhibitors
CHEBI:53756
HIV-1 reverse transcriptase inhibitor
A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
antispasmodics
CHEBI:53784
antispasmodic drug
An urea that has formula C23H28ClN3O5S.
CASRN:10238-21-8
DrugBank:DB01016
InChIKeyZ:NNLBTZKUZBEKO-UHFFFAOYSA-N
Wikipedia:Glyburide
glibenclamide
glyburide
A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.
gastrointestinal agent
gastrointestinal agents
gastrointestinal drugs
CHEBI:55324
gastrointestinal drug
A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.
Beilstein:7408417
CAS:166663-25-8
DrugBank:DB00362
PMID:15482216
PMID:16770294
PMID:17316149
PMID:19072176
PMID:19113794
PMID:19877739
PMID:19877740
PMID:19877741
PMID:19877742
PMID:24165173
PMID:24955796
PMID:25473029
Reaxys:7408417
N-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxamide
Eraxis
anidulafungin
anidulafungina
anidulafungine
anidulafunginum
CHEBI:55346
anidulafungin
Beilstein:7408417
Beilstein
CAS:166663-25-8
ChemIDplus
CAS:166663-25-8
DrugBank
PMID:15482216
Europe PMC
PMID:16770294
Europe PMC
PMID:17316149
Europe PMC
PMID:19072176
Europe PMC
PMID:19113794
Europe PMC
PMID:19877739
Europe PMC
PMID:19877740
Europe PMC
PMID:19877741
Europe PMC
PMID:19877742
Europe PMC
PMID:24165173
Europe PMC
PMID:24955796
Europe PMC
PMID:25473029
Europe PMC
Reaxys:7408417
Reaxys
A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.
malondialdehyde
A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.
Beilstein:8076827
CAS:95233-18-4
DrugBank:DB01117
Drug_Central:258
PMID:10658902
PMID:11956677
PMID:12791689
PMID:14727190
PMID:15044733
PMID:15718226
PMID:21735454
PMID:23292347
2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone
2-(trans-4-(p-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone
Acuvel
Mepron
Wellvone
atovaquone
CHEBI:575568
atovaquone
Beilstein:8076827
Beilstein
CAS:95233-18-4
ChemIDplus
CAS:95233-18-4
DrugBank
Drug_Central:258
DrugCentral
PMID:10658902
Europe PMC
PMID:11956677
Europe PMC
PMID:12791689
Europe PMC
PMID:14727190
Europe PMC
PMID:15044733
Europe PMC
PMID:15718226
Europe PMC
PMID:21735454
Europe PMC
PMID:23292347
Europe PMC
A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
C13H18O2
CC(C)Cc1ccc(cc1)C(C)C(O)=O
CAS:15687-27-1
DrugBank:DB01050
2-[4-(2-methylpropyl)phenyl]propanoic acid
ibuprofen
Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
antigen
Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the activity of a serine endopeptidase (EC 3.4.21.*).
EC 3.4.21.* (serine endopeptidase) inhibitors
EC 3.4.21.* inhibitor
EC 3.4.21.* inhibitors
inhibitor of serine endopeptidase (EC 3.4.21.*)
inhibitor of serine endopeptidase (EC 3.4.21.*)s
serine endopeptidase inhibitor
serine endopeptidase inhibitors
CHEBI:5924
EC 3.4.21.* (serine endopeptidase) inhibitor
An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132).
EC 1.14.13.132 (squalene monooxygenase) inhibitors
squalene 2,3-oxidocyclase inhibitor
squalene 2,3-oxidocyclase inhibitors
squalene epoxidase inhibitor
squalene epoxidase inhibitors
squalene hydroxylase inhibitor
squalene hydroxylase inhibitors
squalene monooxygenase (EC 1.14.13.132) inhibitor
squalene monooxygenase (EC 1.14.13.132) inhibitors
squalene monooxygenase inhibitor
squalene monooxygenase inhibitors
squalene oxydocyclase inhibitor
squalene oxydocyclase inhibitors
squalene-2,3-epoxidase inhibitor
squalene-2,3-epoxidase inhibitors
squalene-2,3-epoxide cyclase inhibitor
squalene-2,3-epoxide cyclase inhibitors
CHEBI:59285
EC 1.14.13.132 (squalene monooxygenase) inhibitor
CAS:76543-88-9
Interferon alfa-2a
Interferon alpha-2A
CHEBI:5937
Interferon alfa-2a
CAS:145155-23-3
Interferon beta-1b
CHEBI:5938
Interferon beta-1b
Any substance that inhibits the synthesis of DNA.
DNA synthesis inhibitors
CHEBI:59517
DNA synthesis inhibitor
CAS:54-92-2
Drug_Central:1480
LINCS:LSM-5940
Iproniazid
euphozid
iprazid
iprazide
iproniazid phosphate
iproniazide
iproniazide phosphate
marsilid
CHEBI:5958
Iproniazid
Drug_Central:1480
DrugCentral
A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner.
electrophile
electrophiles
electrophilic reagents
electrophilic reagent
A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
nucleophile
nucleophilic reagent
A synthetic progestogen.
progestins
CHEBI:59826
progestin
A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
PMID:22470838
HIV entry inhibitor
HIV entry inhibitors
HIV fusion inhibitors
CHEBI:59886
HIV fusion inhibitor
PMID:22470838
Europe PMC
A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.
DNA nucleotidyltransferase (RNA-directed) inhibitor
DNA nucleotidyltransferase (RNA-directed) inhibitors
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors
EC 2.7.7.49 inhibitor
EC 2.7.7.49 inhibitors
RNA revertase inhibitor
RNA revertase inhibitors
RNA-dependent DNA polymerase inhibitor
RNA-dependent DNA polymerase inhibitors
RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor
RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors
RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor
RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors
RNA-directed DNA polymerase inhibitor
RNA-directed DNA polymerase inhibitors
RNA-instructed DNA polymerase inhibitor
RNA-instructed DNA polymerase inhibitors
RT inhibitor
RT inhibitors
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors
reverse transcriptase inhibitor
reverse transcriptase inhibitors
revertase inhibitor
revertase inhibitors
telomerase inhibitor
telomerase inhibitors
CHEBI:59897
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy.
Beilstein:9610508
CAS:235114-32-6
DrugBank:DB01141
PMID:17194830
PMID:17307974
PMID:17325217
PMID:17325225
PMID:17420211
PMID:17785512
5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate
5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-(3R)-3-hydroxy-L-glutaminyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}
Mycamine
micafungin
CHEBI:600520
micafungin
Beilstein:9610508
Beilstein
CAS:235114-32-6
ChemIDplus
PMID:17194830
ChEMBL
PMID:17307974
ChEMBL
PMID:17325217
ChEMBL
PMID:17325225
ChEMBL
PMID:17420211
ChEMBL
PMID:17785512
ChEMBL
A derivative of phosphatidylinositol in which the inositol ring is phosphorylated at three unspecified positions.
phosphatidylinositol trisphosphate
A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*).
EC 3.4.* (hydrolase acting on peptide bond) inhibitor
EC 3.4.* (hydrolase acting on peptide bonds) inhibitors
EC 3.4.* (hydrolases acting on peptide bond) inhibitors
EC 3.4.* (peptidase) inhibitor
EC 3.4.* (peptidase) inhibitors
EC 3.4.* inhibitor
EC 3.4.* inhibitors
inhibitor of hydrolases acting on peptide bond (EC 3.4.*)
inhibitors of hydrolases acting on peptide bond (EC 3.4.*)
peptidase inhibitors
protease inhibitor
protease inhibitors
CHEBI:60258
EC 3.4.* (hydrolases acting on peptide bond) inhibitor
A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
C6H7N3O
NNC(=O)c1ccncc1
CAS:54-85-3
DrugBank:DB00951
LINCS:LSM-6682
pyridine-4-carbohydrazide
isoniazide
A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
Beilstein:1885770
CAS:4759-48-2
DrugBank:DB00982
Drug_Central:1508
LIPID_MAPS_instance:LMPR01090021
PMID:11606947
PMID:11866680
PMID:15304471
PMID:18077132
PMID:18788179
PMID:19568610
PMID:20482692
PMID:23676507
PMID:9807973
Reaxys:1885770
(2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
(7E,9E,11E,13Z)-retinoic acid
13-RA
13-cis-Vitamin A acid
13-cis-retinoic acid
Accutane
Amnesteem
Claravis
Neovitamin A acid
cis-RA
isotretinoin
isotretinoina
isotretinoine
isotretinoino
isotretinoinum
CHEBI:6067
isotretinoin
Beilstein:1885770
Beilstein
CAS:4759-48-2
ChemIDplus
Drug_Central:1508
DrugCentral
LIPID_MAPS_instance:LMPR01090021
LIPID MAPS
PMID:11606947
Europe PMC
PMID:11866680
Europe PMC
PMID:15304471
Europe PMC
PMID:18077132
Europe PMC
PMID:18788179
Europe PMC
PMID:19568610
Europe PMC
PMID:20482692
Europe PMC
PMID:23676507
Europe PMC
PMID:9807973
Europe PMC
Reaxys:1885770
Reaxys
An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
CAS:84625-61-6
DrugBank:DB01167
PMID:11219548
PMID:11403818
PMID:11422002
PMID:15521894
PMID:19025521
PMID:20400651
PMID:25326091
2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Itraconazole
itraconazole
Itrizole (TN)
Oriconazole
Sporanox (TN)
CHEBI:6076
itraconazole
CAS:84625-61-6
ChemIDplus
PMID:11219548
Europe PMC
PMID:11403818
Europe PMC
PMID:11422002
Europe PMC
PMID:15521894
Europe PMC
PMID:19025521
Europe PMC
PMID:20400651
Europe PMC
PMID:25326091
Europe PMC
Any substance which inhibits the action of receptors for excitatory amino acids.
EAA receptor antagonist
EAA receptor antagonists
excitatory amino acid antagonists
excitatory amino acid receptor antagonist
excitatory amino acid receptor antagonists
CHEBI:60798
excitatory amino acid antagonist
A lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.
BMP is a negatively charged phospholipid found almost exclusively in late endosomes/lysosomes.
BMP content is higher in alveolar macrophages (18% of total phospholipids) than in other cell types.
BMP is a structural isomer of phosphatidylglycerol (PG) and is synthesized through a series of acylation and deacylation steps involving a transacylase.
BMP its unusual sn-1;sn-1′ structural configuration (based on the phosphate-linked glycerol carbon), which is not observed in other phospholipids.
This unusual configuration is thought to play a role in the resistance of BMP to many phospholipases, and its stability in late endosomes/lysosomes. BMP stimulates the degradation of glycosphingolipids in coordination with lipid binding proteins (saposins) in lysosomes.
PMID:25795792
BMP
LBPA
bis(monoacylglycerol) hydrogen phosphate
lysobisphosphatidic acid
PMID:22960355
Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
tubulin modulators
CHEBI:60832
tubulin modulator
A poison that interferes with the function of the kidneys.
nephrotoxins
CHEBI:61015
nephrotoxin
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
EC 3.5.1.98 (histone deacetylase) inhibitors
EC 3.5.1.98 inhibitor
EC 3.5.1.98 inhibitors
HDAC inhibitor
HDAC inhibitors
HDACi
HDACis
HDI
HDIs
histone amidohydrolase inhibitor
histone amidohydrolase inhibitors
histone deacetylase (EC 3.5.1.98) inhibitor
histone deacetylase (EC 3.5.1.98) inhibitors
histone deacetylase inhibitor
histone deacetylase inhibitors
CHEBI:61115
EC 3.5.1.98 (histone deacetylase) inhibitor
Any organic molecular entity derived from a fatty acid.
FA derivative
fatty acid derivative
A fatty acyl-CoA in which the fatty acyl group has a chain length greater than C22.
VLCFA-CoA
very long-chain fatty acyl-CoA
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
PMID:17099073
microtubule destabilising agent
microtubule destabilising agents
microtubule destabilising role
microtubule destabilizing role
microtubule-destabilising agents
microtubule-destabilizing agent
microtubule-destabilizing agents
CHEBI:61951
microtubule-destabilising agent
PMID:17099073
Europe PMC
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
AATK inhibitor
AATYK inhibitor
AATYK2 inhibitor
AATYK3 inhibitor
ACH inhibitor
ALK inhibitor
ALK inhibitors
ARK inhibitor
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors
AXL inhibitor
BRT inhibitor
Bek inhibitor
Bfgfr inhibitor
Bsk inhibitor
C-FMS inhibitor
CAK inhibitor
CCK4 inhibitor
CD115 inhibitor
CD135 inhibitor
CDw135 inhibitor
CFD1 inhibitor
CKIT inhibitor
CSF1R inhibitor
Cek1 inhibitor
Cek10 inhibitor
Cek11 inhibitor
Cek2 inhibitor
Cek3 inhibitor
Cek5 inhibitor
Cek6 inhibitor
Cek7 inhibitor
DAlk inhibitor
DDR1 inhibitor
DDR2 inhibitor
DKFZp434C1418 inhibitor
DRT inhibitor
DTK inhibitor
Dek inhibitor
Drosophila Eph kinase inhibitor
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors
EC 2.7.10.1 inhibitor
EC 2.7.10.1 inhibitors
ECK inhibitor
EDDR1 inhibitor
EGFR inhibitor
EPH inhibitor
EPHA1 inhibitor
EPHA2 inhibitor
EPHA6 inhibitor
EPHA7 inhibitor
EPHA8 inhibitor
EPHB1 inhibitor
EPHB2 inhibitor
EPHB3 inhibitor
EPHB4 inhibitor
EPHT inhibitor
EPHT2 inhibitor
EPHT3 inhibitor
EPHX inhibitor
ERBB inhibitor
ERBB1 inhibitor
ERBB2 inhibitor
ERBB3 inhibitor
ERBB4 inhibitor
ERK inhibitor
Ebk inhibitor
Eek inhibitor
Ehk2 inhibitor
Ehk3 inhibitor
Elk inhibitor
EphB5 inhibitor
Eyk inhibitor
FGFR1 inhibitor
FGFR2 inhibitor
FGFR3 inhibitor
FGFR4 inhibitor
FLG inhibitor
FLK1 inhibitor
FLK2 inhibitor
FLT1 inhibitor
FLT2 inhibitor
FLT3 inhibitor
FLT4 inhibitor
FMS inhibitor
Fv2 inhibitor
HBGFR inhibitor
HEK11 inhibitor
HEK2 inhibitor
HEK3 inhibitor
HEK5 inhibitor
HEK6 inhibitor
HEP inhibitor
HER2 inhibitor
HER3 inhibitor
HER4 inhibitor
HGFR inhibitor
HSCR1 inhibitor
HTK inhibitor
IGF1R inhibitor
INSR inhibitor
INSRR inhibitor
IR inhibitor
IRR inhibitor
JTK12 inhibitor
JTK13 inhibitor
JTK14 inhibitor
JWS inhibitor
K-SAM inhibitor
KDR inhibitor
KGFR inhibitor
KIA0641 inhibitor
KIAA1079 inhibitor
KIAA1459 inhibitor
KIT inhibitor
KLG inhibitor
Kil inhibitor
Kin15 inhibitor
Kin16 inhibitor
LTK inhibitor
MCF3 inhibitor
MEN2A/B inhibitor
MER inhibitor
MERTK inhibitor
MEhk1 inhibitor
MST1R inhibitor
MTC1 inhibitor
MUSK inhibitor
Mdk1 inhibitor
Mdk2 inhibitor
Mdk5 inhibitor
Mep inhibitor
Mlk1 inhibitor
Mlk2 inhibitor
Mrk inhibitor
Myk1 inhibitor
N-SAM inhibitor
NEP inhibitor
NET inhibitor
NGL inhibitor
NOK inhibitor
NTRK1 inhibitor
NTRK2 inhibitor
NTRK3 inhibitor
NTRK4 inhibitor
NTRKR1 inhibitor
NTRKR2 inhibitor
NTRKR3 inhibitor
NYK inhibitor
Neu inhibitor
Nsk2 inhibitor
Nuk inhibitor
PCL inhibitor
PDGFR inhibitor
PDGFRA inhibitor
PDGFRB inhibitor
PHB6 inhibitor
PTK inhibitor
PTK3 inhibitor
PTK7 inhibitor
RET inhibitor
RON inhibitor
ROR1 inhibitor
ROR2 inhibitor
ROS1 inhibitor
RSE inhibitor
RTK inhibitor
RYK inhibitor
SEA inhibitor
SKY inhibitor
STK inhibitor
STK1 inhibitor
Sek2 inhibitor
Sek3 inhibitor
Sek4 inhibitor
Sfr inhibitor
TEK inhibitor
TIE inhibitor
TIE1 inhibitor
TIE2 inhibitor
TIF inhibitor
TKT inhibitor
TRK inhibitor
TRKA inhibitor
TRKB inhibitor
TRKC inhibitor
TRKE inhibitor
TYK1 inhibitor
TYRO10 inhibitor
TYRO3 inhibitor
TYRO7 inhibitor
Tyro11 inhibitor
Tyro5 inhibitor
Tyro6 inhibitor
UFO inhibitor
VEGFR1 inhibitor
VEGFR2 inhibitor
VEGFR3 inhibitor
Vik inhibitor
YK1 inhibitor
Yrk inhibitor
anaplastic lymphoma kinase inhibitor
anaplastic lymphoma kinase inhibitors
ephrin-B3 receptor tyrosine kinase inhibitor
insulin receptor protein-tyrosine kinase inhibitor
neurite outgrowth regulating kinase inhibitor
nork inhibitor
novel oncogene with kinase-domain inhibitor
receptor protein tyrosine kinase inhibitor
receptor protein-tyrosine kinase (EC 2.7.10.1) inhibitor
receptor protein-tyrosine kinase (EC 2.7.10.1) inhibitors
receptor protein-tyrosine kinase inhibitor
receptor protein-tyrosine kinase inhibitors
CHEBI:62434
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
EC 1.2.3.1 (aldehyde oxidase) inhibitors
EC 1.2.3.1 inhibitor
EC 1.2.3.1 inhibitors
aldehyde oxidase (EC 1.2.3.1) inhibitor
aldehyde oxidase (EC 1.2.3.1) inhibitors
aldehyde oxidase inhibitor
aldehyde oxidase inhibitors
aldehyde:oxygen oxidoreductase inhibitor
aldehyde:oxygen oxidoreductase inhibitors
quinoline oxidase inhibitor
quinoline oxidase inhibitors
retinal oxidase inhibitor
retinal oxidase inhibitors
retinoic acid synthase inhibitor
retinoic acid synthase inhibitors
CHEBI:62872
EC 1.2.3.1 (aldehyde oxidase) inhibitor
An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of purine nucleoside phosphorylase (EC 2.4.2.1).
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitors
EC 2.4.2.1 inhibitor
EC 2.4.2.1 inhibitors
PNPase inhibitor
PNPase inhibitors
PUNPI inhibitor
PUNPI inhibitors
PUNPII inhibitor
PUNPII inhibitors
inosine phosphorylase inhibitor
inosine phosphorylase inhibitors
inosine-guanosine phosphorylase inhibitor
inosine-guanosine phosphorylase inhibitors
nucleotide phosphatase inhibitor
nucleotide phosphatase inhibitors
purine deoxynucleoside phosphorylase inhibitor
purine deoxynucleoside phosphorylase inhibitors
purine deoxyribonucleoside phosphorylase inhibitor
purine deoxyribonucleoside phosphorylase inhibitors
purine nucleoside phosphorylase inhibitor
purine nucleoside phosphorylase inhibitors
purine ribonucleoside phosphorylase inhibitor
purine ribonucleoside phosphorylase inhibitors
purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitor
purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitors
purine-nucleoside phosphorylase inhibitor
purine-nucleoside phosphorylase inhibitors
purine-nucleoside:phosphate ribosyltransferase inhibitor
purine-nucleoside:phosphate ribosyltransferase inhibitors
CHEBI:63090
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species.
Wikipedia:Reducing_agent
reducer
reductant
reducing agent
A substance that removes electrons from another reactant in a redox reaction.
oxidant
oxidiser
oxidizer
oxidising agent
A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure.
Beilstein:2948416
CAS:36894-69-6
DrugBank:DB00598
Drug_Central:1531
LINCS:LSM-1282
PMID:21908132
PMID:22300487
PMID:22528277
PMID:23055089
PMID:28166217
Reaxys:2948416
2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
Labetalol
3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
kabetalol
labetalol
labetalolum
CHEBI:6343
labetalol
Beilstein:2948416
Beilstein
CAS:36894-69-6
ChemIDplus
Drug_Central:1531
DrugCentral
PMID:21908132
Europe PMC
PMID:22300487
Europe PMC
PMID:22528277
Europe PMC
PMID:23055089
Europe PMC
PMID:28166217
Europe PMC
Reaxys:2948416
Reaxys
A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase
C10H12N2O4
Cc1cn([C@@H]2O[C@H](CO)C=C2)c(=O)[nH]c1=O
CAS:3056-17-5
DrugBank:DB00649
Drug_Central:2478
LINCS:LSM-5983
Reaxys:618327
Wikipedia:Stavudine
1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Stavudine
d4T
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine
2',3'-Didehydro-3'-deoxythimidine
3'-Deoxy-2'-thymidinene
STV
Sanilvudine
d4T
estavudina
stavudine
stavudinum
CHEBI:63581
stavudine
CAS:3056-17-5
ChemIDplus
Drug_Central:2478
DrugCentral
Reaxys:618327
Reaxys
An aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities
CAS:269055-15-4
DrugBank:DB06414
PMID:21114458
PMID:21142266
PMID:21173188
PMID:21189339
PMID:21383098
PMID:21464253
PMID:21557669
PMID:21600016
PMID:21637112
PMID:21881478
PMID:22011983
PMID:22089378
PMID:22190606
PMID:25017682
Reaxys:8945855
4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile
etravirine
CHEBI:63589
etravirine
CAS:269055-15-4
ChemIDplus
PMID:21114458
Europe PMC
PMID:21142266
Europe PMC
PMID:21173188
Europe PMC
PMID:21189339
Europe PMC
PMID:21383098
Europe PMC
PMID:21464253
Europe PMC
PMID:21557669
Europe PMC
PMID:21600016
Europe PMC
PMID:21637112
Europe PMC
PMID:21881478
Europe PMC
PMID:22011983
Europe PMC
PMID:22089378
Europe PMC
PMID:22190606
Europe PMC
PMID:25017682
Europe PMC
Reaxys:8945855
Reaxys
An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase
CAS:100986-85-4
DrugBank:DB01137
Drug_Central:1569
LINCS:LSM-5270
PMID:21075586
PMID:21965436
PMID:21974858
PMID:22088660
PMID:22221614
Reaxys:5385660
(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
(-)-Ofloxacin
(3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid
(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(S)-Ofloxacin
L-Ofloxacin
Ofloxacin S-(-)-form
levofloxacin
levofloxacine
levofloxacino
levofloxacinum
CHEBI:63598
levofloxacin
CAS:100986-85-4
ChemIDplus
Drug_Central:1569
DrugCentral
PMID:21075586
Europe PMC
PMID:21965436
Europe PMC
PMID:21974858
Europe PMC
PMID:22088660
Europe PMC
PMID:22221614
Europe PMC
Reaxys:5385660
Reaxys
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
CAS:376348-65-1
DrugBank:DB04835
PMID:21134404
PMID:21383098
PMID:21393136
PMID:21505306
PMID:21595497
PMID:21692669
PMID:21987241
PMID:22017448
PMID:22034870
PMID:22064539
PMID:22090117
PMID:22118500
PMID:22174038
PMID:22236118
PMID:22247337
PMID:24419064
PMID:24651825
PMID:24652492
PMID:25017682
Reaxys:10131963
4,4-difluoro-N-{(1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
maraviroc
maravirocum
CHEBI:63608
maraviroc
CAS:376348-65-1
ChemIDplus
PMID:21134404
Europe PMC
PMID:21383098
Europe PMC
PMID:21393136
Europe PMC
PMID:21505306
Europe PMC
PMID:21595497
Europe PMC
PMID:21692669
Europe PMC
PMID:21987241
Europe PMC
PMID:22017448
Europe PMC
PMID:22034870
Europe PMC
PMID:22064539
Europe PMC
PMID:22090117
Europe PMC
PMID:22118500
Europe PMC
PMID:22174038
Europe PMC
PMID:22236118
Europe PMC
PMID:22247337
Europe PMC
PMID:24419064
Europe PMC
PMID:24651825
Europe PMC
PMID:24652492
Europe PMC
PMID:25017682
Europe PMC
Reaxys:10131963
Reaxys
A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
CAS:129618-40-2
DrugBank:DB00238
LINCS:LSM-5336
PMID:1712395
PMID:25017682
PMID:28782122
PMID:28786740
PMID:28819312
PMID:28827836
PMID:28835669
Reaxys:4757598
11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Nevirapine
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
NEV
NVP
Viramune
nevirapine
CHEBI:63613
nevirapine
CAS:129618-40-2
ChemIDplus
PMID:1712395
Europe PMC
PMID:25017682
Europe PMC
PMID:28782122
Europe PMC
PMID:28786740
Europe PMC
PMID:28819312
Europe PMC
PMID:28827836
Europe PMC
PMID:28835669
Europe PMC
Reaxys:4757598
Reaxys
A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.
CAS:174484-41-4
DrugBank:DB00932
PMID:17620375
PMID:20368406
PMID:21041916
PMID:21571982
PMID:21576452
PMID:21825300
PMID:21871444
PMID:22007990
PMID:22096044
PMID:22258921
PMID:25017682
Reaxys:7698323
N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
tipranavir
CHEBI:63628
tipranavir
CAS:174484-41-4
ChemIDplus
PMID:17620375
Europe PMC
PMID:20368406
Europe PMC
PMID:21041916
Europe PMC
PMID:21571982
Europe PMC
PMID:21576452
Europe PMC
PMID:21825300
Europe PMC
PMID:21871444
Europe PMC
PMID:22007990
Europe PMC
PMID:22096044
Europe PMC
PMID:22258921
Europe PMC
PMID:25017682
Europe PMC
Reaxys:7698323
Reaxys
2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Beilstein:618691
CAS:51322-75-9
DrugBank:DB00697
Drug_Central:2683
LINCS:LSM-5242
PMID:21317414
PMID:21733633
PMID:21982341
PMID:22196407
PMID:22223284
Reaxys:618691
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
Tizanidine
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
tizanidina
tizanidine
tizanidinum
CHEBI:63629
tizanidine
Beilstein:618691
ChemIDplus
CAS:51322-75-9
ChemIDplus
Drug_Central:2683
DrugCentral
PMID:21317414
Europe PMC
PMID:21733633
Europe PMC
PMID:21982341
Europe PMC
PMID:22196407
Europe PMC
PMID:22223284
Europe PMC
Reaxys:618691
Reaxys
Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.
DrugBank:DB00323
Drug_Central:2697
LINCS:LSM-5282
PMID:20381177
PMID:20502133
PMID:21521027
PMID:22136163
Reaxys:8151577
(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
3,4-dihydroxy-4'-methyl-5-nitrobenzophenone
3,4-dihydroxy-5-nitro-4'-methylbenzophenone
4'-methyl-3,4-dihydroxy-5-nitrobenzophenone
tolcapone
CHEBI:63630
tolcapone
Drug_Central:2697
DrugCentral
PMID:20381177
Europe PMC
PMID:20502133
Europe PMC
PMID:21521027
Europe PMC
PMID:22136163
Europe PMC
Reaxys:8151577
Reaxys
A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
CAS:84057-84-1
DrugBank:DB00555
Drug_Central:1540
LINCS:LSM-4104
PMID:20825390
PMID:21242744
Reaxys:7589268
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
Lamictal
lamotrigina
lamotrigine
lamotriginum
CHEBI:6367
lamotrigine
CAS:84057-84-1
ChemIDplus
CAS:84057-84-1
NIST Chemistry WebBook
Drug_Central:1540
DrugCentral
PMID:20825390
Europe PMC
PMID:21242744
Europe PMC
Reaxys:7589268
Reaxys
An antogonist that blocks chemokine receptor 5 (CCR5).
CCR-5 antagonist
CCR-5 antagonists
CCR5 antagonist
CCR5 antagonists
chemokine receptor 5 antagonists
CHEBI:63673
chemokine receptor 5 antagonist
Any compound that can be used for the treatment of neurodegenerative disorders.
neuroprotectant
neuroprotectants
neuroprotective agents
CHEBI:63726
neuroprotective agent
C18H23NO6
[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@@](O)(CO)C(=C)C\C(=C\C)C(=O)O3
A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
CAS:23246-96-0
(15Z)-12,18-dihydroxy-13,19-didehydrosenecionan-11,16-dione
riddelliine
An agonist at the estrogen receptor.
estrogen receptor agonist
An agonist that selectively binds to and activates a protein kinase C receptor
protein kinase C agonists
CHEBI:64018
protein kinase C agonist
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Beilstein:4323174
CAS:75706-12-6
DrugBank:DB01097
Drug_Central:1552
LINCS:LSM-3771
PMID:10515382
PMID:10702725
PMID:10890256
PMID:11043056
PMID:11053058
PMID:11067959
PMID:11271257
PMID:11333342
PMID:11340750
PMID:11391470
PMID:11475244
PMID:11522581
PMID:11707749
PMID:11718154
PMID:11876141
PMID:11884931
PMID:11994686
PMID:12017890
PMID:12074690
PMID:12833393
PMID:14622739
PMID:15030575
PMID:15127968
PMID:15127974
PMID:15188371
PMID:15214907
PMID:15385935
PMID:15489872
PMID:15537652
PMID:15652966
PMID:15665760
PMID:15789891
PMID:15899055
PMID:15934905
PMID:16106593
PMID:16142756
PMID:16202258
PMID:16284916
PMID:16638062
PMID:16638420
PMID:16645972
PMID:16688677
PMID:16769661
PMID:16778342
PMID:17366662
PMID:17604599
PMID:17646975
PMID:17854740
PMID:18034546
PMID:18173611
PMID:18413415
PMID:18496682
PMID:18663553
PMID:18688040
PMID:19169882
PMID:19190124
PMID:19344337
PMID:19581389
PMID:19715969
PMID:19751817
PMID:19770782
PMID:7496341
PMID:7676489
PMID:8610393
PMID:9075844
PMID:9123314
PMID:9625011
PMID:9777697
Reaxys:4323174
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Leflunomide
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
Arava
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
leflunomida
leflunomide
leflunomidum
CHEBI:6402
leflunomide
Beilstein:4323174
Beilstein
CAS:75706-12-6
ChemIDplus
Drug_Central:1552
DrugCentral
PMID:10515382
Europe PMC
PMID:10702725
Europe PMC
PMID:10890256
Europe PMC
PMID:11043056
Europe PMC
PMID:11053058
Europe PMC
PMID:11067959
Europe PMC
PMID:11271257
Europe PMC
PMID:11333342
Europe PMC
PMID:11340750
Europe PMC
PMID:11391470
Europe PMC
PMID:11475244
Europe PMC
PMID:11522581
Europe PMC
PMID:11707749
Europe PMC
PMID:11718154
Europe PMC
PMID:11876141
Europe PMC
PMID:11884931
Europe PMC
PMID:11994686
Europe PMC
PMID:12017890
Europe PMC
PMID:12074690
Europe PMC
PMID:12833393
Europe PMC
PMID:14622739
Europe PMC
PMID:15030575
Europe PMC
PMID:15127968
Europe PMC
PMID:15127974
Europe PMC
PMID:15188371
Europe PMC
PMID:15214907
Europe PMC
PMID:15385935
Europe PMC
PMID:15489872
Europe PMC
PMID:15537652
Europe PMC
PMID:15652966
Europe PMC
PMID:15665760
Europe PMC
PMID:15789891
Europe PMC
PMID:15899055
Europe PMC
PMID:15934905
Europe PMC
PMID:16106593
Europe PMC
PMID:16142756
Europe PMC
PMID:16202258
Europe PMC
PMID:16284916
Europe PMC
PMID:16638062
Europe PMC
PMID:16638420
Europe PMC
PMID:16645972
Europe PMC
PMID:16688677
Europe PMC
PMID:16769661
Europe PMC
PMID:16778342
Europe PMC
PMID:17366662
Europe PMC
PMID:17604599
Europe PMC
PMID:17646975
Europe PMC
PMID:17854740
Europe PMC
PMID:18034546
Europe PMC
PMID:18173611
Europe PMC
PMID:18413415
Europe PMC
PMID:18496682
Europe PMC
PMID:18663553
Europe PMC
PMID:18688040
Europe PMC
PMID:19169882
Europe PMC
PMID:19190124
Europe PMC
PMID:19344337
Europe PMC
PMID:19581389
Europe PMC
PMID:19715969
Europe PMC
PMID:19751817
Europe PMC
PMID:19770782
Europe PMC
PMID:7496341
Europe PMC
PMID:7676489
Europe PMC
PMID:8610393
Europe PMC
PMID:9075844
Europe PMC
PMID:9123314
Europe PMC
PMID:9625011
Europe PMC
PMID:9777697
Europe PMC
Reaxys:4323174
Reaxys
An agonist that selectively binds to and activates a protein kinase receptor.
protein kinase agonists
CHEBI:64106
protein kinase agonist
Any chemical substance produced during the conversion of a reactant to a product.
Wikipedia:Reaction_intermediate
reaction intermediate
An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug.
CAS:171228-49-2
DrugBank:DB01263
Drug_Central:3483
PMID:21762211
PMID:21967490
PMID:22058198
PMID:22176629
PMID:22215361
PMID:22215487
PMID:22286158
PMID:22290952
PMID:22303909
PMID:22324990
PMID:22330929
PMID:22380765
PMID:22391464
PMID:22391534
PMID:22427614
Reaxys:8379448
2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-4-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
Noxafil
SCH56592
Sch 56592
Schering 56592
posaconazole
CHEBI:64355
posaconazole
CAS:171228-49-2
ChemIDplus
Drug_Central:3483
DrugCentral
PMID:21762211
Europe PMC
PMID:21967490
Europe PMC
PMID:22058198
Europe PMC
PMID:22176629
Europe PMC
PMID:22215361
Europe PMC
PMID:22215487
Europe PMC
PMID:22286158
Europe PMC
PMID:22290952
Europe PMC
PMID:22303909
Europe PMC
PMID:22324990
Europe PMC
PMID:22330929
Europe PMC
PMID:22380765
Europe PMC
PMID:22391464
Europe PMC
PMID:22391534
Europe PMC
PMID:22427614
Europe PMC
Reaxys:8379448
Reaxys
A neurotransmitter transporter modulator that activates glutamate transporters.
excitatory amino-acid transporter activator
excitatory amino-acid transporter activators
glutamate transporter activators
CHEBI:64370
glutamate transporter activator
A membrane transport modulator that affects the transport of neurotransmitters.
neurotransmitter transporter modulators
CHEBI:64371
neurotransmitter transporter modulator
A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.
phosphatidylcholine
Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine.
Ceramide phosphocholine
sphingomyelin
Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
Wikipedia:Poison
poisonous agent
poisonous agents
poisonous substance
poisonous substances
poisons
toxic agent
toxic agents
toxic substance
toxic substances
CHEBI:64909
poison
Any compound that inhibits cell division (mitosis).
antimitotics
mitosis inhibitor
mitosis inhibitors
mitotic inhibitor
mitotic inhibitors
CHEBI:64911
antimitotic
A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy.
antimycobacterial agent
antimycobacterial agents
antimycobacterial drugs
antimycobacterials
antimycobacterium
CHEBI:64912
antimycobacterial drug
An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria.
antiplasmodial agent
antiplasmodial agents
antiplasmodial drugs
antiplasmodium agent
antiplasmodium agents
antiplasmodium drug
antiplasmodium drugs
CHEBI:64915
antiplasmodial drug
Any protease inhibitor that restricts the action of a serine protease.
serine protease inhibitors
serine proteinase inhibitor
serine proteinase inhibitors
CHEBI:64926
serine protease inhibitor
An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
anti-AIDS agent
anti-AIDS agents
anti-HIV agents
CHEBI:64946
anti-HIV agent
An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
anti-HIV-1 agents
anti-HTLV-III agent
anti-HTLV-III agents
anti-LAV agent
anti-LAV agents
CHEBI:64947
anti-HIV-1 agent
A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
lipoprotein
A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
5-LOX inhibitor
5-LOX inhibitors
5-lipoxygenase inhibitor
5-lipoxygenase inhibitors
5delta-lipoxygenase inhibitor
5delta-lipoxygenase inhibitors
C-5-lipoxygenase inhibitor
C-5-lipoxygenase inhibitors
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitors
EC 1.13.11.34 inhibitor
EC 1.13.11.34 inhibitors
LTA synthase inhibitor
LTA synthase inhibitors
arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitor
arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors
arachidonate 5-lipoxygenase inhibitor
arachidonate 5-lipoxygenase inhibitors
arachidonic 5-lipoxygenase inhibitor
arachidonic 5-lipoxygenase inhibitors
arachidonic acid 5-lipoxygenase inhibitor
arachidonic acid 5-lipoxygenase inhibitors
delta(5)-lipoxygenase inhibitor
delta(5)-lipoxygenase inhibitors
leukotriene A4 synthase inhibitor
leukotriene A4 synthase inhibitors
leukotriene-A4 synthase inhibitor
leukotriene-A4 synthase inhibitors
CHEBI:64964
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
EC 3.1.1.3 (triacylglycerol lipase) inhibitors
EC 3.1.1.3 inhibitor
EC 3.1.1.3 inhibitors
GEH inhibitor
GEH inhibitors
PPL inhibitor
PPL inhibitors
Tween hydrolase inhibitor
Tween hydrolase inhibitors
Tweenase inhibitor
Tweenase inhibitors
Tweenesterase inhibitor
Tweenesterase inhibitors
butyrinase inhibitor
butyrinase inhibitors
cacordase inhibitor
cacordase inhibitors
capalase L inhibitor
capalase L inhibitors
glycerol ester hydrolase inhibitor
glycerol ester hydrolase inhibitors
glycerol-ester hydrolase inhibitor
glycerol-ester hydrolase inhibitors
heparin releasable hepatic lipase inhibitor
heparin releasable hepatic lipase inhibitors
hepatic lipase inhibitor
hepatic lipase inhibitors
hepatic monoacylglycerol acyltransferase inhibitor
hepatic monoacylglycerol acyltransferase inhibitors
lipase inhibitor
lipase inhibitors
lipazin inhibitor
lipazin inhibitors
liver lipase inhibitor
liver lipase inhibitors
pancreatic lipase inhibitor
pancreatic lipase inhibitors
pancreatic triacylglycerol lipase inhibitor
pancreatic triacylglycerol lipase inhibitors
post-heparin plasma protamine-resistant lipase inhibitor
post-heparin plasma protamine-resistant lipase inhibitors
salt-resistant post-heparin lipase inhibitor
salt-resistant post-heparin lipase inhibitors
steapsin inhibitor
steapsin inhibitors
triacetinase inhibitor
triacetinase inhibitors
triacylglycerol ester hydrolase inhibitor
triacylglycerol ester hydrolase inhibitors
triacylglycerol lipase (EC 3.1.1.3) inhibitor
triacylglycerol lipase (EC 3.1.1.3) inhibitors
triacylglycerol lipase inhibitor
triacylglycerol lipase inhibitors
tributyrase inhibitor
tributyrase inhibitors
tributyrin esterase inhibitor
tributyrin esterase inhibitors
tributyrinase inhibitor
tributyrinase inhibitors
triglyceridase inhibitor
triglyceridase inhibitors
triglyceride hydrolase inhibitor
triglyceride hydrolase inhibitors
triglyceride lipase inhibitor
triglyceride lipase inhibitors
triolein hydrolase inhibitor
triolein hydrolase inhibitors
tween-hydrolysing esterase inhibitor
tween-hydrolyzing esterase inhibitors
CHEBI:65001
EC 3.1.1.3 (triacylglycerol lipase) inhibitor
Any compound that has anti-asthmatic effects.
anti-asthmatic agents
antiasthmatic agent
antiasthmatic agents
CHEBI:65023
anti-asthmatic agent
A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.
CAS:192939-46-1
DrugBank:DB04898
Drug_Central:2852
PMID:12846595
PMID:15487959
PMID:16084146
PMID:16106594
PMID:16123912
PMID:16511607
PMID:16767816
PMID:17319469
PMID:17636192
PMID:19028773
PMID:20020269
PMID:28338626
Reaxys:14559655
ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate
Exanta
Exarta
H 376-95
H 376/95
H 37695
ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin-1-yl]- 2-oxo-ethyl]amino]acetate
ximelagatran
ximelagatran (oxime form)
ximelagatranum
CHEBI:65172
ximelagatran
CAS:192939-46-1
ChemIDplus
DrugBank:DB04898
SUBMITTER
Drug_Central:2852
DrugCentral
PMID:12846595
Europe PMC
PMID:15487959
Europe PMC
PMID:16084146
Europe PMC
PMID:16106594
Europe PMC
PMID:16123912
Europe PMC
PMID:16511607
Europe PMC
PMID:16767816
Europe PMC
PMID:17319469
Europe PMC
PMID:17636192
Europe PMC
PMID:19028773
Europe PMC
PMID:20020269
Europe PMC
PMID:28338626
Europe PMC
Reaxys:14559655
Reaxys
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
atypical antipsychotic
atypical antipsychotic agent
atypical antipsychotic agents
atypical antipsychotic drug
atypical antipsychotic drugs
atypical antipsychotics
second generation antipsychotic agent
second generation antipsychotic agents
second generation antipsychotic drug
second generation antipsychotic drugs
second generation antipsychotics
CHEBI:65191
second generation antipsychotic
An antagonist at the vascular endothelial growth factor receptor.
VEGF receptor inhibitor
VEGF receptor inhibitors
VEGFR inhibitor
VEGFR inhibitors
vascular endothelial growth factor receptor antagonists
vascular endothelial growth factor receptor inhibitor
vascular endothelial growth factor receptor inhibitors
CHEBI:65207
vascular endothelial growth factor receptor antagonist
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5).
E thrombin inhibitor
E thrombin inhibitors
EC 3.4.21.5 (thrombin) inhibitors
EC 3.4.21.5 inhibitor
EC 3.4.21.5 inhibitors
activated blood-coagulation factor II inhibitor
activated blood-coagulation factor II inhibitors
beta-thrombin inhibitor
beta-thrombin inhibitors
blood-coagulation factor IIa inhibitor
blood-coagulation factor IIa inhibitors
factor IIa inhibitor
factor IIa inhibitors
fibrinogenase inhibitor
fibrinogenase inhibitors
gamma-thrombin inhibitor
gamma-thrombin inhibitors
thrombase inhibitor
thrombase inhibitors
thrombin (EC 3.4.21.5) inhibitor
thrombin (EC 3.4.21.5) inhibitors
thrombin inhibitor
thrombin inhibitors
thrombin-C inhibitor
thrombin-C inhibitors
thrombofort inhibitor
thrombofort inhibitors
tropostasin inhibitor
tropostasin inhibitors
CHEBI:65232
EC 3.4.21.5 (thrombin) inhibitor
A compound that inhibits the action of gamma-aminobutyric acid.
GABA antagonists
gamma-aminobutyric acid receptor antagonist
gamma-aminobutyric acid receptor antagonists
CHEBI:65259
GABA antagonist
Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
antidyskinesia agents
antidyskinesia drug
antidyskinesia drugs
antidyskinetic agent
antidyskinetic agents
antidyskinetic drug
antidyskinetic drugs
CHEBI:66956
antidyskinesia agent
CHEBI:66987
radiation protective agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
sympatholytic
sympatholytic agents
sympatholytic drug
sympatholytic drugs
sympatholytics
CHEBI:66991
sympatholytic agent
Any compound used to suppress premature labour and immature birth by suppressing uterine contractions.
anti-contraction drug
anti-contraction drugs
anti-contraction medication
anti-contraction medications
labour repressant
labour repressants
tocolytic
tocolytic agents
tocolytic drug
tocolytic drugs
tocolytics
CHEBI:66993
tocolytic agent
A chemosterilant intended to sterilize insects.
insect chemosterilant
insect chemosterilants
insect sterilants
CHEBI:67105
insect sterilant
A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
Wikipedia:Ryanodine_receptor
RyR activator
RyR agonists
ryanodine receptor agonist
An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
CAS:61-68-7
DrugBank:DB00784
Drug_Central:1663
LINCS:LSM-4085
PMID:14001132
PMID:17330662
PMID:22275128
PMID:22369458
PMID:23402341
PMID:23494912
PMID:23656341
PMID:2684858
PMID:28166217
PMID:3304401
PMID:4212650
PMID:425903
PMID:4916242
PMID:5286553
PMID:577447
PMID:6155061
Reaxys:2216243
2-[(2,3-dimethylphenyl)amino]benzoic acid
CI-473
CN 35355
CN-35355
INF 3355
INF-3355
Mefenaminsaeure
N-(2,3-xylyl)-2-aminobenzoic acid
N-2,3-xylylanthranilic acid
Ponstel
acide mefenamique
acido mefenamico
acidum mefenamicum
mefenamic acid
CHEBI:6717
mefenamic acid
CAS:61-68-7
ChemIDplus
CAS:61-68-7
NIST Chemistry WebBook
Drug_Central:1663
DrugCentral
PMID:14001132
Europe PMC
PMID:17330662
Europe PMC
PMID:22275128
Europe PMC
PMID:22369458
Europe PMC
PMID:23402341
Europe PMC
PMID:23494912
Europe PMC
PMID:23656341
Europe PMC
PMID:2684858
Europe PMC
PMID:28166217
Europe PMC
PMID:3304401
Europe PMC
PMID:4212650
Europe PMC
PMID:425903
Europe PMC
PMID:4916242
Europe PMC
PMID:5286553
Europe PMC
PMID:577447
Europe PMC
PMID:6155061
Europe PMC
Reaxys:2216243
Reaxys
An antogonist that interferes with the action of activator protein 1 (AP-1).
AP-1 antagonist
An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-glucosidase (EC 3.2.1.20).
EC 3.2.1.20 (alpha-glucosidase) inhibitors
EC 3.2.1.20 inhibitor
EC 3.2.1.20 inhibitors
alpha-1,4-glucosidase inhibitor
alpha-1,4-glucosidase inhibitors
alpha-D-glucosidase inhibitor
alpha-D-glucosidase inhibitors
alpha-glucopyranosidase inhibitor
alpha-glucopyranosidase inhibitors
alpha-glucosidase (EC 3.2.1.20) inhibitor
alpha-glucosidase (EC 3.2.1.20) inhibitors
alpha-glucosidase inhibitor
alpha-glucosidase inhibitors
alpha-glucoside hydrolase inhibitor
alpha-glucoside hydrolase inhibitors
glucoinvertase inhibitor
glucoinvertase inhibitors
glucosidoinvertase inhibitor
glucosidoinvertase inhibitors
glucosidosucrase inhibitor
glucosidosucrase inhibitors
maltase inhibitor
maltase inhibitors
maltase-glucoamylase inhibitor
maltase-glucoamylase inhibitors
CHEBI:67239
EC 3.2.1.20 (alpha-glucosidase) inhibitor
A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O
DrugBank:DB00814
http://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J22.773K
4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
MLX
meloxicam
A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
Beilstein:4882539
CAS:123318-82-1
DrugBank:DB00631
PMID:19929004
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
clofarabine
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
CAFdA
Cl-F-Ara-A
clofarabina
clofarabine
clofarabinum
CHEBI:681569
clofarabine
Beilstein:4882539
Beilstein
CAS:123318-82-1
ChemIDplus
PMID:19929004
ChEMBL
Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
Type I cell-death inhibitor
apoptosis inhibitor
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Type I cell-death inducer
Type I cell-death inducers
Type I programmed cell-death inducer
Type I programmed cell-death inducers
apoptosis inducers
CHEBI:68495
apoptosis inducer
A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
C8H12O4
CCOC(=O)C=C/C(=O)OCC
CAS:141-05-9
PMID:1471155
PMID:1609410
PMID:3341033
diethyl (2Z)-but-2-enedioate
diethyl malate
A compound which causes a reduction in the levels of glutathione in cells.
glutathione depletion agent role
glutathione depleting agent
An EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor that interferes with the action of dihydroorotate oxidase (fumarate), EC 1.3.98.1 (formerly EC 1.3.3.1).
(S)-dihydroorotate:fumarate oxidoreductase inhibitor
(S)-dihydroorotate:fumarate oxidoreductase inhibitors
DHODH inhibitor
DHODH inhibitors
EC 1.3.3.1 inhibitor
EC 1.3.3.1 inhibitors
EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitor
EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitors
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitors
EC 1.3.98.1 inhibitor
EC 1.3.98.1 inhibitors
dihydroorotate dehydrogenase inhibitor
dihydroorotate dehydrogenase inhibitors
dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitor
dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitors
dihydroorotate oxidase (fumarate) inhibitor
dihydroorotate oxidase (fumarate) inhibitors
CHEBI:68542
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor
A pathway inhibitor that inhibits the synthesis of pyrimidine.
pyrimidine synthesis inhibitors
CHEBI:68543
pyrimidine synthesis inhibitor
An antagonist at the P2Y12 receptor
ADP receptor subtype P2Y12 antagonist
ADP receptor subtype P2Y12 antagonists
P2Y12 receptor antagonists
purinergic receptor subtype P2Y12 antagonist
purinergic receptor subtype P2Y12 antagonists
CHEBI:68563
P2Y12 receptor antagonist
An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
CAS:31828-71-4
DrugBank:DB00379
Drug_Central:1794
LINCS:LSM-1700
PMID:10883344
PMID:11009230
Reaxys:2092205
1-(2,6-dimethylphenoxy)propan-2-amine
Mexiletine
(+-)-1-(2,6-dimethylphenoxy)propan-2-amine
(2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane
1-(2',6'-dimethylphenoxy)-2-aminopropane
1-(2,6-dimethylphenoxy)-2-propanamine
1-methyl-2-(2,6-xylyloxy)ethanamine
mexiletina
mexiletine
mexiletinum
CHEBI:6916
mexiletine
CAS:31828-71-4
ChemIDplus
CAS:31828-71-4
NIST Chemistry WebBook
Drug_Central:1794
DrugCentral
PMID:10883344
Europe PMC
PMID:11009230
Europe PMC
Reaxys:2092205
Reaxys
An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
topoisomerase inhibitors
CHEBI:70727
topoisomerase inhibitor
A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
PPAR-alpha agonist
peroxisome proliferator-activated receptor-alpha agonist
PPARalpha agonist
A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
CAS:444731-52-6
Drug_Central:4118
LINCS:LSM-1114
PMID:21394443
PMID:21766486
PMID:21811833
PMID:22112314
PMID:22190407
PMID:22233389
PMID:22341567
PMID:22359392
PMID:22595799
PMID:22679111
PMID:22688250
PMID:22716487
PMID:22733110
PMID:22733795
PMID:22759480
PMID:22766517
PMID:22830347
PMID:22861374
PMID:22917595
PMID:22984765
PMID:23054212
PMID:23064954
PMID:23072642
PMID:23088634
PMID:23135778
Reaxys:11646488
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
GW 78603
GW786034
pazopanib
pazopanibum
CHEBI:71219
pazopanib
CAS:444731-52-6
ChemIDplus
Drug_Central:4118
DrugCentral
PMID:21394443
Europe PMC
PMID:21766486
Europe PMC
PMID:21811833
Europe PMC
PMID:22112314
Europe PMC
PMID:22190407
Europe PMC
PMID:22233389
Europe PMC
PMID:22341567
Europe PMC
PMID:22359392
Europe PMC
PMID:22595799
Europe PMC
PMID:22679111
Europe PMC
PMID:22688250
Europe PMC
PMID:22716487
Europe PMC
PMID:22733110
Europe PMC
PMID:22733795
Europe PMC
PMID:22759480
Europe PMC
PMID:22766517
Europe PMC
PMID:22830347
Europe PMC
PMID:22861374
Europe PMC
PMID:22917595
Europe PMC
PMID:22984765
Europe PMC
PMID:23054212
Europe PMC
PMID:23064954
Europe PMC
PMID:23072642
Europe PMC
PMID:23088634
Europe PMC
PMID:23135778
Europe PMC
Reaxys:11646488
Reaxys
An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)
EC 2 inhibitor
EC 2 inhibitors
EC 2.* (transferase) inhibitors
EC 2.* inhibitor
EC 2.* inhibitors
transferase inhibitor
transferase inhibitors
CHEBI:71300
EC 2.* (transferase) inhibitor
An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.
CAS:67-20-9
DrugBank:DB00698
Drug_Central:1949
PMID:21567157
PMID:22240115
PMID:22252772
PMID:22252808
PMID:22285235
PMID:22332195
PMID:22508296
PMID:22535452
PMID:22552451
PMID:22722224
PMID:22779302
PMID:22787489
PMID:22836745
PMID:22857139
PMID:22869929
PMID:22876623
PMID:22923965
PMID:22929632
PMID:22977056
PMID:23016316
PMID:23109011
PMID:23113731
PMID:23114172
Reaxys:8132135
1-{[(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione
1-((5-Nitrofurfurylidene)amino)hydantoin
1-(5-Nitro-2-furfurylidenamino)hydantoin
1-(5-Nitro-2-furfurylideneamino)hydantoin
1-[(5-Nitrofurfurylidene)amino]hydantoin
5-Nitrofurantoin
N-(5-Nitrofurfurylidene)-1-aminohydantoin
nitrofurantoin
nitrofurantoina
nitrofurantoine
nitrofurantoinum
CHEBI:71415
nitrofurantoin
CAS:67-20-9
ChemIDplus
CAS:67-20-9
NIST Chemistry WebBook
Drug_Central:1949
DrugCentral
PMID:21567157
Europe PMC
PMID:22240115
Europe PMC
PMID:22252772
Europe PMC
PMID:22252808
Europe PMC
PMID:22285235
Europe PMC
PMID:22332195
Europe PMC
PMID:22508296
Europe PMC
PMID:22535452
Europe PMC
PMID:22552451
Europe PMC
PMID:22722224
Europe PMC
PMID:22779302
Europe PMC
PMID:22787489
Europe PMC
PMID:22836745
Europe PMC
PMID:22857139
Europe PMC
PMID:22869929
Europe PMC
PMID:22876623
Europe PMC
PMID:22923965
Europe PMC
PMID:22929632
Europe PMC
PMID:22977056
Europe PMC
PMID:23016316
Europe PMC
PMID:23109011
Europe PMC
PMID:23113731
Europe PMC
PMID:23114172
Europe PMC
Reaxys:8132135
Reaxys
An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis.
(FAS) inhibitors
EC 2.3.1.85 (fatty acid synthase) inhibitors
EC 2.3.1.85 inhibitor
EC 2.3.1.85 inhibitors
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitor
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitors
fatty acid synthase (EC 2.3.1.85) inhibitor
fatty acid synthase (EC 2.3.1.85) inhibitors
fatty acid synthase inhibitor
fatty acid synthase inhibitors
CHEBI:71476
EC 2.3.1.85 (fatty acid synthase) inhibitor
A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
PPAR-gamma agonist
peroxisome proliferator-activated receptor-gamma agonist
PPARgamma agonist
Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
organic compound
organic molecule
An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
AHR agonist
aryl hydrocarbon receptor agonist
An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
CAS:220991-20-8
DrugBank:DB01283
Drug_Central:1618
PMID:14965322
PMID:15311562
PMID:15456339
PMID:17380211
PMID:19800190
PMID:21688392
PMID:22069133
PMID:22142375
PMID:22621454
PMID:22732767
Reaxys:9784107
{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid
COX 189
COX-189
COX189
Prexige
lumiracoxib
lumiracoxibum
CHEBI:73044
lumiracoxib
CAS:220991-20-8
ChemIDplus
Drug_Central:1618
DrugCentral
PMID:14965322
Europe PMC
PMID:15311562
Europe PMC
PMID:15456339
Europe PMC
PMID:17380211
Europe PMC
PMID:19800190
Europe PMC
PMID:21688392
Europe PMC
PMID:22069133
Europe PMC
PMID:22142375
Europe PMC
PMID:22621454
Europe PMC
PMID:22732767
Europe PMC
Reaxys:9784107
Reaxys
Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*).
EC 3.6 inhibitor
EC 3.6 inhibitors
EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors
EC 3.6.* inhibitor
EC 3.6.* inhibitors
EC 3.6.*.* inhibitor
EC 3.6.*.* inhibitors
acid anhydride hydrolase inhibitor
acid anhydride hydrolase inhibitors
inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)
inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)
CHEBI:73216
EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.
NF-kappaB inhibitors
nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor
nuclear factor kappa-light-chain-enhancer of activated B cells inhibitors
CHEBI:73240
NF-kappaB inhibitor
A carbonyl compound produced as a water-soluble byproduct when fatty acids are broken down for energy in the liver. There are three endogenous ketone bodies: acetone, acetoacetic acid, and (R)-3-hydroxybutyric acid; others may be produced as a result of the metabolism of synthetic triglycerides.
ketone body
An antimetabolite that impairs the action of folic acids
antifolates
folic acid antagonist
folic acid antagonists
CHEBI:73913
antifolate
An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitor
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitors
ADP reductase inhibitor
ADP reductase inhibitors
CDP reductase inhibitor
CDP reductase inhibitors
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitors
EC 1.17.4.1 inhibitor
EC 1.17.4.1 inhibitors
RR inhibitor
RR inhibitors
UDP reductase inhibitor
UDP reductase inhibitors
nucleoside diphosphate reductase inhibitor
nucleoside diphosphate reductase inhibitors
ribonucleoside diphosphate reductase inhibitor
ribonucleoside diphosphate reductase inhibitors
ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor
ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitors
ribonucleoside-diphosphate reductase inhibitor
ribonucleoside-diphosphate reductase inhibitors
ribonucleotide diphosphate reductase inhibitor
ribonucleotide diphosphate reductase inhibitors
ribonucleotide reductase inhibitor
ribonucleotide reductase inhibitors
CHEBI:74213
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
An antagonist at the epidermal growth factor receptor.
EGFR antagonoist
EGFR antagonoists
EGFR inhibitor
EGFR inhibitors
epidermal growth factor receptor antagonists
epidermal growth factor receptor inhibitor
epidermal growth factor receptor inhibitors
CHEBI:74440
epidermal growth factor receptor antagonist
Any substance which is used to reduce or control weight.
anti-obesity agents
anti-obestic agent
anti-obestic agents
CHEBI:74518
anti-obesity agent
A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.
Beilstein:2055849
Beilstein:4690380
CAS:434-22-0
DrugBank:DB00984
Drug_Central:1879
Gmelin:1228044
PMID:11888015
PMID:19055689
PMID:20020363
PMID:24405322
Reaxys:2055849
17beta-hydroxyestr-4-en-3-one
Nandrolone
(17beta)-17-hydroxyestr-4-en-3-one
17beta-hydroxy-19-nor-4-androsten-3-one
17beta-hydroxy-4-estren-3-one
17beta-hydroxyestr-4-en-3-one
19-Norandrostenolone
19-Nortestosterone
4-estren-17beta-ol-3-one
CHEBI:7466
nandrolone
Beilstein:2055849
Beilstein
Beilstein:4690380
Beilstein
CAS:434-22-0
ChemIDplus
Drug_Central:1879
DrugCentral
Gmelin:1228044
Gmelin
PMID:11888015
Europe PMC
PMID:19055689
Europe PMC
PMID:20020363
Europe PMC
PMID:24405322
Europe PMC
Reaxys:2055849
Reaxys
Beilstein:4728403
CAS:83366-66-9
DrugBank:DB01149
Drug_Central:1890
LINCS:LSM-4031
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Nefazodone
nefazodone
1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one
nefazodona
nefazodone
nefazodonum
CHEBI:7494
nefazodone
Beilstein:4728403
Beilstein
CAS:83366-66-9
ChemIDplus
Drug_Central:1890
DrugCentral
An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.
C32H45N3O4S
Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C
nelfinavir
A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
C26H41N3O5
PubChem:462382
C([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)=O)=O)(=O)[H]
Wikipedia:MG132
MG-132
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*).
EC 5.* (isomerase) inhibitors
EC 5.* inhibitor
EC 5.* inhibitors
EC 5.*.*.* inhibitor
EC 5.*.*.* inhibitors
isomerase (EC 5.*) inhibitor
isomerase (EC 5.*) inhibitors
isomerase inhibitor
isomerase inhibitors
CHEBI:75596
EC 5.* (isomerase) inhibitor
Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. (by Wikipedia)
C12H10F3N3O4
CC1(C)NC(=O)N(C1=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
Beilstein:841906
CAS:63612-50-0
DrugBank:DB00665
Drug_Central:1933
LINCS:LSM-2513
Wikipedia:Nilutamide
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
Nilutamide
5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin
Nilandron
nilutamida
nilutamide
nilutamidum
CHEBI:7573
nilutamide
Beilstein:841906
Beilstein
CAS:63612-50-0
ChemIDplus
Drug_Central:1933
DrugCentral
Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
eukaryotic metabolites
CHEBI:75763
eukaryotic metabolite
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
animal metabolites
CHEBI:75767
animal metabolite
Any animal metabolite produced during a metabolic reaction in mammals.
mammalian metabolites
CHEBI:75768
mammalian metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
Mus musculus metabolite
Mus musculus metabolites
mouse metabolites
CHEBI:75771
mouse metabolite
Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
prokaryotic metabolites
CHEBI:75787
prokaryotic metabolite
A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
CAS:51234-28-7
DrugBank:DB04812
Drug_Central:311
PMID:19439485
PMID:19773537
PMID:21128314
PMID:22514582
PMID:23250699
PMID:2413686
PMID:2833969
PMID:2947294
PMID:3981515
PMID:6407402
PMID:6526401
PMID:6645654
PMID:6813936
PMID:6993669
PMID:6993670
PMID:6993671
PMID:6993672
PMID:7044799
PMID:7044801
PMID:7084283
PMID:7084287
PMID:7221526
Reaxys:1085080
2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
(+-)-benoxaprofen
(1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid
2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
DL-benoxaprofen
Lilly 90459
benoxaprofen
benoxaprofene
benoxaprofeno
benoxaprofenum
CHEBI:76114
benoxaprofen
CAS:51234-28-7
ChemIDplus
CAS:51234-28-7
NIST Chemistry WebBook
Drug_Central:311
DrugCentral
PMID:19439485
Europe PMC
PMID:19773537
Europe PMC
PMID:21128314
Europe PMC
PMID:22514582
Europe PMC
PMID:23250699
Europe PMC
PMID:2413686
Europe PMC
PMID:2833969
Europe PMC
PMID:2947294
Europe PMC
PMID:3981515
Europe PMC
PMID:6407402
Europe PMC
PMID:6526401
Europe PMC
PMID:6645654
Europe PMC
PMID:6813936
Europe PMC
PMID:6993669
Europe PMC
PMID:6993670
Europe PMC
PMID:6993671
Europe PMC
PMID:6993672
Europe PMC
PMID:7044799
Europe PMC
PMID:7044801
Europe PMC
PMID:7084283
Europe PMC
PMID:7084287
Europe PMC
PMID:7221526
Europe PMC
Reaxys:1085080
Reaxys
An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
CAS:90101-16-9
Drug_Central:970
PMID:12093490
PMID:1365484
PMID:1365486
PMID:1365487
PMID:1365489
PMID:1365490
PMID:1365491
PMID:1487550
PMID:1507922
PMID:1507923
PMID:1507924
PMID:1545609
PMID:23656309
PMID:2778095
PMID:3110512
PMID:3221746
PMID:3278945
PMID:3489870
PMID:3762266
PMID:8489815
PMID:8492964
PMID:8616003
PMID:8656732
PMID:8983932
Reaxys:6006252
5-methyl-3-(pyridin-2-yl)-2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
droxicam
droxicamum
CHEBI:76133
droxicam
CAS:90101-16-9
ChemIDplus
Drug_Central:970
DrugCentral
PMID:12093490
Europe PMC
PMID:1365484
Europe PMC
PMID:1365486
Europe PMC
PMID:1365487
Europe PMC
PMID:1365489
Europe PMC
PMID:1365490
Europe PMC
PMID:1365491
Europe PMC
PMID:1487550
Europe PMC
PMID:1507922
Europe PMC
PMID:1507923
Europe PMC
PMID:1507924
Europe PMC
PMID:1545609
Europe PMC
PMID:23656309
Europe PMC
PMID:2778095
Europe PMC
PMID:3110512
Europe PMC
PMID:3221746
Europe PMC
PMID:3278945
Europe PMC
PMID:3489870
Europe PMC
PMID:3762266
Europe PMC
PMID:8489815
Europe PMC
PMID:8492964
Europe PMC
PMID:8616003
Europe PMC
PMID:8656732
Europe PMC
PMID:8983932
Europe PMC
Reaxys:6006252
Reaxys
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.
CAS:1553-60-2
Drug_Central:3293
PMID:1479559
PMID:16456879
PMID:21128314
PMID:2585272
PMID:3215965
PMID:5329891
PMID:5657238
PMID:5748163
PMID:5752436
PMID:5807207
PMID:687781
PMID:7587932
PMID:9061203
Reaxys:2046683
(4-isobutylphenyl)acetic acid
[4-(2-methylpropyl)phenyl]acetic acid
(p-Isobutylphenyl)acetic acid
4-(2-Methylpropyl)benzeneacetic acid
4-Isobutylphenylacetic acid
Dytransin
Ibunac
ibufenac
ibufenaco
ibufenacum
CHEBI:76158
ibufenac
CAS:1553-60-2
ChemIDplus
Drug_Central:3293
DrugCentral
PMID:1479559
Europe PMC
PMID:16456879
Europe PMC
PMID:21128314
Europe PMC
PMID:2585272
Europe PMC
PMID:3215965
Europe PMC
PMID:5329891
Europe PMC
PMID:5657238
Europe PMC
PMID:5748163
Europe PMC
PMID:5752436
Europe PMC
PMID:5807207
Europe PMC
PMID:687781
Europe PMC
PMID:7587932
Europe PMC
PMID:9061203
Europe PMC
Reaxys:2046683
Reaxys
Any metabolite produced by metabolism of a xenobiotic compound.
xenobiotic metabolites
CHEBI:76206
xenobiotic metabolite
An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Beilstein:2216786
CAS:72-69-5
DrugBank:DB00540
Drug_Central:1971
LINCS:LSM-4039
PMID:10379421
PMID:14561440
PMID:17071817
PMID:23280809
PMID:24037379
PMID:24368464
PMID:25224004
PMID:25480462
PMID:25569864
PMID:25592638
PMID:25683584
PMID:25707462
PMID:25749306
PMID:26086857
PMID:26453560
Reaxys:2216786
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
Nortriptyline
10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Ateben
Avantyl
Aventyl
Noritren
Psychostyl
Sensaval
demethylamitriptyline
desmethylamitriptyline
nortriptylina
nortriptyline
nortriptylinum
CHEBI:7640
nortriptyline
Beilstein:2216786
ChemIDplus
CAS:72-69-5
ChemIDplus
CAS:72-69-5
NIST Chemistry WebBook
Drug_Central:1971
DrugCentral
PMID:10379421
Europe PMC
PMID:14561440
Europe PMC
PMID:17071817
Europe PMC
PMID:23280809
Europe PMC
PMID:24037379
Europe PMC
PMID:24368464
Europe PMC
PMID:25224004
Europe PMC
PMID:25480462
Europe PMC
PMID:25569864
Europe PMC
PMID:25592638
Europe PMC
PMID:25683584
Europe PMC
PMID:25707462
Europe PMC
PMID:25749306
Europe PMC
PMID:26086857
Europe PMC
PMID:26453560
Europe PMC
Reaxys:2216786
Reaxys
A bridged organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with maleic anhydride followed by hydrolysis of the resulting anhydride. A chemical intermediate used in the preparation of fire-retardant polyester resins and plasticisers.
C9H4Cl6O4
OC(=O)C1C(C(O)=O)C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl
CAS:115-28-6
1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid
Chlorendic Acid
A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*).
C1-transferase (EC 2.1.*) inhibitor
C1-transferase (EC 2.1.*) inhibitors
C1-transferase inhibitor
C1-transferase inhibitors
EC 2.1.* (C1-transferase) inhibitors
EC 2.1.* inhibitor
EC 2.1.* inhibitors
one-carbon-containing group transferase inhibitor
one-carbon-containing group transferase inhibitors
CHEBI:76655
EC 2.1.* (C1-transferase) inhibitor
A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*).
EC 2.3.* (acyltransferase) inhibitors
EC 2.3.* inhibitor
EC 2.3.* inhibitors
acyltransferase inhibitor
acyltransferase inhibitors
CHEBI:76661
EC 2.3.* (acyltransferase) inhibitor
A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*).
EC 2.4.* (glycosyltransferase) inhibitors
EC 2.4.* inhibitor
EC 2.4.* inhibitors
glycosyltransferase (EC 2.4.*) inhibitor
glycosyltransferase (EC 2.4.*) inhibitors
glycosyltransferase inhibitor
glycosyltransferase inhibitors
CHEBI:76662
EC 2.4.* (glycosyltransferase) inhibitor
A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*).
EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors
EC 2.5.1.* inhibitor
EC 2.5.1.* inhibitors
alkyl/aryl (non-methyl) transferase inhibitor
alkyl/aryl (non-methyl) transferase inhibitors
non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor
non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors
non-methyl alkyl/aryl transferase inhibitor
non-methyl alkyl/aryl transferase inhibitors
non-methyl-alkyl or aryl transferase inhibitor
non-methyl-alkyl or aryl transferase inhibitors
CHEBI:76663
EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*).
EC 2.7.* (P-containing group transferase) inhibitors
EC 2.7.* (phosphorus-containing group transferase) inhibitor
EC 2.7.* (phosphorus-containing group transferase) inhibitors
EC 2.7.* inhibitor
EC 2.7.* inhibitors
phosphorus-containing group transferase (EC 2.7.*) inhibitor
phosphorus-containing group transferase (EC 2.7.*) inhibitors
phosphorus-containing group transferase inhibitor
phosphorus-containing group transferase inhibitors
CHEBI:76668
EC 2.7.* (P-containing group transferase) inhibitor
An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*).
EC 5.99.* (miscellaneous isomerases) inhibitor
EC 5.99.* (miscellaneous isomerases) inhibitors
EC 5.99.* (other isomerase) inhibitor
EC 5.99.* (other isomerase) inhibitors
EC 5.99.* (other isomerases) inhibitors
EC 5.99.* inhibitor
EC 5.99.* inhibitors
CHEBI:76697
EC 5.99.* (other isomerases) inhibitor
An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation.
EC 4.* (lyase) inhibitors
EC 4.* inhibitor
EC 4.* inhibitors
EC 4.*.*.* inhibitor
EC 4.*.*.* inhibitors
lyase (EC 4.*) inhibitor
lyase (EC 4.*) inhibitorS
lyase inhibitor
lyase inhibitors
CHEBI:76710
EC 4.* (lyase) inhibitor
A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*).
C-O lyase (EC 4.2.*) inhibitor
C-O lyase (EC 4.2.*) inhibitors
C-O lyase inhibitor
C-O lyase inhibitors
EC 4.2.* (C-O lyase) inhibitors
EC 4.2.* inhibitor
EC 4.2.* inhibitors
CHEBI:76712
EC 4.2.* (C-O lyase) inhibitor
An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).
EC 1.* (oxidoreductase) inhibitors
EC 1.* inhibitor
EC 1.* inhibitors
oxidoreductase (EC 1.*) inhibitor
oxidoreductase (EC 1.*) inhibitors
oxidoreductase inhibitor
oxidoreductase inhibitors
CHEBI:76725
EC 1.* (oxidoreductase) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors
EC 1.1.* inhibitor
EC 1.1.* inhibitors
inhibitor of oxidoreductase acting on CH-OH group of donor
inhibitor of oxidoreductase acting on CH-OH group of donors
inhibitors of oxidoreductase acting on CH-OH group of donor
inhibitors of oxidoreductase acting on CH-OH group of donors
oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor
oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors
oxidoreductase acting on donor CH-OH group inhibitor
oxidoreductase acting on donor CH-OH group inhibitors
CHEBI:76726
EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*).
EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor
EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors
EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors
EC 1.2.* inhibitor
EC 1.2.* inhibitors
inhibitor of oxidoreductase acting on aldehyde or oxo group of donor
inhibitor of oxidoreductase acting on aldehyde or oxo group of donors
inhibitor of oxidoreductase acting on aldehyde/oxo group of donor
inhibitor of oxidoreductase acting on aldehyde/oxo group of donors
inhibitors of oxidoreductase acting on aldehyde or oxo group of donor
inhibitors of oxidoreductase acting on aldehyde or oxo group of donors
inhibitors of oxidoreductase acting on aldehyde/oxo group of donor
inhibitors of oxidoreductase acting on aldehyde/oxo group of donors
oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor
oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors
oxidoreductase acting on donor aldehyde or oxo group inhibitor
oxidoreductase acting on donor aldehyde or oxo group inhibitors
oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor
oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors
oxidoreductase acting on donor aldehyde/oxo group inhibitor
oxidoreductase acting on donor aldehyde/oxo group inhibitors
CHEBI:76727
EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*).
EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors
EC 1.3.* inhibitor
EC 1.3.* inhibitors
inhibitor of oxidoreductase acting on CH-CH group of donor
inhibitor of oxidoreductase acting on CH-CH group of donors
inhibitors of oxidoreductase acting on CH-CH group of donor
inhibitors of oxidoreductase acting on CH-CH group of donors
oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor
oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors
oxidoreductase acting on donor CH-CH group inhibitor
oxidoreductase acting on donor CH-CH group inhibitors
CHEBI:76729
EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*).
EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors
EC 1.5.* inhibitor
EC 1.5.* inhibitors
inhibitor of oxidoreductase acting on CH-NH group of donor
inhibitor of oxidoreductase acting on CH-NH group of donors
inhibitors of oxidoreductase acting on CH-NH group of donor
inhibitors of oxidoreductase acting on CH-NH group of donors
oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor
oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors
CHEBI:76731
EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*).
EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors
inhibitor of oxidoreductase acting on NADH or NADPH
inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
inhibitors of oxidoreductase acting on NADH or NADPH
inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor
oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors
oxidoreductase acting on NADH or NADPH inhibitor
oxidoreductase acting on NADH or NADPH inhibitors
CHEBI:76733
EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors).
EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors
EC 1.8.* inhibitor
EC 1.8.* inhibitors
oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor
oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors
CHEBI:76735
EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on diphenols and related substances as donors (EC 1.10.*.*).
EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitors
EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitor
EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitors
EC 1.10.* inhibitor
EC 1.10.* inhibitors
inhibitor of an oxidoreductase acting on diphenols and related substances as donor
inhibitor of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
inhibitor of an oxidoreductase acting on diphenols and related substances as donors
inhibitors of an oxidoreductase acting on diphenols and related substances as donor
inhibitors of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
inhibitors of an oxidoreductase acting on diphenols and related substances as donors
CHEBI:76737
EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*.
EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors
EC 1.13.* inhibitor
EC 1.13.* inhibitors
oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor
oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors
oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor
oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors
CHEBI:76740
EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*).
EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
EC 1.14.* inhibitor
EC 1.14.* inhibitors
inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor
oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors
oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor
oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors
CHEBI:76741
EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*).
EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors
EC 1.17.* inhibitor
EC 1.17.* inhibitors
oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitor
oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitors
oxidoreductase acting on CH or CH2 inhibitor
oxidoreductase acting on CH or CH2 inhibitors
CHEBI:76744
EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
EC 3.* (hydrolase) inhibitor
EC 3.* (hydrolase) inhibitors
EC 3.* inhibitor
EC 3.* inhibitors
EC 3.*.*.* inhibitor
EC 3.*.*.* inhibitors
hydrolase (EC 3.*) inhibitor
hydrolase (EC 3.*) inhibitors
hydrolase inhibitor
hydrolase inhibitors
CHEBI:76759
Wikipedia:Hydrolase
EC 3.* (hydrolase) inhibitor
A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*).
EC 3.1.* (ester hydrolase) inhibitors
EC 3.1.* inhibitor
EC 3.1.* inhibitors
ester hydrolase (EC 3.1.*) inhibitor
ester hydrolase (EC 3.1.*) inhibitors
ester hydrolase inhibitor
ester hydrolase inhibitors
CHEBI:76760
EC 3.1.* (ester hydrolase) inhibitor
A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*).
EC 3.2.* (glycosylase) inhibitors
EC 3.2.* inhibitor
EC 3.2.* inhibitors
glycosylase (EC 3.2.*) inhibitor
glycosylase (EC 3.2.*) inhibitors
glycosylase inhibitor
glycosylase inhibitors
CHEBI:76761
EC 3.2.* (glycosylase) inhibitor
Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
EC 3.5.* inhibitor
EC 3.5.* inhibitors
CHEBI:76764
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*).
EC 3.1.1.* (carboxylic ester hydrolase) inhibitors
EC 3.1.1.* inhibitor
EC 3.1.1.* inhibitors
carboxylic ester hydrolase (EC 3.1.1.*) inhibitor
carboxylic ester hydrolase (EC 3.1.1.*) inhibitors
CHEBI:76773
EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*).
EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors
EC 3.1.3.* inhibitor
EC 3.1.3.* inhibitors
inhibitor of phosphoric monoester hydrolase
inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)
inhibitors of phosphoric monoester hydrolase
inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)
phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor
phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors
phosphoric monoester hydrolase inhibitor
phosphoric monoester hydrolase inhibitors
CHEBI:76775
EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
EC 3.4.21.26 (prolyl oligopeptidase) inhibitors
EC 3.4.21.26 inhibitor
EC 3.4.21.26 inhibitors
endoprolylpeptidase inhibitor
endoprolylpeptidase inhibitors
post-proline cleaving enzyme inhibitor
post-proline cleaving enzyme inhibitors
post-proline endopeptidase inhibitor
post-proline endopeptidase inhibitors
proline endopeptidase inhibitor
proline endopeptidase inhibitors
proline-specific endopeptidase inhibitor
proline-specific endopeptidase inhibitors
prolyl endopeptidase inhibitor
prolyl endopeptidase inhibitors
prolyl oligopeptidase (EC 3.4.21.26) inhibitor
prolyl oligopeptidase (EC 3.4.21.26) inhibitors
prolyl oligopeptidase inhibitor
CHEBI:76779
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*).
EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors
EC 3.1.26.* inhibitor
EC 3.1.26.* inhibitors
endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitor
endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitors
endoribonuclease producing 5'-phosphomonoesters inhibitor
endoribonuclease producing 5'-phosphomonoesters inhibitors
CHEBI:76785
EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor
An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*).
EC 2.4.2.* (pentosyltransferase) inhibitors
EC 2.4.2.* inhibitor
EC 2.4.2.* inhibitors
pentosyltransferase (EC 2.4.2.*) inhibitor
pentosyltransferase (EC 2.4.2.*) inhibitors
pentosyltransferase inhibitor
pentosyltransferase inhibitors
CHEBI:76790
EC 2.4.2.* (pentosyltransferase) inhibitor
An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of a glutathione transferase (EC 2.5.1.18).
EC 2.5.1.18 (glutathione transferase) inhibitors
EC 2.5.1.18 inhibitor
EC 2.5.1.18 inhibitors
RX:glutathione R-transferase inhibitor
RX:glutathione R-transferase inhibitors
S-(hydroxyalkyl)glutathione lyase inhibitor
S-(hydroxyalkyl)glutathione lyase inhibitors
glutathione S-alkyl transferase inhibitor
glutathione S-alkyl transferase inhibitors
glutathione S-alkyltransferase inhibitor
glutathione S-alkyltransferase inhibitors
glutathione S-aralkyltransferase inhibitor
glutathione S-aralkyltransferase inhibitors
glutathione S-aryltransferase inhibitor
glutathione S-aryltransferase inhibitors
glutathione S-transferase inhibitor
glutathione S-transferase inhibitors
glutathione transferase (EC 2.5.1.18) inhibitor
glutathione transferase (EC 2.5.1.18) inhibitors
glutathione transferase inhibitor
glutathione transferase inhibitors
CHEBI:76797
EC 2.5.1.18 (glutathione transferase) inhibitor
An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
EC 3.5.1.* inhibitor
EC 3.5.1.* inhibitors
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
CHEBI:76807
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of sphingomyelin phosphodiesterase (EC 3.1.4.12).
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor
sphingomyelin phosphodiesterase inhibitor
sphingomyelin phosphodiesterase inhibitor role
An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*).
EC 2.7.11.* (protein-serine/threonine kinase) inhibitors
EC 2.7.11.* inhibitor
EC 2.7.11.* inhibitors
protein-serine/threonine kinase (EC 2.7.11.*) inhibitor
protein-serine/threonine kinase (EC 2.7.11.*) inhibitors
protein-serine/threonine kinase inhibitor
protein-serine/threonine kinase inhibitors
CHEBI:76812
EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*).
EC 2.7.7.* (nucleotidyltransferase) inhibitors
inhibitor of nucleotidyltransferases
inhibitor of nucleotidyltransferases (EC 2.7.7.*)
inhibitors of nucleotidyltransferases
inhibitors of nucleotidyltransferases (EC 2.7.7.*)
nucleotidyltransferase (EC 2.7.7.*) inhibitor
nucleotidyltransferase (EC 2.7.7.*) inhibitors
nucleotidyltransferase inhibitor
nucleotidyltransferase inhibitors
CHEBI:76815
EC 2.7.7.* (nucleotidyltransferase) inhibitor
An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-tyrosine kinase (EC 2.7.10.*).
EC 2.7.10.* (protein-tyrosine kinase) inhibitors
EC 2.7.10.* inhibitor
EC 2.7.10.* inhibitors
protein-tyrosine kinase (EC 2.7.10.*) inhibitor
protein-tyrosine kinase (EC 2.7.10.*) inhibitors
protein-tyrosine kinase inhibitor
protein-tyrosine kinase inhibitors
CHEBI:76817
EC 2.7.10.* (protein-tyrosine kinase) inhibitor
An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class.
EC 5.99.1.* (miscellaneous isomerase) inhibitors
EC 5.99.1.* inhibitor
EC 5.99.1.* inhibitors
CHEBI:76830
EC 5.99.1.* (miscellaneous isomerase) inhibitor
An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*).
EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors
EC 2.5.* inhibitor
EC 2.5.* inhibitors
non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor
non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors
CHEBI:76834
EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*).
EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors
EC 1.1.1.* inhibitor
EC 1.1.1.* inhibitors
oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor
oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors
CHEBI:76835
EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*).
EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors
EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor
EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors
EC 1.13.11.* inhibitor
EC 1.13.11.* inhibitors
oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor
oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors
CHEBI:76837
EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*).
EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
EC 1.14.14.* inhibitor
EC 1.14.14.* inhibitors
oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor
oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors
CHEBI:76838
EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any enzyme in the EC 1.14.99.* (miscellaneous) category.
EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
EC 1.14.99.* inhibitor
EC 1.14.99.* inhibitors
miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor
miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitors
CHEBI:76840
EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*).
EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors
EC 1.14.13.* inhibitor
EC 1.14.13.* inhibitors
oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor
oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors
CHEBI:76841
EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the activity of any such enzyme that uses a disulfide as acceptor (EC 1.17.4.*).
EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitors
EC 1.17.4.* inhibitor
EC 1.17.4.* inhibitors
oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitor
oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors
CHEBI:76848
EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor
An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the function of any such enzyme that uses oxygen as acceptor (EC 1.17.3.*).
EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitors
EC 1.17.3.* inhibitor
EC 1.17.3.* inhibitors
oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitor
oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors
CHEBI:76850
EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor
An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.2.1.*).
EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitors
EC 1.2.1.* inhibitor
EC 1.2.1.* inhibitors
oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitor
oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitors
CHEBI:76852
EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*).
EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors
EC 1.2.3.* inhibitor
EC 1.2.3.* inhibitors
oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor
oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors
CHEBI:76853
EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the function of any such enzyme in the EC 1.3.98.* (with other, known, acceptors) category.
EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor
EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitors
EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitors
EC 1.3.98.* inhibitor
EC 1.3.98.* inhibitors
oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitor
oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitors
CHEBI:76858
EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor
An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*).
EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors
EC 1.5.1.* inhibitor
EC 1.5.1.* inhibitors
oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor
oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors
CHEBI:76863
EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*).
EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors
EC 1.6.5.* inhibitor
EC 1.6.5.* inhibitors
oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor
oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors
CHEBI:76866
EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*).
EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors
EC 1.8.1.* inhibitor
EC 1.8.1.* inhibitors
oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor
oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors
CHEBI:76869
EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
EC 2.1.1.* (methyltransferase) inhibitor
EC 2.1.1.* (methyltransferase) inhibitors
EC 2.1.1.* (methyltransferases) inhibitors
EC 2.1.1.* inhibitor
EC 2.1.1.* inhibitors
methyltransferase (EC 2.1.1.*) inhibitor
methyltransferase (EC 2.1.1.*) inhibitors
CHEBI:76871
EC 2.1.1.* (methyltransferases) inhibitor
An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*).
EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors
EC 2.3.1.* inhibitor
EC 2.3.1.* inhibitors
acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor
acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors
CHEBI:76878
EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*).
EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors
EC 3.6.3.* inhibitor
EC 3.6.3.* inhibitors
acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor
acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors
CHEBI:76895
EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1).
EC 1.14.14.1 (unspecific monooxygenase) inhibitors
EC 1.14.14.1 inhibitor
EC 1.14.14.1 inhibitors
aryl hydrocarbon hydroxylase inhibitor
aryl hydrocarbon hydroxylase inhibitors
aryl-4-monooxygenase inhibitor
aryl-4-monooxygenase inhibitors
flavoprotein monooxygenase inhibitor
flavoprotein monooxygenase inhibitors
flavoprotein-linked monooxygenase inhibitor
flavoprotein-linked monooxygenase inhibitors
microsomal P-450 inhibitor
microsomal P-450 inhibitors
microsomal monooxygenase inhibitor
microsomal monooxygenase inhibitors
substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor
substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors
unspecific monooxygenase (EC 1.14.14.1) inhibitor
unspecific monooxygenase (EC 1.14.14.1) inhibitors
unspecific monooxygenase inhibitor
unspecific monooxygenase inhibitors
xenobiotic monooxygenase inhibitor
xenobiotic monooxygenase inhibitors
CHEBI:76898
EC 1.14.14.1 (unspecific monooxygenase) inhibitor
An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*).
EC 4.2.1.* (hydro-lyase) inhibitor
EC 4.2.1.* (hydro-lyase) inhibitors
EC 4.2.1.* (hydro-lyases) inhibitors
EC 4.2.1.* inhibitor
EC 4.2.1.* inhibitors
hydro-lyase (EC 4.2.1.*) inhibitor
hydro-lyase (EC 4.2.1.*) inhibitors
CHEBI:76907
EC 4.2.1.* (hydro-lyases) inhibitor
An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.
An enzyme inhibitor that interferes with one or more steps in a signaling or metabolic pathway.
metabolic pathway inhibitor
metabolic pathway inhibitors
pathway inhibitors
CHEBI:76932
pathway inhibitor
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
fungal metabolites
CHEBI:76946
fungal metabolite
Any fungal metabolite produced during a metabolic reaction in Penicillium.
Penicillium metabolites
CHEBI:76964
Penicillium metabolite
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
human xenobiotic metabolites
CHEBI:76967
human xenobiotic metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
CHEBI:76969
bacterial metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
E.coli metabolite
E.coli metabolites
Escherichia coli metabolites
CHEBI:76971
Escherichia coli metabolite
An antagonist that binds to and inactivates aryl hydrocarbon receptors (AhRs).
AhR antagonist
AhR receptor antagonist
aryl hydrocarbon receptor antagonist
An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*).
EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors
EC 1.3.5.* inhibitor
EC 1.3.5.* inhibitors
inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor
oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors
CHEBI:77102
EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2.
(S)-dihydroorotate:(acceptor) oxidoreductase inhibitor
(S)-dihydroorotate:(acceptor) oxidoreductase inhibitors
(S)-dihydroorotate:acceptor oxidoreductase inhibitor
(S)-dihydroorotate:acceptor oxidoreductase inhibitors
(S)-dihydroorotate:quinone oxidoreductase inhibitor
(S)-dihydroorotate:quinone oxidoreductase inhibitors
DHOD inhibitor
DHOD inhibitors
DHODH inhibitor
DHODH inhibitors
DHOdehase inhibitor
DHOdehase inhibitors
EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitor
EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitors
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitors
EC 1.3.5.2 inhibitor
EC 1.3.5.2 inhibitors
dihydroorotate:ubiquinone oxidoreductase inhibitor
dihydroorotate:ubiquinone oxidoreductase inhibitors
CHEBI:77103
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor
An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme using a cytochrome as acceptor (EC 1.10.2.*).
EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitors
EC 1.10.2.* inhibitor
EC 1.10.2.* inhibitors
inhibitor of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
inhibitors of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitor
oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitors
CHEBI:77105
EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor
An EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor that interferes with the action of quinol--cytochrome-c reductase (EC 1.10.2.2).
EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitors
EC 1.10.2.2 inhibitor
EC 1.10.2.2 inhibitors
inhibitor of quinol--cytochrome-c reductase (EC 1.10.2.2)
inhibitors of quinol--cytochrome-c reductase (EC 1.10.2.2)
quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitor
quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors
CHEBI:77106
EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).
Wikipedia:IkappaB_kinase
EC 2.7.11.10 (IkappaB kinase) inhibitor
ATP:[IkappaB protein] phosphotransferase inhibitor
IKK inhibitor
IkappaB kinase inhibitor
IkappaB kinase inhibitor
An agonist that selectively binds to and activates androstane receptors.
Wikipedia:Constitutive_androstane_receptor
CAR agonist
constitutive androstane receptor agonist
androstane receptor agonist
An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12).
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
EC 1.8.1.12 inhibitor
EC 1.8.1.12 inhibitors
N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor
N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors
NADPH2:trypanothione oxidoreductase inhibitor
NADPH2:trypanothione oxidoreductase inhibitors
NADPH:trypanothione oxidoreductase inhibitor
NADPH:trypanothione oxidoreductase inhibitors
trypanothione reductase inhibitor
trypanothione reductase inhibitors
trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor
trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors
trypanothione:NADP(+) oxidoreductase inhibitor
trypanothione:NADP(+) oxidoreductase inhibitors
CHEBI:77402
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
A role played by the entity that activates p53.
p53 activator
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
H. sapiens metabolite
H. sapiens metabolites
Homo sapiens metabolite
Homo sapiens metabolites
CHEBI:77746
human metabolite
An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44).
ATP phosphohydrolase (steroid-exporting) inhibitor
ATP phosphohydrolase (steroid-exporting) inhibitors
ATP phosphohydrolase (xenobiotic-exporting) inhibitor
ATP phosphohydrolase (xenobiotic-exporting) inhibitors
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors
EC 3.6.3.44 inhibitor
EC 3.6.3.44 inhibitors
MDR protein inhibitor
MDR protein inhibitors
P-glycoprotein inhibitor
P-glycoprotein inhibitors
PDR protein inhibitor
PDR protein inhibitors
multidrug-resistance protein inhibitor
multidrug-resistance protein inhibitors
pleiotropic-drug-resistance protein inhibitor
pleiotropic-drug-resistance protein inhibitors
steroid-transporting ATPase inhibitor
steroid-transporting ATPase inhibitors
xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor
xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors
xenobiotic-transporting ATPase inhibitor
xenobiotic-transporting ATPase inhibitors
CHEBI:77748
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
Beilstein:5480667
DrugBank:DB00621
Drug_Central:2011
17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
Oxandrolone
oxandrolona
oxandrolone
oxandrolonum
CHEBI:7820
oxandrolone
Beilstein:5480667
Beilstein
Drug_Central:2011
DrugCentral
Any minor or unwanted substance introduced into the environment that can have undesired effects.
environmental contaminants
CHEBI:78298
environmental contaminant
Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).
Alpha-carboxylesterase inhibitor
Alpha-carboxylesterase inhibitors
Beta-esterase inhibitor
Beta-esterase inhibitors
EC 3.1.1.1 (carboxylesterase) inhibitors
ali-esterase inhibitor
ali-esterase inhibitors
butyrate esterase inhibitor
butyrate esterase inhibitors
butyryl esterase inhibitor
butyryl esterase inhibitors
carboxyl ester hydrolase inhibitor
carboxyl ester hydrolase inhibitors
carboxylate esterase inhibitor
carboxylate esterase inhibitors
carboxylesterase inhibitor
carboxylesterase inhibitors
carboxylic acid esterase inhibitor
carboxylic acid esterase inhibitors
carboxylic esterase inhibitor
carboxylic esterase inhibitors
carboxylic-ester hydrolase inhibitor
carboxylic-ester hydrolase inhibitors
cocaine esterase inhibitor
cocaine esterase inhibitors
esterase A inhibitor
esterase A inhibitors
esterase B inhibitor
esterase B inhibitors
esterase D inhibitor
esterase D inhibitors
methylbutyrase inhibitor
methylbutyrase inhibitors
methylbutyrate esterase inhibitor
methylbutyrate esterase inhibitors
monobutyrase inhibitor
monobutyrase inhibitors
nonspecific carboxylesterase inhibitor
nonspecific carboxylesterase inhibitors
procaine esterase inhibitor
procaine esterase inhibitors
propionyl esterase inhibitor
propionyl esterase inhibitors
serine esterase inhibitor
serine esterase inhibitors
triacetin esterase inhibitor
triacetin esterase inhibitors
vitamin A esterase inhibitor
vitamin A esterase inhibitors
CHEBI:78444
EC 3.1.1.1 (carboxylesterase) inhibitor
A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.
CAS:434-07-1
PMID:11071398
PMID:1125426
PMID:11440282
PMID:21860526
Reaxys:2623806
17beta-hydroxy-2-(hydroxymethylidene)-17-methyl-5alpha-androstan-3-one
(5alpha,17beta)-17-hydroxy-2-(hydroxymethylidene)-17-methylandrostan-3-one
17alpha-methyl-2-hydroxymethylene-17-hydroxy-5alpha-androstan-3-one
17beta-hydroxy-2-(hydroxymethylene)-17-methyl-5alpha-androstan-3-one
2-hydroxymethylene-17alpha-methyl-17beta-hydroxy-5alpha-androstan-3-one
2-hydroxymethylene-17alpha-methyl-5alpha-androstan-17beta-ol-3-one
2-hydroxymethylene-17alpha-methyldihydrotestosterone
4,5alpha-dihydro-2-hydroxymethylene-17alpha-methyltestosterone
Adroyd
Anadrol-50
Anapolon
Nastenon
Pardroyd
Plenastril
Protanabol
Synasteron
oximetolona
oxymetholone
oxymetholonum
CHEBI:7864
oxymetholone
CAS:434-07-1
ChemIDplus
CAS:434-07-1
NIST Chemistry WebBook
PMID:11071398
Europe PMC
PMID:1125426
Europe PMC
PMID:11440282
Europe PMC
PMID:21860526
Europe PMC
Reaxys:2623806
Reaxys
A steroid glucosiduronic acid that consists of 17β-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage.
InChIKey:MTKNDAQYHASLID-QXYWQCSFSA-N
Nikkaji:J386.923G
http://purl.bioontology.org/ontology/MESH/C025483
Estradiol-17beta-glucuronide
17β-estradiol 17-glucosiduronic acid
A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
CAS:2152-34-3
DrugBank:DB01230
Drug_Central:2075
LINCS:LSM-5159
PMID:11216184
PMID:2210262
PMID:2303976
PMID:2388127
PMID:4021028
PMID:641739
PMID:772696
Reaxys:151559
2-amino-5-phenyl-1,3-oxazol-4(5H)-one
2-Amino-5-phenyl-4(5H)-oxazolone
2-imino-4-keto-5-phenyltetrahydrooxazole
2-imino-5-phenyl-4-oxazolidinone
5-phenyl-2-imino-4-oxazolidinone
5-phenyl-2-imino-4-oxooxazolidine
5-phenylisohydantion
Azoxodon
Betanamin
Cylert
Dantromin
Deltamine
Hyton
Myamin
Nitan
Notair
pemolina
pemoline
pemolinum
pheniminooxazolidinone
phenylisohydantoin
phenylpseudohydantoin
CHEBI:7953
pemoline
CAS:2152-34-3
ChemIDplus
CAS:2152-34-3
NIST Chemistry WebBook
Drug_Central:2075
DrugCentral
PMID:11216184
Europe PMC
PMID:2210262
Europe PMC
PMID:2303976
Europe PMC
PMID:2388127
Europe PMC
PMID:4021028
Europe PMC
PMID:641739
Europe PMC
PMID:772696
Europe PMC
Reaxys:151559
Reaxys
A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
C12H12N2O3
CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
CAS:50-06-6
CHEBI:8069
DrugBank:DB01174
Open TG-Gates compound_id=00004
https://livertox.nlm.nih.gov//Phenobarbital.htm
phenobarbital
A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Beilstein:384532
CAS:57-41-0
DrugBank:DB00252
Drug_Central:2152
LINCS:LSM-5663
PMID:10698828
PMID:12952753
PMID:15246836
PMID:15744730
PMID:16303054
PMID:7105825
PMID:7602118
PMID:9186244
Reaxys:384532
5,5-diphenylimidazolidine-2,4-dione
5,5-Diphenyl-imidazolidine-2,4-dione
5,5-diphenylimidazolidine-2,4-dione
5,5-diphenyltetrahydro-1H-2,4-imidazoledione
DILANTIN
PHENTYTOIN
fenitoina
phenytoin
phenytoine
phenytoinum
CHEBI:8107
phenytoin
Beilstein:384532
Beilstein
CAS:57-41-0
ChemIDplus
Drug_Central:2152
DrugCentral
PMID:10698828
Europe PMC
PMID:12952753
Europe PMC
PMID:15246836
Europe PMC
PMID:15744730
Europe PMC
PMID:16303054
Europe PMC
PMID:7105825
Europe PMC
PMID:7602118
Europe PMC
PMID:9186244
Europe PMC
Reaxys:384532
Reaxys
An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
crustacean metabolites
CHEBI:83039
crustacean metabolite
A Daphnia metabolite produced by the species Daphnia magna.
Daphnia magna metabolites
CHEBI:83056
Daphnia magna metabolite
A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia
Daphnia metabolites
CHEBI:83057
Daphnia metabolite
Any compound that inhibits the biosynthesis of any sterol.
sterol biosynthesis inhibitors
CHEBI:83317
sterol biosynthesis inhibitor
Any hepatotoxic agent capable of inducing liver steatosis or fatty liver disease.
hepatic steatosis inducing drugs
hepatic steatosis inducing agent
A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
CAS:496775-61-2
Drug_Central:4399
PMID:24433306
PMID:25063763
PMID:25170628
PMID:25400215
PMID:25578417
PMID:25700916
3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid
CHEBI:85010
eltrombopag
CAS:496775-61-2
ChemIDplus
Drug_Central:4399
DrugCentral
PMID:24433306
Europe PMC
PMID:25063763
Europe PMC
PMID:25170628
Europe PMC
PMID:25400215
Europe PMC
PMID:25578417
Europe PMC
PMID:25700916
Europe PMC
An agonist that selectively binds to and activates the thrombopoietin receptor [myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110)].
TPO receptor agonist
TPO receptor agonists
thrombopoietin receptor agonists
CHEBI:85012
thrombopoietin receptor agonist
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
Wikipedia:Antifungal
antifungal drug
Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
agrichemical fungicide
agrichemical fungicides
agrochemical fungicide
agrochemical fungicides
anti-fungal agrichemical
anti-fungal agrichemicals
anti-fungal agrochemical
anti-fungal agrochemicals
antifungal agrichemical
antifungal agrichemicals
antifungal agrochemicals
CHEBI:86328
antifungal agrochemical
Any drug which causes the onset of an allergic reaction.
allergenic drug
CHEBI:88188
drug allergen
Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
PMID:24830781
PMID:25727221
PMID:25793774
PMID:25896709
Wikipedia:Autophagy
autophagocytosis inhibitor
autophagy inhibitor
CAS:1744-22-5
Drug_Central:2382
LINCS:LSM-2471
Riluzole
6-Trifluoromethoxybenzothiazol-2-ylamine
RP-54274
RP54274
rilutek
rilutor
riluzole HCl
riluzole hydrochloride
CHEBI:8863
Riluzole
Drug_Central:2382
DrugCentral
A glycerophosphoglycerol resulting from partial hydrolysis of a phosphatidylglycerol, which removes one of the fatty acid groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.
monoacylglycerophosphoglycerol
lysophosphatidylglycerol
A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
receptor modulators
CHEBI:90710
receptor modulator
An antagonist at purinergic P2 receptors
P2 antagonist
P2 antagonists
non-selective P2 purinergic antagonist
non-selective P2 purinergic antagonists
purinergic receptor P2 antagonists
CHEBI:91079
purinergic receptor P2 antagonist
An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Beilstein:356241
Beilstein:8132868
CAS:599-79-1
DrugBank:DB00795
Gmelin:2666050
PMID:11362329
PMID:11485124
PMID:11587223
PMID:14981898
PMID:15248210
PMID:16322111
PMID:17386570
PMID:2434548
PMID:7720170
Reaxys:8132868
2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
Sulfasalazine
2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid
4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid
5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid
Azulfidine
Salazosulfapiridina
Salazosulfapyridine
Salazosulfapyridinum
Salicylazosulfapyridine
Sulfasalazina
Sulfasalazinum
sulfasalazine
CHEBI:9334
sulfasalazine
Beilstein:356241
Beilstein
Beilstein:8132868
Beilstein
CAS:599-79-1
ChemIDplus
Gmelin:2666050
Gmelin
PMID:11362329
Europe PMC
PMID:11485124
Europe PMC
PMID:11587223
Europe PMC
PMID:14981898
Europe PMC
PMID:15248210
Europe PMC
PMID:16322111
Europe PMC
PMID:17386570
Europe PMC
PMID:2434548
Europe PMC
PMID:7720170
Europe PMC
Reaxys:8132868
Reaxys
A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.
Beilstein:226178
CAS:72-14-0
DrugBank:DB06147
Drug_Central:2527
Gmelin:218965
LINCS:LSM-5327
PMID:11431418
PMID:7486915
Reaxys:226178
4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide
2-(Sulfanilylamino)thiazole
2-(p-Aminobenzenesulfonamido)thiazole
2-(p-Aminobenzenesulphonamido)thiazole
2-Sulfanilamidothiazol
2-Sulfanilamidothiazole
2-Sulfonamidothiazole
4-Amino-N-2-thiazolylbenzenesulfonamide
N(1)-2-Thiazolylsulfanilamide
Sulfanilamidothiazole
Sulfatiazol
Sulphathiazole
sulfathiazol
sulfathiazole
sulfathiazolum
sulfthiazole
CHEBI:9337
sulfathiazole
Beilstein:226178
Beilstein
CAS:72-14-0
ChemIDplus
CAS:72-14-0
NIST Chemistry WebBook
Drug_Central:2527
DrugCentral
Gmelin:218965
Gmelin
PMID:11431418
Europe PMC
PMID:7486915
Europe PMC
Reaxys:226178
Reaxys
A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
CC1=C(CC(O)=O)c2cc(F)ccc2C\1=C/c1ccc(cc1)S(C)=O
ATC:M01AB02
Beilstein:2951842
CAS:38194-50-2
DrugBank:DB00605
Drug_Central:2534
PMID:11569947
PMID:11927004
PMID:12406542
PMID:15020200
PMID:15123337
PMID:19884509
PMID:23689354
PMID:23804703
Reaxys:2951842
Wikipedia:Sulindac
Sulindac
{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
Clinoril
Sulindacum
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
sulindac
sulindaco
CHEBI:9352
sulindac
Beilstein:2951842
Beilstein
CAS:38194-50-2
ChemIDplus
CAS:38194-50-2
NIST Chemistry WebBook
Drug_Central:2534
DrugCentral
PMID:11569947
Europe PMC
PMID:11927004
Europe PMC
PMID:12406542
Europe PMC
PMID:15020200
Europe PMC
PMID:15123337
Europe PMC
PMID:19884509
Europe PMC
PMID:23689354
Europe PMC
PMID:23804703
Europe PMC
Reaxys:2951842
Reaxys
A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.
CAS:91161-71-6
DrugBank:DB00857
Drug_Central:2597
PMID:23750489
PMID:23802806
PMID:23841559
PMID:23895037
PMID:24126579
PMID:24352873
PMID:24389279
PMID:24410098
PMID:24447130
PMID:24452843
PMID:24477462
PMID:24490976
PMID:24497012
PMID:24533442
PMID:24563892
PMID:24576265
PMID:24581620
PMID:24588014
Reaxys:4256376
(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine
terbinafine
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine
terbinafina
terbinafine
terbinafinum
CHEBI:9448
terbinafine
CAS:91161-71-6
ChemIDplus
Drug_Central:2597
DrugCentral
PMID:23750489
Europe PMC
PMID:23802806
Europe PMC
PMID:23841559
Europe PMC
PMID:23895037
Europe PMC
PMID:24126579
Europe PMC
PMID:24352873
Europe PMC
PMID:24389279
Europe PMC
PMID:24410098
Europe PMC
PMID:24447130
Europe PMC
PMID:24452843
Europe PMC
PMID:24477462
Europe PMC
PMID:24490976
Europe PMC
PMID:24497012
Europe PMC
PMID:24533442
Europe PMC
PMID:24563892
Europe PMC
PMID:24576265
Europe PMC
PMID:24581620
Europe PMC
PMID:24588014
Europe PMC
Reaxys:4256376
Reaxys
A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
CAS:96829-58-2
Drug_Central:1996
LINCS:LSM-5724
PMID:27793869
PMID:28097013
PMID:28191026
PMID:28260907
PMID:28387458
PMID:28559211
PMID:28588183
PMID:28624425
Reaxys:3658031
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl N-formyl-L-leucinate
(-)-tetrahydrolipostatin
(2S)-2-formamido-4-methylpentanoic acid [(2S)-1-[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]tridecan-2-yl] ester
Alli
N-formyl-L-leucine (1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl}dodecyl ester
Ro-18-0647
Xenical
orlipastat
orlistat
orlistatum
CHEBI:94686
orlistat
CAS:96829-58-2
ChemIDplus
CAS:96829-58-2
DrugCentral
Drug_Central:1996
DrugCentral
PMID:27793869
Europe PMC
PMID:28097013
Europe PMC
PMID:28191026
Europe PMC
PMID:28260907
Europe PMC
PMID:28387458
Europe PMC
PMID:28559211
Europe PMC
PMID:28588183
Europe PMC
PMID:28624425
Europe PMC
Reaxys:3658031
Reaxys
An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
C34H50O12
[H][C@@]1(OC(=O)C(\C)=C/C)[C@@H](OC(=O)CCCCCCC)[C@@]2([H])C(=C1C)[C@]1([H])OC(=O)[C@@](C)(O)[C@@]1(O)[C@H](C[C@]2(C)OC(C)=O)OC(=O)CCC
CAS:67526-95-8
(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
thapsigargin
A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
CAS:55142-85-3
DrugBank:DB00208
Drug_Central:2657
LINCS:LSM-1986
PMID:19180126
Reaxys:1216802
5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
ticlopidina
ticlopidine
ticlopidinum
CHEBI:9588
ticlopidine
CAS:55142-85-3
ChemIDplus
Drug_Central:2657
DrugCentral
PMID:19180126
Europe PMC
Reaxys:1216802
Reaxys
CAS:127-48-0
Drug_Central:2751
LINCS:LSM-5345
Trimethadione
Tridione (TN)
tridione
trimetadione
trimetin
CHEBI:9727
Trimethadione
CAS:127-48-0
DrugCentral
Drug_Central:2751
DrugCentral
A chromane that has formula C24H27NO5S.
Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. (by Wikipedia)
C24H27NO5S
Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc1ccc(CC2SC(=O)NC2=O)cc1
Wikipedia:Troglitazone
ATC:A10BG01
Beilstein:4338399
CAS:97322-87-7
DrugBank:DB00197
Drug_Central:2767
LINCS:LSM-4890
5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
Troglitazone
(+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
Rezulin (TN)
Romglizone
troglitazona
troglitazone
troglitazonum
CHEBI:9753
troglitazone
Beilstein:4338399
Beilstein
CAS:97322-87-7
ChemIDplus
Drug_Central:2767
DrugCentral
A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
CAS:147059-72-1
DrugBank:DB00685
Drug_Central:2777
PMID:20022474
PMID:20462743
PMID:20538741
PMID:20655887
PMID:21151465
PMID:22305082
PMID:23727874
PMID:24097668
PMID:24525298
Reaxys:8172628
7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
trovafloxacin
trovafloxacine
trovafloxacino
trovafloxacinum
CHEBI:9763
trovafloxacin
CAS:147059-72-1
ChemIDplus
Drug_Central:2777
DrugCentral
PMID:20022474
Europe PMC
PMID:20462743
Europe PMC
PMID:20538741
Europe PMC
PMID:20655887
Europe PMC
PMID:21151465
Europe PMC
PMID:22305082
Europe PMC
PMID:23727874
Europe PMC
PMID:24097668
Europe PMC
PMID:24525298
Europe PMC
Reaxys:8172628
Reaxys
A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
InChIKey:RUDATBOHQWOJDD-UZVSRGJWSA-N
ursodeoxycholic acid
A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
cell line cell
A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
http://purl.bioontology.org/ontology/STY/T025
The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
cell
primary cultured cell
A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged.
primary cultured cell
cultured cell
A cell in vitro that is or has been maintained or propagated as part of a cell culture.
cultured cell
A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.
myoblast
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
BTO:0000452
FMA:63877
fibroblast
epithelial cell
A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
epithelial cell
T cell
A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
T cell
A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
Kupffer cell
A leukocyte with abundant granules in the cytoplasm.
granulocyte
A leukocyte with abundant granules in the cytoplasm.
MESH:D006098
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
BTO:0000830
FMA:66784
mast cell
A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
BTO:0000443
CALOHA:TS-0012
FMA:63880
adipocyte
adipose cell
fat cell
A cell that specializes in controlled release of one or more substances.
BTO:0003659
FMA:86916
secretory cell
insulin secreting cell is a secretory cell and is capable of some insulin secretion
BTO:0000783
insulin secreting cell
Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. A cell that secretes insulin and is located towards the center of the islets of Langerhans.
FMA:70586
ncithesaurus:Beta_Cell
type B pancreatic cell
The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.
hepatocyte
erythrocyte
A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
erythrocyte
A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
platelet
Any cell capable of ingesting particulate matter via phagocytosis.
phagocyte
Any cell capable of ingesting particulate matter via phagocytosis.
ISBN:0721601464
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
macrophage
B cell
A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity.
B cell
Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole.
CALOHA:TS-1119
FMA:83434
white fat cell
A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation.
CALOHA:TS-0099
FMA:83435
brown adipocyte
brown adipose cell
brown fat cell
dendritic cell
A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
dendritic cell
A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
lymphocyte
Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
BTO:0000876
FMA:62864
monocyte
experimentally modified cell in vitro
A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.
experimentally modified cell in vitro
A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver.
Ito cell
hepatic perisinusoidal cell
perisinusoidal cell
hepatic stellate cell
An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
leucocyte
white blood cell
leukocyte
Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
basophil
Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
PMCID:PMC2626675
PMID:11927641
PMID:19741522
PMID:9933081
Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
eosinophil
Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
ISBN:0721601464
PMCID:PMC2626675
PMID:10914487
PMID:1662676
Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
BTO:0000130
CALOHA:TS-0688
FMA:62860
neutrocyte
neutrophil leucocyte
neutrophil leukocyte
neutrophilic leucocyte
neutrophilic leukocyte
neutrophil
Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
ISBN:0721601464
plasma cell
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
http://purl.jp/bio/10/lsd/term/J089510
plasma cell
alpha-beta T cell
A T cell that expresses an alpha-beta T cell receptor complex.
alpha-beta T cell
mononuclear cell
A leukocyte with a single non-segmented nucleus in the mature form.
BTO:0000878
CALOHA:TS-0768
FMA:86713
mononuclear cell
An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.
M1 macrophage
Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
inflammatory macrophage
A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
tissue-resident macrophage
A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.
foam cell
A cell of a hematopoietic lineage.
BTO:0000574
CALOHA:TS-2017
FMA:70366
FMA:83598
haematopoietic cell
haemopoietic cell
hemopoietic cell
hematopoietic cell
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
CALOHA:TS-2096
FMA:63875
connective tissue cell
A Niemann-Pick disease characterized by onset in infancy and involvement of neurological tissues that has_material_basis_in an autosomal recessive mutation of SMPD1 on chromosome 11p15.4.
ICD10CM:E75.2
OMIM:257200
Niemann-Pick disease type A
A Niemann-Pick disease characterized by visceral involvement only and survival into adulthood that has_material_basis_in an autosomal recessive mutation of SMPD1 on chromosome 11p15.4.
ICD10CM:E75.2
OMIM:607616
Niemann-Pick disease type B
A Niemann-Pick disease that has_material_basis_in an autosomal recessive mutation of NPC1 on chromosome 18q11.2.
ICD10CM:E75.2
OMIM:257220
NPC1
Niemann-Pick disease type C1
A Niemann-Pick disease that has_material_basis_in an autosomal recessive mutation of NPC2 on chromosome 14q24.3.
ICD10CM:E75.2
OMIM:607625
NPC2
Niemann-Pick disease type C2
A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells.
Sphingomyelinase Deficiency Disease
lipoid histiocytosis (classical phosphatide)
sphingomyelin lipidosis
Niemann-Pick disease
A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
MESH:D004194
NCI:C2991
SNOMEDCT_US_2016_03_01:64572001
UMLS_CUI:C0012634
disease
A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
MESH:D003920
NCI:C298
diabetes mellitus
A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.
ICD10CM:E11
MESH:D003924
NCI:C26747
SNOMEDCT_US_2018_03_01
NIDDM
non-insulin-dependent diabetes mellitus
type II diabetes mellitus
type 2 diabetes mellitus
A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.
MESH:D003922
OMIM:222100
IDDM
insulin-dependent diabetes mellitus
type I diabetes mellitus
type 1 diabetes mellitus
Substance with antioxidant role is a subtype of substance with role.
This entity is participating in a oxidative stress response and playing an antioxidant role.
substance with antioxidant role
Substance with role is a subtype of object.
This entity is participating in a specific process and playing a role.
In YAMATO ontology theory, an entity (continuant) playing a role in a specific context is called a role holder.
substance with role
Substance with ligand role is a subtype of substance with role.
This entity is participating in signaling and playing a ligand role.
This entity is inferred from Description Logic.
substance with ligand role
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
acyl-CoA or acyl binding
fatty-acyl-CoA binding
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
ISBN:0198506732
A chromosome found in the cytoplasm.
cytoplasmic interphase chromosome
cytoplasmic chromosome
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
mitochondrial proliferation
mitochondrial division
mitochondrial fission
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
PMID:11038192
A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
Wikipedia:M_phase
M phase
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
Wikipedia:Mitophagy
mitochondrion autophagy
autophagy of mitochondrion
Degradation of a mitochondrion by macroautophagy.
PMID:22406072
mitohagy
The selective autophagy process in which a peroxisome is degraded by macroautophagy.
pexophagy
The selective autophagy process in which a peroxisome is degraded by macroautophagy.
PMID:12914914
PMID:16973210
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to hypoxia
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
long-chain fatty acid metabolism
long-chain fatty acid metabolic process
Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
formation of cytoplasmic translation initiation complex
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
cell activation
The expansion of a natural killer cell population by cell division.
natural killer cell proliferation
cytokine production
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
cytokine production
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
PMID:20850011
http://purl.obolibrary.org/obo/HINO_0007325
release of cytochrome c from mitochondria
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
ISBN:0721639976
PMID:12925707
PMID:9560217
PMID:20850011
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process.
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
epithelial to mesenchymal transition
The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
late phagosome biosynthesis
late phagosome formation
phagolysosome formation
phagolysosome assembly
The process in which a precursor cell type acquires the specialized features of a NK T cell.
Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
NK T cell differentiation
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
toll-like receptor signaling pathway
TLR signaling pathway
The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
NK cell mediated immunity
natural killer cell mediated immunity
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
adaptive immune response
cytokine production involved in immune response
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
cytokine production involved in immune response
An immune response taking place in the liver.
hepatic immune response
An immune system process that functions in the response of an organism to a tumor cell.
immune response to tumor cell
The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
leucocyte differentiation
leukocyte differentiation
The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
GO:0002534
cytokine production involved in inflammatory response
Process of any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003677
DNA binding
The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
ketone anabolism
ketone biosynthesis
ketone formation
ketone synthesis
ketone biosynthetic process
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
In the definition of GO:0005488 binding is a subtype of Molecular function.
binding (with molecule)
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
GO:0005504
fatty acid binding
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005515
protein amino acid binding
protein binding
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
GO:0005543
phospholipid binding
cellular component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cellular_component
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Wikipedia:Extracellular
extracellular
Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
extracellular region
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
NIF_Subcellular:sao1425028079
intercellular space
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
ISBN:0198547684
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
Wikipedia:Intracellular
internal to cell
protoplasm
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
ISBN:0198506732
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
NIF_Subcellular:sao1702920020
Wikipedia:Cell_nucleus
cell nucleus
nucleus
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
Wikipedia:Chromosome
chromatid
Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
chromosome
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
ISBN:019857684
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Wikipedia:Cytoplasm
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ISBN:0198547684
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
NIF_Subcellular:sao1860313010
Wikipedia:Mitochondrion
mitochondria
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ISBN:0198506732
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
NIF_Subcellular:sao1289741256
Wikipedia:Outer_mitochondrial_membrane
mitochondrial outer membrane
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
NIF_Subcellular:sao1371347282
Wikipedia:Inner_mitochondrial_membrane
inner mitochondrial membrane
mitochondrial inner membrane
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
mitochondrial respiratory chain complex I
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
https://www.worldcat.org/search?q=bn%3A0198547684
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
mitochondrial respiratory chain complex IV
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
https://www.worldcat.org/search?q=bn%3A0198547684
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
PMID:10751143
Wikipedia:Lysosome
Another function of the ER in eucaryotic cells is to sequester Ca2+ from the cytosol. Cell
lysosome
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
ISBN:0198506732
PMID:10751143
Lysosome-endosome fusion and lysosome biogenesis. lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a hybrid organelle for digestion of endocytosed macromolecules is created.
Lysosomes are then re-formed from hybrid organelles by a process involving condensation of contents.
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosomal membrane
A vacuole to which materials ingested by endocytosis are delivered.
NIF_Subcellular:sao1720343330
Wikipedia:Endosome
endosome
A vacuole to which materials ingested by endocytosis are delivered.
ISBN:0198506732
PMID:19696797
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
PMID:19696797
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
Wikipedia:Vacuole
vacuole
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
ISBN:0198506732
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
autophagosome
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
PMID:11099404
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
peroxisome
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
PMID:9302272
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
ISBN:0815332181
NIF_Subcellular:sao1036339110
Wikipedia:Endoplasmic_reticulum
ER
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
ISBN:0198506732
ISBN:0815332181
The ER has a central role in lipid and protein biosynthesis. Its membrane is the site of production of all the transmembrane proteins and lipids for most of the cell's organelles, including the ER itself, the Golgi apparatus, lysosomes, endosomes, secretory vesicles, and the plasma membrane.
Another function of the ER in eucaryotic cells is to sequester Ca2+ from the cytosol.
The volume enclosed by the membranes of the endoplasmic reticulum.
ER cisterna
ER lumen
endoplasmic reticulum cisterna
endoplasmic reticulum lumen
The lipid bilayer surrounding the endoplasmic reticulum.
ER membrane
endoplasmic reticulum membrane
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
ISBN:0815332181
NIF_Subcellular:sao710427438
Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
The hepatocyte is a cell with an abundant smooth ER.
smooth endoplasmic reticulum
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
ISBN:0198506732
ISBN:0815332181
It is usually prominent in cells that specialize in lipid metabolism.
Cells that synthesize steroid hormones from cholesterol, for example, have an expanded smooth ER compartment to accommodate the enzymes needed to make cholesterol and to modify it to form the hormones.
It is the principal site of production of lipoprotein particles, which carry lipids via the bloodstream to other parts of the body. The enzymes that synthesize the lipid components of lipoproteins are located in the membrane of the smooth ER, which also contains enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and various harmful compounds produced by metabolism.
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
NIF_Subcellular:sao1881364067;
Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
RER
rough ER
rough endoplasmic reticulum
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
ISBN:0198506732
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
NIF_Subcellular:sao451912436
Wikipedia:Golgi_apparatus
Golgi complex
Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
golgi apparatus
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
ISBN:0198506732
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
Golgi lumen
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
Wikipedia:Microtubule_organizing_center
MOC
microtubule organising centre
microtubule organizing center
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
ISBN:0815316194
PMID:17072892
PMID:17245416
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NIF_Subcellular:sao101633890
Wikipedia:Cytosol
cytosol
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
NIF_Subcellular:sao1429207766
Wikipedia:Ribosome
free ribosome
membrane bound ribosome
ribosomal RNA
ribosome
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
ISBN:0198506732
free ribosome
NIF_Subcellular:sao1139385046
membrane bound ribosome
NIF_Subcellular:sao1291545653
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
Wikipedia:Cytoskeleton
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
ISBN:0198547684
PMID:16959967
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins
NIF_Subcellular:sao1663586795
Wikipedia:Cell_membrane
cell membrane
cellular membrane
cytoplasmic membrane
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins
ISBN:0716731363
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Wikipedia:Carbohydrate_metabolism
carbohydrate metabolic process
The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
glycogen metabolic process
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
Reactome:REACT_1736
glycogen anabolism
glycogen biosynthesis
glycogen formation
glycogen synthesis
glycogen biosynthetic process
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
ISBN:0198506732
Reactome:REACT_1736
Glycogen synthesis, Homo sapiens
The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
Reactome:REACT_1008
glycogen breakdown
glycogen catabolism
glycogen degradation
glycogenolysis
glycogen catabolic process
The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
ISBN:0198506732
Reactome:REACT_1008
Glycogen breakdown (glycogenolysis), Homo sapiens
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
alcohol metabolism
alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
CHEBI:30879
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
generation of precursor metabolites and energy
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
Reactome:R-HSA-70263
glucose biosynthesis
glucose biosynthetic process
gluconeogenesis
Reactome:R-HSA-70263
Gluconeogenesis, Homo sapiens
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
glycolytic process
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria.
Reactome: R-HSA-71403.2
Krebs cycle
TCA cycle
Wikipedia:Tricarboxylic_acid_cycle
citric acid cycle
tricarboxylic acid cycle
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
regulation of carbohydrate metabolism
regulation of carbohydrate metabolic process
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
respiratory-chain phosphorylation
oxidative phosphorylation
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
ISBN:0198506732
ISBN:0471331309
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
oxidative phosphorylation, NADH to ubiquinone
complex I (NADH to ubiquinone)
mitochondrial electron transport, NADH to ubiquinone
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
ISBN:0716731363
The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.
mitochondrial electron transport, succinate to coenzyme Q
complex II (succinate to ubiquinone)
oxidative phosphorylation, succinate to ubiquinone
mitochondrial electron transport, succinate to ubiquinone
The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.
ISBN:0716731363
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
complex III (ubiquinone to cytochrome c)
mitochondrial electron transport, ubiquinol to cytochrome c
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
ISBN:0716731363
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA replication
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA repair
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
PMID:11563486
The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.
DNA alkylation
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
DNA methylation
The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
DNA catabolic process
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
PMID:15723341
Apoptosis induced DNA fragmentation
DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
apoptotic DNA fragmentation
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
chromatin remodeling
The cellular synthesis of RNA on a template of DNA.
GO:0006351
http://purl.obolibrary.org/obo/IEV_0000183
DNA-dependent transcription
cellular transcription, DNA-dependent
transcription, DNA-templated
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of cellular transcription, DNA-dependent
regulation of transcription, DNA-templated
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
mRNA cleavage
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
mRNA catabolic process
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
Wikipedia:Translation_(genetics)
translation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
regulation of protein anabolism
regulation of protein biosynthesis
regulation of protein formation
regulation of protein synthesis
regulation of translation
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
PMID:15459659
PMID:15519848
Reactome:R-HSA-391251
Wikipedia:Protein_folding
Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).
protein folding
Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).
R-HSA-391251
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
protein complex formation
protein complex assembly
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
protein acetylation
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
protein deacetylation
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein glycosylation
The covalent attachment of lipid groups to an amino acid in a protein.
lipid:protein modification
protein lipidation
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Wikipedia:Proteolysis
This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.
proteolysis
The removal of sugar residues from a glycosylated protein.
protein deglycosylation
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
amino acid and derivative metabolism
amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolism
cellular amino acid metabolic process
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methionine metabolism
methionine metabolic process
The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
S-adenosylmethionine biosynthetic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
lipid metabolism
lipid metabolic process
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
Wikipedia:Fatty_acid_metabolism
fatty acid metabolism
fatty acid metabolic process
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
ISBN:0198547684
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
MetaCyc:PWY-4381
Wikipedia:Fatty_acid_synthesis
fatty acid anabolism
fatty acid biosynthesis
fatty acid formation
fatty acid synthesis
fatty acid biosynthetic process
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
ISBN:0198506732
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
phospholipid metabolism
biological_process
phospholipid metabolic process
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylethanolamine anabolism
phosphatidylethanolamine biosynthesis
phosphatidylethanolamine formation
phosphatidylethanolamine synthesis
biological_process
phosphatidylethanolamine biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
ISBN:0198506732
The transfer of a phospholipid from its site of synthesis to the plasma membrane.
phospholipid transfer to membrane
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
glycerophospholipid metabolism
phosphoglyceride metabolic process
phosphoglyceride metabolism
alpha-glycerophosphate pathway
glycerophospholipid metabolic process
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidic acid anabolism
phosphatidic acid biosynthesis
phosphatidic acid formation
phosphatidic acid synthesis
phosphatidic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phosphatidylglycerol anabolism
phosphatidylglycerol biosynthesis
phosphatidylglycerol formation
phosphatidylglycerol synthesis
phosphatidylglycerol biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylcholine anabolism
phosphatidylcholine biosynthesis
phosphatidylcholine formation
phosphatidylcholine synthesis
phosphatidylcholine biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
ISBN:0198506732
The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
phosphatidylserine metabolism
biological_process
phosphatidylserine metabolic process
The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
phosphatidylserine anabolism
phosphatidylserine biosyntheis
phosphatidylserine biosynthesis
phosphatidylserine formation
phosphatidylserine synthesis
biological_process
phosphatidylserine biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
phosphatidylserine breakdown
phosphatidylserine catabolism
phosphatidylserine degradation
biological_process
phosphatidylserine catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
Phosphatidylinositol (PI) is synthesized when phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG) followed by conversion into PI and cytidine monophosphate (CMP) (Stuhne-Sekalec et al 1986, Lykidis et al. 1997).
http://purl.obolibrary.org/obo/HINO_0013926
PtdIns biosynthesis
PtdIns biosynthetic process
phosphatidylinositol anabolism
phosphatidylinositol biosynthesis
phosphatidylinositol formation
phosphatidylinositol synthesis
phosphoinositide biosynthesis
phosphoinositide biosynthetic process
phosphatidylinositol biosynthetic process
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
CHEBI:28874
ISBN:0198506732
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
sphingolipid metabolism
sphingolipid metabolic process
The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
sphingomyelin metabolism
biological_process
sphingomyelin metabolic process
The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sphingomyelin breakdown
sphingomyelin catabolism
sphingomyelin degradation
biological_process
sphingomyelin catabolic process
The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sphingomyelin anabolism
sphingomyelin biosynthesis
sphingomyelin formation
sphingomyelin synthesis
sphingomyelin biosynthetic process
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
ISBN:0198506732
The chemical reaction resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
GO:0006695
cholesterol biosynthetic process
The chemical reactions resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid biosynthetic process
The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants
estrogen breakdown
estrogen catabolism
estrogen degradation
estrogen catabolic process
A metabolic process that generates a pool of NADH by the reduction of NAD+.
NAD (reduced) regeneration
reduced NAD regeneration
reduced nicotinamide adenine dinucleotide regeneration
NADH regeneration
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
Reactome:R-HSA-389542
https://reactome.org/PathwayBrowser/#/R-HSA-389542
NADP (reduced) regeneration
reduced NADP regeneration
reduced nicotinamide adenine dinucleotide phosphate regeneration
NADPH regeneration
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle
CHEBI:16856
ISBN:0198506732
glutathione metabolism
glutathione metabolic process
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
GO:0006750
https://reactome.org/PathwayBrowser/#/R-HSA-174403
glutathione anabolism
glutathione biosynthesis
glutathione formation
glutathione synthesis
glutathione biosynthetic process
The chemical reaction resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0006754
ATP anabolism
ATP biosynthesis
ATP formation
ATP synthesis
ATP regeneration
ATP biosynthetic process
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
heme anabolism
heme biosynthesis
heme formation
heme synthesis
heme biosynthetic process
The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
phosphorus metabolic process
phosphorus metabolic process
The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e. g. a xenobiotic chemical, such as a pesticide. (Gene Ontology)
ISBN:0071769234
xenobiotic biotransformation
Xenobiotic biotransformation is metabolic conversion of xenobiotic chemicals to more hydrophilic (water-soluble) compounds.
xenobiotic metabolic process
ISBN:0071769234
Biotransfomation to harmful products is called toxication/metabolic activation [casarett and doull's toxicology 8th ed.]
The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.
transport
The directed movement of charged atoms or small charged molecules into, out of, within or between cells.
ion transport
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
potassium ion transport
The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
neurotransmitter transport
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid transport
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
ISBN:0198506732
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Wikipedia:Endocytosis
endocytosis
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
ISBN:0198506732
ISBN:0716731363
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
Wikipedia:Phagocytosis
phagocytosis
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
ISBN:0198506732
The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.
recognition of phagocytosed substance by phagocytic cell
Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'.
phagocytosis, recognition
The directed movement of molecules between the nucleus and the cytoplasm.
nucleocytoplasmic transport
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation
Wikipedia:Autophagy_(cellular)
autophagy
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation
ISBN:0198547684
PMID:11099404
PMID:9412464
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
IEV:0000070 (obsolete)
Wikipedia:Apoptosis
apoptotic cell death
apoptotic programmed cell death
programmed cell death by apoptosis
apoptotic process
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
cell locomotion
cell movement
movement of a cell
cell motility
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
response to stress
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
immune response
cellular response to DNA damage stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
cellular response to DNA damage stimulus
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to oxidative stress
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
PMID:121115731
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton.
organelle organisation
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
mitochondrion organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
cytoskeleton organisation
cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin filament organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasm organisation
cytoplasm organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
vacuole organization
The directed movement of substances into, out of or within a lysosome.
lysosomal transport
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell cycle
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
arrest of cell cycle progression
cessation of cell cycle
termination of cell cycle
cell cycle arrest
The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.
Wikipedia:Cell_adhesion
cell adhesion
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
EGF receptor signaling pathway
EGFR signaling pathway
epidermal growth factor receptor signaling pathway
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
TGF-beta receptor signaling pathway
transforming growth factor beta receptor signaling pathway
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Notch signaling pathway
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. PMID:12773372
I-kappaB kinase-NF-kappaB signal transduction pathway
I-kappaB kinase/NF-kappaB signaling
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
cytoplasmic sequestering of NF-kappaB
Behavior associated with the intake of food.
Wikipedia:List_of_feeding_behaviours
feeding behavior
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
Wikipedia:Metabolism
metabolism
Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
ISBN:0198547684
The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen metabolic process
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
cell death
The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.
This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
cell proliferation
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
https://reactome.org/PathwayBrowser/#/R-HSA-74752
insulin receptor signalling pathway
insulin receptor signaling pathway
Interacting selectively and non-covalently with a lipid.
lipid binding
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
RNA splicing
Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
GO:0008429
Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylethanolamine binding
Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid anabolism
lipid biosynthesis
lipid formation
lipogenesis
lipid biosynthetic process
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
PMID:21525013
https://reactome.org/PathwayBrowser/#/R-HSA-140534&PATH=R-HSA-5357801,R-HSA-109581,R-HSA-5357769
extrinsic apoptotic signaling pathway via death domain receptors
PMID:21525013
Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84)
The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.
GO:0008643
sugar transport
carbohydrate transport
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
phospholipid anabolism
phospholipid biosynthesis
phospholipid formation
phospholipid synthesis
phospholipid biosynthetic process
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
Wikipedia:Catabolism
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
ISBN:0198547684
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
anabolism
biosynthesis
synthesis
biosynthetic process
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
Wikipedia:Fatty_acid_degradation
fatty acid catabolism
fatty acid degradation
fatty acid catabolic process
The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
vitamin B12 biosynthesis
cobalamin biosynthetic process
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
glycolipid anabolism
glycolipid biosynthesis
glycolipid biosynthetic process
Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. the system requires the presence of a short orf, called a leader peptide, encoded in the mrna upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. the stalled ribosome masks a region of the mrna and affects which of two alternative mrna folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mrna remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.
attenuation of translation
Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. the system requires the presence of a short orf, called a leader peptide, encoded in the mrna upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. the stalled ribosome masks a region of the mrna and affects which of two alternative mrna folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mrna remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.
PMID:15694341
PMID:15805513
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
phospholipid breakdown
phospholipid catabolism
phospholipid degradation
phospholipid catabolic process
The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
toxin metabolism
toxin metabolic process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to environmental stimulus
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to external stimulus
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
response to endogenous stimulus
The infolding of a membrane.
membrane invagination
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Wikipedia:Gene_expression
A changing process to convert a gene's sequenes into a mature gene prduct(s), i.e., (m)RNA, or protein.
gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Wikipedia:Regulation_of_gene_expression
regulation of protein expression
This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
regulation of gene expression
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
proteasome-mediated protein catabolic process
proteasome-mediated protein catabolism
proteasomal protein catabolic process
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of autophagy
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
negative regulation of autophagy
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of autophagy
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
positive regulation of gene expression
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
negative regulation of gene expression
Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
negative regulation of extracellular matrix disassembly
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
macrophage derived foam cell differentiation
Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
regulation of macrophage derived foam cell differentiation
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
positive regulation of macrophage derived foam cell differentiation
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
negative regulation of macrophage derived foam cell differentiation
The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
GO:0010878
cholesterol sequestration
sequestration of cholesterol
cholesterol storage
Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
negative regulation of lipid storage
Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
negative regulation of phosphatidylcholine catabolic process
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. [
regulation of cell death
The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid transport
bile acid and bile salt transport
The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
PMID:12663868
PMID:14699511
Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
canalicular bile acid transport
The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
choline transport
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
drug transport
The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis
fatty acid transport
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
long-chain fatty acid transport
The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
long-chain fatty acid import into peroxisome
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
phospholipid transport
The transport of protons against an electrochemical gradient, using energy from electron transport.
electron transport coupled proton transport
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
Wikipedia:Lipid_catabolism
lipid breakdown
lipid catabolism
lipid degradation
lipolysis
lipid catabolic process
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
cellular growth
growth of cell
cell growth
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
anabolic carbohydrate metabolic process
anabolic carbohydrate metabolism
carbohydrate anabolism
carbohydrate biosynthesis
carbohydrate formation
carbohydrate synthesis
carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
carbohydrate biosynthesis
carbohydrate catabolism
carbohydrate degradation
catabolic carbohydrate metabolic process
catabolic carbohydrate metabolism
carbohydrate catabolic process
The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
ISBN:0198506732
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
vesicle transport
vesicular transport
vesicle trafficking
vesicle-mediated transport
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
endosomal transport
Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.
Reactome:REACT_9509
gap junction assembly
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
EC:2.7.-.-
Wikipedia:Phosphorylation
phosphorylation
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
dephosphorylation
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
Wikipedia:Cell_migration
cell migration
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
protein maturation by peptide bond cleavage
protein processing
The removal of one or more ubiquitin groups from a protein.
protein deubiquitination
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
Wikipedia:SUMO_protein
SUMO-protein conjugation
protein sumolation
sumoylation
protein sumoylation
Interacting selectively and non-covalently with any triester of glycerol.
Interacting selectively and non-covalently with any triester of glycerol.
GO:0017129
triglyceride binding
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
Wikipedia:Drug_metabolism
drug metabolism
drug metabolic process
The covalent attachment of a myristoyl group to a protein.
protein myristoylation
The modification of a protein by amino acid glucuronidation.
glucronide conjugation
protein glucuronidation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
regulation of lipid metabolism
regulation of lipid metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of metabolism
regulation of metabolic process
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
fatty acid oxidation
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
ISBN:0198506732
The chemical reactions and pathways involving a protein. Includes protein modification.
Wikipedia:Protein_metabolism
protein metabolism
protein metabolic process
The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.
glucuronate metabolic process
The rupture of cell membranes and the loss of cytoplasm.
Wikipedia:Cytolysis
cytolysis
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
lipid retention
lipid sequestering
retention of lipids
sequestration of lipid
sequestration of lipids
storage of lipids
lipid storage
One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
cell cycle phase
A process that results in the breakdown of the extracellular matrix.
extracellular matrix disassembly
The aggregation, arrangement and bonding together of a cellular component.
cellular component assembly at cellular level
cellular component assembly
A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
Wikipedia:Electron_transport_chain
electron transport chain
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
Wikipedia:Electron_transfer
electron transfer
respiratory electron transport chain
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
ISBN:0716720094
Any process that modulates the frequency, rate or extent of a signaling process.
regulation of signaling
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
biological signaling (primitive)
signalling (primitive)
Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
signaling [biological] (primitive)
Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
negative regulation of signaling
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
lamellipodium biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin cytoskeleton organization and biogenesis
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
insulin secretion
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
ISBN:0198506732
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
protein repair
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
lymphocyte cell differentiation
lymphocytic blood cell differentiation
lymphocyte development
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
lymphocyte differentiation
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
http://purl.obolibrary.org/obo/IEV_0003880
NK cell activation
natural killer cell activation
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Wikipedia:Cellular_differentiation
cell differentiation
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
Wikipedia:Protein_catabolism
protein breakdown
protein catabolism
protein degradation
This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
protein catabolic process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
extracellular matrix organization
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
T lymphocyte differentiation
T-cell differentiation
T-lymphocyte differentiation
T cell differentiation
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
macrophage cell differentiation
macrophage differentiation
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
ISBN:0781735149
The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.
PMID:10547367
PMID:20083110
autophagy of peroxisome
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cholesterol transport
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ISBN:0198506732
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
negative regulation of transforming growth factor beta receptor signaling pathway
The movement of a leukocyte in response to an external stimulus.
immune cell chemotaxis
leucocyte chemotaxis
leukocyte chemotaxis
The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
GO:0030730
retention of triacylglycerol
retention of triglyceride
sequestering of triacylglycerol
triacylglycerol sequestering
triacylglycerol sequestration
triacylglycerol storage
triglyceride storage
sequestering of triglyceride
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
epithelial cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
PMID:11839751
The post-translational removal of peptide sequences from within a protein sequence.
protein splicing
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
ER unfolded protein response
Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
endoplasmic reticulum unfolded protein response
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
PMID:12042763
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
PMID:11994744
protein retrotranslocation, ER to cytosol
retrograde protein transport, endoplasmic reticulum to cytosol
retrograde protein transport, ER to cytosol
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
PMID:11994744
A structure lying external to one or more cells, which provides structural support for cells or tissues.
MESH:D005109
NCIT:C13232
extracellular matrix
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
intracellular membrane
organelle membrane
A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
PMID:11790549
JNK signal transduction pathway
stress-activated protein kinase signaling cascade
PMID:11790549
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
PtdIns catabolic process
PtdIns catabolism
phosphatidylinositol breakdown
phosphatidylinositol catabolism
phosphatidylinositol degradation
phosphatidylinositol catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
GOC:mah
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
GO:0031210
phosphatidylcholine binding
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
down regulation of protein complex assembly
down-regulation of protein complex assembly
downregulation of protein complex assembly
inhibition of protein complex assembly
negative regulation of protein complex assembly
negative regulation of protein complex assembly
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
actin cytoskeleton remodeling
actin cytoskeleton reorganization
Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.
heat generation
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
TOR signaling cascade
TOR signaling pathway
target of rapamycin signaling pathway
TOR signaling
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
NIF_Subcellular:sao1687101204
nuclear membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
NIF_Subcellular:sao1045389829
mitochondrial membrane
Any small, fluid-filled, spherical organelle enclosed by membrane.
membrane-bounded vesicle
membrane-enclosed vesicle
vesicle
The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.
mitochondrial DNA catabolic process
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
MetaCyc:PWY-5269
diphosphatidylglycerol biosynthesis
diphosphatidylglycerol biosynthetic process
cardiolipin biosynthetic process
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
CHEBI:28494
GOC:mah
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
membrane blebbing
PMID:12083798
PMID:16624291
http://en.wikipedia.org/wiki/Bleb_(cell_biology)
cell blebbing
plasma membrane bleb assembly
bleb assembly
The process in which a methyl group is covalently attached to a molecule.
methylation
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
retrograde transport of endocytic vesicles
endocytic recycling
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
PMID:16473635
chemokine production
The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
chemokine production
type I interferon production
The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
type I interferon production
interferon-gamma production
The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
interferon-gamma production
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
IL-1 beta production
interleukin-1 production
The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
GO:0032612
interleukin-1 production
The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
interleukin-2 production
tumor necrosis factor production
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
TNF alpha production
tumor necrosis factor production
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
Bile contains bile acids, glutathione, phospholipids, cholesterol, bilirubin, and other organic anions, proteins, metals, ions, and xenobiotics.
Hepatocytes begins the formation of bile by transporting bile acids, glutathione, and other solutes including Xenobiotics and their metabolites into the canalicular lumen.
The major driving force of bile formation is the active transport of bile salts and other osmolytes into the canalicular lumen.
Most conjugated bile acids (taurine and glycine conjugates) and some unconjugated bile acids are transported into hepatocytes by sodium-dependent transporters.
Sodium-independent uptake of conjugated and unconjugated bile acids is performed by members of the organic anion-transporting polypeptides (OATPs).
OATPs also transport numerous drugs and hepatotoxicants.
Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.
Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2).
bile acid secretion
transforming growth factor beta1 production
The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
transforming growth factor beta1 production
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
mitochondrial NADH dehydrogenase complex (ubiquinone) assembly
mitochondrial complex I assembly
mitochondrial respiratory chain complex I assembly
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.
mitochondrial respiratory chain complex assembly
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
tumor necrosis factor-mediated signaling pathway
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
cholesterol export
cholesterol efflux
The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.
mitochondrial cytochrome c oxidase biogenesis
mitochondrial cytochrome c oxidase complex assembly
mitochondrial respiratory chain complex IV assembly
The directed movement of a phospholipid out of a cell or organelle.
phospholipid efflux
Any series of molecular signals generated as a consequence of binding to toll-like receptor 4.
toll-like receptor 4 signaling pathway
TLR4 signaling pathway
Any series of molecular signals generated as a consequence of binding to toll-like receptor 9.
toll-like receptor 9 signaling pathway
TLR9 signaling pathway
The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
triacylglycerol transport
triglyceride transport
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
cell junction assembly
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
adherens junction assembly
The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.
very-low-density lipoprotein particle assembly
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
lipid droplet organization
The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
lipid oxidation
The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phosphatidylglycerol breakdown
phosphatidylglycerol catabolism
phosphatidylglycerol degradation
phosphatidylglycerol catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
GOC:mah
The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.
mitochondrial cytochrome bc(1) complex assembly
mitochondrial respiratory chain complex III assembly
The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.
mitochondrial respiratory chain complex II assembly
The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
glutathione transport
The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylcholine breakdown
phosphatidylcholine catabolism
phosphatidylcholine degradation
phosphatidylcholine catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
GOC:jp
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
ER stress response
cellular response to endoplasmic reticulum stress
response to ER stress
response to endoplasmic reticulum stress
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
gene silencing by miRNA
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
PMID:14744438
PMID:15066275
PMID:23209154
Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.
helper T cell enhancement of adaptive immune response
The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.
protein deacylation
A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.
hepatic stellate cell activation
Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
positive regulation of mitochondrial membrane permeability
Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
long-chain fatty acid binding
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
long-chain fatty acyl-CoA binding
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
protein modification process
A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.
Fas signaling pathway
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
UPR signaling by IRE1 stress sensor
endoplasmic reticulum unfolded protein response; IRE1 signaling
IRE1-mediated unfolded protein response
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
PMID:22013210
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
UPR signaling by PERK stress sensor
endoplasmic reticulum unfolded protein response; PERK signaling
PERK-mediated unfolded protein response
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
PMID:22013210
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
activating transcription factor 6 signaling in unfolded protein response
endoplasmic reticulum unfolded protein response; ATF6 signaling
ATF6-mediated unfolded protein response
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
PMID:22013210
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
endoplasmic reticulum-associated degradation
protein degradation by ERAD
ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
ERAD pathway
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
PMID:20940304
PMID:21969857
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
IL-2-mediated signaling pathway
interleukin-2-mediated signaling pathway
A series of molecular signals mediated by CCL2 (C-C chemokine CCL2).
A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
CCL2-activated CCR2 signaling pathway
CCL2 signal transduction pathway
The increase in size or mass of an entire organism, a part of an organism or a cell.
growth
Self-propelled movement of a cell or organism from one location to another.
locomotion
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
regulation of gene expression, epigenetic
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
PMID:10521337
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
PMID:23637286
protein refolding
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
down regulation of epidermal growth factor receptor signaling pathway
negative regulation of EGF receptor signaling pathway
negative regulation of EGF receptor signalling pathway
negative regulation of EGFR signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
cytokine anabolism
cytokine biosynthesis
cytokine formation
cytokine biosynthetic process
The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
ISBN:0198506732
ISBN:0198599471
The expansion of a T cell population by cell division. Follows T cell activation.
T lymphocyte proliferation
T-cell proliferation
T-lymphocyte proliferation
T cell proliferation
The expansion of a T cell population by cell division. Follows T cell activation.
GO:0042098
The expansion of a B cell population by cell division. Follows B cell activation.
B lymphocyte proliferation
B-cell proliferation
B-lymphocyte proliferation
B cell proliferation
The expansion of a B cell population by cell division. Follows B cell activation.
GO:0042100
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T cell activation
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
macrophage polarization
macrophage activation
The chemical reaction resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
lipoprotein anabolism
lipoprotein biosynthesis
lipoprotein biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
negative regulation of protein catabolic process
Any process that results in the repair of damaged RNA.
RNA repair
Tissue regeneration is a subtype of changing material: The regrowth of lost or destroyed tissues.
tissue regeneration
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
hormone metabolism
hormone metabolic process
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
CHEBI:24621
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
microbody
Any biological process involved in the maintenance of an internal steady state.
homeostatic process
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.
ATP synthesis coupled electron transport
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
mitochondrial ATP synthesis coupled electron transport
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
ISBN:0716731363
Any process that modulates the occurrence or rate of cell death by apoptotic process.
Reactome:R-HSA-169911
regulation of apoptotic process
Reactome:R-HSA-169911
http://www.reactome.org/content/detail/REACT_13648
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of apoptotic process
up regulation of apoptosis
up-regulation of apoptosis
upregulation of apoptosis
activation of apoptosis
pro-apoptosis
positive regulation of apoptotic process
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
GO:0043066
anti-apoptosis
down regulation of apoptosis
down-regulation of apoptosis
downregulation of apoptosis
inhibition of apoptosis
negative regulation of apoptosis
pro-survival
negative regulation of apoptotic process
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
proteasome-mediated ubiquitin-dependent protein catabolic process
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
NIF_Subcellular:sao1539965131
Wikipedia:Organelle
organelle
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane-bounded organelle
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle lumen
Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of potassium ion transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of potassium ion transport
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of potassium ion transport
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
An adherent cell-restricted lethal cascade that is ignited by detachment from the matrix and that is characterized by (i) lack of beta1-integrin engagement, (ii) downregulation of EGFR expression, (iii) inhibition of extracellular-regulated kinase 1 (ERK1) signaling, and (iv) overexpression of the BCL-2 family member BIM.
It should be noted that in most, if not all, instances, the cell death program ignited by anoikis is executed by the molecular machinery for intrinsic apoptosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252826/
Wikipedia:Anoikis
anoikis
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
apoptotic cell removal
apoptotic cell clearance
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
PMID:14685684
The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
chaperone-mediated protein transport involved in chaperone-mediated autophagy subClassOf : has_part some protein unfolding
protein unfolding
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.
regulation of generation of precursor metabolites and energy
The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus.
accumulation of pigments
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. PMID:20517722
GO:004349
AKT signaling
protein kinase B signaling
The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.
protein acylation
Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
small molecule metabolic process
Any constituent part of a cell, the basic structural and functional unit of all organisms.
cellular subcomponent
cell part
The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
dendritic cell proliferation
The cell cycle process by which a cell commits to entering the next cell cycle phase.
cell cycle transition
cell cycle phase transition
A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.
cell quiescence
The cell cycle process by which a cell in G2 phase commits to M phase.
cell cycle G2/M phase transition
The cell cycle process by which a cell in G1 phase commits to S phase.
cell cycle G1/S phase transition
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
innate immune response
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
regulation of innate immune response
The covalent attachment of a palmitoleyl group to a protein.
protein palmitoleylation
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
immune cell activation
leucocyte activation
leukocyte activation
The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
adipocyte cell differentiation
adipose cell differentiation
fat cell differentiation
Adipocyte differentiation
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
myoblast cell differentiation
myoblast differentiation
The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
endothelial cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
down regulation of gluconeogenesis
down-regulation of gluconeogenesis
downregulation of gluconeogenesis
negative regulation of gluconeogenesis
Negative regulation of DNA repair is a subtype of negative regulation process: A process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
negative regulation of DNA repair
Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of cell cycle progression
positive regulation of progression through cell cycle
positive regulation of cell cycle
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
negative regulation of endocytosis
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
down regulation of glycolysis
down-regulation of glycolysis
downregulation of glycolysis
negative regulation of glycolytic process
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
positive regulation of proteolysis
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
down regulation of transcription, DNA-dependent
down-regulation of transcription, DNA-dependent
negative regulation of transcription, DNA-templated
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
ATP metabolic process
The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
aflatoxin metabolism
aflatoxin metabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylethanolamine breakdown
phosphatidylethanolamine catabolism
phosphatidylethanolamine degradation
biological_process
phosphatidylethanolamine catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
ISBN:0198506732
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
phosphatidylcholine metabolism
biological_process
phosphatidylcholine metabolic process
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
ISBN:0198506732
The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.
phosphatidylglycerol metabolism
biological_process
phosphatidylglycerol metabolic process
The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.
ISBN:0198506732
The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidic acid metabolism
biological_process
phosphatidic acid metabolic process
The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
glycerophospholipid anabolism
glycerophospholipid biosynthesis
glycerophospholipid formation
glycerophospholipid synthesis
phosphoglyceride biosynthesis
phosphoglyceride biosynthetic process
biological_process
glycerophospholipid biosynthetic process
The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
ISBN:0198506732
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
glycerophospholipid breakdown
glycerophospholipid catabolism
glycerophospholipid degradation
phosphoglyceride catabolic process
phosphoglyceride catabolism
biological_process
glycerophospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
ISBN:0198506732
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
PtdIns metabolic process
PtdIns metabolism
phosphatidylinositol metabolism
phosphoinositide metabolic process
phosphoinositide metabolism
phosphatidylinositol metabolic process
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
CHEBI:28874
ISBN:0198506732
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
ceramide anabolism
ceramide biosynthesis
ceramide formation
ceramide synthesis
ceramide biosynthetic process
The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
catabolosm
ceramide breakedown
ceramide degradation
ceramide catabolic process
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
drug export
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
http://purl.obolibrary.org/obo/IEV_0003879
lymphocyte activation
The expansion of a lymphocyte population by cell division.
lymphocyte proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of the release of insulin.
negative regulation of insulin secretion
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein autophosphorylation
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
positive regulation of lipid biosynthetic process
ketone body biosynthetic process is a subtype of generating: A process that synthesizes ketone body resulting in having output (s).
ketone body biosynthetic process
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
hepatocyte growth factor receptor signaling pathway
HGFR signal transduction pathway
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
Golgi vesicle transport
A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.
pigment granule
Any biological process involved in the maintenance of an internal steady state of a chemical.
chemical homeostasis
The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
cytokine secretion
The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
ISBN:0198599471
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of immune response
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
response to stimulus
The movement of a leukocyte within or between different tissues and organs of the body.
immune cell migration
immune cell trafficking
leucocyte migration
leucocyte trafficking
leukocyte trafficking
leukocyte migration
The movement of a leukocyte within or between different tissues and organs of the body.
ISBN:0781735149
PMID:14680625
PMID:14708592
PMID:7507411
PMID:8600538
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
positive regulation of lipid catabolic process
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of transport (biology)
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
down regulation of lipid biosynthetic process
down-regulation of lipid biosynthetic process
downregulation of lipid biosynthetic process
negative regulation of lipid anabolism
negative regulation of lipid biosynthesis
negative regulation of lipid formation
negative regulation of lipid biosynthetic process
The directed movement of substances out of the nucleus.
export from nucleus
nucleus export
nuclear export
The directed movement of substances out of the nucleus.
GO:0051168
The directed movement of substances into, out of, or within the nucleus.
nucleus transport
nuclear transport
The directed movement of substances into the nucleus.
nuclear import
nucleus import
substance nuclear import
import into nucleus
The process of binding or confining calcium ions such that they are separated from other components of a biological system.
calcium ion (Ca2+) retention
calcium ion (Ca2+) sequestering
calcium ion (Ca2+) sequestration
calcium ion (Ca2+) storage
retention of calcium ion (Ca2+)
sequestering of calcium ion (Ca2+)
storage of calcium ion (Ca2+)
sequestering of calcium ion
The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.
protein polymerization
chromosome organization
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
chromosome organization
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
Wikipedia:Cell_division
http://purl.obolibrary.org/obo/IEV_0003382 (obsolete)
cell division
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
MeSH:D016193
G1 phase
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
MeSH:D016195
PMID:24885854
Wikipedia:G2_phase
Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
G2 phase
The cell cycle phase, following G1, during which DNA synthesis takes place.
MeSH:D016196
S phase
Any process that modulates the rate or extent of progression through the cell cycle.
cell cycle modulation
cell cycle regulation
control of cell cycle progression
modulation of cell cycle progression
regulation of cell cycle progression
regulation of progression through cell cycle
regulation of cell cycle
Any process that activates or increases the frequency, rate or extent of cell division.
up regulation of cell division
positive regulation of cell division
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
negative regulation of AKT signalling cascade
negative regulation of PKB signaling cascade
negative regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion.
xenobiotic glucuronidation
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
endosomal recycling compartment
ERC
endosome recycling compartment
recycling endosome
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
membrane transport
Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
transmembrane transport
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
maintaining phospholipid homeostasis
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
oxidation reduction
oxidoreductase process
oxidation-reduction process
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
Wikipedia:Transdifferentiation
Transdifferentiation
Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
positive regulation of phospholipid catabolic process
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cellular membrane organisation
membrane organization
A cytosolic protein complex that is capable of activating caspase-1.
inflammasome complex
The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.
engulfment of target by autophagosome
The selective autophagy process in which a damaged lysosome is degraded by macroautophagy.
lysophagy
The aggregation, arrangement and bonding together of a set of macromolecules to form a complex.
macromolecular complex assembly
protein-containing complex assembly
The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex.
protein-lipid complex assembly
The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
glycosylation
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
IL-6-mediated signaling pathway
interleukin-6-mediated signalling pathway
interleukin-6-mediated signaling pathway
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
cellular necrosis
Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
necrosis
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
PMID:18846107
PMID:20823910
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
PMID: 21760595
PMID:18846107
PMID:21760595
pyroptosis
PMID: 21760595
The term ‘pyroptosis' has been introduced in 2000 by Brennan and Cookson to functionally describe the peculiar death of macrophages infected by Salmonella typhimurium. Several other bacterial triggers of this atypical cell death modality have been identified, including Shigella flexneri, Listeria monocytogenes, Pseudomonas aeruginosa, Francisella tularensis and the Bacillus anthracis. However, it has become clear that pyroptosis neither constitutes a macrophage-specific process nor a cell death subroutine that only results from bacterial infection. Of note, pyroptotic cells can exhibit apoptotic and/or necrotic morphological features.
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
GO:0070300
phosphatidic acid binding
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
CHEBI:16337
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
IL-1-mediated signaling pathway
interleukin-1-mediated signaling pathway
IL-1 signal transduction pathway
A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein.
protein modification by small protein removal
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
protein modification by small protein conjugation or removal
The process of removing one or more methyl groups from a molecule.
demethylation
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.
positive regulation of phospholipid biosynthetic process
transforming growth factor beta production
The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
transforming growth factor beta production
chemokine (C-C motif) ligand 4 production
The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
chemokine (C-C motif) ligand 4 production
The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
CCL1 production
T cell activation 3 production
TCA-3 production
chemokine (C-C motif) ligand 1 production
tumor necrosis factor superfamily cytokine production
The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
tumor necrosis factor superfamily cytokine production
The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
ER-associated misfolded protein breakdown
ER-associated misfolded protein catabolism
ER-associated misfolded protein degradation
endoplasmic reticulum-associated misfolded protein catabolic process
endoplasmic reticulum-associated misfolded protein catabolism
endoplasmic reticulum-associated degradation
A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
cellular component organization or biogenesis
The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
DNA anabolism
DNA biosynthesis
DNA formation
DNA synthesis
DNA biosynthetic process
A series of molecular signals transduced with the regulation of transcription of target genes by p53.
signal transduction by p53 class mediator
The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
hepatocellular hyperplasia
hepatocyte proliferation
The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
foam cell differentiation
The directed movement of low-density lipoprotein particle from endosomes to lysosomes.
endosome to lysosome transport of LDL
endosome to lysosome transport of low-density lipoprotein particle
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts of an endoplasmic reticulum membrane.
endoplasmic reticulum membrane organization
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
cellular senescence
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
intrinsic apoptotic signaling pathway
The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process.
apoptosome assembly
chemokine (C-X-C motif) ligand 12 production
The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
chemokine (C-X-C motif) ligand 12 production
A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
pmid:25236395
pmid:26794443
feroptosis
Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
detoxification
Any protein complex that is part of the inner mitochondrial membrane.
inner mitochondrial membrane protein complex
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
cellular oxidant detoxification
An infolding of the plasma membrane.
plasma membrane invagination
Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress.
positive regulation of cellular response to oxidative stress
Any process that modulates the frequency, rate or extent of macromitophagy.
regulation of mitophagy
Any process that activates or increases the frequency, rate or extent of mitophagy.
positive regulation of mitophagy
Interacting selectively and non-covalently with fatty acid derivative.
fatty acid derivative binding
Interacting selectively and non-covalently with phosphatidylglycerol.
GO:1901611
phosphatidylglycerol binding
Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
downregulation of signal transduction by p53 class mediator
negative regulation of p53 signaling
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
negative regulation of proteasomal protein catabolic process
Negative regulation of cell junction assembly is a subtype of negative regulation process: Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.
inhibition of cell junction assembly
negative regulation of cell junction assembly
Any DNA replication initiation that is involved in cell cycle DNA replication.
DNA replication initiation involved in cell cycle DNA replication
DNA-dependent DNA replication initiation involved in cell cycle DNA replication
cell cycle DNA replication initiation
Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication.
down regulation of DNA replication involved in S phase
negative regulation of nuclear cell cycle DNA replication
The directed movement of a proton across a membrane.
proton transmembrane transport
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.
negative regulation of mitochondrial electron transport, NADH to ubiquinone
The chemical reaction resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
reactive oxygen species biosynthesis
reactive oxygen species formation
reactive oxygen species synthesis
reactive oxygen species biosynthetic process
reactive oxygen species synthesis
PMID:24252804
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ROS.
negative regulation of reactive oxygen species biosynthetic process
negative regulation of ROS formation
Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly.
negative regulation of gap junction assembly
Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.
positive regulation of glutathione anabolism
positive regulation of glutathione biosynthesis
positive regulation of glutathione formation
positive regulation of glutathione synthesis
up regulation of glutathione anabolism
up regulation of glutathione biosynthesis
positive regulation of glutathione biosynthetic process
Any process that activates or increases the frequency, rate or extent of ERAD pathway.
positive regulation of ERAD
Any process that activates or increases the frequency, rate or extent of protein refolding.
up regulation of protein refolding
up-regulation of protein refolding
upregulation of protein refolding
positive regulation of protein refolding
The orderly movement of a macrophage from one site to another.
macrophage migration
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
cellular detoxification
The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver.
Ito cell proliferation
hepatic perisinusoidal cell proliferation
perisinusoidal cell proliferation
hepatic stellate cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
negative regulation of cellular senescence
As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
Reactome:R-HSA-114294.2
Activation, translocation and oligomerization of BAX
As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
Reactome
tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.
Reactome:R-HSA-114294.2
Activation and oligomerization of BAK protein
Activation of BH3-only proteins
Xenobiotics that contain either a carboxylic group or an aromatic hydroxylamine group are possible substrates for amino acid conjugation. Xenobiotics with a carboxylic group conjugate with an amino group of amino acids such as glycine, taurine and glutamine. The hydroxylamine group conjugates with the carboxylic group of amino acids such as proline and serine.
amino acid conjugation
The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).
PMID:3053703
Reactome: R-HSA-174403.4
Glutathione synthesis and recycling
Reactome: R-HSA-174403.4
https://reactome.org/PathwayBrowser/#/R-HSA-156580&SEL=R-HSA-174403
Transport of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
Translocation of NF-kappaB from the cytosol to the nucleus
A phenotypic abnormality.
Phenotypic abnormality
An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
Dropsy
Fluid retention
Hydrops
Oedema
Water retention
edema
An increased concentration of glucose in the blood.
High blood glucose
High blood sugar
Hyperglycemia
A generically dependent continuant that is about some thing.
information content entity
A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.
measurement datum
GO:0005110
Wnt
GO:0005113
Hh
hedgehog
NCBI-Human-GeneID:6469
NCBI-Mouse-GeneID:20423
NCBI-Rat-GeneID:29499
HHG-1
Sonic hedgehog
SHH (mol)
NCBI-Human-GeneID:6469
https://www.ncbi.nlm.nih.gov/gene/6469
NCBI-Mouse-GeneID:20423
https://www.ncbi.nlm.nih.gov/gene/20423
NCBI-Rat-GeneID:29499
https://www.ncbi.nlm.nih.gov/gene/29499
IL
Interleukin
GO:0005134
Interleukin-2
TCGF
IL-2
GO:0005137
interleukin-5
IL-5
GO:0005138
interleukin-6
IL-6 (mol)
GO:0005149
interleukin-1
IL-1 (mol)
GO:0005135
interleukin-3
IL-3
GO:0005142
interleukin-11
IL-11
Wikipedia:Thrombopoietin
thrombopoietin
TPO
GO:0005128
OMIM: 133170
Wikipedia:Erythropoietin
erythropoietin
EPO
granulocyte colony-stimulating factor
related molecular function GO:0005130
G-CSF
OMIM: 138960
granulocyte-macrophage colony-stimulating factor
relate molecular function GO:0005129
GM-CSF
OMIM: 159540
leukemia inhibitory factor
LIF
OMIM: 184745
Wikipedia:Stem_cell_factor
related molecular function GO:0005173
stem cell factor
SCF
GO:0005164
IPR:006052
TNF superfamily
CD178 antigen
CD95L
Fas ligand
FasL
Tumor necrosis factor ligand superfamily member 6
FasL
GO:0005174
CD154
CD40 ligand
gp39
CD40L
TNF
tumor necrosis factor alpha
TNF alpha
TNF beta
lymphotoxin
lymphotoxin alpha
LT alpha
IFN
Interferon
GO:0005132
type I Interferon
IFN type I
GO:0005133
type II Interferon
IFN type II
GO:0005172
NCBI-Human-GeneID:7422
NCBI-Mouse-GeneID:22339
NCBI-Rat-GeneID:83785
VEGFA
vascular endothelial growth factor
VEGF (mol)
NCBI-Human-GeneID:7422
https://www.ncbi.nlm.nih.gov/gene/7422
NCBI-Mouse-GeneID:22339
https://www.ncbi.nlm.nih.gov/gene/22339
NCBI-Rat-GeneID:83785
https://www.ncbi.nlm.nih.gov/gene/83785
GO:0005161
platelet derived growth factor
PDGF
GO:0005171
hepatocyte growth factor
scatter factor
HGF
GO:0005165
nerve growth factor family
neurotrophin
NGF family
acidic cytokeratin
type I cytokeratin
The TGF-beta superfamily of growth factors regulate many cellular functions, which includes TGF-betas, activins and inhibins, nodal, BMPs and GDFs. TGF-beta/BMP-like proteins are found in various species, including Xenopus, C.elegans and D.melanogaster.
GO:0005160
transforming growth factor beta superfamily
TGF-beta superfamily
The TGF-beta superfamily of growth factors regulate many cellular functions, which includes TGF-betas, activins and inhibins, nodal, BMPs and GDFs. TGF-beta/BMP-like proteins are found in various species, including Xenopus, C.elegans and D.melanogaster.
PMID:12485160
PMID:18000526
PMID:9759503
GO:0016916
inhibin
GO:0016915
activin
BMPs belong to the TGF-beta superfamily. BMP-like molecules have been identified in various species including D.melanogaster (Dpp, Gbb/60A and Scw) and C.elegans.
Bone morphogenetic protein family
BMP family
BMPs belong to the TGF-beta superfamily. BMP-like molecules have been identified in various species including D.melanogaster (Dpp, Gbb/60A and Scw) and C.elegans.
PMID:15871923
PMID:9720756
PMID:9759503
GO:0005160
TGF-beta family
GO:0005160
transforming growth factor-beta 1
TGF-beta1
GO:0005160
transforming growth factor-beta 2
TGF-beta2
GO:0005160
transforming growth factor-beta 3
TGF-beta3
GO:0005160
Glial cell line-derived neurotrophic factor
GDNF
Nodal family
epidermal growth factor family
EGF family
NRG
neuregulin
GO:0005104
Fibroblast growth factor
HBGF
Heparin-binding growth factor
FGF
neutral to basic cytokeratin
type II cytokeratin
leptin
A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus.
IMR:0010309
IMR:0011543
IMR:0011922
GO:0016088
MeSH:D007328
Humulin
Insulin precursor
insulin A chain
insulin B chain
insulin fragments
insulin
A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus.
MeSH:D007328
cytokeratin 1
GO:0005027
tumor necrosis factor receptor family
TNFR family
GO:0005028
CD40
Apo-1
CD95
Fas receptor
FasR
GO:0005032
tumor necrosis factor receptor, type I
TNFR1
GO:0005033
tumor necrosis factor receptor, type II
TNFR2
GO:0005017
platelet derived growth factor receptor
PDGF receptor
GO:0005018
alpha platelet derived growth factor receptor
alpha PDGF receptor
GO:0005019
beta platelet derived growth factor receptor
beta PDGF receptor
insulin receptor family
anaplastic lymphoma kinase
ALK
leukocyte tyrosine kinase
LTK
IMR:0010308
IMR:0011304
IMR:0011542
GO:0005009
CD220 antigen
IR
insulin receptor alpha subunit
insulin receptor beta subunit
insulin receptor precursor
insulin receptor
The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4.
GO:0005007
fibroblast growth factor receptor
FGFR family
The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4.
PMID:15689573
GO:0005006
epidermal growth factor receptor
EGFR (mol)
GO:0008095
IP3R
inositol-1,4,5-triphosphate receptor
IP3 receptor
GO:0004887
c-erbA
thyroid hormone receptor
TR
cytokeratin 3
Estrogen receptor
transcription factors that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
http://purl.bioontology.org/ontology/MESH/D047492
Peroxisome proliferator activated receptor
PPAR
Retinoic acid receptor
RAR
GO:0005024
Transforming growth factor-beta receptor
TGF-beta receptor
GO:0005025
Transforming growth factor-beta receptor type I
TGF-beta receptor type I
GO:0005026
Transforming growth factor-beta receptor type II
TGF-beta receptor type II
GO:0004907
interleukin receptor
GO:0004911
interleukin-2 receptor
IL-2 receptor
GO:0004914
interleukin-5 receptor
IL-5 receptor
GO:0004915
interleukin-6 receptor
IL-6 receptor
GO:0004913
interleukin-4 receptor
IL-4 receptor
GO:0004912
interleukin-3 receptor
IL-3 receptor
GO:0004917
interleukin-7 receptor
IL-7 receptor
GO:0004919
interleukin-9 receptor
IL-9 receptor
GO:0016515
interleukin-13 receptor
IL-13 receptor
GO:0042010
interleukin-15 receptor
IL-15 receptor
GO:0004908
interleukin-1 receptor
IL-1 receptor
GO:0042008
IL-1Rrp
IL1 receptor-related protein
Interleukin-18 receptor
IL-18 receptor
Toll-like receptor
TLR
OB-R
leptin receptor
GO:0004904
interferon receptor
IFNR
GO:0004905
IFNAR
Interferon alpha/beta receptor
IFNR type I
GO:0004906
IFNGR
Interferon-gamma receptor
IFNR type II
GO:0042611
major histocompatibility complex
MHC family
MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin.
GO:0042612
MHC class Ia molecule
classical MHC class I molecule
major histocompatibility complex class I molecule
MHC class I molecule
MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin.
ISBN:0815340729
PMID:10607669
PMID:16860610
MHC class II molecules are composed of membrane-spanning alpha and beta chains.
GO:0042613
classical MHC class II molecule
major histocompatibility complex class II molecule
MHC class II molecule
MHC class II molecules are composed of membrane-spanning alpha and beta chains.
ISBN:0815340729
PMID:10607669
cytokeratin 4
T-cell receptor
TCR family
GO:0019815
B cell receptor
B cell receptor complex
B-cell antigen receptor
BCR complex
BCR
FcR
FcepsilonRI
High affinity immunoglobulin gamma Fc receptor I
FcgammaRI
Low affinity immunoglobulin gamma FC region receptor III
FcgammaRIII
Low affinity immunoglobulin gamma Fc region receptor II
FcgammaRII
cytokeratin 5
cytokeratin 7
cytokeratin 8
IMR:0000260
cytokeratin 6D
cytokeratin 6A
cadherin
Arc-1
Epithelial-cadherin
L-CAM
Uvomorulin
cadherin-1
cell-CAM120/80
E-cadherin
A-CAM
Neural-cadherin
cadherin-2
N-cadherin
Retinal-cadherin
cadherin-4
R-cadherin
Vascular endothelial-cadherin
cadherin-5
VE-cadherin
Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties.
integrin
Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties.
PMID:10446041
Integrin alpha
Integrin beta
alpha-catenin
named 'beta-catenin family' formerly.
beta-catenin
intercellular adhesion molecule
ICAM
neuronal cell adhesion molecule
N-CAM
paxillin
A role played by the protein contributes to the integrity of the actin cytoskeleton.
IMR:0000188 (obsolete)
actin filament cytoskeletal protein
related cellular component GO:0015629
actin cytoskeleton protein
alpha-actinin
actin
myosin
tropomyosin
troponin
kinesin
dynein
cytokeratin
keratin
GO:0005883
neurofilament protein
dystrophin
Adenomatous Polyposis Coli Protein
APC
ankyrin
IMR:0000302
cytokeratin 6F
cytokeratin 6B
MeSH:D019061
Src family
C-terminal Src kinase
Csk
Janus kinases (Jaks) are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). In Drosophila there is only one Jak kinase, Hopscotch (Hop).
GO:0004718
Janus kinase
JAK
Janus kinases (Jaks) are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). In Drosophila there is only one Jak kinase, Hopscotch (Hop).
PMID:15575979
Fak/Pyk2
GO:0004717
Focal adhesion kinase
Fak
CADTK
Cak beta
RAFTK
calcium-dependent tyrosine kinase
cell adhesion kinase beta
prolin-rich tyrosine kinase 2
related adhesion focal tyrosine kinase
Pyk2
ZAP-70/Syk
ZAP-70
Spleen tyrosine kinase
Syk
Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif.
GO:0004707
IPR:003527
MAP kinase
mitogen-activated protein kinase
MAPK
Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif.
PMID:11242034
PMID:9922370
GO:0016909
IPR:008351
c-jun N-terminal kinase
stress-activated protein kinase
JNK/SAPK
IPR:008352
p38
ERK1 and ERK2 are isoforms of the 'classical' MAPK. Both ERK1 and ERK2 (referred to as ERK1/2) are activated by MAP/ERK kinase 1 (MEK1) and MEK2 (referred to as MEK1/2). MEK1/2 phosphorylates threonine and tyrosine residues in the Thr-Glu-Tyr (TEY) sequence of ERK1/2. Activated ERK1/2 phosphorylates many substrates including transcription factors, such as Elk1 and c-Myc, and protein kinases, such as ribosomal S6 kinase (RSK).
IPR:008349
ERK
Extracellular signal-regulated kinase
MAPK/ERK
p42/p44 MAP kinase
p42/p44 MAPK
ERK1/2
ERK1 and ERK2 are isoforms of the 'classical' MAPK. Both ERK1 and ERK2 (referred to as ERK1/2) are activated by MAP/ERK kinase 1 (MEK1) and MEK2 (referred to as MEK1/2). MEK1/2 phosphorylates threonine and tyrosine residues in the Thr-Glu-Tyr (TEY) sequence of ERK1/2. Activated ERK1/2 phosphorylates many substrates including transcription factors, such as Elk1 and c-Myc, and protein kinases, such as ribosomal S6 kinase (RSK).
PMID:16880823
GO:0004709
MAP kinase kinase kinase
MAPKK kinase
MKKK
MAPKKK
c-mos
mos
Raf
MOM-4
TGF-bata activated kinase 1
TAK1
Cot
Est
Tumor progression locus 2
cancer Osaka thyroid oncogene
Tpl2
GO:0004710
MAPK/ERK kinase kinase
MEKK
PAK
MLK family
GO:0004704
NF-kappa B-inducing kinase
NIK
GO:0008385
I-kappaB kinase complex
IKK complex
IMR:0000270
cytokeratin 6E
cytokeratin 6C
GO:0004697
protein kinase C
PKC
novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids.
novel protein kinase C
nPKC
novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids.
PMID:15282562
atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG.
GO:0004700
atypical protein kinase C
aPKC
atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG.
PMID:15282562
A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway.
GO:0004711
90 kDa ribosomal S6 kinase
MAPK-activated protein kinase-1
MAPKAP kinase-1
MAPKAP-K1
p90rsk
RSK
A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway.
PMID:10411321
PKA is comprised of two types of subunits. Two catalytic (C) subunits bind to a regulatory (R) subunit dimer to form an inactive holoenzyme complex. Binding of cAMP to the regulatory subunit causes the catalytic subunit to be unleashed.
GO:0004691
GO:0005952
cAMP-dependent protein kinase
protein kinase A
PKA
PKA is comprised of two types of subunits. Two catalytic (C) subunits bind to a regulatory (R) subunit dimer to form an inactive holoenzyme complex. Binding of cAMP to the regulatory subunit causes the catalytic subunit to be unleashed.
PMID:17996741
PKB
RAC serine/threonine protein kinase
RAC-PK
protein kinase B
Akt
GO:0004692
cGMP-dependent protein kinase
PKG
Ste20 homolog family
mammalian Ste20-like kinases (MAPKKKK)
G-protein coupled receptor kinase
IMR:0010402
3-phosphoinositide dependent protein kinase-1
hPDK1
phosphatidylinositol-dependent kinase
PDK
polo-like kinase
Plk
GO:0004696
glycogen synthase kinase 3
GSK3
GO:0004708
MAP kinase kinase
MAPK kinase
MAPKK
MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases.
MAPKK1/2
MEK
MEK1/2
MKK1/2
MEK1/2(MKK1/2)
MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases.
PMID:11242034
PMID:9922370
MKK4 and MKK7 phosphorylate and activate JNK MAP kinases.
MKK4/7(JNKK1/2)
MKK4 and MKK7 phosphorylate and activate JNK MAP kinases.
PMID:11242034
PMID:9922370
MKK3 and MKK6 phosphorylate and activate p38 MAP kinases.
MKK3/6
MKK3 and MKK6 phosphorylate and activate p38 MAP kinases.
PMID:11242034
PMID:9922370
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
GO:0016303
PI3K
phosphatidylinositol 3-kinase
PI3-kinase
Phosphatidylinositol 3-kinase p85 regulatory subunit
PI3-kinase p85 subunit
Phosphatidylinositol 3-kinase p110 catalytic subunit
PI3-kinase p110 subunit
Receptor interacting protein
Receptor-interacting serine/threonine protein kinase
RIP
Src homology-2 domain-containing inositol 5'-phosphatase
SHIP
SHP family
HCP
PTP1C
SH-PTP1
Src homology 2-containing protein tyrosine phosphatase-1
SHP-1
PTP1D
SH-PTP2
Src homology 2-containing protein tyrosine phosphatase-2
Syp
SHP-2
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
EC:3.1.1.4
GO:0004623
PMID:30077006
phospholipase A2
PLA2 (mol)
EC:3.1.4.11
GO:0004629
phospholipase C
PLC (mol)
MeSH: D051966
phospholipase C gamma
PLC gamma
phospholipase C beta
PLCbeta
EC:3.1.4.4
GO:0004630
phospholipase D
PLD
IPR:003577
Ras family
Ras GTPase
Ras
NCBI-Human-GeneID:3845
NCBI-Mouse-GeneID:16653
NCBI-Rat-GeneID:24525
K-Ras
Ki-ras
KRAS (mol)
NCBI-Human-GeneID:3845
https://www.ncbi.nlm.nih.gov/gene/3845
NCBI-Mouse-GeneID:16653
https://www.ncbi.nlm.nih.gov/gene/16653
NCBI-Rat-GeneID:24525
https://www.ncbi.nlm.nih.gov/gene/24525
related to Ras
R-Ras
Ras-like
Ral
Ras proximal
Rap
IPR:003578
Rho family
Rho
Rac
IPR:003579
Ras genes from rat brain
Rab
IPR:002041
Ras-like nuclear protein
TC4
Ran
Arf/Sar
EC:3.4.-.-
GO:0008233
peptidase
protease
GO:0030693
caspase (family)
effector caspase
signaling (initiator) caspase
The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins.
GO:0000502
26S proteasome
The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins.
PMID:10872471
PMID:9228274
PMID:9647729
EC:3.6.5.1
G-protein, alpha subunit
Guanine nucleotide-binding protein, alpha subunit
G-alpha
G-alpha-s class
G-alpha-i class
G-alpha-i
Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA.
IMR:0100371
IMR:0100372
G-alpha-o
Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA.
PMID:9990023
transducin alpha
G-alpha-t
G-alpha-z
G-alpha-q class
G-alpha-12/13 class
Catalysis role of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
EC:6.2.1.45
IMR:0000327 (obsolete)
Wikipedia:Ubiquitin-activating_enzyme
E1 ubiquitin-activating enzyme
ubiquitin-activating enzyme (E1)
related molecular function GO:0004839
ubiquitin activating enzyme
E1 ubiquitin-activating enzyme
http://enzyme.expasy.org/EC/6.2.1.45
EC:1.14.99.1
prostaglandin endoperoxide synthase
COX
Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein.
CT-10 regulator of kinase
Proto-oncogene C-crk
Crk
Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein.
PMID:10393272
Crk I
Crk-like protein
Crk-L
Crk II
The best characterised member of the SH2/SH3 adaptor protein family is Grb2, the human homologue of the nematode Caenorhabditis elegans protein Sem-5. The structure of Grb2 consists of one SH2 domain flanked by two SH3 domains. Recently, further members of the Grb2 family have been isolated, Grap protein and Gads.
Grb2 family
The best characterised member of the SH2/SH3 adaptor protein family is Grb2, the human homologue of the nematode Caenorhabditis elegans protein Sem-5. The structure of Grb2 consists of one SH2 domain flanked by two SH3 domains. Recently, further members of the Grb2 family have been isolated, Grap protein and Gads.
PMID:10393272
IMR:0010276
ASH protein
Ash
GRB2 adapter protein
Growth factor receptor-bound protein 2
SH2/SH3 adapter GRB2
abundant Src homology protein
growth factor receptor bound protein 2
Grb2
Grb2-related adaptor protein
Grap
The widely expressed Nck is a 47-kDa cytosolic protein exclusively composed of one SH2 and three SH3 domains. Recently, a second member of the Nck family has been isolated (Nck beta/Grb4) which shows 68% amino acid identity to Nck (Nck alpha).
Nck family
The widely expressed Nck is a 47-kDa cytosolic protein exclusively composed of one SH2 and three SH3 domains. Recently, a second member of the Nck family has been isolated (Nck beta/Grb4) which shows 68% amino acid identity to Nck (Nck alpha).
PMID:10393272
IMR:0011207
Cytoplasmic protein NCK1
IRS-4a-P
NCK adaptor protein 1
Nck alpha
SH2/SH3 adaptor protein NCK-alpha
Nck
IMR:0011208
Cytoplasmic protein NCK2
IRS-4b-P
NCK adaptor protein 2
Nck-2
SH2/SH3 adaptor protein NCK-beta
Nck beta/Grb4
src homology and collagen
Shc
SH2 domain-containing leukocyte protein of 76 kD
SLP-76
insulin receptor substrate
IRS
cytokeratin 9
BLNK/SLP-65
Cbl
Growth factor receptor-bound protein 7
Grb7
cytokeratin 10
cytokeratin 12
cytokeratin 13
cytokeratin 14
cytokeratin 15
cytokeratin 16
Smads is a conserved family of signal transducers. Functionally, Smads fall into three subfamilies:R-Smads; Co-Smads; I-Smads. Eight Smad proteins are encoded in vertebrate, four in Drosophila, and three in C. elegans.
IPR:001132
SMAD
Smad
Smads is a conserved family of signal transducers. Functionally, Smads fall into three subfamilies:R-Smads; Co-Smads; I-Smads. Eight Smad proteins are encoded in vertebrate, four in Drosophila, and three in C. elegans.
PMID:11792802
PMID:16322555
PMID:9393997
There are five vertebrate R-Smads, Smad1, Smad2, Smad3, Smad5 and Smad8 and they are phosphorylated in response to different types of TGF-beta ligands. Phosphorylated R-Smads can form complexes with Smad4 and positively or negatively regulate transcription.
The Mad protein in Drosophila is the ortholog of Smad1/5, whereas dSmad2 is the ortholog of Smad2/3. In C. elegans, sma-2 and sma-3 proved to be homologous to Mad of Drosophila.
receptor-activated Smad
receptor-regulated Smad
R-Smad
There are five vertebrate R-Smads, Smad1, Smad2, Smad3, Smad5 and Smad8 and they are phosphorylated in response to different types of TGF-beta ligands. Phosphorylated R-Smads can form complexes with Smad4 and positively or negatively regulate transcription.
The Mad protein in Drosophila is the ortholog of Smad1/5, whereas dSmad2 is the ortholog of Smad2/3. In C. elegans, sma-2 and sma-3 proved to be homologous to Mad of Drosophila.
PMID:16322555
PMID:18061509
PMID:9393997
PMID:9880789
Co-Smad forms hetero-oligomers with R-Smads, which in turn translocate into the nucleus and regulate transcriptional responses.
Only Smad4 has been identified as a common-mediator Smad in vertebrates. A Smad4 homologue has been identified in Drosophila (Medea) and C. elegans (Sma-4).
Smad4
co-mediator Smad
common Smad
common-mediator Smad
common-partner Smad
Co-Smad
Co-Smad forms hetero-oligomers with R-Smads, which in turn translocate into the nucleus and regulate transcriptional responses.
Only Smad4 has been identified as a common-mediator Smad in vertebrates. A Smad4 homologue has been identified in Drosophila (Medea) and C. elegans (Sma-4).
PMID:16322555
PMID:9393997
Smad6 and Smad7 are inhibitory Smads that serve as decoys interfering with Smad-receptor or Smad-Smad interactions. Inhibitory Smads have also been detected in Drosophila (Dad).
inhibitory Smad
I-Smad
Smad6 and Smad7 are inhibitory Smads that serve as decoys interfering with Smad-receptor or Smad-Smad interactions. Inhibitory Smads have also been detected in Drosophila (Dad).
PMID:16322555
PMID:9393997
signal tranducers and activators of transcription
STAT
There are two STAT1 isoforms (STAT1alpha and STAT1beta) produced by alternative splicing of a single mRNA.
signal transducer and activator of transcription 1
STAT1 (mol)
There are two STAT1 isoforms (STAT1alpha and STAT1beta) produced by alternative splicing of a single mRNA.
PMID:1105043
signal transducer and activator of transcription 2
STAT2
signal transducer and activator of transcription 3
STAT3 (mol)
signal transducer and activator of transcription 4
STAT4
signal transducer and activator of transcription 5a
STAT5a
signal transducer and activator of transcription 5b
STAT5b
signal transducer and activator of transcription 6
STAT6
Members of this family include p50, p52, p65, c-Rel, v-Rrel, RelB, and the Drosophila proteins, Dorsal, Dif and Relish. Most of these transcription factors bind as homo- and heterodimers to the consensus a DNA sequence motif termed kappa-B.
IPR:000451
NF-kappa-B
NFkB
Rel/NF-kappaB family
nuclear factor-kappa B
NF-kappaB
Members of this family include p50, p52, p65, c-Rel, v-Rrel, RelB, and the Drosophila proteins, Dorsal, Dif and Relish. Most of these transcription factors bind as homo- and heterodimers to the consensus a DNA sequence motif termed kappa-B.
IPR:000451
NCBI-Human-GeneID:4609
NCBI-Mouse-GeneID:17869
NCBI-Rat-GeneID:24577
c-Myc
Myc (mol)
NCBI-Human-GeneID:4609
http://www.ncbi.nlm.nih.gov/gene/4609
NCBI-Mouse-GeneID:17869
http://www.ncbi.nlm.nih.gov/gene/17869
NCBI-Rat-GeneID:24577
http://www.ncbi.nlm.nih.gov/gene/24577
interferon regulatory factor family
IRF family
interferon regulatory factor-1
IRF-1
interferon regulatory factor-2
IRF-2
IRF-3
IRF-4
IRF-5
IRF-6
IRF-7
ICSBP
IRF9
ISGF3 gamma
p48
IPR:000418
E26 transformation-specific
ets
ets-related gene
ERG
E26 transformation-specific1
ETS1
E26 transformation-specific2
ETS2 (mol)
EGR family
Krox24
NGFI-A
TIS8
Zif268
pAT225
EGR1 (mol)
Krox20
pAT591
EGR2
EGR3
NGFI-C
pAT133
EGR4
c-Myb
Myb
The NFI family is composed of four members in vertebrates (NFI-A, NFI-B, NFI-C and NFI-X).
IPR:000647
CCAAT box-binding transcription factor
CTF
NFI
nuclear factor 1
NF1 (mol)
The NFI family is composed of four members in vertebrates (NFI-A, NFI-B, NFI-C and NFI-X).
PMID:10831836
IPR:004826
musculoaponeurotic fibrosarcoma
Maf family
cytokeratin 17
The AP-1 (activator protein 1) transcription factor is a dimeric complex that comprises members of the JUN, FOS, ATF (activating transcription factor) and MAF (musculoaponeurotic fibrosarcoma) protein families. The AP-1 complex can therefore form many different combinations of heterodimers and homodimers, and this combination determines the genes that are regulated by AP-1.
AP-1
The AP-1 (activator protein 1) transcription factor is a dimeric complex that comprises members of the JUN, FOS, ATF (activating transcription factor) and MAF (musculoaponeurotic fibrosarcoma) protein families. The AP-1 complex can therefore form many different combinations of heterodimers and homodimers, and this combination determines the genes that are regulated by AP-1.
PMID:14668816
IPR:000837
FOS family
IPR:002112
JUN (mol)
BCL-6 belongs to a subset of transcription factors which all have a similar structure composed of an amino-terminal 'POZ' domain and several zinc finger modules at the carboxy-terminus. BCL-6 is highly conserved among vertebrate species. BCL-6 homologues have been identified from human, mouse, frog, and chicken species.
BCL-6
BCL-6 belongs to a subset of transcription factors which all have a similar structure composed of an amino-terminal 'POZ' domain and several zinc finger modules at the carboxy-terminus. BCL-6 is highly conserved among vertebrate species. BCL-6 homologues have been identified from human, mouse, frog, and chicken species.
PMID:11796228
T-cell factor/lymphoid-enhancer factor
TCF/LEF-1 family
NFAT proteins are a family of transcription factors (NFATC1~C4) whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase.
Nuclear factor of activated T-cells
NF-AT
NFAT proteins are a family of transcription factors (NFATC1~C4) whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase.
PMID:11877454
PMID:11983154
CCAAT/enhancer binding protein
C/EBP
p300/CBP
RGS proteins act as negative regulators of G protein dependent signaling, at least in part, because they stimulate hydrolysis of the GTP bound to activated G alpha subunits.
GO:0016299
regulator of G protein signaling
RGS
RGS proteins act as negative regulators of G protein dependent signaling, at least in part, because they stimulate hydrolysis of the GTP bound to activated G alpha subunits.
PMID:9064301
Axin/conductin
Axin
GO:0005085
guanine nucleotide exchange factor
GEF
Vav
Drosophila Son of Sevenless (SOS) is homologous to the yeast exchange factor for Ras, CDC25. Mammalian cells contain two closely related homologs of Drosophila SOS: SOS1 and SOS2. Biochemical studies have established that SOS indeed functions as a guanine nucleotide exchange factor for Ras.
son of sevenless
Sos
Drosophila Son of Sevenless (SOS) is homologous to the yeast exchange factor for Ras, CDC25. Mammalian cells contain two closely related homologs of Drosophila SOS: SOS1 and SOS2. Biochemical studies have established that SOS indeed functions as a guanine nucleotide exchange factor for Ras.
UniProt:12177507
Crk SH3 domein binding GEF
Guanine nucleotide-releasing factor 2
C3G
Dbl
cytohesin
GO:0008321
Ral guanine nucleotide exchange factor
RalGEF
RasGRF
GO:0005096
GTPase activating protein
GAP family
GO:0005099
Ras GTPase-activating protein
Ras GAP
GO:0005092
GDP-dissociation inhibitor
guanine nucleotide dissociation inhibitor
GDI
GO:0004861
cyclin-dependent kinase inhibitor
cyclin-dependent protein kinase inhibitor
CKI
Cip/Kip family
INK4 family
The Bcl-2 family consists of about 20 homologues of important pro- and anti-apoptotic regulators of programmed cell death.
B cell lymphoma/leukemia-2 family
Bcl-2 family
The Bcl-2 family consists of about 20 homologues of important pro- and anti-apoptotic regulators of programmed cell death.
PMID:14634621
PMID:14996506
BAK
BAX (mol)
inhibitor of apoptosis-family
IAP-family
The term 14-3-3 denotes a large family of ~30 kDa acidic proteins that exist primarily as homo- and heterodimers within all eukaryotic cells. Their unusual name refers to their elution position on DEAE-cellulose chromatography and gel electrophoresis during a systematic attempt at classifying bovine brain proteins. In humans, there are seven distinct 14-3-3 genes denoted beta, gamma, epsilon, eta, sigma, tau (theta) and zeta (as well as a number of potential pseudogenes), while yeast and plants contain between 2 and 15 genes.
IPR:000308
http://purl.obolibrary.org/obo/PR_000003237
14-3-3
The term 14-3-3 denotes a large family of ~30 kDa acidic proteins that exist primarily as homo- and heterodimers within all eukaryotic cells. Their unusual name refers to their elution position on DEAE-cellulose chromatography and gel electrophoresis during a systematic attempt at classifying bovine brain proteins. In humans, there are seven distinct 14-3-3 genes denoted beta, gamma, epsilon, eta, sigma, tau (theta) and zeta (as well as a number of potential pseudogenes), while yeast and plants contain between 2 and 15 genes.
PMID:11911880
cytokeratin 18
cytokeratin 19
CIS
Cytokine-inducible SH2 protein
SSI
STAT induced STAT inhibitor
Suppressor of cytokine signaling
SOCS
TNF receptor associated factor family
TRAF family
I-kappaB family
IkB
inhibitor of NF-kappaB
I-kappaB
cytokeratin 20
cytokeratin 23
cytokeratin 6
cytokeratin 21
NF-H
NF-L
NF-M
alpha-actinin 1
alpha-actinin 2
alpha-actinin 3
alpha-actinin 4
cytoplasmic actin
beta-actin
cardiac muscle actin
alpha-cardiac actin
gamma-actin
skeletal muscle alpha-actin
alpha-actin 1
alpha-actin
gamma-actin 2
gamma-enteric actin
smooth muscle (enteric type) gamma-actin
smooth muscle gamma-actin
alpha-actin 3
smooth muscle alpha-actin (aortic type)
alpha-actin 2
caveolin
arrestin
Aquaporin
connexin
myelin protein
GO:0005581
collagen
Types I, II and III collagens constitute the classical fibrillar collagens and account for 80-90% of all the collagen in the body. Types V and XI collagens are also classified as fibrillar collagens on the basis of thier homology with types I-III collagens.
GO:0005583
fibrillar forming collagen
fibrillar collagen
Types I, II and III collagens constitute the classical fibrillar collagens and account for 80-90% of all the collagen in the body. Types V and XI collagens are also classified as fibrillar collagens on the basis of thier homology with types I-III collagens.
ISBN:0120689111
associate with the surface of fibrils and modify their interactive properties.
GO:0005593
FACIT collagen
fibril associated collagens with interrupted triple helix
fibril-associated collagen
associate with the surface of fibrils and modify their interactive properties.
ISBN:0120689111
fibronectin
elastin
GO:0005587
type IV collagen
Proteoglycans are a diverse family of molecules characterized by a core protein to which is attached one or more glycosaminoglycan (GAG) side-chains.
proteoglycan
Proteoglycans are a diverse family of molecules characterized by a core protein to which is attached one or more glycosaminoglycan (GAG) side-chains.
ISBN:0120689111
laminin family
kalinin
disabled
The MyD118/CR6/Gadd45 gene family (also termed Gadd45b, Gadd45g, Gadd45a) encodes for small (18 kd), evolutionary conserved proteins that are highly homologous to each other (55 57% overall identity at the amino acid level), are highly acidic (pI=4.0 4.2), and are primarily localized within the cell nucleus. MyD118/CR6/GADD45 serve similar, but not identical, functions along different apoptotic and growth inhibitory pathways. They interact with cell cycle proteins.
growth arrest and DNA damage inducible 45
GADD45
The MyD118/CR6/Gadd45 gene family (also termed Gadd45b, Gadd45g, Gadd45a) encodes for small (18 kd), evolutionary conserved proteins that are highly homologous to each other (55 57% overall identity at the amino acid level), are highly acidic (pI=4.0 4.2), and are primarily localized within the cell nucleus. MyD118/CR6/GADD45 serve similar, but not identical, functions along different apoptotic and growth inhibitory pathways. They interact with cell cycle proteins.
PMID:12032777
presenilin
Placental-cadherin
cadherin-3
P-cadherin
Kidney-cadherin
cadherin-6
K-cadherin
IFN alpha-1
IFN alpha-2
IFN alpha-4
IFN alpha-5
IFN alpha-6
IFN alpha-7
IFN alpha-8
IFN alpha-9
IFN alpha-10
IFN alpha-14
IFN alpha-16
IFN alpha-17
IFN alpha-21
GO:0005136
interleukin-4
IL-4 (mol)
GO:0005139
interleukin-7
IL-7
interleukin-8
IL-8
GO:0005140
interleukin-9
IL-9
GO:0005141
interleukin-10
IL-10 (mol)
interleukin-12
IL-12
IL-1RI : IL-1R AcP
IL-1RII : IL-1R AcP
interleukin-13
IL-13
High molecular weight B-cell growth factor
interleukin-14
IL-14
interleukin-15
IL-15
LCF
interleukin-16
lymphocyte chemoattractant factor
IL-16
CTLA-8
cytotoxic T lymphocyte-associated antigen 8
interleukin-17
IL-17
GO:0030368
interleukin-17 receptor
IL-17 receptor
interleukin-18
IL-18
GO:0016517
interleukin-12 receptor
IL-12 receptor
GO:0004918
interleukin-8 receptor
IL-8 receptor
interleukin-8 receptor A
IL-8RA
interleukin-8 receptor B
IL-8RB
GO:0004920
interleukin-10 receptor
IL-10 receptor
GO:0004921
IL-11 receptor
NRG-1
neuregulin-1
NRG-2
neuregulin-2
NRG-3
neuregulin-3
NRG-4
neuregulin-4
intercellular adhesion molecule 1
ICAM-1
intercellular adhesion molecule 2
ICAM-2
intercellular adhesion molecule 3
ICAM-3
intercellular adhesion molecule 4
ICAM-4
intercellular adhesion molecule 5
ICAM-5
Integrin alpha-1
Integrin alpha-2
Integrin alpha-3
Integrin alpha-4
Integrin alpha-5
Integrin alpha-6
Integrin alpha-7
Integrin alpha-8
Integrin alpha-9
Integrin alpha-10
Integrin alpha-11
Integrin alpha-IIb
Integrin alpha-D
Integrin alpha-E
Integrin alpha-L
Integrin alpha-M
Integrin alpha-V
Integrin alpha-X
Integrin beta-1
Integrin beta-2
Integrin beta-3
Integrin beta-4
Integrin beta-5
Integrin beta-6
Integrin beta-7
Integrin beta-8
CD44 (mol)
LFA-1
PAK2
PAK3
PAK4
PAK5
PAK6
PAK5
PAK7
A-Raf
B-Raf
IMR:0000678
type I alpha cGMP-dependent protein kinase
type I beta cGMP-dependent protein kinase
cGMP-dependent protein kinase I
type II cGMP-dependent protein kinase
cGMP-dependent protein kinase II
Plk1
Plk3
SAPK-1
p54 gamma SAPK
JNK1
p54 alpha SAPK
JNK2
p54 beta SAPK
JNK3
CRK1
CSBP1
CSBP2
MPK2
Mxi2
RK
RK/p38
SAPK-2
SAPK2a
p38 MAPK
p38/HOG1
p40
p38alpha
SAPK2b
p38-2
p38beta
ERK6
SAPK-3
p38gamma
SAPK-4
p38delta
IMR:0011341
NCBI-Human-GeneID:3265
NCBI-Mouse-GeneID:15461
NCBI-Rat-GeneID:293621
H-Ras
HRAS
Ha-ras
Transforming protein p21/H-Ras-1
c-H-ras
HRAS (mol)
NCBI-Human-GeneID:3265
https://www.ncbi.nlm.nih.gov/gene/3265
NCBI-Mouse-GeneID:15461
https://www.ncbi.nlm.nih.gov/gene/15461
NCBI-Rat-GeneID:293621
https://www.ncbi.nlm.nih.gov/gene/293621
IMR:0011343
NCBI-Human-GeneID:4893
NCBI-Mouse-GeneID:18176
NCBI-Rat-GeneID:24605
N-Ras
Transforming protein N-Ras
NRAS (mol)
NCBI-Human-GeneID:4893
https://www.ncbi.nlm.nih.gov/gene/4893
NCBI-Mouse-GeneID:18176
https://www.ncbi.nlm.nih.gov/gene/18176
NCBI-Rat-GeneID:24605
https://www.ncbi.nlm.nih.gov/gene/24605
IMR:0011342
K-Ras 2A
K-Ras4A
KRAS2
Ki-Ras
Transforming protein p21A
c-K-ras
K-Ras2A
K-Ras4B
K-Ras2B
Cdc42
p50:RelA
GO:0008384
I-kappaB kinase family
IKK family
phospholipase C beta 1
PLCbeta1
phospholipase C beta 2
PLCbeta2
phospholipase C beta 3
PLCbeta3
phospholipase C beta 4
PLCbeta4
phospholipase D1
PLD1
phospholipase D2
PLD2
phospholipase C gamma 1
PLC gamma1
phospholipase C gamma 2
PLC gamma2
prostaglandin endoperoxide synthase 2
COX-1
NCBI-Human-GeneID:5743
NCBI-Mouse-GeneID:19225
NCBI-Rat-GeneID:29527
cyclooxygenase 2
prostaglandin endoperoxide synthase 2
COX-2 (mol)
NCBI-Human-GeneID:5743
https://www.ncbi.nlm.nih.gov/gene/5743
NCBI-Mouse-GeneID:19225
https://www.ncbi.nlm.nih.gov/gene/19225
NCBI-Rat-GeneID:29527
https://www.ncbi.nlm.nih.gov/gene/29527
IMR:0010277
GRB10 adaptor protein
Growth factor receptor-bound protein 10
Insulin receptor binding protein GRB-IR
Grb10
Grb14
IMR:0010596
IMR:0011555
ShcA
ShcB
ShcC
Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads is a unique member of the Grb2 adaptor family.
Grb2-related adaptor downstream of Shc
Gads
Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads is a unique member of the Grb2 adaptor family.
PMID:11607830
Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. The Crk-II protein contains an amino-terminal SH2 domain followed by two SH3 domains. The Crk-I protein does not contain the second SH3 domain. The 36-kDa Crk-L protein is similar to CrkII, but is encoded by a separate gene.
Crk family
Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. The Crk-II protein contains an amino-terminal SH2 domain followed by two SH3 domains. The Crk-I protein does not contain the second SH3 domain. The 36-kDa Crk-L protein is similar to CrkII, but is encoded by a separate gene.
PMID:10393272
RyR
ryanodine receptor
GADD45 alpha
MyD118
GADD45 beta
CR6
GADD45 gamma
disabled-1
DOC-2
disabled-2
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
B7.1
CD80
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
PMID:14647476
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
B7.2
CD86
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
PMID:14647476
c-FOS
FOSB
FRA-1
FRA-2
AP-1
c-JUN
JUNB (mol)
JUND (mol)
c-Maf
MafF
MafG
MafK
MafB
activating transcription factor
ATF
activating transcription factor 1
ATF-1 (mol)
activating transcription factor 2
ATF-2 (mol)
activating transcription factor 5
ATF-5 (mol)
activating transcription factor 6 alpha
ATF-6 alpha
activating transcription factor 6 beta
ATF-6 beta
ATF-a
activating transcription factor 7
ATF-7 (mol)
CCAAT/enhancer binding protein alpha
C/EBP alpha
CCAAT/enhancer binding protein beta
C/EBP beta
CCAAT/enhancer binding protein delta
C/EBP delta
CCAAT/enhancer binding protein gamma
C/EBP gamma
CCAAT/enhancer binding protein epsilon
C/EBP epsilon
NF-ATc1
NF-ATc2
NF-ATc3
NF-ATc4
IMR:0010101
14-3-3 protein beta/alpha
KCIP-1
Protein 1054
Protein kinase C inhibitor protein-1
14-3-3 beta
14-3-3 gamma
14-3-3 epsilon
14-3-3 eta
14-3-3 sigma
14-3-3 tau/theta
14-3-3 zeta
A-Myb
B-Myb
Myb family
IMR:0010365
CCAAT-box binding transcription factor
CTF
NF-I/A
NF1-A
NFI-A
Nuclear factor 1 A-type
Nuclear factor 1/A
TGGCA-binding protein
NF1-A
IMR:0010366
CCAAT-box binding transcription factor
CTF
NF-I/B
NF1-B
NFI-B
Nuclear factor 1 B-type
Nuclear factor 1/B
TGGCA-binding protein
NF1-B
IMR:0010367
CCAAT-box binding transcription factor
CTF
NF-I/C
NF1-C
NFI-C
Nuclear factor 1 C-type
Nuclear factor 1/C
TGGCA-binding protein
NF1-C
IMR:0010368
CCAAT-box binding transcription factor
CTF
NF-I/X
NF1-X
NFI-X
Nuclear factor 1 X-type
Nuclear factor 1/X
TGGCA-binding protein
NF1-X
NF-kappaB2
NFKB2
p100
p52
CHEBI:24020
fat-soluble vitamin
TFIIA
TFIID
TFIIE
TFIIF
TFIIH
pol II general transcription factor
transcription factor for RNA polymerase II
TFII
IL-1 receptor-associated kinase 1
Interleukin-1 receptor-associated kinase 1
IRAK-1
IL-1 receptor-associated kinase 2
Interleukin-1 receptor-associated kinase-2
IRAK-2
IL-1 receptor-associated kinase 4
Interleukin-1 receptor-associated kinase-4
IRAK-4
Toll-interacting protein
Tollip
40S ribosomal protein
60S ribosomal protein
heterotrimer of alpha, beta, gamma subunits. binds the initiator Met-tRNA to the 40S ribosomal subunit. GTP binding to eIF2 is necessary for formation of a stable eIF2:GTP:Met-tRNA ternary complex (TC). Following TC binding to the ribosome triggers GTP hydrolysis by eIF2.
eukaryotic initiation factor 2
eIF2
heterotrimer of alpha, beta, gamma subunits. binds the initiator Met-tRNA to the 40S ribosomal subunit. GTP binding to eIF2 is necessary for formation of a stable eIF2:GTP:Met-tRNA ternary complex (TC). Following TC binding to the ribosome triggers GTP hydrolysis by eIF2.
PMID:12581660
PMID:14635255
heteropentamer of alpha, beta, gamma, delta, epsilon subunits. guanine nucleotide exchange factor (GEF) activity of eIF2B is necessary to recycle eIF2:GTP to eIF2:GTP.
eukaryotic initiation factor 2B
eIF2B
heteropentamer of alpha, beta, gamma, delta, epsilon subunits. guanine nucleotide exchange factor (GEF) activity of eIF2B is necessary to recycle eIF2:GTP to eIF2:GTP.
PMID:12581660
PMID:14635255
consists of a core of five non-identical subunits (eIF3a, eIF3b, eIF3c, eIF3i and eIF3g in yeast) and up to six additional subunits in mammals (eIF3d, eIF3e, eIF3f, eIF3h, eIFj and eIF3k). binding to and stabilization of ternary complex, binding to the 40S ribosome, facilitating the binding of mRNA to the 40S ribosome, and promoting dissociation of 40S and 60S ribosomal subunits
eukaryotic initiation factor 3
eIF3
consists of a core of five non-identical subunits (eIF3a, eIF3b, eIF3c, eIF3i and eIF3g in yeast) and up to six additional subunits in mammals (eIF3d, eIF3e, eIF3f, eIF3h, eIFj and eIF3k). binding to and stabilization of ternary complex, binding to the 40S ribosome, facilitating the binding of mRNA to the 40S ribosome, and promoting dissociation of 40S and 60S ribosomal subunits
PMID:11426420
PMID:14635255
eIF4A is a DEADbox helicase that can unwind RNA secondary structure in the cap-proximal region of the mRNA.
eukaryotic initiation factor 4A
eIF4A
eIF4A is a DEADbox helicase that can unwind RNA secondary structure in the cap-proximal region of the mRNA.
PMID:14635255
eIF1 (mol)
eIF4F is a heterotrimeric complex that binds to the cap structure at the 50 end of the mRNA. It is composed of eIF4G and the cap-binding protein eIF4E and the ATPdependent RNA helicase eIF4A.
eIF4F
eIF4F is a heterotrimeric complex that binds to the cap structure at the 50 end of the mRNA. It is composed of eIF4G and the cap-binding protein eIF4E and the ATPdependent RNA helicase eIF4A.
PMID:14635255
Mammalian cells contain two isoforms of eIF4G (I&II). eIF4G is a subunit of the heterotrimeric eIF4F complex that binds to the cap structure at the 50 end of the mRNA.
eukaryotic translation initiation factor 4G
eIF4G
Mammalian cells contain two isoforms of eIF4G (I&II). eIF4G is a subunit of the heterotrimeric eIF4F complex that binds to the cap structure at the 50 end of the mRNA.
PMID:14635255
Eukaryotic translation initiation factor 4 gamma 3
eIF-4-gamma 3
eIF-4-gamma II
eIF-4G 3
eIF4G 3
eIF4GII
eIF4F subunit
eIF2 subunit
eIF2B subunit
eIF3 subunit
LDL receptor-related protein 3
low density lipoprotein receptor-related protein 3
LRP3
LDL receptor-related protein 4
low density lipoprotein receptor-related protein 4
LRP4
LDL receptor-related protein 5
LRP7
low density lipoprotein receptor-related protein 5
LRP5
chemical hormone
LDL receptor-related protein 6
low density lipoprotein receptor-related protein 6
LRP6
LDL receptor-related protein 8
low density lipoprotein receptor-related protein 8
LRP8 (mol)
GO:0005041
LDLR family
low density lipoprotein receptor family
low-density lipoprotein receptor family
LDL receptor family
LDL receptor-related protein 1B
LRP1B
LDL receptor-related protein 10
LRP10
LDL receptor-related protein 11
LRP11
LDL receptor-related protein 12
LRP12
low density lipoprotein receptor
low-density lipoprotein receptor
LDL receptor
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
CGB-PDE
cGMP-binding cGMP-specific phosphodiesterase
cGMP-specific 3',5'-cyclic phosphodiesterase
High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
GMP-PDE gamma
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit
Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit
GMP-PDE beta
Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit
Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit
GMP-PDE delta
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase delta-subunit
GMP-PDE gamma
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit
group III secretory phospholipase A2
group V phospholipase A2
group VI phospholipase A2
group IIA phospholipase A2
group IID secretory phospholipase A2
group IIE secretory phospholipase A2
group IIF secretory phospholipase A2
group X secretory phospholipase A2
group XIIA secretory phospholipase A2
group XIIB secretory phospholipase A2-like protein
group IVA phospholipase A2
group IVC phospholipase A2
group IIC secretory phospholipase A2
EC:3.1.2.-
thiolester hydrolases
EC:3.1.2.15
ubiquitin carboxy-terminal esterase
ubiquitin carboxy-terminal hydrolase
ubiquitin thiolesterase
KPNA1
NPI-1
importin alpha S1
importin alpha5
karyopherin alpha1
importin alpha1
KPNA2
importin alpha P1
importin alpha1
karyopherin alpha2
importin alpha2
KPNA3
importin alpha Q2
importin alpha4
karyopherin alpha3
importin alpha3
KPNA4
Qip1
importin alpha Q1
importin alpha3
karyopherin alpha4
importin alpha4
KPNA5
karyopherin alpha5
importin alpha6
KPNA6
importin alpha S2
karyopherin alpha6
importin alpha7
exportin 1
CRM1
Members of importin beta family (importins/exportins, karyopherins) have been classified as importins or exportins on the basis of the direction they carry their cargo.
Kap
inportin beta family
inportin beta-like family
inportin beta-like protein
inportin beta-like receptor
karyopherin
karyopherin beta family
importin/exportin
Members of importin beta family (importins/exportins, karyopherins) have been classified as importins or exportins on the basis of the direction they carry their cargo.
PMID:11423015
PMID:11729264
PMID:12600309
PMID:15450977
FLI1
ETV5
ERM
Elk-1
Elk-4
Sap-1
importin beta2
karyopherin beta2
transportin 1
transportin SR
exportin 4
RanBP16
exportin 7
exportin-t
RanBP5
karyopherin beta3
importin 5
RanBP7
importin 7
importin 11
Elk-3
Sap-2
Net
importin 13
PU.1
IQGAP1
karyopherin beta2b
transportin 2
RanBP17
RanBP6
RanBP8
importin 8
importin 4
importin 9
exportin 5
IQGAP2
RASAL1
RASA4
GO:0005598
short chain collagen
GO:0005599
type X collagen
GO:0005591
type VIII collagen
basement membrane collagen
HSPG
heparan sulfate proteoglycan
chondroitin sulfate proteoglycan
chondroitin sulfate proteoglycan
chondroitin/dermatan sulfate proteoglycan
chondroitin/dermatan sulfate proteoglycan
keratan sulfate proteoglycan
lumican
neurocan
basement membrane heparan sulfate proteoglycan
perlecan
PG-M
versican
aggrecan
agrin
brevican
decorin
keratocan
GPI-anchored membrane heparan sulfate proteoglycan
glypican (mol)
glypican-1
HSPG-M13
cerebroglycan
K-glypican
biglycan
NG2
PKC alpha
PKC beta
PKC gamma
PKC delta
PKC epsilon
PKC-L
PKC eta
PKC zeta
PKC lambda/iota
Apo-2 ligand
Apo2L
TNF-related apoptosis inducing ligand
TNFSF10
TRAIL
DR4
TNF-related apoptosis-inducing ligand receptor 1
TRAIL receptor-1
TRAIL-R1
death receptor 4
TRAIL-R1
DR5
KILLER
TRAIL receptor-2
TRAIL-R2
TRICK2
death receptor 5
TRAIL-R2
Apaf-1
Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.
MeSH:D003574
MeSH:D045304
Cyt c
cytochrome c
Bmf
DLC8b
dynein light chain 2
DLC2
Noxa
bbc3
Puma
DLC8a
PIN
dynein light chain 1
protein inhibitor of neuronal nitric oxide synthase
DLC1
Axin
Axin1
Axil
Axin-like protein
conductin
Axin2
CHEBI:23447
cyclic nucleotide
IMR:0200191
GDP
Gli1
Gli2
Gli3
Ci/Gli
phosphoinositol
inositol phosphate
CREB-binding protein
CBP
p300
Gab proteins contain a pleckstrin homology (PH) domain and binding sites for SH2 and SH3 domains. Gab family include mammalian Gab1, Gab2, Gab3, Drosophila Dos, and C. elegans Soc1.
Grb2-associated binder
Gab
Gab proteins contain a pleckstrin homology (PH) domain and binding sites for SH2 and SH3 domains. Gab family include mammalian Gab1, Gab2, Gab3, Drosophila Dos, and C. elegans Soc1.
PMID:14662016
Grb2-associated binder 1
Gab1 (mol)
Grb2-associated binder 2
Gab2
Grb2-associated binder 3
Gab3
ISGF3 is a heterotrimer of STAT1, STAT2 and p48/ISGF3gamma/IRF9.
IFN-stimulated gene factor 3
interferon-stimulated gene factor 3
ISGF3
ISGF3 is a heterotrimer of STAT1, STAT2 and p48/ISGF3gamma/IRF9.
PMID:11050435
PMID:12040185
STAT1 dimers form the IFNgamma-activated factor (GAF).
IFNgamma-activated factor
gamma-activated factor
GAF
STAT1 dimers form the IFNgamma-activated factor (GAF).
PMID:11050435
PMID:12040185
BMP2
Bone morphogenetic protein 2
BMP-2
BMP3
Bone morphogenetic protein 3
BMP-3
BMP3b
Bone morphogenetic protein 3b
GDF-10
GDF10
BMP-3b
BMP4
Bone morphogenetic protein 4
BMP-4
BMP5
Bone morphogenetic protein 5
BMP-5
BMP6
Bone morphogenetic protein 6
Vgr-1
BMP-6
BMP7
Bone morphogenetic protein 7
OP-1
BMP-7
BMP8a
Bone morphogenetic protein 8a
OP-2
BMP-8a
BMP8b
Bone morphogenetic protein 8b
OP-3
BMP-8b
BMP10
Bone morphogenetic protein 10
BMP-10
BMP15
Bone morphogenetic protein 15
GDF-9b
GDF9b
Growth/differentiation factor 9B
BMP-15
BMP-11
BMP11
Bone morphogenetic protein 11
GDF11
Growth/differentiation factor 11
GDF-11
BMP-9
BMP9
Bone morphogenetic protein 9
Growth/differentiation factor-2
GDF-2
NCBI-Human-GeneID:7099
NCBI-Mouse-GeneID:21898
NCBI-Rat-GeneID:29260
Toll-like receptor 4
TLR4 (mol)
NCBI-Human-GeneID:7099
https://www.ncbi.nlm.nih.gov/gene/7099
NCBI-Mouse-GeneID:21898
https://www.ncbi.nlm.nih.gov/gene/21898
NCBI-Rat-GeneID:29260
https://www.ncbi.nlm.nih.gov/gene/29260
Toll-like receptor 1
TLR1
Toll-like receptor 2
TLR2
Toll-like receptor 5
TLR5
Toll-like receptor 3
TLR3
Toll-like receptor 6
TLR6
Toll-like receptor 7
TLR7
Toll-like receptor 8
TLR8
NCBI-Human-GeneID:54106
NCBI-Mouse-GeneID:81897
NCBI-Rat-GeneID:338457
Toll-like receptor 9
TLR9 (mol)
NCBI-Human-GeneID:54106
https://www.ncbi.nlm.nih.gov/gene/54106
NCBI-Mouse-GeneID:81897
https://www.ncbi.nlm.nih.gov/gene/81897
NCBI-Rat-GeneID:338457
https://www.ncbi.nlm.nih.gov/gene/338457
DOCK1
DOCK180
Superfamily members of DOCK180 possess the DHR-2 domain and bind to and exchange GDP for GTP on either Rac or Cdc42.
DOCK
Superfamily members of DOCK180 possess the DHR-2 domain and bind to and exchange GDP for GTP on either Rac or Cdc42.
PMID:12432077
DOCK2
DOCK3
DOCK4
DOCK5
DOCK6
DOCK7
DOCK8
DOCK9
DOCK10
Rac1
Rac2
Rac3
Rap1
Rap1A
Rap1B
Rap2
Rap2A
Rap2B
Rap2C
RalA
RalB
R-Ras1
R-Ras2
R-Ras3
M-Ras
Rab1A
Rab1B
Rab2A
Rab2B
Rab3A
Rab3B
Rab3C
Rab3D
Rab4A
Rab4B
Rab5A
Rab5B
Rab5C
Rab6A
Rab6B
Rab6C
Rab7
Rab7L
Rab8A
Rab8B
Rab9A
Rab9B
Rab10
Rab11A
Rab11B
Rab12
Rab13 (mol)
Rab14
Rab15
Rab17
Rab18
Rab19
Rab20
Rab21
Rab22A
Rab23
Rab24
Rab25
Rab26
Rab27A
Rab27B
Rab28
Rab30
Rab31
Rab32
Rab33A
Rab33B (mol)
Rab34
Rab35
Rab36
Rab37
Rab38
Rab39A
Rab39B
Rab40A
Rab40B
Rab40C
RABL2A
RABL2B
Cav-1
caveolin-1
Cav-2
caveolin-2
Cav-3
caveolin-3
CHEBI:27305
vitamin
RGS1
RGS2
RGS3
RGS4
RGS5
RGS6
RGS7
RGS8
RGS9
RGS10
RGS11
RGS12
RGS13
RGS14
RGS16
RGS17
RGS18
RGS19
RGS20
MAPKAPK2 and MAPKAPK3 can be activated by p38 and activated MAPKAPK2/3 can phosphorylate small heat shock protein 27 (HSP27).
MAP kinase-activated protein kinase 2/3
MAPK-activated protein kinase 2/3
MAPKAPK2/3
MAPKAPK2 and MAPKAPK3 can be activated by p38 and activated MAPKAPK2/3 can phosphorylate small heat shock protein 27 (HSP27).
PMID:9628874
MAP kinase signal-integrating kinase 1
MAP kinase-interacting kinase 1
MNK1
MAP kinase signal-integrating kinase 2
MAP kinase-interacting kinase 2
MNK2
HSP27
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
CHEBI:32952
MeSH:D000588
amine
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH:D000588
CHEBI:33567
catecholamine
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
glycoside
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
MeSH:D006027
Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, is not present in eukaryotes, and is an excellent target for the innate immune system.
MeSH:D010457
PGN
murein
peptidoglycan
Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, is not present in eukaryotes, and is an excellent target for the innate immune system.
PMID:16263004
Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.
vinculin
Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.
UniProt:P18206
component of fungal cell walls.
MeSH:C033363
(1 --> 3)-beta-D-glucan
(1,3)-beta-D-glucan
(1-->3)-beta-D-glucan
(1->3)-beta-D-glucan
beta-1,3-D-glucan
beta-1,3-glucan
component of fungal cell walls.
MeSH:C033363
ribosomal S6 protein kinase
S6K
70 kDa ribosomal S6 kinase
p70S6K
90 kDa ribosomal S6 kinase1
p90RSK1
RSK1
90 kDa ribosomal S6 kinase2
p90RSK2
RSK2
90 kDa ribosomal S6 kinase3
p90RSK3
RSK3
a disintegrin and metalloproteinase
ADAM family
ADAM17
TNF-alpha converting enzyme
a disintegrin and metalloproteinase 17
TACE
a disintegrin and metalloproteinase 10
ADAM10
mastermind family
MAM family
MAML1
RhoA
GO:0005089
Rho guanine nucleotide exchange factor
RhoGEF
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1 and Rap2, which are directly regulated by cAMP.
exchange protein directly activated by cAMP
Epac
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1 and Rap2, which are directly regulated by cAMP.
PMID:9856955
Epac
cAMP-GEFI
Epac1
cAMP-GEFII
Epac2
GO:0017034
Rap guanine nucleotide exchange factor
RapGEF
NDK5
NDK6
NDK7
fibroblast growth factor receptor 1
FGFR1
fibroblast growth factor receptor 2
FGFR2
fibroblast growth factor receptor 3
FGFR3
fibroblast growth factor receptor 4
FGFR4
Sos1
Sos2
Antibody molecule (immunoglobulin) consists of four polypeptides chains, two identical light (L) chains and two identical heavy (H) chains.
In mammals, there are five classes of antibodies, IgA, IgD, IgE, IgG, and IgM.
GO:0003823
Ig
antibody
immunoglobulin
Antibody molecule (immunoglobulin) consists of four polypeptides chains, two identical light (L) chains and two identical heavy (H) chains.
In mammals, there are five classes of antibodies, IgA, IgD, IgE, IgG, and IgM.
ISBN:0815340729
immunoglobulin A
IgA
immunoglobulin E
IgE
immunoglobulin G
IgG
CHEBI:27584
11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al
Aldosterone
aldosterone
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
CHEBI:22879
MeSH:D001679
biogenic amine
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
MeSH:D001679
methionyl-lysyl-bradykinin
beta-LPH
beta lipotropin
gamma-LPH
gamma lipotropin
T-cell receptor gamma
TCR gamma
T-cell receptor delta
TCR delta
UBE2N
Uev1A
The MHC class Ib family members include HLA-E, HLA-F, HLA-G and HFE (HLA-H) in humans and gene products from the H2-M, H2-Q and H2-T regions in mice.
MHC class Ib molecule
nonclassical MHC class I molecule
The MHC class Ib family members include HLA-E, HLA-F, HLA-G and HFE (HLA-H) in humans and gene products from the H2-M, H2-Q and H2-T regions in mice.
PMID:10607669
PMID:16860610
MHC class II-like proteins are produced from the class II region of the MHC, HLA-DM (DM) and HLA-DO (DO) (called H2-M, or H2-DM and H2-O in the mouse).
nonclassical MHC class II molecule
MHC class II-like proteins are produced from the class II region of the MHC, HLA-DM (DM) and HLA-DO (DO) (called H2-M, or H2-DM and H2-O in the mouse).
PMID:10837054
Ins(1,4,5)P3 3-kinases (IP3-3K) are the enzymes responsible for the ATP-dependent conversion of Ins(1,4,5)P3 to Ins(1,3,4,5)P4. Three mammalian isoforms of this enzyme have so far been isolated and designated the A, B and C isoforms.
GO:0008440
IP(3) 3-kinase
IP(3)K
IP3 3-kinase
IP3-3K
IP3K
Ins(1,4,5)P3 3-kinase
inositol 1,4,5-trisphosphate 3-kinase
Ins(1,4,5)P3 3-kinases (IP3-3K) are the enzymes responsible for the ATP-dependent conversion of Ins(1,4,5)P3 to Ins(1,3,4,5)P4. Three mammalian isoforms of this enzyme have so far been isolated and designated the A, B and C isoforms.
PMID:15093605
PMID:15740635
IP3K-A
inositol 1,4,5-trisphosphate 3-kinase A
IP3K-B
inositol 1,4,5-trisphosphate 3-kinase B
IP3K-C
inositol 1,4,5-trisphosphate 3-kinase C
CARMEN
CIPER
CLAP
c-E10
mE10
BCL10
IGFBPs are a family of secreted proteins that bind IGF with high affinities that are equal to or greater than those of the IGF-IR. Six distinct IGFBPs, designated as IGFBP-1 to -6, have been isolated and characterized from human and a variety of vertebrate species.
IGF-binding protein
insulin-like growth factor-binding protein
IGFBP
IGFBPs are a family of secreted proteins that bind IGF with high affinities that are equal to or greater than those of the IGF-IR. Six distinct IGFBPs, designated as IGFBP-1 to -6, have been isolated and characterized from human and a variety of vertebrate species.
PMID:12466191
PMID:15862547
PMID:15935690
IGFBP-2
IGFBP-3
IGFBP-4
IGFBP-5
IGFBP-6
GO:0045519
interleukin-23
IL-23
GO:0042020
interleukin-23 receptor
IL-23 receptor
GO:0045523
interleukin-27
IL-27
TOR
TSC2
AMPK beta subunit
AMPK gamma subunit
S6K1
S6K2
FOXO proteins are conserved from worm to human. To date, only one FOXO species has been identified in invertebrates (called dauer formation-16 in Caenorhabditis elegans and dFOXO in Drosophila). In mammals, four subfamily members have been identified: FOXO1 (previously known as FKHR), FOXO3 (previously known as FKHRL1), FOXO4 (previously known as AFX) and FOXO6.
FOXO family
FOXO proteins are conserved from worm to human. To date, only one FOXO species has been identified in invertebrates (called dauer formation-16 in Caenorhabditis elegans and dFOXO in Drosophila). In mammals, four subfamily members have been identified: FOXO1 (previously known as FKHR), FOXO3 (previously known as FKHRL1), FOXO4 (previously known as AFX) and FOXO6.
PMID:18391973
FOXO1 (mol)
FOXO3
FOXO4
FOXO6
Insulin superfamily genes are ubiquitous in vertebrates, and have been identified in invertebrates, including insects, molluscs, and the nematode Caenorhabditis elegans. Seven members of the insulin superfamily have been identified in humans, including insulin, insulin-like growth factors (IGFs) I and II, relaxins HI and HII, early placenta insulin-like peptide (EPIL), and relaxin-like factor.
insulin family
Insulin superfamily genes are ubiquitous in vertebrates, and have been identified in invertebrates, including insects, molluscs, and the nematode Caenorhabditis elegans. Seven members of the insulin superfamily have been identified in humans, including insulin, insulin-like growth factors (IGFs) I and II, relaxins HI and HII, early placenta insulin-like peptide (EPIL), and relaxin-like factor.
PMID:11274053
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
B7.1/B7.2
CD80/CD86
B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively.
PMID:14647476
Arrow/Lrp5/Lrp6 is a subfamily of the LDL receptor (LDLR) family. Arrow, and also its counterparts LRP5 and LRP6 in mammals and in frogs, appears to function as a coreceptor for Wnt together with the seven-transmembrane receptor Frizzled (frz) in forming the Wnt receptor signaling complex.
Arrow/LRP5/LRP6
Arrow/Lrp5/Lrp6 is a subfamily of the LDL receptor (LDLR) family. Arrow, and also its counterparts LRP5 and LRP6 in mammals and in frogs, appears to function as a coreceptor for Wnt together with the seven-transmembrane receptor Frizzled (frz) in forming the Wnt receptor signaling complex.
PMID:12045102
PMID:15084453
Lrp5 and Lrp6 are highly homologous, and are widely co-expressed during embryogenesis and in adult tissues. An orthologue in Drosophila melanogaster is known as arrow, a gene that functions in the canonical Wnt signaling pathway.
LRP5/LRP6
Lrp5 and Lrp6 are highly homologous, and are widely co-expressed during embryogenesis and in adult tissues. An orthologue in Drosophila melanogaster is known as arrow, a gene that functions in the canonical Wnt signaling pathway.
PMID:12045102
PMID:15084453
GRK2
beta-arrestin 1
beta-arrestin 2
Dlp/Dally
ETV6
TEL
TEL1
Kif3A
alpha PIX
The BMP-1/TLD metalloproteinases, conserved in species ranging from Drosophila to humans, act in dorsal-ventral patterning via activation of BMP2, BMP4 (vertebrates) and Dpp (arthropods).
There are four mammalian BMP-1/TLD-like proteinases, including BMP-1/mTLD, which is encoded by alternatively spliced mRNA produced by the Bmp1 gene, and TLL1 and TLL2, which are genetically distinct.
bone morphogenetic protein-1/tolloid family
BMP-1/TLD family
The BMP-1/TLD metalloproteinases, conserved in species ranging from Drosophila to humans, act in dorsal-ventral patterning via activation of BMP2, BMP4 (vertebrates) and Dpp (arthropods).
There are four mammalian BMP-1/TLD-like proteinases, including BMP-1/mTLD, which is encoded by alternatively spliced mRNA produced by the Bmp1 gene, and TLL1 and TLL2, which are genetically distinct.
PMID:17560775
PMID:19429706
CDMP-1
Growth/differentiation factor-5
cartilage-derived morphogenetic protein-1
GDF-5
BMP-13
Bone morphogenetic protein-13
CDMP-2
Growth/differentiation factor 6
cartilage-derived morphogenetic protein-2
GDF-6
BMP-12
Bone morphogenetic protein-12
Growth/differentiation factor 7
GDF-7
Growth/differentiation factor-8
myostatin
GDF-8
Growth/differentiation factor-9
GDF-9
Growth/differentiation factor-3
Vgr-2
GDF-3
BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-2, BMP-4, and the Drosophila Dpp form one subgroup.
BMP-2/4 group
BMP-2 subfamily
BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-2, BMP-4, and the Drosophila Dpp form one subgroup.
PMID:15871923
PMID:9720756
PMID:9759503
BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-5, BMP-6, BMP-7 (OP-1), BMP-8 (OP-2), and the Drosophila Gbb form one subgroup.
OP-1 group
BMP-5 subfamily
BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-5, BMP-6, BMP-7 (OP-1), BMP-8 (OP-2), and the Drosophila Gbb form one subgroup.
PMID:15871923
PMID:9720756
PMID:9759503
BMP-related proteins can be subdivided into several groups based on their structures and functions. GDF-5 (CDMP- 1), GDF-6 (CDMP-2 or BMP-13), and GDF-7 (BMP-12) form one sugroup.
GDF-5 subfamily
BMP-related proteins can be subdivided into several groups based on their structures and functions. GDF-5 (CDMP- 1), GDF-6 (CDMP-2 or BMP-13), and GDF-7 (BMP-12) form one sugroup.
PMID:15871923
PMID:9720756
PMID:9759503
Nucleoside diphoshate kinases (NDKs), an evolutionarily conserved family of proteins, synthesize nucleoside triphosphates from nucleoside diphosphates and ATP. To date, eight human NDK homologues have been identified.
EC:2.7.4.6
GO:0004550
NDK
NDP kinase
NME
Nm23
nucleoside diphosphate kinase
Nucleoside diphoshate kinases (NDKs), an evolutionarily conserved family of proteins, synthesize nucleoside triphosphates from nucleoside diphosphates and ATP. To date, eight human NDK homologues have been identified.
PMID:11768308
PMID:16313181
negative elongation factor
NELF
Translation initiation in eukaryotes is an intricate process requiring at least 11 eukaryotic initiation factors (eIFs).
eukaryotic initiation factor
eIF
Translation initiation in eukaryotes is an intricate process requiring at least 11 eukaryotic initiation factors (eIFs).
PMID:11426420
PMID:12581660
PMID:14635255
SIII
Elongin
Heterogeneous nuclear ribonucleoprotein
A role played by the entity which catalyses the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
EC:2.3.1.85
related molecular function GO:0004312
fatty acid synthase
EC:1.11.1.9
Cellular glutathione peroxidase
GSHC
GSHPx-1
Glutathione peroxidase 1
glutathione peroxidase monomer
Glutathione peroxidase
GTR1
Glucose transporter type 1, erythrocyte/brain
HepG2 glucose transporter
Solute carrier family 2, facilitated glucose transporter, member 1
GLUT1
GTR2
Glucose transporter type 2, liver
Solute carrier family 2, facilitated glucose transporter, member 2
GLUT2
GTR4
Glucose transporter type 4, insulin-responsive
Solute carrier family 2, facilitated glucose transporter, member 4
GLUT4
Solute carrier family 25, member 15
Mitochondrial ornithine transporter 1
57 kDa RNA-binding protein PPTB-1
Heterogeneous nuclear ribonucleoprotein I
PTB
hnRNP I
Polypyrimidine tract-binding protein 1
CSA-19
60S ribosomal protein L10a
23 kDa highly basic protein
60S ribosomal protein L13a
Q9UNX3
60S ribosomal protein L26-like 1
40S small ribosomal protein 27A
40S ribosomal protein S27a
P18077
60S ribosomal protein L35a
60S ribosomal protein L37a
Negative elongation factor E
RD protein
NELF-E
Laminin receptor homolog
QM protein
Tumor suppressor QM
60S ribosomal protein L10
60S ribosomal protein L11
P30050
60S ribosomal protein L12
Breast basic conserved protein 1
60S ribosomal protein L13
CAG-ISL 7
60S ribosomal protein L14
P39030
60S ribosomal protein L15
L23
60S ribosomal protein L17
Q07020
60S ribosomal protein L18
60S ribosomal protein L19
Q02543
60S ribosomal protein L18a
P46778
60S ribosomal protein L21
EAP
EBER associated protein
Epstein-Barr virus small RNA associated protein
Heparin binding protein HBp15
60S ribosomal protein L22
L17
60S ribosomal protein L23
L30
60S ribosomal protein L24
60S ribosomal protein L26
60S ribosomal protein L27
P46779
60S ribosomal protein L28
Cell surface heparin binding protein HIP
60S ribosomal protein L29
P46776
60S ribosomal protein L27a
P29316
60S ribosomal protein L23a
60S ribosomal protein L30
60S ribosomal protein L31
60S ribosomal protein L32
P49207
60S ribosomal protein L34
P42766
60S ribosomal protein L35
Q9Y3U8
60S ribosomal protein L36
G1.16
60S ribosomal protein L37
60S ribosomal protein L38
60S ribosomal protein L39
Q92901
60S ribosomal protein L3-like
HIV-1 TAR RNA binding protein B
TARBP-B
60S ribosomal protein L3
CEP52
60S ribosomal protein L40
HG12
60S ribosomal protein L41
60S ribosomal protein L44
60S ribosomal protein L36a
L1
60S ribosomal protein L4
P46777
60S ribosomal protein L5
Neoplasm-related protein C140
TAX-responsive enhancer element binding protein 107
TAXREB107
60S ribosomal protein L6
PLA-X polypeptide
Surfeit locus protein 3
60S ribosomal protein L7a
P18124
60S ribosomal protein L7
60S ribosomal protein L8
60S ribosomal protein L9
P32969
60S ribosomal protein L9
L10E
60S acidic ribosomal protein P0
P05386
60S acidic ribosomal protein P1
P05387
60S acidic ribosomal protein P2
ROA0
hnRNP A0
Heterogeneous nuclear ribonucleoprotein A0
Helix-destabilizing protein
ROA1
Single-strand binding protein
hnRNP A1
hnRNP core protein A1
Heterogeneous nuclear ribonucleoprotein A1
ROA2
hnRNP A2
hnRNP A2 / hnRNP B1
Heterogeneous nuclear ribonucleoproteins A2/B1
D10S102
ROA3
hnRNP A3
Heterogeneous nuclear ribonucleoprotein A3
ROC
hnRNP C1 / hnRNP C2
hnRNP C1/C2
Heterogeneous nuclear ribonucleoproteins C1/C2
AU-rich element RNA-binding protein 1
ROD
hnRNP D0
Heterogeneous nuclear ribonucleoprotein D0
ROF
hnRNP F
Heterogeneous nuclear ribonucleoprotein F
Glycoprotein p43
RNA binding motif protein, X chromosome
ROG
hnRNP G
Heterogeneous nuclear ribonucleoprotein G
ROH1
hnRNP H
Heterogeneous nuclear ribonucleoprotein H
FTP-3
ROH2
hnRNP H'
Heterogeneous nuclear ribonucleoprotein H'
CSBP
DC-stretch binding protein
ROK
TUNP
Transformation upregulated nuclear protein
hnRNP K
Heterogeneous nuclear ribonucleoprotein K
ROL
hnRNP L
Heterogeneous nuclear ribonucleoprotein L
ROM
hnRNP M
Heterogeneous nuclear ribonucleoprotein M
ROR
hnRNP R
Heterogeneous nuclear ribonucleoprotein R
ROU
SAF-A
Scaffold attachment factor A
hnRNP U
Heterogenous nuclear ribonucleoprotein U
40S small ribosomal protein 10
40S ribosomal protein S10
40S small ribosomal protein 11
40S ribosomal protein S11
40S small ribosomal protein 12
40S ribosomal protein S12
40S small ribosomal protein 13
40S ribosomal protein S13
40S small ribosomal protein 14
40S ribosomal protein S14
40S small ribosomal protein 15
RIG protein
40S ribosomal protein S15
40S small ribosomal protein 16
40S ribosomal protein S16
40S small ribosomal protein 17
40S ribosomal protein S17
40S small ribosomal protein 18
KE-3
KE3
40S ribosomal protein S18
40S small ribosomal protein 19
40S ribosomal protein S19
40S small ribosomal protein 1A
40S ribosomal protein S15a
40S small ribosomal protein 20
40S ribosomal protein S20
40S small ribosomal protein 21
40S ribosomal protein S21
40S small ribosomal protein 23
40S ribosomal protein S23
40S small ribosomal protein 24
S19
40S ribosomal protein S24
40S small ribosomal protein 25
40S ribosomal protein S25
40S small ribosomal protein 26
40S ribosomal protein S26
40S small ribosomal protein 27
MPS-1
Metallopan-stimulin 1
40S ribosomal protein S27
40S small ribosomal protein 28
40S ribosomal protein S28
40S small ribosomal protein 29
40S ribosomal protein S29
40S small ribosomal protein 2
LLREP3 protein
S4
40S ribosomal protein S2
40S small ribosomal protein 30
40S ribosomal protein S30
40S small ribosomal protein 3A
40S ribosomal protein S3a
40S small ribosomal protein 3
40S ribosomal protein S3
40S small ribosomal protein 4Y
40S ribosomal protein S4, Y isoform
40S small ribosomal protein 4
SCR10
Single copy abundant mRNA protein
40S ribosomal protein S4, X isoform
40S small ribosomal protein 5
40S ribosomal protein S5
40S small ribosomal protein 7
40S ribosomal protein S7
40S small ribosomal protein 8
40S ribosomal protein S8
40S small ribosomal protein 9
40S ribosomal protein S9
40S small ribosomal protein P4
laminin receptor
40S ribosomal protein SA
Transcription elongation factor A protein 1
Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)
Transcription elongation factor S-II protein 1
Transcription elongation factor TFIIS.o
TFIIS protein
General transcription factor TFIIB
RNA polymerase II alpha initiation factor
S300-II
Transcription factor E
Transcription initiation factor IIB
TFIIB
IMR:0011979
EIF- 2alpha
EIF-2A
Eukaryotic translation initiation factor 2 alpha subunit
Eukaryotic translation initiation factor 2 subunit 1
eIF-2-alpha
translation initiation factor 2 alpha subunit
translation initiation factor 2, subunit 1
eIF2-alpha
Eukaryotic translation initiation factor 2 subunit 2
eIF-2-beta
eukaryotic translation initiation factor 2 beta subunit
eukaryotic translation initiation factor 2, subunit 2
eIF2-beta
Eukaryotic translation initiation factor 2 subunit 3
eIF-2-gamma
eukaryotic translation initiation factor 2 gamma subunit
eukaryotic translation initiation factor 2, subunit 3
eIF2-gamma
Translation initiation factor eIF-2B alpha subunit
eIF-2B GDP-GTP exchange factor
eIF-2B GDP-GTP exchange factor, alpha subunit
translation initiation factor 2B alpha subunit
eIF2B-alpha
S20I15
S20III15
Translation initiation factor eIF-2B beta subunit
eIF-2B GDP-GTP exchange factor
eIF-2B GDP-GTP exchange factor, beta subunit
translation initiation factor 2B beta subunit
eIF2B-beta
Translation initiation factor eIF-2B delta subunit
eIF-2B GDP-GTP exchange factor
eIF-2B GDP-GTP exchange factor, delta subunit
translation initiation factor 2B delta subunit
eIF2B-delta
Translation initiation factor eIF-2B epsilon subunit
eIF-2B GDP-GTP exchange factor
eIF-2B GDP-GTP exchange factor, epsilon subunit
translation initiation factor 2B epsilon subunit
eIF2B-epsilon
Translation initiation factor eIF-2B gamma subunit
eIF-2B GDP-GTP exchange factor
eIF-2B GDP-GTP exchange factor, gamma subunit
translation initiation factor 2B gamma subunit
eIF2B-gamma
This subunit is not part of the Saccharomyces cerevisiae core eIF3 complex.
Possible eukaryotic translation initiation factor 3 30 kDa subunit
eIF-3 30 kDa
eIF-3 alpha
eIF3 p35
eukaryotic translation initiation factor 3 subunit 1
eIF3j
This subunit is not part of the Saccharomyces cerevisiae core eIF3 complex.
PMID:11426420
Eukaryotic translation initiation factor 3 39 kDa subunit
Suppressor of uncontrolled mitosis 1
TGF-beta receptor interacting protein 1
TRIP-1
Translation initiation factor eIF3, p39 subunit
eIF-3 beta
eIF3 p36
eIF3 p39
eukaryotic translation initiation factor 3 subunit 2
eIF3i
Eukaryotic translation initiation factor 3 RNA-binding subunit
Translation initiation factor eIF3, p33 subunit
eIF-3 RNA-binding subunit
eIF-3 delta
eIF3 p33
eIF3 p42
eIF3 p44
eukaryotic translation initiation factor 3 subunit 4
eIF3g
eIF-3 epsilon
eIF3 p47
eIF3 p47 subunit
eukaryotic translation initiation factor 3 subunit 5
eIF3f
Cell cycle regulation and translation initiation protein
Eukaryotic translation initiation factor 3 90 kDa subunit
eIF-3 eta
eIF3 p110
eIF3 p116
eIF3 p90
eukaryotic translation initiation factor 3 subunit 9
eIF3b
eIF-3 gamma
eIF3 p40
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eIF3h
Translation initiation factor eIF3, p110 subunit
eIF-3 theta
eIF3 p110
eIF3 p167
eIF3 p180
eIF3 p185
eukaryotic translation initiation factor 3 subunit 10
eIF3a
eIF-3 zeta
eIF3 p66
eukaryotic translation initiation factor 3 subunit 7
eIF3d
Eukaryotic translation initiation factor 3 93 kDa subunit
Eukaryotic translation initiation factor 3 subunit 8
Nuclear transport protein NIP1
eIF3 p110
eIF3 p93
eIF3c
Eukaryotic translation initiation factor 3 subunit 6
Mammary tumor-associated protein INT-6
Viral integration site protein INT-6
eIF-3 p48
eIF3e
ARG134
Eukaryotic translation initiation factor 3 subunit 11
HSPC029
Muscle specific gene M9 protein
PTD001
eIF-3 p25
eukaryotic translation initiation factor 3 subunit 11
eIF3k
Eukaryotic translation initiation factor 1A, X-chromosomal
Eukaryotic translation initiation factor 1A, Y-chromosomal
eIF-1A
eIF-1A X isoform
eIF-1A Y isoform
eIF-4C
eukaryotic translation initiation factor 1A
eIF1A
eIF-4A-I
eIF4AI
eukaryotic initiation factor 4A-I
eIF4A-I
IMR:0011606
eIF-4A-II
eIF4AII
eukaryotic initiation factor 4A-II
eIF4A-II
IMR:0011556
IF4E
eIF-4E
eIF-4F 25 kDa subunit
eukaryotic translation initiation factor 4E
mRNA cap-binding protein
eIF4E
P220
eIF-4-gamma 1
eIF-4G
eIF-4G1
eukaryotic translation initiation factor 4 gamma 1
eIF4GI
eIF-4B
eukaryotic translation initiation factor 4B
eIF4B
Williams-Beuren syndrome chromosome region 1 protein
eIF-4H
eukaryotic translation initiation factor 4H
eIF4H
Eukaryotic translation initiation factor 5
eIF-5
eIF5
EloA
Elongin 110 kDa subunit
Elongin A
MSTP059
RNA polymerase II transcription factor SIII subunit A1
SIII p110
Transcription elongation factor B polypeptide 3
Elongin A1 protein
EloC
Elongin 15 kDa subunit
Elongin C
RNA polymerase II transcription factor SIII subunit C
SIII p15
Transcription elongation factor B polypeptide 1
Elongin B protein
EloB
Elongin 18 kDa subunit
Elongin B
RNA polymerase II transcription factor SIII subunit B
SIII p18
Transcription elongation factor B polypeptide 2
Elongin C protein
NELF-A
Negative elongation factor A
P/OKCL.15
Wolf-Hirshhorn syndrome candidate 2 protein
mWHSC2
NELF-A protein
Cofactor of BRCA1
NELF-B
Negative elongation factor B
NELF-B protein
HSPC130
NELF-C/D
Negative elongation factor C/D
TH1-like protein
NELF-C/D protein
NDKA
NDKB
NDK3
NDKM
EC:3.1.4.35
GO:0004116
cGMP-specific PDE
cGMP-specific phosphodiesterase
cyclic GMP phosphodiesterase
cGMP phosphodiesterase
importin
exportin
Naturally occurring compounds derived from the parent C20 acid, prostanoic acid.
CAS:11000-26-3
prostaglandin
Any icosanoid from that family of C20 polyunsaturated fatty acids and their derivatives generated by leukocytes from arachidonic acid, each member having four double bonds of which three are conjugated.
leukotriene
3',5'-Cyclic AMP
Adenosine 3',5'-phosphate
Cyclic AMP
Cyclic adenylic acid
cAMP
IMR:0200372
3',5'-Cyclic GMP
Cyclic GMP
Guanosine 3',5'-cyclic monophosphate
Guanosine 3',5'-cyclic phosphate
cGMP
DAG
DG
Diglyceride
diacylglyceride
diacylglycerol
IMR:0200332
1,4,5-InsP3
1D-myo-Inositol 1,4,5-trisphosphate
D-myo-Inositol 1,4,5-trisphosphate
Inositol 1,4,5-Trisphosphate
IP3
IMR:0200210
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
D-myo-Inositol 1,3,4,5-tetrakisphosphate
Inositol 1,3,4,5-tetrakisphosphate
Ins(1,3,4,5)P4
IP4
CHEBI:26764
steroid hormone
4-Pregnene-3,20-dione
progesterone
stress hormone
glucocorticoid
CHEBI:25354
mineralocorticoid
vitamin D
Retin A
Tretinoin
all-trans-Retinoic Acid
all-trans-Vitamin A acid
vitamin A acid
retinoic acid
MeSH:D013963
thyroid hormone (substance)
MeSH:D013974
3,5,3'5'-Tetraiiodo-L-thyronine
L-Thyroxine
Levothyroxin
O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine
T4 Thyroid Hormone
thyroxine
MeSH:D014284
3,3'5-Triiodo-L-thyronine
3,5,3'-Triiodo-L-thyronine
3,5,3'-Triiodothyronine
L-3,5,3'-Triiodothyronine
Liothyronine
T3 Thyroid Hormone
Triiodothyronine
triiodothyronine
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
MeSH:D002116
calcitonin
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
MeSH:D002116
A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
MeSH:D002766
CCK
cholecystokinin
A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
MeSH:D002766
A gastrointestinal peptide hormone of about 43-amino acids.
MeSH:D005749
GIP
gastric inhibitory polypeptide
A gastrointestinal peptide hormone of about 43-amino acids.
MeSH:D005749
A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.
MeSH:D009037
motilin
A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.
MeSH:D009037
A polypeptide hormone that originates in the hypothalamus and stimulates the secretion of prolactin in the pituitary gland.
MeSH:D011390
PRF
PRH
PrRP
prolactin-releasing factor
rolactin-releasing peptide
prolactin-releasing hormone
A polypeptide hormone that originates in the hypothalamus and stimulates the secretion of prolactin in the pituitary gland.
MeSH:D011390
A tripeptide hormone that originates in the HYPOTHALAMUS and stimulates the secretion of THYROTROPIN from the PITUITARY GLAND. In humans, it also acts as a prolactin-releasing factor. It is also a neurotransmitter in the central nervous system.
MeSH:D013973
5-oxo-prolyl-histidyl-prolinamide
TRH
protirelin
thyroliberin
thyrotropin-releasing hormone
A tripeptide hormone that originates in the HYPOTHALAMUS and stimulates the secretion of THYROTROPIN from the PITUITARY GLAND. In humans, it also acts as a prolactin-releasing factor. It is also a neurotransmitter in the central nervous system.
MeSH:D013973
Hypothalamic peptide that regulates the synthesis and secretion of GROWTH HORMONE in the anterior pituitary gland.
MeSH:D013007
GHRH
SRH
Somatoliberin
somatotropin-releasing hormone
growth hormone-releasing hormone
Hypothalamic peptide that regulates the synthesis and secretion of GROWTH HORMONE in the anterior pituitary gland.
MeSH:D013007
MSHRH
MSH-releasing hormone
A peptide hormone of about 22 amino acids. It is derived from PRO-OPIOMELANOCORTIN and has natriuretic activity.
MeSH:D019824
beta-Melanotropin
beta-MSH
A peptide hormone of about 22 amino acids. It is derived from PRO-OPIOMELANOCORTIN and has natriuretic activity.
MeSH:D019824
IMR:0200455
MeSH:D008550
Melatonin
N-Acetyl-5-methoxytryptamine
melatonin
Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.
MeSH:D019886
GRP
gastrin-releasing peptide
Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.
MeSH:D019886
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors ( RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
MeSH:D014660
VIP
vasoactive intestinal peptide
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors ( RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
MeSH:D014660
HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.
MeSH:D005768
Enteric Hormone
Intestinal Hormone
gastrointestinal hormones
HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.
MeSH:D005768
A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.
MeSH:D019894
peptide YY
A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.
MeSH:D019894
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level.
MeSH:D012633
secretin
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level.
MeSH:D012633
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
MeSH:D010187
pancreatic hormone
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
MeSH:D010187
A pancreatic peptide hormone of about 29 amino acids secreted by PANCREATIC ALPHA CELLS. It has an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes.
MeSH:D005934
glucagon
A pancreatic peptide hormone of about 29 amino acids secreted by PANCREATIC ALPHA CELLS. It has an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes.
MeSH:D005934
Hormones isolated from the hypothalamus which exercise control over other organs, primarily the pituitary gland. Well-known members include certain pituitary hormone-releasing hormones and pituitary hormone release inhibiting hormones. Vasopressin and oxytocin which are found in the posterior pituitary may also be secreted by the hypothalamus but are not grouped here ( PITUITARY HORMONES, POSTERIOR).
MeSH:D007028
hypothalamic hormone
Hormones isolated from the hypothalamus which exercise control over other organs, primarily the pituitary gland. Well-known members include certain pituitary hormone-releasing hormones and pituitary hormone release inhibiting hormones. Vasopressin and oxytocin which are found in the posterior pituitary may also be secreted by the hypothalamus but are not grouped here ( PITUITARY HORMONES, POSTERIOR).
MeSH:D007028
Parathormone
parathyroid hormone
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe.
MeSH:D010907
pituitary hormone
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe.
MeSH:D010907
Hormones produced by the placenta include CHORIONIC GONADOTROPIN, and PLACENTAL LACTOGEN. Not include steroid hormones ( ESTROGENS; PROGESTERONE).
MeSH:D010926
placental hormone, peptide
Hormones produced by the placenta include CHORIONIC GONADOTROPIN, and PLACENTAL LACTOGEN. Not include steroid hormones ( ESTROGENS; PROGESTERONE).
MeSH:D010926
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis ( GONADOTROPINS, PITUITARY) and the placenta ( CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
MeSH:D006062
gonadotropin
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis ( GONADOTROPINS, PITUITARY) and the placenta ( CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
MeSH:D006062
thymus hormone
Polypeptide hormones produced in the hypothalamus which inhibit the release of pituitary hormones. Used for PHRIH in general or for which there is no specific heading.
MeSH:D010905
PHRIH
pituitary hormone release inhibiting hormone
Polypeptide hormones produced in the hypothalamus which inhibit the release of pituitary hormones. Used for PHRIH in general or for which there is no specific heading.
MeSH:D010905
MSHRIH
Melanostatin
MSH release-inhibiting hormone
PIH
prolactin release-inhibiting hormone
Hormones released by one structure (e.g., the hypothalamus or the thyroid gland) that effect the secretion of hormones from the pituitary gland.
MeSH:D010906
PHRH
pituitary hormone-releasing hormone
Hormones released by one structure (e.g., the hypothalamus or the thyroid gland) that effect the secretion of hormones from the pituitary gland.
MeSH:D010906
CRH
Corticotropin-releasing factor
corticotropin-releasing hormone
A decapeptide hormone released by the hypothalamus. It stimulates the synthesis and secretion of both FOLLICLE STIMULATING HORMONE and luteinizing hormone (LH) from the pituitary gland.
MeSH:D007987
FSH-Releasing Hormone
GnRH
LH-Releasing Hormone
LHRH
gonadoliberin
gonadorelin
gonadotropin-releasing hormone
A decapeptide hormone released by the hypothalamus. It stimulates the synthesis and secretion of both FOLLICLE STIMULATING HORMONE and luteinizing hormone (LH) from the pituitary gland.
MeSH:D007987
Hormones secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR).
MeSH:D010908
pituitary hormone, anterior
Hormones secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR).
MeSH:D010908
The alpha chain of pituitary glycoprotein hormones ( THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
MeSH:D015292
glycoprotein hormone, alpha subunit
The alpha chain of pituitary glycoprotein hormones ( THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
MeSH:D015292
Hormones secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation ( OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids ( ESTROGENS; PROGESTERONE; ANDROGENS).
MeSH:D006065
gonadotropin, pituitary
Hormones secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation ( OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids ( ESTROGENS; PROGESTERONE; ANDROGENS).
MeSH:D006065
A major gonadotropin secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D005640
FSH
follitropin
follicle stimulating hormone
A major gonadotropin secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D005640
A major gonadotropin secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D005640
LH
lutropin
luteinizing hormone
A major gonadotropin secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D005640
A polypeptide that is secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
MeSH:D013006
GH
somatotropin
growth hormone (mol)
A polypeptide that is secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
MeSH:D013006
Hormones released from the posterior lobe of the pituitary, including vasopressin (antidiuretic hormone) and oxytocin. They are formed in the neuronal cells of the hypothalamic nuclei and stored in nerve cell endings in the posterior pituitary (neurohypophysis).
MeSH:D010909
Pituitrin
pituitary hormone, posterior
Hormones released from the posterior lobe of the pituitary, including vasopressin (antidiuretic hormone) and oxytocin. They are formed in the neuronal cells of the hypothalamic nuclei and stored in nerve cell endings in the posterior pituitary (neurohypophysis).
MeSH:D010909
A nonapeptide posterior pituitary hormone that causes UTERINE CONTRACTIONS and stimulates MILK EJECTION.
MeSH:D010121
OXT
Ocytocin
Pitocin
oxtocin
oxytocin
A nonapeptide posterior pituitary hormone that causes UTERINE CONTRACTIONS and stimulates MILK EJECTION.
MeSH:D010121
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production.
MeSH:D010928
Choriomammotropin
placental lactogen
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production.
MeSH:D010928
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D006063
CG
chorionic gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D006063
Thymulin
thymic factor, circulating
thymopoietin
thymosin
O-Acetylcholine
acetylcholine
IMR:0200003
2-(3,4-Dihydroxyphenyl)ethylamine
3,4-Dihydroxyphenethylamine
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)benzene-1,2-diol
Dopamine
dopamine
IMR:0200335
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
L-Adrenaline
adrenalin
IMR:0200116
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
Arterenol
L-Noradrenaline
LEVOPHED (TN)
Norepinephrine
noradrenalin
IMR:0200145
4-Amino-butanoic acid
4-aminobutanoic acid
GABA
gamma-aminobutyric acid
IMR:0200057
Aminoacetic acid
Gly
Glycine
glycine
IMR:0200156
L-Glutamate
L-Glutamic acid
L-Glutaminic acid
glutamic acid
IMR:0200071
2-aminoethanesulfonic acid
Taurine
taurine
1-(4-Hydroxyphenyl)-2-aminoethanol
p-hydroxyphenylethanolamine
octopamine
IMR:0200412
3-(2-Aminoethyl)-1H-indol-5-ol
5-Hydroxytryptamine
Serotonin
enteramine
serotonin
IMR:0200018
2-(p-Hydroxyphenyl)ethylamine
Tyramine
tyramine
IMR:0200295
1H-Imidazole-4-ethanamine
2-(4-Imidazolyl)ethylamine
Histamine
histamine
Hypertensin
angiotensin
angiotensin I
angiotensin III
beta-endorphin
MeSH:D001920
bradykinin
kallidin
Somatomedin is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division. In this way, they mediate the effect of somatotropin (also known as growth hormone).
They have similar biological effects to somatotropin.
Three forms include:
* somatomedin A, which is another name for insulin-like growth factor 2
* somatomedin B, which is derived from vitronectin
* somatomedin C, which is another name for insulin-like growth factor 1
MeSH:D013002
somatomedin
Somatomedin is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division. In this way, they mediate the effect of somatotropin (also known as growth hormone).
They have similar biological effects to somatotropin.
Three forms include:
* somatomedin A, which is another name for insulin-like growth factor 2
* somatomedin B, which is derived from vitronectin
* somatomedin C, which is another name for insulin-like growth factor 1
Wikipedia:http://en.wikipedia.org/wiki/Somatomedin
IGF-I
insulin-like growth factor I
IGF-II
insulin-like growth factor II
MeSH:D000809
angiotensin
angiotensin II
opioid peptide
endorphin
alpha-endorphin
gamma-endorphin
enkephalin
leucine enkephalin
adrenorphin
alpha-neoendorphin
rimorphin
The kinins are pharmacologically active polypeptides released in the tissues and body fluids as a result of the enzymatic action of kallikreins on kininogens. The kinin family includes bradykinin (Arg-Pro-Pro-gly-Phe-Ser-Pro-Phe-Arg), kallidin (Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) and methionyl-lysyl-bradykinin (Met-Lys-Arg-Pro-Pro-Gly-Phe-Arg).
MeSH:D007705
plasmakinin
kinin
The kinins are pharmacologically active polypeptides released in the tissues and body fluids as a result of the enzymatic action of kallikreins on kininogens. The kinin family includes bradykinin (Arg-Pro-Pro-gly-Phe-Ser-Pro-Phe-Arg), kallidin (Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) and methionyl-lysyl-bradykinin (Met-Lys-Arg-Pro-Pro-Gly-Phe-Arg).
PMID:16513476
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
MeSH:D016232
endothelin
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
MeSH:D016232
ET-1
endothelin-1
ET-2
endothelin-2
ET-3
endothelin-3
kinesin superfamily
kinesin-like protein
A lactogenic hormone secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
MeSH:D011388
PRL
prolactin
A lactogenic hormone secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
MeSH:D011388
An anterior pituitary hormone that stimulates the secretion of CORTICOSTEROIDS and induces growth of the ADRENAL CORTEX. It is a single-chain polypeptide of about 39 amino acids, the first 24 of which are identical in all species. This 24-amino acid segment is said to be responsible for the biological activity of the peptide while the remaining 15-amino acid segment is said to be necessary for any immunological specificity.
MeSH:D000324
ACTH
Adrenocorticotropic hormone
corticotropin
An anterior pituitary hormone that stimulates the secretion of CORTICOSTEROIDS and induces growth of the ADRENAL CORTEX. It is a single-chain polypeptide of about 39 amino acids, the first 24 of which are identical in all species. This 24-amino acid segment is said to be responsible for the biological activity of the peptide while the remaining 15-amino acid segment is said to be necessary for any immunological specificity.
MeSH:D000324
A 13-amino acid peptide derived from the ANTERIOR PITUITARY GLAND in man and from the pars intermedia in lower vertebrates. Its amino acid sequence is identical to the first 13 amino acids of ACTH. It influences the formation of deposition of MELANIN in the body.
MeSH:D000521
alpha-MSH
A 13-amino acid peptide derived from the ANTERIOR PITUITARY GLAND in man and from the pars intermedia in lower vertebrates. Its amino acid sequence is identical to the first 13 amino acids of ACTH. It influences the formation of deposition of MELANIN in the body.
MeSH:D000521
Lipotropic or pituitary lipotropic hormone. A pituitary hormone mobilizing fat from adipose tissue. Beta-lipotropin is a single-chain peptide of about 90 residues that contains the sequences of endorphins and metenkephalin, and may be a precursor of beta-melanotropin and beta-endorphin. Gamma-lipotropin is shorter and is identical in sequence to the first 58 residues of beta-lipotropin. Both contain sequences common to ACTH and beta-melanotropin.
MeSH:D008083
LPH
lipotropin
Lipotropic or pituitary lipotropic hormone. A pituitary hormone mobilizing fat from adipose tissue. Beta-lipotropin is a single-chain peptide of about 90 residues that contains the sequences of endorphins and metenkephalin, and may be a precursor of beta-melanotropin and beta-endorphin. Gamma-lipotropin is shorter and is identical in sequence to the first 58 residues of beta-lipotropin. Both contain sequences common to ACTH and beta-melanotropin.
MeSH:D008083
Peptide hormones secreted by the intermediate lobe of the pituitary that stimulate melanin release and dispersal. Melanocyte-stimulating hormones are also found in the brain where they are presumed to play a signaling role.
MeSH:D009074
Intermedin
Melanotropin
MSH
Peptide hormones secreted by the intermediate lobe of the pituitary that stimulate melanin release and dispersal. Melanocyte-stimulating hormones are also found in the brain where they are presumed to play a signaling role.
MeSH:D009074
A peptide hormone of about 11 amino acids derived from PRO-OPIOMELANOCORTIN that has natriuretic activity.
MeSH:D019825
gamma-Melanotropin
gamma-MSH
A peptide hormone of about 11 amino acids derived from PRO-OPIOMELANOCORTIN that has natriuretic activity.
MeSH:D019825
A glycoprotein hormone secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones ( THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D013972
TSH
thyroid-stimulating hormone
thyrotropin
A glycoprotein hormone secreted by the adenohypophysis ( PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones ( THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
MeSH:D013972
Octapeptide antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (chemical composition varies with species). They control water metabolism and balance by regulating LUNG; GILLS; KIDNEY; etc., and water loss, and also contract smooth muscle. They may also be NEUROTRANSMITTERS.
MeSH:D014667
ADH
Antidiuretic hormone
VP
vasopressin
Octapeptide antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (chemical composition varies with species). They control water metabolism and balance by regulating LUNG; GILLS; KIDNEY; etc., and water loss, and also contract smooth muscle. They may also be NEUROTRANSMITTERS.
MeSH:D014667
karyopherin alpha
importin alpha
karyopherin beta1
importin beta
CAS/CSE
Regulator of chromosome condensation
RCC1
GO:0005098
Ran GTPase-activating protein
Ran GAP
GO:0008349
MAP kinase kinase kinase kinase
MAPKKKK
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
MeSH:D005755
gastrin
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
MeSH:D005755
A 36-amino acid polypeptide secreted by the PANCREAS that has physiological regulatory functions. Plasma pancreatic polypeptide increases after ingestion of food, with age, and in disease states. A lack of pancreatic polypeptide in the ISLETS OF LANGERHANS has been associated with the OBESITY in rats and mice.
MeSH:D010191
pancreatic polypeptide
A 36-amino acid polypeptide secreted by the PANCREAS that has physiological regulatory functions. Plasma pancreatic polypeptide increases after ingestion of food, with age, and in disease states. A lack of pancreatic polypeptide in the ISLETS OF LANGERHANS has been associated with the OBESITY in rats and mice.
MeSH:D010191
A polypeptide hormone produced in the HYPOTHALAMUS, and other tissues and organs. It inhibits the release of growth hormone ( SOMATOTROPIN), and also modulates important physiological functions of the kidney, pancreas, and gastrointestinal tract. Somatostatin receptors are widely expressed throughout the body. Somatostatin also acts as a neurotransmitter in the central and peripheral nervous systems.
MeSH:D013004
SRIH
growth hormone-release inhibiting factor
growth hormone-release inhibiting hormone
somatotropin release-inhibiting hormone
somatostatin
A polypeptide hormone produced in the HYPOTHALAMUS, and other tissues and organs. It inhibits the release of growth hormone ( SOMATOTROPIN), and also modulates important physiological functions of the kidney, pancreas, and gastrointestinal tract. Somatostatin receptors are widely expressed throughout the body. Somatostatin also acts as a neurotransmitter in the central and peripheral nervous systems.
MeSH:D013004
ERK5, also known as big MAP kinase 1 (BMK1), is twice the size of other MAPKs. The amino-terminal half contains the kinase domain, which is similar to that of ERK1/2 and has the TEY activation motif, whereas the carboxy-terminal half is unique. MEK5 phosphorylates and activates ERK5, and then the activated ERK5 phosphorylates substrates including myocyte enhancer factor 2 (MEF2).
BMK1
ERK5
ERK5, also known as big MAP kinase 1 (BMK1), is twice the size of other MAPKs. The amino-terminal half contains the kinase domain, which is similar to that of ERK1/2 and has the TEY activation motif, whereas the carboxy-terminal half is unique. MEK5 phosphorylates and activates ERK5, and then the activated ERK5 phosphorylates substrates including myocyte enhancer factor 2 (MEF2).
PMID:16880823
Apoptosis signal-regulating kinase 1
MAPK/ERK kinase kinase 5
MAPKKK5
MEK kinase 5
MEKK 5
apoptosis inducing kinase1
ASK1
TAO1
MAPKKK6
ASK2
MAPK/ERK kinase kinase 1
MEK kinase 1
MEKK1
MAP kinase kinase 5
MAPK/ERK kinase 5
MAPKK 5
MEK5
MKK5
MEK5(MKK5)
MLK7
MLTK
MRK
zipper sterile alpha motif kinase
ZAK
mixed lineage kinase
MLK
MAP3K9
MLK1
MAP3K10
MKN28 derived serine / threonine kinase
MST
MLK2
MAP3K11
PTK1
SH3 domain containing proline rich kinase
SPRK
protein tyrosine kinase 1
MLK3
MLK4
dual leucine zipper bearing kinase
DLK
Dual leucine zipper bearing kinase
Leucine-zipper protein kinase
MAP3K12
MAPK upstream kinase
MUK
ZPK
zipper protein kinase
DLK family
MAP3K13
leucine zipper kinase
LZK
SLP-76 family
MAP kinase-activated protein kinase 2
MAPK- activated protein kinase 2
MK2
MAPKAPK2
3PK
MAP kinase-activated protein kinase 3
MAPK- activated protein kinase 3
MAPKAPK3
GO:0005100
Rho GTPase-activating protein
Rho GAP
GO:0005097
Rab GTPase-activating protein
Rab GAP
GO:0008060
Arf GTPase-activating protein
Arf GAP
Four groups of kinases have been shown to be activated by MAP kinases, ribosomal S6 kinase (RSK also known as MAPKAPK1), MAP kinase-activated protein kinase 2/3 (MAPKAPK2/3), MAP kinase-interacting kinase or MAP kinase signal-integrating kinase (MNK) and MAPKAPK5 (PRAK).
MAP kinase-activated protein kinase
MAP kinase-regulated protein kinase
MAPK-activated protein kinase
MAPKAPK
Four groups of kinases have been shown to be activated by MAP kinases, ribosomal S6 kinase (RSK also known as MAPKAPK1), MAP kinase-activated protein kinase 2/3 (MAPKAPK2/3), MAP kinase-interacting kinase or MAP kinase signal-integrating kinase (MNK) and MAPKAPK5 (PRAK).
PMID:12639708
PMID:9628874
MAPKAPK5 (PRAK) activity is regulated by p38 and activated MAPKAPK5 in turn phosphorylates small heat shock protein 27 (HSP27).
MAP kinase-activated protein kinase 5
MAPK-activated protein kinase 5
PRAK
MAPKAPK5
MAPKAPK5 (PRAK) activity is regulated by p38 and activated MAPKAPK5 in turn phosphorylates small heat shock protein 27 (HSP27).
PMID:9628874
MNK1/2 are regulated by p38 and ERK, but not by JNK. MNK1/2 can phosphorylate eukaryotic initiation factor-4E (eIF-4E).
MAP kinase signal-integrating kinase
MAP kinase-interacting kinase
MNK
MNK1/2 are regulated by p38 and ERK, but not by JNK. MNK1/2 can phosphorylate eukaryotic initiation factor-4E (eIF-4E).
PMID:9628874
AR
SDGF
amphiregulin
BTC
betacellulin
EPR
epiregulin
heparin-binding EGF-like growth factor
HB-EGF
transforming growth factor alpha
TGF-alpha
GO:0005154 epidermal growth factor receptor binding
epidermal growth factor
EGF (mol)
IkB-alpha
inhibitor of NF-kappaB alpha
I-kappaB alpha
IkB-beta
inhibitor of NF-kappaB beta
I-kappaB beta
IkB-epsilon
inhibitor of NF-kappaB epsilon
I-kappaB epsilon
Bad (mol)
Bid (mol)
Bcl-2 interacting killer
Bik
BIM (mol)
A1
Bfl-1
Bcl-xL
caspase-6
caspase-7
caspase-9
caspase-8
caspase-10
NCBI-Human-GeneID:834
NCBI-Rat-GeneID:25166
caspase-1
NCBI-Human-GeneID:834
https://www.ncbi.nlm.nih.gov/gene/834
NCBI-Rat-GeneID:25166
https://www.ncbi.nlm.nih.gov/gene/25166
caspase-2 (mol)
caspase-4
caspase-5
caspase-11
caspase-12
caspase-14
caspase-13
Smad1
Smad2
Smad3
Smad5
Smad9
Smad8
Smad4
Smad6
Smad7
JAK1
JAK2
JAK3
Tyk2
CDw119
IFNG receptor alpha chain
IFNGR-1
IFNG receptor beta chain
accessory factor-1
IFNGR-2
neuronal apoptosis inhibitory protein
NAIP
HIAP2
MIHB
cellular inhibitor of apoptosis protein-1
mammalian IAP homologue B
c-IAP1
HIAP1
MIHC
cellular inhibitor of apoptosis protein-2
mammalian IAP homologue C
c-IAP2
IAP-like protein
ILP-1
MIHA
X-linked IAP
mammalian IAP homologue A
XIAP
Survivin
RasGRF1
RasGRF2
RasGRP
T-cell receptor alpha
TCR alpha
T-cell receptor beta
TCR beta
P59-FYN
SLK
SYN
Fyn
LSK
P56-LCK
T cell-specific protein-tyrosine kinase
Lck
c-Raf
c-Raf-1
Raf-1
PAK1
Cbl-b
Cbl-c
Cbl-3
G-alpha-s
G-alpha-olf
G-alpha-i 1
G-alpha-i 2
G-alpha-i 3
transducin alpha-1
G-alpha-t 1
transducin alpha-2
G-alpha-t 2
G-alpha-11
G-alpha-14
G-alpha-15
G-alpha-q
G-alpha-Y
G-alpha-12
G-alpha-13
Grb7/10/14 family
Cdk inhibitor protein
cyclin-dependent kinase inhibitor 1
p21
Cip1
cyclin-dependent kinase inhibitor p27
p27Kip1
cyclin-dependent kinase inhibitor p57
p57KIP2
Interferon alpha
IFN alpha
Interferon omega
IFN omega
Interferon beta
IFN beta
Interferon delta
IFN delta
Interferon gamma
IFN gamma
Interferon alpha/beta receptor-1
IFNAR-1
Interferon alpha/beta receptor-2
IFNAR-2
IMR:0010311
IMR:0011340
IMR:0011552
IRS1
insulin receptor substrate-1
IRS-1
IMR:0010312
IMR:0011553
IRS2
insulin receptor substrate-2
IRS-2
insulin receptor substrate-3
pp60
IRS-3
insulin receptor substrate-4
IRS-4
GO:0005163
nerve growth factor
NGF
brain-derived neurotrophic factor
BDNF
neurotrophic factor 3
neurotrophin-3
NT-3
NT-4
NT-5
neurotrophic factor 4
neurotrophic factor 5
neurotrophin-4
neurotrophin-5
NT-4/5
TR alpha 1
c-erbA-alpha 2
TR alpha 2
TR beta 1
TR beta 2
TNF receptor associated factor 1
TRAF1
TNF receptor associated factor 2
TRAF2 (mol)
TNF receptor associated factor 3
TRAF3 (mol)
TNF receptor associated factor 4
TRAF4
TNF receptor associated factor 5
TRAF5
TNF receptor associated factor 6
TRAF6
GAP1m
Ins P4-binding protein
GAP1(IP4BP)
Neurofibromatosis-related protein NF-1
Neurofibromin
NF-1
GAP
GTPase-activating protein
Ras p21 protein activator
p120GAP
RasGAP
RalGEF
RalGDS
GO:0005088
Ras guanine nucleotide exchange factor
RasGEF
p65
RelA
NF-kappaB1
NFKB1
p105
p50
IMR:0010357
ERK-1
ERT2
Extracellular signal-regulated kinase 1
Insulin-stimulated MAP2 kinase
MAP kinase 1
MAPK 1
Microtubule- associated protein-2 kinase
Mitogen-activated protein kinase 3
Mitogen-activated protein kinase 3 (EC 2.7.1.-) (Extracellular signal- regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein-2 kinase)
p44-ERK1
p44-MAPK
ERK1
Extracellular signal-regulated kinase 2
MAP kinase 2
MAPK 2
p42 MAPK
ERK2
MAPK/ERK kinase kinase 2
MEK kinase 2
MEKK2
MAPK/ERK kinase kinase 3
MEK kinase 3
MEKK3
ERK activator kinase 1
MAP kinase kinase 1
MAPK/ERK kinase 1
MAPKK 1
MEK1
MKK1
MEK1(MKK1)
ERK activator kinase 2
MAP kinase kinase 2
MAPK/ERK kinase 2
MAPKK 2
MEK2
MKK2
MEK2(MKK2)
JNK activating kinase 1
JNKK
JNKK 1
JNKK1
MAP kinase kinase 4
MKK4
SAPK/ERK kinase 1
SEK1
c- Jun N-terminal kinase kinase 1
MKK4(JNKK1)(SEK1)
JNK activating kinase 2
JNK kinase 2
JNKK 2
JNKK2
MAP kinase kinase 7
MAPK/ERK kinase 7
MAPKK 7
MKK7
SKK4
c-Jun N-terminal kinase kinase 2
MKK7(JNKK2)
MAP kinase kinase 3
MAPK/ERK kinase 3
MAPKK 3
MKK3
MAP kinase kinase 6
MAPK/ERK kinase 6
MAPKK 6
SAPKK3
MKK6
Inhibitor of nuclear factor kappa-B kinase alpha subunit
IKK alpha
Inhibitor of nuclear factor kappa B kinase beta subunit
IKK beta
NEMO
NF-kappaB essential modulator
IKK gamma
IKK epsilon
Fas-associated death domain
MORT1
mediator of receptor-induced toxicity
FADD
TNF receptor-associated death domain
TNFR-associated death domain
tumor necrosis factor receptor-associated death domain
TRADD (mol)
myeloid differentiation factor 88
MyD88
RAIDD
RIP-associated ICH-1/CED-3-homologous protein with a death domain
caspase and RIP adaptor with death domain
CRADD
SCF ubiquitin ligase complex is a subtype of molecular complex.
Skp1/Cul1/F-box protein complex
SCF ubiquitin ligase complex
protein kinase C theta
PKC theta
classical PKC isoforms (alpha, betaI, betaII and gamma) are regulated by calcium, diacylglycerol (DAG) and phospholipids.
conventional PKC
cPKC
classical PKC isoforms (alpha, betaI, betaII and gamma) are regulated by calcium, diacylglycerol (DAG) and phospholipids.
PMID:15282562
IL-1 receptor-associated kinase
Interleukin-1 receptor-associated kinase
Pelle-like protein kinase
IRAK
Smads 2 and 3 serve principally as substrates for the TGFbeta, activin, and Nodal receptors.
Smad2/3
Smads 2 and 3 serve principally as substrates for the TGFbeta, activin, and Nodal receptors.
PMID:16322555
Smads 1, 5, and 8 serve principally as substrates for the BMP and anti-Muellerian receptors.
Smad1/5/8
Smads 1, 5, and 8 serve principally as substrates for the BMP and anti-Muellerian receptors.
PMID:16322555
Smad ubiquitin regulatory factors
Smurf
E3 ubiquitin ligase
Smad-specific E3 ubiquitin ligase 1
Ubiquitin--protein ligase SMURF1
Ubiquitin-protein ligase
hSMURF1
xSMURF1
Smurf1
Smad-specific E3 ubiquitin ligase 2
Ubiquitin--protein ligase SMURF2
hSMURF2
Smurf2
GCK family
germinal center kinase
GCK
GCK related
KHS1
germinal center kinase related
GCKR
GCK-like kinase
GLK
Sequestosome 1
p62
GO:0004685
Ca2+/calmodulin-dependent protein kinase
CaM-kinase
CaMK
Ca2+/calmodulin-dependent protein kinase II
CaMKII
CaM-kinase II
PDGF A-chain
PDGF B-chain
AFGF
Acidic fibroblast growth factor
Beta-endothelial cell growth factor
ECGF-beta
HBGF-1
FGF-1
BFGF
Basic fibroblast growth factor
HBGF-2
Prostatropin
FGF-2
Fibroblast growth factor-3
HBGF-3
INT-2
FGF-3
HBGF-4
HST
HST-1
Heparin secretory transforming protein
K-fibroblast growth factor
KFGF
Transforming protein KS3
FGF-4
HBGF-5
Smag-82
FGF-5
HBGF-6
HST-2
FGF-6
Fibroblast growth factor-7
HBGF-7
KGF
FGF-7
AIGF
Fibroblast growth factor-8
HBGF-8
FGF-8
Fibroblast growth factor-9
GAF
HBGF-9
FGF-9
Keratinocyte growth factor 2
FGF-10
FHF-3
Fibroblast growth factor homologous factor 3
FGF-11
FHF-1
Fibroblast growth factor homologous factor 1
Myocyte-activating factor
FGF-12
FHF-2
Fibroblast growth factor homologous factor 2
FGF-13
FHF-4
Fibroblast growth factor homologous factor 4
FGF-14
FGF-15
FGF-16
FGF-17
zFGF5
FGF-18
FGF-19
FGF-20
FGF-21
FGF-22
Tumor-derived hypophosphatemia inducing factor
FGF-23
NCBI-Human-GeneID:6714
NCBI-Mouse-GeneID:20779
NCBI-Rat-GeneID:83805
c-Src
p60-Src
Src (mol)
NCBI-Human-GeneID:6714
https://www.ncbi.nlm.nih.gov/gene/6714
NCBI-Mouse-GeneID:20779
https://www.ncbi.nlm.nih.gov/gene/20779
NCBI-Rat-GeneID:83805
https://www.ncbi.nlm.nih.gov/gene/83805
transmembrane heparan sulfate proteoglycan
syndecan
CD138 antigen
SYND1
syndecan-1
HSPG
Heparan sulfate proteoglycan core protein
SYND2
fibroglycan
syndecan-2
N-syndecan
Neuroglycan
SYND3
syndecan-3
Amphiglycan
Ryudocan core protein
SYND4
syndecan-4
IMR:0010392
PI3K
Phosphatidylinositol 3-kinase regulatory alpha subunit
PtdIns-3-kinase p85-alpha
PI3-kinase p85-alpha subunit
IMR:0010393
Phosphatidylinositol 3-kinase regulatory beta subunit
PtdIns-3-kinase p85-beta
PI3-kinase p85-beta subunit
IMR:0010389
PI3K
Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform (EC 2.7.1.137) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
PtdIns-3-kinase p110
PI3-kinase p110 subunit alpha
IMR:0010390
PI3K
PI3Kbeta
Phosphatidylinositol 3-kinase catalytic subunit, beta isoform (EC 2.7.1.137) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, beta isoform
PtdIns-3-kinase p110
PI3-kinase p110 subunit beta
PI3K
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform
PtdIns-3-kinase p110
p110delta
PI3-kinase p110 subunit delta
IMR:0010763
CDC28
CDK1
Cdc2
Cell division control protein 2 homolog
Cell division control protein 2 homolog (EC 2.7.1.-) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1)
Cell division control protein 2 homolog (EC 2.7.1.-) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) form
Cyclin-dependent kinase 1
p34 protein kinase
Cdc2 (mol)
IMR:0010671
Cdk2
Cell division protein kinase 2
Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2)
cyclin-dependent kinase 2
p33 protein kinase
CDK2 (mol)
Cell division protein kinase 3
CDK3(mol)
CRK6
Cell division protein kinase 5
Serine/threonine protein kinase PSSALRE
TPKII catalytic subunit
Tau protein kinase II catalytic subunit
CDK5(mol)
IMR:0010667
CRK2
Cdk6
Cell division protein kinase 6
Cell division protein kinase 6 (EC 2.7.1.-)(Serine/threonine-protein kinase) (PLSTIRE)(CDK6)
Serine/threonine protein kinase PLSTIRE
CDK6(mol)
IMR:0010771
39 kDa protein kinase
39 protein kinase
CAK
CAK1
CDK-activating kinase
CR4 protein kinase
Cdk7
Cell division protein kinase 7
Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1)
P39 Mo15
Protein-tyrosine kinase MPK-7
STK1
TFIIH basal transcription factor complex kinase subunit
CDK7(mol)
Cell division protein kinase 8
Protein kinase K35
CDK8(mol)
IMR:0010181
C-2K
Cdk 9 protein
Cell division protein kinase 9
Serine/threonine-protein kinase PITALRE
CDK9(mol)
cyclin
cyclin A
IMR:0010764
IMR:0011589
CGA1
Cyclin A1
cyclin A1
IMR:0010768
IMR:0011591
CGA2
Cyclin A
Cyclin A2
cyclin A
cyclin A2
cyclin B
IMR:0010767
IMR:0011592
CGB1
G2/mitotic-specific cyclin B1
cyclin B1
IMR:0010766
IMR:0011593
CGB2
G2/mitotic-specific cyclin B2
cyclin B2
cyclin C
cyclin D
IMR:0010664
IMR:0011612
BCL-1 oncogene
CGD1
G1/S-specific cyclin D1
PRAD1 oncogene
cyclin D1
IMR:0010668
IMR:0011614
CGD2
G1/S-specific cyclin D2
Vin-1 proto-oncogene
cyclin D2
IMR:0010666
IMR:0011615
CGD3
G1/S-specific cyclin D3
cyclin D3
cyclin E
IMR:0010670
IMR:0011462
CGE1
G1/S-specific cyclin E1
cyclin E1
IMR:0010672
IMR:0011595
CGE2
G1/S-Specific cyclin E2
cyclin E2
G2/mitotic-specific cyclin F
cyclin F
cyclin G
cyclin G
cyclin G1
cyclin G2
IMR:0010772
IMR:0011707
CYCH
Cyclin H
MO15-associated protein
p34
p37
cyclin H
cyclin I
cyclin K
cyclin T
IMR:0010177
IMR:0011619
CCT1
CycT1
Cyclin T
Cyclin T1
cyclin T
cyclin T1
IMR:0010178
Cyclin T2
cyclin T2
CDK-activating kinase
CAK
CDK inhibitor p40
SIC1 protein
Sic1
Caspase-like protein ESPL1
Cut1
Esp1
Extra spindle poles-like 1 protein
separin
separase
IMR:0010777
IMR:0011713
http://purl.obolibrary.org/obo/PR_000003035
Antigen NY-CO-13
Cellular tumor antigen p53
P53
Phosphoprotein p53
Tumor suppressor p53
p53 protein
p53 (mol)
IMR:0010776
Double minute 2 protein
Hdm2
Oncoprotein Mdm2
Ubiquitin-protein ligase E3 Mdm2
Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2)
p53-binding protein Mdm2
Mdm2 (mol)
G1/S-specific cyclin CLN1
Cln1
G1/S-specific cyclin CLN2
Cln2
G1/S-specific cyclin CLN3
Cln3
G2/mitotic-specific cyclin 1
Clb1
G2/mitotic-specific cyclin 2
Clb2
G2/mitotic-specific cyclin 3
Clb3
G2/mitotic-specific cyclin 4
Clb4
S-phase entry cyclin 5
Clb5
S-phase entry cyclin 6
Clb6
G1-cyclin
G1/S-cyclin
S-cyclin
G2/M-cyclin
M-cyclin
TNF alpha receptor
CD221 antigen
Insulin-like growth factor I receptor precursor
IGF-1 receptor
IMR:0200368
1D-myo-Inositol 1,4-bisphosphate
D-myo-Inositol 1,4-bisphosphate
Inositol 1,4-bisphosphate
myo-Inositol 1,4-bisphosphate
IP2
EC:3.1.4.17
GO:0004115
cAMP-specific PDE
cAMP-specific phosphodiesterase
cyclic AMP phosphodiesterase
cAMP phosphodiesterase
EC:3.1.3.67
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
PTEN
GO:0008603
cAMP-dependent protein kinase regulatory chain
PKA regulatory subunit
GO:0004691
cAMP-dependent protein kinase catalytic subunit
PKA catalytic subunit
Prothrombin
thrombin
pro-survival Bcl-2 family
anti-apoptotic Bcl-2 family
Bcl-2 subfamily
pro-apoptotic Bcl-2 family
Bax subfamily
Bik family
BH3 subfamily
IMR:0010562
40S ribosomal subunit protein S6
40S small ribosomal protein 6
40S ribosomal protein S6
IPR:008297
N
Notch
NCBI-Human-GeneID:4851
NCBI-Mouse-GeneID:18128
NCBI-Rat-GeneID:25496
Notch-1
Notch1
Notch 1 (mol)
NCBI-Human-GeneID:4851
https://www.ncbi.nlm.nih.gov/gene/4851
NCBI-Mouse-GeneID:18128
https://www.ncbi.nlm.nih.gov/gene/18128
NCBI-Rat-GeneID:25496
https://www.ncbi.nlm.nih.gov/gene/25496
NCBI-Human-GeneID:4853
NCBI-Mouse-GeneID:18129
NCBI-Rat-GeneID:29492
Notch-2
Notch2
Notch 2 (mol)
NCBI-Human-GeneID:4853
https://www.ncbi.nlm.nih.gov/gene/4853
NCBI-Mouse-GeneID:18129
https://www.ncbi.nlm.nih.gov/gene/18129
NCBI-Rat-GeneID:29492
https://www.ncbi.nlm.nih.gov/gene/29492
NCBI-Human-GeneID:4854
NCBI-Mouse-GeneID:18131
NCBI-Rat-GeneID:56761
Neurogenic locus notch homolog protein 3 precursor
Notch-3
Notch3
Notch 3 (mol)
NCBI-Human-GeneID:4854
https://www.ncbi.nlm.nih.gov/gene/4854
NCBI-Mouse-GeneID:18131
https://www.ncbi.nlm.nih.gov/gene/18131
NCBI-Rat-GeneID:56761
https://www.ncbi.nlm.nih.gov/gene/56761
Notch-4
Notch4
Notch 4
Delta
DLL1
Delta1
Delta-like1
DLL3
Delta-like3
DLL4
Delta4
Delta-like4
PS-1
S182 protein
presenilin 1
AD3LP
AD5
ALG-3
Alzheimer disease 4 homolog
E5-1
PS-2
STM-2
presenilin 2
STAT5
GSK-3 alpha
NCBI-Human-GeneID:50846
NCBI-Mouse-GeneID:13363
NCBI-Rat-GeneID:84380
Desert hedgehog
HHG-3
DHH (mol)
NCBI-Human-GeneID:50846
https://www.ncbi.nlm.nih.gov/gene/50846
NCBI-Mouse-GeneID:13363
https://www.ncbi.nlm.nih.gov/gene/13363
NCBI-Rat-GeneID:84380
https://www.ncbi.nlm.nih.gov/gene/84380
NCBI-Human-GeneID:3549
NCBI-Mouse-GeneID:16147
NCBI-Rat-GeneID:84399
HHG-2
Indian hedgehog
IHH (mol)
NCBI-Human-GeneID:3549
https://www.ncbi.nlm.nih.gov/gene/3549
NCBI-Mouse-GeneID:16147
https://www.ncbi.nlm.nih.gov/gene/16147
NCBI-Rat-GeneID:84399
https://www.ncbi.nlm.nih.gov/gene/84399
T cell-specific transcription factor 1-alpha
TCF1-alpha
LEF-1
T-cell factor 1
T-cell-specific transcription factor 1
TCF-1
TCF7
Transcription factor 7
TCF-1
HMG-box transcription factor 3
TCF-3
TCF7L1
Transcription factor 7-like 1
mTCF-3
TCF-3
HMG box transcription factor 4
T-cell-specific transcription factor 4
TCF-4
TCF7L2
hTCF-4
mTCF-4
TCF-4
IPR:008339
dishevelled family
Dsh family
DSH homolog 1
Dishevelled-1
Dvl-1
DSH homolog 2
Dishevelled-2
Dvl-2
DSH homolog 3
Dishevelled-3
Dvl-3
DSH homolog 1-like
Dishevelled-1-like
Dvl-1-like
Int-1
Wnt-1
IRP protein
Int-1 related protein
Wnt-2
Wnt-13
Wnt-2b
Wnt-3
Wnt-3a
Wnt-4
Wnt-5a
Wnt-5b
Wnt-6
Wnt-7a
Wnt-7b
Wnt-8d
Wnt-8a
Wnt-8b
Wnt-14
Wnt-9a
Wnt-14b
Wnt-15
Wnt-9b
Wnt-10a
Wnt-12
Wnt-10b
Wnt-11
Wnt-16
LDL receptor-related protein
low density lipoprotein receptor-related protein
low-density lipoprotein receptor-related protein
LRP family
LDL receptor-related protein 1
low density lipoprotein receptor-related protein 1
low-density lipoprotein receptor-related protein 1
LRP1
Glycoprotein 330
LDL-receptor-related protein 2
Megalin
gp330
low density lipoprotein (LDL) receptor-related protein 2
LRP2
GO:0004681
Casein kinase I
CK1
Casein kinase I, alpha isoform
CKI-alpha
Casein kinase I, gamma 1 isoform
CKI-gamma 1
Casein kinase I, gamma 2 isoform
CKI-gamma 2
Casein kinase I, gamma 3 isoform
CKI-gamma 3
CKId
Casein kinase I, delta isoform
CKI-delta
CKIe
Casein kinase I, epsilon isoform
CKI-epsilon
JAB
JAK-binding protein
SSI-1
STAT induced STAT inhibitor 1
Suppressor of cytokine signaling 1
TIP-3
Tec-interacting protein 3
SOCS-1
CIS-2
Cytokine-inducible SH2 protein 2
SSI-2
STAT induced STAT inhibitor 2
Suppressor of cytokine signaling 2
SOCS-2
CIS-3
Cytokine-inducible SH2 protein 3
Protein EF-10
SSI-3
STAT induced STAT inhibitor 3
Suppressor of cytokine signaling 3
SOCS-3
CIS-4
Cytokine-inducible SH2 protein 4
Suppressor of cytokine signaling 4
SOCS-4
CIS-6
Cytokine-inducible SH2 protein 6
Suppressor of cytokine signaling 5
SOCS-5
NAP-4
Nck, Ash and phospholipase C gamma-binding protein
Nck-associated protein 4
Suppressor of cytokine signaling 6
SOCS-6
Suppressor of cytokine signaling 7
SOCS-7
C-AKT
PKB alpha
RAC-PK-alpha
RAC-alpha serine/threonine protein kinase
protein kinase B alpha
Akt1 (mol)
PKB beta
RAC-PK-beta
RAC-beta serine/threonine protein kinase
protein kinase B beta
Akt2 (mol)
PKB gamma
RAC-PK-gamma
RAC-gamma serine/threonine protein kinase
STK-2
protein kinase B gamma
Akt3
TSE1
Tissue-specific extinguisher-1
cAMP-dependent protein kinase type I-alpha regulatory chain
PKA type I alpha regulatory subunit
cAMP-dependent protein kinase type I-beta regulatory chain
PKA type I beta regulatory subunit
cAMP-dependent protein kinase type II-alpha regulatory chain
PKA type II alpha regulatory subunit
cAMP-dependent protein kinase type II-beta regulatory chain
PKA type II beta regulatory subunit
PKA C-alpha
cAMP-dependent protein kinase, alpha-catalytic subunit
PKA alpha catalytic subunit
PKA C-beta
cAMP-dependent protein kinase, beta-catalytic subunit
PKA beta catalytic subunit
PKA C-gamma
cAMP-dependent protein kinase, gamma-catalytic subunit
PKA gamma catalytic subunit
Interleukin-1 alpha
IL-1 alpha
Interleukin-1 beta
IL-1 beta
Prostaglandin F2
L-Asparagine
L-Histidine
L-Lysine
Prostaglandin E2
L-Threonine
L-Proline
L-Tyrosine
L-Alanine
Prostaglandin H2
L-Isoleucine
L-Phenylalanine
Prostaglandin I2
L-Dopa
GMP
L-Tryptophan
L-Ornithine
L-Arginine
L-Glutamine
L-Serine
Prostaglandin D2
L-Aspartic acid
L-Cysteine
L-Methionine
L-Leucine
Prostaglandin G2
L-Valine
reduced oxygenation of body tissues resulting in the decreased pressure of this component of body gases; commonly due to hypoxemia
decreased tissue partial O2 level
hypoxia
house mouse
mouse
mus musculus
rat
rats
rattus
PMID:23020233
eucaryotes
eukaryotes
Eukaryota
http://purl.bioontology.org/ontology/STY/T015
mammal
mammals
mammalia
Vertebrata
vertebrates
vertebrate
http://purl.bioontology.org/ontology/STY/T016
human
homo sapiens
rodent
rodentia
A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04)
BSO
Buthionine sulfoximine
A family of transmembrane proteins that play a role in the transport of organic anions including bile acids and bilirubin.
OATP
SLCO
Solute Carrier Organic Anion
OATP family
Non-neoplastic macrophages that are found in close proximity to or within a tumor mass. [ NCI ]
CD163-positive cells
TAM
tumor-associated macrophage
A laboratory test or analysis of the biological activity of a substance performed by studying its effect in an experimental situation outside the organism, e.g. in the test tube rather than in living systems.
in vitro assay
A laboratory test or analysis of the biological activity of a substance performed by studying its effect in an experimental situation outside the organism, e.g. in the test tube rather than in living systems.
https://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C1511123
http://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=200906081082476489
http://purl.bioontology.org/ontology/MESH/D002470
cell survival
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
MeSH:D004249
http://purl.obolibrary.org/obo/NCIT_C16507
DNA damage
A chemical reaction that uses water to break down a compound.
hydrolysis
A pathological process in which normal cells are transformed into malignant cancer cells within a primary tumor.
http://purl.obolibrary.org/obo/NCIT_C18078
ncit:C18078
Carcinogenesis
carcinogenesis
A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation.
A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation.
http://purl.obolibrary.org/obo/NCIT_C18121
ncit:C18121
Oncogenesis
tumorigenesis
The spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor.
metastasis
The processes which result in cancers in the liver.
http://purl.obolibrary.org/obo/NCIT_C19427
ncit:C19427
liver carcinogenesis
hepatocarcinogenesis
Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response. (NCI)
http://purl.obolibrary.org/obo/NCIT_C20613
clonal expansion
Organic Cation Transporter proteins carry positively charged chemical substances containing covalently bound carbon atoms through solubility barriers, such as lipid membranes or across epithelial layers. After binding substrate, transmembrane transporters often undergo an energy-dependent conformational change that moves the substrate across the membrane with (symport) or against (antiport) concentration gradients.
OCT family
Organic Cation Transport Protein
Organic Cation Transporter
A usually exophytic mass attached to the underlying tissue by a broad base or a thin stalk. Polyps can be neoplastic or non-neoplastic. Neoplastic polyps usually represent proliferations of the epithelium, and are commonly seen in the gastrointestinal tract. Polyps of the gastrointestinal tract are often called adenomas, are associated with dysplasia, and may eventually transform into carcinomas. Non-neoplastic polyps may be inflammatory, degenerative, or the result of malformations.
polyp
The level of degree is high in comparison to medium.
high level
Obstruction or a closure of hollow organ, passageway or vessel; also the transient approximation of the edges of a natural opening; imperforation.
The act of closure or the state of being closed; an obstruction; the relationship between all of the components of the masticatory system in normal function, dysfunction, and parafunction; momentary complete closure of some area in the vocal tract, causing stoppage of the breath and accumulation of pressure.
http://purl.obolibrary.org/obo/NCIT_C50678
occlusion
A set or series of interactions, often forming a network, which biologists have found useful to group together for organizational, historic, biophysical, or other reasons.
pathway
a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body.
OBI, CDISC
Regulatory agency, Ethics committee, Approval letter; example: Browse these EPA Regulatory Role subtopics http://www.epa.gov/ebtpages/enviregulatoryrole.html Feb 29, 2008
govt agents responsible for creating regulations; proxies for enforcing regulations. CDISC definition: regulatory authorities. Bodies having the power to regulate. NOTE: In the ICH GCP guideline the term includes the authorities that review submitted clinical data and those that conduct inspections. These bodies are sometimes referred to as competent
regulatory role
A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.
scientific observation
assay
a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider
OBI, CDISC
CDISC definition: patient. Person under a physician's care for a particular disease or condition. NOTE: A subject in a clinical trial is not necessarily a patient, but a patient in a clinical trial is a subject. See also subject, trial subject, healthy volunteer. Often used interchangeably
patient role
An imaging assay is an assay to produce a picture of an entity.
imaging assay
pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role
OBI
pathogen role
An imaging assay in which an electrons are used to probe the density, shape and composition of an input material which are detected in an electron microscope and utilized to produce an image of the material.
electron microscopy imaging assay
secondary cultured cell
A cultured cell that has been passaged or derives from a cell that has been passaged in culture.
The term 'secondary cell culture' is generally used in biological texts/protocols to refer to any culture following an initial passage. We include it here because there are often a number of passages between a primary culture and the establishment of a stable, homogenous cell line. Such cultures are considered to be 'secondary cultures' but not 'cell lines' during this intermediate passaging/selection period between their derivation from a 'primary cell culture' and derivation into a 'cell line', which is a more specific type of secondary culture.
Person: Matthew Brush
A secondary cultured cell has been passaged in culture or is a descendant of such a cell that is derived through propagation in culture.
secondary cultured cell
An organism is material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
http://purl.obolibrary.org/obo/obi.owl
Its function is to do life activity.
organism
A data item that was generated on the basis of a calculation or logical reasoning
predicted data item
occurrence of infectious disease
Is an occurrence of a disease caused by an infection
IEDB
IEDB
occurrence of infectious disease
occurrence of allergy
The process of an allergic disease occurring in an organism.
IEDB
IEDB
occurrence of allergy
A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule.
Physical and functional unit of heredity, which carries information from one generation to the next. In molecular terms, it is the entire DNA sequence including exons, introns, and noncoding transcription-control regions necessary for production of a functional protein or RNA.
gene
A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule.
http://www.ncbi.nlm.nih.gov/books/NBK21640/
Physical and functional unit of heredity, which carries information from one generation to the next. In molecular terms, it is the entire DNA sequence including exons, introns, and noncoding transcription-control regions necessary for production of a functional protein or RNA.
ISBN:9780716737063
A gene of an organism of Eukaryota
Yue Liu, Bin Zhao, Oliver He
2759
gene of Eukaryota
A gene of an organism of Homo sapiens
Yue Liu, Bin Zhao, Oliver He
9606
gene of Homo sapiens
A gene of Homo sapiens that has a protein-coding gene disposition
Bin Zhao, Oliver He
9606
protein-coding gene of Homo sapiens
A gene of Homo sapiens that has a pseudo gene disposition
Bin Zhao, Oliver He
9606
pseudo gene of Homo sapiens
A gene of Homo sapiens that has a ncRNA gene disposition
Bin Zhao, Oliver He
9606
ncRNA gene of Homo sapiens
A gene of Homo sapiens that has a RNA gene disposition
Bin Zhao, Oliver He
9606
RNA gene of Homo sapiens
Bin Zhao, Yue Liu, Oliver He
AACT
ACT
GIG25
WEB: http://www.ncbi.nlm.nih.gov/gene
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
12
GIG24
14q32.1
9606
14
Official from a nomenclature committee
GO_0003677 (EC: TAS, PMID: 14668352); GO_0004867 (EC: IBA); GO_0004867 (EC: TAS, PMID: 2404007); GO_0005515 (EC: IPI, PMID: 12709365); GO_0005576 (EC: IBA); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005622 (EC: NAS, PMID: 9880565); GO_0005634 (EC: TAS, PMID: 14668352); GO_0006953 (EC: IEA); GO_0006954 (EC: NAS, PMID: 12475184); GO_0010951 (EC: IBA); GO_0019216 (EC: NAS, PMID: 11835318); GO_0030162 (EC: IBA); GO_0030277 (EC: NAS, PMID: 8647626); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072562 (EC: IDA)
PMID: 123121; 1311327; 1351206; 1618300; 2016749; 2190106; 2404007; 2432851; 2435303; 2456771; 2787670; 2945424; 3028924; 3257719; 3260956; 3485824; 3490907; 3492865; 3637050; 6547997; 6556193; 6606438; 6687683; 6762318; 7521171; 7528097; 7588564; 7759598; 7873202; 7924407; 7966721; 8011628; 8216224; 8226889; 8244391; 8267879; 8365378; 8376411; 8647626; 8718849; 8732755; 8739078; 8836107; 8849841; 9042371; 9261179; 9428387; 9521649; 9580375; 9635374; 9698370; 9824262; 9880565; 10048303; 10209959; 10228625; 10512690; 10618372; 10660528; 10759471; 10829039; 11096092; 11099722; 11132933; 11161981; 11274154; 11289720; 11290389; 11295654; 11317942; 11385264; 11692021; 11735417; 11769703; 11798857; 11835318; 11916200; 11936240; 11959399; 11992569; 12023832; 12126519; 12324297; 12475184; 12477932; 12600202; 12685871; 12709365; 12736093; 12754519; 12782964; 14668352; 14687906; 14702039; 14718574; 14760718; 15014966; 15131125; 15159602; 15482730; 15489334; 15530656; 15542006; 15546506; 15612581; 15638460; 15653173; 15659365; 15718509; 15907346; 15935385; 16099106; 16137793; 16278826; 16303762; 16335952; 16424370; 16453284; 16565071; 16712791; 16892178; 16968986; 17207965; 17608807; 17690329; 17854420; 18056971; 18078695; 18248459; 18383875; 18401426; 18408372; 18842294; 18991685; 19008959; 19056867; 19165527; 19247692; 19341158; 19390575; 19525388; 19578796; 19590686; 19789190; 19907165; 19913121; 19933216; 19959196; 20117085; 20158662; 20302328; 20378355; 20444200; 20628086; 21067581; 21296644; 21674799; 21693707; 21730889; 21988832; 22079093; 22246292; 22272609; 22294107; 22806587; 22869038; 23669352; 24172014
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Ensembl:ENSG00000196136
HGNC:16
HPRD:00120
MIM:107280
Vega:OTTHUMG00000029851
Other designations: alpha-1-antichymotrypsin|cell growth-inhibiting gene 24/25 protein|growth-inhibiting protein 24|growth-inhibiting protein 25|serine (or cysteine) proteinase inhibitor, clade A, member 3|serpin A3
SERPINA3
Bin Zhao, Yue Liu, Oliver He
ACAC
ACACAD
ACC
ACC1
ACCA
WEB: http://www.ncbi.nlm.nih.gov/gene
ACACA
acetyl-CoA carboxylase alpha
31
17q21
9606
17
Official from a nomenclature committee
GO_0001894 (EC: IEA); GO_0003989 (EC: ISS); GO_0003989 (EC: TAS); GO_0004075 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16326698); GO_0005524 (EC: IEA); GO_0005739 (EC: IEA); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006084 (EC: ISS); GO_0006112 (EC: TAS); GO_0006633 (EC: ISS); GO_0006766 (EC: TAS); GO_0006767 (EC: TAS); GO_0006768 (EC: TAS); GO_0006853 (EC: TAS); GO_0019432 (EC: TAS); GO_0031325 (EC: TAS); GO_0035338 (EC: TAS); GO_0044255 (EC: TAS); GO_0044268 (EC: IEA); GO_0044281 (EC: TAS); GO_0046872 (EC: IEA); GO_0051289 (EC: ISS); GO_0055088 (EC: IEA); GO_2001295 (EC: IEA)
PMID: 2900138; 2900140; 2906852; 7732023; 7905825; 7907095; 7915280; 8944226; 10677481; 10737800; 11052978; 12360400; 12477932; 12810950; 14643797; 15302935; 15333468; 15607423; 16169070; 16326698; 16698035; 16713569; 16794074; 16806233; 17081983; 17372234; 17521700; 17620599; 17631500; 18031993; 18056116; 18303054; 18452305; 18455495; 18487259; 18614941; 18614968; 18660489; 18678647; 18996102; 19061860; 19343720; 19380743; 19543203; 19710915; 19720090; 19723093; 19738201; 19842072; 19846279; 19913121; 20139635; 20379614; 20431927; 20457939; 20562859; 20602615; 20628086; 20877624; 20965718; 21139048; 21344388; 21471234; 21638027; 21642987; 21726077; 21890473; 21906983; 22238651; 22268729; 22505724; 22586326; 22863883; 22939629; 23000302; 23181366; 23383273; 23455922; 23535730; 23886516; 24457600
acetyl-CoA carboxylase alpha
Ensembl:ENSG00000132142
HGNC:84
HPRD:01938
MIM:200350
Vega:OTTHUMG00000133064
Other designations: ACC-alpha|acetyl-CoA carboxylase 1|acetyl-Coenzyme A carboxylase alpha
ACACA
Bin Zhao, Yue Liu, Oliver He
ACC2
ACCB
HACC275
WEB: http://www.ncbi.nlm.nih.gov/gene
ACACB
acetyl-CoA carboxylase beta
32
12q24.11
9606
12
Official from a nomenclature committee
GO_0003989 (EC: IDA); GO_0004075 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16794074); GO_0005524 (EC: IEA); GO_0005741 (EC: TAS); GO_0005829 (EC: TAS); GO_0006084 (EC: IDA); GO_0006112 (EC: TAS); GO_0006633 (EC: IEA); GO_0006766 (EC: TAS); GO_0006767 (EC: TAS); GO_0006768 (EC: TAS); GO_0006853 (EC: TAS); GO_0009374 (EC: IEA); GO_0012505 (EC: IEA); GO_0014070 (EC: IEA); GO_0031325 (EC: TAS); GO_0042493 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0046872 (EC: IEA); GO_0051289 (EC: IDA); GO_2001295 (EC: IEA)
PMID: 8670171; 8876158; 9099716; 9148944; 9284908; 10677481; 11257506; 12086953; 12413941; 12477932; 14532170; 14613924; 14627750; 15060529; 15590647; 16054041; 16794074; 16854592; 17223360; 17521700; 18029348; 18031993; 18455495; 18976975; 18996102; 19034549; 19190759; 19322201; 19390150; 19618481; 19720090; 19846279; 19900410; 20085763; 20139635; 20168990; 20379614; 20468064; 20514549; 20519229; 20599696; 20602615; 20799892; 20855566; 20877624; 20965718; 21139048; 21344388; 21553357; 21887335; 21906983; 21908218; 21953464; 23081748; 23156397; 23455922; 23460794; 24255178
acetyl-CoA carboxylase beta
Ensembl:ENSG00000076555
HGNC:85
HPRD:07044
MIM:601557
Vega:OTTHUMG00000169250
Other designations: ACC-beta|acetyl-CoA carboxylase 2|acetyl-Coenzyme A carboxylase beta
ACACB
Bin Zhao, Yue Liu, Oliver He
ACOX
PALMCOX
SCOX
WEB: http://www.ncbi.nlm.nih.gov/gene
ACOX1
acyl-CoA oxidase 1, palmitoyl
51
17q25.1
9606
17
GO_0000038 (EC: IMP, PMID:18536048); GO_0003995 (EC: IEA); GO_0003997 (EC: IDA, PMID:8117268); GO_0003997 (EC: IGI, PMID:17458872); GO_0003997 (EC: IMP, PMID:18536048); GO_0003997 (EC: TAS); GO_0005102 (EC: IPI); GO_0005504 (EC: IEA); GO_0005739 (EC: IEA); GO_0005777 (EC: IDA, PMID:17881773); GO_0005778 (EC: IEA); GO_0005782 (EC: TAS); GO_0006091 (EC: IMP, PMID:7876265); GO_0006629 (EC: IDA, PMID:8117268); GO_0006693 (EC: IMP, PMID:7876265); GO_0007283 (EC: IEA); GO_0016401 (EC: IDA, PMID:17603022); GO_0016401 (EC: IEA); GO_0016559 (EC: IGI); GO_0019395 (EC: IGI); GO_0019395 (EC: IMP, PMID:7876265); GO_0030165 (EC: IDA); GO_0033540 (EC: IEA); GO_0033540 (EC: IMP, PMID:18536048); GO_0033540 (EC: TAS); GO_0033559 (EC: TAS); GO_0036109 (EC: TAS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0047485 (EC: IPI, PMID:18281296); GO_0050660 (EC: IEA); GO_0055088 (EC: IDA); GO_0055088 (EC: IGI); GO_0071949 (EC: IDA, PMID:17603022); GO_2000189 (EC: IGI)
PMID:1464743; 7668838; 7876265; 8040306; 8117268; 8125298; 8159712; 8507686; 8798738; 10856712; 10960480; 11076863; 11230166; 11815777; 12477932; 14702039; 15489334; 15489336; 16381901; 16396496; 16756494; 17081983; 17458872; 17603022; 17881773; 18281296; 18536048; 18660489; 20178365; 20195242; 21139048; 22002062; 22939629
acyl-CoA oxidase 1, palmitoyl
Ensembl:ENSG00000161533
HGNC:119
HPRD:02030
MIM:609751
Vega:OTTHUMG00000180027
Other designations: AOX|acyl-CoA oxidase, straight-chain|acyl-Coenzyme A oxidase 1, palmitoyl|palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-CoA oxidase|straight-chain acyl-CoA oxidase
ACOX1
Bin Zhao, Yue Liu, Oliver He
CD156
CD156a
MS2
WEB: http://www.ncbi.nlm.nih.gov/gene
ADAM8
ADAM metallopeptidase domain 8
101
10q26.3
9606
10
Official from a nomenclature committee
GO_0000902 (EC: ISS); GO_0001525 (EC: ISS); GO_0002102 (EC: IDA, PMID: 15220135); GO_0002523 (EC: ISS); GO_0002675 (EC: ISS); GO_0004222 (EC: IEA); GO_0005509 (EC: ISS); GO_0005515 (EC: IPI, PMID: 12777399); GO_0005737 (EC: IDA, PMID: 18397961); GO_0005886 (EC: IDA, PMID: 17548643); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 18397961); GO_0006954 (EC: IDA, PMID: 17548643); GO_0008237 (EC: IDA, PMID: 12777399); GO_0008270 (EC: TAS, PMID: 18397961); GO_0009986 (EC: IDA, PMID: 17548643); GO_0010954 (EC: NAS, PMID: 17548643); GO_0016337 (EC: IEA); GO_0022407 (EC: IDA, PMID: 17548643); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0032010 (EC: IDA, PMID: 17548643); GO_0032127 (EC: IDA, PMID: 17548643); GO_0033089 (EC: ISS); GO_0035419 (EC: ISS); GO_0042581 (EC: IDA, PMID: 17548643); GO_0043524 (EC: ISS); GO_0043621 (EC: TAS, PMID: 12777399); GO_0045780 (EC: ISS); GO_0045785 (EC: ISS); GO_0048247 (EC: ISS); GO_0050714 (EC: IC, PMID: 17548643); GO_0050839 (EC: IPI, PMID: 12777399); GO_0051044 (EC: IDA, PMID: 15220135); GO_0051092 (EC: ISS); GO_0051897 (EC: ISS); GO_0070245 (EC: ISS); GO_0070820 (EC: IDA, PMID: 17548643); GO_0071065 (EC: IDA, Qualifier: colocalizes_with, PMID: 15220135); GO_0071133 (EC: ISS); GO_0071456 (EC: IDA, PMID: 18566576); GO_2000309 (EC: ISS); GO_2000391 (EC: IDA, PMID: 17548643); GO_2000415 (EC: ISS); GO_2000418 (EC: ISS)
PMID: 9126482; 10354553; 12135759; 12477932; 12777399; 15220135; 15574124; 15623614; 16344560; 16385451; 17339047; 17548643; 17979891; 18397961; 18566576; 18682798; 18691140; 18710625; 18811590; 19284887; 19397475; 19469654; 19575316; 19601829; 19714641; 19766586; 20453887; 20628624; 21077325; 21640993; 21679521; 21728902; 21983884; 22215309; 22229154; 22878099; 22941466; 22959284; 22965687; 23670189
ADAM metallopeptidase domain 8
Ensembl:ENSG00000151651
HGNC:215
HPRD:03777
MIM:602267
Vega:OTTHUMG00000019309
Other designations: a disintegrin and metalloproteinase domain 8|cell surface antigen MS2|disintegrin and metalloproteinase domain-containing protein 8|human leukocyte differentiation antigen
ADAM8
Bin Zhao, Yue Liu, Oliver He
ADFP
ADRP
WEB: http://www.ncbi.nlm.nih.gov/gene
PLIN2
perilipin 2
123
RP11-151J10.1
9p22.1
9606
9
Official from a nomenclature committee
GO_0005576 (EC: TAS, PMID: 9003395); GO_0005634 (EC: IEA); GO_0005783 (EC: TAS, PMID: 9003395); GO_0005811 (EC: IDA, PMID: 14741744); GO_0005886 (EC: TAS); GO_0014070 (EC: IEA); GO_0015909 (EC: IEA); GO_0019915 (EC: IEA); GO_0042493 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS)
PMID: 1518805; 7829101; 9003395; 9799447; 12114189; 12387890; 12477932; 12591929; 14671211; 14707038; 14741744; 15136565; 15146197; 15336557; 15489334; 15545278; 16230742; 16391323; 16489205; 16808905; 16884492; 16936283; 17200350; 17322100; 17446422; 17620659; 17927964; 18188946; 18393390; 18606814; 18624398; 18827892; 18832575; 19054096; 19169702; 19351497; 19460752; 19602560; 19638644; 19843633; 19851831; 20032580; 20118912; 20143336; 20504295; 20661576; 20887090; 21566511; 21828233; 21906983; 22238364; 22496505; 22667335; 22949030; 22952953; 23129790; 23603836; 23688400
perilipin 2
Ensembl:ENSG00000147872
HGNC:248
HPRD:00057
MIM:103195
Vega:OTTHUMG00000019624
Other designations: adipophilin|adipose differentiation-related protein|perilipin-2
PLIN2
Bin Zhao, Yue Liu, Oliver He
ADH2
HEL-S-117
WEB: http://www.ncbi.nlm.nih.gov/gene
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
125
4q23
20140408
9606
4
protein-coding
Official from a nomenclature committee
GO_0004024 (EC: IDA, PMID: 9982); GO_0005829 (EC: TAS); GO_0006069 (EC: IDA, PMID: 2398055); GO_0006069 (EC: TAS); GO_0006805 (EC: TAS); GO_0008270 (EC: IDA, PMID: 9982); GO_0044281 (EC: TAS)
PMID: 9982; 1896463; 2169444; 2210383; 2295648; 2347582; 2398055; 2547609; 2679216; 2737681; 2935533; 2935875; 2986130; 3000832; 3006456; 3397059; 3619918; 6374651; 6391920; 8201622; 8663387; 8889548; 10424757; 10733556; 11051375; 11117576; 11238183; 11259352; 11274460; 11398342; 11410735; 11584144; 11696658; 11748356; 11781503; 11781511; 11966948; 12080432; 12081471; 12089173; 12153842; 12173598; 12189549; 12211622; 12213289; 12244546; 12351924; 12419833; 12452180; 12461493; 12477932; 12505800; 12517056; 12519453; 12545748; 12554615; 12658118; 12668919; 12710951; 12713190; 12777946; 12824748; 12884000; 12915514; 12915519; 14634838; 14693654; 14745297; 14768474; 15084894; 15162847; 15220553; 15318096; 15318112; 15327835; 15342556; 15456134; 15489334; 15511718; 15519646; 15534263; 15542751; 15597094; 15842823; 15863807; 15886702; 15902904; 15957670; 16006997; 16078602; 16086315; 16117582; 16127737; 16135443; 16163053; 16184481; 16235983; 16307179; 16309369; 16324524; 16332725; 16358724; 16385179; 16404797; 16423594; 16440362; 16520888; 16600530; 16608143; 16685648; 16702384; 16737450; 16758956; 16822169; 16930209; 16958672; 16970620; 17036331; 17071628; 17134659; 17134660; 17180580; 17185388; 17207821; 17250612; 17268812; 17279314; 17285601; 17289126; 17292341; 17293864; 17295732; 17421009; 17454860; 17471563; 17486761; 17489985; 17515815; 17517051; 17559546; 17618743; 17631643; 17762315; 17847010; 17850643; 17885622; 17923853; 17963305; 18033686; 18049455; 18056758; 18078815; 18216179; 18254707; 18266839; 18299763; 18322963; 18331377; 18336668; 18336671; 18382665; 18439068; 18500343; 18510611; 18516948; 18715275; 18761854; 18763293; 18773092; 18782342; 18784359; 18818748; 18936436; 18996923; 19019335; 19068087; 19094228; 19124091; 19124506; 19164089; 19185835; 19193628; 19250143; 19262484; 19298323; 19339270; 19343046; 19365573; 19403456; 19420105; 19449376; 19452585; 19469618; 19486361; 19527514; 19550411; 19618839; 19655364; 19667493; 19687126; 19698717; 19706845; 19751749; 19769429; 19799139; 19812523; 19826048; 19860798; 19861527; 19874574; 19887496; 19898482; 19913121; 19948975; 20010786; 20025435; 20031627; 20077761; 20101753; 20140262; 20171022; 20180859; 20205700; 20219057; 20336794; 20357489; 20401433; 20403997; 20437850; 20462248; 20477764; 20477767; 20494945; 20568895; 20598484; 20628086; 20634891; 20685249; 20700531; 20806441; 20833657; 21048924; 21133627; 21157980; 21166830; 21168396; 21284671; 21303386; 21351086; 21355870; 21378355; 21437268; 21497796; 21517275; 21576033; 21601984; 21635275; 21895720; 21917409; 21968928; 21988832; 22004471; 22048268; 22150722; 22231434; 22287615; 22292652; 22325912; 22363810; 22560290; 22674868; 22690706; 22703580; 22930414; 22931071; 22960999; 23149980; 23266708; 23285246; 23296215; 23414439; 23456092; 23468174; 23550892; 23615284; 23701534; 23743675; 23806636; 24217933
alcohol dehydrogenase 1B (class I), beta polypeptide
HGNC:250
HPRD:00065
MIM:103720
Other designations: ADH, beta subunit|alcohol dehydrogenase 1B|alcohol dehydrogenase 2 (class I), beta polypeptide|alcohol dehydrogenase subunit beta|aldehyde reductase|epididymis secretory protein Li 117
ADH1B
Bin Zhao, Yue Liu, Oliver He
bHLHe76
WEB: http://www.ncbi.nlm.nih.gov/gene
AHR
aryl hydrocarbon receptor
196
7p15
9606
7
Official from a nomenclature committee
GO_0000122 (EC: IEA); GO_0001568 (EC: NAS, PMID: 19538249); GO_0003677 (EC: IDA, PMID: 15681594); GO_0003677 (EC: TAS, PMID: 19538249); GO_0003700 (EC: IDA, PMID: 11782478); GO_0003705 (EC: IEA); GO_0004871 (EC: IEA); GO_0004879 (EC: IDA, PMID: 10395741); GO_0005515 (EC: IPI, PMID: 10395741); GO_0005634 (EC: IDA); GO_0005667 (EC: TAS, PMID: 19538249); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006355 (EC: IDA, PMID: 10395741); GO_0006357 (EC: IDA, PMID: 15681594); GO_0006366 (EC: IDA, PMID: 10395741); GO_0006805 (EC: TAS, PMID: 19538249); GO_0006915 (EC: TAS, PMID: 12213388); GO_0006950 (EC: IDA, PMID: 7961644); GO_0007049 (EC: TAS, PMID: 12213388); GO_0008134 (EC: IPI, PMID: 9079689); GO_0009410 (EC: IDA, PMID: 7961644); GO_0010468 (EC: IDA, PMID: 15681594); GO_0030522 (EC: IDA, PMID: 10395741); GO_0030850 (EC: IEA); GO_0030888 (EC: IDA, PMID: 15681594); GO_0034752 (EC: TAS, PMID: 19538249); GO_0043565 (EC: IEA); GO_0044212 (EC: IDA, PMID: 15681594); GO_0045899 (EC: IEA); GO_0046982 (EC: TAS, PMID: 19538249); GO_0046983 (EC: TAS, PMID: 19538249); GO_0051879 (EC: IDA, PMID: 9079689)
PMID: 7488247; 7515333; 7550366; 7566098; 7628454; 7716743; 7883760; 7961644; 7961671; 8074712; 8125016; 8246913; 8384309; 8393992; 8794892; 9079689; 9083006; 9111057; 9170146; 9446600; 9704006; 9712901; 9759704; 9787404; 9837941; 9887096; 9972449; 10048154; 10395741; 10428779; 10471301; 10497241; 10620335; 10644764; 10739168; 10903152; 10986286; 10999956; 11013261; 11032419; 11114727; 11207035; 11259606; 11259609; 11259615; 11393538; 11408954; 11425848; 11505220; 11689007; 11698344; 11742002; 11756572; 11768231; 11782478; 11805098; 11835227; 11866883; 12024042; 12065584; 12139968; 12181450; 12200463; 12203118; 12213388; 12213390; 12215427; 12237327; 12477932; 12480531; 12520072; 12566446; 12586752; 12592376; 12597446; 12612060; 12637498; 12690205; 12730383; 12774124; 12837759; 12852830; 12853948; 12917420; 14550747; 14560034; 14634838; 14973392; 14978034; 14985336; 15026081; 15069065; 15123621; 15190133; 15342792; 15474075; 15489334; 15499202; 15572374; 15641800; 15681594; 15728486; 15758562; 15774926; 15837795; 15863442; 15897893; 15917307; 15964790; 16084889; 16091746; 16103451; 16109480; 16153594; 16257957; 16337337; 16403814; 16480812; 16481407; 16538170; 16582008; 16619036; 16675542; 16762319; 16891617; 16922649; 16952353; 16985026; 16985033; 17053541; 17140257; 17174437; 17200336; 17209571; 17223712; 17244640; 17311112; 17392787; 17429315; 17490615; 17498780; 17502624; 17511620; 17552871; 17559847; 17596880; 17642299; 17823287; 17823304; 17900530; 17963696; 18029348; 18037991; 18059014; 18065768; 18259752; 18302886; 18303622; 18358233; 18359762; 18433817; 18483242; 18510611; 18515748; 18524851; 18628420; 18632753; 18636124; 18676680; 18677463; 18708059; 18708364; 18818557; 18923163; 18990750; 19013013; 19018768; 19027718; 19034627; 19114668; 19138996; 19158084; 19170196; 19255421; 19333233; 19340314; 19356061; 19356098; 19358281; 19360915; 19371443; 19380484; 19390533; 19415745; 19447902; 19460354; 19463884; 19465936; 19535631; 19536146; 19538249; 19556287; 19574409; 19592671; 19625176; 19651607; 19690180; 19692168; 19726680; 19736056; 19755661; 19789301; 19815066; 19821039; 19917880; 19941898; 20000589; 20032195; 20044593; 20053997; 20064835; 20130088; 20140206; 20146706; 20171126; 20237496; 20301892; 20354149; 20395535; 20401977; 20453000; 20460431; 20511231; 20619336; 20634891; 20676092; 20709182; 20804740; 20823264; 20878756; 20973933; 21072210; 21081473; 21205295; 21262915; 21316925; 21357676; 21374063; 21441140; 21462134; 21486221; 21490707; 21600206; 21613234; 21627536; 21640702; 21689841; 21693764; 21742528; 21804081; 21828262; 21878739; 21886157; 21906983; 21963094; 21976023; 21987572; 21988832; 21996739; 22052373; 22053597; 22071320; 22123295; 22138065; 22235307; 22273977; 22296396; 22311706; 22361730; 22388733; 22486318; 22495716; 22495806; 22539616; 22553215; 22596188; 22628113; 22649193; 22728919; 22754483; 22759865; 22761424; 22840970; 22854411; 22903824; 22915253; 23022626; 23030067; 23037589; 23141164; 23208493; 23228475; 23229511; 23288144; 23317198; 23370907; 23382382; 23419638; 23430108; 23439269; 23452206; 23492908; 23528250; 23583297; 23604401; 23614276; 23614742; 23723449; 23733406; 23802610; 23831623; 23994556; 24023334; 24091107; 24106308; 24302727; 24309559; 24316275; 24355420; 24380854
aryl hydrocarbon receptor
Ensembl:ENSG00000106546
HGNC:348
HPRD:02596
MIM:600253
Vega:OTTHUMG00000149967
Other designations: AH-receptor|ah receptor|aromatic hydrocarbon receptor|class E basic helix-loop-helix protein 76
AHR
Bin Zhao, Yue Liu, Oliver He
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
WEB: http://www.ncbi.nlm.nih.gov/gene
AKT1
v-akt murine thymoma viral oncogene homolog 1
207
14q32.32
9606
14
Official from a nomenclature committee
GO_0000060 (EC: IMP, PMID: 16280327); GO_0001649 (EC: IEA); GO_0001893 (EC: IEA); GO_0001934 (EC: IDA, PMID: 19057511); GO_0001938 (EC: IMP, PMID: 19850054); GO_0004672 (EC: TAS, PMID: 10570282); GO_0004674 (EC: IDA, PMID: 10102273); GO_0004674 (EC: TAS); GO_0005080 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11154276); GO_0005524 (EC: IC, PMID: 11994271); GO_0005524 (EC: IDA, PMID: 16540465); GO_0005547 (EC: IDA, PMID: 19203586); GO_0005634 (EC: IDA); GO_0005634 (EC: TAS); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 19203586); GO_0005737 (EC: ISS); GO_0005737 (EC: TAS); GO_0005819 (EC: IEA); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 14749367); GO_0005886 (EC: TAS); GO_0005978 (EC: IEA); GO_0005979 (EC: IMP, PMID: 8940145); GO_0006006 (EC: IEA); GO_0006412 (EC: IEA); GO_0006417 (EC: IEA); GO_0006464 (EC: TAS, PMID: 10570282); GO_0006468 (EC: IDA, PMID: 11994271); GO_0006469 (EC: IMP, PMID: 9373175); GO_0006469 (EC: ISS); GO_0006809 (EC: TAS, PMID: 10376602); GO_0006915 (EC: TAS); GO_0006924 (EC: IMP, PMID: 14749367); GO_0006954 (EC: IEA); GO_0007165 (EC: TAS); GO_0007173 (EC: TAS); GO_0007186 (EC: TAS, PMID: 10570282); GO_0007281 (EC: IEA); GO_0007568 (EC: IEA); GO_0007596 (EC: TAS); GO_0008283 (EC: TAS); GO_0008286 (EC: IMP, PMID: 8978681); GO_0008543 (EC: TAS); GO_0008637 (EC: IEA); GO_0009408 (EC: TAS, PMID: 10958679); GO_0010467 (EC: TAS); GO_0010507 (EC: IMP, PMID: 18387192); GO_0010748 (EC: IMP, PMID: 16814735); GO_0010765 (EC: IEA); GO_0010907 (EC: IMP, PMID: 16814735); GO_0010951 (EC: IMP, PMID: 18387192); GO_0010975 (EC: ISS); GO_0015630 (EC: IDA); GO_0015758 (EC: IEA); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0016301 (EC: IDA, PMID: 14749367); GO_0016310 (EC: IDA); GO_0016567 (EC: IEA); GO_0018105 (EC: IDA, PMID: 16139227); GO_0019899 (EC: ISS); GO_0030030 (EC: IEA); GO_0030154 (EC: TAS); GO_0030163 (EC: IEA); GO_0030168 (EC: TAS); GO_0030212 (EC: IEA); GO_0030235 (EC: IMP, PMID: 10376603); GO_0030307 (EC: IDA, PMID: 19203586); GO_0030334 (EC: IMP, PMID: 19934221); GO_0030334 (EC: TAS); GO_0031018 (EC: TAS); GO_0031295 (EC: TAS); GO_0031659 (EC: IDA, PMID: 18483258); GO_0031999 (EC: IMP, PMID: 16814735); GO_0032094 (EC: IEA); GO_0032270 (EC: ISS); GO_0032287 (EC: IEA); GO_0032436 (EC: IEA); GO_0032869 (EC: IMP, PMID: 16814735); GO_0032869 (EC: ISS); GO_0033138 (EC: IDA, PMID: 19667065); GO_0034405 (EC: IMP, PMID: 10376603); GO_0035556 (EC: IDA, PMID: 14749367); GO_0038095 (EC: TAS); GO_0042593 (EC: IEA); GO_0042640 (EC: IEA); GO_0042802 (EC: IPI, PMID: 7891724); GO_0043065 (EC: IEA); GO_0043066 (EC: IDA, PMID: 19203586); GO_0043154 (EC: ISS); GO_0043325 (EC: IDA, PMID: 19203586); GO_0043491 (EC: IEA); GO_0043536 (EC: IDA); GO_0044281 (EC: TAS); GO_0045087 (EC: TAS); GO_0045429 (EC: IMP, PMID: 10376603); GO_0045600 (EC: IMP, PMID: 8940145); GO_0045725 (EC: IMP, PMID: 16814735); GO_0045725 (EC: NAS, PMID: 17925406); GO_0045792 (EC: IEA); GO_0045861 (EC: IMP, PMID: 18387192); GO_0045907 (EC: IEA); GO_0045944 (EC: IEA); GO_0046209 (EC: TAS); GO_0046326 (EC: IMP, PMID: 16814735); GO_0046329 (EC: IEA); GO_0046777 (EC: TAS, PMID: 16280327); GO_0046889 (EC: IMP, PMID: 8940145); GO_0048009 (EC: IMP, PMID: 8978681); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050999 (EC: TAS); GO_0051000 (EC: IMP, PMID: 10376603); GO_0051091 (EC: IDA, PMID: 19057511); GO_0051146 (EC: IEA); GO_0060644 (EC: TAS); GO_0060709 (EC: IEA); GO_0060716 (EC: IEA); GO_0061024 (EC: TAS); GO_0070141 (EC: IDA, PMID: 18483258); GO_0071260 (EC: IEA); GO_0071364 (EC: IEA); GO_0071456 (EC: IEA); GO_0071889 (EC: IPI, PMID: 10102273); GO_0090004 (EC: IMP, PMID: 8940145); GO_0090201 (EC: ISS); GO_0097193 (EC: TAS); GO_0097194 (EC: IEA); GO_1900740 (EC: TAS); GO_1901976 (EC: TAS); GO_1902176 (EC: NAS, PMID: 16604263); GO_2001240 (EC: TAS, PMID: 10748004)
PMID: 1533586; 1718748; 1851997; 3037531; 3384441; 7774014; 7891724; 8524413; 8940145; 8978681; 9005852; 9019819; 9312003; 9368760; 9373175; 9381178; 9394803; 9395488; 9512493; 9736715; 9768361; 9812896; 9829964; 9973250; 10082674; 10085094; 10102273; 10217147; 10224060; 10226025; 10358014; 10376602; 10376603; 10438924; 10454575; 10485710; 10485711; 10490823; 10490848; 10491192; 10497255; 10527852; 10542266; 10570282; 10576742; 10617634; 10635328; 10698680; 10748004; 10833263; 10866658; 10869359; 10869418; 10872470; 10896934; 10910062; 10926925; 10930578; 10958679; 10983986; 10995457; 11035810; 11042204; 11116148; 11139588; 11154276; 11154281; 11156376; 11156964; 11162552; 11208609; 11274386; 11278835; 11278894; 11313365; 11313479; 11404460; 11410590; 11410591; 11425855; 11438723; 11445557; 11500364; 11504915; 11508278; 11509608; 11535620; 11546794; 11579209; 11583630; 11585925; 11598301; 11689711; 11696579; 11707444; 11707464; 11710897; 11715018; 11723139; 11756412; 11773441; 11777913; 11782427; 11809791; 11825911; 11828257; 11855836; 11877387; 11884598; 11902142; 11903042; 11923280; 11956222; 11960368; 11976320; 11994271; 11994280; 12009899; 12011046; 12042314; 12062056; 12062094; 12070137; 12077256; 12112022; 12124386; 12138087; 12138205; 12145204; 12149249; 12150915; 12167664; 12167717; 12176337; 12176338; 12176997; 12194869; 12218048; 12244133; 12244301; 12244302; 12244303; 12297295; 12376533; 12393747; 12438239; 12446767; 12446787; 12446789; 12458207; 12477932; 12524439; 12527373; 12529294; 12535517; 12586360; 12592338; 12621049; 12637511; 12722480; 12727836; 12734380; 12741986; 12750378; 12757707; 12768030; 12782295; 12783873; 12791994; 12808085; 12808093; 12853467; 12874217; 12888921; 12919677; 12952968; 12972603; 14499622; 14500673; 14505491; 14520710; 14523021; 14534536; 14560023; 14566704; 14568991; 14611643; 14612949; 14623889; 14625285; 14636889; 14645242; 14645548; 14647146; 14657000; 14679206; 14702039; 14713953; 14742298; 14749367; 14749388; 14749719; 14755253; 14761976; 14970221; 14973226; 14985374; 15001646; 15010337; 15016818; 15026145; 15047604; 15047866; 15060171; 15067058; 15102693; 15115729; 15118108; 15136501; 15146197; 15149849; 15156201; 15173318; 15183529; 15187088; 15187138; 15194442; 15203190; 15217935; 15231831; 15242771; 15262962; 15262978; 15263908; 15271644; 15283964; 15284024; 15306850; 15316080; 15326564; 15331441; 15342781; 15342917; 15385469; 15388791; 15389633; 15459205; 15465021; 15467757; 15470047; 15475446; 15489334; 15492215; 15522255; 15525681; 15527798; 15533996; 15539407; 15545269; 15545271; 15545519; 15546863; 15572689; 15574337; 15580267; 15581622; 15607733; 15609321; 15616007; 15665327; 15665818; 15668028; 15678105; 15688030; 15689238; 15705789; 15710591; 15718470; 15722337; 15723049; 15743789; 15778376; 15784622; 15800029; 15802268; 15806160; 15808505; 15809304; 15817639; 15818404; 15831676; 15833736; 15837948; 15840729; 15843522; 15845076; 15845651; 15856005; 15861136; 15879168; 15888491; 15896313; 15896703; 15905178; 15910284; 15911620; 15922745; 15961723; 15982448; 15987444; 15993382; 15994200; 15998799; 16007092; 16007163; 16007172; 16007182; 16009706; 16012720; 16019536; 16026766; 16027121; 16027165; 16027169; 16036916; 16049004; 16049961; 16055703; 16076959; 16091017; 16098514; 16099944; 16107690; 16114056; 16115861; 16123141; 16128748; 16139227; 16141217; 16142341; 16148125; 16160160; 16163388; 16174774; 16177823; 16186112; 16202996; 16210317; 16216590; 16224021; 16243840; 16263580; 16272144; 16274701; 16278380; 16280327; 16282323; 16293694; 16338927; 16354698; 16362038; 16365168; 16373405; 16395129; 16405925; 16407258; 16407271; 16412424; 16417524; 16428439; 16434970; 16453020; 16466644; 16474850; 16478297; 16508008; 16524887; 16532026; 16532036; 16537497; 16540465; 16543232; 16549426; 16551632; 16564100; 16568092; 16571745; 16583435; 16601838; 16603397; 16604263; 16613989; 16616456; 16644866; 16651639; 16670089; 16682946; 16684529; 16723503; 16732486; 16763222; 16774943; 16775835; 16785234; 16790501; 16790529; 16792529; 16797529; 16814735; 16818690; 16820098; 16820947; 16822839; 16836907; 16839745; 16840713; 16841089; 16842970; 16844778; 16849522; 16862180; 16897758; 16912864; 16916907; 16926151; 16932738; 16946008; 16951146; 16962653; 16972255; 16977260; 16981720; 16982329; 16987028; 16987250; 16988010; 16990258; 17006541; 17006756; 17008323; 17012749; 17015676; 17016437; 17024099; 17030608; 17041888; 17043653; 17050554; 17052453; 17060455; 17065200; 17068339; 17081983; 17088265; 17097759; 17098228; 17099727; 17113264; 17128418; 17136479; 17136481; 17141917; 17143278; 17148458; 17151107; 17157319; 17169805; 17173971; 17179152; 17210635; 17214972; 17215852; 17233643; 17235455; 17244606; 17274640; 17276404; 17287851; 17299206; 17300918; 17307335; 17310852; 17317726; 17317825; 17318185; 17318262; 17333095; 17335965; 17342093; 17349711; 17351066; 17360849; 17375124; 17383860; 17386267; 17400190; 17404186; 17406055; 17428466; 17443665; 17458890; 17461449; 17462862; 17468516; 17469127; 17470458; 17471535; 17478078; 17483438; 17493174; 17495954; 17495959; 17501982; 17504381; 17505062; 17507655; 17507800; 17512923; 17513297; 17513702; 17520698; 17521720; 17522055; 17522703; 17533377; 17535800; 17544405; 17544543; 17546049; 17549359; 17551921; 17553806; 17554339; 17565979; 17566113; 17569669; 17577629; 17580302; 17581609; 17584963; 17594810; 17599831; 17599906; 17601486; 17606718; 17609269; 17611497; 17612563; 17615157; 17616681; 17616684; 17616691; 17635910; 17638918; 17666398; 17681738; 17687643; 17696196; 17706139; 17712528; 17716861; 17721885; 17721920; 17725107; 17726016; 17761832; 17804197; 17804734; 17822324; 17823925; 17825267; 17825284; 17826033; 17827393; 17855350; 17868340; 17883592; 17890457; 17891137; 17892507; 17895832; 17898861; 17901375; 17906677; 17909223; 17914025; 17914096; 17915974; 17921701; 17924977; 17925406; 17925408; 17927847; 17928528; 17932490; 17935714; 17950696; 17951252; 17957242; 17959676; 17960583; 17962807; 17977950; 18021174; 18023414; 18029348; 18035048; 18037896; 18041764; 18046412; 18048359; 18048937; 18053070; 18059161; 18063683; 18064631; 18071906; 18072631; 18079201; 18083769; 18087195; 18097023; 18167217; 18172656; 18174256; 18182168; 18182859; 18184439; 18187454; 18187620; 18191226; 18194602; 18197291; 18198266; 18199533; 18199536; 18201823; 18204201; 18204829; 18216097; 18227124; 18231751; 18240972; 18247380; 18249092; 18256540; 18262492; 18264090; 18270579; 18273051; 18292230; 18300076; 18309287; 18316593; 18317451; 18319625; 18323784; 18331557; 18332138; 18332867; 18332868; 18339899; 18351386; 18353776; 18355439; 18355897; 18356162; 18374639; 18387192; 18392055; 18395956; 18395980; 18398749; 18400376; 18404535; 18409144; 18410456; 18411301; 18413665; 18420583; 18425364; 18434090; 18437054; 18439422; 18440314; 18450971; 18451027; 18451140; 18458059; 18458087; 18466879; 18469852; 18479604; 18483258; 18483275; 18487214; 18487454; 18490760; 18495460; 18497887; 18499442; 18504432; 18505677; 18505846; 18509361; 18512729; 18519641; 18519679; 18524825; 18550470; 18552504; 18562279; 18562319; 18566587; 18574502; 18583979; 18593948; 18596081; 18606817; 18611285; 18611860; 18617528; 18622039; 18624398; 18625725; 18635704; 18635812; 18639865; 18640717; 18644989; 18644990; 18650932; 18660489; 18665177; 18668138; 18673414; 18676680; 18676830; 18676874; 18678286; 18682509; 18686341; 18687691; 18689794; 18701703; 18701709; 18711014; 18711316; 18713840; 18714568; 18718903; 18720410; 18723000; 18725974; 18728011; 18728784; 18754328; 18767116; 18769058; 18769147; 18769720; 18771702; 18774962; 18776922; 18782222; 18782353; 18783292; 18790560; 18794113; 18798227; 18798258; 18802038; 18813808; 18813944; 18824170; 18826385; 18826950; 18829502; 18838169; 18838251; 18838536; 18841391; 18844239; 18855532; 18922901; 18924134; 18931307; 18936167; 18937284; 18948104; 18948272; 18949384; 18954143; 18974133; 18976975; 18981248; 18981303; 18996102; 18996844; 19002588; 19010915; 19011679; 19017490; 19017978; 19018001; 19020711; 19020728; 19029952; 19048112; 19050243; 19050262; 19051289; 19054571; 19057511; 19058874; 19059380; 19062713; 19067848; 19068477; 19068483; 19070520; 19073147; 19074768; 19074832; 19074868; 19074885; 19074894; 19078992; 19079342; 19091404; 19095734; 19098000; 19103742; 19107873; 19109741; 19110052; 19114998; 19115062; 19116269; 19116273; 19118218; 19124015; 19132987; 19136058; 19138978; 19142871; 19142997; 19144640; 19147496; 19147772; 19151754; 19158829; 19160403; 19162005; 19164214; 19170196; 19176054; 19176518; 19176689; 19179443; 19188658; 19193378; 19201817; 19203586; 19219602; 19219857; 19224164; 19229860; 19236051; 19239323; 19240722; 19240976; 19250936; 19250983; 19261608; 19261616; 19262695; 19267882; 19270310; 19270694; 19270695; 19276265; 19278624; 19286607; 19303863; 19318457; 19323811; 19324870; 19328625; 19339247; 19353338; 19356729; 19357198; 19367581; 19376889; 19377290; 19389506; 19405949; 19406989; 19407222; 19409087; 19415690; 19417030; 19418217; 19420344; 19428048; 19429661; 19435822; 19437103; 19447872; 19453261; 19453843; 19457567; 19458356; 19461960; 19473116; 19473971; 19479051; 19479902; 19481529; 19482076; 19483721; 19484147; 19487299; 19488783; 19489223; 19491896; 19492080; 19503105; 19520917; 19526459; 19533041; 19538940; 19541408; 19549627; 19553815; 19556867; 19560862; 19564927; 19567200; 19574087; 19584164; 19588500; 19589780; 19590514; 19592491; 19595713; 19596916; 19597469; 19609946; 19621391; 19622295; 19622752; 19625176; 19628576; 19633364; 19635908; 19636556; 19638627; 19639178; 19639199; 19641183; 19644051; 19646290; 19649722; 19655166; 19655410; 19655414; 19657064; 19662361; 19667065; 19676105; 19679016; 19681907; 19684620; 19692168; 19700402; 19713228; 19713527; 19721393; 19723094; 19723095; 19726550; 19726736; 19726747; 19727814; 19729990; 19736361; 19738422; 19744127; 19745829; 19747927; 19748889; 19754670; 19757167; 19764563; 19765303; 19767770; 19775474; 19776120; 19781633; 19787271; 19797085; 19799812; 19801633; 19801684; 19802009; 19802016; 19805522; 19815051; 19815552; 19815839; 19816934; 19820359; 19825827; 19833727; 19835871; 19836430; 19850036; 19850054; 19853286; 19855431; 19864499; 19875456; 19875696; 19878271; 19881543; 19882362; 19885574; 19885581; 19887561; 19887570; 19889638; 19889640; 19891769; 19897009; 19898424; 19903888; 19913121; 19917135; 19920252; 19922411; 19924282; 19925030; 19926313; 19931325; 19933775; 19934221; 19935854; 19940129; 19948975; 19953087; 19954644; 19956840; 19956847; 19965664; 19966853; 19995607; 19997873; 20003467; 20005908; 20008098; 20008289; 20012528; 20018888; 20018937; 20018949; 20019835; 20019839; 20022634; 20026048; 20026773; 20028853; 20030877; 20033742; 20041213; 20041238; 20042122; 20046382; 20048146; 20053726; 20054340; 20055757; 20056178; 20059950; 20067111; 20072648; 20081374; 20086095; 20086174; 20088406; 20093341; 20098747; 20100200; 20101210; 20102399; 20103602; 20106550; 20107185; 20109457; 20110348; 20126987; 20127017; 20127709; 20132317; 20133737; 20141546; 20154081; 20157733; 20159991; 20164223; 20164304; 20173664; 20182617; 20186153; 20186503; 20187936; 20190811; 20198299; 20201953; 20214684; 20216540; 20228224; 20231902; 20232298; 20237237; 20301425; 20306497; 20307589; 20308328; 20332111; 20333297; 20333651; 20336670; 20339081; 20339252; 20346214; 20346360; 20347887; 20354121; 20360004; 20361045; 20361981; 20362557; 20368287; 20371257; 20372801; 20372806; 20383191; 20388781; 20389136; 20395438; 20398329; 20400976; 20400979; 20407443; 20410674; 20412774; 20414143; 20416077; 20417028; 20419107; 20421846; 20432460; 20432929; 20436671; 20447721; 20453000; 20457218; 20458733; 20459571; 20471940; 20478633; 20484047; 20488790; 20490331; 20492754; 20493625; 20506505; 20506537; 20509930; 20512574; 20512787; 20513428; 20514448; 20514451; 20516073; 20520724; 20523723; 20525693; 20526288; 20530239; 20530298; 20530554; 20530982; 20534535; 20536315; 20541701; 20555032; 20557351; 20560677; 20562913; 20566894; 20574456; 20578837; 20585556; 20585984; 20586915; 20592362; 20595063; 20600027; 20605778; 20607350; 20620179; 20622004; 20622047; 20623644; 20628086; 20643654; 20648653; 20651405; 20657188; 20661303; 20671123; 20672329; 20679348; 20682768; 20687898; 20688159; 20693286; 20697673; 20703095; 20723296; 20725137; 20726858; 20731018; 20734064; 20805333; 20808831; 20818434; 20818790; 20826237; 20829512; 20837477; 20838929; 20844931; 20854947; 20856200; 20860430; 20863633; 20864106; 20872231; 20878056; 20886116; 20886414; 20921115; 20940316; 20947498; 20956948; 20957008; 20957047; 20959404; 20975834; 20978158; 20980511; 20980808; 21029719; 21035469; 21035497; 21040950; 21041608; 21042744; 21042767; 21044950; 21045156; 21045158; 21045808; 21048031; 21049487; 21059203; 21061022; 21062993; 21075859; 21078168; 21082206; 21087080; 21092549; 21093899; 21106245; 21110830; 21113787; 21118808; 21127195; 21127264; 21129241; 21131356; 21135252; 21139048; 21151116; 21151390; 21159778; 21168265; 21169559; 21177249; 21177334; 21185392; 21191179; 21209368; 21212269; 21212275; 21228233; 21238503; 21242970; 21253589; 21254169; 21255011; 21263216; 21266843; 21276823; 21284870; 21288887; 21289304; 21289308; 21290341; 21294052; 21295396; 21297666; 21308747; 21309701; 21320536; 21321111; 21321378; 21325624; 21333377; 21334199; 21339740; 21343617; 21355052; 21358672; 21365510; 21370247; 21380726; 21385902; 21390332; 21391741; 21394210; 21396404; 21405945; 21406404; 21407808; 21412012; 21423810; 21430300; 21432781; 21436142; 21437936; 21440011; 21440577; 21442372; 21444773; 21445305; 21454528; 21454539; 21454620; 21460223; 21464307; 21464312; 21464729; 21468601; 21474332; 21474915; 21478156; 21480388; 21482133; 21483469; 21487020; 21490677; 21499215; 21501368; 21507933; 21513698; 21521253; 21532145; 21536374; 21539865; 21557211; 21566129; 21570709; 21590431; 21592330; 21592956; 21606541; 21609291; 21621563; 21623170; 21624038; 21632881; 21633372; 21646299; 21646525; 21658387; 21659549; 21660042; 21667138; 21669872; 21670080; 21673026; 21673516; 21680733; 21685937; 21696297; 21697490; 21701506; 21705328; 21707707; 21708191; 21709150; 21713404; 21715568; 21718677; 21720709; 21722267; 21732363; 21741444; 21742779; 21742938; 21750652; 21757645; 21757743; 21763505; 21765914; 21767636; 21775008; 21775054; 21775285; 21775495; 21775978; 21777568; 21777670; 21778238; 21788944; 21793738; 21794903; 21799016; 21819378; 21824802; 21828040; 21828127; 21832049; 21837363; 21837670; 21840940; 21842521; 21849454; 21855541; 21856935; 21859846; 21862580; 21868077; 21869603; 21872252; 21873248; 21873430; 21874010; 21878648; 21878679; 21880746; 21881167; 21884932; 21887250; 21890473; 21890492; 21900206; 21901101; 21906983; 21908613; 21908615; 21908616; 21910869; 21913799; 21914810; 21915031; 21915327; 21925532; 21930127; 21939655; 21945955; 21949775; 21954225; 21959954; 21975932; 21975935; 21978279; 21980128; 21987722; 21991300; 21994334; 22005766; 22014666; 22021428; 22029423; 22031597; 22031698; 22033727; 22045027; 22051934; 22070874; 22072736; 22084251; 22093097; 22094587; 22095135; 22105580; 22107784; 22116552; 22116667; 22117074; 22131882; 22140653; 22146375; 22146979; 22150081; 22169232; 22171994; 22173970; 22174934; 22183914; 22184110; 22185283; 22189542; 22192357; 22198382; 22199277; 22199300; 22199303; 22208359; 22213015; 22213475; 22231444; 22234835; 22235305; 22249415; 22251423; 22268450; 22270359; 22271581; 22277669; 22280833; 22285928; 22297255; 22301279; 22309289; 22314363; 22315412; 22328503; 22328975; 22334668; 22335196; 22336203; 22337773; 22339676; 22340730; 22343475; 22345097; 22351695; 22354785; 22360859; 22363436; 22363598; 22366458; 22375056; 22384056; 22384099; 22384145; 22389405; 22391209; 22391563; 22393424; 22394200; 22394497; 22394561; 22410793; 22417847; 22426999; 22430898; 22445357; 22451658; 22455883; 22457005; 22463491; 22465665; 22471665; 22480519; 22480544; 22487681; 22488590; 22491319; 22494103; 22496232; 22505016; 22508044; 22525159; 22532149; 22535956; 22539090; 22547695; 22552281; 22552284; 22554284; 22562131; 22563025; 22563076; 22567126; 22569334; 22569400; 22571340; 22575839; 22577119; 22588279; 22590527; 22591684; 22607554; 22614013; 22619175; 22626691; 22647853; 22648906; 22674407; 22675553; 22682934; 22685591; 22687243; 22705004; 22706160; 22727668; 22728329; 22740686; 22748472; 22752602; 22760211; 22768179; 22805337; 22808143; 22809628; 22815832; 22831980; 22833150; 22837212; 22840496; 22842582; 22875023; 22876373; 22895070; 22895078; 22896661; 22897592; 22901187; 22904195; 22905202; 22905203; 22907434; 22910909; 22923366; 22928011; 22929028; 22936801; 22938585; 22945510; 22952709; 22954457; 22957045; 22961111; 22964641; 22967500; 22975685; 22990118; 22995914; 23021375; 23035900; 23039130; 23041284; 23043959; 23046567; 23047954; 23060458; 23069661; 23082158; 23092880; 23092893; 23095753; 23097134; 23107319; 23112296; 23125486; 23127761; 23133535; 23134728; 23135917; 23135998; 23138182; 23147115; 23167739; 23169238; 23176396; 23182717; 23185040; 23188060; 23192081; 23192871; 23195959; 23200933; 23205493; 23208492; 23225414; 23227138; 23235274; 23236232; 23237847; 23246288; 23249714; 23255608; 23261389; 23271397; 23272133; 23280503; 23297824; 23300340; 23300741; 23303682; 23314850; 23315288; 23318419; 23319332; 23321169; 23325864; 23334667; 23338526; 23340251; 23340270; 23348505; 23352210; 23354687; 23354912; 23379509; 23380710; 23383273; 23384770; 23386617; 23389849; 23409016; 23409128; 23417403; 23418602; 23419514; 23421998; 23424671; 23429328; 23430973; 23434580; 23437141; 23440515; 23442539; 23444215; 23457304; 23457334; 23459592; 23463506; 23463670; 23474367; 23499907; 23504323; 23507869; 23511556; 23512990; 23521913; 23525579; 23546174; 23546450; 23546602; 23547889; 23553960; 23558942; 23561972; 23563091; 23563706; 23567263; 23574721; 23580656; 23583197; 23603894; 23613227; 23615537; 23615713; 23624506; 23625205; 23626817; 23629924; 23639623; 23640046; 23667466; 23677479; 23684008; 23685151; 23686362; 23708780; 23710442; 23710710; 23711387; 23724143; 23725225; 23726842; 23728071; 23740762; 23741320; 23742646; 23743572; 23754751; 23757022; 23765166; 23786162; 23788636; 23791833; 23792459; 23792604; 23796964; 23811754; 23812726; 23824745; 23832540; 23838801; 23840064; 23841076; 23843462; 23852728; 23863161; 23867821; 23869765; 23876532; 23884311; 23884447; 23884910; 23886157; 23896866; 23898095; 23923067; 23934627; 23996929; 24001613; 24005670; 24015256; 24030155; 24081328; 24095799; 24099783; 24113181; 24120917; 24152492; 24154876; 24157255; 24225136; 24297901; 24314632; 24321521; 24458280; 24600969
v-akt murine thymoma viral oncogene homolog 1
Ensembl:ENSG00000142208
HGNC:391
HPRD:01261
MIM:164730
Vega:OTTHUMG00000170795
Other designations: PKB alpha|RAC-PK-alpha|RAC-alpha serine/threonine-protein kinase|protein kinase B alpha|proto-oncogene c-Akt|rac protein kinase alpha
AKT1
Bin Zhao, Yue Liu, Oliver He
HIHGHH
PKBB
PKBBETA
PRKBB
RAC-BETA
WEB: http://www.ncbi.nlm.nih.gov/gene
AKT2
v-akt murine thymoma viral oncogene homolog 2
208
19q13.1-q13.2
9606
19
Official from a nomenclature committee
GO_0001934 (EC: ISS); GO_0004674 (EC: IDA, PMID: 16540465); GO_0004674 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10490823); GO_0005524 (EC: IDA, PMID: 16540465); GO_0005634 (EC: IDA); GO_0005634 (EC: TAS); GO_0005829 (EC: TAS); GO_0005886 (EC: ISS); GO_0005886 (EC: TAS); GO_0005938 (EC: ISS); GO_0005978 (EC: IEA); GO_0006006 (EC: IEA); GO_0006417 (EC: IEA); GO_0006464 (EC: TAS, PMID: 1409633); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS); GO_0008286 (EC: IMP, PMID: 16814735); GO_0008286 (EC: TAS); GO_0008643 (EC: IEA); GO_0010748 (EC: IMP, PMID: 16814735); GO_0010907 (EC: IMP, PMID: 16814735); GO_0016301 (EC: TAS); GO_0030334 (EC: TAS); GO_0031340 (EC: ISS); GO_0032000 (EC: IMP, PMID: 16814735); GO_0032287 (EC: IEA); GO_0032587 (EC: ISS); GO_0032859 (EC: IEA); GO_0032869 (EC: IMP, PMID: 16814735); GO_0045444 (EC: TAS); GO_0045725 (EC: IMP, PMID: 16814735); GO_0046326 (EC: IMP, PMID: 16814735); GO_0060644 (EC: TAS); GO_0061024 (EC: TAS); GO_0065002 (EC: ISS); GO_0071156 (EC: TAS); GO_0072659 (EC: IEA); GO_0090314 (EC: ISS); GO_2000147 (EC: IMP, PMID: 17332325); GO_2001275 (EC: IEA)
PMID: 1409633; 1801921; 3037531; 8622988; 8889548; 9374542; 9394803; 9512493; 9528769; 9736715; 10490823; 10491192; 10869418; 10983986; 11139588; 11156964; 11208609; 11278835; 11313479; 11432835; 11445557; 11500317; 11507039; 11546794; 11707444; 11781143; 11903042; 11948187; 11988487; 11994280; 12048203; 12114503; 12149249; 12167664; 12176337; 12176997; 12181350; 12434148; 12477932; 12480711; 12482965; 12517337; 12517798; 12524439; 12545160; 12663464; 12697749; 12733712; 12791994; 12808085; 14500673; 14504284; 14612499; 14637151; 14645242; 14654898; 14699494; 14702039; 14735903; 14973226; 15010337; 15070827; 15102693; 15111130; 15144186; 15146197; 15166380; 15314020; 15489334; 15531580; 15557754; 15616007; 15678105; 15689238; 15890450; 15987444; 16221682; 16365168; 16402276; 16524887; 16540465; 16814735; 16841089; 16982699; 17012749; 17030088; 17157319; 17276404; 17327441; 17332325; 17349711; 17372934; 17482291; 17535800; 17576055; 17577629; 17804734; 17825284; 17895832; 17908691; 17914025; 17962807; 18048359; 18187620; 18281467; 18300076; 18316591; 18353613; 18660489; 18768676; 18826950; 18842333; 18996102; 19064572; 19074768; 19075230; 19079138; 19110052; 19164214; 19197940; 19261608; 19435822; 19453261; 19479051; 19713527; 19771908; 19797172; 19825827; 19843246; 19875456; 19913121; 19933843; 20012528; 20018949; 20019835; 20041213; 20056178; 20056908; 20059950; 20102399; 20109457; 20116920; 20133737; 20167810; 20186503; 20354455; 20398329; 20409325; 20447721; 20514445; 20602615; 20628086; 20661303; 20687898; 20688159; 20691427; 20818790; 20848774; 20856200; 21029719; 21048031; 21050850; 21092549; 21179235; 21182834; 21297943; 21423810; 21432781; 21483469; 21507933; 21518566; 21590431; 21606541; 21618512; 21636708; 21680733; 21697490; 21722267; 21763505; 21765914; 21832049; 21890473; 21906983; 21932427; 21979934; 21979951; 21988832; 22031698; 22107784; 22158034; 22261254; 22480544; 22556379; 22748472; 22778840; 22809628; 22904195; 22939624; 22952844; 23018889; 23092922; 23250987; 23305873; 23321478; 23444369; 23468863; 23567263; 23777806; 24030155; 24056770; 24250222; 24321521
v-akt murine thymoma viral oncogene homolog 2
Ensembl:ENSG00000105221
HGNC:392
HPRD:01262
MIM:164731
Vega:OTTHUMG00000137375
Other designations: PKB beta|RAC-PK-beta|RAC-beta serine/threonine-protein kinase|murine thymoma viral (v-akt) homolog-2|protein kinase Akt-2|protein kinase B beta|rac protein kinase beta
AKT2
Bin Zhao, Yue Liu, Oliver He
ALAS
ALAS3
ALASH
MIG4
WEB: http://www.ncbi.nlm.nih.gov/gene
ALAS1
aminolevulinate, delta-, synthase 1
211
OK/SW-cl.121
3p21.1
9606
3
Official from a nomenclature committee
GO_0003870 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005759 (EC: TAS); GO_0006778 (EC: TAS); GO_0006782 (EC: IEA); GO_0006783 (EC: TAS); GO_0030170 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS)
PMID: 2095458; 2263504; 2347585; 3671094; 7698013; 8424176; 11267664; 11566198; 11929042; 11929048; 12433930; 12477932; 12878157; 15028279; 15123725; 15477213; 15489334; 15547665; 15710391; 15797241; 16234850; 16730941; 16751776; 17628775; 17672918; 18029348; 18719978; 19460752; 19477221; 19656447; 19913121; 20237496; 20628086; 20877624; 21048031; 21659532; 21900206; 21906983; 21926972; 21963094; 21987572; 21988832; 22505724; 23024262; 23974872; 24250222
aminolevulinate, delta-, synthase 1
Ensembl:ENSG00000023330
HGNC:396
HPRD:00505
MIM:125290
Vega:OTTHUMG00000158108
Other designations: 5-aminolevulinate synthase, nonspecific, mitochondrial|5-aminolevulinic acid synthase 1|ALAS-H|delta-ALA synthase 1|delta-aminolevulinate synthase 1|migration-inducing protein 4
ALAS1
Bin Zhao, Yue Liu, Oliver He
ALDC
ALDH-E1
ALDH1
ALDH11
HEL-9
HEL-S-53e
HEL12
PUMB1
RALDH1
WEB: http://www.ncbi.nlm.nih.gov/gene
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
216
RP11-151D14.2
9q21.13
9606
9
Official from a nomenclature committee
GO_0001758 (EC: IEA); GO_0004029 (EC: EXP); GO_0005099 (EC: TAS, PMID: 1709013); GO_0005497 (EC: TAS, PMID: 1709013); GO_0005737 (EC: TAS, PMID: 2987944); GO_0005829 (EC: TAS); GO_0006069 (EC: TAS); GO_0006081 (EC: TAS, PMID: 1709013); GO_0006805 (EC: TAS); GO_0032320 (EC: TAS, PMID: 1709013); GO_0042572 (EC: IEA); GO_0044281 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
PMID: 224930; 730161; 1709013; 2591967; 2776714; 2987944; 3013004; 3397064; 3676276; 4015823; 6427007; 6723659; 8214422; 8493914; 9166904; 9240474; 9723161; 12081471; 12174908; 12477932; 14506398; 14678778; 15489334; 15597079; 15852347; 16189514; 16857736; 16878979; 17175089; 17222227; 17286337; 17502835; 17628022; 18029348; 18082256; 18331377; 18343808; 18371393; 18450747; 18496131; 18644979; 18848913; 18854779; 19018242; 19025616; 19056867; 19129088; 19296407; 19329942; 19343046; 19385968; 19447584; 19450560; 19478994; 19696793; 19703508; 19706361; 19774675; 19808966; 19874574; 19911270; 20010854; 20019840; 20142235; 20228222; 20379614; 20422001; 20516116; 20585849; 20596639; 20606680; 20634891; 20889728; 20959018; 20959469; 21045151; 21098716; 21118965; 21231983; 21282737; 21336637; 21371077; 21399615; 21441790; 21482329; 21695188; 21708005; 21804471; 21827011; 21907803; 21988832; 22005464; 22012766; 22014057; 22080062; 22098156; 22101256; 22115706; 22123295; 22131125; 22195027; 22260461; 22380773; 22417385; 22430847; 22544210; 22581680; 22591209; 22608744; 22617249; 22649953; 22710732; 22725270; 22782852; 22877687; 22878609; 22887839; 22899292; 22928012; 22930220; 22938492; 23084350; 23112116; 23132408; 23220285; 23236537; 23252868; 23267077; 23295229; 23332924; 23434145; 23438482; 23454351; 23465277; 23483187; 23585015; 23759596; 23762304; 23787917; 23799031; 23805041; 23845466; 24043631; 24080087; 24120944; 24289252; 24511023
aldehyde dehydrogenase 1 family, member A1
Ensembl:ENSG00000165092
HGNC:402
HPRD:00001
MIM:100640
Vega:OTTHUMG00000020019
Other designations: ALDH class 1|ALHDII|RALDH 1|acetaldehyde dehydrogenase 1|aldehyde dehydrogenase 1, soluble|aldehyde dehydrogenase, liver cytosolic|epididymis luminal protein 12|epididymis luminal protein 9|epididymis secretory sperm binding protein Li 53e|retinal dehydrogenase 1|retinaldehyde dehydrogenase 1
ALDH1A1
Bin Zhao, Yue Liu, Oliver He
ALDB
ALDO2
WEB: http://www.ncbi.nlm.nih.gov/gene
ALDOB
aldolase B, fructose-bisphosphate
229
RP11-490D19.1
9q21.3-q22.2
20140408
9606
9
protein-coding
Official from a nomenclature committee
GO_0004332 (EC: EXP); GO_0004332 (EC: IDA, PMID: 10625657); GO_0005515 (EC: IPI, PMID: 18000879); GO_0005815 (EC: IDA, PMID: 18000879); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0006000 (EC: IMP, PMID: 3383242); GO_0006001 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006096 (EC: IDA, PMID: 10625657); GO_0006096 (EC: IEA); GO_0006096 (EC: TAS); GO_0006116 (EC: IDA, PMID: 17576770); GO_0008092 (EC: IDA, PMID: 9244396); GO_0030388 (EC: IDA, PMID: 10625657); GO_0032781 (EC: IGI, PMID: 17576770); GO_0034451 (EC: IDA, PMID: 18000879); GO_0042802 (EC: IPI, PMID: 10625657); GO_0044281 (EC: TAS); GO_0051117 (EC: IDA, PMID: 17576770); GO_0070061 (EC: IMP, PMID: 10625657); GO_0070072 (EC: IGI, PMID: 17576770)
PMID: 1967768; 2336380; 2410860; 2649152; 2830249; 3000275; 3016456; 3383242; 6548561; 6585824; 6689266; 7717389; 8162030; 8299883; 8535439; 9244396; 10024431; 10625657; 10970798; 11241348; 11399750; 11679716; 11752456; 12205126; 12417303; 12464284; 12477932; 14966907; 15063762; 15532022; 15880727; 16406649; 17292585; 17457694; 17576770; 17955389; 18000879; 18029348; 18541450; 18700007; 19817957; 20033295; 20162364; 20848650; 20882353; 21166391; 21832049; 21890473; 21963094; 21987572; 21988832; 22001757; 22505724; 22911800
aldolase B, fructose-bisphosphate
Ensembl:ENSG00000136872
HGNC:417
HPRD:01972
MIM:612724
Vega:OTTHUMG00000020378
Other designations: aldolase 2|aldolase B, fructose-bisphosphatase|fructose-bisphosphate aldolase B|liver-type aldolase
ALDOB
Bin Zhao, Yue Liu, Oliver He
ALS9
HEL168
RAA1
RNASE4
RNASE5
WEB: http://www.ncbi.nlm.nih.gov/gene
ANG
angiogenin, ribonuclease, RNase A family, 5
283
14q11.1-q11.2
9606
14
Official from a nomenclature committee
GO_0001525 (EC: IDA, PMID: 8448182); GO_0001525 (EC: IMP, PMID: 17125737); GO_0001525 (EC: TAS, PMID: 16567967); GO_0001541 (EC: NAS, PMID: 12770725); GO_0001556 (EC: NAS, PMID: 11438326); GO_0001666 (EC: IDA, PMID: 10999833); GO_0001666 (EC: NAS, PMID: 15776477); GO_0001890 (EC: NAS, PMID: 11984825); GO_0001938 (EC: IDA, PMID: 9122172); GO_0003677 (EC: IC, PMID: 10649442); GO_0003779 (EC: IDA, PMID: 11782452); GO_0004519 (EC: TAS, PMID: 10103013); GO_0004540 (EC: IDA, PMID: 2424496); GO_0005102 (EC: IDA, PMID: 9122172); GO_0005507 (EC: IDA, PMID: 9245697); GO_0005515 (EC: IPI, PMID: 10413501); GO_0005605 (EC: IDA, PMID: 15166501); GO_0005615 (EC: IDA, PMID: 16461950); GO_0005634 (EC: IDA, PMID: 10649442); GO_0005730 (EC: ISS); GO_0006651 (EC: IDA, PMID: 2457905); GO_0007154 (EC: NAS, PMID: 10103013); GO_0007202 (EC: IMP, PMID: 2457905); GO_0008201 (EC: IDA, PMID: 10103013); GO_0008219 (EC: IEA); GO_0009303 (EC: IMP, PMID: 15735021); GO_0009725 (EC: IDA, PMID: 10999833); GO_0016477 (EC: IMP, PMID: 17125737); GO_0016892 (EC: IEA); GO_0017148 (EC: IEA); GO_0019843 (EC: TAS, PMID: 2457905); GO_0030041 (EC: ISS); GO_0030426 (EC: ISS); GO_0032148 (EC: IMP, PMID: 17125737); GO_0032311 (EC: IPI, PMID: 3470787); GO_0032431 (EC: IMP, PMID: 2646638); GO_0042277 (EC: IDA, PMID: 11782452); GO_0042327 (EC: IDA, PMID: 17125737); GO_0042592 (EC: NAS, PMID: 15166501); GO_0043025 (EC: ISS); GO_0048662 (EC: IDA, PMID: 10103013); GO_0050714 (EC: IDA, PMID: 2646638); GO_0050714 (EC: ISS); GO_0090305 (EC: TAS, PMID: 10103013); GO_0090501 (EC: IDA, PMID: 2424496)
PMID: 1400510; 1978563; 2276743; 2424496; 2440105; 2457905; 2479414; 2646638; 2730651; 2742853; 2866794; 2866795; 3470787; 3619929; 3663649; 7679494; 7945327; 8127865; 8159679; 8448182; 9122172; 9245697; 9311977; 9461294; 9707554; 9918722; 10103013; 10413501; 10648935; 10649442; 10999833; 11374889; 11438326; 11468363; 11751393; 11752456; 11782452; 11847008; 11851402; 11919285; 11984825; 12168899; 12209593; 12477932; 12515546; 12705339; 12770725; 12842050; 14593238; 14671622; 14756559; 15064314; 15067362; 15128420; 15166501; 15182336; 15236995; 15489334; 15557516; 15558023; 15735021; 15737636; 15776477; 15979542; 16169070; 16322296; 16461950; 16490744; 16567967; 16712791; 16937522; 17113198; 17125737; 17207965; 17462671; 17703939; 17886298; 17900154; 17991437; 18087731; 18636464; 18808740; 18852347; 18936943; 18955785; 19158252; 19160530; 19253715; 19262607; 19287993; 19332886; 19363631; 19423182; 19625371; 19631914; 20045391; 20105109; 20137109; 20174961; 20301623; 20452482; 20472325; 20484129; 20577002; 20629092; 20673868; 20838751; 20923443; 20952631; 20955379; 21085671; 21091473; 21103661; 21154263; 21209106; 21364907; 21375772; 21439815; 21528671; 21539846; 21621297; 21711968; 21778318; 21800332; 21808991; 21919032; 21988832; 22148849; 22190368; 22194915; 22266868; 22292798; 22292843; 22372545; 22384259; 22438557; 22449478; 22526325; 22633874; 22694909; 22940420; 23229115; 23231972; 23351638; 23379493; 23409128; 23665167; 23989187; 24122807; 24337645
angiogenin, ribonuclease, RNase A family, 5
Ensembl:ENSG00000214274
HGNC:483
HPRD:00105
MIM:105850
Vega:OTTHUMG00000029576
Other designations: RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
ANG
Bin Zhao, Yue Liu, Oliver He
AGP1
AGPT
ANG1
WEB: http://www.ncbi.nlm.nih.gov/gene
ANGPT1
angiopoietin 1
284
8q23.1
9606
8
GO_0001701 (EC: IEA); GO_0001936 (EC: IDA, Qualifier: NOT, PMID:8980223); GO_0002040 (EC: IDA, PMID:10218485); GO_0002092 (EC: IDA, PMID:19424712); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID:10218485); GO_0005886 (EC: IDA, PMID:19424712); GO_0005902 (EC: IDA, PMID:19424712); GO_0007162 (EC: IDA, PMID:19674970); GO_0007171 (EC: IDA, PMID:19424712); GO_0007596 (EC: TAS); GO_0010595 (EC: IDA, PMID:12958144); GO_0014068 (EC: IEA); GO_0014842 (EC: IDA, PMID:19733541); GO_0030097 (EC: IEA); GO_0030154 (EC: IEA); GO_0030210 (EC: IDA, PMID:19297368); GO_0030971 (EC: IPI, PMID:19922791); GO_0031398 (EC: IDA, PMID:19689429); GO_0031589 (EC: IEA); GO_0033138 (EC: IEA); GO_0034394 (EC: IDA, PMID:19615361); GO_0043066 (EC: IDA, PMID:10218485); GO_0043116 (EC: IDA, PMID:14978158); GO_0043524 (EC: IEA); GO_0043536 (EC: IDA, PMID:9660821); GO_0045121 (EC: IDA, PMID:19615361); GO_0045785 (EC: IEA); GO_0048014 (EC: IDA, PMID:19689429); GO_0050731 (EC: IDA, PMID:15851516); GO_0050900 (EC: TAS); GO_0050918 (EC: IDA, PMID:9660821); GO_0051897 (EC: IDA, PMID:18425120); GO_0070062 (EC: IDA, PMID:19199708); GO_0070374 (EC: IDA, PMID:18425120); GO_0072012 (EC: ISS); GO_2000352 (EC: IDA, PMID:19674970)
PMID:7584026; 7584028; 7642106; 8980223; 8980224; 9204896; 9525952; 9545648; 9560344; 9660821; 9723709; 10051567; 10218485; 10343124; 10514510; 10706866; 10766762; 10854239; 10944458; 11165944; 11729102; 11776343; 11827452; 11856872; 11870550; 11891175; 11967990; 12138242; 12168954; 12213874; 12239588; 12243755; 12402160; 12427764; 12477932; 12612904; 12649156; 12717391; 12810673; 12816861; 12890486; 12958144; 12958167; 14561809; 14597243; 14665640; 14672554; 14715662; 14749497; 14978158; 14991531; 15001532; 15019820; 15094228; 15161644; 15198927; 15213103; 15242771; 15284220; 15381091; 15453096; 15498854; 15542434; 15562207; 15692086; 15694363; 15746084; 15769741; 15781448; 15823283; 15851516; 15892598; 16000309; 16020388; 16049136; 16229183; 16354591; 16547766; 16614513; 16645159; 16690881; 16723371; 16803467; 16830384; 16917117; 16956819; 17039426; 17168735; 17322632; 17341311; 17466926; 17525262; 17558601; 17562701; 17603084; 17637706; 17724803; 17728252; 17785951; 17803352; 17943167; 18035072; 18080866; 18092380; 18199826; 18269030; 18310225; 18326231; 18330951; 18382887; 18425120; 18664247; 18675456; 18807212; 18823985; 18991494; 18996102; 19010534; 19028450; 19082480; 19082594; 19086654; 19127216; 19148554; 19199708; 19223473; 19297368; 19300530; 19301945; 19322669; 19339077; 19351722; 19424712; 19460752; 19476937; 19478794; 19487284; 19543148; 19567053; 19615361; 19674970; 19689429; 19733541; 19815705; 19875484; 19916173; 19919521; 19922791; 19954476; 20036815; 20056911; 20072144; 20098680; 20099495; 20185425; 20208992; 20346360; 20378606; 20471887; 20554518; 20602615; 20629092; 20696814; 20863203; 21042788; 21140268; 21168819; 21179479; 21212269; 21273558; 21300047; 21380565; 21400522; 21660578; 21672190; 21710361; 21778249; 21849906; 21858121; 21878936; 21884468; 21885850; 21905000; 21905955; 21906428; 21948244; 21963094; 22000910; 22015631; 22033412; 22095586; 22143796; 22205728; 22229541; 22235284; 22334788; 22391155; 22449617; 22483377; 22496856; 22583143; 22642477; 22867989; 22901561; 22949515; 23024612; 23099117; 23123737; 23190105; 23232696; 23288163; 23302768; 23382691; 23504320; 23592718; 23652985; 23686433; 23770419; 23785018; 23835996; 23840065; 24010773
angiopoietin 1
Ensembl:ENSG00000154188
HGNC:484
HPRD:03392
MIM:601667
Vega:OTTHUMG00000164812
Other designations: ANG-1|angiopoietin-1
ANGPT1
Bin Zhao, Yue Liu, Oliver He
AGPT2
ANG2
WEB: http://www.ncbi.nlm.nih.gov/gene
ANGPT2
angiopoietin 2
285
8p23.1
9606
8
GO_0001525 (EC: IEA); GO_0001666 (EC: IEA); GO_0005102 (EC: TAS, PMID:10766762); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID:9660821); GO_0005634 (EC: IEA); GO_0005886 (EC: IEA); GO_0007165 (EC: TAS, PMID:10766762); GO_0007281 (EC: IEA); GO_0007596 (EC: TAS); GO_0009314 (EC: IEA); GO_0009612 (EC: IEA); GO_0009749 (EC: IEA); GO_0010812 (EC: IEA); GO_0014070 (EC: IEA); GO_0014823 (EC: IEA); GO_0016525 (EC: IEA); GO_0030971 (EC: IPI, PMID:19922791); GO_0031100 (EC: IEA); GO_0042995 (EC: IEA); GO_0043537 (EC: IDA, PMID:9660821); GO_0045766 (EC: IEA); GO_0046872 (EC: IEA); GO_0048014 (EC: IDA, PMID:19922791); GO_0050900 (EC: TAS); GO_0050928 (EC: IDA, PMID:9660821); GO_0060135 (EC: IEA); GO_0071363 (EC: IEA); GO_0072012 (EC: ISS)
PMID:8125298; 9204896; 9545648; 9660821; 9723709; 9927494; 10051567; 10343124; 10514510; 10766762; 10964717; 11447223; 11578860; 11856872; 11861279; 12138242; 12176040; 12213874; 12427764; 12477932; 12612904; 12717391; 12810677; 12861074; 14507641; 14556828; 14568550; 14702352; 14726409; 14767538; 14768007; 14976056; 14991531; 15002056; 15003510; 15094228; 15112366; 15127326; 15161644; 15198927; 15213103; 15284088; 15284220; 15375511; 15489334; 15498854; 15542434; 15562207; 15642468; 15694966; 15734895; 15743799; 15769741; 15823283; 15893672; 16009172; 16020388; 16129411; 16182107; 16229183; 16242072; 16290311; 16338068; 16344560; 16417407; 16424009; 16458662; 16465407; 16525658; 16538528; 16614513; 16629644; 16690881; 16714355; 16723371; 16790091; 16803467; 16830384; 16877277; 16956819; 16978237; 16978614; 17003480; 17030814; 17141400; 17167981; 17200776; 17258205; 17287278; 17322632; 17341311; 17361220; 17395886; 17409768; 17505039; 17513791; 17558601; 17601353; 17630849; 17673702; 17704802; 17724803; 17785951; 17828495; 17904634; 17928052; 17931370; 17943167; 18006475; 18092380; 18182823; 18269030; 18310225; 18382887; 18483397; 18516587; 18541195; 18564921; 18568888; 18644593; 18664247; 18675456; 18720385; 18727515; 18791490; 18807212; 18952457; 18957536; 18991494; 18996102; 19010534; 19018553; 19082594; 19086654; 19102939; 19112163; 19164323; 19223473; 19226440; 19228739; 19271210; 19300530; 19339208; 19341361; 19351722; 19403561; 19435449; 19438587; 19476937; 19478794; 19499513; 19502452; 19539650; 19543148; 19551369; 19567053; 19616847; 19728062; 19815705; 19875484; 19913849; 19922791; 19954476; 20067780; 20068079; 20072144; 20088942; 20099495; 20179005; 20208992; 20213583; 20348331; 20359117; 20379614; 20382847; 20452482; 20482750; 20501615; 20519501; 20562294; 20583134; 20599737; 20629092; 20670479; 20673868; 20696814; 20806109; 20863203; 21042788; 21081932; 21119365; 21131273; 21143700; 21149250; 21163858; 21168819; 21179479; 21248670; 21257790; 21269615; 21300047; 21337734; 21368233; 21380565; 21400522; 21439064; 21450636; 21565611; 21575447; 21576085; 21603628; 21643812; 21672190; 21680733; 21685330; 21750433; 21762624; 21778249; 21809353; 21849906; 21851472; 21858121; 21884204; 21884468; 21900206; 21948244; 21956768; 21963094; 22000910; 22015631; 22095586; 22142364; 22182412; 22229541; 22279570; 22289349; 22311497; 22327175; 22342979; 22449617; 22483377; 22585576; 22640261; 22642477; 22659681; 22728324; 22730375; 22750392; 22770562; 22777681; 22949515; 22989097; 22995870; 23024612; 23099117; 23123737; 23149917; 23174599; 23190105; 23190218; 23232696; 23284823; 23302768; 23305976; 23409162; 23419030; 23421785; 23467610; 23503679; 23536671; 23587231; 23649549; 23652985; 23758184; 23785018; 23803577; 23826161; 23835996; 23899926; 24106271; 24355874; 24373251; 24421076
angiopoietin 2
Ensembl:ENSG00000091879
HGNC:485
HPRD:03563
MIM:601922
Vega:OTTHUMG00000090365
Other designations: ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
ANGPT2
Bin Zhao, Yue Liu, Oliver He
1
AAC1
ANT
ANT 1
ANT1
MTDPS12
PEO2
PEO3
T1
WEB: http://www.ncbi.nlm.nih.gov/gene
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
291
4q35
9606
4
Official from a nomenclature committee
GO_0000002 (EC: TAS, PMID: 10926541); GO_0005515 (EC: IPI, PMID: 16507998); GO_0005739 (EC: IDA); GO_0005743 (EC: TAS); GO_0005887 (EC: TAS, PMID: 2823266); GO_0006091 (EC: TAS, PMID: 2823266); GO_0006112 (EC: TAS); GO_0006810 (EC: TAS, PMID: 2823266); GO_0008637 (EC: IEA); GO_0015207 (EC: TAS, PMID: 2823266); GO_0015853 (EC: TAS, PMID: 2823266); GO_0016032 (EC: TAS); GO_0044281 (EC: TAS); GO_0050796 (EC: TAS); GO_0060546 (EC: IMP, PMID: 16507998)
PMID: 1582253; 2541251; 2547778; 2823266; 2829183; 8103757; 8479824; 8619474; 8644740; 9110174; 9748162; 9874241; 10364542; 10620603; 10926541; 11175251; 11181702; 11193032; 11287411; 11756592; 11756613; 11809823; 12039962; 12112115; 12140186; 12149099; 12450408; 12477932; 12565915; 12663490; 12707443; 12750393; 12750404; 14729611; 15033717; 15142377; 15231833; 15489334; 15551024; 15638722; 15725353; 15792871; 15817944; 15832179; 16020522; 16107323; 16120388; 16155110; 16226712; 16236267; 16354571; 16429131; 16492162; 16507998; 16511342; 16556444; 16887100; 17203973; 17328670; 17331040; 17420318; 17586316; 17586317; 18094160; 18504126; 18575922; 18781797; 18852887; 19149577; 19232058; 19275580; 19275583; 19275588; 19425506; 19840444; 19965780; 20007455; 20012529; 20160640; 20181062; 20186120; 20504995; 20528917; 20698827; 20843780; 20877624; 20972266; 21139048; 21145461; 21196320; 21318276; 21319273; 21586654; 21890473; 21906983; 21918813; 21963094; 22178446; 22187496; 22350218; 22354994; 22797925; 22939629; 23000965; 23246001; 23266187; 23401503; 23464991; 24244333
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Ensembl:ENSG00000151729
HGNC:10990
HPRD:00058
MIM:103220
Vega:OTTHUMG00000134299
Other designations: ADP,ATP carrier protein 1|ADP,ATP carrier protein, heart/skeletal muscle|ADP/ATP translocase 1|adenine nucleotide translocator 1 (skeletal muscle)|heart/skeletal muscle ATP/ADP translocator|solute carrier family 25 member 4
SLC25A4
Bin Zhao, Yue Liu, Oliver He
APAF-1
CED4
WEB: http://www.ncbi.nlm.nih.gov/gene
APAF1
apoptotic peptidase activating factor 1
317
12q23
9606
12
Official from a nomenclature committee
GO_0000166 (EC: TAS, PMID: 10383829); GO_0001843 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10206961); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005829 (EC: TAS); GO_0006309 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IDA); GO_0006952 (EC: IEA); GO_0007399 (EC: TAS, PMID: 9753320); GO_0008635 (EC: IDA, PMID: 9267021); GO_0008635 (EC: TAS); GO_0008656 (EC: NAS, PMID: 15009102); GO_0030900 (EC: IEA); GO_0042802 (EC: IEA); GO_0042981 (EC: TAS, PMID: 10441496); GO_0043065 (EC: TAS, PMID: 18309324); GO_0043293 (EC: IDA); GO_0043293 (EC: TAS, PMID: 18309324); GO_0043531 (EC: IEA); GO_0051402 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072432 (EC: TAS, PMID: 18309324); GO_0097193 (EC: TAS, PMID: 18309324); GO_2001235 (EC: IEA)
PMID: 9267021; 9390557; 9455477; 9488720; 9539746; 9651578; 9753320; 9829980; 9837928; 9878060; 9922454; 10206961; 10322433; 10364241; 10376594; 10383829; 10393175; 10441496; 10486928; 10543941; 10578182; 10702682; 10722681; 10764728; 10934467; 10949025; 11113115; 11230124; 11242052; 11389439; 11457460; 11550094; 11864614; 12021264; 12147322; 12149244; 12168954; 12477932; 12549820; 12615903; 12637514; 12804598; 12963020; 14566819; 14747474; 14993223; 15001356; 15009102; 15026369; 15033720; 15103018; 15262985; 15305193; 15378005; 15590702; 15649154; 15692060; 15703181; 15735003; 15829969; 15832174; 15832175; 15863166; 15972851; 16046141; 16098052; 16231040; 16232302; 16331630; 16420245; 16595687; 16951219; 16979168; 17081983; 17133271; 17274640; 17348858; 17361096; 17418785; 17534194; 17541304; 17603079; 17876870; 17882496; 17885667; 18029348; 18042457; 18093951; 18309324; 18373966; 18439902; 18587251; 18676680; 18719738; 18834886; 19056867; 19058789; 19074885; 19141860; 19170196; 19238172; 19322201; 19455599; 19603830; 19625176; 19662370; 19675677; 19692168; 19698783; 19801675; 19809088; 19913121; 20345447; 20379614; 20453000; 20628086; 20959405; 20977544; 21104989; 21139048; 21297999; 21528061; 21659556; 21890473; 21906983; 21922274; 22101335; 22143029; 22246185; 22335196; 22632162; 22996741; 23085065; 23207240; 23326121; 23521171; 23822711
apoptotic peptidase activating factor 1
Ensembl:ENSG00000120868
HGNC:576
HPRD:03755
MIM:602233
Vega:OTTHUMG00000170214
Other designations: apoptotic protease-activating factor 1
APAF1
Bin Zhao, Yue Liu, Oliver He
HEL-S-92n
PTX2
SAP
WEB: http://www.ncbi.nlm.nih.gov/gene
APCS
amyloid P component, serum
325
1q21-q23
9606
1
Official from a nomenclature committee
GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0006457 (EC: TAS, PMID: 10812074); GO_0006953 (EC: TAS, PMID: 2987268); GO_0031012 (EC: IDA, Qualifier: colocalizes_with); GO_0043234 (EC: IEA); GO_0046872 (EC: IEA); GO_0051082 (EC: TAS, PMID: 10812074); GO_0051131 (EC: TAS, PMID: 10972085); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072562 (EC: IDA)
PMID: 81686; 1477104; 1602151; 2987268; 3029048; 3172210; 3211159; 3759147; 3915434; 4055725; 7592941; 8114934; 8144569; 8202534; 8417122; 8662978; 8999915; 9217261; 10631319; 10812074; 10972085; 11359830; 11441067; 11984001; 12015594; 12100475; 12126626; 12432394; 12477932; 12528126; 12767937; 14500533; 14519527; 14607961; 14718574; 15031287; 15174148; 15489334; 15649951; 15837583; 16335952; 16380821; 16643876; 16710414; 16784490; 17138933; 17530641; 17630380; 17676666; 18174230; 18624398; 19011614; 19052452; 19056867; 19948975; 20189569; 20237496; 20300636; 20930309; 20932823; 21044893; 21106539; 21223953; 21278351; 21360619; 21900206; 21988832; 22205573; 22396542; 22493081; 22867744; 22939635; 23385359; 23390551; 23423137; 23527487; 23544079; 23600950; 23966633
amyloid P component, serum
Ensembl:ENSG00000132703
HGNC:584
HPRD:00101
MIM:104770
Vega:OTTHUMG00000022741
Other designations: 9.5S alpha-1-glycoprotein|epididymis secretory sperm binding protein Li 92n|pentaxin-related|serum amyloid P-component
APCS
Bin Zhao, Yue Liu, Oliver He
AD2
LDLCQ5
LPG
WEB: http://www.ncbi.nlm.nih.gov/gene
APOE
apolipoprotein E
348
19q13.2
9606
19
Official from a nomenclature committee
GO_0000302 (EC: NAS, PMID: 11743999); GO_0001523 (EC: TAS); GO_0001540 (EC: IDA, PMID: 11305869); GO_0001937 (EC: IDA, PMID: 9685360); GO_0002021 (EC: IEA); GO_0005319 (EC: IDA, PMID: 17305370); GO_0005515 (EC: IPI, PMID: 12950167); GO_0005543 (EC: IDA, PMID: 4066713); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005737 (EC: NAS, PMID: 8083695); GO_0005737 (EC: TAS, PMID: 9622609); GO_0005769 (EC: TAS); GO_0005770 (EC: IEA); GO_0005794 (EC: IEA); GO_0005886 (EC: TAS); GO_0006641 (EC: IDA, PMID: 9649566); GO_0006641 (EC: IMP, PMID: 3771793); GO_0006707 (EC: IEA); GO_0006874 (EC: IEA); GO_0006898 (EC: IDA, PMID: 1917954); GO_0007010 (EC: TAS, PMID: 9622609); GO_0007186 (EC: IDA, PMID: 16443932); GO_0007263 (EC: IDA, PMID: 8995232); GO_0007271 (EC: TAS, PMID: 9622609); GO_0007568 (EC: IEA); GO_0007603 (EC: TAS); GO_0008201 (EC: IDA, PMID: 2745454); GO_0008203 (EC: IDA, PMID: 9649566); GO_0008203 (EC: IMP, PMID: 3771793); GO_0008219 (EC: IEA); GO_0008289 (EC: IDA, PMID: 4066713); GO_0010544 (EC: IDA, PMID: 8995232); GO_0010873 (EC: IDA, PMID: 15654758); GO_0010875 (EC: IDA, PMID: 14754908); GO_0010875 (EC: IGI, PMID: 12401887); GO_0014012 (EC: IEA); GO_0016209 (EC: IDA, PMID: 9685360); GO_0017127 (EC: IEA); GO_0019934 (EC: IDA, PMID: 8995232); GO_0030195 (EC: IDA, PMID: 8995232); GO_0030425 (EC: NAS, PMID: 8083695); GO_0030516 (EC: TAS, PMID: 9622609); GO_0030828 (EC: IDA, PMID: 8995232); GO_0031232 (EC: IEA); GO_0032489 (EC: IDA, PMID: 16443932); GO_0032526 (EC: IEA); GO_0032805 (EC: IDA, PMID: 15950758); GO_0032868 (EC: IEA); GO_0033344 (EC: IDA, PMID: 11162594); GO_0033700 (EC: IDA, PMID: 11162594); GO_0034361 (EC: IDA, PMID: 17154273); GO_0034362 (EC: IDA, PMID: 8245722); GO_0034363 (EC: IDA, PMID: 17336988); GO_0034364 (EC: IDA, PMID: 210174); GO_0034372 (EC: IDA, PMID: 15654758); GO_0034372 (EC: IGI, PMID: 12401887); GO_0034374 (EC: IEA); GO_0034375 (EC: IGI, PMID: 12401887); GO_0034380 (EC: IDA, PMID: 17305370); GO_0034382 (EC: IMP, PMID: 7175379); GO_0034384 (EC: IDA, PMID: 210175); GO_0034447 (EC: IDA, PMID: 1917954); GO_0034447 (EC: IMP, PMID: 9649566); GO_0042157 (EC: TAS); GO_0042158 (EC: IEA); GO_0042159 (EC: IEA); GO_0042311 (EC: IEA); GO_0042627 (EC: IDA, PMID: 16935699); GO_0042632 (EC: IDA, PMID: 9649566); GO_0042802 (EC: IDA, PMID: 4066713); GO_0042803 (EC: IPI, PMID: 8245722); GO_0043025 (EC: NAS, PMID: 8083695); GO_0043407 (EC: IDA, PMID: 9685360); GO_0043524 (EC: IEA); GO_0043537 (EC: IDA, PMID: 9685360); GO_0043691 (EC: IDA, PMID: 8127890); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0045541 (EC: IDA, PMID: 1917954); GO_0045773 (EC: IEA); GO_0046848 (EC: IEA); GO_0046907 (EC: TAS, PMID: 9622609); GO_0046911 (EC: IDA, PMID: 9685360); GO_0048156 (EC: IPI, PMID: 7566652); GO_0048168 (EC: TAS, PMID: 9622609); GO_0048709 (EC: IEA); GO_0048844 (EC: IEA); GO_0050728 (EC: IC, PMID: 8995232); GO_0050750 (EC: IDA, PMID: 210175); GO_0050750 (EC: IPI, PMID: 17326667); GO_0051000 (EC: IDA, PMID: 8995232); GO_0051044 (EC: IDA, PMID: 15950758); GO_0051651 (EC: IEA); GO_0060228 (EC: IDA, PMID: 15654758); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070326 (EC: IDA, PMID: 1384047); GO_0070326 (EC: IPI, PMID: 12950167); GO_0071347 (EC: IEA); GO_0071363 (EC: IEA); GO_0071397 (EC: IEA); GO_0071682 (EC: TAS); GO_0071813 (EC: IEA); GO_0072562 (EC: IDA)
PMID: 210174; 210175; 759055; 1356443; 1360898; 1361196; 1384047; 1617762; 1674745; 1713245; 1730728; 1917954; 2063194; 2101409; 2313204; 2341812; 2470732; 2498325; 2539388; 2556398; 2738044; 2745454; 2760009; 2779654; 2851587; 2987927; 2992507; 3038959; 3243553; 3283935; 3771793; 3922972; 3947350; 4066713; 4345202; 6199196; 6289314; 6323533; 6325438; 6327682; 6897404; 7068630; 7175379; 7263700; 7498414; 7566652; 7581381; 7586659; 7635945; 7761390; 7768901; 7797576; 7833947; 7972031; 8063017; 8083695; 8127890; 8245722; 8287539; 8300609; 8346443; 8488843; 8620924; 8624078; 8626535; 8756331; 8995232; 9012418; 9147408; 9218423; 9236223; 9360638; 9512010; 9622609; 9649566; 9685360; 9831625; 9869645; 9931331; 10520737; 10559559; 10662539; 10850798; 10962542; 10993992; 11030801; 11032626; 11033977; 11042151; 11055796; 11058710; 11060506; 11061249; 11063158; 11064931; 11072138; 11074789; 11076057; 11079660; 11095479; 11095526; 11096027; 11099722; 11100124; 11106322; 11109009; 11110974; 11113217; 11118024; 11118260; 11118404; 11118932; 11119301; 11121165; 11125748; 11126401; 11129109; 11129992; 11140838; 11140944; 11141572; 11143490; 11152862; 11153762; 11156623; 11157409; 11160955; 11162594; 11166913; 11166947; 11171287; 11171894; 11172628; 11173876; 11173877; 11173882; 11176958; 11177205; 11182472; 11204323; 11218879; 11229422; 11231028; 11236867; 11244490; 11254923; 11256794; 11257253; 11257255; 11259129; 11269459; 11269753; 11273849; 11273909; 11277566; 11280044; 11281447; 11281508; 11285089; 11295126; 11299424; 11302074; 11303757; 11305732; 11305851; 11305869; 11311499; 11315514; 11320185; 11326299; 11328206; 11332642; 11334266; 11334897; 11340230; 11341749; 11343612; 11343837; 11351136; 11354629; 11355019; 11357958; 11359065; 11360807; 11376902; 11378846; 11383910; 11388660; 11398147; 11401504; 11401610; 11412677; 11420577; 11420784; 11421127; 11421132; 11421580; 11422615; 11431078; 11434425; 11445282; 11445633; 11454010; 11456487; 11458997; 11463413; 11471927; 11472462; 11474482; 11475012; 11477126; 11482130; 11484169; 11484172; 11487204; 11494308; 11495026; 11495633; 11500190; 11501342; 11502364; 11504565; 11509287; 11512679; 11516561; 11526473; 11535238; 11546879; 11552016; 11553047; 11558492; 11559372; 11560764; 11563433; 11568917; 11571342; 11574101; 11580926; 11585357; 11589721; 11592046; 11592592; 11665324; 11673588; 11673590; 11676289; 11676291; 11684342; 11684904; 11698154; 11701639; 11702052; 11711204; 11714857; 11714860; 11720484; 11721184; 11722155; 11723294; 11730829; 11738493; 11739991; 11740190; 11743999; 11748362; 11755017; 11755252; 11756600; 11769625; 11769703; 11769724; 11775232; 11780357; 11780396; 11784357; 11784371; 11788473; 11788960; 11791620; 11793025; 11798896; 11803456; 11804199; 11804704; 11805010; 11807891; 11807900; 11814460; 11820771; 11823668; 11830396; 11834531; 11836653; 11840773; 11840804; 11844848; 11849659; 11849755; 11857554; 11860878; 11860925; 11862316; 11863377; 11873594; 11879722; 11882334; 11882335; 11882522; 11882743; 11882744; 11884656; 11884660; 11885754; 11889238; 11890580; 11893833; 11901276; 11903341; 11903399; 11904138; 11910554; 11912196; 11920850; 11921083; 11922198; 11931575; 11931577; 11936239; 11936240; 11939894; 11939896; 11940690; 11940706; 11949718; 11950276; 11952809; 11954859; 11959333; 11966948; 11971052; 11971084; 11981126; 11983298; 11983299; 11984219; 11987699; 11988589; 11988615; 11990879; 11992263; 11992569; 12000192; 12003251; 12003753; 12006218; 12006397; 12007670; 12009520; 12015813; 12015945; 12019933; 12023414; 12023438; 12028246; 12028507; 12030385; 12032151; 12036962; 12040140; 12042130; 12042142; 12042316; 12042669; 12042894; 12044628; 12049183; 12057992; 12059987; 12061406; 12069854; 12071547; 12074828; 12075916; 12077730; 12082592; 12086087; 12086099; 12086229; 12087994; 12093429; 12094820; 12095653; 12105308; 12107813; 12112161; 12113906; 12116196; 12116231; 12117364; 12118856; 12123486; 12123862; 12128082; 12133811; 12135350; 12138091; 12142731; 12143056; 12145452; 12148096; 12160362; 12164879; 12165926; 12166499; 12167620; 12167762; 12168771; 12175441; 12185156; 12185856; 12192621; 12192623; 12195533; 12196500; 12198535; 12200750; 12205106; 12205649; 12210279; 12213685; 12213863; 12214086; 12220441; 12221169; 12226739; 12231459; 12232782; 12243365; 12269825; 12270650; 12297572; 12325053; 12359980; 12364385; 12370113; 12379839; 12393935; 12394840; 12397634; 12398946; 12401887; 12405546; 12406021; 12411758; 12411763; 12413003; 12414984; 12417285; 12417379; 12417380; 12417381; 12417453; 12419494; 12433268; 12434887; 12438469; 12438664; 12439225; 12439291; 12444925; 12444983; 12454737; 12457072; 12459519; 12461692; 12471457; 12473860; 12475089; 12477932; 12480082; 12480755; 12486288; 12495080; 12495081; 12495082; 12497107; 12497631; 12498968; 12499050; 12500534; 12502505; 12507914; 12512226; 12518038; 12521230; 12527542; 12529167; 12533090; 12535745; 12536572; 12544508; 12552038; 12552039; 12556576; 12558712; 12561220; 12566177; 12567264; 12573381; 12576523; 12579507; 12580702; 12580859; 12581338; 12584430; 12587416; 12588864; 12588928; 12593496; 12593615; 12595762; 12600078; 12604387; 12605101; 12618306; 12624708; 12631135; 12632068; 12634288; 12636937; 12637699; 12638732; 12644914; 12647263; 12648751; 12649507; 12654974; 12656452; 12657090; 12657895; 12658367; 12658375; 12662159; 12666069; 12668918; 12669678; 12675686; 12677480; 12678662; 12682309; 12691171; 12701674; 12706318; 12707932; 12707937; 12707938; 12714797; 12715012; 12719629; 12722493; 12729008; 12736093; 12736801; 12739024; 12742846; 12746397; 12749052; 12753088; 12754278; 12769659; 12771320; 12774036; 12778454; 12778455; 12782148; 12782337; 12782964; 12787320; 12788901; 12794386; 12796755; 12798568; 12799433; 12809979; 12810154; 12810485; 12810796; 12810820; 12811635; 12812866; 12815750; 12817590; 12818409; 12818414; 12821037; 12821754; 12833399; 12833577; 12837283; 12837518; 12841538; 12845379; 12850485; 12857755; 12860263; 12864777; 12871600; 12873586; 12876232; 12876259; 12880539; 12881819; 12882872; 12883119; 12886039; 12889841; 12897404; 12899198; 12901521; 12901781; 12905860; 12915220; 12915699; 12917433; 12919138; 12920078; 12923233; 12923801; 12926843; 12928055; 12928512; 12930057; 12930912; 12935416; 12939405; 12940632; 12940873; 12946561; 12950167; 12951205; 12954489; 12957508; 12959500; 12960780; 12962909; 12963757; 12963763; 12964943; 12966036; 13129656; 13680463; 14500990; 14501969; 14504972; 14506116; 14512205; 14512206; 14512715; 14520543; 14523627; 14523999; 14530190; 14563588; 14566994; 14569045; 14570844; 14572957; 14583365; 14585838; 14587032; 14588111; 14593964; 14594022; 14596852; 14609807; 14612205; 14614898; 14615042; 14615272; 14624406; 14625044; 14638877; 14639046; 14646029; 14650352; 14656220; 14659862; 14672279; 14674716; 14675603; 14677138; 14680604; 14681851; 14681915; 14687732; 14688411; 14688681; 14694215; 14695944; 14695947; 14698449; 14705977; 14706682; 14709760; 14711551; 14718482; 14718574; 14720419; 14726545; 14734213; 14739281; 14739533; 14741429; 14743603; 14746139; 14754908; 14755445; 14757931; 14759632; 14763959; 14763962; 14766005; 14767871; 14769392; 14769603; 14966149; 14982742; 14986172; 14986436; 14989602; 14997020; 15000890; 15003956; 15007140; 15014128; 15018693; 15019539; 15023809; 15026113; 15031162; 15033184; 15034781; 15036621; 15045621; 15048651; 15048896; 15048897; 15050032; 15060087; 15060098; 15060316; 15066991; 15073531; 15076187; 15077085; 15079025; 15079806; 15084782; 15084783; 15090300; 15090562; 15093983; 15096402; 15098180; 15099158; 15102883; 15106838; 15109264; 15111581; 15111582; 15123333; 15123334; 15123497; 15124760; 15129156; 15131109; 15133863; 15135251; 15136700; 15138483; 15142050; 15144588; 15145993; 15146195; 15147594; 15152345; 15157846; 15159498; 15159600; 15159602; 15161645; 15161775; 15165699; 15167692; 15174051; 15174235; 15181244; 15181247; 15181372; 15181744; 15183747; 15184597; 15184600; 15184602; 15184605; 15184629; 15186949; 15186962; 15187200; 15193960; 15201366; 15201477; 15202770; 15202789; 15202933; 15207528; 15207892; 15210882; 15211066; 15211070; 15212826; 15213448; 15217762; 15220465; 15221639; 15222689; 15222690; 15222832; 15223114; 15224026; 15226466; 15227722; 15236771; 15239601; 15245790; 15246985; 15246987; 15247087; 15250257; 15252864; 15256516; 15258198; 15258208; 15258620; 15259389; 15262670; 15264189; 15264223; 15266206; 15266207; 15276243; 15276511; 15277615; 15286151; 15286454; 15286456; 15300423; 15311189; 15312249; 15312696; 15314125; 15319409; 15326233; 15326239; 15326261; 15326295; 15328426; 15331430; 15336915; 15337261; 15337270; 15339912; 15340366; 15345809; 15345810; 15358178; 15359535; 15362374; 15364413; 15364690; 15365129; 15370197; 15370375; 15374124; 15374172; 15375590; 15375600; 15377701; 15377739; 15379569; 15383745; 15448517; 15450205; 15452311; 15455263; 15461196; 15465089; 15465740; 15466371; 15468911; 15469418; 15477512; 15477533; 15477624; 15482730; 15485881; 15487712; 15488782; 15488872; 15489334; 15503099; 15505155; 15514092; 15519745; 15522251; 15523694; 15525904; 15526312; 15530909; 15531082; 15531693; 15534175; 15534246; 15538542; 15540997; 15543563; 15545327; 15548484; 15548496; 15549499; 15549644; 15554031; 15557508; 15559160; 15559755; 15562392; 15563891; 15569012; 15571629; 15571826; 15573849; 15576362; 15579298; 15583000; 15583995; 15584785; 15584908; 15585207; 15585342; 15585780; 15591802; 15592132; 15596614; 15598211; 15600186; 15607989; 15608561; 15611352; 15623696; 15627759; 15627763; 15634227; 15636076; 15636224; 15636592; 15641930; 15642911; 15642920; 15643038; 15644277; 15648787; 15653173; 15653176; 15654758; 15656760; 15657615; 15657798; 15660776; 15663009; 15664112; 15665311; 15668424; 15670698; 15674008; 15678256; 15679697; 15686675; 15689450; 15692115; 15696482; 15696494; 15697227; 15699298; 15699382; 15699383; 15699400; 15699916; 15702779; 15708851; 15713714; 15716154; 15721023; 15725730; 15726267; 15728313; 15730956; 15735320; 15739386; 15746021; 15748778; 15754975; 15754976; 15755832; 15760646; 15764642; 15767511; 15769204; 15769335; 15769795; 15774818; 15781953; 15785096; 15791170; 15793777; 15793794; 15804918; 15805147; 15809232; 15809899; 15817610; 15819712; 15820227; 15824354; 15825968; 15829498; 15830056; 15830139; 15834029; 15838630; 15841787; 15843343; 15852364; 15854776; 15860477; 15861030; 15862889; 15863833; 15867282; 15879922; 15880838; 15882073; 15882786; 15883313; 15895300; 15895461; 15896001; 15903153; 15904995; 15910869; 15919549; 15921030; 15925094; 15931081; 15931608; 15932949; 15935014; 15936307; 15936464; 15936467; 15939044; 15942165; 15942426; 15944651; 15950758; 15952022; 15953853; 15956166; 15956169; 15956634; 15961292; 15964100; 15975088; 15979312; 15983323; 15992403; 15998356; 16005361; 16013355; 16013913; 16015283; 16019571; 16021346; 16023140; 16027737; 16028714; 16030523; 16033781; 16033878; 16038892; 16039291; 16040191; 16043164; 16043796; 16051894; 16055229; 16082716; 16086293; 16092050; 16096813; 16099324; 16099779; 16100021; 16103669; 16103896; 16106048; 16107349; 16110302; 16113584; 16116137; 16116614; 16118069; 16122874; 16123547; 16127101; 16128374; 16131735; 16131797; 16133550; 16136540; 16142021; 16142566; 16143024; 16148883; 16152798; 16153291; 16157450; 16157749; 16161810; 16165272; 16166776; 16169331; 16170092; 16176061; 16176168; 16179831; 16182410; 16183800; 16185081; 16186632; 16188386; 16189709; 16193886; 16195918; 16199552; 16199891; 16201140; 16202217; 16202482; 16204452; 16207619; 16207841; 16210555; 16223550; 16233903; 16242874; 16248984; 16250071; 16251607; 16254254; 16254428; 16257094; 16258842; 16261623; 16266401; 16270124; 16275829; 16275840; 16276010; 16276176; 16278220; 16278853; 16282051; 16282567; 16288198; 16295048; 16298355; 16298992; 16299033; 16306239; 16306248; 16314757; 16317171; 16327942; 16328515; 16332659; 16334787; 16335008; 16337304; 16340087; 16343062; 16344478; 16351773; 16352910; 16358334; 16362800; 16367893; 16368754; 16374834; 16378065; 16380608; 16382017; 16385096; 16387995; 16388493; 16389198; 16389649; 16390369; 16390371; 16391475; 16399213; 16401069; 16401755; 16401842; 16402284; 16406547; 16410051; 16417614; 16418216; 16421115; 16421347; 16423463; 16426594; 16432152; 16433808; 16434658; 16443328; 16443932; 16445917; 16446541; 16449871; 16450255; 16453339; 16459141; 16459715; 16462203; 16465366; 16465461; 16466170; 16473016; 16475114; 16476806; 16480703; 16484411; 16484645; 16485778; 16487435; 16490049; 16497717; 16501668; 16503883; 16511213; 16511556; 16519597; 16520487; 16522905; 16524875; 16528057; 16533971; 16533972; 16537024; 16540406; 16540478; 16542392; 16543533; 16544732; 16545358; 16546302; 16557295; 16567081; 16574921; 16585474; 16595160; 16595618; 16599342; 16603077; 16606866; 16606914; 16608402; 16611016; 16614010; 16621107; 16626758; 16630553; 16631424; 16634464; 16635548; 16639317; 16644874; 16645276; 16650578; 16682670; 16682673; 16682795; 16684399; 16686878; 16697650; 16699281; 16699282; 16701920; 16713503; 16714010; 16714771; 16715842; 16720801; 16725228; 16738250; 16740268; 16740596; 16741934; 16752225; 16758323; 16760224; 16763159; 16763161; 16764677; 16766085; 16769085; 16770077; 16778644; 16796589; 16799145; 16799405; 16807921; 16813599; 16814428; 16815257; 16817024; 16823865; 16829344; 16831961; 16832771; 16839689; 16841077; 16842800; 16847429; 16848156; 16862278; 16866904; 16869227; 16869455; 16882462; 16888319; 16894123; 16896546; 16897605; 16900882; 16904828; 16908746; 16914837; 16916985; 16916989; 16917677; 16926234; 16926537; 16927707; 16928730; 16930470; 16930778; 16932075; 16933203; 16935699; 16936080; 16938285; 16943616; 16944667; 16945218; 16946187; 16951484; 16953165; 16954688; 16956959; 16959267; 16960022; 16968945; 16971231; 16973370; 16980336; 16988505; 16996683; 16996687; 16997460; 16997467; 17006673; 17010251; 17011669; 17012232; 17016617; 17020396; 17022778; 17023092; 17030756; 17038035; 17048007; 17050040; 17056835; 17069783; 17077159; 17077632; 17079229; 17089130; 17092867; 17094271; 17095737; 17100508; 17100509; 17101827; 17105389; 17106421; 17108687; 17111197; 17113231; 17115907; 17116317; 17121308; 17123304; 17124416; 17126308; 17127808; 17129575; 17130180; 17132969; 17133176; 17138935; 17140155; 17154273; 17158432; 17161508; 17171228; 17172560; 17174184; 17174555; 17183148; 17192785; 17198524; 17199722; 17200925; 17201525; 17202849; 17203511; 17204369; 17210134; 17210851; 17210854; 17217095; 17217375; 17218903; 17224309; 17224996; 17228342; 17230455; 17234631; 17234815; 17243563; 17244188; 17250852; 17250929; 17254710; 17264404; 17265535; 17272620; 17273655; 17278624; 17280645; 17283313; 17283328; 17287237; 17289397; 17293007; 17293537; 17294608; 17296843; 17299019; 17304721; 17305370; 17310023; 17310037; 17310043; 17317784; 17317888; 17318300; 17322072; 17325732; 17326667; 17328917; 17336705; 17336988; 17337010; 17339538; 17342071; 17350142; 17353005; 17356546; 17367583; 17367769; 17374951; 17376122; 17376543; 17378730; 17379005; 17384433; 17389798; 17393220; 17401152; 17408064; 17410707; 17418914; 17420099; 17420762; 17426996; 17427190; 17430597; 17431774; 17433475; 17433528; 17434289; 17436307; 17451062; 17454231; 17455988; 17460153; 17460172; 17460173; 17460724; 17462871; 17466415; 17474819; 17481771; 17484618; 17485234; 17488453; 17498878; 17503098; 17503475; 17506774; 17509484; 17509769; 17515539; 17518534; 17519358; 17524782; 17535270; 17537154; 17539949; 17540481; 17540618; 17541051; 17544378; 17545732; 17553421; 17553597; 17559337; 17559752; 17560689; 17562993; 17564514; 17565217; 17567623; 17570245; 17578972; 17579348; 17586559; 17594534; 17596691; 17597169; 17603766; 17606532; 17607431; 17611642; 17613540; 17614163; 17621165; 17622762; 17623814; 17624465; 17627113; 17628213; 17636061; 17640473; 17643539; 17653444; 17658295; 17659264; 17659844; 17660382; 17666042; 17669363; 17672902; 17676504; 17684217; 17689412; 17689519; 17696931; 17698206; 17700364; 17702883; 17702967; 17704619; 17706019; 17706090; 17709709; 17710250; 17711604; 17715945; 17716229; 17720148; 17721242; 17721898; 17727701; 17727891; 17728664; 17763167; 17767697; 17784784; 17822808; 17822846; 17822919; 17826340; 17846270; 17848120; 17848837; 17852827; 17854398; 17855807; 17878422; 17883422; 17888544; 17889142; 17890503; 17891567; 17893696; 17904251; 17911363; 17911980; 17913825; 17914184; 17918142; 17920160; 17921131; 17921435; 17932679; 17932993; 17934638; 17936795; 17938569; 17941342; 17957227; 17966072; 17967500; 17971433; 17974013; 17975299; 17975753; 17979899; 17982164; 17982892; 17985658; 17986098; 17986934; 17987251; 17994314; 17995970; 17996334; 17997273; 17998437; 18003940; 18022660; 18023277; 18023533; 18025782; 18027070; 18030173; 18033754; 18034366; 18036514; 18041613; 18046082; 18047842; 18051367; 18052682; 18055294; 18056683; 18056971; 18057084; 18057558; 18057979; 18058831; 18060780; 18063831; 18069348; 18071037; 18077821; 18078695; 18079687; 18081155; 18083276; 18083630; 18086568; 18087668; 18094576; 18155247; 18156727; 18157657; 18159095; 18159991; 18160145; 18161859; 18163216; 18163421; 18163432; 18164902; 18171282; 18179501; 18179845; 18179924; 18183499; 18185033; 18185940; 18187430; 18188530; 18189240; 18190728; 18191876; 18193043; 18193044; 18195144; 18195264; 18197377; 18198422; 18201068; 18201725; 18205760; 18210157; 18210832; 18216863; 18217885; 18219091; 18219093; 18235080; 18236001; 18236205; 18237822; 18239197; 18241317; 18241895; 18242850; 18242855; 18243212; 18248894; 18250093; 18253865; 18256266; 18256366; 18258338; 18258638; 18258839; 18262228; 18266965; 18272374; 18273624; 18274205; 18274923; 18275964; 18280677; 18280754; 18287165; 18289451; 18289550; 18296645; 18297189; 18298341; 18298348; 18301447; 18303265; 18305286; 18307033; 18307571; 18308428; 18317192; 18317248; 18318693; 18318702; 18320120; 18322386; 18324906; 18325076; 18326082; 18329006; 18332630; 18334538; 18334739; 18334912; 18334913; 18346114; 18346764; 18349428; 18354102; 18359130; 18359298; 18359537; 18360691; 18365330; 18367629; 18370334; 18373478; 18374494; 18376055; 18376061; 18376083; 18378026; 18378080; 18378884; 18381771; 18382765; 18388879; 18394363; 18395888; 18395955; 18396294; 18398670; 18401020; 18401023; 18401171; 18401173; 18407659; 18408364; 18416843; 18423577; 18423940; 18430993; 18430994; 18430999; 18439297; 18439548; 18439552; 18443545; 18443916; 18446027; 18452187; 18454345; 18458218; 18461138; 18464295; 18465245; 18468259; 18469278; 18477980; 18478972; 18484674; 18486114; 18486492; 18492292; 18494374; 18495299; 18498549; 18504448; 18505684; 18507396; 18511728; 18511754; 18511872; 18512131; 18513389; 18515697; 18520426; 18525129; 18525196; 18534867; 18549811; 18555606; 18560129; 18562290; 18572260; 18576210; 18580587; 18580594; 18581272; 18581664; 18583979; 18590026; 18593285; 18593777; 18596051; 18600472; 18603262; 18606479; 18607773; 18609102; 18609337; 18614883; 18615849; 18617739; 18619685; 18619712; 18620351; 18620605; 18631256; 18636124; 18641720; 18641859; 18645733; 18652551; 18653200; 18655030; 18656208; 18660489; 18664147; 18667124; 18668226; 18672349; 18676680; 18678795; 18685254; 18685811; 18690708; 18702945; 18705678; 18706476; 18707245; 18708484; 18715507; 18717723; 18718521; 18721259; 18721571; 18722591; 18723162; 18725658; 18728123; 18728174; 18753423; 18755411; 18757293; 18757771; 18760194; 18760504; 18762952; 18765933; 18774543; 18779276; 18779428; 18784741; 18786162; 18790459; 18802019; 18805361; 18808654; 18810496; 18813964; 18819891; 18823527; 18823563; 18823627; 18827228; 18829593; 18829694; 18838195; 18838196; 18839184; 18841008; 18843182; 18843194; 18843526; 18846579; 18848805; 18850190; 18851860; 18853460; 18926856; 18927546; 18930114; 18930458; 18936542; 18937849; 18938676; 18945448; 18946731; 18948255; 18957849; 18959431; 18971492; 18974580; 18974842; 18976728; 18976833; 18981067; 18982063; 18983893; 18983895; 18990452; 18991685; 18992263; 18997294; 19000312; 19001172; 19004527; 19006190; 19008959; 19010425; 19013250; 19013289; 19013689; 19014618; 19015224; 19017669; 19018779; 19020708; 19020798; 19025529; 19025720; 19034316; 19035714; 19047559; 19054180; 19054188; 19056482; 19056656; 19056867; 19057990; 19058936; 19059330; 19060906; 19060911; 19064751; 19066116; 19066720; 19072566; 19073159; 19086990; 19093949; 19094657; 19103187; 19105203; 19111900; 19116453; 19118814; 19124009; 19124691; 19125160; 19130493; 19131662; 19135213; 19136831; 19140312; 19140315; 19142571; 19145250; 19148283; 19148342; 19148546; 19154537; 19155747; 19155782; 19157170; 19158433; 19158597; 19159618; 19164761; 19165527; 19166449; 19169966; 19170196; 19172988; 19181718; 19184337; 19184578; 19187685; 19194887; 19195718; 19197348; 19199499; 19199875; 19207139; 19209940; 19210035; 19210038; 19217440; 19217759; 19218241; 19218599; 19221972; 19238444; 19241136; 19243844; 19244370; 19244396; 19245412; 19246912; 19250583; 19251191; 19251758; 19252179; 19255409; 19255410; 19259132; 19262954; 19262956; 19263529; 19266700; 19273753; 19274077; 19276544; 19276554; 19278396; 19278567; 19282863; 19285755; 19290744; 19293566; 19295164; 19297138; 19299407; 19300863; 19303604; 19304773; 19307174; 19307538; 19307863; 19308307; 19308965; 19321880; 19322689; 19326444; 19335933; 19336370; 19336475; 19339712; 19341173; 19349228; 19349827; 19357304; 19362884; 19363264; 19363267; 19363270; 19365373; 19367093; 19367581; 19368122; 19368142; 19368828; 19368854; 19368855; 19368858; 19372276; 19375284; 19377787; 19382113; 19384966; 19388128; 19394408; 19394849; 19398704; 19403283; 19405181; 19408164; 19409232; 19409447; 19420105; 19420940; 19421411; 19422789; 19429797; 19433657; 19433661; 19449451; 19450584; 19455140; 19457062; 19457069; 19459027; 19470200; 19473356; 19474452; 19477221; 19478482; 19479237; 19481150; 19484916; 19493541; 19494432; 19494437; 19494491; 19494537; 19499236; 19501493; 19504470; 19506792; 19515369; 19521084; 19524160; 19524323; 19529002; 19531688; 19534808; 19539034; 19539718; 19541455; 19542606; 19542737; 19545491; 19545933; 19551707; 19553347; 19554612; 19557866; 19560323; 19563454; 19564306; 19565203; 19567438; 19570164; 19578553; 19578796; 19583979; 19584447; 19584451; 19587357; 19589783; 19590821; 19591129; 19597098; 19602472; 19605830; 19615060; 19618379; 19619878; 19625176; 19625744; 19628211; 19629426; 19631387; 19631758; 19633944; 19635584; 19636640; 19639019; 19641318; 19642912; 19644067; 19645623; 19647324; 19653879; 19656773; 19660787; 19664276; 19664850; 19667110; 19667307; 19668025; 19668339; 19675403; 19679070; 19684401; 19685167; 19686716; 19689828; 19691831; 19692168; 19693485; 19698138; 19704080; 19713000; 19713976; 19716217; 19717024; 19720974; 19722128; 19725829; 19729601; 19732892; 19733021; 19733630; 19734902; 19734903; 19742390; 19744893; 19747047; 19748159; 19748619; 19750560; 19751943; 19752580; 19758344; 19761888; 19765634; 19766540; 19773416; 19786693; 19800705; 19804477; 19808960; 19812458; 19812463; 19812466; 19813626; 19816504; 19818961; 19819279; 19819468; 19822782; 19823059; 19824992; 19825914; 19828088; 19842071; 19845562; 19848197; 19851068; 19851649; 19852818; 19853876; 19857550; 19859025; 19859026; 19860767; 19879282; 19879666; 19884594; 19884614; 19884647; 19888660; 19888930; 19889709; 19890394; 19891383; 19896333; 19897004; 19899640; 19901170; 19901172; 19901249; 19904605; 19906129; 19907180; 19907191; 19910874; 19910883; 19911187; 19911804; 19913121; 19914339; 19915960; 19917453; 19924507; 19926167; 19928390; 19936222; 19939808; 19940477; 19940480; 19943806; 19946803; 19948975; 19951017; 19952867; 19955384; 19958090; 19960482; 19965518; 19965582; 19995442; 19996253; 19997085; 20002130; 20007524; 20014138; 20019593; 20020283; 20029386; 20029801; 20029940; 20030366; 20031273; 20031276; 20031551; 20031552; 20031582; 20032288; 20032478; 20034483; 20037210; 20044476; 20044903; 20058037; 20059631; 20060049; 20061606; 20061627; 20063946; 20065134; 20065135; 20072115; 20072124; 20073019; 20074462; 20074603; 20077482; 20079752; 20088621; 20090368; 20091341; 20094015; 20100581; 20107178; 20116212; 20129626; 20139413; 20145290; 20152880; 20153809; 20157257; 20160191; 20160192; 20160452; 20161734; 20164549; 20164573; 20167577; 20170526; 20172629; 20175773; 20177792; 20182051; 20182542; 20184726; 20186853; 20191120; 20196787; 20197062; 20198498; 20208369; 20213229; 20216394; 20217437; 20219963; 20221865; 20223480; 20227257; 20229631; 20298684; 20301340; 20301414; 20302621; 20304614; 20306566; 20308031; 20308781; 20331378; 20331911; 20332638; 20335123; 20338079; 20340021; 20346360; 20348244; 20350587; 20351714; 20354905; 20362697; 20373031; 20373342; 20373846; 20374396; 20375505; 20376800; 20377344; 20381076; 20381197; 20381392; 20381870; 20382449; 20385913; 20388089; 20389122; 20394740; 20395015; 20396431; 20401432; 20403997; 20406267; 20406466; 20409610; 20410080; 20413122; 20413671; 20413898; 20414590; 20416077; 20416362; 20417063; 20423919; 20425806; 20427016; 20429872; 20430066; 20430392; 20430468; 20430978; 20431431; 20432703; 20436440; 20436990; 20437058; 20437541; 20442634; 20444273; 20446941; 20450896; 20452482; 20453509; 20455859; 20455863; 20456244; 20459474; 20460622; 20463109; 20467002; 20468060; 20469680; 20471857; 20473139; 20479234; 20479360; 20488256; 20491609; 20493672; 20493925; 20498921; 20499136; 20502990; 20508347; 20514637; 20515477; 20523031; 20529013; 20533025; 20533968; 20534741; 20534961; 20535486; 20536507; 20537614; 20538124; 20538372; 20538373; 20538374; 20538375; 20538553; 20541374; 20541611; 20543710; 20546752; 20546958; 20547867; 20548041; 20552590; 20553853; 20554432; 20555142; 20558149; 20558387; 20560916; 20561715; 20562467; 20565774; 20567859; 20569235; 20570401; 20570406; 20571754; 20573574; 20574532; 20576093; 20577623; 20580132; 20583903; 20592257; 20592574; 20598287; 20599283; 20600372; 20602615; 20606435; 20619505; 20620663; 20620664; 20620666; 20625090; 20625167; 20628086; 20634590; 20634891; 20637261; 20640544; 20643407; 20644276; 20644562; 20658496; 20660919; 20663622; 20667498; 20667857; 20673868; 20674461; 20674675; 20677882; 20678545; 20679343; 20679960; 20682199; 20682673; 20682755; 20686185; 20686565; 20686979; 20687780; 20688498; 20689279; 20691505; 20691792; 20693183; 20693622; 20693633; 20697030; 20697334; 20697532; 20700462; 20700730; 20705142; 20709332; 20711061; 20713315; 20714348; 20715976; 20719944; 20723945; 20724907; 20725527; 20727736; 20729396; 20729559; 20733306; 20734064; 20734437; 20739349; 20739760; 20804847; 20808139; 20810250; 20810324; 20813341; 20813342; 20815153; 20817350; 20817608; 20818931; 20819998; 20820000; 20820167; 20822524; 20825268; 20826689; 20832534; 20833446; 20837363; 20838585; 20845403; 20847397; 20847408; 20847432; 20847553; 20847559; 20849521; 20850903; 20851099; 20855565; 20858958; 20858975; 20861163; 20861397; 20864672; 20868652; 20872969; 20876472; 20877692; 20880000; 20880354; 20880607; 20883677; 20884673; 20885792; 20888920; 20889503; 20919569; 20930274; 20930297; 20930301; 20932310; 20935323; 20940625; 20946940; 20947215; 20951391; 20951774; 20954076; 20961174; 20961200; 20964956; 20966513; 20971101; 20972250; 20975297; 20980669; 21033077; 21039385; 21048770; 21054877; 21059196; 21059989; 21061402; 21063236; 21073671; 21074899; 21079443; 21080234; 21084733; 21098974; 21108621; 21110240; 21114327; 21116912; 21116929; 21123754; 21124005; 21124030; 21132386; 21132529; 21143177; 21159973; 21163235; 21163916; 21163940; 21169230; 21184197; 21190051; 21192234; 21192235; 21208197; 21218563; 21219628; 21222606; 21224004; 21225522; 21228824; 21232817; 21240353; 21243303; 21244352; 21244662; 21245410; 21251163; 21252538; 21252539; 21252542; 21254242; 21254576; 21261723; 21263195; 21263443; 21266206; 21266538; 21276236; 21283692; 21283811; 21284913; 21289314; 21290252; 21296594; 21297273; 21297948; 21310412; 21317045; 21322570; 21324265; 21324458; 21325652; 21325775; 21332925; 21346330; 21346518; 21347323; 21350196; 21360299; 21372127; 21379329; 21380728; 21383266; 21388338; 21396385; 21401257; 21402364; 21407046; 21409287; 21418511; 21420681; 21435264; 21443265; 21443344; 21450082; 21451572; 21453125; 21454574; 21461956; 21464541; 21471207; 21474829; 21474934; 21478199; 21482441; 21488185; 21493755; 21500980; 21517181; 21533863; 21534737; 21541275; 21545304; 21549723; 21550086; 21552550; 21555604; 21555637; 21556001; 21570960; 21575667; 21576687; 21593560; 21595502; 21605063; 21606569; 21613490; 21617520; 21627779; 21651315; 21654062; 21659554; 21670560; 21676498; 21679970; 21685781; 21689001; 21701228; 21703254; 21710128; 21714002; 21714688; 21723395; 21724665; 21728427; 21740922; 21741316; 21743035; 21743131; 21756796; 21760580; 21763789; 21767357; 21768502; 21769591; 21782446; 21788110; 21790705; 21792545; 21798384; 21798539; 21799244; 21799773; 21803164; 21803501; 21819245; 21822540; 21825236; 21829380; 21835633; 21840004; 21845591; 21845926; 21848287; 21849821; 21851856; 21856047; 21857382; 21864519; 21869487; 21873229; 21882290; 21889115; 21892657; 21895520; 21905100; 21908077; 21909109; 21911656; 21934306; 21939561; 21943158; 21945984; 21952537; 21954452; 21958003; 21971450; 21973221; 21984189; 21988832; 21992747; 22005931; 22006422; 22010136; 22012848; 22013795; 22015765; 22016362; 22028770; 22039842; 22054870; 22055839; 22056199; 22056562; 22058162; 22068907; 22069463; 22069485; 22071360; 22074026; 22089642; 22100309; 22101739; 22101883; 22101914; 22102296; 22106308; 22108393; 22110642; 22113353; 22129783; 22130662; 22134129; 22138302; 22159055; 22159114; 22165672; 22173784; 22174202; 22178106; 22178110; 22179327; 22185986; 22189452; 22200909; 22204031; 22206590; 22206848; 22211488; 22221491; 22221592; 22225956; 22226379; 22226798; 22228589; 22232206; 22234866; 22238606; 22244650; 22245009; 22246233; 22251476; 22264578; 22266326; 22269984; 22272622; 22272623; 22285757; 22286219; 22291217; 22311091; 22322856; 22328704; 22329498; 22331829; 22334766; 22343410; 22344634; 22348880; 22349451; 22350157; 22353753; 22357643; 22359096; 22365656; 22381401; 22383234; 22383685; 22392034; 22394699; 22396775; 22398564; 22399527; 22410653; 22414761; 22414959; 22419519; 22440829; 22445724; 22462403; 22465377; 22481068; 22487820; 22490376; 22492035; 22502727; 22520940; 22532692; 22534472; 22535266; 22539578; 22542837; 22544617; 22549621; 22558310; 22562716; 22568769; 22580620; 22596266; 22612575; 22615372; 22621984; 22632920; 22633529; 22635103; 22637583; 22642392; 22675504; 22676395; 22689192; 22698480; 22699906; 22710912; 22712640; 22721421; 22728266; 22730380; 22735491; 22755192; 22760259; 22771913; 22784692; 22785395; 22787761; 22796460; 22815080; 22821396; 22825739; 22826377; 22832961; 22837136; 22844488; 22848551; 22862561; 22863665; 22868934; 22869155; 22874659; 22883220; 22883908; 22889670; 22890094; 22890095; 22898894; 22899317; 22902767; 22904031; 22914590; 22914594; 22916037; 22918225; 22921891; 22927174; 22935789; 22936261; 22949395; 22955176; 22961083; 22967844; 22971752; 22972946; 22976236; 22982410; 22984509; 22986607; 22991192; 23011382; 23022416; 23023254; 23031429; 23036023; 23040522; 23042108; 23042215; 23049877; 23050006; 23051684; 23051975; 23056479; 23060451; 23063453; 23064258; 23067351; 23071163; 23079898; 23088986; 23091810; 23096223; 23098561; 23100402; 23100439; 23102119; 23103838; 23110764; 23110818; 23113606; 23118302; 23123227; 23132858; 23134888; 23134962; 23142051; 23142524; 23146133; 23152815; 23159043; 23159296; 23171142; 23175721; 23183136; 23186985; 23204275; 23213264; 23232444; 23238736; 23242296; 23242623; 23247007; 23251595; 23255503; 23255822; 23270420; 23272070; 23273617; 23275593; 23286790; 23288845; 23289212; 23290018; 23291160; 23292450; 23293020; 23296339; 23302659; 23312054; 23317568; 23320904; 23321337; 23324992; 23326517; 23364031; 23371373; 23372804; 23380990; 23382465; 23384034; 23384292; 23385359; 23396426; 23407349; 23407718; 23408335; 23411028; 23413428; 23415434; 23419831; 23424640; 23429815; 23430611; 23430745; 23455636; 23466070; 23492875; 23503772; 23522842; 23525328; 23537987; 23546960; 23553344; 23562540; 23565137; 23571587; 23573206; 23576895; 23581910; 23583468; 23584199; 23587637; 23587689; 23588940; 23590983; 23593485; 23603214; 23612909; 23613766; 23620513; 23624169; 23631810; 23631828; 23642733; 23652625; 23660682; 23663404; 23669301; 23684315; 23687437; 23701536; 23723060; 23726366; 23729930; 23731072; 23737466; 23743349; 23769398; 23771217; 23773371; 23779114; 23786792; 23808899; 23815818; 23826174; 23844046; 23844141; 23855979; 23865355; 23876113; 23883936; 23888546; 23902934; 23902937; 23919842; 23965289; 24009459; 24023260; 24023310; 24023758; 24145446; 24145819; 24163986; 24239320; 24276092; 24291031; 24308640; 24340925; 24448836; 24464001
apolipoprotein E
Ensembl:ENSG00000130203
HGNC:613
HPRD:00135
MIM:107741
Vega:OTTHUMG00000128901
Other designations: apo-E|apolipoprotein E3
APOE
Bin Zhao, Yue Liu, Oliver He
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
WEB: http://www.ncbi.nlm.nih.gov/gene
FAS
Fas cell surface death receptor
355
RP11-399O19.7
10q24.1
9606
10
Official from a nomenclature committee
GO_0002377 (EC: IEA); GO_0003014 (EC: IEA); GO_0004871 (EC: TAS, PMID: 10875918); GO_0004872 (EC: NAS, PMID: 7533181); GO_0004888 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10918185); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA); GO_0005829 (EC: NAS, PMID: 7533181); GO_0005886 (EC: IDA); GO_0005886 (EC: IMP); GO_0005886 (EC: TAS); GO_0006461 (EC: TAS, PMID: 10875918); GO_0006915 (EC: IDA, PMID: 9681877); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0006924 (EC: IEA); GO_0006925 (EC: IEA); GO_0006927 (EC: IEA); GO_0007165 (EC: TAS, PMID: 9360929); GO_0008625 (EC: IEA); GO_0009636 (EC: IEA); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA); GO_0016021 (EC: IEA); GO_0019724 (EC: IEA); GO_0019900 (EC: IPI, PMID: 7538908); GO_0031264 (EC: IDA, PMID: 11101870); GO_0031265 (EC: IDA); GO_0032464 (EC: IEA); GO_0042802 (EC: IPI); GO_0042981 (EC: NAS, PMID: 7533181); GO_0043065 (EC: IDA); GO_0043065 (EC: IMP); GO_0043066 (EC: IEA); GO_0045060 (EC: IEA); GO_0045121 (EC: IDA); GO_0045619 (EC: IEA); GO_0045637 (EC: IEA); GO_0048536 (EC: IEA); GO_0050869 (EC: IEA); GO_0051260 (EC: IEA); GO_0051384 (EC: IEA); GO_0070062 (EC: IDA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071285 (EC: IEA); GO_0071455 (EC: IMP); GO_0097049 (EC: IEA); GO_0097190 (EC: TAS); GO_0097191 (EC: IMP); GO_0097192 (EC: IEA); GO_0097527 (EC: IMP, PMID: 16507998); GO_2001239 (EC: TAS); GO_2001241 (EC: IEA)
PMID: 1375228; 1385299; 1385309; 1713127; 2469768; 2787530; 7510905; 7514572; 7529798; 7530336; 7533181; 7536190; 7536343; 7538907; 7538908; 7539892; 7540117; 7542559; 7543095; 7575433; 7859281; 8521815; 8524870; 8598453; 8626376; 8648105; 8681376; 8780394; 8864141; 8906799; 8929361; 8940097; 8967952; 8976184; 9002959; 9028321; 9028957; 9039262; 9045686; 9079683; 9082980; 9126929; 9159204; 9199966; 9208847; 9215629; 9223324; 9226175; 9228058; 9247148; 9257699; 9263011; 9267021; 9268734; 9322534; 9325248; 9360929; 9427646; 9475352; 9560245; 9681877; 9721089; 9727492; 9740801; 9751072; 9787134; 9821419; 9835052; 9847311; 9857224; 9920849; 9927496; 9971775; 10068040; 10072505; 10090885; 10200300; 10235259; 10340403; 10462485; 10505674; 10506221; 10535980; 10542291; 10620127; 10625668; 10630977; 10671224; 10706119; 10709732; 10713117; 10799864; 10871852; 10875918; 10918185; 10978533; 11003656; 11034606; 11035039; 11036836; 11048727; 11048730; 11101867; 11101870; 11112409; 11129341; 11177389; 11193028; 11208609; 11298454; 11323689; 11418480; 11436125; 11483955; 11495919; 11550967; 11606059; 11692157; 11733515; 11771526; 11773067; 11779855; 11782802; 11786482; 11786908; 11788891; 11790791; 11809905; 11824955; 11830507; 11836578; 11857317; 11861273; 11864613; 11867183; 11877055; 11891278; 11895550; 11909874; 11920253; 11941452; 11949822; 11961305; 11965496; 11975981; 11986289; 11994542; 12021072; 12032668; 12034188; 12037669; 12040174; 12049185; 12060388; 12060768; 12064832; 12067476; 12096347; 12096925; 12098516; 12107169; 12131184; 12137598; 12139945; 12140383; 12150947; 12163388; 12169207; 12177303; 12185583; 12188927; 12196516; 12198154; 12207331; 12207908; 12220552; 12221075; 12234263; 12244143; 12270344; 12324452; 12372427; 12388693; 12393468; 12393649; 12393889; 12397013; 12414525; 12415011; 12419941; 12452031; 12455036; 12466128; 12477932; 12482410; 12482505; 12485855; 12497631; 12507389; 12513829; 12515395; 12515623; 12516573; 12557947; 12581154; 12583439; 12586732; 12587820; 12604424; 12623840; 12629150; 12646947; 12679613; 12698366; 12699879; 12702723; 12706861; 12710855; 12717632; 12724420; 12742662; 12742739; 12753742; 12757469; 12770553; 12783210; 12788915; 12794152; 12803240; 12824926; 12855571; 12855687; 12867600; 12874203; 12880639; 12883671; 12887920; 12907599; 12923319; 12952224; 12963547; 14506242; 14512182; 14514471; 14530312; 14533029; 14534720; 14557654; 14573612; 14585083; 14594800; 14625033; 14625298; 14625471; 14637155; 14638442; 14644092; 14644197; 14644318; 14647422; 14668794; 14672901; 14676203; 14694156; 14698859; 14714559; 14719092; 14719118; 14724564; 14736971; 14739003; 14739535; 14739941; 14745445; 14759258; 14967838; 14977837; 14981943; 14991945; 15016553; 15019807; 15039424; 15042330; 15054468; 15055260; 15078899; 15138553; 15159312; 15159409; 15160902; 15161716; 15183989; 15203866; 15207703; 15214041; 15215233; 15218339; 15220220; 15238425; 15240787; 15251990; 15277733; 15280387; 15287856; 15289903; 15297424; 15301860; 15345718; 15365741; 15383280; 15390286; 15459302; 15465831; 15467462; 15480430; 15489334; 15492869; 15497017; 15500551; 15502938; 15514680; 15542843; 15556626; 15556941; 15557123; 15563545; 15592292; 15617242; 15632129; 15637757; 15641141; 15645122; 15659383; 15665818; 15670977; 15672026; 15680394; 15688389; 15695771; 15704653; 15723707; 15726829; 15748958; 15786554; 15795317; 15803113; 15806311; 15808689; 15816832; 15818415; 15829968; 15833141; 15838728; 15843521; 15855233; 15858021; 15860671; 15894356; 15907374; 15911745; 15917238; 15929764; 15936090; 15937082; 15938782; 15944736; 15962371; 15963548; 15967797; 15968727; 15972662; 15975999; 15996722; 16000573; 16018969; 16081586; 16087126; 16091761; 16124644; 16129703; 16143308; 16148554; 16157125; 16158329; 16163374; 16169070; 16215672; 16215685; 16255757; 16273638; 16304056; 16306044; 16313826; 16343245; 16344560; 16358967; 16364925; 16368755; 16385451; 16393952; 16403915; 16436054; 16438619; 16441482; 16463650; 16469115; 16472594; 16473667; 16474169; 16507928; 16507998; 16515587; 16524887; 16538171; 16538172; 16643620; 16691186; 16723718; 16736614; 16741989; 16750039; 16765090; 16788566; 16808908; 16820946; 16822901; 16895904; 16899302; 16914910; 16917513; 16921240; 16936193; 16937440; 16948902; 16972019; 16987075; 17000697; 17006606; 17009393; 17014078; 17014925; 17053166; 17056024; 17062728; 17130290; 17135269; 17159907; 17159908; 17161551; 17174268; 17183065; 17194564; 17195092; 17198275; 17203787; 17219051; 17336828; 17376892; 17406980; 17465232; 17485109; 17487740; 17493146; 17504511; 17516614; 17544837; 17545588; 17559541; 17561354; 17564320; 17589525; 17597021; 17598974; 17603079; 17622942; 17657164; 17657791; 17667965; 17684774; 17692455; 17704746; 17704785; 17708363; 17724145; 17762757; 17853317; 17878356; 17891455; 17909299; 17912028; 17912957; 17916181; 17932249; 17938571; 17941899; 17962219; 17962369; 17970696; 17978477; 17982483; 17993614; 17997887; 18000680; 18003704; 18029348; 18045865; 18056484; 18057579; 18068525; 18078642; 18078929; 18088463; 18090928; 18162459; 18174230; 18208868; 18217400; 18220834; 18227168; 18234961; 18243739; 18268284; 18292515; 18302883; 18316328; 18324486; 18328427; 18337305; 18342935; 18361934; 18383830; 18411295; 18422813; 18427836; 18439588; 18441236; 18445624; 18463097; 18473402; 18483392; 18488389; 18494554; 18505906; 18508922; 18508927; 18512812; 18548110; 18552209; 18561948; 18582468; 18588573; 18609513; 18614439; 18635548; 18666137; 18676032; 18679533; 18685642; 18718055; 18727868; 18753860; 18754288; 18757527; 18787411; 18796602; 18800686; 18804468; 18813857; 18818748; 18844072; 18844210; 18851835; 18854777; 18923451; 18948840; 18949391; 18949744; 18972838; 19004284; 19009351; 19010354; 19012493; 19015953; 19019335; 19019483; 19020991; 19037097; 19043361; 19047119; 19067240; 19073786; 19076218; 19077906; 19103758; 19112091; 19118384; 19125371; 19141320; 19141860; 19146781; 19155494; 19161534; 19168581; 19170196; 19173804; 19181929; 19219602; 19225810; 19240174; 19241965; 19262492; 19263494; 19266094; 19270351; 19272297; 19293475; 19298528; 19305072; 19332441; 19336370; 19391241; 19404646; 19458913; 19480241; 19487421; 19509307; 19521670; 19527514; 19538867; 19538884; 19542541; 19561642; 19565204; 19572057; 19573080; 19593445; 19615968; 19625176; 19628789; 19634684; 19653342; 19669200; 19680267; 19692168; 19692467; 19698994; 19716115; 19718569; 19723039; 19726736; 19737931; 19751723; 19758996; 19759548; 19766542; 19773279; 19788921; 19789190; 19798106; 19810143; 19811416; 19812265; 19817952; 19826071; 19890662; 19895798; 19911702; 19913121; 19926197; 19927299; 19937732; 19940360; 19941645; 19950259; 19954064; 19966861; 20012528; 20052288; 20064083; 20074157; 20085233; 20101431; 20106900; 20137575; 20140262; 20164160; 20181888; 20187936; 20193111; 20204402; 20205514; 20219325; 20222173; 20237496; 20301287; 20352431; 20353032; 20359312; 20360470; 20378664; 20380574; 20385987; 20393185; 20394629; 20396760; 20396799; 20408337; 20416077; 20438363; 20438666; 20453000; 20470393; 20501759; 20505730; 20534173; 20547950; 20553075; 20558744; 20568250; 20572163; 20618494; 20620960; 20628086; 20629322; 20638642; 20658220; 20666744; 20673483; 20682001; 20694011; 20726226; 20737708; 20800603; 20802294; 20813889; 20819778; 20822933; 20842669; 20876301; 20934723; 20935634; 20936988; 20947025; 20951677; 20953611; 20959405; 20960177; 20981796; 21036138; 21041692; 21048031; 21049406; 21076068; 21081533; 21087335; 21103345; 21107705; 21120501; 21131755; 21145805; 21167737; 21173302; 21196076; 21233219; 21250890; 21257927; 21271302; 21286777; 21317766; 21321117; 21324892; 21354149; 21359408; 21382479; 21390503; 21430781; 21454681; 21466843; 21468569; 21485506; 21490157; 21516345; 21518761; 21526201; 21526501; 21528407; 21530489; 21549565; 21550977; 21557211; 21557277; 21613217; 21619451; 21625619; 21651830; 21691772; 21706480; 21717192; 21729539; 21741956; 21752354; 21757675; 21762074; 21792914; 21793106; 21803845; 21806408; 21808135; 21852034; 21864388; 21864851; 21869830; 21879377; 21885602; 21906983; 21910009; 21912376; 21917312; 21940365; 21961589; 21963094; 21971214; 21988832; 22027769; 22036455; 22042271; 22065776; 22076446; 22084312; 22095627; 22147197; 22173501; 22182632; 22183068; 22186140; 22194871; 22197557; 22199270; 22207003; 22211869; 22237435; 22252758; 22285488; 22299671; 22331638; 22344564; 22352690; 22357491; 22364882; 22386066; 22398398; 22422199; 22425739; 22431000; 22438247; 22492046; 22499988; 22508480; 22609371; 22622132; 22631677; 22645131; 22649200; 22669972; 22670178; 22677152; 22683265; 22698280; 22702044; 22706245; 22726303; 22752343; 22771321; 22805310; 22806078; 22815944; 22821704; 22842170; 22864571; 22891283; 22898262; 22934709; 22946667; 22983578; 22992806; 23033661; 23045958; 23053964; 23065220; 23114924; 23152563; 23153021; 23166734; 23234803; 23235765; 23240581; 23251661; 23269121; 23280017; 23285481; 23322903; 23326385; 23326448; 23326557; 23327061; 23330016; 23333919; 23338968; 23364796; 23372841; 23392773; 23420824; 23430061; 23434371; 23492187; 23499736; 23524443; 23580232; 23582102; 23582741; 23590971; 23618817; 23619472; 23636796; 23662689; 23667901; 23681795; 23697029; 23762329; 23770605; 23792529; 23846229; 23865866; 23880344; 23894399; 23900676; 23923075; 23932896; 23979975; 24014103; 24043286; 24091673; 24178789; 24331540
Fas cell surface death receptor
Ensembl:ENSG00000026103
HGNC:11920
HPRD:00609
MIM:134637
Vega:OTTHUMG00000018701
Other designations: APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6
FAS
Bin Zhao, Yue Liu, Oliver He
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
WEB: http://www.ncbi.nlm.nih.gov/gene
FASLG
Fas ligand (TNF superfamily, member 6)
356
1q23
9606
1
Official from a nomenclature committee
GO_0000122 (EC: IDA, PMID: 17557115); GO_0005102 (EC: TAS, PMID: 7826947); GO_0005125 (EC: IEA); GO_0005164 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12198154); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 18835034); GO_0005634 (EC: IDA, PMID: 17557115); GO_0005887 (EC: TAS, PMID: 7826947); GO_0005901 (EC: IEA); GO_0006351 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IGI, PMID: 19364818); GO_0006919 (EC: IMP, PMID: 18293083); GO_0006919 (EC: TAS); GO_0006925 (EC: IEA); GO_0006955 (EC: IEA); GO_0007165 (EC: TAS, PMID: 7826947); GO_0007267 (EC: TAS, PMID: 7826947); GO_0008284 (EC: IEA); GO_0008625 (EC: IDA, PMID: 18835034); GO_0009897 (EC: IEA); GO_0016525 (EC: IDA, PMID: 18835034); GO_0030644 (EC: IEA); GO_0032496 (EC: IEA); GO_0043065 (EC: IDA, PMID: 14749367); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043202 (EC: IEA); GO_0043525 (EC: IEA); GO_0045742 (EC: IEA); GO_0046666 (EC: IEA); GO_0048388 (EC: IEA); GO_0048471 (EC: IEA); GO_0060205 (EC: IEA); GO_0070062 (EC: IDA, PMID: 17076679); GO_0070231 (EC: IDA, PMID: 17076679); GO_0070266 (EC: IDA, PMID: 11101870); GO_0070848 (EC: IEA); GO_0097190 (EC: IDA, PMID: 11101870); GO_0097190 (EC: TAS); GO_0097191 (EC: IDA); GO_0097527 (EC: IDA, PMID: 11101870); GO_2000353 (EC: IDA, PMID: 18835034); GO_2001239 (EC: TAS)
PMID: 7505205; 7528780; 7530336; 7536190; 7539892; 7566174; 7589480; 7826947; 7980502; 8521815; 8681376; 8787672; 8906799; 8910274; 9002959; 9022072; 9126929; 9215629; 9226175; 9228058; 9247148; 9261095; 9405425; 9427603; 9475352; 9672636; 9721089; 9801169; 9872321; 9920849; 9971775; 10072505; 10224289; 10318773; 10630977; 10671224; 10799864; 11013215; 11036836; 11048727; 11101870; 11208609; 11276204; 11438180; 11500835; 11559749; 11606059; 11716959; 11739488; 11741599; 11751256; 11786482; 11788891; 11801650; 11809905; 11830480; 11845233; 11856352; 11882326; 11895550; 11908702; 11909874; 11925103; 11961305; 11965496; 11994433; 11994542; 12009596; 12021072; 12021310; 12023017; 12100038; 12113885; 12137598; 12161534; 12198154; 12208869; 12220636; 12372468; 12393889; 12414525; 12414956; 12421989; 12454289; 12464266; 12477932; 12482410; 12482505; 12490654; 12507389; 12513781; 12515623; 12557947; 12559631; 12583439; 12594300; 12618758; 12629150; 12637505; 12651606; 12698366; 12700199; 12707034; 12710855; 12717632; 12742662; 12742739; 12753742; 12761501; 12783210; 12787425; 12794109; 12803240; 12807917; 12849704; 12854132; 12867600; 12884192; 12887920; 12918731; 12923319; 12928375; 12930319; 14514471; 14534535; 14560009; 14602201; 14625471; 14634098; 14642527; 14644197; 14668794; 14669310; 14698859; 14705811; 14739003; 14739407; 14739535; 14749367; 14962292; 14967838; 14977837; 14988839; 14996347; 15019279; 15042330; 15073283; 15078178; 15093732; 15138553; 15173177; 15178561; 15183989; 15195700; 15218339; 15240787; 15272306; 15277733; 15287856; 15302589; 15314293; 15337758; 15339846; 15358139; 15457562; 15480896; 15489334; 15492869; 15542843; 15557763; 15579659; 15653751; 15659383; 15674374; 15686714; 15694838; 15791651; 15795317; 15803113; 15806311; 15814666; 15816832; 15833141; 15843521; 15849828; 15858021; 15870081; 15870181; 15907374; 15928037; 15936090; 15937082; 15938782; 15962391; 15968727; 15975999; 15979995; 15991293; 15996722; 16000573; 16081306; 16087126; 16124644; 16133992; 16155003; 16157125; 16157266; 16158329; 16163374; 16181301; 16186185; 16204241; 16212902; 16273638; 16282344; 16298578; 16306044; 16313826; 16318909; 16332967; 16332972; 16364925; 16441482; 16474169; 16487513; 16498403; 16512757; 16514159; 16538171; 16538172; 16595635; 16595663; 16601838; 16627752; 16691186; 16710414; 16736614; 16767155; 16770006; 16808908; 16858424; 16868256; 16902496; 16972019; 16987075; 16990614; 17000697; 17008914; 17014925; 17053166; 17056762; 17071607; 17076679; 17101499; 17118988; 17123522; 17123604; 17136494; 17164290; 17173971; 17183065; 17198275; 17290285; 17381722; 17465232; 17491259; 17545588; 17557115; 17559541; 17564320; 17598974; 17605793; 17654480; 17667919; 17688234; 17703232; 17704118; 17704746; 17727731; 17762757; 17823283; 17853317; 17912957; 17916181; 17938571; 17941899; 17943461; 17961631; 17962219; 17966039; 17969524; 17997887; 18000680; 18045865; 18050226; 18057579; 18068525; 18069935; 18076022; 18078642; 18162459; 18174230; 18217400; 18220834; 18292515; 18293083; 18302883; 18314443; 18316328; 18324486; 18359029; 18361934; 18374107; 18383830; 18392917; 18422813; 18427836; 18473402; 18483392; 18501631; 18505906; 18509086; 18541195; 18548110; 18561948; 18567840; 18577653; 18666137; 18676680; 18727868; 18757527; 18789888; 18800686; 18813857; 18818748; 18835034; 18844072; 18854777; 19009351; 19010354; 19015953; 19019335; 19041431; 19052714; 19079288; 19124506; 19141860; 19146781; 19155494; 19170196; 19176318; 19181929; 19183163; 19219602; 19240174; 19244619; 19266094; 19305072; 19332441; 19337311; 19364818; 19390575; 19403301; 19434529; 19458913; 19505222; 19527514; 19531476; 19535642; 19538867; 19542541; 19565204; 19572057; 19573080; 19614955; 19625176; 19628789; 19641134; 19692168; 19773279; 19779494; 19789190; 19807924; 19810143; 19812265; 19826071; 19854829; 19890662; 19926197; 19937732; 19941645; 19960225; 20012528; 20013612; 20074157; 20101459; 20106900; 20150914; 20165911; 20190752; 20193111; 20204402; 20219325; 20222173; 20237496; 20301287; 20353032; 20359312; 20371612; 20378615; 20379197; 20379614; 20385987; 20393600; 20394629; 20406899; 20408337; 20438363; 20501759; 20533543; 20568250; 20572163; 20602615; 20618494; 20624652; 20650551; 20673483; 20675370; 20726934; 20842669; 20959405; 21087335; 21102463; 21107701; 21122378; 21152963; 21159039; 21227011; 21270445; 21271302; 21285513; 21286777; 21354149; 21368861; 21466843; 21516345; 21528407; 21605112; 21691772; 21725926; 21729539; 21746966; 21803845; 21806408; 21807637; 21808135; 21864388; 21864851; 21879377; 21909273; 21910009; 21940365; 21955608; 22027769; 22161157; 22172872; 22182632; 22199323; 22207003; 22211869; 22330070; 22331638; 22341864; 22344564; 22449797; 22461695; 22499988; 22535954; 22558309; 22609371; 22631677; 22645131; 22702044; 22706245; 22726303; 22732091; 22763913; 22821704; 22842170; 22860894; 22927007; 22946667; 23045958; 23065018; 23076876; 23128233; 23153021; 23177026; 23184030; 23192951; 23234803; 23269121; 23280017; 23285481; 23330016; 23392773; 23405244; 23420824; 23504349; 23534738; 23582102; 23618817; 23681795; 23682624; 23697029; 23923075; 24072745; 24178789; 24184557; 24265545; 24291222
Fas ligand (TNF superfamily, member 6)
Ensembl:ENSG00000117560
HGNC:11936
HPRD:00610
MIM:134638
Vega:OTTHUMG00000034841
Other designations: CD95 ligand|apoptosis (APO-1) antigen ligand 1|apoptosis antigen ligand|fas antigen ligand|tumor necrosis factor (ligand) superfamily, member 6|tumor necrosis factor ligand superfamily member 6
FASLG
Bin Zhao, Yue Liu, Oliver He
AC
ACDase
ASAH
PHP
PHP32
SMAPME
WEB: http://www.ncbi.nlm.nih.gov/gene
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
427
HSD33
8p22
9606
8
Official from a nomenclature committee
GO_0003824 (EC: TAS, PMID: 8955159); GO_0006665 (EC: TAS); GO_0006672 (EC: TAS, PMID: 8955159); GO_0006687 (EC: TAS); GO_0008219 (EC: IEA); GO_0010033 (EC: IEA); GO_0017040 (EC: TAS); GO_0030324 (EC: IEA); GO_0043202 (EC: TAS); GO_0044281 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
PMID: 7744740; 8125298; 8889549; 8955159; 9838138; 10610716; 10959093; 10974027; 11241842; 11451951; 12477932; 12638942; 12754519; 12764132; 12815059; 14702039; 15088070; 15210766; 15489334; 16169070; 16263699; 16335952; 16344560; 16500425; 16806233; 17713573; 17881906; 18245333; 18477771; 19056867; 19298866; 19905902; 19913121; 20360068; 20379614; 20520628; 20628086; 20871013; 21139048; 21335555; 21375364; 21493710; 21504271; 21552555; 21700700; 21846728; 21890473; 21893389; 21988832; 22079093; 22261821; 22268729; 22322590; 22515519; 22703880; 22927646; 23423838; 23518908; 23602568; 23707712; 23777806; 24091326
N-acylsphingosine amidohydrolase (acid ceramidase) 1
Ensembl:ENSG00000104763
HGNC:735
HPRD:01969
MIM:613468
Vega:OTTHUMG00000096997
Other designations: acid CDase|acid ceramidase|acylsphingosine deacylase|putative 32 kDa heart protein
ASAH1
Bin Zhao, Yue Liu, Oliver He
ACY2
ASP
WEB: http://www.ncbi.nlm.nih.gov/gene
ASPA
aspartoacylase
443
17p13.3
20140408
9606
17
protein-coding
Official from a nomenclature committee
GO_0004046 (EC: TAS, PMID: 8252036); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0006533 (EC: TAS, PMID: 8252036); GO_0016788 (EC: IEA); GO_0019807 (EC: IEA); GO_0022010 (EC: IEA); GO_0046872 (EC: IEA); GO_0048714 (EC: IEA)
PMID: 27051; 3116332; 7599639; 7668285; 8023850; 8088831; 8252036; 8659549; 9407392; 10564886; 10837925; 10909858; 12205125; 12477932; 12638939; 12706335; 14699612; 15489334; 16189514; 16437572; 16669630; 16935940; 17027983; 17194761; 17391648; 18029348; 18264947; 18293939; 20201926; 20301412; 22019069; 22219087; 22468686; 22750302; 22878930; 23049088
aspartoacylase
HGNC:756
HPRD:02033
MIM:608034
Other designations: ACY-2|aminoacylase 2|aminoacylase-2
ASPA
Bin Zhao, Yue Liu, Oliver He
EWS-ATF1
FUS/ATF-1
TREB36
WEB: http://www.ncbi.nlm.nih.gov/gene
ATF1
activating transcription factor 1
466
12q13
9606
12
GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003700 (EC: TAS, PMID:2196176); GO_0003705 (EC: IEA); GO_0005515 (EC: IPI, PMID:10722738); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0010976 (EC: IEA); GO_0014070 (EC: IEA); GO_0032025 (EC: IEA); GO_0032403 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043565 (EC: IEA); GO_0043623 (EC: IEA); GO_0045087 (EC: TAS); GO_0045740 (EC: IEA); GO_0045944 (EC: IEA); GO_0046982 (EC: IEA); GO_0048011 (EC: TAS); GO_0051403 (EC: TAS)
PMID:1655749; 2196176; 2516827; 7730336; 8384217; 8401579; 8570175; 8621702; 8663317; 8798441; 8889548; 9016641; 9671480; 9685505; 9824209; 10567391; 10585419; 10722738; 10945975; 11014230; 11018520; 11877423; 11909979; 11992546; 12195699; 12391222; 12444143; 12477932; 12527906; 12631284; 12734209; 12748173; 12760902; 12805554; 14767471; 15041276; 15276183; 15489334; 15806162; 15884099; 16227528; 16327442; 16344560; 16716376; 17565989; 18794154; 18950845; 19561568; 19714462; 19913121; 19950226; 20398657; 20413592; 20453000; 20536573; 20628086; 20945072; 20972440; 21484932; 21658281; 21890473; 21963094; 22052915; 22505724; 22510762; 22631637; 22939629; 23000965; 24051143
activating transcription factor 1
Ensembl:ENSG00000123268
HGNC:783
HPRD:00440
MIM:123803
Vega:OTTHUMG00000169482
Other designations: cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1
ATF1
Bin Zhao, Yue Liu, Oliver He
WEB: http://www.ncbi.nlm.nih.gov/gene
ATF3
activating transcription factor 3
467
RP11-338C15.1
1q32.3
9606
1
GO_0003700 (EC: IEA); GO_0003714 (EC: TAS, PMID:7515060); GO_0005515 (EC: IPI, PMID:16291753); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA); GO_0006094 (EC: IEA); GO_0006351 (EC: IEA); GO_0006987 (EC: TAS); GO_0008284 (EC: IEA); GO_0030968 (EC: TAS); GO_0035914 (EC: IEA); GO_0042802 (EC: IPI, PMID:18255255); GO_0043565 (EC: IEA); GO_0044267 (EC: TAS); GO_0045892 (EC: IEA)
PMID:1827203; 2516827; 7515060; 7692236; 8152431; 8576171; 8622660; 8649793; 11375399; 11726207; 11792711; 11810028; 12034827; 12161427; 12372430; 12386811; 12392999; 12477932; 12718878; 12805554; 12833146; 12881527; 14667575; 14673171; 14702039; 14759258; 15280448; 15385533; 15489334; 15670751; 15933712; 16079301; 16109718; 16169070; 16263788; 16286461; 16291753; 16306208; 16344560; 16484797; 16613840; 16912181; 16989641; 17014422; 17042743; 17102133; 17178897; 17295236; 17437852; 17599613; 17952119; 18001166; 18029348; 18192274; 18235102; 18255255; 18426833; 18692824; 18755691; 18802113; 18922905; 19050264; 19060337; 19136462; 19164757; 19219066; 19582787; 19647793; 19913121; 19932681; 20002170; 20110283; 20167600; 20180416; 20211142; 20215396; 20304822; 20351107; 20360311; 20398657; 20413626; 20423458; 20485437; 20581861; 20592017; 20628086; 20696134; 20930144; 21061913; 21129190; 21139048; 21191795; 21294679; 21300803; 21315420; 21324310; 21414204; 21421043; 21451046; 21454613; 21467165; 21495874; 21514952; 21554132; 21593605; 21629765; 21645504; 21668942; 21693764; 21801305; 21821004; 21844328; 21900211; 21906983; 21927023; 21986529; 22046379; 22179317; 22347845; 22475484; 22485215; 22665497; 22753726; 22764884; 22768301; 22851689; 22939624; 22978410; 22989952; 22991139; 23002211; 23088992; 23187734; 23269699; 23455924; 23536558; 23560949; 23661758; 23733932; 23868936; 23921126; 24098051
activating transcription factor 3
Other designations: cAMP-dependent transcription factor ATF-3|cyclic AMP-dependent transcription factor ATF-3
ATF3
Bin Zhao, Yue Liu, Oliver He
CREB-2
CREB2
TAXREB67
TXREB
WEB: http://www.ncbi.nlm.nih.gov/gene
ATF4
activating transcription factor 4
468
22q13.1
9606
22
GO_0003677 (EC: IDA, PMID:15788408); GO_0003677 (EC: ISS); GO_0003700 (EC: ISS); GO_0003700 (EC: TAS, PMID:12689582); GO_0005515 (EC: IPI, PMID:11238952); GO_0005634 (EC: IDA, PMID:16682973); GO_0005634 (EC: ISS); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005737 (EC: ISS); GO_0005815 (EC: IEA); GO_0006094 (EC: ISS); GO_0006355 (EC: ISS); GO_0006366 (EC: ISS); GO_0006520 (EC: TAS, PMID:12689582); GO_0006987 (EC: TAS); GO_0007214 (EC: IEA); GO_0008022 (EC: IEA); GO_0030968 (EC: TAS); GO_0032590 (EC: IEA); GO_0034976 (EC: IDA, PMID:19061639); GO_0043267 (EC: IEA); GO_0043525 (EC: ISS); GO_0043565 (EC: IEA); GO_0044267 (EC: TAS); GO_0045893 (EC: IDA, PMID:15775988); GO_0045893 (EC: IMP, PMID:11960987); GO_0045893 (EC: ISS); GO_0045893 (EC: NAS, PMID:9190894); GO_0045944 (EC: IMP, PMID:15788408); GO_0045944 (EC: ISS); GO_0070059 (EC: ISS)
PMID:1371974; 1534408; 1827203; 1847461; 2516827; 8939898; 9190894; 9295363; 9488481; 10419887; 10591208; 11018027; 11025215; 11087824; 11238952; 11274184; 11564156; 11960987; 12477932; 12689582; 12743605; 12805554; 12812986; 12860379; 14561767; 14623284; 14630807; 14630918; 14695168; 14747470; 15277680; 15314157; 15385533; 15461802; 15475356; 15489334; 15677469; 15775988; 15788408; 16169070; 16189514; 16219772; 16343488; 16682973; 16687408; 16751776; 17042743; 17346882; 17347301; 17369260; 17684156; 17707795; 17726049; 17822787; 17938202; 17996332; 18052253; 18163433; 18171674; 18189280; 18195013; 18255255; 18276110; 18408768; 18451308; 18635891; 18697751; 18940792; 19017641; 19053519; 19061639; 19073601; 19114033; 19164757; 19193809; 19251251; 19417138; 19447967; 19453261; 19509279; 19855386; 19922526; 19946894; 20022965; 20185790; 20211142; 20398657; 20473272; 20514020; 20551969; 20564243; 20592469; 20724472; 20732869; 20873783; 20936779; 21044953; 21087962; 21113145; 21203563; 21244365; 21683813; 21693764; 21706477; 21801305; 21832049; 21866569; 21906983; 21951999; 21963094; 21966512; 21988832; 22007000; 22016052; 22017875; 22050711; 22052162; 22082360; 22233381; 22246806; 22338651; 22363646; 22422769; 22435535; 22485215; 22609407; 22691366; 22813743; 22848420; 22915762; 22955275; 23001845; 23078367; 23090478; 23128233; 23153536; 23205607; 23241898; 23242184; 23339444; 23392669; 23471465; 23661758; 23665047; 23792164; 23908598; 23975372; 24021586
activating transcription factor 4
Ensembl:ENSG00000128272
HGNC:786
HPRD:06817
MIM:604064
Vega:OTTHUMG00000151099
Other designations: DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
ATF4
Bin Zhao, Yue Liu, Oliver He
FCTCS
FRP1
MEC1
SCKL
SCKL1
WEB: http://www.ncbi.nlm.nih.gov/gene
ATR
ataxia telangiectasia and Rad3 related
545
3q23
9606
3
Official from a nomenclature committee
GO_0000077 (EC: IDA, PMID: 14657349); GO_0001741 (EC: IEA); GO_0003677 (EC: IEA); GO_0004672 (EC: IDA, PMID: 14657349); GO_0004674 (EC: IDA, PMID: 9733515); GO_0005515 (EC: IPI, PMID: 14657349); GO_0005524 (EC: IEA); GO_0005654 (EC: TAS); GO_0005694 (EC: ISS); GO_0006260 (EC: TAS); GO_0006281 (EC: TAS); GO_0006974 (EC: TAS, PMID: 15538388); GO_0007049 (EC: TAS, PMID: 9590286); GO_0007275 (EC: TAS, PMID: 9590286); GO_0008156 (EC: IMP, PMID: 14657349); GO_0016605 (EC: IDA, PMID: 12814551); GO_0018105 (EC: IDA, PMID: 9733515); GO_0032405 (EC: IDA, PMID: 16713580); GO_0032407 (EC: IDA, PMID: 16713580); GO_0034644 (EC: IMP, PMID: 9925639); GO_0042493 (EC: IEA); GO_0043393 (EC: IEA); GO_0043517 (EC: IMP, PMID: 9925639); GO_0046777 (EC: IDA, PMID: 9733515); GO_0071480 (EC: IDA, PMID: 9925639); GO_0090399 (EC: IMP, PMID: 15149599)
PMID: 8610130; 8843195; 8978690; 9427750; 9590286; 9636169; 9733515; 9765199; 9766667; 9857181; 9925639; 10435622; 10545197; 10597277; 10608806; 10673501; 10747897; 10749680; 10859164; 10889046; 10951572; 10973490; 11016625; 11114888; 11163154; 11252893; 11278964; 11390642; 11393670; 11418864; 11459832; 11470508; 11551930; 11673449; 11688760; 11709713; 11715017; 11721054; 11790298; 11799063; 11865061; 11883897; 11927575; 12011431; 12024051; 12147700; 12446774; 12493754; 12519769; 12526805; 12629512; 12640452; 12679521; 12738771; 12766152; 12773400; 12791699; 12791985; 12814551; 12915485; 12959929; 14657349; 14724280; 14729972; 14729973; 14742437; 14755251; 14871897; 14988723; 15050919; 15149599; 15159397; 15195100; 15210935; 15235112; 15279777; 15282542; 15302935; 15314022; 15374968; 15451423; 15456891; 15466211; 15485898; 15496423; 15527801; 15533933; 15538388; 15539948; 15616588; 15635413; 15640246; 15650165; 15650754; 15680327; 15707391; 15734998; 15743907; 15758953; 15775976; 15854902; 15933716; 15987455; 16009130; 16051665; 16086026; 16122425; 16122426; 16195237; 16260606; 16293623; 16306615; 16354571; 16431910; 16436511; 16461339; 16474843; 16488880; 16530042; 16540648; 16675950; 16705183; 16713580; 16738325; 16741947; 16757521; 16827800; 16872911; 16880517; 16909103; 16943440; 16951182; 16956949; 16968694; 17010193; 17015476; 17030982; 17035231; 17118963; 17124492; 17140287; 17148452; 17157788; 17210576; 17260016; 17272271; 17292679; 17376433; 17384638; 17384681; 17409144; 17478428; 17526493; 17616578; 17616665; 17620599; 17638878; 17686975; 17716975; 17879369; 17934520; 17976513; 18003706; 18025301; 18032786; 18160036; 18162465; 18202016; 18245444; 18283122; 18344416; 18357388; 18381943; 18434539; 18451105; 18451257; 18480045; 18495871; 18514189; 18519640; 18536714; 18550533; 18583959; 18625709; 18642075; 18664457; 18757420; 18931676; 18936170; 18950845; 18985806; 18995830; 19004803; 19064565; 19064572; 19074885; 19097996; 19109555; 19116388; 19119425; 19124506; 19146767; 19154794; 19197236; 19242509; 19244116; 19275579; 19275588; 19285939; 19330022; 19351817; 19372558; 19444312; 19470935; 19477925; 19527713; 19536649; 19570909; 19584262; 19586908; 19633697; 19690177; 19714462; 19798433; 19805520; 19828454; 19889979; 19903823; 20005840; 20008788; 20012529; 20029092; 20048340; 20060399; 20084458; 20103595; 20147462; 20233725; 20301772; 20347598; 20368801; 20424596; 20427275; 20427287; 20453000; 20469721; 20496165; 20513533; 20515729; 20566845; 20616048; 20634891; 20731661; 20798688; 20801936; 20810650; 20818375; 20847938; 20861269; 20930849; 21034966; 21139048; 21144835; 21224401; 21242293; 21270107; 21284603; 21285353; 21294646; 21308861; 21383502; 21502314; 21566061; 21659603; 21680529; 21705319; 21857991; 21859891; 21874023; 21890473; 21906983; 21908846; 21963094; 21976111; 21994772; 21995812; 21998596; 22053931; 22084169; 22123827; 22159421; 22174788; 22179839; 22184063; 22341969; 22435685; 22505724; 22535492; 22556425; 22621920; 22713662; 22735644; 22740051; 22797063; 22807682; 22842784; 22939629; 22948311; 23000965; 23029527; 23085754; 23135710; 23144622; 23176708; 23178497; 23255133; 23272087; 23284306; 23345434; 23401567; 23438602; 23447674; 23447702; 23451157; 23454212; 23548269; 23592782; 23592994; 23600770; 23684611; 23696651; 23698467; 23733185; 23807228; 23844225; 23861882; 23873943; 23874235; 23897887; 23901102; 23956138; 24005565; 24045107; 24267891
ataxia telangiectasia and Rad3 related
Ensembl:ENSG00000175054
HGNC:882
HPRD:08369
MIM:601215
Vega:OTTHUMG00000159234
Other designations: FRAP-related protein 1|FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|Rad3 related protein|ataxia telangiectasia and Rad3-related protein|protein kinase ATR|serine/threonine-protein kinase ATR
ATR
Bin Zhao, Yue Liu, Oliver He
BBC2
BCL2L8
WEB: http://www.ncbi.nlm.nih.gov/gene
BAD
BCL2-associated agonist of cell death
572
11q13.1
9606
11
Official from a nomenclature committee
GO_0001836 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10949025); GO_0005543 (EC: IMP); GO_0005739 (EC: IDA); GO_0005741 (EC: IDA); GO_0005741 (EC: TAS); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0006007 (EC: IEA); GO_0006915 (EC: IDA, PMID: 19667065); GO_0006915 (EC: TAS, PMID: 7834748); GO_0006919 (EC: ISS); GO_0007173 (EC: TAS); GO_0008289 (EC: IDA, PMID: 19667065); GO_0008543 (EC: TAS); GO_0008625 (EC: IEA); GO_0008630 (EC: IEA); GO_0008656 (EC: IDA, PMID: 18402937); GO_0009749 (EC: IEA); GO_0010508 (EC: TAS, PMID: 18309324); GO_0010918 (EC: ISS); GO_0019050 (EC: IEA); GO_0019221 (EC: IEA); GO_0019901 (EC: IPI, PMID: 17270021); GO_0030346 (EC: IEA); GO_0032024 (EC: ISS); GO_0032355 (EC: IEA); GO_0032570 (EC: IEA); GO_0033133 (EC: ISS); GO_0033574 (EC: IEA); GO_0034201 (EC: IEA); GO_0035774 (EC: IEA); GO_0038095 (EC: TAS); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0042593 (EC: ISS); GO_0043065 (EC: IDA, PMID: 9388232); GO_0043065 (EC: IMP, PMID: 17289999); GO_0043065 (EC: TAS); GO_0043200 (EC: IEA); GO_0043280 (EC: IDA, PMID: 18402937); GO_0043422 (EC: IEA); GO_0044342 (EC: ISS); GO_0045087 (EC: TAS); GO_0045471 (EC: IEA); GO_0045579 (EC: IEA); GO_0045582 (EC: IEA); GO_0045862 (EC: IDA, PMID: 18387192); GO_0046031 (EC: ISS); GO_0046034 (EC: ISS); GO_0046902 (EC: IMP); GO_0046931 (EC: IDA, PMID: 19667065); GO_0046982 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050679 (EC: IMP, PMID: 19593445); GO_0051384 (EC: IEA); GO_0051592 (EC: IEA); GO_0060139 (EC: IEA); GO_0060154 (EC: IEA); GO_0071247 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071316 (EC: IDA, PMID: 18676776); GO_0071396 (EC: IEA); GO_0071456 (EC: IEP); GO_0090200 (EC: IMP, PMID: 17289999); GO_0097190 (EC: TAS); GO_0097191 (EC: IMP, PMID: 18852119); GO_0097192 (EC: IEA); GO_0097193 (EC: IMP, PMID: 18676776); GO_0097193 (EC: TAS); GO_0097202 (EC: IDA, PMID: 18387192); GO_1900740 (EC: TAS); GO_1901216 (EC: IEA); GO_2000078 (EC: ISS); GO_2001244 (EC: TAS)
PMID: 7834748; 8929531; 8929532; 9130713; 9305851; 9369453; 9381178; 9388232; 9389483; 9463381; 9651683; 9824152; 9878060; 9973195; 10195903; 10381646; 10407019; 10521512; 10558990; 10579309; 10611223; 10620799; 10811615; 10837486; 10837489; 10880354; 10949025; 10949026; 11077446; 11206074; 11278245; 11410287; 11483855; 11494146; 11500364; 11544290; 11583631; 11689886; 11697890; 11717309; 11739707; 11742726; 11781193; 11839683; 11878929; 11908866; 11994280; 12084714; 12087097; 12115603; 12137781; 12239175; 12376548; 12477932; 12657644; 12754297; 12787561; 12842996; 12897128; 12931191; 12954615; 12965220; 14702039; 14767529; 14967141; 15033904; 15078178; 15131699; 15183529; 15226424; 15231831; 15280438; 15489334; 15574335; 15694340; 15705582; 15721256; 15731037; 15751984; 15767261; 15784622; 15849194; 15901741; 15978696; 15990872; 15998799; 16148027; 16189514; 16297499; 16403219; 16413544; 16445909; 16484005; 16603546; 16697956; 16710454; 16728406; 16767165; 16785131; 16843435; 16847055; 16908594; 16932738; 16949642; 16978419; 17011751; 17110373; 17270021; 17274640; 17287851; 17289999; 17393317; 17404594; 17420275; 17438366; 17446862; 17457084; 17474147; 17499381; 17541305; 17544220; 17557568; 17670745; 17696955; 17696989; 17900801; 17927446; 17979178; 18006502; 18029348; 18165867; 18246127; 18276761; 18309324; 18387192; 18391004; 18402774; 18402937; 18420586; 18449891; 18508762; 18508827; 18568448; 18593990; 18628207; 18636124; 18651163; 18651222; 18676776; 18775810; 18798227; 18832722; 18852119; 18973553; 19168699; 19171933; 19508210; 19587239; 19593445; 19624871; 19641507; 19667065; 19679565; 19730683; 19773546; 19882362; 19895838; 19913121; 20012528; 20043968; 20339252; 20596645; 20618440; 20628086; 20647330; 20691103; 20700721; 20810912; 20855536; 20877624; 20936779; 21076048; 21081150; 21187157; 21302807; 21317286; 21419810; 21444773; 21674599; 21849418; 21900206; 21918885; 21988832; 22011203; 22057915; 22096607; 22172950; 22214866; 22423221; 22464442; 22805310; 22837380; 23135712; 23383273; 23547889; 24255178
BCL2-associated agonist of cell death
Ensembl:ENSG00000002330
HGNC:936
HPRD:04409
MIM:603167
Vega:OTTHUMG00000134302
Other designations: BCL-X/BCL-2 binding protein|BCL2-antagonist of cell death protein|BCL2-binding component 6|BCL2-binding protein|bcl-2-binding component 6|bcl-2-like protein 8|bcl-XL/Bcl-2-associated death promoter|bcl2 antagonist of cell death|bcl2-L-8
BAD
Bin Zhao, Yue Liu, Oliver He
BAK
BAK-LIKE
BCL2L7
CDN1
WEB: http://www.ncbi.nlm.nih.gov/gene
BAK1
BCL2-antagonist/killer 1
578
6p21.3
9606
6
Official from a nomenclature committee
GO_0001782 (EC: IEA); GO_0001783 (EC: IEA); GO_0001836 (EC: IDA, PMID: 16199525); GO_0001836 (EC: IGI); GO_0001974 (EC: IEA); GO_0002262 (EC: IEA); GO_0002352 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10381623); GO_0005739 (EC: IDA, PMID: 9843949); GO_0005741 (EC: IBA); GO_0005741 (EC: TAS); GO_0005783 (EC: IEA); GO_0005829 (EC: IEA); GO_0006915 (EC: TAS); GO_0007420 (EC: IEA); GO_0007568 (EC: IEA); GO_0008053 (EC: IEA); GO_0008283 (EC: IEA); GO_0008285 (EC: IEA); GO_0008630 (EC: IBA); GO_0008635 (EC: IEA); GO_0009620 (EC: IEA); GO_0010046 (EC: IEA); GO_0010225 (EC: IEA); GO_0010248 (EC: IDA, PMID: 9843949); GO_0010332 (EC: IEA); GO_0010524 (EC: IEA); GO_0010629 (EC: IEA); GO_0014070 (EC: IEA); GO_0031018 (EC: IEA); GO_0031072 (EC: IEA); GO_0031100 (EC: IEA); GO_0031307 (EC: ISS); GO_0032469 (EC: TAS, PMID: 18309324); GO_0032471 (EC: IEA); GO_0033137 (EC: IEA); GO_0034644 (EC: IMP, PMID: 15901672); GO_0034644 (EC: ISS); GO_0035108 (EC: IEA); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0042802 (EC: IPI, PMID: 15901672); GO_0042803 (EC: IBA); GO_0043065 (EC: IMP, PMID: 17289999); GO_0043496 (EC: IDA, PMID: 9111042); GO_0043497 (EC: IDA, PMID: 9111042); GO_0044346 (EC: IEA); GO_0045471 (EC: IEA); GO_0045862 (EC: IDA, PMID: 18387192); GO_0046872 (EC: IEA); GO_0046902 (EC: IDA); GO_0046930 (EC: IDA, PMID: 9843949); GO_0046982 (EC: IPI, PMID: 10837489); GO_0048597 (EC: IEA); GO_0051087 (EC: IEA); GO_0051400 (EC: IEA); GO_0051726 (EC: IEA); GO_0051881 (EC: IDA, PMID: 9843949); GO_0060068 (EC: IEA); GO_0070059 (EC: IEA); GO_0070242 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0090200 (EC: IEA); GO_0097190 (EC: IMP, PMID: 15901672); GO_0097192 (EC: IBA); GO_0097193 (EC: TAS); GO_0097202 (EC: IDA, PMID: 18387192); GO_1900103 (EC: IMP, PMID: 16645094); GO_1901030 (EC: TAS); GO_1902262 (EC: IEA)
PMID: 7715729; 7715730; 7715731; 8521816; 8887627; 9020082; 9111042; 9463381; 9573342; 9843949; 9878060; 10085290; 10365962; 10381623; 10381646; 10579309; 10639121; 10837489; 10950869; 11175750; 11206074; 11326099; 11571294; 11728179; 11795669; 11867266; 11908704; 11929871; 11932420; 11940658; 11964315; 12070120; 12137781; 12176904; 12297281; 12454021; 12477932; 12624108; 12624178; 12721291; 12808108; 12847083; 12881569; 14574404; 14596824; 14647456; 14702039; 14980220; 15003505; 15077116; 15124764; 15159409; 15194786; 15248898; 15292519; 15322047; 15351796; 15467752; 15478112; 15489334; 15637055; 15638360; 15638362; 15757910; 15846303; 15846589; 15901672; 16172118; 16199525; 16341674; 16376985; 16410245; 16436379; 16439990; 16529740; 16645094; 16712791; 16794010; 16847458; 16874066; 16978419; 16988840; 17015472; 17074758; 17188240; 17227835; 17235284; 17289999; 17353931; 17513609; 17686864; 17698840; 17699158; 17724463; 17879944; 17880809; 17927446; 17991745; 18056640; 18178565; 18251703; 18299329; 18309324; 18349538; 18362892; 18387192; 18413764; 18471982; 18472157; 18524770; 18593893; 18636124; 18665919; 18676680; 18715924; 18927073; 19041633; 19056676; 19060904; 19074885; 19135534; 19148187; 19168699; 19170196; 19255499; 19282307; 19343496; 19351886; 19381065; 19463775; 19481066; 19483681; 19514060; 19587033; 19593445; 19625176; 19692168; 19820697; 19875445; 19898928; 19913121; 19955184; 20034877; 20139978; 20308427; 20428767; 20453000; 20460378; 20503275; 20561923; 20618440; 20628086; 20629644; 20836993; 20855536; 20877624; 20930068; 20959805; 20978950; 21036904; 21041309; 21148306; 21158936; 21159883; 21196599; 21233848; 21613222; 21617256; 21656147; 21658363; 21712378; 21726118; 21727192; 21852253; 21900206; 21988832; 22024133; 22056880; 22065578; 22072546; 22139419; 22188816; 22253918; 22257632; 22297299; 22354970; 22378505; 22423221; 22440942; 22479585; 22493436; 22504646; 22515821; 22526391; 22686245; 22700719; 22719244; 22939629; 23140172; 23189150; 23192964; 23217248; 23229512; 23242420; 23251661; 23263863; 23283967; 23303126; 23389372; 23404709; 23480852; 23604079; 23666239; 23666240; 23770605; 23798675; 23928699; 23954442; 23954445; 23966164; 24026423; 24074954; 24097825; 24100034; 24265320
BCL2-antagonist/killer 1
Ensembl:ENSG00000030110
HGNC:949
HPRD:02744
MIM:600516
Vega:OTTHUMG00000014530
Other designations: BCL2-like 7 protein|apoptosis regulator BAK|bcl-2 homologous antagonist/killer|bcl-2-like protein 7|bcl2-L-7|pro-apoptotic protein BAK
BAK1
Bin Zhao, Yue Liu, Oliver He
BCL2L4
WEB: http://www.ncbi.nlm.nih.gov/gene
BAX
BCL2-associated X protein
581
19q13.3-q13.4
9606
19
Official from a nomenclature committee
GO_0001101 (EC: IEA); GO_0001541 (EC: IEA); GO_0001764 (EC: IEA); GO_0001777 (EC: IEA); GO_0001782 (EC: IEA); GO_0001783 (EC: IDA, PMID: 15214043); GO_0001822 (EC: IEA); GO_0001836 (EC: IDA, PMID: 16199525); GO_0001844 (EC: IEA); GO_0001974 (EC: IEA); GO_0002262 (EC: IEA); GO_0002352 (EC: IEA); GO_0002358 (EC: IEA); GO_0002904 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10753914); GO_0005634 (EC: IMP, PMID: 15102863); GO_0005739 (EC: IDA, PMID: 11912183); GO_0005741 (EC: IBA); GO_0005741 (EC: TAS); GO_0005757 (EC: IDA, PMID: 9843949); GO_0005783 (EC: IDA, PMID: 16424160); GO_0005789 (EC: IDA, PMID: 16424160); GO_0005829 (EC: IDA, PMID: 11912183); GO_0005829 (EC: TAS); GO_0006687 (EC: IEA); GO_0006808 (EC: IEA); GO_0006915 (EC: NAS, PMID: 9920818); GO_0006915 (EC: TAS); GO_0006919 (EC: IDA, PMID: 11912183); GO_0006919 (EC: IMP, PMID: 11350920); GO_0006927 (EC: IMP, PMID: 10739008); GO_0007281 (EC: IEA); GO_0008053 (EC: IDA, PMID: 14769861); GO_0008289 (EC: IDA, PMID: 14522999); GO_0008625 (EC: IC, PMID: 16199525); GO_0008630 (EC: IBA); GO_0008635 (EC: IDA, PMID: 15214043); GO_0008637 (EC: IDA, PMID: 9843949); GO_0009566 (EC: IEA); GO_0009636 (EC: IDA, PMID: 16307838); GO_0009651 (EC: IEA); GO_0010248 (EC: IDA, PMID: 9843949); GO_0010332 (EC: IEA); GO_0015267 (EC: IDA, PMID: 9219694); GO_0016032 (EC: IEA); GO_0021854 (EC: IEA); GO_0021987 (EC: IEA); GO_0030264 (EC: IEA); GO_0032091 (EC: IDA, PMID: 9388232); GO_0032461 (EC: IDA, PMID: 19805544); GO_0032469 (EC: TAS, PMID: 18309324); GO_0032471 (EC: IEA); GO_0032976 (EC: IDA, PMID: 9843949); GO_0033137 (EC: IEA); GO_0033599 (EC: IEA); GO_0034644 (EC: IEA); GO_0035234 (EC: IEA); GO_0042475 (EC: IEA); GO_0042802 (EC: IPI, PMID: 10620504); GO_0042803 (EC: IDA, PMID: 16608847); GO_0042803 (EC: IPI, PMID: 9111042); GO_0043065 (EC: IMP, PMID: 17289999); GO_0043496 (EC: IDA, PMID: 9111042); GO_0043497 (EC: IPI, PMID: 9111042); GO_0043524 (EC: IEA); GO_0043525 (EC: IDA, PMID: 15637643); GO_0043653 (EC: IDA, PMID: 12499352); GO_0045136 (EC: IEA); GO_0046666 (EC: IEA); GO_0046930 (EC: IDA, PMID: 9219694); GO_0046982 (EC: IPI, PMID: 9111042); GO_0048087 (EC: IEA); GO_0048147 (EC: IEA); GO_0048515 (EC: IEA); GO_0048597 (EC: IEA); GO_0048678 (EC: IEA); GO_0048873 (EC: IEA); GO_0051259 (EC: IDA, PMID: 19074440); GO_0051260 (EC: IDA, PMID: 14522999); GO_0051281 (EC: IEA); GO_0051402 (EC: IEA); GO_0051434 (EC: IDA); GO_0051434 (EC: IPI, PMID: 15705586); GO_0051726 (EC: IEA); GO_0051881 (EC: IDA, PMID: 9843949); GO_0060011 (EC: IEA); GO_0060041 (EC: IEA); GO_0060058 (EC: IEA); GO_0060068 (EC: IEA); GO_0070059 (EC: IMP, PMID: 16645094); GO_0070062 (EC: IDA); GO_0070242 (EC: IEA); GO_0071310 (EC: IEA); GO_0072332 (EC: IEA); GO_0090200 (EC: IDA, PMID: 14963330); GO_0097136 (EC: IDA); GO_0097144 (EC: IDA, PMID: 19767770); GO_0097190 (EC: IDA, PMID: 16424160); GO_0097191 (EC: IDA, PMID: 15214043); GO_0097192 (EC: IBA); GO_0097193 (EC: IDA, PMID: 16462759); GO_0097193 (EC: TAS); GO_0097296 (EC: IEA); GO_1900103 (EC: IMP, PMID: 16645094); GO_1901030 (EC: TAS); GO_1902262 (EC: IEA); GO_1902263 (EC: IEA); GO_1902512 (EC: IMP, PMID: 11350920); GO_1990009 (EC: IMP, PMID: 10702418); GO_1990117 (EC: IDA, PMID: 15214043); GO_2001234 (EC: IEA); GO_2001241 (EC: IEA); GO_2001244 (EC: IMP, PMID: 14963330)
PMID: 7566098; 7607685; 7834749; 8358790; 8521816; 8580080; 8760290; 8889548; 8961277; 9020077; 9027312; 9111042; 9130713; 9153240; 9219694; 9372935; 9388232; 9449720; 9463381; 9531611; 9565621; 9742125; 9748162; 9824152; 9843949; 9920818; 9988273; 10200447; 10365962; 10381646; 10437917; 10620504; 10620603; 10620799; 10629050; 10702418; 10716992; 10739008; 10753914; 10772918; 10837489; 10854321; 10908576; 10942389; 11060313; 11106734; 11136736; 11161816; 11175251; 11175336; 11251969; 11259440; 11278245; 11283018; 11350920; 11437653; 11571294; 11574543; 11602639; 11642719; 11742726; 11759059; 11759062; 11782443; 11787859; 11839668; 11839683; 11842081; 11850803; 11850816; 11852106; 11867266; 11869962; 11875499; 11894116; 11899739; 11909872; 11911971; 11912124; 11912183; 11922616; 11929871; 11932420; 11943780; 11949842; 11992551; 11994280; 11997495; 12023951; 12025227; 12032841; 12036888; 12058280; 12070030; 12070120; 12082629; 12137781; 12151395; 12161031; 12165421; 12169275; 12176904; 12189556; 12193163; 12214154; 12215338; 12215842; 12270344; 12359369; 12388688; 12389125; 12393866; 12393884; 12408758; 12419244; 12426317; 12439925; 12445631; 12454021; 12477729; 12477932; 12481899; 12490315; 12496485; 12499352; 12510156; 12575534; 12579342; 12583439; 12592374; 12606781; 12732850; 12737446; 12743423; 12749011; 12767928; 12782632; 12808108; 12816867; 12837286; 12839682; 12853473; 12901880; 12907654; 12917444; 12963997; 12970744; 14522999; 14550297; 14559989; 14596892; 14606101; 14612448; 14612938; 14628086; 14631373; 14634023; 14647416; 14647455; 14661970; 14681224; 14698203; 14704000; 14714449; 14716828; 14719078; 14730312; 14752512; 14766748; 14767525; 14769861; 14963330; 14971737; 14980220; 15024076; 15033690; 15037603; 15073604; 15077116; 15096513; 15102863; 15131699; 15148411; 15149158; 15158440; 15214043; 15231068; 15254227; 15258908; 15262986; 15292938; 15298965; 15302859; 15304079; 15314639; 15322047; 15351796; 15375594; 15375604; 15383280; 15388581; 15459197; 15467752; 15484294; 15489334; 15516208; 15555592; 15574335; 15607964; 15613549; 15637055; 15637643; 15638363; 15642728; 15655830; 15657356; 15688029; 15694358; 15705586; 15710329; 15735127; 15735709; 15743033; 15743760; 15757910; 15764647; 15767261; 15770735; 15773546; 15782132; 15806163; 15830715; 15832769; 15843890; 15846375; 15889622; 15893728; 15901672; 15949439; 15962362; 16009130; 16010425; 16085058; 16113678; 16132718; 16139338; 16148027; 16151013; 16172114; 16172118; 16186627; 16199525; 16215676; 16229013; 16235026; 16246184; 16307023; 16307838; 16344548; 16380996; 16410245; 16424160; 16436379; 16443387; 16462759; 16472763; 16479009; 16485142; 16518869; 16538501; 16552754; 16568093; 16572399; 16575548; 16603637; 16608847; 16611260; 16642033; 16645094; 16709574; 16810067; 16830365; 16832704; 16855163; 16874066; 16946732; 16949642; 16987815; 17007374; 17015472; 17015762; 17052454; 17067385; 17074758; 17084966; 17091766; 17097560; 17107772; 17118768; 17140287; 17171827; 17203183; 17203211; 17213822; 17235284; 17274640; 17289842; 17289999; 17335847; 17346710; 17388661; 17390059; 17395004; 17404017; 17426704; 17438366; 17438390; 17486058; 17494694; 17496930; 17499214; 17509221; 17513609; 17519046; 17525161; 17534116; 17535899; 17556360; 17562177; 17575222; 17626754; 17634542; 17635522; 17635912; 17643375; 17666167; 17668322; 17676485; 17686764; 17693666; 17803695; 17823127; 17855051; 17880809; 17897954; 17900801; 17905238; 17911107; 17912641; 17927446; 17927572; 17978676; 17981213; 17990907; 17993285; 17996028; 17997990; 18006502; 18006817; 18006836; 18019411; 18023359; 18029348; 18034190; 18054155; 18059532; 18074738; 18089567; 18158779; 18160666; 18177350; 18178565; 18193434; 18195012; 18211414; 18214681; 18223689; 18240345; 18251703; 18258596; 18259190; 18259191; 18282575; 18299320; 18299329; 18307410; 18309324; 18331646; 18344566; 18362350; 18362892; 18375382; 18390829; 18395515; 18415681; 18415689; 18445700; 18449500; 18453545; 18454316; 18462830; 18472156; 18472157; 18474606; 18481805; 18494554; 18508723; 18511705; 18534994; 18546202; 18563851; 18568448; 18590739; 18590778; 18594472; 18636124; 18642056; 18644472; 18651163; 18651223; 18664350; 18665919; 18670882; 18676372; 18676680; 18692524; 18695676; 18705408; 18705844; 18718060; 18719392; 18727869; 18772168; 18793611; 18812638; 18813857; 18814044; 18818203; 18818304; 18835031; 18840646; 18925695; 18928586; 18928588; 18936968; 18941118; 18948948; 18973553; 18974096; 18979557; 19031258; 19035131; 19054058; 19056676; 19062087; 19074440; 19074885; 19101510; 19118032; 19125733; 19141860; 19148187; 19150424; 19157504; 19170196; 19177010; 19196429; 19221769; 19228953; 19237173; 19247369; 19265193; 19266703; 19278624; 19319745; 19336552; 19351510; 19360919; 19363595; 19376889; 19380879; 19429011; 19439449; 19439472; 19453261; 19463775; 19475409; 19481066; 19494020; 19541585; 19564333; 19573080; 19587033; 19625176; 19629483; 19636580; 19655415; 19657228; 19660860; 19680558; 19692168; 19692349; 19700502; 19723045; 19729672; 19737817; 19745831; 19767770; 19773279; 19801665; 19805544; 19809877; 19812265; 19846939; 19875445; 19880508; 19888426; 19895710; 19898928; 19913121; 19931389; 19937732; 19938958; 19955813; 19956635; 19968986; 20015862; 20034877; 20045442; 20075864; 20101465; 20114030; 20130137; 20140092; 20180421; 20200776; 20300062; 20308427; 20333643; 20340172; 20346360; 20360684; 20382739; 20404718; 20416158; 20423844; 20431057; 20453000; 20485298; 20490654; 20503275; 20561923; 20565851; 20584903; 20627094; 20628086; 20644561; 20652449; 20683843; 20683914; 20723294; 20723427; 20728382; 20732674; 20803149; 20819778; 20822926; 20850011; 20855536; 20877624; 20929130; 20929131; 20942963; 20959405; 20960177; 20966963; 21029589; 21041309; 21042904; 21048031; 21060336; 21067292; 21069436; 21070973; 21090097; 21104343; 21115898; 21122152; 21123558; 21138867; 21139048; 21148306; 21156403; 21159883; 21173168; 21196320; 21199865; 21223758; 21245196; 21289292; 21367852; 21414921; 21458670; 21483469; 21506333; 21521785; 21530645; 21565982; 21567405; 21597469; 21606679; 21642427; 21642428; 21674599; 21695182; 21706237; 21712378; 21717192; 21725926; 21729540; 21746927; 21751259; 21752397; 21778226; 21785112; 21810274; 21819468; 21847364; 21852238; 21861179; 21862870; 21883444; 21887277; 21890473; 21903925; 21906983; 21907236; 21936009; 21947543; 21949851; 21952639; 21953454; 21978892; 22014978; 22015607; 22037145; 22052011; 22053931; 22056880; 22065578; 22067154; 22072718; 22109662; 22141411; 22159712; 22189282; 22198199; 22201672; 22246181; 22262057; 22277657; 22278385; 22292626; 22297694; 22309278; 22366766; 22418443; 22440942; 22442678; 22479585; 22484496; 22524261; 22526391; 22544745; 22552851; 22560721; 22570867; 22590594; 22629415; 22645134; 22668011; 22675938; 22685558; 22707322; 22710714; 22719244; 22729748; 22732402; 22736223; 22745744; 22748563; 22761420; 22785534; 22852863; 22860893; 22892098; 22906710; 22910913; 22926545; 22949938; 22995373; 23000965; 23038985; 23049480; 23064052; 23088735; 23140172; 23151078; 23151600; 23170075; 23213219; 23220614; 23245210; 23283967; 23289213; 23291169; 23295106; 23297497; 23324193; 23329846; 23334076; 23383273; 23389372; 23392123; 23421021; 23421973; 23442864; 23479508; 23479509; 23487455; 23543151; 23553948; 23562578; 23658815; 23682076; 23744079; 23777485; 23788040; 23824909; 23900080; 23900644; 23907458; 23907941; 23908591; 23966164; 24055994; 24074954; 24100034; 24113173; 24161344; 24200861; 24379070
BCL2-associated X protein
Ensembl:ENSG00000087088
HGNC:959
HPRD:02498
MIM:600040
Vega:OTTHUMG00000160476
Other designations: BCL2-associated X protein omega|BCL2-associated X protein transcript variant delta2|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4
BAX
Bin Zhao, Yue Liu, Oliver He
BCL1
D11S287E
PRAD1
U21B31
WEB: http://www.ncbi.nlm.nih.gov/gene
CCND1
cyclin D1
595
11q13
9606
11
Official from a nomenclature committee
GO_0000082 (EC: IDA, PMID: 19412162); GO_0000082 (EC: TAS, PMID: 18483258); GO_0000122 (EC: IDA, PMID: 16569215); GO_0000278 (EC: TAS); GO_0000307 (EC: IDA, PMID: 17420273); GO_0000320 (EC: IEA); GO_0001889 (EC: IEA); GO_0001934 (EC: IDA, PMID: 8114739); GO_0003714 (EC: IDA, PMID: 16569215); GO_0004672 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15232106); GO_0005622 (EC: IDA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: TAS); GO_0005923 (EC: IEA); GO_0006351 (EC: IEA); GO_0006974 (EC: IDA, PMID: 19412162); GO_0007219 (EC: TAS); GO_0007595 (EC: IEA); GO_0008134 (EC: IPI, PMID: 16569215); GO_0010039 (EC: IEA); GO_0010165 (EC: IEA); GO_0010243 (EC: IEA); GO_0010971 (EC: IDA, PMID: 19124461); GO_0016020 (EC: IEA); GO_0016538 (EC: IEA); GO_0017053 (EC: IDA, PMID: 16569215); GO_0019899 (EC: IPI, PMID: 19412162); GO_0019901 (EC: IPI, PMID: 19124461); GO_0030178 (EC: IEA); GO_0030857 (EC: IEA); GO_0030968 (EC: IEA); GO_0031100 (EC: IEA); GO_0031571 (EC: IDA, PMID: 19412162); GO_0032026 (EC: IEA); GO_0032403 (EC: IEA); GO_0033197 (EC: IEA); GO_0033327 (EC: IEA); GO_0033598 (EC: IEA); GO_0033601 (EC: IEA); GO_0042493 (EC: IEP, PMID: 18291362); GO_0042826 (EC: IPI, PMID: 18417529); GO_0043627 (EC: IEA); GO_0045444 (EC: IEA); GO_0045471 (EC: IEA); GO_0045737 (EC: IDA, PMID: 8114739); GO_0051301 (EC: IEA); GO_0051412 (EC: IEA); GO_0051592 (EC: IEA); GO_0060070 (EC: IEA); GO_0060749 (EC: IEA); GO_0070064 (EC: IDA, PMID: 19124461); GO_0070141 (EC: IDA, PMID: 18483258); GO_0071157 (EC: IDA, PMID: 19124461)
PMID: 1386335; 1532244; 1535701; 1682919; 1826542; 1827756; 1833066; 1833629; 6610211; 7478582; 7568034; 7665234; 7687458; 7733934; 7739547; 7903056; 7908906; 8058338; 8058751; 8101826; 8114739; 8134134; 8136159; 8159685; 8204893; 8208539; 8259215; 8302605; 8490963; 8643455; 8647086; 8657154; 8662825; 8756624; 8826947; 8867812; 8887674; 8978686; 8999999; 9003781; 9039267; 9050835; 9106657; 9139732; 9150368; 9178893; 9190208; 9228064; 9244350; 9311993; 9372967; 9380698; 9426067; 9626345; 9632134; 9661876; 9736735; 9832502; 9832503; 9837900; 9926939; 10066798; 10202152; 10318892; 10344732; 10353443; 10371345; 10486249; 10491434; 10500095; 10580009; 10581175; 10645009; 10764802; 10766840; 10801854; 10850422; 10908655; 10910956; 10952989; 11042687; 11073968; 11076863; 11126356; 11256614; 11279133; 11311237; 11360184; 11470749; 11593423; 11642719; 11696452; 11698342; 11698641; 11739785; 11739795; 11751903; 11788592; 11793365; 11805292; 11813305; 11815623; 11836555; 11838966; 11860939; 11870667; 11872630; 11884610; 11896626; 11902820; 11923474; 11935308; 11940657; 11948404; 11958128; 11986316; 11992406; 12002755; 12006580; 12007188; 12024041; 12036888; 12036906; 12036934; 12036951; 12048199; 12067972; 12096344; 12097293; 12101670; 12127555; 12138206; 12150453; 12151312; 12164325; 12203362; 12209953; 12231535; 12237776; 12241561; 12364325; 12376514; 12379776; 12383116; 12388769; 12391146; 12394763; 12439750; 12444551; 12455063; 12477932; 12480939; 12515730; 12519773; 12529437; 12539042; 12554669; 12557224; 12569141; 12582032; 12589056; 12594215; 12601350; 12606305; 12607604; 12634633; 12673692; 12676926; 12680219; 12692418; 12694349; 12707028; 12738746; 12743597; 12746453; 12759391; 12761882; 12778072; 12807740; 12808109; 12824903; 12825853; 12867429; 12883688; 12883749; 12894561; 12896908; 12899785; 12914697; 12917336; 12917338; 12921950; 12930597; 12937137; 12955092; 12965081; 12972956; 14530270; 14612904; 14641107; 14645506; 14645576; 14646596; 14657069; 14666635; 14666673; 14666699; 14679024; 14688016; 14689059; 14701845; 14703063; 14720512; 14754892; 14759115; 14764597; 14767060; 14966901; 14981950; 15059606; 15060836; 15063389; 15090460; 15128059; 15133490; 15138714; 15153436; 15172998; 15203873; 15225161; 15226187; 15232106; 15239347; 15245939; 15277517; 15282324; 15297421; 15350626; 15355984; 15375804; 15377668; 15378006; 15485920; 15489334; 15489336; 15498584; 15505422; 15513923; 15538282; 15539430; 15544931; 15545188; 15551329; 15557280; 15557752; 15558026; 15578074; 15580291; 15592430; 15621754; 15652748; 15655836; 15659654; 15668481; 15684604; 15688030; 15695117; 15695403; 15709184; 15713663; 15734847; 15735724; 15754315; 15755896; 15776189; 15791567; 15808510; 15809880; 15811121; 15824172; 15845652; 15856299; 15861516; 15862753; 15863141; 15870300; 15878868; 15893730; 15896460; 15897899; 15900590; 15914210; 15923181; 15943036; 15949570; 15950906; 15951302; 15951563; 15971196; 15981100; 16051426; 16061635; 16082198; 16115225; 16123218; 16131791; 16142313; 16155412; 16163549; 16163738; 16166625; 16172916; 16174239; 16207592; 16226824; 16258726; 16258756; 16273238; 16287839; 16322291; 16328437; 16334487; 16341674; 16343742; 16357142; 16381901; 16399423; 16406195; 16407831; 16436505; 16461912; 16488657; 16490596; 16495921; 16507767; 16508013; 16547504; 16552496; 16568089; 16569215; 16600870; 16601140; 16614707; 16614728; 16616093; 16638786; 16644723; 16645724; 16672066; 16690963; 16691558; 16691626; 16699726; 16705174; 16723714; 16732330; 16758952; 16776827; 16782892; 16783567; 16788380; 16804724; 16815198; 16820873; 16829689; 16832876; 16843438; 16860316; 16865250; 16870553; 16884382; 16912209; 16916940; 16924241; 16940298; 16942622; 16959222; 16980615; 16985050; 17011980; 17018901; 17022831; 17046823; 17053782; 17060721; 17067457; 17070615; 17080657; 17081987; 17090192; 17106256; 17116943; 17129455; 17139501; 17188136; 17198740; 17203162; 17203214; 17205132; 17207971; 17208333; 17240151; 17254966; 17274640; 17278098; 17284370; 17299095; 17308274; 17310991; 17316413; 17334399; 17344214; 17374178; 17393422; 17398034; 17409409; 17420273; 17427198; 17437044; 17438373; 17447856; 17482347; 17486065; 17499716; 17509221; 17517369; 17517622; 17524364; 17525627; 17549378; 17556661; 17561354; 17600882; 17605237; 17606477; 17606765; 17607588; 17616526; 17616699; 17626745; 17629555; 17634024; 17653856; 17684142; 17693985; 17695500; 17698033; 17720094; 17724472; 17804732; 17848143; 17855508; 17868090; 17881732; 17882269; 17901853; 17906980; 17908995; 17912028; 17916995; 17922974; 17923265; 17927591; 17927853; 17934069; 17935714; 17941827; 17960397; 18006686; 18006821; 18019405; 18024283; 18027856; 18043898; 18047954; 18056951; 18061526; 18063576; 18067636; 18079202; 18171527; 18174243; 18180298; 18182398; 18187454; 18194492; 18194538; 18196581; 18197291; 18205772; 18212742; 18226366; 18237245; 18239461; 18240019; 18251939; 18281541; 18284543; 18291362; 18301453; 18306932; 18327210; 18327303; 18341653; 18343791; 18347178; 18349267; 18349392; 18355450; 18355918; 18358634; 18361427; 18367547; 18373498; 18379871; 18381935; 18393977; 18398822; 18404250; 18406353; 18413612; 18413728; 18413773; 18413827; 18417529; 18431519; 18437417; 18445313; 18456656; 18459109; 18467434; 18483258; 18483394; 18484097; 18491248; 18507837; 18514338; 18537972; 18547262; 18548202; 18562319; 18598945; 18604165; 18609126; 18616527; 18618300; 18625744; 18632615; 18640142; 18644870; 18650423; 18665038; 18665077; 18676680; 18677114; 18695042; 18695676; 18703151; 18710938; 18710949; 18713830; 18715616; 18715870; 18753363; 18758380; 18769147; 18787961; 18794045; 18794151; 18798551; 18799029; 18819000; 18822177; 18823025; 18829570; 18839518; 18842998; 18843022; 18844221; 18925698; 18936968; 18942117; 18942709; 18949380; 18950845; 18983468; 18988190; 18991334; 19009649; 19020753; 19034659; 19040567; 19047108; 19055446; 19064572; 19070887; 19071090; 19074853; 19074885; 19075005; 19080374; 19084934; 19086036; 19091404; 19096232; 19106611; 19106744; 19116388; 19124461; 19124506; 19129688; 19134409; 19136653; 19139013; 19142864; 19143767; 19147768; 19152247; 19166930; 19170196; 19183483; 19187116; 19203829; 19237565; 19242061; 19258477; 19287456; 19289374; 19302219; 19303206; 19321861; 19322201; 19324500; 19330026; 19336552; 19373442; 19375306; 19379556; 19386349; 19412162; 19415719; 19430707; 19440933; 19443866; 19448414; 19453261; 19467018; 19470470; 19470724; 19474518; 19475398; 19477949; 19489683; 19499154; 19502783; 19505905; 19525979; 19536092; 19538740; 19549773; 19550124; 19554511; 19556892; 19558863; 19564413; 19572978; 19573080; 19575018; 19578796; 19585495; 19589865; 19602458; 19625176; 19633425; 19634112; 19636701; 19638577; 19666237; 19666944; 19670700; 19679881; 19687314; 19690970; 19692168; 19706803; 19723065; 19724860; 19728335; 19738611; 19750108; 19757306; 19760977; 19773279; 19774638; 19779113; 19780858; 19787783; 19789190; 19795398; 19800042; 19801633; 19801969; 19802676; 19806481; 19821490; 19822419; 19823025; 19823825; 19826048; 19850937; 19883431; 19885547; 19898427; 19900369; 19903334; 19904758; 19915615; 19915977; 19917254; 19919588; 19921577; 19923826; 19933579; 19935879; 19940156; 19941161; 19956635; 19956831; 19967453; 20028857; 20062011; 20067552; 20072652; 20087644; 20101207; 20103831; 20113529; 20137349; 20154722; 20160059; 20172376; 20179208; 20181625; 20204303; 20204402; 20231315; 20232305; 20301636; 20304954; 20306448; 20338923; 20347627; 20359085; 20359118; 20372799; 20373052; 20380574; 20389301; 20392877; 20397048; 20401451; 20404095; 20407865; 20418097; 20426528; 20429623; 20437058; 20443083; 20453000; 20453838; 20459741; 20460515; 20466633; 20473525; 20484017; 20485284; 20503270; 20512928; 20515940; 20540739; 20543468; 20564361; 20575692; 20577923; 20578819; 20581865; 20586028; 20616110; 20618968; 20628002; 20631636; 20631637; 20631638; 20644561; 20662834; 20680537; 20680693; 20683026; 20683061; 20683643; 20699365; 20701069; 20714998; 20723296; 20727381; 20737317; 20801098; 20809334; 20822933; 20837141; 20839920; 20844743; 20856207; 20857402; 20890425; 20924203; 20950152; 20951943; 20971731; 21036743; 21042715; 21044962; 21056029; 21062395; 21079973; 21098327; 21107342; 21116504; 21131888; 21135252; 21139048; 21148318; 21159451; 21161398; 21179427; 21185249; 21187402; 21193919; 21200149; 21212260; 21242960; 21242966; 21254295; 21268129; 21273603; 21281227; 21300445; 21315112; 21315488; 21326383; 21327470; 21331989; 21343394; 21347341; 21385053; 21401699; 21410931; 21438905; 21447152; 21454057; 21455311; 21487939; 21492065; 21497295; 21498736; 21503589; 21517236; 21526487; 21537090; 21537837; 21544737; 21547408; 21548803; 21569306; 21594903; 21606015; 21654808; 21738001; 21745168; 21746927; 21777578; 21778791; 21783402; 21789902; 21799732; 21830375; 21850541; 21867613; 21890746; 21892090; 21906983; 21912938; 21946890; 21952639; 21955753; 21956468; 21963094; 21965784; 21972713; 21987572; 21988832; 21989330; 21989926; 22002566; 22024187; 22037875; 22050898; 22052559; 22065993; 22072615; 22100494; 22102309; 22133292; 22135025; 22150974; 22158041; 22204713; 22231956; 22234583; 22260073; 22261253; 22266466; 22289525; 22296356; 22304571; 22306268; 22307325; 22318732; 22321253; 22322158; 22336657; 22357515; 22369110; 22387541; 22391566; 22399638; 22406359; 22406644; 22451658; 22456513; 22460364; 22467101; 22467868; 22475046; 22484283; 22490843; 22528945; 22534667; 22553812; 22565393; 22581837; 22590809; 22606291; 22629227; 22640743; 22647349; 22647378; 22706868; 22707287; 22711989; 22722256; 22747683; 22760121; 22770229; 22776845; 22790016; 22801439; 22812184; 22814742; 22819905; 22833568; 22853846; 22864797; 22884659; 22884800; 22893700; 22901215; 22905217; 22905260; 22922827; 22926658; 22967707; 22976805; 22982899; 23000965; 23001925; 23020291; 23031786; 23044415; 23060014; 23108396; 23111452; 23125009; 23126531; 23135283; 23144465; 23161911; 23163571; 23201130; 23217712; 23222716; 23226276; 23244103; 23255553; 23261678; 23270726; 23292829; 23300886; 23311506; 23315417; 23322406; 23327593; 23354584; 23383003; 23383271; 23388457; 23390492; 23396251; 23400686; 23455922; 23502783; 23515614; 23525507; 23529990; 23540573; 23543735; 23562784; 23566410; 23568005; 23568006; 23613410; 23625206; 23625573; 23648671; 23653001; 23661346; 23664541; 23670132; 23674142; 23696923; 23707388; 23718855; 23720779; 23731275; 23733133; 23737530; 23741361; 23795354; 23804702; 23852369; 23861098; 23864650; 23873109; 23893383; 23897809; 23898488; 23920145; 23936312; 23949314; 23975835; 23985254; 23991960; 23991964; 24019069; 24060591; 24085301; 24088803; 24119401; 24134204; 24145651; 24282282; 24324055; 24403468
cyclin D1
Ensembl:ENSG00000110092
HGNC:1582
HPRD:01346
MIM:168461
Vega:OTTHUMG00000167877
Other designations: B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
CCND1
Bin Zhao, Yue Liu, Oliver He
Bcl-2
PPP1R50
WEB: http://www.ncbi.nlm.nih.gov/gene
BCL2
B-cell CLL/lymphoma 2
596
18q21.3
9606
18
Official from a nomenclature committee
GO_0000209 (EC: IDA, PMID: 16717086); GO_0001101 (EC: IEA); GO_0001503 (EC: IEA); GO_0001541 (EC: IEA); GO_0001656 (EC: IEA); GO_0001658 (EC: IEA); GO_0001662 (EC: IEA); GO_0001782 (EC: IEA); GO_0001836 (EC: ISS, PMID: 9843949); GO_0001836 (EC: NAS, PMID: 9027314); GO_0001952 (EC: IEA); GO_0002020 (EC: IDA, PMID: 10620603); GO_0002320 (EC: IEA); GO_0002326 (EC: IEA); GO_0002931 (EC: IEA); GO_0003014 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10837489); GO_0005634 (EC: IDA, PMID: 7546744); GO_0005737 (EC: IDA, PMID: 11530860); GO_0005739 (EC: IDA, PMID: 7896880); GO_0005741 (EC: IDA, PMID: 8402648); GO_0005741 (EC: TAS); GO_0005783 (EC: IDA, PMID: 8402648); GO_0005789 (EC: IEA); GO_0005829 (EC: IEA); GO_0006470 (EC: IEA); GO_0006582 (EC: IEA); GO_0006808 (EC: IEA); GO_0006915 (EC: TAS); GO_0006959 (EC: TAS, PMID: 1908951); GO_0006974 (EC: IMP, PMID: 17875758); GO_0007015 (EC: IEA); GO_0007409 (EC: IEA); GO_0007565 (EC: NAS, PMID: 11530860); GO_0007569 (EC: IEA); GO_0008134 (EC: IEA); GO_0008219 (EC: IDA, PMID: 36599); GO_0008584 (EC: IEA); GO_0008625 (EC: IDA, PMID: 10597216); GO_0008630 (EC: IBA); GO_0008631 (EC: IEA); GO_0009314 (EC: NAS, PMID: 15799693); GO_0009636 (EC: IDA, PMID: 16307838); GO_0009791 (EC: IEA); GO_0010039 (EC: IDA, PMID: 11264898); GO_0010224 (EC: IEA); GO_0010332 (EC: IEA); GO_0010507 (EC: TAS, PMID: 18309324); GO_0010523 (EC: IEA); GO_0010559 (EC: IEA); GO_0014031 (EC: IEA); GO_0014042 (EC: IEA); GO_0014911 (EC: IEA); GO_0015267 (EC: IDA, PMID: 9219694); GO_0016020 (EC: IDA, PMID: 7896880); GO_0016049 (EC: IEA); GO_0016248 (EC: IDA, PMID: 9219694); GO_0016337 (EC: IEA); GO_0018105 (EC: IEA); GO_0018107 (EC: IEA); GO_0021747 (EC: IEA); GO_0022612 (EC: IEA); GO_0022898 (EC: IDA, PMID: 9219694); GO_0030279 (EC: IEA); GO_0030307 (EC: IDA, PMID: 8022822); GO_0030308 (EC: IEA); GO_0030318 (EC: IEA); GO_0030336 (EC: IEA); GO_0030890 (EC: IMP, PMID: 17875758); GO_0031069 (EC: IEA); GO_0031103 (EC: IEA); GO_0031625 (EC: IPI); GO_0031647 (EC: IEA); GO_0031965 (EC: IDA, PMID: 1502141); GO_0032469 (EC: TAS, PMID: 18309324); GO_0032835 (EC: IEA); GO_0032848 (EC: IDA, PMID: 10506221); GO_0033033 (EC: IEA); GO_0033077 (EC: IEA); GO_0033138 (EC: IEA); GO_0033689 (EC: IEA); GO_0034097 (EC: IDA, PMID: 9184696); GO_0035094 (EC: IDA, PMID: 12421819); GO_0035265 (EC: IEA); GO_0035872 (EC: TAS); GO_0040018 (EC: IEA); GO_0042100 (EC: IDA, PMID: 1373874); GO_0042149 (EC: IEA); GO_0042493 (EC: IDA, PMID: 36599); GO_0042493 (EC: IMP, PMID: 17875758); GO_0042542 (EC: IEA); GO_0042802 (EC: IPI, PMID: 18835031); GO_0042803 (EC: IPI, PMID: 9111042); GO_0043029 (EC: IEA); GO_0043066 (EC: IDA, PMID: 10506221); GO_0043066 (EC: IMP, PMID: 17289999); GO_0043085 (EC: IEA); GO_0043209 (EC: IEA); GO_0043375 (EC: IEA); GO_0043496 (EC: IDA, PMID: 9111042); GO_0043497 (EC: IDA, PMID: 9111042); GO_0043524 (EC: IDA, PMID: 7546744); GO_0043565 (EC: IDA, PMID: 12086670); GO_0043583 (EC: IEA); GO_0045069 (EC: IEA); GO_0045087 (EC: TAS); GO_0045636 (EC: IEA); GO_0045930 (EC: IEA); GO_0046671 (EC: IEA); GO_0046902 (EC: ISS, PMID: 9843949); GO_0046930 (EC: IDA, PMID: 9219694); GO_0046982 (EC: IPI, PMID: 9111042); GO_0048041 (EC: IEA); GO_0048536 (EC: IEA); GO_0048538 (EC: IEA); GO_0048546 (EC: IEA); GO_0048589 (EC: IEA); GO_0048599 (EC: IEA); GO_0048743 (EC: IEA); GO_0048753 (EC: IEA); GO_0048873 (EC: IEA); GO_0050853 (EC: IMP, PMID: 17875758); GO_0051384 (EC: IEA); GO_0051402 (EC: TAS, PMID: 16167175); GO_0051434 (EC: IPI, PMID: 9111042); GO_0051607 (EC: IDA, PMID: 10620603); GO_0051721 (EC: IEA); GO_0051881 (EC: ISS, PMID: 9843949); GO_0051902 (EC: TAS, PMID: 9027314); GO_0051924 (EC: IDA, PMID: 8022822); GO_0055085 (EC: IDA, PMID: 9219694); GO_0070059 (EC: IDA, PMID: 15776018); GO_0071310 (EC: IEA); GO_0071456 (EC: IEA); GO_0072593 (EC: IEA); GO_0097192 (EC: IEA); GO_0097193 (EC: TAS); GO_1900740 (EC: TAS); GO_2000134 (EC: IEA); GO_2000811 (EC: IMP, PMID: 15006356); GO_2001234 (EC: IMP); GO_2001240 (EC: IGI, PMID: 8358790); GO_2001243 (EC: IDA, PMID: 11684014); GO_2001244 (EC: TAS)
PMID: 36599; 1339299; 1373874; 1453000; 1502141; 1508712; 1908951; 2250705; 2834197; 2875799; 3285301; 3523487; 3924412; 7546744; 7579350; 7593193; 7650367; 7753817; 7772249; 7834748; 7896880; 7929424; 7954800; 8022822; 8050499; 8080725; 8090743; 8183370; 8232588; 8358790; 8402618; 8402648; 8551385; 8668206; 8760290; 8790371; 8910675; 8929532; 8949945; 9027314; 9031086; 9070836; 9109491; 9111042; 9115213; 9119086; 9130713; 9184696; 9219694; 9226175; 9226228; 9305631; 9334338; 9389483; 9395403; 9430630; 9449720; 9463381; 9488477; 9525867; 9561195; 9660918; 9668078; 9727491; 9731710; 9738012; 9765397; 9788433; 9843949; 9852076; 9973195; 10072505; 10075695; 10198631; 10217402; 10329560; 10330179; 10354271; 10417825; 10467396; 10490827; 10506221; 10521466; 10567572; 10597216; 10620603; 10620799; 10622714; 10625696; 10669763; 10677502; 10679027; 10716992; 10807576; 10837489; 10848600; 10871848; 10949025; 11054413; 11060313; 11123279; 11126360; 11158204; 11175251; 11181702; 11206074; 11262395; 11264898; 11278245; 11323417; 11325850; 11326318; 11368354; 11390485; 11406564; 11437653; 11463391; 11463392; 11483855; 11495898; 11513873; 11527400; 11530860; 11546872; 11583631; 11642719; 11684014; 11728179; 11752215; 11759059; 11759062; 11774038; 11776759; 11787859; 11790116; 11804283; 11804688; 11815602; 11832478; 11839683; 11855781; 11856759; 11861644; 11864421; 11867266; 11871856; 11877091; 11877266; 11877309; 11877669; 11877670; 11908736; 11914580; 11929874; 11940482; 11948397; 11949842; 11949843; 11956602; 11959101; 11964319; 11971816; 11983915; 11986946; 11988841; 11994280; 11999565; 12000759; 12011972; 12019168; 12025227; 12031912; 12032828; 12032841; 12036852; 12036886; 12036888; 12039864; 12046064; 12054739; 12054916; 12070027; 12082633; 12086670; 12086875; 12095980; 12095993; 12096338; 12101183; 12112824; 12118096; 12133494; 12133517; 12137781; 12140755; 12151395; 12161031; 12162425; 12165497; 12167335; 12170763; 12171774; 12172977; 12174951; 12186923; 12189556; 12197229; 12197771; 12207028; 12209154; 12209955; 12214154; 12215338; 12217802; 12234263; 12270344; 12393707; 12400004; 12404120; 12420213; 12421819; 12431997; 12439925; 12440815; 12452037; 12477721; 12477729; 12477932; 12480939; 12481899; 12488548; 12490308; 12499093; 12510149; 12510191; 12513829; 12515824; 12530303; 12532420; 12533044; 12540563; 12575534; 12579337; 12581249; 12583439; 12613529; 12617962; 12624108; 12629413; 12637332; 12667443; 12670866; 12684626; 12686415; 12694817; 12698366; 12702730; 12720100; 12721288; 12721767; 12722479; 12729794; 12749011; 12751031; 12754350; 12756585; 12759537; 12815463; 12819863; 12821128; 12835724; 12839682; 12853473; 12879322; 12890751; 12890867; 12901880; 12937123; 12938158; 12939460; 12960134; 12960340; 12970736; 13130506; 14519627; 14529662; 14554083; 14555646; 14558950; 14572466; 14612291; 14627346; 14628086; 14631373; 14647416; 14647426; 14660675; 14679209; 14689061; 14698203; 14699151; 14714449; 14724650; 14737118; 14739602; 14754534; 14764541; 14767525; 14769789; 14964781; 14966123; 14971737; 14980220; 14999286; 15006356; 15024706; 15026553; 15033793; 15033825; 15033827; 15034060; 15051039; 15057274; 15061204; 15093750; 15115329; 15123638; 15124764; 15149157; 15149158; 15156398; 15179054; 15196944; 15203866; 15210690; 15225643; 15231068; 15231831; 15233914; 15235941; 15243561; 15245329; 15261486; 15263017; 15274378; 15280201; 15302859; 15303767; 15314290; 15314639; 15329319; 15339676; 15340216; 15344336; 15345651; 15351796; 15353294; 15367432; 15375594; 15467428; 15467450; 15478112; 15484294; 15489334; 15489891; 15492114; 15498929; 15520201; 15528355; 15541642; 15544840; 15545228; 15547950; 15561778; 15563082; 15572421; 15574335; 15577328; 15584904; 15593417; 15605273; 15613488; 15619620; 15633216; 15634885; 15638363; 15657349; 15657350; 15694340; 15716988; 15720412; 15720419; 15733859; 15735709; 15754411; 15757646; 15757977; 15763593; 15776018; 15799693; 15800682; 15803126; 15811121; 15817479; 15826766; 15830715; 15832179; 15832769; 15837573; 15840562; 15849194; 15876860; 15880952; 15889622; 15901672; 15907209; 15911345; 15929186; 15965276; 15981087; 15990872; 16007339; 16010987; 16120388; 16132718; 16133992; 16139338; 16148027; 16166262; 16167175; 16173075; 16181427; 16186627; 16186795; 16194898; 16195370; 16199534; 16204228; 16215670; 16215945; 16227396; 16228292; 16235026; 16243795; 16246184; 16273250; 16307838; 16308474; 16358373; 16434970; 16438077; 16443602; 16463650; 16469847; 16472763; 16479062; 16481323; 16520895; 16530191; 16533178; 16533807; 16538384; 16541314; 16545683; 16550596; 16554306; 16566921; 16568081; 16575548; 16636671; 16638854; 16638864; 16642033; 16648655; 16675913; 16690525; 16697956; 16707568; 16714000; 16717086; 16732934; 16733517; 16735440; 16750039; 16761743; 16777355; 16790527; 16799010; 16820876; 16832704; 16839413; 16840204; 16841088; 16850164; 16855163; 16874461; 16949642; 16950491; 16960146; 16980304; 16982461; 16984978; 16988783; 16998187; 17007374; 17015762; 17050165; 17074584; 17082179; 17090549; 17091766; 17097560; 17118768; 17145812; 17188136; 17191123; 17200714; 17203183; 17207023; 17241114; 17252199; 17259174; 17272502; 17274640; 17289999; 17290286; 17295204; 17301078; 17310847; 17325632; 17356300; 17360176; 17363905; 17372162; 17379544; 17379601; 17384650; 17404013; 17418785; 17426248; 17434928; 17438366; 17439414; 17464868; 17473827; 17507655; 17516030; 17516614; 17534194; 17536310; 17557568; 17561354; 17575222; 17588340; 17616686; 17626754; 17632732; 17652637; 17666167; 17670745; 17675494; 17692808; 17693666; 17701916; 17713095; 17727680; 17785366; 17785460; 17825790; 17848143; 17848408; 17852408; 17875758; 17880809; 17882791; 17893147; 17893875; 17905238; 17908970; 17909067; 17909078; 17912028; 17913397; 17916073; 17920946; 17936584; 17942410; 17957472; 17959858; 17960583; 17978676; 17981569; 17989874; 18006836; 18021997; 18023359; 18026954; 18037229; 18041310; 18046447; 18046449; 18046541; 18055344; 18059532; 18063429; 18069888; 18073527; 18079751; 18091321; 18156504; 18158619; 18160396; 18162459; 18174230; 18178565; 18182854; 18189268; 18199533; 18203018; 18215418; 18220834; 18228020; 18240345; 18248353; 18263880; 18279996; 18309324; 18313386; 18314333; 18327814; 18334006; 18342927; 18343029; 18357521; 18363112; 18367485; 18375822; 18382371; 18386458; 18398703; 18407350; 18410632; 18411730; 18415681; 18415689; 18426731; 18427947; 18428028; 18430249; 18438339; 18450493; 18458532; 18465329; 18468253; 18472157; 18474261; 18478476; 18493992; 18505729; 18508827; 18510726; 18516322; 18516673; 18534064; 18534994; 18538438; 18543286; 18561741; 18566606; 18568671; 18568776; 18568946; 18570871; 18572327; 18573594; 18594472; 18595518; 18622426; 18633450; 18636124; 18651163; 18652313; 18653721; 18657507; 18664350; 18675369; 18687309; 18692524; 18695675; 18695940; 18705844; 18712678; 18719108; 18727869; 18752503; 18758240; 18758641; 18769111; 18769121; 18788571; 18794804; 18806751; 18813857; 18818203; 18835031; 18838868; 18928586; 18928588; 18928590; 18929412; 18940474; 18949393; 18957415; 18983973; 18985814; 18998362; 19002577; 19020723; 19027288; 19035131; 19048366; 19050681; 19058789; 19060592; 19064571; 19074885; 19080514; 19107326; 19107575; 19107861; 19124070; 19138978; 19141121; 19141860; 19152170; 19157504; 19160418; 19168699; 19195736; 19196738; 19205434; 19228691; 19237173; 19238538; 19240654; 19250983; 19253527; 19260506; 19266703; 19269343; 19272801; 19276283; 19280241; 19287190; 19287965; 19298794; 19318089; 19336552; 19348791; 19351510; 19351886; 19360919; 19379569; 19380879; 19385591; 19390575; 19395874; 19398149; 19404232; 19417623; 19429088; 19448593; 19452318; 19453261; 19460716; 19473442; 19475409; 19477129; 19484260; 19495739; 19520430; 19520857; 19521340; 19535347; 19535901; 19537891; 19539330; 19540934; 19541585; 19549844; 19550126; 19556603; 19557638; 19560836; 19573080; 19576799; 19582475; 19585117; 19589501; 19597184; 19602458; 19605509; 19620938; 19625133; 19627536; 19634687; 19636371; 19655415; 19656156; 19664395; 19671677; 19676105; 19706527; 19717648; 19723039; 19723066; 19724860; 19725224; 19730103; 19737931; 19752028; 19762066; 19773279; 19774677; 19774948; 19783718; 19786087; 19789190; 19797069; 19798108; 19805519; 19813621; 19818125; 19823588; 19834492; 19838163; 19846939; 19854241; 19883311; 19890377; 19890662; 19895735; 19908860; 19913121; 19925052; 19931389; 19937732; 19938012; 19938958; 19940548; 19956635; 19968497; 19996270; 20001236; 20010526; 20010695; 20012528; 20023428; 20025478; 20032416; 20034411; 20036222; 20042890; 20045442; 20048149; 20068093; 20072652; 20082279; 20087644; 20090905; 20118770; 20128283; 20132430; 20139069; 20140889; 20142237; 20146885; 20157331; 20160358; 20177797; 20178647; 20180421; 20181625; 20189848; 20189983; 20193114; 20198332; 20200776; 20223826; 20233885; 20237496; 20307495; 20340172; 20350212; 20352431; 20352700; 20368071; 20368567; 20382751; 20392693; 20399529; 20400521; 20401641; 20404322; 20409521; 20411301; 20415745; 20416158; 20423464; 20423844; 20434805; 20442586; 20448381; 20453000; 20459572; 20459695; 20460269; 20468060; 20495005; 20503275; 20504155; 20514538; 20518070; 20530713; 20564216; 20571027; 20584903; 20594261; 20608924; 20610805; 20627094; 20628086; 20631638; 20644561; 20648653; 20652449; 20658730; 20664977; 20668314; 20668552; 20668868; 20683843; 20691103; 20699221; 20716276; 20716950; 20723294; 20723300; 20732674; 20822926; 20836993; 20841355; 20855536; 20865015; 20869096; 20877624; 20885445; 20889974; 20890735; 20929126; 20929130; 20929131; 20936988; 20951945; 20952062; 20959405; 20962079; 20969490; 20976415; 20981461; 21029589; 21060336; 21061795; 21067292; 21068757; 21072044; 21076048; 21090097; 21104343; 21107291; 21108607; 21110823; 21115898; 21117871; 21122152; 21130495; 21131755; 21148306; 21148799; 21151158; 21159314; 21167476; 21171016; 21174060; 21199860; 21203533; 21207420; 21212266; 21223758; 21233846; 21250804; 21258880; 21289092; 21317312; 21320251; 21320534; 21336967; 21358617; 21376256; 21380782; 21385902; 21388911; 21393866; 21412927; 21424069; 21434524; 21442307; 21444675; 21448217; 21454712; 21455217; 21457555; 21463514; 21474673; 21483469; 21506333; 21508398; 21518495; 21543763; 21556123; 21560251; 21560252; 21589877; 21597459; 21618512; 21621926; 21622563; 21624464; 21624955; 21628855; 21640157; 21640710; 21658611; 21659544; 21669575; 21674599; 21680733; 21682651; 21704150; 21706237; 21708043; 21713707; 21717192; 21729540; 21738398; 21748337; 21748764; 21753125; 21771706; 21772052; 21777944; 21778226; 21785112; 21793937; 21808961; 21819468; 21841772; 21850486; 21855110; 21861179; 21868312; 21878650; 21890444; 21901143; 21907236; 21914345; 21933893; 21936874; 21940310; 21949016; 21956116; 21971866; 21971985; 21978692; 21979585; 21988644; 21989054; 22002575; 22014978; 22020994; 22022968; 22024950; 22037714; 22038216; 22038727; 22054286; 22059351; 22065578; 22072615; 22081075; 22097606; 22109662; 22120515; 22121083; 22138435; 22139839; 22143931; 22143957; 22152474; 22160209; 22171982; 22174682; 22174832; 22187149; 22189900; 22194596; 22194861; 22198673; 22199279; 22207524; 22219597; 22252757; 22262057; 22275372; 22275374; 22277792; 22278385; 22285729; 22293115; 22309998; 22320961; 22322190; 22366560; 22366766; 22367371; 22372356; 22393362; 22395507; 22395508; 22395515; 22406486; 22414090; 22418857; 22433870; 22446832; 22462654; 22464442; 22484426; 22504301; 22504646; 22506026; 22517702; 22523079; 22524261; 22532139; 22562364; 22562824; 22563025; 22582499; 22591684; 22619347; 22622204; 22623155; 22629415; 22647378; 22650021; 22666341; 22668011; 22675938; 22684875; 22710204; 22727345; 22732796; 22739157; 22748563; 22749322; 22797576; 22804688; 22842544; 22848417; 22851565; 22855608; 22895528; 22896703; 22926545; 22929980; 22933114; 22936014; 22949148; 22951829; 22953646; 22965228; 22967897; 22968395; 22971934; 22976527; 22990545; 22995373; 23018213; 23030583; 23038985; 23064052; 23065465; 23072837; 23076250; 23091012; 23095743; 23115005; 23119114; 23126236; 23135964; 23138847; 23151078; 23152059; 23153525; 23160675; 23170075; 23174100; 23207618; 23216071; 23235765; 23243017; 23245210; 23247143; 23261425; 23263985; 23272207; 23283967; 23295106; 23301386; 23316052; 23316280; 23324193; 23334076; 23335369; 23341456; 23352961; 23355004; 23358890; 23359021; 23359184; 23363601; 23364242; 23364875; 23369735; 23403511; 23417836; 23421973; 23422486; 23437205; 23449635; 23463292; 23471820; 23479508; 23479509; 23480852; 23494176; 23497522; 23504944; 23509938; 23511489; 23514940; 23527542; 23553948; 23564079; 23568006; 23573235; 23588221; 23610963; 23612742; 23613399; 23613627; 23624503; 23628417; 23637776; 23671559; 23673452; 23673926; 23674504; 23688426; 23708869; 23719266; 23722017; 23724505; 23733877; 23770605; 23784204; 23802633; 23812727; 23818364; 23822101; 23832737; 23846229; 23850692; 23851330; 23861345; 23880928; 23900644; 23906301; 23907579; 23939148; 23960074; 23975374; 23991978; 23991993; 23994555; 24048795; 24091677; 24097825; 24127568; 24141421; 24157866; 24240096; 24256571; 24288815; 24293274; 24299314; 24314632; 24395794
B-cell CLL/lymphoma 2
Ensembl:ENSG00000171791
HGNC:990
HPRD:01045
MIM:151430
Other designations: apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
BCL2
Bin Zhao, Yue Liu, Oliver He
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
WEB: http://www.ncbi.nlm.nih.gov/gene
BCL2A1
BCL2-related protein A1
597
15q24.3
20140408
9606
15
protein-coding
Official from a nomenclature committee
GO_0005515 (EC: IPI, PMID: 10753914); GO_0005741 (EC: IBA); GO_0008630 (EC: IBA); GO_0042803 (EC: IBA); GO_0043066 (EC: IBA); GO_0046982 (EC: IBA); GO_0051400 (EC: IEA); GO_0097192 (EC: IBA); GO_2001243 (EC: IBA)
PMID: 7478596; 8345191; 8589678; 8605321; 8910286; 8952545; 9050999; 9321477; 9356461; 9670936; 9731710; 10049353; 10198631; 10381646; 10430908; 10454539; 10545479; 10753914; 10849436; 11329013; 11483855; 11696595; 11929871; 12477932; 12665576; 12692420; 12771180; 14747545; 14966372; 14981542; 15489334; 15499630; 15501771; 15592513; 15617521; 15694340; 15696550; 16164629; 16551634; 16572199; 16697956; 16873269; 17121585; 17666431; 17724464; 17726463; 17907802; 17942758; 18093280; 18206119; 18414982; 18512730; 18812174; 18835031; 19336552; 19573080; 19759007; 19773279; 19913121; 20185581; 20353833; 20628086; 20800603; 20855536; 21167304; 21491422; 21832049; 21843371; 22231730; 22292048; 22510878; 22553204; 22615379; 22720045; 22745672; 22865454; 23118966; 23152563; 23447565
BCL2-related protein A1
Ensembl:ENSG00000140379
HGNC:991
HPRD:03034
MIM:601056
Vega:OTTHUMG00000144173
Other designations: bcl-2-like protein 5|bcl-2-related protein A1|bcl2-L-5|hematopoietic BCL2-related protein A1|hemopoietic-specific early response protein|protein BFL-1
BCL2A1
Bin Zhao, Yue Liu, Oliver He
BCL4
D19S37
WEB: http://www.ncbi.nlm.nih.gov/gene
BCL3
B-cell CLL/lymphoma 3
602
19q13.1-q13.2
9606
19
Official from a nomenclature committee
GO_0000060 (EC: IMP, PMID: 16280327); GO_0002268 (EC: IEA); GO_0002315 (EC: IEA); GO_0002455 (EC: IEA); GO_0002467 (EC: IEA); GO_0003677 (EC: IEA); GO_0003700 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10362352); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006351 (EC: IDA, PMID: 16306601); GO_0006974 (EC: IDA, PMID: 16384933); GO_0007249 (EC: IDA, PMID: 8196632); GO_0008134 (EC: IPI, PMID: 11387332); GO_0009615 (EC: IDA, PMID: 16306601); GO_0010225 (EC: IDA, PMID: 16384933); GO_0019730 (EC: IEA); GO_0030198 (EC: IEA); GO_0030330 (EC: IMP, PMID: 16384933); GO_0030674 (EC: TAS, PMID: 16306601); GO_0032729 (EC: IEA); GO_0032996 (EC: IDA, PMID: 16280327); GO_0033257 (EC: IDA, PMID: 9407099); GO_0042088 (EC: IEA); GO_0042345 (EC: IEP, PMID: 8196632); GO_0042536 (EC: IEA); GO_0042742 (EC: IEA); GO_0042771 (EC: IMP, PMID: 16384933); GO_0042832 (EC: IEA); GO_0042981 (EC: IDA, PMID: 16732314); GO_0043066 (EC: IDA, PMID: 16384933); GO_0043234 (EC: IDA, PMID: 16280327); GO_0045064 (EC: IEA); GO_0045082 (EC: IEA); GO_0045171 (EC: IDA); GO_0045415 (EC: IMP, PMID: 16306601); GO_0045727 (EC: IMP, PMID: 16384933); GO_0045892 (EC: IDA, PMID: 16306601); GO_0045893 (EC: IDA, PMID: 16384933); GO_0045944 (EC: IEA); GO_0048471 (EC: IEA); GO_0048536 (EC: IEA); GO_0051101 (EC: IEP, PMID: 9407099); GO_0051457 (EC: NAS, PMID: 8196632)
PMID: 1406939; 1501714; 1923524; 2124350; 2180580; 7691160; 7896265; 8196632; 8330739; 8428580; 8453667; 8497270; 9218802; 9407099; 9576921; 9812988; 10362352; 10469655; 10497212; 10607713; 11387332; 11485202; 11707390; 12456498; 12477932; 12730195; 12808109; 14678988; 15105810; 15469820; 15489334; 15634875; 15829968; 16099425; 16108830; 16123212; 16280327; 16306601; 16311697; 16331275; 16384933; 16732314; 16940298; 17272867; 17495977; 17644518; 17881446; 17923499; 17962807; 17963943; 18025803; 18796561; 18940474; 19191868; 19229118; 19282837; 19383626; 19451226; 19494302; 19617629; 19806201; 19893491; 19913121; 20226764; 20414006; 20471052; 20547759; 20558726; 20572854; 20601676; 20634891; 20658525; 20672350; 20731879; 20737317; 20800578; 20974051; 21048031; 21912613; 21988832; 22580608; 22782967; 23115114; 23149915; 23494744; 23534762; 23565137; 23607276; 23669365; 23794716
B-cell CLL/lymphoma 3
Ensembl:ENSG00000069399
HGNC:998
HPRD:00179
MIM:109560
Vega:OTTHUMG00000151517
Other designations: B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3
BCL3
Bin Zhao, Yue Liu, Oliver He
BHMT1
HEL-S-61p
WEB: http://www.ncbi.nlm.nih.gov/gene
BHMT
betaine--homocysteine S-methyltransferase
635
5q14.1
9606
5
Official from a nomenclature committee
GO_0000096 (EC: TAS); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006479 (EC: NAS, PMID: 10075673); GO_0006579 (EC: IEA); GO_0008270 (EC: IEA); GO_0008898 (EC: IEA); GO_0009086 (EC: IEA); GO_0010243 (EC: IEA); GO_0032403 (EC: IEA); GO_0034641 (EC: TAS); GO_0043234 (EC: IEA); GO_0044281 (EC: TAS); GO_0047150 (EC: NAS, PMID: 10075673); GO_0047150 (EC: TAS); GO_0050666 (EC: NAS, PMID: 10075673)
PMID: 1657504; 8798461; 8889548; 9281325; 9681996; 10075673; 10529246; 11223523; 11516176; 11883905; 12071701; 12220488; 12475213; 12477932; 12749058; 12818402; 15122900; 15489334; 16189514; 16344560; 16816108; 16953798; 17035141; 17119116; 17376725; 17436311; 17705221; 17993766; 18000879; 18029348; 18230680; 18262489; 18427977; 18457970; 18498552; 18635682; 18676680; 18708404; 18830263; 18988749; 19048631; 19161160; 19170196; 19336437; 19493349; 19625176; 19635752; 19683694; 19692168; 19737740; 19777601; 19913121; 19936946; 19948975; 20031554; 20346360; 20453000; 20458436; 20628086; 20634891; 20662904; 20664391; 20737570; 21093336; 21349258; 21564312; 21565678; 21630102; 21988832; 22138536; 22339686; 22339736; 23378610; 23645037; 23720494
betaine--homocysteine S-methyltransferase
Ensembl:ENSG00000145692
HGNC:1047
HPRD:04200
MIM:602888
Vega:OTTHUMG00000108157
Other designations: betaine--homocysteine S-methyltransferase 1|epididymis secretory sperm binding protein Li 61p
BHMT
Bin Zhao, Yue Liu, Oliver He
FP497
WEB: http://www.ncbi.nlm.nih.gov/gene
BID
BH3 interacting domain death agonist
637
22q11.1
9606
22
Official from a nomenclature committee
GO_0001836 (EC: IDA, PMID: 17052454); GO_0005123 (EC: TAS, PMID: 8918887); GO_0005515 (EC: IPI, PMID: 12624108); GO_0005739 (EC: TAS, PMID: 9727491); GO_0005741 (EC: TAS); GO_0005829 (EC: TAS); GO_0006626 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IEA); GO_0007420 (EC: IEA); GO_0008625 (EC: TAS, PMID: 9727491); GO_0008637 (EC: TAS, PMID: 9727492); GO_0016020 (EC: TAS, PMID: 8918887); GO_0031625 (EC: IEA); GO_0032355 (EC: IEA); GO_0032461 (EC: IDA, PMID: 19074440); GO_0032464 (EC: IDA); GO_0032592 (EC: IEA); GO_0034349 (EC: IEA); GO_0042127 (EC: IEA); GO_0042770 (EC: TAS, PMID: 18309324); GO_0043065 (EC: IMP, PMID: 17289999); GO_0051260 (EC: IEA); GO_0051402 (EC: TAS, PMID: 16167175); GO_0090150 (EC: IDA); GO_0090200 (EC: IGI); GO_0090200 (EC: IMP, PMID: 17289999); GO_0097193 (EC: TAS); GO_1900740 (EC: TAS); GO_1901030 (EC: TAS); GO_1902108 (EC: IEA); GO_2000045 (EC: IEA); GO_2001238 (EC: IMP); GO_2001244 (EC: TAS)
PMID: 7774948; 7929347; 8918887; 9463381; 9721221; 9727491; 9727492; 9790773; 10089877; 10364179; 10629050; 10950869; 11085743; 11099414; 11114298; 11399776; 11544326; 11583622; 11583631; 11585909; 11741882; 11790791; 11805084; 11832478; 11929871; 11940658; 11971973; 12000759; 12061801; 12097160; 12193163; 12196516; 12404116; 12419244; 12477932; 12598529; 12624108; 12754217; 12766488; 12804595; 12808108; 12871587; 12934063; 14581476; 14583606; 14702039; 14716828; 14769944; 15024076; 15117953; 15123718; 15146197; 15173176; 15231831; 15323553; 15353804; 15461802; 15489334; 15501827; 15520201; 15574335; 15592455; 15615731; 15637055; 15659383; 15692567; 15694340; 15721256; 15772077; 15809076; 16077201; 16167175; 16172118; 16341674; 16344560; 16380381; 16475813; 16485030; 16697956; 16908521; 16964285; 16987815; 17052454; 17200714; 17226776; 17283187; 17289999; 17308307; 17431792; 17488272; 17534194; 17549073; 17635912; 17666167; 17762183; 17765974; 17855051; 18029348; 18089817; 18165867; 18166654; 18173728; 18195012; 18297401; 18309324; 18317451; 18373075; 18469004; 18593990; 18648372; 18665919; 18723680; 18838202; 18925930; 19029793; 19046991; 19052714; 19074440; 19074885; 19219602; 19233849; 19246452; 19381674; 19423537; 19454696; 19640637; 19641510; 19670908; 19711428; 19820711; 19890662; 19913121; 19918914; 19929986; 20140092; 20187936; 20356928; 20379614; 20392206; 20404718; 20453000; 20628086; 20801175; 20802294; 20855536; 20877624; 21041309; 21060336; 21072056; 21113148; 21139048; 21148306; 21178828; 21223573; 21367852; 21382479; 21613222; 21642428; 21751259; 21856753; 21859891; 21900206; 21906983; 22052011; 22115752; 22130162; 22189507; 22213163; 22246181; 22339673; 22354970; 22393005; 22416135; 22464442; 22860893; 22939629; 22964611; 23019260; 23192964; 23333919; 23352961; 23383273; 23418437; 23604079; 23744079; 23824909; 24074954; 24158446
BH3 interacting domain death agonist
Ensembl:ENSG00000015475
HGNC:1050
HPRD:03590
MIM:601997
Vega:OTTHUMG00000150087
Other designations: BH3-interacting domain death agonist|BID isoform ES(1b)|BID isoform L(2)|BID isoform Si6|Human BID coding sequence|apoptic death agonist|desmocollin type 4|p22 BID
BID
Bin Zhao, Yue Liu, Oliver He
BLIMP1
PRDI-BF1
WEB: http://www.ncbi.nlm.nih.gov/gene
PRDM1
PR domain containing 1, with ZNF domain
639
RP1-134E15.1
6q21
9606
6
Official from a nomenclature committee
GO_0000122 (EC: IEA); GO_0001893 (EC: IEA); GO_0003700 (EC: TAS, PMID: 1851123); GO_0005515 (EC: IPI); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0006351 (EC: IEA); GO_0007281 (EC: IEA); GO_0008168 (EC: IEA); GO_0010628 (EC: IEA); GO_0030889 (EC: IEA); GO_0031665 (EC: IEA); GO_0042462 (EC: IEA); GO_0042826 (EC: IEA); GO_0043565 (EC: IEA); GO_0045165 (EC: IEA); GO_0045579 (EC: IEA); GO_0046872 (EC: IEA); GO_0060707 (EC: IEA)
PMID: 1851123; 8033216; 8168136; 8921366; 9887105; 10713181; 11067898; 11342629; 11877292; 12150891; 12165517; 12453881; 12477932; 12626569; 14985713; 16002735; 16424392; 16492805; 16547239; 16585013; 16699504; 16713569; 16765445; 16849320; 17043021; 17213024; 17264218; 17379744; 17682124; 17877160; 18071884; 18089822; 18192112; 18235046; 18256039; 18354204; 18370921; 18400362; 18552212; 18583325; 18596541; 18604866; 18845144; 18992153; 19047678; 19124609; 19194464; 19234190; 19269192; 19322201; 19433448; 19460752; 19530237; 19563034; 19717648; 19735688; 19760754; 19788443; 19828629; 19828640; 19838193; 19838195; 19898481; 19915048; 20047096; 20379614; 20530581; 20800019; 20859709; 20944005; 20966935; 21102463; 21103670; 21216962; 21411757; 21622776; 21690554; 21722313; 21722636; 21785431; 22020966; 22040493; 22143801; 22278826; 22438909; 22555612; 22580854; 22585398; 22593617; 22634616; 22939624; 23028907; 23129528; 23273568; 23348703; 23624108; 23648065; 23911415; 24004669; 24009228
PR domain containing 1, with ZNF domain
Ensembl:ENSG00000057657
HGNC:9346
HPRD:04572
MIM:603423
Vega:OTTHUMG00000015299
Other designations: B-lymphocyte-induced maturation protein 1|BLIMP-1|PR domain zinc finger protein 1|PRDI-binding factor-1|beta-interferon gene positive-regulatory domain I binding factor
PRDM1
Bin Zhao, Yue Liu, Oliver He
CA-II
CAC
CAII
Car2
HEL-76
WEB: http://www.ncbi.nlm.nih.gov/gene
CA2
carbonic anhydrase II
760
8q22
9606
8
Official from a nomenclature committee
GO_0001822 (EC: IEA); GO_0002009 (EC: IEA); GO_0004089 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15990874); GO_0005615 (EC: IEA); GO_0005737 (EC: IDA, PMID: 114507); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 15990874); GO_0005902 (EC: IEA); GO_0006730 (EC: IEA); GO_0008270 (EC: IDA, PMID: 3151020); GO_0009268 (EC: IEA); GO_0010043 (EC: IEA); GO_0015670 (EC: IEA); GO_0015701 (EC: TAS); GO_0016323 (EC: IEA); GO_0030424 (EC: IEA); GO_0032849 (EC: IEA); GO_0038166 (EC: IDA, PMID: 15990874); GO_0042475 (EC: IEA); GO_0043627 (EC: IEA); GO_0044070 (EC: IDA, PMID: 15990874); GO_0044281 (EC: TAS); GO_0045177 (EC: IDA, PMID: 14675051); GO_0045672 (EC: IEA); GO_0045780 (EC: IEA); GO_0046903 (EC: IEA); GO_0051453 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867); GO_2001150 (EC: ISS)
PMID: 114507; 823150; 1301935; 1542674; 1602151; 1925679; 1928091; 1977133; 2117271; 2121671; 2123360; 2850697; 3000449; 3081869; 3107918; 3108857; 3121496; 3151019; 3151020; 3221988; 3925334; 4207120; 4621826; 4624444; 6407977; 6817747; 7574487; 7627193; 7930522; 8127074; 8128957; 8460098; 8834238; 9143915; 9150731; 9205766; 9336790; 9453381; 9541386; 9774471; 9890926; 10231836; 10333352; 10423017; 10811634; 10820026; 10821857; 11063570; 11076507; 11264157; 11457932; 11606574; 11956656; 12056894; 12138085; 12171926; 12411514; 12477932; 12501217; 12566520; 12826902; 12933803; 14567693; 14578124; 14675051; 14675565; 14718574; 14736710; 14760703; 15049705; 15062553; 15218065; 15300855; 15453828; 15489334; 15667203; 15836783; 15837316; 15837325; 15952740; 15990874; 16106378; 16169070; 16196087; 16265785; 16344560; 16475831; 16687407; 16825953; 16996812; 17202139; 17319692; 17319695; 17363915; 17631639; 17881426; 18029348; 18060825; 18083150; 18189416; 18247480; 18323598; 18539591; 18580434; 18942852; 18976975; 19012038; 19034380; 19056867; 19269136; 19371798; 19407386; 19415900; 19520834; 19583303; 19615732; 19634894; 19686046; 20000378; 20025241; 20081808; 20170095; 20297840; 20360068; 20398423; 20445237; 20445238; 20509747; 20578724; 20634585; 20637176; 20693695; 20849852; 21139048; 21145461; 21145876; 21243755; 21282642; 21543742; 21680735; 21890473; 21988105; 22001224; 22192857; 22386980; 22416960; 22732064; 22878862; 23030313; 23098192; 23181366; 23215152; 23360090; 23674848; 23720494; 23727877; 23953824; 24036123
carbonic anhydrase II
Ensembl:ENSG00000104267
HGNC:1373
HPRD:02023
MIM:611492
Vega:OTTHUMG00000164944
Other designations: carbonate dehydratase II|carbonic anhydrase 2|carbonic anhydrase B|carbonic anhydrase C|carbonic dehydratase|epididymis luminal protein 76
CA2
Bin Zhao, Yue Liu, Oliver He
CAXII
HsT18816
WEB: http://www.ncbi.nlm.nih.gov/gene
CA12
carbonic anhydrase XII
771
15q22
9606
15
Official from a nomenclature committee
GO_0004089 (EC: IEA); GO_0005886 (EC: TAS); GO_0006730 (EC: IEA); GO_0008270 (EC: IEA); GO_0015701 (EC: TAS); GO_0016021 (EC: IEA); GO_0044281 (EC: TAS)
PMID: 8524854; 9636197; 9770531; 10512682; 10611263; 10666387; 11083462; 11101628; 11238049; 11420383; 11493685; 11680594; 12477932; 12676895; 12854129; 12923247; 14578124; 14702039; 15489334; 15849821; 16169070; 16416108; 18029348; 18322268; 18336315; 18451179; 19291313; 20132413; 20215053; 20398423; 20434230; 20509747; 21035102; 21040567; 21139048; 21184099; 21278619; 21900206; 22172588; 22439015; 22944692; 23348702
carbonic anhydrase XII
HGNC:1371
HPRD:04464
MIM:603263
Other designations: CA-XII|carbonate dehydratase XII|carbonic anhydrase 12|carbonic dehydratase|tumor antigen HOM-RCC-3.1.3
CA12
Bin Zhao, Yue Liu, Oliver He
CAB1
CACNLB1
CCHLB1
WEB: http://www.ncbi.nlm.nih.gov/gene
CACNB1
calcium channel, voltage-dependent, beta 1 subunit
782
17q21-q22
9606
17
Official from a nomenclature committee
GO_0005245 (EC: TAS, PMID: 1385409); GO_0005891 (EC: IEA); GO_0006612 (EC: IEA); GO_0006810 (EC: TAS, PMID: 1385409); GO_0007411 (EC: TAS); GO_0008331 (EC: IEA); GO_0016529 (EC: IEA); GO_0030315 (EC: IEA)
PMID: 1309651; 1370480; 1385409; 1657644; 7916667; 8381767; 8395940; 8905728; 8943043; 10066897; 10465427; 10624822; 12477932; 14623965; 14760703; 14762176; 15342556; 16713569; 17081983; 19821165; 19953087; 21098446; 21832049; 21906983; 23382691; 23602568
calcium channel, voltage-dependent, beta 1 subunit
Ensembl:ENSG00000067191
HGNC:1401
HPRD:11743
MIM:114207
Vega:OTTHUMG00000133217
Other designations: calcium channel voltage-dependent subunit beta 1|calcium channel, L type, beta 1 polypeptide|dihydropyridine-sensitive L-type, calcium channel beta-1 subunit|voltage-dependent L-type calcium channel subunit beta-1
CACNB1
Bin Zhao, Yue Liu, Oliver He
CAC
CACT
WEB: http://www.ncbi.nlm.nih.gov/gene
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
788
3p21.31
9606
3
Official from a nomenclature committee
GO_0005739 (EC: IDA); GO_0005743 (EC: TAS); GO_0006853 (EC: TAS); GO_0016021 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS)
PMID: 1598097; 9399886; 9533014; 9686371; 9733094; 9837782; 10384384; 10697964; 11257506; 11592821; 12477932; 12859414; 15057979; 15365988; 15489334; 15515015; 16054041; 16169070; 17508264; 18029348; 18307102; 19748481; 20877624; 21130740; 21890473; 22560224; 23178685; 23266187; 23322164
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
Ensembl:ENSG00000178537
HGNC:1421
HPRD:01953
MIM:613698
Vega:OTTHUMG00000133538
Other designations: mitochondrial carnitine/acylcarnitine carrier protein
SLC25A20
Bin Zhao, Yue Liu, Oliver He
ICE
IL1BC
P45
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP1
caspase 1, apoptosis-related cysteine peptidase
834
11q23
9606
11
GO_0001666 (EC: IEA); GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID:11374873); GO_0005576 (EC: IEA); GO_0005737 (EC: IBA); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID:12888622); GO_0006915 (EC: TAS, PMID:7876192); GO_0006919 (EC: TAS, PMID:10799503); GO_0007165 (EC: TAS, PMID:1373520); GO_0008656 (EC: TAS, PMID:10799503); GO_0032496 (EC: IEA); GO_0032611 (EC: IEA); GO_0033198 (EC: IEA); GO_0035872 (EC: TAS); GO_0043123 (EC: IEP, PMID:12761501); GO_0045087 (EC: TAS); GO_0050717 (EC: IEA); GO_0050718 (EC: IEA); GO_0050727 (EC: IBA); GO_0051882 (EC: IEA); GO_0060081 (EC: IEA); GO_0070269 (EC: IEA); GO_0071260 (EC: IEP, PMID:19593445); GO_0071310 (EC: IDA, PMID:19158679); GO_0072557 (EC: IBA); GO_0072557 (EC: ISS); GO_0072558 (EC: IDA, PMID:12191486); GO_0072559 (EC: IDA, PMID:15030775); GO_0097169 (EC: IDA, PMID:19158676); GO_0097194 (EC: IBA)
PMID:1321594; 1373520; 1574116; 1919001; 7642516; 7721861; 7797510; 7876192; 8034320; 8035875; 8044845; 8125298; 8861900; 8962078; 8978814; 8999548; 9002959; 9070648; 9115219; 9190289; 9219695; 9250871; 9334240; 9334338; 9435230; 9535906; 9548463; 9593687; 9632733; 9705209; 9705938; 9727491; 9792675; 9804161; 9830039; 9875225; 9894612; 9987822; 9990034; 10069390; 10329646; 10353249; 10438581; 10477277; 10510468; 10660263; 10708425; 10799503; 11085743; 11226410; 11374873; 11390368; 11432859; 11437653; 11438643; 11472070; 11536016; 11684016; 11821383; 11953316; 11967258; 11997061; 12019269; 12096920; 12170183; 12191486; 12215842; 12387869; 12459189; 12459463; 12477932; 12628757; 12692130; 12761501; 12888622; 14584052; 14669344; 15030775; 15039421; 15107016; 15296730; 15326478; 15383541; 15471361; 15489334; 15498465; 15561713; 15749123; 15809717; 16037825; 16087165; 16123779; 16260731; 16286016; 16405550; 16428475; 16575408; 16621994; 16778130; 16780720; 16785446; 16817903; 16903774; 16920334; 17036048; 17173859; 17196042; 17207965; 17303764; 17360653; 17418785; 17477815; 17597823; 17623017; 17703412; 17959595; 18029348; 18209072; 18263705; 18263805; 18304957; 18329368; 18523309; 18550243; 18577712; 18590738; 18799371; 18828051; 18981155; 19013323; 19074885; 19117953; 19141860; 19158676; 19158679; 19258923; 19269008; 19275586; 19382257; 19414860; 19439663; 19573080; 19593445; 19648107; 19737897; 19773279; 19779610; 19825518; 19833722; 19913121; 20038581; 20048342; 20060974; 20170165; 20184726; 20197547; 20402676; 20485444; 20503287; 20628086; 20808838; 20852925; 20855536; 20959405; 21037509; 21048031; 21052690; 21311905; 21320026; 21463955; 21757759; 21792841; 21832064; 21862576; 21862623; 22046355; 22046441; 22195745; 22227487; 22491736; 22537218; 22833538; 22837397; 23021143; 23209292; 23226468; 23236067; 23278288; 23386603; 23508996; 23590971; 23637985; 23703390; 23793845; 23839215; 23884363; 24022484; 24356306
caspase 1, apoptosis-related cysteine peptidase
Ensembl:ENSG00000137752
HGNC:1499
HPRD:00977
MIM:147678
Vega:OTTHUMG00000048072
Other designations: CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
CASP1
Bin Zhao, Yue Liu, Oliver He
CASP-2
ICH1
NEDD-2
NEDD2
PPP1R57
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP2
caspase 2, apoptosis-related cysteine peptidase
835
7q34-q35
9606
7
GO_0001554 (EC: IEA); GO_0003407 (EC: IEA); GO_0004197 (EC: IDA, PMID:10980123); GO_0005515 (EC: IPI, PMID:11076957); GO_0005634 (EC: TAS, PMID:18309324); GO_0005737 (EC: IBA); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006915 (EC: NAS, PMID:11156409); GO_0006977 (EC: IMP); GO_0007420 (EC: IEA); GO_0007568 (EC: IEA); GO_0008630 (EC: IBA); GO_0008630 (EC: TAS, PMID:18309324); GO_0016020 (EC: IEA); GO_0016485 (EC: IDA, PMID:9044836); GO_0019899 (EC: ISS, PMID:11076957); GO_0019904 (EC: IPI, PMID:9044836); GO_0035234 (EC: IEA); GO_0043065 (EC: IDA, PMID:10980123); GO_0043281 (EC: TAS); GO_0043525 (EC: IEA); GO_0048011 (EC: TAS); GO_0071260 (EC: IEP, PMID:19593445); GO_0097153 (EC: IEA); GO_0097190 (EC: TAS, PMID:18309324); GO_0097192 (EC: IBA); GO_0097194 (EC: TAS, PMID:18309324); GO_2001235 (EC: IEA)
PMID:7789948; 8044845; 8087842; 8780721; 8962078; 8985253; 9044836; 9228018; 9261102; 9560245; 9695946; 9792675; 9847074; 10079193; 10329646; 10791974; 10980123; 11076957; 11156409; 11278287; 11313953; 11350957; 11399776; 11425872; 11823470; 11830582; 11832478; 11972030; 12011445; 12065594; 12107826; 12145703; 12193789; 12477715; 12477932; 12584573; 12598307; 12787561; 12837286; 12853948; 12920126; 14584591; 14623896; 14647455; 14701762; 14702039; 14713958; 14716300; 15073321; 15173176; 15262979; 15297885; 15489334; 15500642; 15511269; 15555560; 15590671; 15735701; 15817479; 15843892; 15882978; 16172118; 16193064; 16227610; 16344560; 16360037; 16387548; 16652156; 16701639; 16777994; 16822901; 16843824; 17079734; 17159900; 17195089; 17627033; 17637755; 17902043; 17945178; 18166155; 18238895; 18309324; 18375382; 18413747; 18418048; 18723680; 18840686; 19074885; 19269008; 19322201; 19347032; 19414860; 19453261; 19573080; 19593445; 19604093; 19715609; 19730412; 19738422; 19773279; 19935698; 20143425; 20158568; 20187765; 20208132; 20402676; 20453000; 20819778; 20855536; 20978129; 21051981; 21332795; 21415862; 21475302; 21726810; 21828056; 21900206; 21903589; 21906983; 21940110; 21988832; 22002103; 22077397; 22174370; 22201672; 22396545; 22486813; 22505724; 22531785; 22825847; 23042294; 23404198; 23469978; 23553630; 23568547; 24250222; 24321384
caspase 2, apoptosis-related cysteine peptidase
Ensembl:ENSG00000106144
HGNC:1503
HPRD:02800
MIM:600639
Vega:OTTHUMG00000023641
Other designations: caspase-2|neural precursor cell expressed developmentally down-regulated protein 2|protease ICH-1|protein phosphatase 1, regulatory subunit 57
CASP2
Bin Zhao, Yue Liu, Oliver He
CPP32
CPP32B
SCA-1
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP3
caspase 3, apoptosis-related cysteine peptidase
836
4q34
9606
4
GO_0001782 (EC: IEA); GO_0001836 (EC: IEA); GO_0004190 (EC: EXP); GO_0004197 (EC: IDA, PMID:19240112); GO_0004197 (EC: TAS); GO_0004861 (EC: IEA); GO_0005515 (EC: IPI, PMID:16501604); GO_0005634 (EC: IDA, PMID:17167422); GO_0005654 (EC: TAS); GO_0005829 (EC: IDA, PMID:17167422); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006309 (EC: TAS); GO_0006508 (EC: IDA, PMID:12888622); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0006974 (EC: IEA); GO_0007507 (EC: IEA); GO_0007605 (EC: IEA); GO_0008233 (EC: IDA, PMID:17167422); GO_0008625 (EC: IEA); GO_0008631 (EC: IEA); GO_0008635 (EC: TAS); GO_0009411 (EC: IEA); GO_0009611 (EC: IEA); GO_0022617 (EC: TAS); GO_0030182 (EC: IBA); GO_0030198 (EC: TAS); GO_0030216 (EC: IBA); GO_0030218 (EC: IDA, PMID:17167422); GO_0030218 (EC: TAS, PMID:18309324); GO_0030220 (EC: TAS, PMID:18309324); GO_0030889 (EC: IEA); GO_0034349 (EC: IEA); GO_0034612 (EC: TAS, PMID:10521396); GO_0035329 (EC: TAS); GO_0042981 (EC: TAS); GO_0043029 (EC: IEA); GO_0043065 (EC: TAS); GO_0043066 (EC: IGI, PMID:9353287); GO_0043281 (EC: TAS); GO_0043525 (EC: IEA); GO_0045165 (EC: IEA); GO_0045736 (EC: IEA); GO_0046007 (EC: IEA); GO_0048011 (EC: TAS); GO_0051402 (EC: IEA); GO_0097153 (EC: IMP, PMID:10921886); GO_0097190 (EC: TAS, PMID:10521396); GO_0097192 (EC: IEA); GO_0097193 (EC: TAS); GO_0097194 (EC: IDA, PMID:8689682); GO_0097194 (EC: IMP, PMID:11350920); GO_0097200 (EC: IMP, PMID:17559062)
PMID:1067155; 7596430; 7774019; 7983002; 8044845; 8605870; 8626669; 8673606; 8689682; 8696339; 8755496; 8780721; 8804412; 8812467; 8900201; 8943232; 8962078; 8976194; 9021152; 9045680; 9108473; 9115219; 9206994; 9208847; 9219695; 9230442; 9233763; 9235961; 9252332; 9267021; 9278461; 9298992; 9323209; 9326610; 9334214; 9334240; 9334338; 9337844; 9348292; 9351817; 9353287; 9361003; 9367996; 9368003; 9384571; 9395403; 9422780; 9452471; 9525868; 9535906; 9545236; 9548463; 9593687; 9618490; 9624143; 9632733; 9660939; 9671712; 9685336; 9694885; 9705209; 9708895; 9736630; 9751706; 9786869; 9799125; 9811849; 9840926; 9850056; 9857079; 9875225; 9878167; 9894612; 9933635; 9990034; 10022118; 10066732; 10069390; 10082566; 10103059; 10200531; 10205158; 10205159; 10319819; 10364179; 10409750; 10430052; 10432301; 10435619; 10438581; 10454555; 10469173; 10479680; 10490026; 10510468; 10521396; 10556977; 10564664; 10579725; 10602493; 10602513; 10608812; 10611247; 10629060; 10671544; 10672017; 10675528; 10704341; 10708425; 10712510; 10713703; 10734073; 10748026; 10770929; 10777594; 10791974; 10799874; 10821855; 10823823; 10862606; 10896157; 10899937; 10921886; 10926122; 10942389; 10998058; 11002417; 11016947; 11024045; 11042212; 11053413; 11058115; 11076937; 11084335; 11098060; 11106668; 11123279; 11141237; 11149901; 11162250; 11162351; 11170436; 11175261; 11177389; 11222676; 11230124; 11242052; 11248093; 11257230; 11257232; 11261798; 11274152; 11278283; 11278287; 11278424; 11278572; 11278782; 11278797; 11283607; 11313965; 11331419; 11345898; 11350920; 11356849; 11359776; 11387340; 11399776; 11420704; 11423904; 11425872; 11437602; 11438643; 11447297; 11462036; 11470874; 11478781; 11479289; 11500511; 11509621; 11514563; 11517310; 11526478; 11550094; 11551979; 11555640; 11602184; 11675509; 11689006; 11696595; 11741893; 11748221; 11752060; 11752215; 11787859; 11788610; 11795487; 11802788; 11815631; 11825902; 11830582; 11832478; 11840332; 11854437; 11859414; 11866986; 11875078; 11901153; 11904443; 11927604; 11948397; 11960384; 11972398; 11981455; 11988074; 11989976; 11992386; 12004072; 12019321; 12032677; 12036886; 12044963; 12055227; 12070005; 12070657; 12080079; 12095993; 12107159; 12112012; 12118383; 12124386; 12145703; 12149654; 12150947; 12151338; 12169388; 12181128; 12181742; 12186978; 12190962; 12207967; 12210761; 12228224; 12235123; 12297281; 12390838; 12393901; 12397210; 12401855; 12404116; 12425945; 12438416; 12444137; 12477932; 12483536; 12490308; 12511568; 12515825; 12566444; 12576296; 12576443; 12579342; 12581734; 12598529; 12605885; 12606589; 12611892; 12621124; 12624662; 12643601; 12657644; 12677451; 12686427; 12700630; 12700660; 12707329; 12750393; 12750404; 12760639; 12787561; 12788227; 12788938; 12792782; 12804035; 12809603; 12821118; 12824190; 12833566; 12837287; 12854132; 12867600; 12874324; 12888622; 12897143; 14555204; 14570914; 14572611; 14612448; 14623896; 14657946; 14674699; 14678329; 14684629; 14710359; 14764700; 14960581; 14970175; 14971566; 14976035; 14982947; 14991812; 14993250; 15014070; 15015772; 15033720; 15033815; 15041704; 15087450; 15098015; 15153940; 15156398; 15178331; 15179054; 15186778; 15187159; 15200957; 15204919; 15205454; 15220451; 15241180; 15246206; 15254227; 15258591; 15280469; 15345747; 15375594; 15473998; 15489334; 15505416; 15507451; 15542841; 15564512; 15569669; 15569672; 15569692; 15578977; 15599395; 15617521; 15637055; 15638357; 15650747; 15657349; 15657356; 15670787; 15705385; 15706351; 15716280; 15725353; 15735701; 15748158; 15748808; 15767427; 15803189; 15806167; 15843892; 15848173; 15869582; 15935070; 15996160; 16009347; 16080782; 16083554; 16111829; 16120388; 16121124; 16179347; 16203739; 16204230; 16213496; 16227597; 16242324; 16286477; 16300929; 16320828; 16330530; 16337360; 16338743; 16344560; 16382148; 16455648; 16463650; 16480911; 16498457; 16501604; 16505307; 16511342; 16516911; 16520893; 16526059; 16529748; 16530181; 16530191; 16543147; 16567804; 16651613; 16689860; 16716256; 16781734; 16787777; 16791842; 16802364; 16808908; 16835231; 16869888; 16882668; 16884727; 16894574; 16897667; 16931214; 16935258; 16948902; 16949642; 16955788; 16977583; 16979168; 16983089; 17008916; 17013756; 17013758; 17023557; 17038954; 17065568; 17069460; 17071630; 17080552; 17114647; 17118559; 17121821; 17123522; 17124493; 17130234; 17140287; 17141888; 17143787; 17167422; 17172814; 17198755; 17217622; 17219053; 17235653; 17245643; 17261582; 17272816; 17283187; 17291493; 17301822; 17321792; 17324936; 17337451; 17340613; 17364171; 17379327; 17412564; 17413988; 17430778; 17436592; 17437405; 17462862; 17488272; 17495975; 17498346; 17505517; 17525639; 17534194; 17544405; 17559062; 17597071; 17606719; 17606900; 17616526; 17645689; 17653867; 17689858; 17698513; 17721932; 17724022; 17805550; 17823127; 17880920; 17908973; 17928446; 17936584; 17950632; 17967742; 17978580; 17981569; 17983802; 17989718; 18000616; 18029348; 18047842; 18054197; 18055116; 18058802; 18060501; 18074388; 18083346; 18086147; 18088367; 18092356; 18155705; 18155731; 18164959; 18171980; 18209072; 18211414; 18227733; 18256758; 18256791; 18266005; 18296636; 18297401; 18298948; 18300076; 18309324; 18330265; 18379198; 18381704; 18384375; 18415681; 18415689; 18427836; 18439040; 18441516; 18450750; 18473402; 18476631; 18521960; 18551626; 18561948; 18577580; 18585351; 18586680; 18623086; 18652315; 18658137; 18669646; 18676680; 18708163; 18712678; 18723680; 18727869; 18754867; 18759060; 18763039; 18768468; 18814044; 18818379; 18820371; 18821563; 18829519; 18838202; 18844072; 18946722; 18986328; 19013323; 19035131; 19043361; 19046417; 19052714; 19058789; 19074885; 19132366; 19141860; 19157504; 19157506; 19159073; 19170196; 19178812; 19200347; 19204086; 19219602; 19223905; 19236754; 19240112; 19241192; 19244543; 19258326; 19266703; 19269008; 19270727; 19272183; 19275584; 19275586; 19275587; 19281794; 19283487; 19289465; 19299722; 19319745; 19322201; 19351510; 19355923; 19379562; 19404232; 19414860; 19453261; 19458171; 19513559; 19519609; 19531679; 19544333; 19549685; 19550122; 19553679; 19557639; 19559790; 19567200; 19570417; 19573080; 19585117; 19598027; 19604093; 19610261; 19625176; 19626422; 19636556; 19655253; 19655254; 19655415; 19665028; 19692168; 19692467; 19698783; 19698994; 19715609; 19723039; 19724860; 19724907; 19730442; 19738422; 19759058; 19770576; 19770581; 19773279; 19774677; 19784808; 19788069; 19788411; 19807657; 19812265; 19826114; 19838207; 19840460; 19854241; 19878567; 19895210; 19913121; 19925402; 19937139; 19942343; 19956888; 19996122; 19996272; 19996275; 19996278; 20001963; 20012528; 20025478; 20038816; 20041182; 20042134; 20045442; 20060927; 20063052; 20068062; 20072652; 20085765; 20087649; 20101263; 20103643; 20104682; 20142237; 20150439; 20180022; 20198319; 20227371; 20299368; 20307198; 20340172; 20346214; 20383567; 20402676; 20404718; 20423928; 20424172; 20450729; 20453000; 20492341; 20512574; 20530714; 20566630; 20580881; 20598358; 20619728; 20628086; 20628645; 20632819; 20644561; 20661084; 20665667; 20667824; 20683021; 20683843; 20702410; 20722551; 20723300; 20738749; 20801175; 20814064; 20839416; 20855536; 20856198; 20862799; 20919853; 20929126; 20947770; 20950443; 20959405; 20962079; 20966960; 20981869; 21029675; 21048031; 21081164; 21098975; 21099290; 21099299; 21123175; 21123558; 21139048; 21142842; 21148072; 21151026; 21160486; 21178828; 21203962; 21216952; 21223758; 21237154; 21248767; 21255440; 21270757; 21307660; 21317880; 21319273; 21382445; 21441410; 21479362; 21483469; 21483669; 21484410; 21504623; 21506333; 21548803; 21555338; 21561870; 21624464; 21644054; 21644232; 21667042; 21668377; 21671484; 21682651; 21700414; 21706480; 21724551; 21725926; 21729540; 21756903; 21775054; 21785112; 21802116; 21819468; 21827945; 21859712; 21869592; 21875325; 21880013; 21890473; 21914347; 21926353; 21944661; 21959934; 21963094; 21987091; 21988832; 22013052; 22072751; 22094081; 22121772; 22136337; 22147199; 22184067; 22191568; 22216281; 22238643; 22242595; 22298410; 22302483; 22309278; 22320973; 22429811; 22429842; 22482362; 22496955; 22504224; 22541080; 22552851; 22568453; 22607239; 22629415; 22678593; 22683311; 22764223; 22796265; 22815893; 22832123; 22837201; 22844442; 22872644; 22885173; 22912727; 22926545; 22931643; 22939953; 22944165; 22949938; 22951837; 22952982; 22964638; 23000965; 23054082; 23103707; 23122728; 23152053; 23156805; 23170075; 23170789; 23220614; 23221544; 23271051; 23271418; 23295106; 23326121; 23345589; 23384723; 23386603; 23416147; 23421973; 23519117; 23531593; 23545262; 23555267; 23568731; 23591201; 23599180; 23650375; 23658722; 23686572; 23703388; 23708668; 23724505; 23765963; 23775301; 23781587; 23791066; 23846227; 23867824; 23892923; 23894522; 23900644; 23907941; 23949910; 23979166; 24009453; 24129493; 24161344; 24553140
caspase 3, apoptosis-related cysteine peptidase
Ensembl:ENSG00000164305
HGNC:1504
HPRD:02799
MIM:600636
Vega:OTTHUMG00000133681
Other designations: CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
CASP3
Bin Zhao, Yue Liu, Oliver He
ICE(rel)II
ICEREL-II
ICH-2
Mih1/TX
TX
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP4
caspase 4, apoptosis-related cysteine peptidase
837
11q22.2-q22.3
9606
11
GO_0004197 (EC: IBA); GO_0005737 (EC: IBA); GO_0005739 (EC: IEA); GO_0005789 (EC: IEA); GO_0006508 (EC: TAS, PMID:7797510); GO_0006915 (EC: TAS, PMID:7743998); GO_0042981 (EC: IEA); GO_0050727 (EC: IBA); GO_0072557 (EC: IBA); GO_0072559 (EC: IBA); GO_0097169 (EC: IBA); GO_0097194 (EC: IBA)
PMID:1919001; 7743998; 7797510; 7797592; 8125298; 8962078; 9233763; 9250871; 9539746; 9694885; 9792675; 9875225; 10069390; 10329646; 10477277; 10872455; 11927604; 12096920; 12477932; 14702039; 15123740; 15146197; 15326478; 15489334; 15500642; 15975932; 16920334; 17353931; 17942194; 18029041; 18056395; 19269008; 19414860; 19573080; 19705160; 19773279; 20237496; 20402676; 20453000; 20514521; 20816908; 20855536; 21282934; 21317160; 21479362; 21781452; 21832049; 21984918; 21988832; 22246630; 22733992; 23661706; 23684308
caspase 4, apoptosis-related cysteine peptidase
Ensembl:ENSG00000196954
HGNC:1505
HPRD:04047
MIM:602664
Vega:OTTHUMG00000166078
Other designations: CASP-4|ICE(rel)-II|apoptotic cysteine protease Mih1/TX|caspase 4, apoptosis-related cysteine protease|caspase-4|protease ICH-2|protease TX
CASP4
Bin Zhao, Yue Liu, Oliver He
ICE(rel)III
ICEREL-III
ICH-3
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP5
caspase 5, apoptosis-related cysteine peptidase
838
11q22.2-q22.3
9606
11
GO_0004197 (EC: IBA); GO_0005737 (EC: IBA); GO_0006508 (EC: TAS, PMID:7797592); GO_0006915 (EC: TAS, PMID:7797592); GO_0008234 (EC: TAS, PMID:7797592); GO_0021762 (EC: IEP); GO_0042981 (EC: IEA); GO_0050727 (EC: IBA); GO_0071260 (EC: IEP, PMID:19593445); GO_0072557 (EC: IBA, Qualifier: NOT); GO_0072558 (EC: IDA, PMID:12191486); GO_0072559 (EC: IBA, Qualifier: NOT); GO_0097169 (EC: IBA, Qualifier: NOT); GO_0097194 (EC: IBA)
PMID:7797592; 8617266; 9250871; 9298992; 9894612; 10872455; 10986288; 11356849; 11535131; 12191486; 12477932; 12479849; 12853457; 12964016; 15886296; 16886895; 16893518; 17418785; 17676485; 18430458; 19074885; 19203830; 19269008; 19270026; 19414860; 19573080; 19593445; 19604093; 19773279; 20237496; 20379614; 20402676; 20434535; 20635389; 20855536; 21051981; 21191419; 21454616; 21668377; 21700414; 21969293; 22906436
caspase 5, apoptosis-related cysteine peptidase
Ensembl:ENSG00000137757
HGNC:1506
HPRD:04048
MIM:602665
Vega:OTTHUMG00000048073
Other designations: CASP-5|ICE(rel)-III|TY protease|caspase 5, apoptosis-related cysteine protease|caspase-5|protease ICH-3|protease TY
CASP5
Bin Zhao, Yue Liu, Oliver He
MCH2
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP6
caspase 6, apoptosis-related cysteine peptidase
839
4q25
9606
4
GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID:12888622); GO_0005654 (EC: TAS); GO_0005829 (EC: IDA, PMID:17167422); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID:12888622); GO_0006915 (EC: IBA); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0008234 (EC: TAS, PMID:7796396); GO_0030855 (EC: IEP); GO_0042802 (EC: IPI)
PMID:7796396; 7983002; 8710882; 8780721; 8812467; 8900201; 8962078; 8978814; 9219695; 9228018; 9298992; 9337844; 9463409; 9593687; 9857079; 9933635; 9990034; 10069390; 10103059; 10205159; 10409650; 10432301; 10438520; 10469173; 10481058; 10655504; 10734073; 10770929; 11016947; 11098060; 11246070; 11262188; 11331782; 11356849; 11387340; 11423904; 11438643; 11463840; 11514563; 11802788; 11832478; 11859414; 11901153; 11953316; 12052891; 12089322; 12145703; 12232792; 12477932; 12888622; 14713958; 15103018; 15200957; 15273717; 15280469; 15321985; 15356202; 15489334; 15500642; 15511269; 15654952; 15735701; 16123779; 16135563; 16169070; 16341674; 16518869; 16948818; 16977583; 17167422; 17337451; 17392160; 18029348; 18155731; 18408014; 18497562; 18723680; 18762957; 18820706; 18946722; 19022247; 19052714; 19219602; 19269008; 19414860; 19573080; 19694615; 19773279; 19897582; 19915487; 20097875; 20332099; 20402676; 20427671; 20437871; 20606168; 20661084; 20682790; 20702410; 20801175; 20855536; 20890311; 21098228; 21111746; 21139048; 21317160; 21621544; 21900206; 21906983; 21918813; 21936563; 21963094; 21988832; 22094081; 22433863; 22505724; 22683611; 22858542; 22891250; 23402898
caspase 6, apoptosis-related cysteine peptidase
Ensembl:ENSG00000138794
HGNC:1507
HPRD:03321
MIM:601532
Vega:OTTHUMG00000131914
Other designations: apoptotic protease MCH-2|caspase 6, apoptosis-related cysteine protease|caspase-6
CASP6
Bin Zhao, Yue Liu, Oliver He
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP7
caspase 7, apoptosis-related cysteine peptidase
840
RP11-211N11.6
10q25
9606
10
GO_0001836 (EC: IEA); GO_0004190 (EC: IEA); GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID:11084335); GO_0005634 (EC: IDA, PMID:17167422); GO_0005654 (EC: TAS); GO_0005737 (EC: TAS, PMID:8576161); GO_0005829 (EC: IDA, PMID:17167422); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID:12888622); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0007507 (EC: IEA); GO_0007568 (EC: IEA); GO_0008234 (EC: TAS, PMID:8567622); GO_0008635 (EC: TAS); GO_0009411 (EC: IEA); GO_0043525 (EC: IEA); GO_0097153 (EC: IEA); GO_0097193 (EC: TAS); GO_0097194 (EC: IBA)
PMID:1056466; 7983002; 8125298; 8521391; 8567622; 8576161; 8631895; 8755496; 8780721; 8812467; 8889548; 8962078; 9070923; 9219695; 9228018; 9230442; 9298992; 9323209; 9325343; 9337844; 9384571; 9525868; 9535906; 9593687; 9607320; 9671712; 9850056; 9875225; 9894612; 9922454; 9990034; 10069390; 10082581; 10103059; 10200531; 10318789; 10469173; 10564664; 10675528; 10731697; 10791974; 10862606; 10998058; 11016947; 11024045; 11058599; 11084335; 11170436; 11257230; 11257231; 11257232; 11278572; 11356849; 11359776; 11387340; 11399776; 11420704; 11423904; 11425872; 11448953; 11514563; 11535131; 11555640; 11752425; 11755217; 11802788; 11815631; 11829465; 11832478; 11859414; 11875078; 11904443; 11943137; 12107159; 12145703; 12181742; 12477932; 12586738; 12665508; 12804035; 12824163; 12888622; 12951057; 12970753; 14512414; 14583630; 14584591; 14623896; 14713958; 15033720; 15200957; 15254227; 15489334; 15500642; 15507451; 15511269; 15580265; 15650747; 15735701; 16123041; 16213496; 16339151; 16344560; 16385451; 16498457; 16918502; 17023557; 17094969; 17167422; 17283187; 17337451; 17504820; 17532763; 17697120; 17880920; 17978580; 18072206; 18086147; 18459962; 18521960; 18596415; 18708163; 18723680; 18785314; 19022247; 19052714; 19058873; 19141860; 19219602; 19241192; 19258326; 19269008; 19323650; 19414860; 19531679; 19573080; 19581639; 19604093; 19605487; 19617626; 19655253; 19655254; 19692467; 19698783; 19738422; 19759058; 19770576; 19773279; 19782763; 19826114; 19913121; 19996278; 20159985; 20379614; 20402676; 20404718; 20453000; 20468060; 20566630; 20567846; 20628086; 20661084; 20800603; 20819778; 20855536; 20950443; 20959405; 21044950; 21142842; 21157428; 21484410; 21555521; 21936563; 22184066; 22441531; 22451931; 22548721; 22561518; 22584050; 22863883; 22986525; 23000965; 23190606; 23383273; 23650375; 23765963; 23979166
caspase 7, apoptosis-related cysteine peptidase
Ensembl:ENSG00000165806
HGNC:1508
HPRD:03457
MIM:601761
Vega:OTTHUMG00000019076
Other designations: ICE-like apoptotic protease 3|apoptotic protease MCH-3|caspase 7, apoptosis-related cysteine protease|caspase-7
CASP7
Bin Zhao, Yue Liu, Oliver He
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP8
caspase 8, apoptosis-related cysteine peptidase
841
2q33-q34
9606
2
GO_0001525 (EC: IEA); GO_0001841 (EC: IEA); GO_0002020 (EC: IPI); GO_0002224 (EC: TAS); GO_0002756 (EC: TAS); GO_0004197 (EC: IDA, PMID:19240112); GO_0004197 (EC: TAS); GO_0005164 (EC: IEA); GO_0005515 (EC: IPI, PMID:10442631); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005741 (EC: TAS); GO_0005815 (EC: IDA); GO_0005829 (EC: IDA, PMID:17167422); GO_0005829 (EC: TAS); GO_0005856 (EC: TAS, PMID:10891503); GO_0006508 (EC: IDA, PMID:12888622); GO_0006915 (EC: IGI, PMID:17599062); GO_0006915 (EC: IMP); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0006921 (EC: TAS); GO_0007507 (EC: IEA); GO_0008233 (EC: IMP, PMID:17047155); GO_0008234 (EC: TAS, PMID:8681376); GO_0008625 (EC: IBA); GO_0009409 (EC: IEA); GO_0016032 (EC: IEA); GO_0030101 (EC: TAS, PMID:18309324); GO_0030225 (EC: TAS, PMID:18309324); GO_0030690 (EC: IEA); GO_0031264 (EC: IDA, PMID:11101870); GO_0031265 (EC: IDA, PMID:11717445); GO_0031625 (EC: IPI, PMID:15069192); GO_0032025 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034612 (EC: IMP, PMID:10521396); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0035877 (EC: IPI, PMID:11717445); GO_0042110 (EC: TAS, PMID:18309324); GO_0042113 (EC: TAS, PMID:18309324); GO_0043005 (EC: IEA); GO_0043123 (EC: IEP, PMID:12761501); GO_0043123 (EC: IMP, PMID:12884866); GO_0043124 (EC: IMP, PMID:17047155); GO_0044297 (EC: IEA); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045471 (EC: IEA); GO_0045651 (EC: IMP, PMID:17047155); GO_0045862 (EC: IDA, PMID:18387192); GO_0046677 (EC: IEA); GO_0051291 (EC: IEA); GO_0051603 (EC: IMP, PMID:10521396); GO_0060715 (EC: TAS, PMID:18309324); GO_0070243 (EC: IEA); GO_0070423 (EC: TAS); GO_0071260 (EC: IEP, PMID:19593445); GO_0071407 (EC: IEA); GO_0097153 (EC: IMP); GO_0097190 (EC: IMP, PMID:11101870); GO_0097190 (EC: TAS); GO_0097191 (EC: IDA); GO_0097193 (EC: TAS); GO_0097194 (EC: IMP); GO_0097199 (EC: IMP, PMID:11717445); GO_0097202 (EC: IDA, PMID:18387192); GO_0097284 (EC: IEA); GO_0097342 (EC: IDA); GO_1900740 (EC: TAS); GO_2001238 (EC: IEA); GO_2001239 (EC: TAS)
PMID:170210; 3031469; 7983002; 8521391; 8681376; 8681377; 8755496; 8962078; 9006941; 9027312; 9184224; 9208847; 9219695; 9228018; 9271594; 9289491; 9325248; 9326610; 9334338; 9337844; 9380701; 9535906; 9539746; 9560245; 9575181; 9624166; 9632733; 9721089; 9727491; 9727492; 9763668; 9774341; 9792675; 9804161; 9875225; 9878167; 9931493; 9971775; 9990034; 10069390; 10235259; 10329646; 10432301; 10435619; 10438581; 10442631; 10469173; 10493725; 10508784; 10521396; 10616217; 10708425; 10716992; 10734073; 10860845; 10891503; 10894160; 10911620; 10926122; 10964557; 11000244; 11002417; 11016947; 11048727; 11085743; 11098060; 11101867; 11101870; 11102441; 11161814; 11177389; 11181075; 11260720; 11264300; 11340079; 11387340; 11395500; 11406564; 11420686; 11423904; 11431480; 11437602; 11479289; 11514563; 11555640; 11583996; 11683038; 11684016; 11717445; 11733517; 11734564; 11735112; 11741396; 11741985; 11751056; 11751897; 11752160; 11772515; 11788820; 11832478; 11865194; 11877293; 11917123; 11933563; 11940602; 11965497; 11992615; 12010809; 12021264; 12037669; 12041673; 12052891; 12065591; 12095993; 12096338; 12097160; 12107159; 12107169; 12122017; 12131184; 12170765; 12189238; 12191471; 12196516; 12198154; 12215447; 12218097; 12220669; 12232792; 12353035; 12393901; 12404116; 12438416; 12477932; 12496481; 12496482; 12507932; 12527898; 12598529; 12620239; 12646168; 12668660; 12692130; 12700635; 12700660; 12702723; 12707329; 12721308; 12738800; 12748179; 12750393; 12750404; 12753742; 12754217; 12761501; 12765336; 12804595; 12841868; 12884866; 12887920; 12888622; 12911633; 12912912; 12960156; 13679856; 14522966; 14560027; 14584591; 14625033; 14644092; 14644197; 14684825; 14688019; 14701762; 14713958; 14759258; 14970175; 14982875; 14982947; 14991747; 14993214; 15015772; 15024054; 15034549; 15067048; 15069192; 15111130; 15142380; 15159409; 15205454; 15210716; 15254227; 15262979; 15280356; 15289853; 15369772; 15383280; 15388581; 15389560; 15390286; 15473998; 15476874; 15489334; 15492869; 15507451; 15507484; 15509781; 15531912; 15578977; 15592455; 15592525; 15601643; 15611097; 15637055; 15640164; 15645452; 15650242; 15659383; 15701651; 15717329; 15735701; 15735742; 15746428; 15760909; 15782135; 15815621; 15849201; 15906362; 15956881; 15976052; 16036110; 16135563; 16169070; 16179347; 16179941; 16183855; 16186808; 16193064; 16225956; 16227629; 16242324; 16251207; 16344560; 16374545; 16397500; 16436380; 16446372; 16478725; 16497673; 16528386; 16538383; 16541419; 16556893; 16607283; 16619028; 16633737; 16636047; 16722146; 16733806; 16762833; 16886176; 16920630; 16936772; 16938569; 16951203; 17018785; 17030903; 17047155; 17064406; 17071630; 17159907; 17167422; 17170703; 17182797; 17224200; 17272309; 17283187; 17290218; 17293864; 17314102; 17337451; 17378240; 17436592; 17442709; 17450141; 17488272; 17525260; 17532763; 17534194; 17545522; 17572490; 17585337; 17599062; 17616526; 17623017; 17626072; 17627287; 17653867; 17666167; 17684142; 17726263; 17891485; 17911615; 17932347; 17940865; 18029348; 18045865; 18054197; 18076022; 18086677; 18089778; 18089800; 18097748; 18158779; 18161513; 18216014; 18245485; 18305469; 18309324; 18324486; 18328427; 18343995; 18362937; 18381704; 18387192; 18398042; 18431743; 18455983; 18458084; 18473402; 18483392; 18485876; 18516683; 18563783; 18570872; 18596409; 18603835; 18617900; 18625728; 18632964; 18675369; 18676680; 18676836; 18684943; 18691973; 18716417; 18725521; 18728974; 18776134; 18796435; 18823309; 18823701; 18840411; 18974049; 19001123; 19013323; 19048023; 19048627; 19060883; 19074885; 19094228; 19111387; 19112091; 19115040; 19122169; 19124506; 19125371; 19141860; 19152111; 19160091; 19166881; 19170196; 19176810; 19203830; 19214542; 19214744; 19219602; 19239323; 19240112; 19258216; 19260109; 19269008; 19275584; 19275586; 19276244; 19289465; 19318553; 19343040; 19345995; 19372376; 19373245; 19412632; 19414860; 19427028; 19432816; 19453261; 19470771; 19492233; 19493480; 19521670; 19528225; 19531679; 19542541; 19543235; 19550122; 19573080; 19593445; 19597472; 19617217; 19625176; 19629679; 19644511; 19665028; 19684859; 19692168; 19692467; 19698994; 19710364; 19738422; 19770581; 19773279; 19773432; 19778795; 19795398; 19801665; 19807657; 19812265; 19826114; 19843670; 19852930; 19854135; 19902255; 19913121; 19923319; 19954364; 19996275; 20005201; 20012528; 20013803; 20033750; 20033885; 20044137; 20080300; 20085538; 20086182; 20087649; 20132554; 20143425; 20145138; 20150972; 20176653; 20198319; 20237344; 20301425; 20308068; 20353946; 20356928; 20363033; 20379197; 20398055; 20402676; 20403046; 20404718; 20443055; 20448643; 20453000; 20471133; 20502973; 20554749; 20564345; 20565257; 20572163; 20605201; 20606168; 20613771; 20616437; 20628086; 20644561; 20652397; 20661084; 20671745; 20677014; 20702410; 20724831; 20799830; 20800603; 20802294; 20804486; 20808443; 20811726; 20817393; 20819778; 20825417; 20829884; 20855536; 20870287; 20877624; 20937773; 20951133; 20959405; 20972266; 20978129; 20978178; 21048031; 21072056; 21104989; 21107701; 21135236; 21139048; 21153367; 21157428; 21166494; 21178828; 21183680; 21183955; 21248767; 21282461; 21328377; 21380726; 21396853; 21419663; 21426305; 21436691; 21444671; 21454681; 21458669; 21461653; 21483669; 21487429; 21524651; 21525013; 21538054; 21548803; 21554547; 21569377; 21576355; 21620750; 21628531; 21633787; 21667042; 21669575; 21697465; 21704196; 21714991; 21724551; 21737329; 21751259; 21785112; 21785459; 21801448; 21803845; 21816816; 21819468; 21822306; 21865223; 21868312; 21900206; 21906983; 21979465; 21983787; 21988832; 22010212; 22027693; 22037414; 22056502; 22094081; 22120515; 22160860; 22179575; 22211869; 22253841; 22266862; 22267217; 22274400; 22297296; 22322857; 22339913; 22357491; 22383778; 22408249; 22421964; 22508042; 22513478; 22528489; 22585859; 22588838; 22632162; 22644571; 22659694; 22672670; 22683265; 22683266; 22691345; 22801217; 22806078; 22815944; 22820578; 22843554; 22860893; 22864571; 22922291; 22949938; 22971934; 23071110; 23081800; 23096115; 23142077; 23185580; 23230268; 23244104; 23255602; 23289213; 23306557; 23313206; 23418437; 23434145; 23618862; 23659359; 23751956; 23770605; 23844036; 23921907; 23972990; 23982205; 24021263; 24121507; 24391214
caspase 8, apoptosis-related cysteine peptidase
Ensembl:ENSG00000064012
HGNC:1509
HPRD:03459
MIM:601763
Vega:OTTHUMG00000132821
Other designations: FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cysteine protease|caspase-8
CASP8
Bin Zhao, Yue Liu, Oliver He
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP9
caspase 9, apoptosis-related cysteine peptidase
842
RP11-265F14.3
1p36.21
9606
1
GO_0004197 (EC: IBA); GO_0005515 (EC: IPI, PMID:10206961); GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0005829 (EC: IDA, PMID:17167422); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS, PMID:8663294); GO_0006974 (EC: IDA, PMID:15657060); GO_0007173 (EC: TAS); GO_0007568 (EC: IEA); GO_0008047 (EC: TAS, PMID:9390557); GO_0008233 (EC: IDA); GO_0008543 (EC: TAS); GO_0008630 (EC: IMP, PMID:15657060); GO_0008635 (EC: TAS); GO_0017124 (EC: IDA, PMID:15657060); GO_0019901 (EC: IDA, PMID:15657060); GO_0030220 (EC: TAS, PMID:18309324); GO_0032025 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0034349 (EC: IEA); GO_0034644 (EC: IDA, PMID:15657060); GO_0038095 (EC: TAS); GO_0042770 (EC: IDA, PMID:15657060); GO_0042981 (EC: TAS); GO_0043065 (EC: TAS); GO_0043293 (EC: IDA); GO_0043525 (EC: IEA); GO_0045087 (EC: TAS); GO_0046677 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0071549 (EC: IEA); GO_0097193 (EC: TAS); GO_2001020 (EC: IMP, PMID:15657060)
PMID:1067155; 7983002; 8663294; 8900201; 8962078; 9323209; 9337844; 9390557; 9488720; 9539746; 9545235; 9651578; 9671712; 9812896; 9837928; 9878060; 9890966; 9922454; 9990849; 10070954; 10085063; 10187815; 10206961; 10329646; 10376594; 10384055; 10438581; 10469173; 10671558; 10708425; 11024045; 11069302; 11076957; 11084335; 11113115; 11230124; 11242052; 11248093; 11350957; 11387340; 11390657; 11393657; 11408476; 11423904; 11462036; 11514563; 11734640; 11801602; 11801603; 11803376; 11832478; 11870543; 11905052; 11919192; 11927604; 11948397; 12021264; 12055227; 12095993; 12096338; 12145703; 12147322; 12372609; 12393263; 12393884; 12404116; 12477932; 12566444; 12586738; 12620238; 12620239; 12637514; 12732844; 12749848; 12782307; 12792650; 12804035; 12914932; 12954616; 14512414; 14523016; 14566819; 14634335; 14684629; 14701803; 14747474; 14982875; 14991812; 14993223; 15200957; 15214043; 15220451; 15254227; 15262985; 15273730; 15280366; 15300255; 15473998; 15485395; 15485396; 15489334; 15500642; 15507451; 15578977; 15629764; 15657060; 15657349; 15674327; 15703181; 15725353; 15735701; 15749826; 15767427; 15811855; 15829969; 15935070; 16038259; 16120388; 16181301; 16242324; 16260615; 16287866; 16300929; 16322207; 16337360; 16339151; 16344560; 16480911; 16497673; 16505307; 16505493; 16511342; 16520893; 16687442; 16689829; 16701639; 16710414; 16716256; 16780893; 16895904; 16936772; 16979168; 17030903; 17071630; 17079734; 17140287; 17167422; 17179183; 17207965; 17285546; 17291493; 17299206; 17379327; 17409234; 17437405; 17466630; 17534194; 17626072; 17653867; 17893147; 17899380; 17967742; 18022362; 18054197; 18083711; 18086147; 18202770; 18297401; 18309324; 18381704; 18415681; 18632964; 18676680; 18723680; 18813792; 18814044; 18840411; 19013323; 19016842; 19052714; 19058789; 19074885; 19081073; 19141860; 19153467; 19159073; 19170196; 19183163; 19219602; 19238172; 19269008; 19275583; 19275584; 19275586; 19275587; 19359048; 19412632; 19414860; 19458171; 19465923; 19493480; 19550122; 19573080; 19625176; 19626422; 19655415; 19674438; 19692168; 19692467; 19698783; 19724860; 19741144; 19758996; 19770581; 19773279; 19789190; 19807657; 19826114; 19895210; 19906200; 19913121; 20012528; 20013803; 20022954; 20042134; 20060927; 20071584; 20227371; 20227384; 20340172; 20357690; 20379614; 20402676; 20404718; 20453000; 20490276; 20628086; 20644561; 20650551; 20661084; 20667824; 20800603; 20804486; 20855536; 20887385; 20959405; 20978129; 21045158; 21048031; 21091209; 21117896; 21142842; 21178828; 21266831; 21282934; 21284734; 21297999; 21382445; 21396853; 21461653; 21483669; 21538054; 21555338; 21565459; 21612408; 21622622; 21644232; 21659556; 21724551; 21757755; 21785112; 21827945; 21868008; 21869827; 21944661; 21957492; 21988832; 22086301; 22120515; 22191568; 22219640; 22306364; 22339913; 22552851; 22573662; 22616010; 22629415; 22679284; 22683311; 22926545; 22944165; 22974165; 22981751; 23038270; 23303631; 23383273; 23396972; 23424205; 23430060; 23443079; 23539542; 23566959; 23572523; 23615977; 23637769; 23645041; 23652278; 23678002; 23725396; 23867824; 24121507; 24161344; 24346702
caspase 9, apoptosis-related cysteine peptidase
Ensembl:ENSG00000132906
HGNC:1511
HPRD:03756
MIM:602234
Vega:OTTHUMG00000002256
Other designations: ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56
CASP9
Bin Zhao, Yue Liu, Oliver He
ALPS2
FLICE2
MCH4
WEB: http://www.ncbi.nlm.nih.gov/gene
CASP10
caspase 10, apoptosis-related cysteine peptidase
843
2q33-q34
9606
2
GO_0004197 (EC: TAS, PMID:10412980); GO_0005515 (EC: IPI, PMID:12884866); GO_0005737 (EC: IBA); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006915 (EC: IBA); GO_0006915 (EC: TAS); GO_0031265 (EC: IDA, PMID:11717445); GO_0031625 (EC: IPI, PMID:15069192); GO_0035877 (EC: IPI, PMID:11717445); GO_0042981 (EC: IEA); GO_0043123 (EC: IMP, PMID:12884866); GO_0043123 (EC: RCA, PMID:19641626); GO_0045087 (EC: TAS); GO_0097190 (EC: TAS); GO_0097199 (EC: IMP, PMID:11717445); GO_0097342 (EC: IDA)
PMID:170210; 1171445; 3031469; 8125298; 8521391; 8755496; 8962078; 9045686; 9153302; 9208847; 9228018; 9289491; 9325248; 9337844; 9792675; 10187817; 10412980; 10432301; 10716992; 10734073; 11002417; 11048727; 11098060; 11161814; 11395500; 11583996; 11717445; 11832478; 11973654; 12010812; 12037669; 12198154; 12388546; 12477932; 12527898; 12884866; 12887920; 14687710; 14688482; 14759258; 14761933; 15069192; 15280356; 15452117; 15500642; 15659383; 15735701; 15767684; 15772077; 16186808; 16251207; 16344560; 16446975; 16767158; 17071630; 17085968; 17159907; 17450141; 17479112; 17534194; 17623017; 17822854; 17999750; 18381704; 18563783; 18676680; 18716417; 18823309; 19074885; 19141860; 19166881; 19170196; 19219602; 19269008; 19380486; 19414860; 19423537; 19550122; 19604093; 19625176; 19641626; 19692168; 19773279; 19784808; 19826114; 19861680; 19900088; 19902255; 20025484; 20301287; 20402676; 20453000; 20467438; 20644561; 20661084; 20800603; 20802294; 20829884; 20855536; 20959405; 20978178; 21048031; 21139048; 21368896; 21454616; 21559821; 21911414; 21988832; 22683265; 22782902; 22843554; 22864571; 23212337; 23303631; 23541952; 23770605; 23921907
caspase 10, apoptosis-related cysteine peptidase
Ensembl:ENSG00000003400
HGNC:1500
HPRD:03458
MIM:601762
Vega:OTTHUMG00000132818
Other designations: CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2
CASP10
Bin Zhao, Yue Liu, Oliver He
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
WEB: http://www.ncbi.nlm.nih.gov/gene
CASR
calcium-sensing receptor
846
3q13
9606
3
Official from a nomenclature committee
GO_0001503 (EC: TAS, PMID: 7874174); GO_0004435 (EC: TAS, PMID: 7874174); GO_0004930 (EC: IEA); GO_0005513 (EC: TAS, PMID: 7759551); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 7759551); GO_0006874 (EC: TAS, PMID: 7874174); GO_0007186 (EC: TAS, PMID: 7759551); GO_0007635 (EC: TAS, PMID: 7759551); GO_0008152 (EC: TAS, PMID: 7874174); GO_0009653 (EC: TAS, PMID: 7916660); GO_0070509 (EC: IDA)
PMID: 7673400; 7677761; 7726161; 7759551; 7874174; 7916660; 8597637; 8613532; 8675635; 8702647; 8733126; 8756555; 9168937; 9217223; 9298824; 9677383; 9694886; 9722601; 9852126; 9920108; 9920407; 10405337; 10487661; 11013439; 11095989; 11108243; 11161843; 11248745; 11390379; 11390380; 11589681; 11668634; 11762699; 11863123; 11889154; 11889203; 11907035; 11979955; 11984699; 12018449; 12036954; 12040821; 12050233; 12052452; 12095982; 12150336; 12239240; 12241879; 12356761; 12399473; 12409307; 12459170; 12469911; 12477932; 12517779; 12544508; 12574201; 12605346; 12656660; 12700051; 12773131; 12783889; 12890593; 12899245; 12914574; 14508624; 14660633; 14713274; 14729680; 14976203; 14985373; 15201280; 15219850; 15472173; 15489334; 15501733; 15531522; 15551332; 15572418; 15579475; 15591042; 15598778; 15613438; 15637145; 15657061; 15684428; 15718278; 15781005; 15805541; 15837785; 15864123; 15879434; 15888439; 15960151; 16109841; 16117875; 16147994; 16218047; 16278666; 16472767; 16497624; 16509534; 16513638; 16596260; 16598859; 16616098; 16622736; 16642557; 16735501; 16738533; 16740430; 16754659; 16854379; 16938272; 17018660; 17046587; 17054460; 17062884; 17097611; 17110864; 17122384; 17124506; 17132283; 17138967; 17284438; 17309124; 17310098; 17320849; 17331389; 17332735; 17372216; 17374704; 17374709; 17426287; 17463182; 17473068; 17478419; 17482347; 17513419; 17537980; 17555508; 17591780; 17623778; 17698911; 17853337; 17932932; 17962359; 17974568; 17979873; 18065418; 18240029; 18296474; 18322048; 18328986; 18348986; 18393231; 18410554; 18443236; 18497443; 18525093; 18577758; 18621740; 18622738; 18676680; 18680227; 18703641; 18712808; 18751724; 18756473; 18796518; 18843020; 18852253; 18938753; 18980667; 19011996; 19035514; 19038444; 19058262; 19066294; 19073830; 19088423; 19133942; 19151705; 19157541; 19170196; 19179454; 19237714; 19257819; 19285978; 19328421; 19350667; 19389809; 19397786; 19423559; 19432691; 19453261; 19471101; 19474519; 19580466; 19621386; 19625176; 19640368; 19690432; 19692168; 19695239; 19706842; 19716891; 19789209; 19839774; 19887834; 19912241; 19913121; 19915295; 20034274; 20067903; 20130845; 20164288; 20237496; 20361938; 20364112; 20421307; 20424473; 20457124; 20558521; 20558539; 20595056; 20602573; 20628086; 20631026; 20634891; 20648625; 20654748; 20661308; 20668040; 20697181; 20705733; 20798521; 20826781; 20846291; 21048031; 21082232; 21084311; 21130730; 21183554; 21187282; 21209619; 21240254; 21317879; 21340433; 21369680; 21393549; 21414629; 21441391; 21532883; 21566074; 21645025; 21667241; 21843504; 21965686; 21966463; 22010828; 22024717; 22094462; 22107799; 22144504; 22158862; 22187299; 22192860; 22210744; 22278364; 22315359; 22403735; 22422767; 22424352; 22449852; 22577108; 22730443; 22789683; 22798347; 23009664; 23103379; 23108190; 23125333; 23169696; 23228129; 23247143; 23269116; 23271661; 23287098; 23300272; 23334987; 23372019; 23533647; 23552627; 23555732; 23569134; 23639611; 23674327; 23756480; 23764372; 23817301; 23856265; 23860708; 23864702; 23913941; 23917029; 23946278; 24068962; 24120622; 24238055; 24336654; 24455835
calcium-sensing receptor
Ensembl:ENSG00000036828
HGNC:1514
HPRD:03122
MIM:601199
Vega:OTTHUMG00000159491
Other designations: extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor 1
CASR
Bin Zhao, Yue Liu, Oliver He
CCNG
WEB: http://www.ncbi.nlm.nih.gov/gene
CCNG1
cyclin G1
900
5q32-q34
9606
5
Official from a nomenclature committee
GO_0000079 (EC: TAS, PMID: 8626390); GO_0005515 (EC: IPI); GO_0005634 (EC: IEA); GO_0006949 (EC: IEA); GO_0007067 (EC: IEA); GO_0007095 (EC: IEA); GO_0007420 (EC: IEA); GO_0010243 (EC: IEA); GO_0016049 (EC: IEA); GO_0019904 (EC: IEA); GO_0030425 (EC: IEA); GO_0043025 (EC: IEA); GO_0043066 (EC: IEA); GO_0048471 (EC: IEA)
PMID: 8626390; 8806701; 8887688; 8954786; 9013862; 10194136; 10196184; 11956189; 12214116; 12477932; 12556559; 12634633; 12642871; 12684677; 15077171; 15489334; 16322753; 17616664; 17868090; 18408012; 18632610; 18981217; 19584283; 19698214; 19738611; 21688120; 21832049; 21988832; 22105316; 22271581; 22649121; 22835824; 23589924
cyclin G1
Ensembl:ENSG00000113328
HGNC:1592
HPRD:03345
MIM:601578
Vega:OTTHUMG00000130380
Other designations: cyclin-G|cyclin-G1
CCNG1
Bin Zhao, Yue Liu, Oliver He
CDW44
CSPG8
ECMR-III
HCELL
HUTCH-I
IN
LHR
MC56
MDU2
MDU3
MIC4
Pgp1
WEB: http://www.ncbi.nlm.nih.gov/gene
CD44
CD44 molecule (Indian blood group)
960
AL133330.1
11p13
9606
11
Official from a nomenclature committee
GO_0001658 (EC: IEA); GO_0002246 (EC: IEA); GO_0004415 (EC: IDA, PMID: 17170110); GO_0004888 (EC: IDA, Qualifier: contributes_to, PMID: 17045821); GO_0005515 (EC: IPI, PMID: 11207560); GO_0005518 (EC: NAS, PMID: 2471973); GO_0005540 (EC: IDA, PMID: 17170110); GO_0005540 (EC: NAS, PMID: 1991450); GO_0005737 (EC: IDA); GO_0005794 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: NAS, PMID: 1991450); GO_0005975 (EC: TAS); GO_0007160 (EC: NAS, PMID: 1922057); GO_0007596 (EC: TAS); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA, PMID: 16809613); GO_0010628 (EC: IEA); GO_0016055 (EC: IEA); GO_0016323 (EC: IEA); GO_0016337 (EC: NAS, PMID: 1922057); GO_0019221 (EC: TAS); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030203 (EC: TAS); GO_0030212 (EC: TAS); GO_0030214 (EC: IDA, PMID: 17170110); GO_0030214 (EC: TAS); GO_0033138 (EC: IDA, PMID: 17045821); GO_0034116 (EC: IMP, PMID: 15100360); GO_0043066 (EC: IMP, PMID: 19047049); GO_0043154 (EC: IMP, PMID: 19047049); GO_0043518 (EC: IDA, PMID: 17045821); GO_0044281 (EC: TAS); GO_0044344 (EC: IDA, PMID: 19577615); GO_0050731 (EC: IDA, PMID: 17045821); GO_0050900 (EC: TAS); GO_0051216 (EC: IEP, PMID: 11944887); GO_0060333 (EC: TAS); GO_0060442 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19199708); GO_0070374 (EC: IDA, PMID: 17045821); GO_0070487 (EC: IMP, PMID: 15100360); GO_1900625 (EC: IMP); GO_1902166 (EC: IDA, PMID: 17045821)
PMID: 1281868; 1465456; 1496383; 1537855; 1694723; 1717145; 1730778; 1734871; 1840487; 1922057; 1991450; 2007624; 2056274; 2454887; 2466575; 2466576; 2471973; 2474557; 7499241; 7505012; 7508842; 7516819; 7529574; 7532176; 7539755; 7542116; 7557500; 7591309; 7699015; 7821789; 7908632; 8148709; 8343954; 8352881; 8576267; 8599448; 8636151; 8640758; 8649806; 8858161; 8871928; 8986622; 9058761; 9334256; 9472040; 9519902; 9573028; 9580567; 9794764; 10636882; 10652271; 10657301; 10737800; 10933060; 10950950; 11084024; 11095749; 11129651; 11207560; 11381077; 11402070; 11463356; 11466334; 11606575; 11716065; 11727257; 11740562; 11759056; 11792412; 11825873; 11825898; 11839564; 11840273; 11935029; 11944887; 12032545; 12090473; 12093135; 12127836; 12145196; 12145287; 12168806; 12183053; 12198147; 12223485; 12226094; 12235127; 12297287; 12356905; 12370738; 12371152; 12377945; 12392323; 12393872; 12407110; 12411303; 12421945; 12439723; 12444143; 12452061; 12477932; 12479099; 12485845; 12506143; 12508241; 12511569; 12511867; 12574156; 12629514; 12635659; 12650924; 12702150; 12711360; 12714503; 12727228; 12730955; 12748184; 12767055; 12779084; 12801931; 12820426; 12826680; 12842543; 12883358; 12893366; 12901833; 12908752; 12909589; 12911725; 12928429; 12939665; 12949055; 14504094; 14525786; 14534711; 14534719; 14614016; 14623895; 14644158; 14669354; 14702039; 14981907; 14992719; 15009704; 15013310; 15017146; 15023889; 15040016; 15048167; 15051494; 15060082; 15070674; 15100360; 15123640; 15239258; 15292257; 15313120; 15361838; 15452148; 15489334; 15509527; 15516973; 15531362; 15558018; 15578568; 15638368; 15638386; 15641486; 15645378; 15652352; 15655247; 15688033; 15728517; 15736104; 15783086; 15809746; 15816636; 15851553; 15867228; 15923644; 15943035; 15962382; 15990174; 16002044; 16085055; 16166750; 16177123; 16208414; 16219515; 16229685; 16234326; 16248506; 16311123; 16325770; 16335952; 16352650; 16354706; 16390331; 16407205; 16415175; 16419149; 16478744; 16494036; 16504370; 16530165; 16533775; 16554035; 16565089; 16565092; 16620830; 16636662; 16652145; 16702221; 16713680; 16809345; 16809613; 16848180; 16868940; 16969488; 16998483; 16998484; 17045821; 17081983; 17085435; 17092940; 17135256; 17136494; 17170110; 17237445; 17265493; 17324121; 17332338; 17343740; 17381240; 17383158; 17392272; 17464868; 17479111; 17482182; 17516109; 17540049; 17579117; 17581168; 17589956; 17599831; 17611661; 17611662; 17627000; 17638891; 17657222; 17679465; 17702746; 17708612; 17726647; 17846873; 17849363; 17891137; 17911438; 17914409; 17919613; 17940137; 17945212; 17945213; 17975002; 17987038; 18005092; 18029348; 18048043; 18077444; 18092951; 18094716; 18155656; 18160820; 18162778; 18193058; 18199543; 18214619; 18227732; 18234849; 18246799; 18265895; 18276068; 18279620; 18326820; 18350162; 18372518; 18375392; 18387829; 18396641; 18414895; 18415803; 18438684; 18441325; 18450428; 18450824; 18476625; 18476632; 18495204; 18502033; 18502153; 18513329; 18516325; 18559090; 18577517; 18608209; 18612220; 18614011; 18632604; 18644869; 18651220; 18654930; 18662989; 18753140; 18757307; 18787423; 18804101; 18804988; 18835619; 18852874; 18952835; 18971959; 18980968; 18981124; 18997126; 19004834; 19009655; 19010227; 19017033; 19017937; 19023892; 19047049; 19073595; 19077409; 19088176; 19097357; 19100415; 19141242; 19148550; 19167378; 19176383; 19199708; 19200980; 19243022; 19254252; 19275586; 19277703; 19322201; 19331807; 19350388; 19351367; 19360323; 19385591; 19396460; 19415765; 19416960; 19432801; 19434087; 19488035; 19506034; 19563418; 19577615; 19580891; 19582779; 19598259; 19621595; 19626493; 19633292; 19635906; 19638429; 19698232; 19703720; 19724852; 19764564; 19773544; 19787202; 19787231; 19794081; 19794958; 19794964; 19799609; 19816074; 19826051; 19857547; 19906290; 19912362; 19913121; 19914206; 19937401; 19952968; 19955840; 19965872; 19996285; 20019840; 20042890; 20083228; 20093404; 20093489; 20098615; 20121756; 20127679; 20142144; 20157733; 20178130; 20193563; 20199686; 20200161; 20211062; 20212041; 20228222; 20237496; 20306693; 20357818; 20361869; 20374021; 20382854; 20403620; 20405247; 20416163; 20454640; 20491779; 20525896; 20526812; 20530438; 20552237; 20562647; 20588206; 20605145; 20606680; 20606732; 20628086; 20628624; 20663864; 20663884; 20670691; 20696077; 20698358; 20799279; 20806065; 20809185; 20819778; 20837694; 20843027; 20851866; 20856229; 20920234; 20956971; 20962267; 20969572; 20971508; 20974992; 21055388; 21078678; 21087933; 21098716; 21105049; 21124918; 21136024; 21139048; 21151997; 21179550; 21194677; 21215700; 21254647; 21257828; 21257905; 21258793; 21278261; 21279958; 21294926; 21299347; 21331451; 21356346; 21374592; 21376257; 21393860; 21397861; 21411116; 21424816; 21454519; 21471214; 21471434; 21473743; 21482826; 21489997; 21493336; 21546273; 21570715; 21617876; 21618131; 21618132; 21630198; 21632186; 21633165; 21645921; 21649540; 21668410; 21678082; 21680714; 21685938; 21694464; 21701559; 21708929; 21718681; 21731740; 21743962; 21749678; 21764578; 21768115; 21768350; 21802218; 21804359; 21813394; 21819617; 21824412; 21827751; 21829201; 21830016; 21833756; 21835433; 21849440; 21895545; 21898409; 21906983; 21912471; 21933023; 21935375; 21935404; 21953074; 21957977; 21963094; 21987572; 21993315; 22014860; 22021370; 22024057; 22048598; 22068886; 22069487; 22072421; 22076958; 22119814; 22119938; 22125838; 22130902; 22135720; 22152097; 22205660; 22213301; 22216242; 22218639; 22234250; 22237177; 22242150; 22266115; 22270319; 22271686; 22272243; 22278305; 22293754; 22304920; 22307465; 22321833; 22322379; 22335271; 22363471; 22386367; 22389315; 22429811; 22433859; 22437554; 22449225; 22456539; 22473523; 22491449; 22493711; 22499789; 22514625; 22525501; 22552294; 22552741; 22559040; 22561518; 22610405; 22610780; 22621373; 22637644; 22654106; 22673507; 22673910; 22706704; 22711991; 22726066; 22733437; 22740085; 22740326; 22753277; 22770970; 22784357; 22804494; 22807608; 22836803; 22839505; 22842095; 22843930; 22847005; 22855175; 22863883; 22865879; 22870202; 22895075; 22901285; 22922740; 22923071; 22923171; 22932199; 22939629; 22947857; 22966907; 22967445; 22969228; 22972620; 23000965; 23002207; 23028444; 23031255; 23039365; 23049743; 23056168; 23071680; 23089492; 23098472; 23112116; 23118219; 23138176; 23143465; 23151220; 23160198; 23170789; 23171677; 23182705; 23220849; 23221384; 23226410; 23238743; 23251004; 23252868; 23263849; 23265944; 23273568; 23326564; 23334333; 23342032; 23373240; 23400010; 23404221; 23419168; 23422486; 23426175; 23435135; 23444222; 23445749; 23449937; 23457460; 23476138; 23547049; 23549458; 23565227; 23589287; 23589310; 23600676; 23603511; 23609373; 23633482; 23645762; 23664487; 23667174; 23679813; 23685894; 23736812; 23744486; 23764310; 23768762; 23778530; 23797812; 23800986; 23848514; 23856463; 23883608; 23884413; 23888049; 23940692; 24005673; 24064218; 24084461; 24091662; 24099991; 24194636; 24333422; 24434386
CD44 molecule (Indian blood group)
Ensembl:ENSG00000026508
HGNC:1681
HPRD:00115
MIM:107269
Vega:OTTHUMG00000044388
Other designations: CD44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|cell surface glycoprotein CD44|chondroitin sulfate proteoglycan 8|epican|extracellular matrix receptor III|hematopoietic cell E- and L-selectin ligand|heparan sulfate proteoglycan|homing function and Indian blood group system|hyaluronate receptor|phagocytic glycoprotein 1
CD44
Bin Zhao, Yue Liu, Oliver He
CDC2
CDC28A
P34CDC2
WEB: http://www.ncbi.nlm.nih.gov/gene
CDK1
cyclin-dependent kinase 1
983
10q21.1
20140408
9606
10
protein-coding
Official from a nomenclature committee
GO_0000082 (EC: TAS); GO_0000083 (EC: TAS); GO_0000086 (EC: TAS); GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0000187 (EC: TAS); GO_0000226 (EC: TAS); GO_0000278 (EC: TAS); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004672 (EC: NAS, PMID: 9001210); GO_0004674 (EC: IDA, PMID: 19879842); GO_0004693 (EC: IDA, PMID: 11069302); GO_0004693 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10373560); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005739 (EC: TAS, PMID: 19917720); GO_0005815 (EC: IEA); GO_0005829 (EC: TAS); GO_0005876 (EC: IDA, PMID: 11069302); GO_0006260 (EC: TAS); GO_0006281 (EC: TAS); GO_0006461 (EC: IEA); GO_0006915 (EC: IEA); GO_0007067 (EC: IEA); GO_0007077 (EC: TAS); GO_0007095 (EC: IEA); GO_0007098 (EC: TAS, PMID: 19364923); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007344 (EC: TAS); GO_0007411 (EC: TAS); GO_0007569 (EC: IEA); GO_0008286 (EC: TAS); GO_0008353 (EC: IDA, PMID: 12721286); GO_0008543 (EC: TAS); GO_0009636 (EC: IEA); GO_0010628 (EC: IEA); GO_0014038 (EC: TAS, PMID: 17200138); GO_0014070 (EC: IEA); GO_0014075 (EC: IEA); GO_0014823 (EC: IEA); GO_0016477 (EC: TAS, PMID: 17200138); GO_0018105 (EC: IDA, PMID: 19879842); GO_0030261 (EC: IEA); GO_0030332 (EC: IEA); GO_0030496 (EC: IDA, PMID: 11069302); GO_0030544 (EC: IEA); GO_0030855 (EC: IEP); GO_0031100 (EC: IEA); GO_0031145 (EC: TAS); GO_0033160 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0034501 (EC: IDA, PMID: 18195732); GO_0035173 (EC: IEA); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042493 (EC: IEA); GO_0043066 (EC: IDA, PMID: 11069302); GO_0045087 (EC: TAS); GO_0045471 (EC: IEA); GO_0045740 (EC: IEA); GO_0045931 (EC: IEA); GO_0045995 (EC: TAS); GO_0046686 (EC: IEA); GO_0046688 (EC: IEA); GO_0048011 (EC: TAS); GO_0048678 (EC: IEA); GO_0051403 (EC: TAS); GO_0051437 (EC: TAS); GO_0051439 (EC: TAS); GO_0055015 (EC: IEA); GO_0060045 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070301 (EC: IEA)
PMID: 914146; 1310466; 1318195; 1384126; 1388288; 1400350; 1406653; 1425574; 1628647; 1717476; 1748630; 1756735; 1828290; 1916766; 1939057; 2013279; 2183353; 2227411; 2344612; 2473839; 2538242; 2541912; 2570636; 2686978; 3289755; 3553962; 7474080; 7474100; 7494303; 7499230; 7578274; 7590285; 7592773; 7635160; 7666531; 7673335; 7716549; 7724583; 7737117; 7769006; 7790358; 7799941; 7822264; 7876309; 7902715; 7903056; 7925482; 7944411; 7949095; 7969176; 7983050; 8034666; 8051108; 8051175; 8070405; 8084605; 8087847; 8119945; 8125092; 8127873; 8242750; 8325880; 8376365; 8397206; 8397207; 8404858; 8423786; 8428596; 8440392; 8463339; 8475101; 8491187; 8524869; 8548803; 8565853; 8626512; 8626527; 8631817; 8652557; 8662825; 8663071; 8672508; 8806671; 8910336; 9001210; 9053846; 9069267; 9094673; 9109675; 9126608; 9130708; 9141461; 9188632; 9199321; 9235942; 9242535; 9244350; 9247342; 9258347; 9268380; 9271440; 9295339; 9315091; 9315635; 9398320; 9467962; 9515786; 9520381; 9524113; 9525956; 9560267; 9575153; 9585407; 9600099; 9614189; 9668078; 9725910; 9733650; 9753325; 9774639; 9885575; 9891079; 9926943; 9988268; 9990288; 10077596; 10339564; 10359664; 10362260; 10373560; 10383391; 10395539; 10403367; 10497277; 10502411; 10504341; 10524633; 10564259; 10602502; 10636877; 10656688; 10712923; 10716937; 10747892; 10764745; 10766737; 10767298; 10769027; 10793135; 10825186; 10864927; 10884347; 10924145; 10938080; 10958988; 10973963; 11034995; 11069302; 11076863; 11076968; 11113134; 11113184; 11135364; 11136719; 11259605; 11278541; 11278991; 11285280; 11310559; 11326318; 11327730; 11331587; 11395479; 11444800; 11470801; 11504921; 11516829; 11520933; 11531413; 11549262; 11559705; 11574543; 11584018; 11598127; 11683421; 11687586; 11774038; 11779217; 11782384; 11836499; 11861764; 11878934; 11895447; 11901153; 11953320; 11980914; 11986303; 12058066; 12077309; 12107172; 12124778; 12145207; 12151413; 12177195; 12186947; 12190313; 12200623; 12221128; 12361598; 12372621; 12397081; 12407107; 12411508; 12450396; 12468530; 12477932; 12525641; 12551973; 12556484; 12569090; 12569365; 12586835; 12604359; 12612056; 12612082; 12613668; 12648761; 12676926; 12721286; 12742823; 12771130; 12775724; 12791267; 12810701; 12832492; 12839990; 12852856; 12853968; 12881709; 12884029; 12912980; 14499622; 14551205; 14635192; 14645578; 14654553; 14697231; 14993212; 15014043; 15016823; 15024056; 15030318; 15050687; 15070733; 15073847; 15082718; 15125835; 15142377; 15145941; 15147269; 15175024; 15181148; 15215233; 15265780; 15276183; 15311285; 15317660; 15345747; 15367677; 15368451; 15474478; 15489334; 15489336; 15525513; 15525677; 15531913; 15541388; 15578977; 15582998; 15591787; 15592455; 15604258; 15635413; 15662526; 15674323; 15678101; 15725353; 15735702; 15735705; 15767402; 15780175; 15782160; 15790566; 15800651; 15817944; 15888452; 15951569; 15989971; 16009130; 16036217; 16109376; 16118207; 16142332; 16159883; 16192727; 16196087; 16198290; 16205633; 16226712; 16237118; 16247472; 16258277; 16344560; 16354571; 16371510; 16377132; 16381901; 16385451; 16407259; 16427064; 16458891; 16462731; 16465393; 16474839; 16478538; 16519687; 16533053; 16565220; 16629900; 16682949; 16760428; 16784539; 16807237; 16880735; 16880739; 16888198; 16998479; 17011204; 17012222; 17013563; 17043241; 17098733; 17159347; 17171635; 17172867; 17192257; 17200138; 17242184; 17274640; 17327911; 17349584; 17351640; 17359356; 17373700; 17386261; 17419986; 17431037; 17433108; 17466630; 17472438; 17474786; 17488622; 17498878; 17525531; 17540176; 17586317; 17636382; 17679094; 17681274; 17725712; 17906618; 17960875; 18003885; 18025303; 18029348; 18056802; 18069625; 18195732; 18201571; 18230152; 18245089; 18247328; 18271526; 18272572; 18272575; 18329369; 18337751; 18347064; 18356527; 18372919; 18408765; 18434602; 18445273; 18450493; 18457437; 18471975; 18477460; 18480403; 18490441; 18514189; 18550795; 18560763; 18568422; 18593881; 18615582; 18635963; 18655026; 18781797; 18799590; 18950845; 19048596; 19056867; 19061641; 19066288; 19134343; 19158392; 19162005; 19223178; 19275580; 19275583; 19275586; 19275588; 19303298; 19344781; 19364923; 19369249; 19375851; 19454010; 19458171; 19471022; 19473963; 19483727; 19509060; 19615732; 19664338; 19683496; 19687009; 19723060; 19725879; 19737929; 19738201; 19786724; 19789190; 19815027; 19837665; 19879842; 19884882; 19917720; 20062077; 20068230; 20068231; 20126263; 20169205; 20171170; 20181698; 20228808; 20360007; 20360068; 20367638; 20368335; 20368358; 20379221; 20395957; 20404109; 20412769; 20439461; 20444701; 20508983; 20526282; 20581839; 20711190; 20733055; 20739936; 20808790; 20810654; 20890132; 20935635; 20937773; 20956543; 20974803; 20974812; 21041660; 21059642; 21081492; 21081666; 21120602; 21123648; 21131960; 21135039; 21139048; 21148318; 21262764; 21308745; 21319273; 21325631; 21379580; 21406398; 21454540; 21488187; 21489275; 21498573; 21504622; 21522128; 21525341; 21569376; 21659531; 21693764; 21712819; 21743465; 21767532; 21813648; 21840486; 21871177; 21871181; 21875946; 21878504; 21878640; 21887332; 21890473; 21900237; 21900495; 21906983; 21907836; 21918813; 21924351; 21925791; 21951856; 21952639; 21963094; 21987572; 21987589; 21988832; 21998300; 22024133; 22053931; 22071694; 22101338; 22137483; 22158041; 22163316; 22266860; 22268729; 22407595; 22482362; 22496227; 22505724; 22552942; 22580043; 22623428; 22689984; 22718829; 22726437; 22768111; 22784093; 22814604; 22848730; 22863883; 22871736; 22907750; 22939629; 22949227; 22962268; 22965228; 23000965; 23045552; 23264621; 23330000; 23355470; 23383273; 23455152; 23471882; 23518499; 23525902; 23532886; 23543736; 23602568; 23619525; 23667531; 23720738; 23738518; 23775624; 23776131; 23814058; 23824909; 23901111; 23908594; 23921553; 23933584; 23956138; 23958962; 23966160; 23990466; 24101154; 24137814; 24248602; 24250222; 24457600
cyclin-dependent kinase 1
Ensembl:ENSG00000170312
HGNC:1722
HPRD:00302
MIM:116940
Vega:OTTHUMG00000018290
Other designations: cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
CDK1
Bin Zhao, Yue Liu, Oliver He
E2-CDC34
UBC3
UBCH3
UBE2R1
WEB: http://www.ncbi.nlm.nih.gov/gene
CDC34
cell division cycle 34
997
19p13.3
9606
19
Official from a nomenclature committee
GO_0000082 (EC: NAS, PMID: 8248134); GO_0000209 (EC: IDA); GO_0004842 (EC: IDA, PMID: 10373550); GO_0004842 (EC: NAS, PMID: 8248134); GO_0005515 (EC: IPI, PMID: 10373550); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005634 (EC: NAS, PMID: 8248134); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006270 (EC: NAS, PMID: 8248134); GO_0006464 (EC: NAS, PMID: 8248134); GO_0016567 (EC: IDA, PMID: 10373550); GO_0016567 (EC: NAS, PMID: 8248134); GO_0043161 (EC: IDA, PMID: 10373550); GO_0043525 (EC: IEA); GO_0043951 (EC: IDA, PMID: 10373550); GO_0070848 (EC: IEA); GO_0070936 (EC: IDA); GO_0090261 (EC: IEA)
PMID: 8248134; 8576261; 8939846; 9367342; 9430629; 9710583; 10329681; 10373550; 10385629; 10531035; 10713156; 10748083; 10769200; 10871850; 10918611; 11032804; 11054541; 11245432; 11463388; 11546811; 11566883; 11675391; 11689688; 12037680; 12060736; 12435635; 12477932; 12565873; 12813041; 12840033; 14532120; 14578910; 14645576; 14671314; 14690596; 14980219; 15327770; 15489334; 15611064; 15652359; 16123592; 16210246; 16322693; 16338364; 16472766; 16774918; 16861890; 16874460; 17274640; 17461777; 17597759; 17698585; 17785450; 17965458; 18029348; 18239684; 18458088; 18851830; 18950845; 19073596; 19084516; 19112177; 19123975; 19126550; 19240061; 19256485; 19471022; 19549727; 19581926; 19615732; 19875449; 19933270; 19945379; 20081843; 20160477; 20347421; 20353940; 20378537; 20379614; 20596027; 20638939; 20639865; 20663873; 20864041; 21098119; 21130766; 21139048; 21220517; 21296085; 21841822; 21890473; 21906983; 21963094; 22017877; 22053931; 22069333; 22087249; 22113614; 22145905; 22190037; 22210895; 22286100; 22334663; 22496338; 22669845; 22711876; 22748924; 22863883; 22959436; 23000965; 23250430; 23261596; 23297342; 23465077; 23478441; 23589337; 23604317; 23624912; 23910095; 23972993; 24129577; 24250222
cell division cycle 34
Ensembl:ENSG00000099804
HGNC:1734
HPRD:00306
MIM:116948
Vega:OTTHUMG00000180558
Other designations: cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
CDC34
Bin Zhao, Yue Liu, Oliver He
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
WEB: http://www.ncbi.nlm.nih.gov/gene
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
1026
6p21.2
9606
6
Official from a nomenclature committee
GO_0000079 (EC: TAS, PMID: 8242751); GO_0000082 (EC: IDA, PMID: 10208428); GO_0000082 (EC: TAS); GO_0000086 (EC: IMP, PMID: 17553787); GO_0000278 (EC: TAS); GO_0000307 (EC: IDA, PMID: 17420273); GO_0004861 (EC: TAS, PMID: 7958916); GO_0005515 (EC: IPI, PMID: 15232106); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: TAS); GO_0006468 (EC: IDA, PMID: 9106657); GO_0006974 (EC: IMP); GO_0006977 (EC: IDA, PMID: 15149599); GO_0006977 (EC: TAS); GO_0007050 (EC: IDA, PMID: 15149599); GO_0007050 (EC: IMP, PMID: 17553787); GO_0007173 (EC: TAS); GO_0007265 (EC: IEP, PMID: 9054499); GO_0008285 (EC: IDA, PMID: 10208428); GO_0008285 (EC: IMP, PMID: 17553787); GO_0008543 (EC: TAS); GO_0009411 (EC: IEA); GO_0009636 (EC: IEA); GO_0010243 (EC: IEA); GO_0010629 (EC: IEA); GO_0019912 (EC: IDA, PMID: 9106657); GO_0030308 (EC: IDA, PMID: 10208428); GO_0030332 (EC: IEA); GO_0030890 (EC: IEA); GO_0031100 (EC: IEA); GO_0031668 (EC: IMP, PMID: 17553787); GO_0032403 (EC: IEA); GO_0033158 (EC: IEA); GO_0038095 (EC: TAS); GO_0042326 (EC: IDA, PMID: 10208428); GO_0042493 (EC: IEA); GO_0042771 (EC: IEA); GO_0043066 (EC: IEA); GO_0043068 (EC: IEA); GO_0043231 (EC: IDA); GO_0045087 (EC: TAS); GO_0045736 (EC: IEA); GO_0045860 (EC: IDA, PMID: 9106657); GO_0046685 (EC: IEA); GO_0046872 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048146 (EC: IMP, PMID: 17420273); GO_0051412 (EC: IEA); GO_0055093 (EC: IEA); GO_0070557 (EC: IDA, PMID: 18794347); GO_0071479 (EC: IMP); GO_0071850 (EC: IEA); GO_0090398 (EC: IMP, PMID: 15149599); GO_0090400 (EC: TAS); GO_0097193 (EC: TAS, PMID: 9660939); GO_2000278 (EC: IEA); GO_2000379 (EC: IMP)
PMID: 7478582; 7478594; 7655464; 7698009; 7753561; 7780738; 7911228; 7958916; 8084608; 8101826; 8125163; 8242751; 8242752; 8259214; 8560263; 8622677; 8641969; 8647134; 8657154; 8662825; 8700517; 8756624; 8807325; 8861913; 8861969; 8891332; 8999999; 9054499; 9106657; 9178907; 9190208; 9218599; 9372966; 9380407; 9396813; 9464540; 9465025; 9467962; 9472014; 9515786; 9545252; 9546435; 9632134; 9658399; 9660939; 9705499; 9716181; 9716736; 9736735; 9798959; 9799125; 9811456; 9822382; 9837900; 9840927; 9840943; 9858585; 9858587; 10022118; 10022926; 10208428; 10323868; 10337545; 10455148; 10486249; 10529385; 10581175; 10679299; 10692450; 10698951; 10710306; 10753973; 10764767; 10828884; 10837373; 10848585; 10858286; 10873631; 10874474; 10878006; 10891505; 10912791; 10918595; 10973963; 11022036; 11076863; 11084299; 11132966; 11175348; 11179504; 11231585; 11254741; 11255227; 11302688; 11313979; 11343236; 11350925; 11389691; 11463845; 11477082; 11498536; 11559705; 11642719; 11684722; 11695244; 11700040; 11733969; 11741909; 11748297; 11751405; 11751903; 11756412; 11762751; 11781193; 11809712; 11815410; 11842244; 11860939; 11872638; 11877274; 11877298; 11877436; 11882322; 11893252; 11896572; 11908736; 11911463; 11931757; 11943869; 11953864; 11956602; 11968052; 11989975; 12015083; 12025230; 12036888; 12046058; 12052868; 12054510; 12054572; 12054658; 12055678; 12058028; 12111504; 12123335; 12138103; 12145325; 12151346; 12151347; 12151395; 12168821; 12204872; 12205674; 12354776; 12359245; 12361598; 12370305; 12379120; 12383116; 12384701; 12388558; 12392301; 12393707; 12396717; 12400017; 12407107; 12412576; 12417334; 12417722; 12429910; 12431783; 12431987; 12434183; 12441075; 12457968; 12459877; 12474524; 12477932; 12485998; 12513833; 12517948; 12519780; 12522211; 12527941; 12531694; 12545156; 12573582; 12599217; 12612054; 12642873; 12644083; 12651158; 12665570; 12665584; 12680256; 12681289; 12690110; 12698196; 12699883; 12705898; 12706118; 12716906; 12727210; 12727815; 12748190; 12771291; 12781424; 12782595; 12800980; 12809883; 12810668; 12820963; 12825853; 12839982; 12841870; 12847090; 12853982; 12855666; 12867429; 12884030; 12885947; 12890637; 12897156; 12930830; 12930846; 12931225; 12936910; 12947099; 12949733; 12963997; 12964161; 12970742; 13678583; 14504476; 14572899; 14574404; 14580260; 14592451; 14597617; 14607331; 14607337; 14628083; 14633995; 14637149; 14642618; 14647439; 14677632; 14702288; 14712207; 14715257; 14719078; 14726710; 14738489; 14744793; 14751560; 14759525; 14761977; 14762439; 14764039; 14981901; 15001356; 15003515; 15014036; 15016552; 15024057; 15033443; 15036662; 15059516; 15060836; 15069711; 15081425; 15082782; 15084259; 15094066; 15107488; 15111320; 15122333; 15142382; 15149599; 15161699; 15169570; 15171713; 15173090; 15179054; 15181148; 15184045; 15184659; 15190207; 15201954; 15201979; 15226418; 15232106; 15240512; 15251435; 15286705; 15291355; 15297421; 15302882; 15309711; 15317660; 15321712; 15340083; 15342418; 15347670; 15367606; 15371422; 15371446; 15378017; 15386430; 15389598; 15456784; 15474507; 15475071; 15489334; 15489336; 15492264; 15497017; 15509808; 15510615; 15528212; 15546622; 15555546; 15557281; 15574338; 15576034; 15580267; 15582998; 15592362; 15598783; 15606307; 15609309; 15616584; 15623356; 15645120; 15647383; 15660129; 15664193; 15665589; 15665816; 15671036; 15674334; 15674341; 15690394; 15694358; 15694838; 15695403; 15708847; 15709169; 15710329; 15716956; 15735102; 15736438; 15738655; 15743033; 15743834; 15746092; 15750619; 15752352; 15753078; 15756520; 15763542; 15764647; 15765097; 15767448; 15776189; 15780936; 15780937; 15798220; 15807891; 15817070; 15819981; 15839202; 15840769; 15856024; 15866118; 15878916; 15880444; 15880942; 15890360; 15893728; 15905168; 15936816; 15942645; 15944261; 15960923; 15964852; 15964998; 15965232; 15972853; 15975933; 15989967; 16009130; 16012716; 16014176; 16054204; 16078010; 16080520; 16081043; 16082198; 16082224; 16091736; 16111738; 16122475; 16135801; 16142303; 16142340; 16149052; 16150942; 16169070; 16182613; 16189514; 16191374; 16199872; 16200730; 16214366; 16226712; 16243918; 16248979; 16254341; 16256947; 16262255; 16276353; 16280359; 16283431; 16287849; 16288006; 16289646; 16343435; 16344056; 16344560; 16364249; 16381901; 16394138; 16432835; 16434701; 16464125; 16474839; 16479163; 16480585; 16507767; 16510448; 16514663; 16533812; 16551699; 16554660; 16580634; 16581770; 16616141; 16678112; 16705171; 16712793; 16718778; 16723699; 16735508; 16765349; 16775840; 16777994; 16782892; 16803887; 16804724; 16804901; 16818630; 16831599; 16835890; 16837471; 16867219; 16951143; 16952553; 16953367; 16964243; 16982699; 17008550; 17014852; 17016640; 17050675; 17054950; 17055654; 17059853; 17062672; 17072949; 17074759; 17079232; 17079872; 17080297; 17080554; 17108107; 17109628; 17115032; 17130157; 17158927; 17172426; 17172832; 17188136; 17203174; 17214516; 17239344; 17273559; 17283049; 17284535; 17286201; 17292858; 17293600; 17293864; 17294043; 17300726; 17303651; 17317670; 17325029; 17337084; 17339230; 17351341; 17371838; 17373842; 17388661; 17409409; 17420273; 17431791; 17438369; 17443496; 17448597; 17460193; 17460194; 17465503; 17477906; 17498252; 17502456; 17513615; 17517622; 17536310; 17553787; 17556661; 17560543; 17585201; 17588519; 17592292; 17595776; 17606716; 17611661; 17616661; 17617120; 17619016; 17627285; 17634558; 17638911; 17641414; 17656367; 17662641; 17671089; 17671689; 17671727; 17679094; 17682292; 17684142; 17686574; 17692879; 17700068; 17721438; 17804869; 17855660; 17873065; 17885207; 17894409; 17911387; 17920036; 17925548; 17937105; 17941827; 17952758; 17972508; 18004740; 18024214; 18025091; 18035504; 18046503; 18049450; 18057010; 18067855; 18071305; 18086887; 18097575; 18156402; 18162471; 18162533; 18166158; 18172194; 18174230; 18174243; 18181833; 18202757; 18203777; 18205772; 18212054; 18215742; 18226366; 18230337; 18243530; 18251939; 18263614; 18278446; 18281511; 18281541; 18292944; 18298387; 18316600; 18334933; 18339845; 18348176; 18353898; 18358634; 18361427; 18374497; 18385383; 18385759; 18386236; 18400748; 18413741; 18427550; 18441278; 18451802; 18456456; 18458079; 18459109; 18463164; 18498065; 18507837; 18508827; 18509005; 18546941; 18559599; 18562088; 18563330; 18583941; 18593937; 18619950; 18632985; 18644983; 18655775; 18664350; 18694622; 18698027; 18703516; 18710616; 18713757; 18719376; 18765563; 18766473; 18782865; 18788572; 18790797; 18791688; 18794347; 18794348; 18798266; 18806827; 18818310; 18823025; 18829543; 18842998; 18850004; 18850315; 18852884; 18923142; 18941111; 18948188; 18949380; 18950845; 18979138; 18981726; 19001415; 19002614; 19033664; 19041685; 19058005; 19064572; 19091404; 19096232; 19102934; 19106607; 19122196; 19124506; 19125693; 19129183; 19134409; 19141585; 19159630; 19161984; 19176223; 19176530; 19177004; 19211566; 19211842; 19221506; 19223555; 19224585; 19237173; 19243472; 19249676; 19258477; 19262578; 19263441; 19269967; 19273588; 19275888; 19276188; 19276356; 19305381; 19321391; 19322021; 19322654; 19329556; 19330811; 19332548; 19339270; 19356250; 19364816; 19367277; 19383287; 19384944; 19407849; 19409758; 19435914; 19452712; 19453261; 19458054; 19465901; 19465904; 19481339; 19487575; 19491257; 19491398; 19502805; 19505915; 19513497; 19528229; 19536092; 19536131; 19538940; 19541625; 19550124; 19557639; 19560419; 19572978; 19578553; 19581932; 19609363; 19626602; 19628749; 19629483; 19635457; 19638413; 19643983; 19657064; 19657726; 19664338; 19667069; 19668373; 19670700; 19672706; 19686092; 19686743; 19692168; 19693773; 19704162; 19713748; 19723065; 19723093; 19723627; 19730150; 19732026; 19738611; 19750108; 19773351; 19789190; 19795398; 19798054; 19802676; 19818775; 19819988; 19820361; 19822666; 19840446; 19855935; 19860623; 19895794; 19910837; 19913121; 19914103; 19921577; 19923826; 19931389; 19935879; 19950226; 19955391; 19956635; 19956888; 19958256; 20006705; 20012529; 20018861; 20025780; 20039273; 20054616; 20062013; 20062063; 20067556; 20071335; 20079711; 20084294; 20086099; 20101223; 20102411; 20112071; 20126416; 20127253; 20139077; 20144199; 20154723; 20160708; 20164022; 20169278; 20179200; 20190802; 20190813; 20190815; 20193371; 20203690; 20204299; 20204303; 20211058; 20219912; 20301197; 20302655; 20303835; 20308078; 20331843; 20347598; 20349127; 20350217; 20351180; 20357201; 20363991; 20369488; 20370687; 20383190; 20388787; 20419447; 20428774; 20433229; 20444901; 20452353; 20453000; 20458559; 20466633; 20495378; 20504375; 20508865; 20510020; 20510146; 20524403; 20544840; 20583115; 20587660; 20598695; 20600642; 20605778; 20606006; 20622899; 20628086; 20644561; 20668328; 20701798; 20702488; 20732856; 20803550; 20813048; 20814747; 20818156; 20844987; 20858736; 20878079; 20890119; 20954283; 20955243; 20966541; 20979563; 21040707; 21046779; 21048031; 21054888; 21076409; 21087528; 21088000; 21098705; 21115898; 21124069; 21127431; 21139048; 21148311; 21165952; 21242961; 21245169; 21262772; 21288367; 21292770; 21308745; 21311948; 21325273; 21325288; 21325480; 21336720; 21342417; 21358637; 21368573; 21383005; 21402054; 21415438; 21415862; 21417953; 21419318; 21430453; 21437722; 21439247; 21443127; 21460037; 21475302; 21478095; 21511729; 21515331; 21526487; 21532626; 21546904; 21552210; 21554918; 21559393; 21561680; 21565979; 21567397; 21575583; 21608063; 21616632; 21628527; 21637851; 21637966; 21642427; 21652709; 21666704; 21677879; 21685936; 21704589; 21709715; 21725088; 21726628; 21729169; 21768776; 21769863; 21780161; 21791360; 21804532; 21820300; 21832049; 21858171; 21870644; 21875573; 21877955; 21887277; 21890473; 21900206; 21903579; 21906983; 21907315; 21918011; 21933447; 21933903; 21938741; 21956786; 21963094; 21976111; 21988832; 22001409; 22002313; 22009857; 22032898; 22101335; 22110135; 22117196; 22135025; 22147197; 22160829; 22172947; 22173494; 22190353; 22199295; 22206000; 22211246; 22214381; 22216119; 22217266; 22227369; 22244827; 22249270; 22262409; 22266309; 22277651; 22291954; 22296117; 22311974; 22320961; 22321971; 22371483; 22383522; 22392074; 22401965; 22427654; 22428663; 22446964; 22449259; 22469187; 22490020; 22503977; 22510560; 22511267; 22511763; 22514271; 22521293; 22547059; 22547681; 22555846; 22615960; 22634755; 22650359; 22662213; 22673765; 22675167; 22683204; 22684370; 22698403; 22711822; 22713239; 22732402; 22735451; 22751124; 22771799; 22797886; 22814028; 22814742; 22820403; 22828875; 22858377; 22859066; 22869584; 22956625; 22964432; 22980580; 22988851; 22995373; 22997714; 23000965; 23007394; 23007395; 23013131; 23026136; 23034899; 23037503; 23066038; 23085750; 23085987; 23128396; 23133524; 23146670; 23153928; 23158659; 23159636; 23160381; 23167335; 23167427; 23169665; 23178572; 23184467; 23187802; 23208500; 23210340; 23211592; 23213251; 23215027; 23219618; 23224600; 23231583; 23236067; 23238566; 23253087; 23255119; 23261596; 23261678; 23271730; 23275116; 23292332; 23306062; 23306186; 23318451; 23324739; 23329847; 23333058; 23349794; 23349842; 23359201; 23375502; 23376845; 23382584; 23383273; 23388456; 23399735; 23449391; 23455922; 23457546; 23458879; 23463857; 23536437; 23555284; 23577194; 23582783; 23590292; 23601845; 23602568; 23603558; 23618860; 23639631; 23645206; 23652278; 23665236; 23684928; 23715767; 23737759; 23745637; 23759594; 23780339; 23807750; 23832541; 23832542; 23856463; 23928864; 23949224; 24027428; 24074410; 24076166; 24082141; 24119401; 24123000; 24134839; 24217248; 24225749; 24244542; 24277930; 24291038; 24379070
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Ensembl:ENSG00000124762
HGNC:1784
HPRD:00298
MIM:116899
Vega:OTTHUMG00000014603
Other designations: CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1
CDKN1A
Bin Zhao, Yue Liu, Oliver He
C/EBP-delta
CELF
CRP3
NF-IL6-beta
WEB: http://www.ncbi.nlm.nih.gov/gene
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
1052
8p11.2-p11.1
9606
8
Official from a nomenclature committee
GO_0003700 (EC: IEA); GO_0005634 (EC: IEA); GO_0006366 (EC: TAS, PMID: 8314590); GO_0043565 (EC: IEA)
PMID: 1638120; 1741402; 1840554; 1884998; 7594592; 7789168; 8314590; 8946919; 9570146; 11741938; 11851384; 12177065; 12477932; 12524424; 12554732; 12825852; 12857754; 12937035; 15212823; 15389878; 15389879; 15486993; 15588942; 15674331; 15718495; 15901830; 16195339; 16322893; 16397300; 16914534; 16997058; 17098861; 17234736; 17373909; 17562792; 17903252; 17910034; 18370833; 18477566; 18619497; 18660489; 18753137; 19471022; 19800021; 19806320; 19811452; 20385105; 20460359; 20467438; 20805509; 20829351; 20971808; 21072181; 21076392; 21112127; 21612582; 21666710; 21693764; 21980073; 22037769; 23028973; 23575666; 23603433; 23861541; 24128855; 24155666
CCAAT/enhancer binding protein (C/EBP), delta
HGNC:1835
HPRD:00297
MIM:116898
Other designations: CCAAT/enhancer-binding protein delta|c/EBP delta|nuclear factor NF-IL6-beta
CEBPD
Bin Zhao, Yue Liu, Oliver He
CENP-E
KIF10
PPP1R61
WEB: http://www.ncbi.nlm.nih.gov/gene
CENPE
centromere protein E, 312kDa
1062
4q24-q25
9606
4
Official from a nomenclature committee
GO_0000089 (EC: TAS, PMID: 2022189); GO_0000278 (EC: TAS); GO_0000775 (EC: IDA, PMID: 11084331); GO_0000776 (EC: IDA, PMID: 11682612); GO_0000778 (EC: IEA); GO_0000779 (EC: IDA, PMID: 19465021); GO_0000940 (EC: TAS, Qualifier: colocalizes_with, PMID: 9763420); GO_0003777 (EC: IMP, PMID: 7889940); GO_0005515 (EC: IPI, PMID: 17535814); GO_0005524 (EC: IEA); GO_0005634 (EC: IMP, PMID: 9763420); GO_0005737 (EC: IDA); GO_0005819 (EC: IEA); GO_0005829 (EC: TAS); GO_0005871 (EC: IEA); GO_0005874 (EC: IDA, PMID: 7889940); GO_0007018 (EC: TAS); GO_0007079 (EC: TAS, PMID: 1406971); GO_0007080 (EC: TAS, PMID: 9363944); GO_0007275 (EC: IEA); GO_0007596 (EC: TAS); GO_0008017 (EC: IEA); GO_0008152 (EC: IMP, PMID: 7889940); GO_0015630 (EC: IDA); GO_0019886 (EC: TAS); GO_0043515 (EC: IDA, PMID: 9763420); GO_0045860 (EC: IMP, PMID: 12925705); GO_0051382 (EC: NAS, PMID: 9763420)
PMID: 1406971; 2022189; 7851898; 7889940; 9363944; 9391217; 9744883; 9763420; 9914370; 10477750; 10852915; 11084331; 11337467; 11682612; 12686615; 12925705; 12938929; 14684825; 15146197; 15159587; 15181147; 15236970; 15297875; 16144904; 16196087; 16565220; 16682006; 16926026; 17081983; 17268814; 17370265; 17535814; 18029348; 18342609; 18374647; 18460473; 19389623; 19465021; 19525938; 19553660; 19625775; 19723035; 19733075; 19779646; 20021663; 20085233; 20237434; 20332099; 20354862; 20360068; 20691903; 21139048; 21282530; 22110139; 22307330; 22637578; 22801780; 22974711; 23236152; 23314748; 23666240; 23955301
centromere protein E, 312kDa
Ensembl:ENSG00000138778
HGNC:1856
HPRD:00316
MIM:117143
Vega:OTTHUMG00000160980
Other designations: Centromere autoantigen E (312kD)|centromere-associated protein E|kinesin family member 10|kinesin-related protein CENPE|protein phosphatase 1, regulatory subunit 61
CENPE
Bin Zhao, Yue Liu, Oliver He
AP19
CLAPS1
EKV3
MEDNIK
SIGMA1A
WUGSC:H_DJ0747G18.2
WEB: http://www.ncbi.nlm.nih.gov/gene
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
1174
7q22.1
9606
7
Official from a nomenclature committee
GO_0000139 (EC: TAS); GO_0005765 (EC: TAS); GO_0005829 (EC: TAS); GO_0005905 (EC: IEA); GO_0006886 (EC: IEA); GO_0006892 (EC: TAS); GO_0006898 (EC: TAS, PMID: 9733768); GO_0008565 (EC: IEA); GO_0009615 (EC: IEP, PMID: 16548883); GO_0016032 (EC: TAS); GO_0019886 (EC: TAS); GO_0030121 (EC: TAS, PMID: 9733768); GO_0030659 (EC: TAS); GO_0032588 (EC: TAS); GO_0050690 (EC: TAS); GO_0061024 (EC: TAS)
PMID: 2040623; 7593184; 9653655; 9733768; 9736718; 9811606; 9811611; 9847074; 9882340; 10535737; 10747088; 10966473; 11031247; 11222723; 11252894; 11463741; 11694590; 11707398; 12215646; 12477932; 12486136; 12836198; 12853948; 15469849; 15489334; 15569716; 15681409; 16253302; 16548883; 17353931; 18336259; 18781797; 19057675; 19149577; 19895210; 20594957; 21139048; 21762802; 21906983; 21963094; 21987572; 22103831; 22939629; 23000965; 23423674; 23956138; 24250222
adaptor-related protein complex 1, sigma 1 subunit
Ensembl:ENSG00000106367
HGNC:559
HPRD:04635
MIM:603531
Vega:OTTHUMG00000157103
Other designations: AP-1 complex subunit sigma-1A|HA1 19 kDa subunit|adapter-related protein complex 1 sigma-1A subunit|adapter-related protein complex 1 subunit sigma-1A|adaptor protein complex AP-1 subunit sigma-1A|clathrin assembly protein complex 1 sigma-1A small chain|clathrin coat assembly protein AP19|clathrin-associated/assembly/adaptor protein, small 1 (19kD)|erythrokeratodermia variabilis 3 (Kamouraska type)|golgi adaptor HA1/AP1 adaptin sigma-1A subunit|sigma1A subunit of AP-1 clathrin adaptor complex|sigma1A-adaptin
AP1S1
Bin Zhao, Yue Liu, Oliver He
APO-J
APOJ
CLI
CLU1
CLU2
KUB1
NA1/NA2
SGP-2
SGP2
SP-40
TRPM-2
TRPM2
WEB: http://www.ncbi.nlm.nih.gov/gene
CLU
clusterin
1191
AAG4
8p21-p12
9606
8
Official from a nomenclature committee
GO_0001836 (EC: IC, PMID: 16113678); GO_0002576 (EC: TAS); GO_0005515 (EC: IPI, PMID: 16113678); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 11123922); GO_0005634 (EC: IEA); GO_0005739 (EC: IDA, PMID: 16113678); GO_0005783 (EC: IEA); GO_0005829 (EC: IEA); GO_0006629 (EC: NAS, PMID: 2387851); GO_0006956 (EC: TAS, PMID: 1585460); GO_0006958 (EC: IEA); GO_0007596 (EC: TAS); GO_0009615 (EC: IEP, PMID: 16548883); GO_0016887 (EC: IDA, Qualifier: NOT, PMID: 11123922); GO_0030168 (EC: TAS); GO_0031012 (EC: IDA, Qualifier: colocalizes_with); GO_0031093 (EC: TAS); GO_0031625 (EC: IDA); GO_0031966 (EC: IEA); GO_0032436 (EC: IMP); GO_0032463 (EC: IMP, PMID: 16113678); GO_0034366 (EC: IDA, PMID: 16682745); GO_0042583 (EC: IEA); GO_0043065 (EC: IMP); GO_0043691 (EC: TAS, PMID: 16682745); GO_0045087 (EC: IEA); GO_0048471 (EC: IDA); GO_0050821 (EC: IDA, PMID: 11123922); GO_0051092 (EC: IMP); GO_0051787 (EC: IDA, PMID: 11123922); GO_0051787 (EC: IPI, PMID: 19996109); GO_0051788 (EC: IDA, PMID: 19996109); GO_0061077 (EC: IDA, PMID: 11123922); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072562 (EC: IDA); GO_0097193 (EC: IDA); GO_1902230 (EC: IMP, PMID: 16113678); GO_2000060 (EC: IMP); GO_2001244 (EC: IMP)
PMID: 1424805; 1491011; 1551440; 1585460; 1903064; 1924317; 1974459; 2185274; 2387851; 2454950; 2601725; 2721499; 2780565; 2780570; 3154963; 3167096; 7615015; 7626703; 7768901; 8181474; 8292612; 8314591; 8328966; 8345200; 8387101; 8555189; 8634259; 8752142; 8759347; 8843912; 8889548; 9228033; 9336835; 9537999; 10066740; 10219089; 10329371; 10694874; 11123922; 11186422; 11570883; 11714447; 11795992; 11813210; 11892985; 11904161; 11906815; 12082621; 12172907; 12176985; 12200037; 12393179; 12427144; 12429802; 12470829; 12477932; 12551933; 12679903; 12754519; 12824284; 12860995; 12867999; 12882985; 14618611; 14630798; 14702039; 14718574; 14760718; 15033782; 15133840; 15146195; 15158456; 15174051; 15247015; 15252304; 15304052; 15342556; 15389725; 15480429; 15489334; 15492264; 15499376; 15538973; 15591223; 15649646; 15689620; 15791650; 15809754; 15883054; 15925890; 15929184; 15955107; 16113678; 16179938; 16263699; 16331665; 16335952; 16421571; 16464517; 16490286; 16548883; 16675913; 16682745; 16709604; 16709934; 16740002; 16775601; 16806233; 16955214; 17043677; 17048076; 17056579; 17080454; 17148459; 17170699; 17203891; 17224269; 17260971; 17322305; 17407782; 17412999; 17420006; 17451556; 17512083; 17534116; 17535098; 17689225; 17855704; 17872975; 17974975; 18079682; 18082619; 18097679; 18239862; 18378577; 18458059; 18514801; 18542050; 18612545; 18624398; 18649357; 18709641; 18712185; 18714397; 18786636; 18806885; 18813793; 18842294; 19056867; 19118032; 19137541; 19165232; 19166932; 19177010; 19182256; 19220628; 19264665; 19289586; 19344414; 19353783; 19357365; 19391138; 19413638; 19446882; 19535339; 19542874; 19651157; 19664600; 19734902; 19734903; 19757199; 19793084; 19814590; 19878569; 19878770; 19878774; 19879420; 19879421; 19879422; 19879423; 19903339; 19903745; 19935703; 19940549; 19996109; 20000738; 20007348; 20009887; 20019877; 20028970; 20057494; 20058210; 20068069; 20096688; 20195357; 20209083; 20353268; 20360068; 20410100; 20460622; 20497247; 20534741; 20554627; 20570404; 20599866; 20603455; 20614220; 20674675; 20697030; 20738160; 20739100; 20842452; 20847305; 20850846; 20855565; 20873220; 20930273; 21042904; 21043527; 21059989; 21135756; 21163940; 21224044; 21240462; 21242307; 21280673; 21300948; 21347408; 21379329; 21397462; 21422520; 21447104; 21460841; 21460853; 21467232; 21467285; 21505792; 21508640; 21525168; 21527247; 21543606; 21567405; 21573492; 21627779; 21630085; 21633299; 21732348; 21761117; 21824521; 21892414; 21899841; 21900379; 21912625; 21953030; 21953454; 21980627; 21987172; 21988832; 21998749; 22012253; 22013110; 22015308; 22016805; 22068036; 22082661; 22122982; 22130675; 22145905; 22159129; 22166956; 22179788; 22232000; 22234156; 22236192; 22248099; 22258514; 22266332; 22268729; 22274961; 22296908; 22391565; 22402018; 22465014; 22506010; 22532874; 22539578; 22545109; 22569264; 22613415; 22617144; 22647452; 22689054; 22701550; 22795969; 22832520; 22863883; 22889670; 22896337; 22902018; 22906254; 22952074; 22975582; 22981431; 22990118; 23010347; 23051594; 23099883; 23174100; 23201481; 23208459; 23209684; 23276503; 23279642; 23411014; 23416242; 23455922; 23457489; 23538443; 23573206; 23589125; 23602568; 23621580; 23650005; 23673647; 23702390; 23769013; 23770713; 23786771; 23956692; 24073260
clusterin
Ensembl:ENSG00000120885
HGNC:2095
HPRD:01706
MIM:185430
Vega:OTTHUMG00000102114
Other designations: aging-associated protein 4|apolipoprotein J|complement cytolysis inhibitor|complement lysis inhibitor|complement-associated protein SP-40,40|ku70-binding protein 1|sulfated glycoprotein 2|testosterone-repressed prostate message 2
CLU
Bin Zhao, Yue Liu, Oliver He
CD191
CKR-1
CKR1
CMKBR1
HM145
MIP1aR
SCYAR1
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR1
chemokine (C-C motif) receptor 1
1230
3p21
9606
3
GO_0002407 (EC: TAS, PMID:16621978); GO_0004435 (EC: IDA, PMID:10734056); GO_0004950 (EC: IDA, PMID:10660125); GO_0005515 (EC: IPI, PMID:15001559); GO_0005886 (EC: IDA, PMID:10660125); GO_0005886 (EC: IMP, PMID:15001559); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:7505609); GO_0006816 (EC: IDA, PMID:10734056); GO_0006874 (EC: IDA, PMID:10734056); GO_0006887 (EC: IDA, PMID:10734056); GO_0006935 (EC: NAS, PMID:15474493); GO_0006954 (EC: IEA); GO_0006955 (EC: IDA, PMID:10734056); GO_0007155 (EC: TAS, PMID:10910894); GO_0007166 (EC: TAS, PMID:10770925); GO_0007187 (EC: TAS, PMID:7505609); GO_0007204 (EC: IDA, PMID:10734056); GO_0007267 (EC: IDA, PMID:10734056); GO_0008152 (EC: IDA, PMID:10734056); GO_0009611 (EC: TAS, PMID:7505609); GO_0009897 (EC: IDA, PMID:10706735); GO_0010629 (EC: IMP); GO_0016493 (EC: IDA, PMID:10734056); GO_0019221 (EC: NAS, PMID:15474493); GO_0019957 (EC: IPI, PMID:10660125); GO_0030502 (EC: IMP); GO_0035717 (EC: IPI, PMID:10660125); GO_0045672 (EC: IMP); GO_0051928 (EC: IDA, PMID:15764707); GO_0070098 (EC: IDA); GO_0070374 (EC: IMP); GO_0071791 (EC: IPI, PMID:10660125); GO_0090026 (EC: IDA, PMID:18587271)
PMID:2834384; 7505609; 7545673; 7594543; 7679328; 7683036; 8011297; 8530354; 8626727; 8631787; 8699119; 9115216; 9143512; 9289016; 9346309; 9558365; 9886417; 10094132; 10202040; 10583963; 10660125; 10702689; 10706735; 10734056; 10770925; 10910894; 11085751; 11110672; 11116158; 11449371; 11470772; 11804551; 11832479; 11920567; 12070001; 12085329; 12270118; 12477932; 12651617; 12763925; 12794150; 14530297; 14595653; 14637022; 14674010; 15001559; 15039444; 15053339; 15103513; 15265234; 15337751; 15474493; 15489334; 15548526; 15764707; 15927850; 15950672; 16182378; 16226254; 16323127; 16621978; 16837468; 16969502; 17135764; 17192849; 17298994; 17336272; 17389578; 17464174; 17558413; 17914560; 18178867; 18240029; 18311140; 18559339; 18577758; 18587271; 18972130; 19017998; 19423540; 19553544; 19603542; 19664396; 19687291; 19693089; 19913121; 20015385; 20056178; 20086017; 20154287; 20190752; 20406964; 20429924; 20438785; 20628086; 20634891; 20802378; 20921899; 21148810; 21942940; 22007486; 22104149; 22650026; 22727097; 22829007; 22842622; 23054685; 23125416; 23217400; 23219091; 23233369; 23276697; 23291587; 24056371
chemokine (C-C motif) receptor 1
Ensembl:ENSG00000163823
HGNC:1602
HPRD:03101
MIM:601159
Vega:OTTHUMG00000133451
Other designations: C-C CKR-1|C-C chemokine receptor type 1|CC-CKR-1|CCR-1|LD78 receptor|MIP-1alpha-R|RANTES receptor|RANTES-R|macrophage inflammatory protein 1-alpha receptor
CCR1
Bin Zhao, Yue Liu, Oliver He
CC-CKR-3
CD193
CKR3
CMKBR3
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR3
chemokine (C-C motif) receptor 3
1232
3p21.3
9606
3
GO_0001938 (EC: IEA); GO_0004950 (EC: TAS, PMID:10415069); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:9302298); GO_0006935 (EC: IEA); GO_0006954 (EC: IEA); GO_0006968 (EC: TAS, PMID:10713092); GO_0007155 (EC: TAS, PMID:10201960); GO_0007188 (EC: TAS, PMID:10201960); GO_0007204 (EC: TAS, PMID:9302298); GO_0016032 (EC: IEA); GO_0016493 (EC: IEA); GO_0045766 (EC: IMP, PMID:19525930); GO_0070098 (EC: TAS, PMID:10415069)
PMID:7594543; 7622448; 8609214; 8631813; 8631926; 8642344; 8674119; 8676064; 8884276; 9005985; 9024664; 9143512; 9182688; 9252350; 9289016; 9302298; 9346309; 9359702; 9419219; 9573273; 9636210; 9653051; 9712872; 9736741; 9765440; 9789057; 10094132; 10201960; 10415069; 10488147; 10514402; 10527858; 10590105; 10642580; 10666479; 10713092; 10877489; 10900353; 10975800; 11001881; 11085751; 11110785; 11115360; 11120849; 11149986; 11196669; 11307756; 11396683; 11449371; 11832479; 11920572; 11991282; 11994538; 12023397; 12079287; 12149192; 12218106; 12393570; 12397598; 12477932; 12654630; 12794150; 12884299; 12902471; 14581140; 14647058; 14702039; 14733956; 15053339; 15086398; 15194768; 15219825; 15476879; 15489334; 15507393; 15580493; 15607028; 15807893; 15857508; 15992849; 16081847; 16174786; 16470129; 16631222; 16712896; 16904155; 16920975; 17041228; 17135764; 17146638; 17672867; 17703412; 17845580; 17983872; 18240029; 18244953; 18311140; 18379861; 18577758; 18636124; 18676680; 18805825; 18974840; 19017998; 19028820; 19131662; 19170196; 19218218; 19247692; 19258923; 19414538; 19423540; 19525930; 19526283; 19542083; 19553323; 19559392; 19625176; 19692168; 19693089; 19714638; 19731977; 20022477; 20056178; 20144207; 20190752; 20220260; 20237496; 20306659; 20364559; 20380698; 20406964; 20438785; 20503287; 20505746; 20603037; 20647273; 20659406; 20726325; 20734064; 20921899; 20923436; 21041734; 21077277; 21143381; 21280323; 21406396; 21660963; 21735070; 21917937; 22086059; 22217447; 22702503; 22829007; 22842622; 23017229; 23054685; 23183094; 23251661; 23291587; 23566847; 23636060; 23643185; 23702389; 23742077; 23955446
chemokine (C-C motif) receptor 3
Ensembl:ENSG00000183625
HGNC:1604
HPRD:03167
MIM:601268
Vega:OTTHUMG00000133484
Other designations: C-C CKR-3|C-C chemokine receptor type 3|CC chemokine receptor 3|CCR-3|b-chemokine receptor|eosinophil CC chemokine receptor 3|eosinophil eotaxin receptor
CCR3
Bin Zhao, Yue Liu, Oliver He
CC-CKR-4
CD194
CKR4
CMKBR4
ChemR13
HGCN:14099
K5-5
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR4
chemokine (C-C motif) receptor 4
1233
3p24
9606
3
GO_0001764 (EC: IEA); GO_0002507 (EC: IEA); GO_0004950 (EC: TAS, PMID:7642634); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:7642634); GO_0006935 (EC: IEA); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0007204 (EC: TAS, PMID:7642634); GO_0009314 (EC: IEA); GO_0009617 (EC: IEA); GO_0009897 (EC: IEA); GO_0016493 (EC: IEA); GO_0043025 (EC: IEA); GO_0046677 (EC: IEA); GO_0050927 (EC: IEA); GO_0070098 (EC: TAS, PMID:7642634)
PMID:7642634; 8573157; 8884276; 9169480; 9430724; 9743322; 9933589; 10036181; 10466728; 10754297; 11196669; 11861261; 12070001; 12270118; 12406880; 12429730; 12456591; 12477932; 12485447; 12778466; 14657875; 15187160; 15202833; 15328188; 15489334; 15569983; 15621800; 15857508; 15955100; 17071491; 17117949; 17546636; 18071306; 18240029; 18577758; 18782672; 19106589; 19239991; 19244125; 19261691; 19374191; 19423540; 19903885; 19913121; 19942450; 20148806; 20164417; 20190752; 20237293; 20237496; 20334681; 20364559; 20406964; 20412707; 20438785; 20628086; 20963786; 21443538; 21525208; 21739422; 22490506; 22842622; 23180648; 23644599; 23731651; 24127572
chemokine (C-C motif) receptor 4
HGNC:1605
HPRD:05324
MIM:604836
Other designations: C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4
CCR4
Bin Zhao, Yue Liu, Oliver He
CC-CKR-5
CCCKR5
CCR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
1234
3p21.31
9606
3
GO_0000165 (EC: IEP, PMID:12032188); GO_0001974 (EC: IEA); GO_0002407 (EC: TAS, PMID:16621978); GO_0003779 (EC: IDA, PMID:12421915); GO_0004435 (EC: TAS, PMID:8663314); GO_0004950 (EC: TAS, PMID:10201901); GO_0005515 (EC: IPI, PMID:12421915); GO_0005737 (EC: TAS, PMID:10415069); GO_0005768 (EC: IDA, PMID:10679098); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:10393923); GO_0006816 (EC: IDA, PMID:8699119); GO_0006935 (EC: TAS, PMID:10741397); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0006968 (EC: TAS, PMID:10201901); GO_0007166 (EC: TAS, PMID:8639485); GO_0007186 (EC: IMP, PMID:19523456); GO_0007204 (EC: TAS, PMID:10201901); GO_0007267 (EC: IDA, PMID:10679098); GO_0009897 (EC: IDA, PMID:10679098); GO_0009986 (EC: IDA, PMID:10521508); GO_0014808 (EC: IDA, PMID:19523456); GO_0015026 (EC: TAS, PMID:10469138); GO_0016032 (EC: TAS); GO_0016493 (EC: IDA, PMID:11278962); GO_0016493 (EC: NAS, PMID:8639485); GO_0019722 (EC: IDA, PMID:10679098); GO_0019957 (EC: IPI, PMID:10679098); GO_0023052 (EC: IEP, PMID:12032188); GO_0030260 (EC: TAS); GO_0070098 (EC: IDA, PMID:11278962); GO_0070098 (EC: NAS, PMID:8639485); GO_0070098 (EC: TAS, PMID:10201901); GO_0070723 (EC: IMP, PMID:19523456); GO_0071222 (EC: IEP, PMID:10679098); GO_0071791 (EC: IPI, PMID:8699119); GO_0090026 (EC: IEA)
PMID:2183196; 2564392; 2569467; 2834384; 3346208; 3512269; 3960725; 8639485; 8649511; 8649512; 8663314; 8674119; 8699119; 8751444; 8756719; 8805353; 8898753; 8906795; 8906796; 8976200; 8995603; 9020356; 9031325; 9143512; 9184207; 9188565; 9207783; 9256481; 9261346; 9261451; 9289016; 9334377; 9343222; 9353123; 9359654; 9359702; 9362541; 9388201; 9399903; 9420225; 9420238; 9445013; 9446638; 9468473; 9525683; 9576751; 9576954; 9632396; 9636210; 9653051; 9653130; 9765440; 9870313; 9882290; 9882373; 9890944; 9971818; 10029247; 10037796; 10085131; 10089882; 10200301; 10201901; 10229873; 10339592; 10357469; 10364178; 10370370; 10384144; 10393923; 10393974; 10413516; 10415069; 10438703; 10438870; 10446313; 10449282; 10453044; 10465086; 10469138; 10477567; 10477718; 10482561; 10482572; 10487781; 10497246; 10505675; 10521508; 10527688; 10544150; 10555208; 10559284; 10562492; 10574939; 10585143; 10590105; 10590121; 10602038; 10602409; 10606089; 10623731; 10640778; 10644351; 10679098; 10702689; 10725362; 10738970; 10741397; 10751368; 10758170; 10775626; 10801487; 10807185; 10816381; 10820198; 10823934; 10826481; 10872839; 10877489; 10882583; 10888615; 10888639; 10917742; 10938094; 10961858; 10970739; 10985308; 11005830; 11023492; 11023526; 11024154; 11069996; 11072599; 11085751; 11086073; 11115360; 11116158; 11118070; 11125885; 11125899; 11134270; 11141322; 11153675; 11162839; 11175286; 11177400; 11181160; 11188946; 11196681; 11196706; 11238869; 11263244; 11264152; 11264346; 11264367; 11265761; 11274729; 11278567; 11278738; 11278962; 11290759; 11312658; 11313374; 11334429; 11335892; 11336643; 11342415; 11350939; 11354628; 11356952; 11356961; 11356967; 11369664; 11377705; 11385319; 11390601; 11393656; 11397808; 11398114; 11403814; 11413305; 11414813; 11427892; 11429110; 11447384; 11448957; 11449371; 11464139; 11468147; 11470772; 11477473; 11484163; 11485305; 11485615; 11489906; 11500196; 11504955; 11511825; 11517394; 11529558; 11543895; 11559423; 11591716; 11595595; 11596075; 11602715; 11679153; 11679916; 11689632; 11693435; 11694103; 11696224; 11698270; 11698699; 11700073; 11703822; 11709091; 11709782; 11711617; 11727771; 11729511; 11733580; 11734558; 11751947; 11752157; 11756347; 11781692; 11803051; 11809184; 11856781; 11859127; 11860793; 11860823; 11861850; 11861874; 11873082; 11876757; 11877445; 11878912; 11901272; 11920312; 11920324; 11937056; 11958683; 11964548; 11966764; 11966770; 11988632; 11994442; 11994538; 12001056; 12010355; 12023175; 12032188; 12032878; 12036855; 12055576; 12056598; 12065593; 12070001; 12082592; 12085329; 12091904; 12093918; 12131184; 12136242; 12140749; 12163044; 12163614; 12166499; 12169668; 12176010; 12183462; 12200385; 12201365; 12202222; 12215252; 12239139; 12271718; 12355376; 12356205; 12368322; 12377943; 12378793; 12403355; 12403770; 12408990; 12412204; 12413885; 12421915; 12426392; 12426393; 12426633; 12427015; 12429730; 12437612; 12445801; 12447757; 12451219; 12461425; 12462338; 12477875; 12477932; 12490404; 12496074; 12509908; 12514416; 12522035; 12531905; 12532229; 12551992; 12552446; 12555203; 12556692; 12557141; 12571248; 12571520; 12579509; 12584049; 12586555; 12587636; 12599073; 12610055; 12610158; 12612298; 12612937; 12619446; 12634405; 12651900; 12667818; 12680626; 12688247; 12689409; 12692222; 12726730; 12745546; 12751031; 12767984; 12788308; 12798016; 12815099; 12819030; 12829440; 12837756; 12846056; 12853745; 12857973; 12858455; 12865070; 12871111; 12873764; 12873765; 12874407; 12882661; 12884524; 12887913; 12887918; 12913933; 12915585; 12925765; 12960231; 12960247; 12963807; 12964123; 14501804; 14505910; 14517611; 14533004; 14533983; 14576050; 14581567; 14583186; 14597737; 14616291; 14624371; 14636691; 14637022; 14644028; 14645006; 14647058; 14672331; 14673528; 14674010; 14694113; 14697747; 14715575; 14716309; 14742283; 14963124; 14981141; 14982745; 14990703; 15000812; 15001559; 15004773; 15009175; 15016843; 15039132; 15047829; 15076247; 15080861; 15086346; 15086398; 15113926; 15117454; 15124759; 15125257; 15135805; 15140377; 15169555; 15180829; 15181567; 15192272; 15192276; 15215889; 15230854; 15236615; 15242539; 15251452; 15258189; 15279544; 15280786; 15288441; 15301862; 15302103; 15307921; 15308751; 15319853; 15321703; 15331395; 15354329; 15362666; 15385740; 15458467; 15465089; 15479838; 15488313; 15489334; 15500552; 15548261; 15557916; 15566517; 15575507; 15577536; 15585333; 15586413; 15588345; 15591779; 15592455; 15596839; 15602133; 15610230; 15629079; 15639953; 15650194; 15651660; 15708547; 15725749; 15737629; 15754978; 15757671; 15767435; 15767436; 15769362; 15787642; 15793360; 15793370; 15802968; 15807900; 15821335; 15851912; 15854903; 15856455; 15857992; 15863470; 15882964; 15885315; 15890935; 15902300; 15916792; 15932625; 15950936; 15958832; 15962231; 15964018; 15964389; 15972662; 15976369; 15980670; 15980693; 15981170; 15983047; 15985194; 15992849; 16015368; 16034118; 16055130; 16100775; 16118671; 16140745; 16144840; 16157597; 16161154; 16174786; 16179731; 16182378; 16196460; 16206074; 16233918; 16248677; 16249462; 16249700; 16261210; 16270124; 16284527; 16286055; 16300985; 16305685; 16312181; 16314800; 16323127; 16335661; 16344560; 16358723; 16375941; 16378977; 16395252; 16405836; 16418398; 16442182; 16461193; 16476734; 16476981; 16478397; 16480760; 16481131; 16485782; 16501811; 16512757; 16513874; 16524739; 16529059; 16541097; 16545485; 16547971; 16598837; 16614115; 16621960; 16621978; 16631222; 16633049; 16641997; 16672419; 16672549; 16702010; 16703416; 16721228; 16721558; 16764352; 16774544; 16775617; 16807236; 16817962; 16841089; 16847113; 16855620; 16865553; 16872485; 16879946; 16887960; 16888899; 16909455; 16916647; 16937446; 16943294; 16960780; 16963439; 16966601; 16999868; 16999983; 17030448; 17053144; 17053352; 17060059; 17063508; 17067435; 17079285; 17091019; 17094383; 17101151; 17101166; 17112859; 17121788; 17135764; 17145599; 17147503; 17148969; 17166523; 17169533; 17202224; 17207111; 17210123; 17214851; 17237417; 17240189; 17255952; 17257590; 17261788; 17273779; 17301575; 17305874; 17306322; 17328229; 17329448; 17331026; 17331851; 17346133; 17351762; 17355643; 17361671; 17383752; 17411375; 17413295; 17417600; 17426779; 17428349; 17442950; 17445875; 17460174; 17462514; 17465678; 17507467; 17507486; 17511851; 17522201; 17530006; 17560067; 17564248; 17565662; 17582634; 17585540; 17596666; 17604289; 17607321; 17620369; 17625759; 17627030; 17633563; 17640964; 17644519; 17645788; 17653092; 17671738; 17672867; 17675516; 17686153; 17691823; 17703412; 17713445; 17722977; 17786209; 17845302; 17855336; 17855654; 17884183; 17901336; 17909797; 17920529; 17929678; 17952079; 17963165; 17971448; 17971457; 17977968; 17984846; 17989610; 18036244; 18060801; 18076768; 18094161; 18096812; 18097239; 18160142; 18162443; 18179388; 18179389; 18182569; 18189189; 18191728; 18194353; 18195571; 18197127; 18203956; 18205260; 18205925; 18218038; 18230715; 18240029; 18242797; 18255039; 18295459; 18296630; 18311470; 18346864; 18353949; 18353956; 18361062; 18379014; 18386165; 18391751; 18405329; 18436884; 18453587; 18462992; 18468560; 18480458; 18480460; 18490657; 18498240; 18500445; 18511806; 18524826; 18543610; 18577758; 18588983; 18590744; 18611987; 18619974; 18623133; 18629619; 18632580; 18633131; 18648518; 18673537; 18676680; 18689270; 18691022; 18692212; 18706447; 18753930; 18763111; 18776933; 18781860; 18786994; 18814951; 18815295; 18820725; 18845960; 18846999; 18855658; 18923649; 18925934; 18928397; 18941536; 18949389; 18952441; 18972295; 18974840; 18977142; 18989363; 18991615; 19005677; 19017985; 19017998; 19018669; 19028820; 19032065; 19037908; 19050382; 19064579; 19064722; 19098363; 19116725; 19124913; 19129082; 19129457; 19131662; 19143484; 19149577; 19155524; 19170196; 19170639; 19172482; 19196047; 19200444; 19201454; 19212663; 19218218; 19225544; 19247692; 19250219; 19258923; 19260142; 19263529; 19289833; 19297481; 19321618; 19334035; 19339951; 19339953; 19357773; 19389855; 19402700; 19420105; 19433914; 19460331; 19474452; 19476483; 19479237; 19479371; 19506371; 19520154; 19523456; 19535121; 19538721; 19553544; 19559392; 19561149; 19578796; 19585516; 19603542; 19625176; 19625411; 19644155; 19644158; 19669591; 19679608; 19680536; 19692168; 19692476; 19692480; 19700905; 19706316; 19722264; 19729379; 19740335; 19744036; 19744740; 19769961; 19811270; 19811439; 19816596; 19841162; 19864932; 19874552; 19886839; 19894308; 19913121; 19917679; 19950235; 19956635; 19958843; 20018238; 20025530; 20025985; 20038229; 20050936; 20053336; 20068218; 20075058; 20087947; 20107582; 20130232; 20153665; 20169157; 20174557; 20182805; 20190752; 20203694; 20206716; 20220260; 20237496; 20331378; 20334567; 20364409; 20377425; 20378664; 20381825; 20411675; 20420684; 20442634; 20442662; 20453841; 20463745; 20465832; 20503287; 20507591; 20518834; 20530467; 20531015; 20536507; 20570309; 20594957; 20598754; 20603037; 20608170; 20628086; 20628649; 20682662; 20710056; 20729133; 20801883; 20811274; 20842205; 20855251; 20856130; 20861743; 20865789; 20875295; 20921899; 20923564; 20932773; 20969781; 21041313; 21068438; 21084992; 21091093; 21118814; 21132346; 21134114; 21148810; 21152581; 21155586; 21156032; 21188555; 21248683; 21258050; 21280323; 21284403; 21288812; 21288824; 21288827; 21295814; 21325401; 21330910; 21345957; 21349294; 21354457; 21356539; 21362450; 21381021; 21388649; 21396623; 21429204; 21454526; 21465943; 21473821; 21513481; 21525208; 21555814; 21569409; 21573951; 21592988; 21602126; 21634220; 21637819; 21647388; 21655330; 21663455; 21667221; 21671175; 21676905; 21680525; 21696586; 21703201; 21709449; 21715437; 21723943; 21731496; 21739422; 21741662; 21744265; 21760891; 21763489; 21775441; 21789236; 21814863; 21819370; 21820915; 21835796; 21846359; 21859712; 21860345; 21878623; 21886032; 21890375; 21926353; 21926633; 21944757; 21984373; 21984929; 21988832; 22011385; 22024519; 22026334; 22028271; 22044225; 22047989; 22050776; 22069466; 22079021; 22083068; 22085486; 22102307; 22103833; 22103834; 22157596; 22175768; 22218121; 22264071; 22265023; 22282138; 22285384; 22286874; 22292949; 22297516; 22313935; 22314435; 22325341; 22342838; 22348061; 22374185; 22380870; 22392992; 22403408; 22404213; 22416573; 22424737; 22479344; 22496149; 22496885; 22506069; 22537745; 22547820; 22554649; 22554651; 22583417; 22612293; 22637726; 22638733; 22657741; 22665517; 22701041; 22727097; 22728273; 22732432; 22787219; 22808111; 22811524; 22815758; 22818666; 22830600; 22852142; 22862553; 22875513; 22893032; 22908191; 22918850; 22924548; 22933279; 22954962; 22957026; 22957692; 22966075; 22988032; 22994752; 23041556; 23057571; 23077246; 23115275; 23152559; 23185351; 23217182; 23217400; 23235831; 23250822; 23289212; 23298254; 23312573; 23355876; 23454776; 23480650; 23490419; 23493400; 23515570; 23588722; 23594959; 23632061; 23632983; 23643185; 23691059; 23696662; 23753295; 23773920; 23852305; 23856897; 23880174; 23888779; 23903010; 23936229; 23954573; 24030490; 24078580; 24090135; 24128342; 24129241; 24405814
chemokine (C-C motif) receptor 5 (gene/pseudogene)
Ensembl:ENSG00000160791
HGNC:1606
HPRD:03223
MIM:601373
Vega:OTTHUMG00000133481
Other designations: C-C chemokine receptor type 5|C-C motif chemokine receptor 5 A159A|HIV-1 fusion coreceptor|chemokine receptor CCR5|chemr13
CCR5
Bin Zhao, Yue Liu, Oliver He
BN-1
C-C CKR-6
CC-CKR-6
CCR-6
CD196
CKR-L3
CKRL3
CMKBR6
DCR2
DRY6
GPR29
GPRCY4
STRL22
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR6
chemokine (C-C motif) receptor 6
1235
6q27
9606
6
GO_0002407 (EC: TAS, PMID:16621978); GO_0004872 (EC: TAS, PMID:9186513); GO_0004950 (EC: TAS, PMID:11001880); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:9186513); GO_0006928 (EC: TAS, PMID:9186513); GO_0006935 (EC: TAS, PMID:11001880); GO_0006955 (EC: TAS, PMID:9223454); GO_0006959 (EC: TAS, PMID:11001880); GO_0006968 (EC: TAS, PMID:10521347); GO_0007165 (EC: TAS, PMID:9186513); GO_0007204 (EC: TAS, PMID:9223454); GO_0016493 (EC: IEA); GO_0045087 (EC: TAS); GO_0070098 (EC: TAS, PMID:11001880)
PMID:2834384; 8125298; 8886020; 9070937; 9169459; 9186513; 9223454; 9294137; 9294138; 10521347; 11001880; 11164896; 11714836; 11751947; 11994436; 12067311; 12070001; 12081481; 12149255; 12193700; 12477932; 12514792; 12642342; 14574404; 15483227; 15489334; 15591779; 15701269; 15972662; 16095490; 16215992; 16344560; 16621978; 16622267; 16641550; 17075975; 17133360; 17171755; 17562763; 17615381; 18097022; 18218038; 18240029; 18465142; 18577758; 18587394; 18703490; 19233848; 19249008; 19305396; 19324905; 19423540; 19492413; 19539215; 19760754; 19811428; 20022113; 20023216; 20056178; 20068036; 20194631; 20220766; 20334681; 20379614; 20406964; 20438785; 20439195; 20453841; 20453842; 20459729; 20483750; 20511548; 20526339; 20526340; 20570966; 20634891; 20720211; 20872189; 21072187; 21092675; 21102463; 21228329; 21261017; 21300824; 21398606; 21624121; 21724701; 21763254; 21873313; 21912453; 21935436; 21937703; 21949768; 21984702; 22079021; 22092173; 22269120; 22490506; 22732549; 22796894; 22842622; 22859539; 22926920; 23128233; 23306142; 23599932; 23681234; 23758411; 23765988; 23790181; 23850713; 23935994; 23983073
chemokine (C-C motif) receptor 6
Ensembl:ENSG00000112486
HGNC:1607
HPRD:03498
MIM:601835
Vega:OTTHUMG00000016015
Other designations: C-C chemokine receptor type 6|G protein-coupled receptor 29|G-protein coupled receptor 29|LARC receptor|chemokine (C-C) receptor 6|chemokine receptor-like 3|seven-transmembrane receptor, lymphocyte, 22
CCR6
Bin Zhao, Yue Liu, Oliver He
BLR2
CD197
CDw197
CMKBR7
EBI1
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR7
chemokine (C-C motif) receptor 7
1236
17q12-q21.2
9606
17
GO_0001768 (EC: IC, PMID:12729902); GO_0001954 (EC: IC, PMID:15569314); GO_0002407 (EC: IC, PMID:15778365); GO_0002408 (EC: IC, PMID:14592837); GO_0002606 (EC: ISS); GO_0002885 (EC: ISS); GO_0002922 (EC: ISS); GO_0004930 (EC: TAS, PMID:16621978); GO_0005622 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0006954 (EC: NAS, PMID:14592837); GO_0006955 (EC: IEA); GO_0007186 (EC: TAS, PMID:16621978); GO_0007204 (EC: TAS, PMID:9153236); GO_0009897 (EC: IEA); GO_0016021 (EC: IEA); GO_0016493 (EC: ISS); GO_0030838 (EC: IC, PMID:11242036); GO_0031274 (EC: IC, PMID:11242036); GO_0031529 (EC: IC, PMID:15569314); GO_0032496 (EC: IEA); GO_0032649 (EC: ISS); GO_0032735 (EC: ISS); GO_0032862 (EC: IC, PMID:15778365); GO_0034695 (EC: IC, PMID:14592837); GO_0035757 (EC: IPI, PMID:9507024); GO_0035758 (EC: IPI, PMID:9507024); GO_0038115 (EC: IDA, PMID:9507024); GO_0038116 (EC: IDA, PMID:9507024); GO_0038117 (EC: IDA, PMID:9507024); GO_0038121 (EC: IDA, PMID:9507024); GO_0043123 (EC: IC, PMID:15059845); GO_0043552 (EC: IC, PMID:15059845); GO_0045060 (EC: IEA); GO_0045785 (EC: IC, PMID:15569314); GO_0045860 (EC: IC, PMID:14592837); GO_0046330 (EC: IC, PMID:15778365); GO_0050706 (EC: ISS); GO_0050862 (EC: IEA); GO_0051209 (EC: IC, PMID:14592837); GO_0051491 (EC: IC, PMID:15569314); GO_0051897 (EC: IC, PMID:15059845); GO_0070098 (EC: ISS); GO_0070374 (EC: IC, PMID:12729902); GO_0071731 (EC: IC, PMID:16249377); GO_0072610 (EC: ISS); GO_0090023 (EC: IDA); GO_0097022 (EC: TAS, PMID:18379575); GO_0097029 (EC: ISS); GO_2000107 (EC: IC, PMID:15059845); GO_2000147 (EC: IC, PMID:15778365); GO_2000510 (EC: ISS); GO_2000522 (EC: ISS); GO_2000525 (EC: ISS); GO_2000526 (EC: ISS); GO_2000547 (EC: ISS)
PMID:2834384; 7488016; 7851893; 8383238; 8889548; 9153236; 9507024; 9585422; 9725259; 9743376; 10607681; 10706668; 10741397; 10861057; 11145663; 11242036; 11359797; 11507220; 11830455; 11861876; 11929789; 11970971; 12023337; 12070001; 12149218; 12477932; 12486098; 12642342; 12673677; 12729902; 12799021; 12851649; 14592837; 14990723; 15034011; 15040017; 15059845; 15073111; 15122702; 15247147; 15265234; 15284247; 15304089; 15489334; 15569314; 15674360; 15743472; 15753377; 15778365; 15867478; 15950936; 15972662; 16115904; 16223574; 16225771; 16249377; 16272303; 16278001; 16278374; 16278415; 16344560; 16494043; 16500130; 16621978; 16690519; 16786131; 16802356; 16857986; 16887149; 17006331; 17032700; 17178876; 17192395; 17431094; 17440035; 17587445; 17687340; 17890452; 18065728; 18166500; 18235009; 18240029; 18310327; 18319253; 18379575; 18437055; 18497951; 18544997; 18577758; 18623114; 18664492; 18696160; 18802075; 19068542; 19074885; 19087620; 19136936; 19196101; 19287948; 19423540; 19513547; 19536265; 19536742; 19540558; 19585516; 19615795; 19731977; 19749090; 19862774; 20029460; 20036791; 20056178; 20150960; 20237496; 20406964; 20438785; 20439195; 20651394; 20811680; 20855251; 20889506; 20889923; 21048031; 21071608; 21081040; 21092675; 21165563; 21165582; 21261017; 21347514; 21464944; 21548969; 21624121; 21680174; 21698152; 21731495; 21735098; 21739164; 21739671; 21953548; 22020953; 22043010; 22158872; 22163030; 22221265; 22251626; 22334704; 22350183; 22438908; 22498742; 22533989; 22619482; 22634622; 22659045; 22718198; 22797918; 22821963; 22842622; 22923218; 22990666; 23028633; 23290307; 23363813; 23449735; 23469143; 23498789; 23519840; 23747721; 23888080; 23922113; 24052640; 24136650; 24138884; 24311382
chemokine (C-C motif) receptor 7
Ensembl:ENSG00000126353
HGNC:1608
HPRD:02588
MIM:600242
Vega:OTTHUMG00000133375
Other designations: C-C CKR-7|C-C chemokine receptor type 7|CC chemokine receptor 7|CC-CKR-7|CCR-7|EBV-induced G protein-coupled receptor 1|EBV-induced G-protein coupled receptor 1|Epstein-Barr virus induced G-protein coupled receptor|Epstein-Barr virus induced gene 1|MIP-3 beta receptor|chemokine (C-C) receptor 7|epstein-Barr virus-induced G-protein coupled receptor 1|lymphocyte-specific G protein-coupled peptide receptor
CCR7
Bin Zhao, Yue Liu, Oliver He
CC-CKR-8
CCR-8
CDw198
CKRL1
CMKBR8
CMKBRL2
CY6
GPRCY6
TER1
WEB: http://www.ncbi.nlm.nih.gov/gene
CCR8
chemokine (C-C motif) receptor 8
1237
3p22
9606
3
GO_0004950 (EC: TAS, PMID:9417093); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID:8816377); GO_0006935 (EC: IEA); GO_0006955 (EC: IEA); GO_0007155 (EC: TAS, PMID:10910894); GO_0007186 (EC: TAS, PMID:8816377); GO_0007204 (EC: IEA); GO_0015026 (EC: TAS, PMID:9417093); GO_0016493 (EC: IEA); GO_0070098 (EC: TAS, PMID:9417093)
PMID:8816377; 8886020; 8977299; 9207005; 9211859; 9417093; 9469461; 9480837; 9521068; 9670926; 10469138; 10540332; 10888633; 10910894; 11007922; 11804551; 12163566; 12477932; 12525579; 12547701; 12551893; 12645948; 12832759; 12967681; 14576057; 15053339; 15489334; 15814739; 15992849; 16631222; 17023422; 17082609; 17558413; 17641040; 17693327; 18240029; 18577758; 19074885; 19423540; 20237496; 20406964; 20438785; 20455898; 21976223; 22479563; 22842622; 23043070; 23363815; 23999500
chemokine (C-C motif) receptor 8
Ensembl:ENSG00000179934
HGNC:1609
HPRD:03497
MIM:601834
Vega:OTTHUMG00000131290
Other designations: C-C chemokine receptor type 8|CC chemokine receptor 8|CC chemokine receptor CHEMR1|CC-chemokine receptor chemr1|chemokine (C-C) receptor 8|chemokine (C-C) receptor-like 2|chemokine receptor-like 1
CCR8
Bin Zhao, Yue Liu, Oliver He
ICH
POREN2
WEB: http://www.ncbi.nlm.nih.gov/gene
COL4A2
collagen, type IV, alpha 2
1284
RP11-90L1.2
13q34
9606
13
Official from a nomenclature committee
GO_0001525 (EC: IEA); GO_0005201 (EC: TAS, PMID: 8317999); GO_0005515 (EC: IPI, PMID: 12011424); GO_0005576 (EC: TAS); GO_0005587 (EC: TAS, PMID: 2846280); GO_0005788 (EC: TAS); GO_0006351 (EC: IEA); GO_0007411 (EC: TAS); GO_0016525 (EC: IDA, PMID: 10625665); GO_0022617 (EC: TAS); GO_0030198 (EC: NAS, PMID: 8317999); GO_0030198 (EC: TAS); GO_0030574 (EC: TAS); GO_0031012 (EC: IDA, Qualifier: colocalizes_with); GO_0031012 (EC: ISS, Qualifier: colocalizes_with); GO_0031012 (EC: TAS, Qualifier: colocalizes_with); GO_0043231 (EC: IDA); GO_0071560 (EC: IEA)
PMID: 1377218; 1724753; 2211625; 2426947; 2439508; 2844531; 2846280; 3025878; 3089234; 3182844; 3198637; 3345760; 3582677; 3692475; 3997552; 6389236; 6811420; 6988303; 7495302; 7500359; 7827955; 8006028; 8317999; 8995276; 9136074; 9334230; 9409248; 9506531; 9673377; 9878537; 10382266; 10416788; 10625665; 10926178; 11259413; 11683410; 11711546; 11867580; 12011424; 12021518; 12180907; 12477932; 12878203; 15057823; 15146197; 15231748; 15489334; 15522229; 15743801; 16368877; 16712791; 17216253; 17339318; 17554254; 17557121; 18050191; 18706356; 19481338; 19913121; 20067797; 20080650; 20201926; 20452482; 20628086; 20673868; 20805453; 20889312; 21378990; 21527998; 21900206; 21942715; 22144573; 22209246; 22209247; 22268729; 22333902; 23818951
collagen, type IV, alpha 2
Ensembl:ENSG00000134871
HGNC:2203
HPRD:00355
MIM:120090
Vega:OTTHUMG00000017344
Other designations: canstatin|collagen alpha-2(IV) chain
COL4A2
Bin Zhao, Yue Liu, Oliver He
BCD1
CBA1
COPEB
CPBP
GBF
PAC1
ST12
ZF9
WEB: http://www.ncbi.nlm.nih.gov/gene
KLF6
Kruppel-like factor 6
1316
RP11-184A2.1
10p15
9606
10
Official from a nomenclature committee
GO_0003677 (EC: IEA); GO_0005634 (EC: TAS, PMID: 9689109); GO_0005737 (EC: IEA); GO_0006351 (EC: IEA); GO_0019221 (EC: IEA); GO_0030183 (EC: NAS, PMID: 9000136); GO_0045893 (EC: TAS, PMID: 9083102); GO_0046872 (EC: IEA)
PMID: 8889548; 9000136; 9083102; 9503030; 9685731; 9689109; 10802067; 11752579; 12433697; 12477932; 12508640; 12590140; 12651597; 12651626; 12740910; 12794452; 15057748; 15064720; 15067324; 15131018; 15164054; 15172998; 15247715; 15342556; 15378003; 15486921; 15489334; 15735005; 15824733; 15917248; 15937668; 16044160; 16054710; 16169070; 16189514; 16385451; 16431954; 16500425; 16598737; 16702959; 16778100; 16856969; 16872311; 16972326; 16988269; 17071613; 17113081; 17125911; 17143513; 17207965; 17223258; 17347589; 17347668; 17514651; 17621627; 17636026; 17663506; 17893646; 18053161; 18174288; 18190240; 18250346; 18471523; 18515091; 18521079; 18596922; 18691883; 18719336; 18753303; 18755691; 18822210; 19020536; 19097929; 19101139; 19328586; 19333010; 19435908; 19808645; 19967571; 20014424; 20116377; 20126619; 20237496; 20453000; 20545576; 20660366; 20714872; 20801538; 20844588; 21056892; 21109018; 21154818; 21282102; 21309496; 21443094; 21470678; 21538018; 21799854; 21832049; 21849067; 21906983; 21928351; 21940380; 22095588; 22169644; 22277651; 22486562; 22535637; 22581522; 22653055; 22711891; 22782870; 22855058; 23048070; 23085750; 23219426; 23322324; 23345610; 23353867; 23508266; 23512538; 23831683; 23870195; 24130502
Kruppel-like factor 6
Ensembl:ENSG00000067082
HGNC:2235
HPRD:03632
MIM:602053
Vega:OTTHUMG00000017567
Other designations: B-cell-derived protein 1|GC-rich binding factor|GC-rich sites-binding factor GBF|Krueppel-like factor 6|Kruppel-like zinc finger protein Zf9|core promoter element binding protein|core promoter element-binding protein|proto-oncogene BCD1|protooncogene B-cell derived 1|suppression of tumorigenicity 12 (prostate)|suppressor of tumorigenicity 12 protein|transcription factor Zf9
KLF6
Bin Zhao, Yue Liu, Oliver He
COX6B
COXG
COXVIb1
WEB: http://www.ncbi.nlm.nih.gov/gene
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
1340
19q13.1
9606
19
Official from a nomenclature committee
GO_0004129 (EC: NAS, PMID: 2172092); GO_0005739 (EC: IDA); GO_0005743 (EC: TAS); GO_0005758 (EC: IEA); GO_0021762 (EC: IEP); GO_0022904 (EC: TAS); GO_0044237 (EC: TAS); GO_0044281 (EC: TAS); GO_1902600 (EC: NAS, PMID: 2172092)
PMID: 1647217; 1650756; 1651883; 2172092; 2537962; 7821789; 11943455; 12477932; 15057824; 15489334; 17353931; 17500595; 17516841; 18029348; 18499082; 19843159; 20877624; 21139048; 21890473; 21906983; 21963094; 22190034; 22419111; 22505724; 22939629; 23000965
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
Ensembl:ENSG00000126267
HGNC:2280
HPRD:00493
MIM:124089
Vega:OTTHUMG00000048112
Other designations: COX VIb-1|cytochrome c oxidase subunit 6B1
COX6B1
Bin Zhao, Yue Liu, Oliver He
CPT1-L
CPTI
L-CPT1
WEB: http://www.ncbi.nlm.nih.gov/gene
CPT1A
carnitine palmitoyltransferase 1A (liver)
1374
11q13.2
9606
22
Official from a nomenclature committee
GO_0004095 (EC: IEA); GO_0005739 (EC: IDA); GO_0005741 (EC: TAS); GO_0006635 (EC: IEA); GO_0006853 (EC: TAS); GO_0016021 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS)
PMID: 7892212; 9070836; 9070950; 9691089; 10408760; 11001805; 11095714; 11257506; 11350182; 11441142; 12111367; 12189492; 12464674; 12477932; 14517221; 14711372; 15489334; 15647998; 15669684; 15846373; 16054041; 16246309; 16271724; 16344560; 16697732; 16806233; 17089095; 17445541; 17452323; 18029348; 18253084; 18385088; 18996102; 19181627; 19217814; 19460752; 19913121; 20124555; 20301700; 20562859; 20602615; 20628086; 20638986; 20691246; 20696606; 20843525; 20877624; 20937660; 21139048; 21252943
carnitine palmitoyltransferase 1
Ensembl:ENSG00000110090
HGNC:2328
HPRD:02755
MIM:600528
Vega:OTTHUMG00000167892
CPT1A
Bin Zhao, Yue Liu, Oliver He
CPT1
CPTASE
IIAE4
WEB: http://www.ncbi.nlm.nih.gov/gene
CPT2
carnitine palmitoyltransferase 2
1376
1p32
9606
1
Official from a nomenclature committee
GO_0004095 (EC: NAS, PMID: 1988962); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005739 (EC: IDA); GO_0005743 (EC: NAS, PMID: 1988962); GO_0005743 (EC: TAS); GO_0006635 (EC: IEA); GO_0006853 (EC: TAS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS)
PMID: 1528846; 1961767; 1988962; 2174799; 7711730; 7892212; 7896283; 8086471; 8125298; 8358442; 8499929; 8651281; 9600456; 9758712; 10090476; 10607472; 11001805; 11095714; 11257506; 11477613; 11855939; 11994355; 12408750; 12410208; 12477932; 12707442; 12971426; 14605500; 14615409; 15489334; 15622536; 15642848; 15647998; 15754283; 16054041; 16168441; 16670153; 16671104; 16710414; 16996287; 17179390; 17651973; 17709715; 17936304; 18024217; 18029348; 18306170; 18363739; 18550408; 18645163; 18996102; 19362304; 19762733; 19913121; 20186120; 20301431; 20370797; 20538056; 20602615; 20628086; 20810031; 20877624; 20934285; 20952238; 21277129; 21641254; 21697855; 21913903; 22493507; 23322164; 23475205; 23566841
carnitine palmitoyltransferase 2
Ensembl:ENSG00000157184
HGNC:2330
HPRD:02802
MIM:600650
Vega:OTTHUMG00000008942
Other designations: CPT II|carnitine O-palmitoyltransferase 2, mitochondrial|carnitine palmitoyltransferase II
CPT2
Bin Zhao, Yue Liu, Oliver He
CRE-BP1
CREB-2
CREB2
HB16
TREB7
WEB: http://www.ncbi.nlm.nih.gov/gene
ATF2
activating transcription factor 2
1386
2q32
9606
2
GO_0000980 (EC: IDA, PMID:19861239); GO_0001076 (EC: IC, PMID:19861239); GO_0001077 (EC: IEA); GO_0001102 (EC: IPI, PMID:19861239); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003151 (EC: IEA); GO_0003682 (EC: IEA); GO_0003700 (EC: IDA, PMID:8798441); GO_0003705 (EC: IC, PMID:19861239); GO_0003713 (EC: TAS, PMID:2529117); GO_0004402 (EC: IDA, PMID:10821277); GO_0005515 (EC: IPI, PMID:10327051); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005741 (EC: IDA); GO_0006325 (EC: TAS); GO_0006355 (EC: IMP); GO_0006357 (EC: IC, PMID:19861239); GO_0006366 (EC: IC, PMID:19861239); GO_0006970 (EC: IDA); GO_0006974 (EC: IDA); GO_0006974 (EC: IMP, PMID:15916964); GO_0008140 (EC: IDA, PMID:19861239); GO_0016573 (EC: IDA, PMID:10821277); GO_0019901 (EC: IPI); GO_0031573 (EC: IMP, PMID:15916964); GO_0032915 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035497 (EC: IDA, PMID:19861239); GO_0035666 (EC: TAS); GO_0035861 (EC: IDA, PMID:15916964); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0045087 (EC: TAS); GO_0045444 (EC: IEA); GO_0046872 (EC: IEA); GO_0046982 (EC: IEA); GO_0051090 (EC: TAS); GO_0051091 (EC: IMP, PMID:10821277); GO_0051403 (EC: TAS); GO_0060612 (EC: IEA); GO_1902110 (EC: IMP)
PMID:602896; 1641004; 1827203; 1828107; 1833307; 1838349; 2320002; 2521922; 2529117; 7535770; 7737129; 7737130; 7769693; 7774816; 8027667; 8440710; 8628277; 8654373; 8798441; 9030721; 9058782; 9110174; 9139739; 9155018; 9162092; 9207092; 9207191; 9235954; 9399639; 9405416; 9445037; 9488727; 9524124; 9628874; 9659924; 9671405; 9685505; 9748258; 9786917; 9873047; 9920921; 10066798; 10085140; 10207054; 10327051; 10357819; 10393177; 10567391; 10708586; 10821277; 10878576; 10909971; 11231009; 11259586; 11279118; 11302752; 11564156; 11566021; 11713276; 11836564; 11839738; 11932306; 12110590; 12200150; 12244047; 12270648; 12477932; 12592382; 12663670; 12697749; 12761180; 12788955; 12804775; 12805554; 12833146; 12874243; 12958075; 14499342; 14630918; 14678960; 14734562; 14988408; 15105425; 15276183; 15302935; 15304344; 15546613; 15691875; 15692053; 15878807; 15916964; 16049073; 16179804; 16303757; 16344560; 16418168; 16456540; 16511568; 16533805; 16869889; 16896160; 17036053; 17054722; 17081983; 17082618; 17244683; 17254968; 17258390; 17296604; 17337306; 17626013; 17681939; 17869487; 17875713; 18029348; 18077426; 18307971; 18348191; 18396163; 18397884; 18547788; 18671972; 18677098; 18700251; 19082758; 19135240; 19176525; 19184334; 19278424; 19331149; 19453261; 19487697; 19712049; 19822663; 19861239; 19913121; 19923798; 19944700; 20051382; 20068037; 20116378; 20195357; 20211142; 20213747; 20379614; 20398657; 20498639; 20507983; 20581861; 20619956; 20628086; 20675274; 20956942; 21098032; 21203491; 21278380; 21384452; 21444723; 21565167; 21832049; 21858082; 21890473; 21901137; 21988832; 21990224; 22275354; 22304920; 22351776; 22439931; 22685333; 22843696; 23000965; 23589174; 23591579; 23656735; 23661758; 23966864; 24289970
activating transcription factor 2
Ensembl:ENSG00000115966
HGNC:784
HPRD:00443
MIM:123811
Vega:OTTHUMG00000132424
Other designations: activating transcription factor 2 splice variant ATF2-var2|cAMP response element-binding protein CRE-BP1|cAMP responsive element binding protein 2, formerly|cAMP-dependent transcription factor ATF-2|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-2|cyclic AMP-responsive element-binding protein 2|histone acetyltransferase ATF2
ATF2
Bin Zhao, Yue Liu, Oliver He
CREB-RP
CREBL1
G13
WEB: http://www.ncbi.nlm.nih.gov/gene
ATF6B
activating transcription factor 6 beta
1388
DADB-220I18.4
6p21.3
9606
6
GO_0003700 (EC: IEA); GO_0005515 (EC: IPI, PMID:12445808); GO_0005622 (EC: IDA, PMID:8870652); GO_0005634 (EC: IEA); GO_0005789 (EC: IEA); GO_0006351 (EC: IEA); GO_0006986 (EC: IEA); GO_0007165 (EC: TAS, PMID:8586413); GO_0016021 (EC: IEA); GO_0043565 (EC: IEA)
PMID:7686164; 8586413; 8870652; 8923003; 10644760; 11158310; 11163209; 11256944; 12445808; 12477932; 12782636; 14574404; 14656967; 14702039; 14973138; 18029348; 19693772; 19851445; 19913121; 20628086; 21139048; 21693764; 22094256; 23535732; 23577725; 23661758; 23886662; 24250222
activating transcription factor 6 beta
Ensembl:ENSG00000213676
HGNC:2349
HPRD:02992
MIM:600984
Vega:OTTHUMG00000031296
Other designations: Creb-related protein|cAMP response element-binding protein-related protein|cAMP responsive element binding protein-like 1|cAMP-dependent transcription factor ATF-6 beta|cAMP-responsive element-binding protein-like 1|cyclic AMP-dependent transcription factor ATF-6 beta|protein G13
ATF6B
Bin Zhao, Yue Liu, Oliver He
PTX1
WEB: http://www.ncbi.nlm.nih.gov/gene
CRP
C-reactive protein, pentraxin-related
1401
RP11-419N10.4
1q23.2
9606
1
Official from a nomenclature committee
GO_0001666 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17785206); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005615 (EC: IEA); GO_0006953 (EC: TAS, PMID: 2477488); GO_0006954 (EC: TAS, PMID: 10408362); GO_0006958 (EC: IEA); GO_0007568 (EC: IEA); GO_0008228 (EC: TAS, PMID: 2477488); GO_0010288 (EC: IEA); GO_0010745 (EC: IDA, PMID: 18322245); GO_0010888 (EC: IDA, PMID: 18322245); GO_0015485 (EC: IEA); GO_0030169 (EC: IDA, PMID: 18322245); GO_0030175 (EC: IEA); GO_0030426 (EC: IEA); GO_0033265 (EC: TAS, PMID: 2477488); GO_0042060 (EC: IEA); GO_0042803 (EC: IEA); GO_0045471 (EC: IEA); GO_0046872 (EC: IEA); GO_0050830 (EC: TAS, PMID: 2477488); GO_0051258 (EC: IEA); GO_0071277 (EC: IEA); GO_1900006 (EC: IEA)
PMID: 265538; 403526; 762075; 1477104; 1989977; 2477447; 2477488; 2997165; 3759147; 3840479; 6427230; 6685157; 6693419; 6857266; 7881902; 8144569; 8482924; 8599761; 8613143; 10368284; 10408362; 10490997; 10675363; 11027634; 11739301; 11801683; 11857055; 11947917; 11964845; 11991668; 12033985; 12037301; 12055255; 12102655; 12104096; 12151853; 12186793; 12198121; 12213988; 12218140; 12234944; 12244213; 12351483; 12390313; 12393563; 12426217; 12426218; 12460042; 12471137; 12477932; 12529491; 12552583; 12563060; 12594844; 12616974; 12618085; 12637157; 12654086; 12663465; 12701054; 12716818; 12783932; 12819031; 12821545; 12835213; 12835218; 12842840; 12850811; 12869354; 12892901; 12934049; 12975260; 14500938; 14506615; 14508181; 14592848; 14634117; 14718574; 14744975; 14967730; 14967837; 14983228; 15044210; 15047644; 15078802; 15136507; 15271790; 15277326; 15286457; 15304023; 15306744; 15308783; 15337754; 15358216; 15380464; 15448085; 15456743; 15469865; 15472120; 15489334; 15517131; 15565375; 15579759; 15585208; 15585211; 15585215; 15585218; 15591095; 15653107; 15692104; 15735209; 15746456; 15766555; 15772777; 15777561; 15778807; 15795363; 15797975; 15798948; 15798966; 15808312; 15853546; 15859024; 15860734; 15866055; 15867284; 15878871; 15887860; 15894122; 15894827; 15897982; 15919817; 15920036; 15920065; 15920074; 15950309; 15955385; 15955391; 15993896; 15996056; 15997206; 16005364; 16005367; 16026589; 16051899; 16061741; 16087790; 16087807; 16109328; 16123325; 16131811; 16148535; 16151032; 16153429; 16170833; 16189249; 16213874; 16221209; 16257408; 16266402; 16306468; 16344720; 16352308; 16380821; 16405882; 16409458; 16417933; 16500582; 16501036; 16511556; 16534007; 16549465; 16550411; 16565153; 16580524; 16582918; 16603696; 16618976; 16643876; 16681424; 16682383; 16685271; 16698114; 16710414; 16719793; 16723442; 16731635; 16733231; 16751408; 16764962; 16765355; 16778366; 16803998; 16809555; 16809564; 16832147; 16832152; 16840032; 16847147; 16854501; 16858645; 16864904; 16879213; 16881737; 16908949; 16916777; 16963054; 16984505; 17003778; 17011566; 17044846; 17079491; 17082472; 17101857; 17110595; 17113035; 17113059; 17114654; 17126343; 17138933; 17141244; 17143564; 17148079; 17149558; 17157301; 17164456; 17185152; 17202380; 17211240; 17219082; 17220790; 17234298; 17261875; 17264952; 17279354; 17289011; 17292342; 17293598; 17325687; 17327459; 17335789; 17335903; 17343862; 17347578; 17350021; 17351284; 17355554; 17355643; 17369452; 17372148; 17380191; 17382928; 17383146; 17395501; 17400881; 17433639; 17449131; 17449922; 17452737; 17456635; 17459567; 17460724; 17477779; 17477815; 17498578; 17499233; 17511977; 17513778; 17519779; 17530289; 17531242; 17561469; 17573060; 17575367; 17581635; 17584642; 17588586; 17596285; 17597836; 17598370; 17600233; 17613401; 17615382; 17623721; 17623828; 17635239; 17641153; 17650829; 17652082; 17652155; 17653654; 17673235; 17676666; 17693973; 17697822; 17700210; 17702862; 17702963; 17706955; 17714716; 17714718; 17722225; 17763921; 17765290; 17785206; 17785926; 17806085; 17827818; 17845537; 17851127; 17851695; 17852082; 17852826; 17873311; 17878721; 17878753; 17880812; 17885262; 17888441; 17891599; 17900590; 17903293; 17909163; 17917609; 17920229; 17925606; 17934713; 17942113; 17943468; 17952446; 17956875; 17957146; 17981284; 17991470; 18000615; 18005189; 18023360; 18036188; 18054331; 18055473; 18055714; 18056120; 18060926; 18063701; 18071779; 18075240; 18078625; 18083122; 18096828; 18165866; 18167554; 18171282; 18172744; 18178503; 18182444; 18200582; 18206145; 18214695; 18216376; 18217154; 18218989; 18219371; 18219765; 18226363; 18226879; 18235049; 18241613; 18245530; 18250134; 18262272; 18263601; 18266777; 18279706; 18280482; 18285551; 18285696; 18288276; 18289549; 18296838; 18297417; 18305316; 18312679; 18316365; 18322245; 18327405; 18328265; 18332893; 18333373; 18344622; 18347271; 18347963; 18356846; 18359028; 18362454; 18365276; 18369665; 18372435; 18373721; 18378435; 18379563; 18383516; 18385179; 18385676; 18385743; 18385816; 18386294; 18388036; 18388037; 18389332; 18393253; 18394761; 18401567; 18403728; 18404970; 18412163; 18413218; 18414778; 18415802; 18418236; 18421029; 18422436; 18425592; 18428198; 18433460; 18436879; 18436884; 18439548; 18439552; 18443549; 18450770; 18458051; 18464913; 18476570; 18486609; 18489822; 18491455; 18493116; 18499652; 18500540; 18505467; 18508060; 18513241; 18513823; 18523031; 18541797; 18551710; 18556380; 18562472; 18566104; 18573122; 18573197; 18573495; 18577830; 18591402; 18605934; 18607165; 18609082; 18609102; 18616717; 18621860; 18622582; 18624398; 18632424; 18636307; 18650775; 18654020; 18654021; 18667998; 18675273; 18676680; 18685607; 18688084; 18695743; 18700811; 18702945; 18704199; 18704713; 18708524; 18710885; 18714381; 18714384; 18753723; 18753952; 18755462; 18757054; 18759279; 18764931; 18784972; 18785307; 18786923; 18790479; 18791482; 18793001; 18801352; 18805107; 18805592; 18810599; 18810717; 18818748; 18823889; 18829218; 18835219; 18836266; 18840622; 18841009; 18842294; 18842390; 18845301; 18852001; 18853099; 18853133; 18924263; 18937150; 18948966; 18952164; 18953261; 18957790; 18971492; 18974842; 18983663; 18996288; 18997194; 19004040; 19008293; 19010993; 19011614; 19019335; 19023151; 19025443; 19026696; 19029268; 19034331; 19040303; 19055599; 19060910; 19067532; 19072030; 19073362; 19074515; 19074985; 19075099; 19076828; 19077177; 19077918; 19078972; 19081678; 19084272; 19095725; 19096002; 19100387; 19101671; 19111610; 19117239; 19118119; 19122170; 19125286; 19128923; 19130414; 19136614; 19136826; 19138871; 19139603; 19139754; 19147740; 19155486; 19160050; 19168253; 19170196; 19170684; 19172699; 19178964; 19179966; 19188531; 19191811; 19193941; 19201044; 19201207; 19202332; 19203753; 19225207; 19228486; 19238141; 19240794; 19244088; 19248087; 19251259; 19252093; 19255512; 19262552; 19267250; 19267370; 19268605; 19268941; 19270348; 19272152; 19276622; 19281089; 19282426; 19282606; 19282863; 19297430; 19297456; 19322079; 19323703; 19328934; 19337791; 19343415; 19351632; 19358836; 19359657; 19360108; 19362308; 19369869; 19375128; 19377212; 19377253; 19387251; 19390179; 19394732; 19403254; 19410251; 19415164; 19415283; 19423540; 19426506; 19428053; 19433520; 19436122; 19436291; 19436676; 19436686; 19437230; 19439300; 19439303; 19461040; 19469014; 19473152; 19480860; 19482283; 19492468; 19494488; 19495883; 19499327; 19501581; 19501644; 19520972; 19521085; 19522741; 19523464; 19525580; 19527514; 19533498; 19534672; 19538326; 19545442; 19560102; 19565490; 19567438; 19568166; 19571581; 19576194; 19577754; 19578796; 19584180; 19594772; 19595394; 19602903; 19609738; 19614793; 19615354; 19617288; 19619902; 19620133; 19624831; 19625176; 19626399; 19631649; 19642908; 19643839; 19643942; 19644070; 19645035; 19667982; 19670170; 19680263; 19692124; 19692168; 19695857; 19706826; 19715516; 19719987; 19719993; 19728551; 19729797; 19736474; 19736479; 19751919; 19755616; 19760027; 19762396; 19762397; 19766699; 19783155; 19796676; 19800416; 19801321; 19806245; 19808368; 19816865; 19816870; 19818961; 19821022; 19833744; 19834334; 19850242; 19850925; 19851048; 19853918; 19855269; 19857655; 19857676; 19864399; 19874580; 19879773; 19900432; 19903811; 19906786; 19913121; 19914996; 19923014; 19929715; 19931932; 19942863; 19944144; 19946607; 19947988; 19948975; 19954777; 19956729; 19962488; 19965533; 20004425; 20005739; 20006362; 20017311; 20024640; 20031768; 20034371; 20036017; 20042240; 20047081; 20056225; 20056955; 20060752; 20068351; 20074254; 20075180; 20075509; 20075574; 20078870; 20078877; 20083961; 20131075; 20136960; 20138378; 20142117; 20145391; 20145925; 20170291; 20173307; 20179497; 20184510; 20184533; 20184536; 20186934; 20190687; 20200626; 20200627; 20211068; 20214668; 20215002; 20219150; 20220110; 20227257; 20227921; 20233980; 20237496; 20306065; 20333461; 20339115; 20339904; 20346360; 20346514; 20348053; 20359087; 20371432; 20386340; 20403997; 20406964; 20423474; 20423919; 20437055; 20438785; 20443669; 20453000; 20453690; 20465852; 20466978; 20485444; 20489166; 20494358; 20494378; 20502295; 20511616; 20522534; 20531240; 20537668; 20538124; 20538278; 20538960; 20539018; 20546810; 20552244; 20556836; 20573938; 20581772; 20587599; 20592333; 20596037; 20596713; 20599197; 20605213; 20610232; 20614004; 20618287; 20623261; 20626020; 20626239; 20626701; 20628086; 20638228; 20640440; 20651278; 20669343; 20670634; 20676960; 20679960; 20680929; 20683147; 20686879; 20690093; 20691829; 20703235; 20704541; 20706769; 20709501; 20722986; 20727736; 20730440; 20733302; 20734449; 20797493; 20805569; 20813565; 20819268; 20836727; 20843812; 20846522; 20846939; 20850446; 20852043; 20855282; 20855565; 20856253; 20874781; 20877716; 20881941; 20883364; 20929576; 20929699; 20930309; 20939118; 20949557; 20952358; 20967757; 20972697; 20974458; 20978825; 20979755; 21029360; 21029457; 21033124; 21034294; 21037097; 21037509; 21043803; 21044752; 21044781; 21054666; 21054877; 21059738; 21062467; 21067752; 21071964; 21080913; 21081932; 21086905; 21089116; 21094359; 21105323; 21108561; 21135979; 21136015; 21143859; 21143879; 21146168; 21149504; 21161711; 21162890; 21167068; 21172733; 21173097; 21173540; 21182750; 21190868; 21194909; 21195701; 21196492; 21203342; 21204606; 21215477; 21218608; 21226995; 21258804; 21270838; 21284020; 21287288; 21293934; 21294915; 21296145; 21296900; 21300955; 21305296; 21309051; 21309632; 21315565; 21323571; 21324310; 21325005; 21325757; 21357282; 21357824; 21360619; 21383176; 21402418; 21404895; 21406102; 21413847; 21414621; 21415385; 21444086; 21447704; 21455669; 21458205; 21465964; 21468168; 21476028; 21493089; 21508123; 21516340; 21519150; 21526633; 21536287; 21546857; 21553357; 21565862; 21570260; 21575917; 21592994; 21602602; 21617097; 21624120; 21625240; 21630214; 21640994; 21645137; 21647738; 21655904; 21658317; 21679689; 21685272; 21696613; 21697747; 21700090; 21714897; 21716910; 21719129; 21720757; 21729568; 21729973; 21730823; 21737650; 21740772; 21741099; 21757662; 21773944; 21794939; 21801245; 21804277; 21814873; 21816845; 21819975; 21821037; 21831326; 21832113; 21839826; 21843630; 21845926; 21856781; 21859817; 21868617; 21872279; 21883780; 21890096; 21901123; 21915265; 21923250; 21928234; 21931794; 21933586; 21934067; 21937998; 21951717; 21958326; 21970447; 21988832; 21993388; 22004660; 22014839; 22018511; 22019947; 22019953; 22025173; 22025360; 22038335; 22048011; 22055258; 22056216; 22079264; 22082888; 22095223; 22103876; 22104116; 22119118; 22134501; 22153152; 22158621; 22166506; 22178353; 22190020; 22192441; 22196954; 22203929; 22205174; 22208681; 22222005; 22241816; 22257305; 22260948; 22267327; 22267750; 22267767; 22277294; 22284830; 22291609; 22296194; 22297435; 22306563; 22311704; 22316266; 22316276; 22328138; 22329434; 22330622; 22357713; 22365588; 22392590; 22418747; 22418989; 22428468; 22430136; 22435454; 22437883; 22444955; 22446726; 22449109; 22457095; 22459389; 22464286; 22467322; 22474034; 22490475; 22492993; 22497530; 22529527; 22533665; 22545649; 22547903; 22552174; 22554299; 22556030; 22558327; 22562290; 22569431; 22569435; 22570140; 22576068; 22580582; 22588996; 22607374; 22614460; 22617158; 22641545; 22642594; 22645408; 22672862; 22676422; 22681496; 22683644; 22685243; 22685586; 22732721; 22748017; 22750226; 22763479; 22780440; 22783580; 22783989; 22796263; 22801596; 22813435; 22813921; 22816656; 22821639; 22828776; 22832641; 22836155; 22843654; 22847196; 22857740; 22867744; 22869540; 22875408; 22875596; 22884413; 22901456; 22906275; 22906998; 22911253; 22912790; 22914173; 22918393; 22939635; 22949303; 22957001; 22976070; 22982460; 22989605; 23013513; 23026925; 23046580; 23049543; 23066418; 23078984; 23087143; 23087294; 23104422; 23111890; 23116190; 23116196; 23124693; 23125484; 23126320; 23132698; 23139417; 23151748; 23158132; 23159256; 23166385; 23170819; 23182717; 23197238; 23197841; 23206444; 23212397; 23212764; 23220502; 23221172; 23224322; 23225486; 23228375; 23241067; 23254637; 23254959; 23257175; 23257395; 23263911; 23266263; 23270673; 23272049; 23274882; 23277135; 23285029; 23288467; 23306163; 23343124; 23361365; 23367494; 23375121; 23375154; 23379491; 23383155; 23393371; 23399387; 23401350; 23409097; 23425215; 23434327; 23440541; 23450030; 23463453; 23468212; 23484158; 23492986; 23516493; 23518675; 23527487; 23535585; 23547018; 23575330; 23576062; 23578742; 23579782; 23591413; 23592000; 23604041; 23618082; 23627410; 23635436; 23674518; 23692330; 23697277; 23702388; 23724031; 23724977; 23742758; 23766379; 23773138; 23784529; 23803251; 23808014; 23813138; 23813850; 23828261; 23835994; 23844046; 23852903; 23888317; 23910616; 23911413; 23935961; 23941472; 23968978; 24055729; 24072695; 24084772; 24097561; 24163955; 24206243; 24222149; 24222151; 24262327; 24347428; 24379064; 24403485; 24434384; 24440351
C-reactive protein, pentraxin-related
Ensembl:ENSG00000132693
HGNC:2367
HPRD:00422
MIM:123260
Vega:OTTHUMG00000035344
Other designations: C-reactive protein|pentraxin 1
CRP
Bin Zhao, Yue Liu, Oliver He
APPS
CPSB
WEB: http://www.ncbi.nlm.nih.gov/gene
CTSB
cathepsin B
1508
8p22
20140408
9606
8
protein-coding
Official from a nomenclature committee
GO_0002224 (EC: TAS); GO_0004197 (EC: IDA); GO_0005515 (EC: IPI, PMID: 16364318); GO_0005518 (EC: IDA); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005615 (EC: ISS); GO_0005622 (EC: TAS, PMID: 1645961); GO_0005730 (EC: IDA); GO_0005739 (EC: IEA); GO_0005764 (EC: IDA, PMID: 1837142); GO_0006508 (EC: IDA, PMID: 7890620); GO_0008233 (EC: IDA, PMID: 7890620); GO_0008234 (EC: IDA, PMID: 8811434); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030574 (EC: IDA); GO_0030574 (EC: TAS); GO_0030855 (EC: IEP); GO_0036021 (EC: TAS); GO_0042470 (EC: IEA); GO_0042981 (EC: TAS, PMID: 16130169); GO_0043231 (EC: IDA); GO_0043394 (EC: IPI); GO_0045087 (EC: TAS); GO_0048471 (EC: IDA, PMID: 15614436); GO_0050790 (EC: IEA); GO_0051603 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19199708); GO_0097067 (EC: IEP)
PMID: 417724; 1326552; 1577456; 1597471; 1637335; 1645961; 1837142; 1868826; 1900515; 1984484; 1996959; 2061332; 2476070; 3010323; 3463996; 3542996; 3972105; 6203523; 6351842; 7509303; 7622042; 7718586; 7890620; 8014475; 8083219; 8112600; 8617355; 8635854; 8811434; 9076588; 9295331; 9299326; 9360997; 9412840; 9539769; 9582368; 9585570; 9632704; 9733783; 9770500; 9776083; 9928950; 10353845; 10395917; 10512713; 10777578; 10849756; 10876156; 11016923; 11115496; 11134363; 11139332; 11162551; 11228542; 11241311; 11435427; 11513559; 11514663; 11536009; 11746262; 11815600; 11932257; 12057992; 12072442; 12086583; 12102727; 12185082; 12186841; 12189154; 12201820; 12437117; 12437120; 12477932; 12581740; 12589965; 12643545; 12677446; 12726991; 12887051; 12893746; 12926111; 14503883; 14702039; 14729603; 14730346; 14984956; 15016552; 15100281; 15122332; 15231747; 15255544; 15262981; 15274632; 15489334; 15512772; 15614436; 15679122; 15710602; 15799821; 15807897; 15816632; 15831716; 15832773; 16034129; 16051222; 16077201; 16130169; 16169070; 16303743; 16315320; 16364318; 16381007; 16492714; 16534247; 16709808; 16733801; 16894574; 16913838; 16914553; 17064696; 17081065; 17504810; 17507477; 17519890; 17724614; 17726009; 17982689; 17990360; 17991740; 18029348; 18163891; 18296264; 18314113; 18472965; 18515357; 18543249; 18566385; 18566436; 18598236; 18616803; 18706099; 18714186; 18718938; 18760860; 18949742; 19004543; 19040356; 19199708; 19331819; 19414800; 19434518; 19454696; 19615732; 19661440; 19692168; 19700239; 19774387; 19811804; 19913121; 19915865; 19930869; 20008285; 20042316; 20180636; 20302512; 20424577; 20536394; 20563251; 20567828; 20584670; 20627011; 20628086; 20661471; 20699092; 20706999; 20833970; 20880494; 20930303; 21060833; 21092200; 21112096; 21139048; 21199580; 21250859; 21323990; 21508263; 21541353; 21562164; 21585286; 21600167; 21742978; 21832049; 21835790; 21840777; 21850018; 21880013; 21890473; 21900206; 21925292; 21945151; 21948970; 21967108; 22066471; 22118674; 22127599; 22138708; 22190034; 22209964; 22222211; 22262857; 22266111; 22268729; 22278224; 22287159; 22322590; 22384200; 22464443; 22467319; 22571763; 22693552; 22695494; 22732093; 22745374; 22782900; 22851129; 22939629; 22949512; 23024364; 23063511; 23189279; 23195957; 23219593; 23222509; 23222817; 23292187; 23349634; 23362198; 23466190; 23591598; 23602568; 23603447; 23633927; 23667900; 23677785; 23708264; 23867824
cathepsin B
Ensembl:ENSG00000164733
HGNC:2527
HPRD:00287
MIM:116810
Vega:OTTHUMG00000090799
Other designations: APP secretase|amyloid precursor protein secretase|cathepsin B1|cysteine protease
CTSB
Bin Zhao, Yue Liu, Oliver He
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
1543
15q24.1
9606
15
GO_0001666 (EC: IEA); GO_0005506 (EC: IEA); GO_0005739 (EC: IEA); GO_0005789 (EC: TAS); GO_0006778 (EC: IEA); GO_0006805 (EC: TAS); GO_0007568 (EC: IEA); GO_0008283 (EC: IEA); GO_0008395 (EC: IEA); GO_0009308 (EC: IEA); GO_0009611 (EC: IEA); GO_0009615 (EC: IEA); GO_0009624 (EC: IEA); GO_0009635 (EC: IEA); GO_0009792 (EC: IEA); GO_0009804 (EC: IEA); GO_0009812 (EC: IEA); GO_0010041 (EC: IEA); GO_0014070 (EC: IEA); GO_0016491 (EC: IDA, PMID:19219744); GO_0016679 (EC: IEA); GO_0016711 (EC: IEA); GO_0017143 (EC: IEA); GO_0017144 (EC: IDA, PMID:19219744); GO_0019341 (EC: IEA); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0019825 (EC: TAS, PMID:1691986); GO_0019899 (EC: IEA); GO_0020037 (EC: IEA); GO_0032094 (EC: IEA); GO_0032451 (EC: IEA); GO_0032496 (EC: IEA); GO_0033189 (EC: IEA); GO_0042359 (EC: IC, PMID:15546903); GO_0042493 (EC: IEA); GO_0042904 (EC: IEA); GO_0043010 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0046677 (EC: IEA); GO_0046685 (EC: IEA); GO_0048565 (EC: IEA); GO_0050665 (EC: IEA); GO_0055093 (EC: IEA); GO_0055114 (EC: IDA, PMID:19219744); GO_0060137 (EC: IEA); GO_0070330 (EC: IEA); GO_0070365 (EC: IEA); GO_0070576 (EC: IDA, PMID:15546903); GO_0097267 (EC: TAS); GO_1900087 (EC: IEA)
PMID:1691986; 1722803; 1761516; 2989797; 3000715; 3019683; 3714481; 3838385; 4000952; 6102994; 8095225; 8125298; 8313840; 8442765; 8548778; 8895751; 9500998; 9890157; 10493257; 10612842; 10739168; 11037802; 11037803; 11045797; 11052546; 11124296; 11159735; 11162685; 11172643; 11191882; 11207026; 11236859; 11246217; 11259393; 11275366; 11279306; 11291049; 11295132; 11295847; 11325850; 11330960; 11389067; 11393538; 11396202; 11406420; 11406608; 11408349; 11408954; 11410321; 11418090; 11422615; 11434510; 11436564; 11459424; 11470760; 11470992; 11470996; 11471167; 11484167; 11485833; 11487538; 11488937; 11500195; 11501853; 11503278; 11507974; 11511301; 11520401; 11525595; 11535253; 11551408; 11564581; 11641039; 11675150; 11675474; 11689007; 11698341; 11719088; 11751440; 11752233; 11779261; 11792676; 11793160; 11798822; 11833070; 11854392; 11859435; 11860825; 11860900; 11872636; 11895912; 11934439; 11952781; 11955671; 11967624; 11996959; 12018173; 12030651; 12034316; 12036913; 12063626; 12071517; 12100112; 12110344; 12139735; 12144816; 12147246; 12163326; 12170467; 12171760; 12175533; 12183419; 12189551; 12210502; 12210751; 12237110; 12269988; 12297440; 12351530; 12354067; 12365037; 12378791; 12397416; 12419832; 12435115; 12464257; 12468438; 12477932; 12484238; 12490585; 12496044; 12527337; 12548461; 12569554; 12574216; 12579334; 12590982; 12594823; 12602902; 12620480; 12631667; 12646505; 12670526; 12680328; 12690010; 12713578; 12718576; 12729704; 12732844; 12738724; 12746631; 12748560; 12760253; 12767509; 12767526; 12771031; 12772461; 12777964; 12824892; 12827651; 12845676; 12846365; 12854128; 12879168; 12880680; 12883749; 12903034; 12919721; 12925969; 12934333; 12949934; 14510941; 14534704; 14560034; 14582397; 14602139; 14602525; 14611903; 14634838; 14639127; 14646291; 14656945; 14665706; 14675315; 14687717; 14693745; 14695173; 14719475; 14724908; 14734460; 14758730; 14991750; 15013696; 15037607; 15039299; 15052670; 15059326; 15061915; 15064998; 15069692; 15088300; 15093273; 15111988; 15124938; 15127181; 15127559; 15128046; 15136237; 15152552; 15176217; 15177667; 15180167; 15184245; 15185560; 15194533; 15195126; 15206494; 15215328; 15217514; 15241822; 15279831; 15298956; 15298960; 15299091; 15319333; 15327835; 15333250; 15333597; 15341023; 15352038; 15355699; 15363546; 15375499; 15376230; 15381379; 15382051; 15382273; 15386428; 15459023; 15469410; 15478298; 15489334; 15491310; 15496536; 15521013; 15526353; 15528152; 15546903; 15547760; 15552037; 15579657; 15583370; 15591802; 15596250; 15605089; 15618738; 15640066; 15642161; 15643613; 15646021; 15647817; 15648054; 15653213; 15671210; 15712341; 15725614; 15731166; 15734083; 15734958; 15756908; 15764294; 15765281; 15769360; 15774541; 15774926; 15801491; 15849806; 15856430; 15861041; 15867368; 15870154; 15914211; 15914277; 15920291; 15928955; 15931768; 15938845; 15941966; 15952134; 15953982; 15981231; 15986113; 15991278; 16009381; 16012082; 16037119; 16043197; 16051642; 16084889; 16099114; 16103451; 16130011; 16142442; 16153604; 16202920; 16227674; 16228113; 16235998; 16254684; 16260521; 16270381; 16273625; 16284375; 16284498; 16318816; 16319265; 16337337; 16357593; 16357600; 16360200; 16367916; 16393248; 16402077; 16402549; 16403567; 16407087; 16414014; 16416283; 16424825; 16426572; 16466991; 16471212; 16481407; 16484137; 16488179; 16492926; 16493615; 16505155; 16527884; 16580705; 16598069; 16599372; 16608396; 16609368; 16614107; 16614120; 16620591; 16625286; 16638864; 16676594; 16697254; 16721740; 16763966; 16767678; 16771603; 16788090; 16792888; 16803538; 16807674; 16823842; 16834659; 16835796; 16837240; 16864595; 16882880; 16914185; 16926176; 16947004; 16949388; 16956909; 16971197; 16977255; 16985026; 16985033; 16985250; 16998606; 17022435; 17035385; 17053541; 17063266; 17078101; 17081983; 17083362; 17113562; 17118447; 17119063; 17158763; 17160265; 17160896; 17164366; 17167268; 17171211; 17174438; 17191090; 17192049; 17220347; 17307802; 17307803; 17311112; 17316563; 17361553; 17363580; 17367411; 17372239; 17372243; 17372252; 17403528; 17408703; 17412371; 17427032; 17428572; 17429172; 17429315; 17449539; 17461521; 17477782; 17479406; 17496311; 17498780; 17507624; 17512722; 17512776; 17526865; 17531965; 17548691; 17549424; 17566695; 17577786; 17588204; 17589376; 17590289; 17603290; 17610937; 17611777; 17620151; 17623765; 17630984; 17640999; 17642299; 17646057; 17651397; 17695473; 17706398; 17711714; 17717632; 17728147; 17786624; 17823232; 17852022; 17873299; 17896209; 17900751; 17908297; 17919073; 17919675; 17959138; 17980001; 17980933; 17981384; 17982751; 17996038; 18061941; 18065768; 18070799; 18074679; 18078203; 18082227; 18090121; 18159984; 18180754; 18200441; 18203021; 18203634; 18224491; 18241825; 18247309; 18261353; 18268125; 18285692; 18287863; 18287869; 18304461; 18317771; 18318428; 18320229; 18339256; 18351133; 18389617; 18409146; 18409147; 18414197; 18415690; 18415801; 18437510; 18447907; 18449058; 18463401; 18493746; 18495522; 18496222; 18497059; 18507050; 18507060; 18510611; 18550589; 18569591; 18577398; 18589596; 18590468; 18593984; 18601742; 18618215; 18628428; 18632753; 18636124; 18642288; 18676680; 18691756; 18698632; 18700132; 18706519; 18763031; 18767181; 18768509; 18774560; 18779756; 18784359; 18798002; 18800292; 18818748; 18819424; 18824009; 18849443; 18936436; 18941913; 18979064; 18980759; 18990008; 18990750; 18992263; 19009239; 19012698; 19013013; 19019335; 19022366; 19024313; 19031960; 19064581; 19070657; 19074885; 19110417; 19126602; 19127255; 19138996; 19143007; 19147266; 19160101; 19170196; 19174490; 19178087; 19219744; 19222528; 19229255; 19246429; 19252926; 19264525; 19267064; 19276377; 19285097; 19287966; 19290787; 19303595; 19307236; 19317600; 19336370; 19338043; 19339270; 19343046; 19346634; 19351467; 19356113; 19387820; 19412423; 19414505; 19415745; 19424633; 19424794; 19427967; 19430483; 19443378; 19452301; 19453261; 19456854; 19469619; 19472123; 19479063; 19505920; 19507017; 19507064; 19521675; 19526463; 19527514; 19537956; 19538838; 19561157; 19563927; 19574343; 19575027; 19576320; 19582785; 19598235; 19608585; 19625176; 19627379; 19630952; 19632247; 19639480; 19643819; 19650794; 19666078; 19679043; 19682433; 19692168; 19718946; 19750329; 19751749; 19776291; 19786002; 19789190; 19789301; 19797843; 19799358; 19822571; 19826048; 19827888; 19860743; 19863350; 19892789; 19899130; 19903800; 19913121; 19947517; 19948975; 19954068; 19954069; 19963114; 19963139; 19995559; 20009880; 20012094; 20027111; 20029944; 20032816; 20035380; 20047124; 20052535; 20054510; 20080081; 20088379; 20088394; 20094781; 20095411; 20131310; 20136364; 20177288; 20193595; 20214802; 20226777; 20297661; 20345875; 20373852; 20375710; 20377136; 20381444; 20428802; 20437850; 20453000; 20462615; 20491576; 20511665; 20529763; 20534171; 20544687; 20554493; 20559649; 20579990; 20584197; 20596254; 20602615; 20628086; 20628863; 20634197; 20634891; 20638923; 20644561; 20661821; 20664892; 20700368; 20701904; 20704749; 20723587; 20734064; 20734807; 20804547; 20817259; 20845989; 20846153; 20850372; 20855412; 20878561; 20878621; 20883830; 20884258; 20886582; 20887941; 20937634; 20957336; 20962519; 20965504; 20970553; 21081473; 21086258; 21130723; 21211368; 21246002; 21254355; 21254556; 21262253; 21270613; 21304969; 21329749; 21357676; 21385088; 21402622; 21418988; 21438753; 21490707; 21508386; 21545198; 21545219; 21586621; 21590276; 21709011; 21710246; 21718208; 21775774; 21848428; 21859547; 21869479; 21870186; 21876539; 21909115; 21977969; 22000673; 22018952; 22025136; 22086975; 22088806; 22109568; 22154617; 22183307; 22213191; 22217397; 22236719; 22273851; 22277800; 22292665; 22294106; 22296350; 22297691; 22304463; 22311486; 22312901; 22359202; 22365406; 22374940; 22384629; 22392998; 22395499; 22422552; 22442665; 22448487; 22470100; 22579698; 22594779; 22611936; 22660220; 22664944; 22707145; 22733497; 22752755; 22754477; 22782580; 22837390; 22846179; 22847262; 22854411; 22855999; 22876118; 22893352; 22901117; 22909097; 22918668; 22948778; 22949628; 22951721; 22952673; 22964275; 22994769; 22997752; 23000097; 23013535; 23033491; 23046808; 23055196; 23056546; 23065259; 23065291; 23098461; 23111888; 23124075; 23152866; 23174221; 23178447; 23229202; 23259321; 23288144; 23293967; 23350368; 23353840; 23369756; 23381648; 23411129; 23419638; 23424205; 23471717; 23475304; 23492908; 23508959; 23528250; 23548414; 23619522; 23661361; 23707957; 23785672; 23816456; 23832578; 23840148; 23842721; 23860774; 23870476; 23886179; 23918309; 24091107; 24316127; 24355420
cytochrome P450, family 1, subfamily A, polypeptide 1
Ensembl:ENSG00000140465
HGNC:2595
HPRD:00148
MIM:108330
Vega:OTTHUMG00000142812
Other designations: CYPIA1|aryl hydrocarbon hydroxylase|cytochrome P1-450, dioxin-inducible|cytochrome P450 1A1|cytochrome P450 form 6|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1|cytochrome P450-C|cytochrome P450-P1|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
CYP1A1
Bin Zhao, Yue Liu, Oliver He
CP12
P3-450
P450(PA)
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
1544
15q24.1
9606
15
GO_0004497 (EC: IDA, PMID:15327587); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006706 (EC: IMP, PMID:18356043); GO_0006778 (EC: IEA); GO_0006805 (EC: TAS); GO_0009055 (EC: TAS, PMID:2813353); GO_0009403 (EC: IDA, PMID:11511187); GO_0009791 (EC: IEA); GO_0009820 (EC: IDA, PMID:11511187); GO_0010468 (EC: IEA); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:16401082); GO_0016712 (EC: IMP, PMID:2813353); GO_0017144 (EC: IDA, PMID:15327587); GO_0018894 (EC: IEA); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0019899 (EC: IPI, PMID:15680923); GO_0020037 (EC: IDA, PMID:17311915); GO_0030324 (EC: IEA); GO_0032259 (EC: TAS); GO_0032355 (EC: IEA); GO_0032451 (EC: IDA, PMID:2813353); GO_0032496 (EC: IEA); GO_0032787 (EC: IDA, PMID:19651758); GO_0034875 (EC: IDA, PMID:18619574); GO_0042737 (EC: IMP, PMID:18356043); GO_0042738 (EC: IDA, PMID:18619574); GO_0043231 (EC: IDA, PMID:2813353); GO_0044281 (EC: TAS); GO_0045333 (EC: IEA); GO_0046483 (EC: IDA, PMID:15327587); GO_0050665 (EC: IEA); GO_0055114 (EC: IDA, PMID:16401082); GO_0070330 (EC: IEA); GO_0070989 (EC: IDA, PMID:18619574); GO_0071276 (EC: IEA); GO_0071615 (EC: IDA, PMID:19029318); GO_0097267 (EC: TAS)
PMID:2575218; 2813353; 3000715; 3462722; 3517618; 3681487; 3755823; 8095225; 8287062; 8553685; 8573198; 8694864; 9398194; 9598815; 9797707; 9884316; 9890157; 10463577; 10493258; 10791558; 11153915; 11186132; 11207026; 11275366; 11393588; 11470995; 11496364; 11501059; 11507974; 11511187; 11749050; 11763009; 11782366; 11791895; 11817502; 11943609; 12067576; 12147246; 12181774; 12419832; 12445029; 12445035; 12477932; 12484238; 12534642; 12566081; 12569554; 12618594; 12630986; 12663508; 12692107; 12732846; 12790158; 12851801; 12900870; 12920202; 12925300; 12943470; 14563787; 14640293; 14648207; 14695651; 14714565; 14723376; 14976127; 15039299; 15110095; 15128046; 15241822; 15299091; 15319333; 15327587; 15349722; 15363478; 15382051; 15387446; 15466009; 15469410; 15489334; 15505641; 15519301; 15564895; 15643613; 15680923; 15734958; 15763632; 15770072; 15774926; 15849225; 15890241; 15901993; 15941966; 15949157; 15987714; 15996939; 16006997; 16048566; 16103451; 16130011; 16153396; 16157215; 16172230; 16188490; 16204462; 16307269; 16324277; 16385402; 16401082; 16402077; 16402549; 16406813; 16426572; 16471212; 16495781; 16505155; 16522833; 16538170; 16538176; 16609368; 16636061; 16740387; 16772608; 16775389; 16782969; 16800822; 16864595; 16882880; 16933202; 16969362; 16985026; 16985250; 17065585; 17164366; 17178267; 17191090; 17259654; 17295924; 17311915; 17345072; 17363580; 17370067; 17372239; 17418993; 17429315; 17477782; 17498780; 17503978; 17507615; 17507624; 17509724; 17564586; 17603224; 17603900; 17611010; 17615053; 17616786; 17627011; 17635176; 17688403; 17695473; 17823232; 17823234; 17852022; 17900275; 18052847; 18075470; 18077912; 18159984; 18180754; 18187423; 18200441; 18223460; 18231117; 18268115; 18318428; 18356043; 18389617; 18398030; 18455494; 18466106; 18490497; 18493746; 18496682; 18497059; 18499698; 18510611; 18544563; 18551037; 18569587; 18619574; 18628519; 18632753; 18690546; 18703023; 18751408; 18759349; 18784359; 18798002; 18801337; 18813311; 18825963; 18840375; 18850169; 18936436; 18941913; 18990750; 18992148; 18996102; 19000940; 19026171; 19029318; 19095219; 19106084; 19219744; 19229255; 19273964; 19274061; 19276377; 19285097; 19290787; 19307236; 19332078; 19336370; 19338043; 19339270; 19343046; 19356113; 19414633; 19415745; 19424794; 19430483; 19442564; 19450128; 19451835; 19452301; 19453261; 19479063; 19507017; 19534587; 19569730; 19571439; 19574343; 19575027; 19576320; 19583676; 19593158; 19593168; 19605743; 19636338; 19643819; 19651758; 19666078; 19682433; 19692168; 19751749; 19776291; 19789190; 19806921; 19822571; 19823875; 19843669; 19860743; 19913121; 19926050; 19956635; 19961320; 20029944; 20043572; 20047124; 20054636; 20080081; 20118554; 20125119; 20131310; 20136364; 20147896; 20163457; 20173083; 20175915; 20213484; 20214802; 20218903; 20304699; 20375710; 20381444; 20389299; 20390257; 20403997; 20437850; 20453000; 20505544; 20529763; 20559687; 20583967; 20602612; 20602615; 20628086; 20634197; 20634891; 20641098; 20652353; 20656072; 20663043; 20691427; 20701904; 20734064; 20797314; 20806393; 20829355; 20853468; 20881513; 20930417; 20933493; 20957336; 20970553; 21071160; 21072184; 21081473; 21086794; 21148426; 21210738; 21262253; 21281405; 21329464; 21357676; 21480221; 21490707; 21505853; 21598960; 21825116; 21876539; 21929532; 21977969; 22072123; 22086975; 22141270; 22228482; 22246422; 22258279; 22336631; 22426036; 22448362; 22466345; 22492992; 22628494; 22648710; 22673010; 22749033; 22785257; 22854411; 22855999; 22948892; 22949628; 23081704; 23128882; 23133610; 23138776; 23157985; 23167834; 23278694; 23292087; 23353840; 23492908; 23492909; 23601795; 23603339; 23628800; 23859573
cytochrome P450, family 1, subfamily A, polypeptide 2
Ensembl:ENSG00000140505
HGNC:2596
HPRD:00489
MIM:124060
Vega:OTTHUMG00000172901
Other designations: CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP1A2
Bin Zhao, Yue Liu, Oliver He
CP1B
CYPIB1
GLC3A
P4501B1
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
1545
2p22.2
9606
2
GO_0001525 (EC: IEA); GO_0004497 (EC: TAS, PMID:9097971); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006725 (EC: IEA); GO_0006805 (EC: IDA); GO_0006805 (EC: TAS); GO_0007601 (EC: TAS, PMID:9097971); GO_0008202 (EC: IDA); GO_0009404 (EC: IEA); GO_0009636 (EC: IEA); GO_0016125 (EC: TAS); GO_0016712 (EC: IDA, PMID:10871058); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0019825 (EC: TAS, PMID:9097971); GO_0020037 (EC: IDA); GO_0020037 (EC: TAS, PMID:9097971); GO_0043542 (EC: IEA); GO_0044281 (EC: TAS); GO_0055114 (EC: TAS, PMID:9097971); GO_0061298 (EC: IEA); GO_0070330 (EC: IEA); GO_0071603 (EC: IEA); GO_0097267 (EC: TAS)
PMID:1925598; 8175734; 8910454; 9097971; 9463332; 9497261; 9823305; 9890157; 10227395; 10614688; 10871058; 11221602; 11303589; 11389067; 11403040; 11452143; 11555828; 11558822; 11749050; 11774072; 11854439; 11955671; 12010864; 12183407; 12200121; 12372064; 12385014; 12415427; 12419832; 12477932; 12520071; 12525557; 12567107; 12598442; 12602902; 12618873; 12692107; 12718576; 12770747; 12807732; 12837283; 12844487; 12873984; 14507861; 14520706; 14562027; 14634838; 14656940; 14729846; 14734460; 14744739; 14961553; 15041720; 15072827; 15075793; 15102677; 15122594; 15128046; 15177664; 15199113; 15255109; 15255550; 15285606; 15297370; 15299091; 15333708; 15342454; 15342556; 15342693; 15382051; 15386537; 15475877; 15489334; 15596250; 15636228; 15654505; 15723004; 15733270; 15734954; 15734958; 15774541; 15777990; 15808404; 15861043; 15896461; 15905203; 15941966; 15958554; 15987428; 16006997; 16051642; 16103451; 16115918; 16172228; 16172230; 16202920; 16207128; 16260521; 16284375; 16319265; 16319821; 16344560; 16384942; 16490498; 16569655; 16598069; 16638984; 16688110; 16716118; 16730930; 16735991; 16735994; 16766147; 16808847; 16847423; 16850246; 16862072; 16864595; 16896040; 16949388; 16963504; 16977255; 16978616; 16985026; 16985250; 17035385; 17053044; 17063266; 17077994; 17157584; 17164573; 17174438; 17187946; 17200336; 17220347; 17224759; 17224914; 17301257; 17311112; 17321191; 17353931; 17363580; 17372239; 17372243; 17403528; 17429315; 17449539; 17449559; 17458695; 17496311; 17498780; 17507616; 17507624; 17548691; 17562158; 17563717; 17575219; 17588204; 17589376; 17591938; 17603900; 17615053; 17627011; 17642299; 17687619; 17704407; 17718864; 17893647; 17914928; 17919675; 17922187; 17925548; 17980933; 18055790; 18059014; 18067928; 18070520; 18187806; 18227148; 18258609; 18268125; 18318428; 18347981; 18385784; 18414103; 18415014; 18425393; 18470941; 18483560; 18486761; 18497059; 18510611; 18537981; 18544568; 18569579; 18569591; 18573508; 18575334; 18616618; 18622259; 18628428; 18632753; 18676680; 18763031; 18779756; 18784359; 18794456; 18820009; 18829176; 18841557; 18852424; 18922394; 18936436; 18977467; 18980759; 18989382; 18990750; 18992148; 19015200; 19031960; 19064581; 19074885; 19083124; 19094228; 19096718; 19116217; 19126602; 19127255; 19138946; 19138996; 19170196; 19174490; 19179758; 19195637; 19199255; 19208203; 19214745; 19229255; 19234632; 19247456; 19274671; 19287966; 19290787; 19293312; 19324859; 19331196; 19338043; 19343046; 19349377; 19357154; 19383894; 19414505; 19415745; 19424633; 19424794; 19443378; 19453261; 19479063; 19505920; 19514368; 19528825; 19536304; 19574343; 19575027; 19582785; 19597567; 19598235; 19622003; 19625176; 19630952; 19643970; 19666078; 19668563; 19668597; 19690133; 19692168; 19730035; 19736056; 19744731; 19751749; 19754948; 19776291; 19789190; 19789301; 19793111; 19820397; 19822571; 19857456; 19860743; 19895167; 19898482; 19908239; 19913121; 19956635; 19963139; 19995559; 20027111; 20029944; 20033481; 20037207; 20051892; 20054638; 20057908; 20088394; 20131310; 20137445; 20151268; 20184498; 20198857; 20198978; 20212917; 20214802; 20301314; 20357201; 20375710; 20391138; 20395011; 20403997; 20453000; 20461808; 20462226; 20492382; 20505544; 20529763; 20559649; 20568895; 20628086; 20632082; 20634197; 20634891; 20660114; 20664688; 20678202; 20683028; 20701755; 20734064; 20830506; 20845989; 20875115; 20878130; 20884258; 20887769; 21072184; 21081473; 21081970; 21139974; 21147782; 21168818; 21191305; 21303932; 21306220; 21409489; 21438753; 21458313; 21596299; 21600657; 21614911; 21655360; 21674184; 21683070; 21707071; 21742528; 21850185; 21854771; 21890473; 21963094; 21987572; 22004014; 22011756; 22114726; 22128238; 22138065; 22177211; 22190224; 22232929; 22272893; 22296381; 22327650; 22374940; 22459615; 22466345; 22504876; 22509109; 22594779; 22840970; 22859684; 22878448; 22942166; 23028769; 23032576; 23087145; 23215915; 23218183; 23218701; 23283740; 23325794; 23350153; 23350368; 23353840; 23370603; 23757320; 23785672; 23794133; 23861929; 23922489; 24227805
cytochrome P450, family 1, subfamily B, polypeptide 1
Ensembl:ENSG00000138061
HGNC:2597
HPRD:03464
MIM:601771
Vega:OTTHUMG00000100970
Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP1B1
Bin Zhao, Yue Liu, Oliver He
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
1548
19q13.2
9606
19
GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0005881 (EC: IDA); GO_0006805 (EC: TAS); GO_0008202 (EC: IMP, PMID:18356043); GO_0008389 (EC: IDA, PMID:16086027); GO_0009804 (EC: IDA, PMID:19651758); GO_0016712 (EC: IEA); GO_0017144 (EC: IDA, PMID:19651758); GO_0017144 (EC: IMP, PMID:18356043); GO_0019899 (EC: IPI, PMID:15680923); GO_0020037 (EC: IDA, PMID:16086027); GO_0042738 (EC: IDA, PMID:15680923); GO_0044281 (EC: TAS); GO_0046226 (EC: IDA, PMID:19029318)
PMID:1889415; 1944238; 2322567; 2726448; 2748347; 3856261; 4011450; 7581481; 7668294; 7864805; 8587134; 9409631; 9827545; 9890157; 10544257; 10781881; 11054771; 11207029; 11237731; 11241319; 11259349; 11278503; 11434509; 11684323; 11725533; 11805739; 11927498; 11927840; 11960911; 11960914; 12115524; 12162851; 12164325; 12172220; 12223434; 12325023; 12406643; 12419832; 12445030; 12477932; 12708602; 12721789; 12749606; 12844137; 12883749; 14568264; 14583682; 14981342; 15039299; 15128046; 15203795; 15225612; 15308589; 15327835; 15370155; 15454735; 15469410; 15475735; 15489334; 15534625; 15564629; 15592323; 15618701; 15660270; 15665333; 15671201; 15680923; 15861035; 15861044; 15900015; 15940289; 15993850; 16006997; 16041240; 16048566; 16086027; 16126166; 16176798; 16207711; 16272956; 16344560; 16372023; 16377082; 16378601; 16402086; 16402128; 16452582; 16470306; 16636685; 16720336; 16758265; 16857725; 16891249; 16952495; 17015050; 17036930; 17112802; 17130279; 17156750; 17207267; 17220563; 17259654; 17267622; 17454707; 17522595; 17540336; 17549345; 17646279; 17683511; 17916905; 17927692; 17934923; 17979512; 18004205; 18188752; 18212800; 18216723; 18356043; 18360915; 18380793; 18425152; 18510611; 18666753; 18698229; 18715882; 18936436; 18941913; 18976031; 18979093; 19012698; 19029318; 19040121; 19082995; 19104915; 19225447; 19251454; 19279561; 19290787; 19300303; 19303722; 19339270; 19343046; 19361454; 19365400; 19371316; 19387893; 19406142; 19415821; 19454817; 19479063; 19533856; 19537956; 19604090; 19643819; 19651758; 19659438; 19702528; 19703308; 19751749; 19779319; 19789190; 19845430; 19921195; 19956635; 20012030; 20061389; 20089352; 20136358; 20139165; 20155256; 20173083; 20177288; 20336063; 20418888; 20418890; 20437850; 20438369; 20506136; 20596643; 20647221; 20656072; 20701904; 20717551; 20719908; 20734048; 20734064; 20860463; 20887713; 21205058; 21265876; 21326246; 21410749; 21418183; 21473878; 21521021; 21685187; 21745589; 21747048; 21765098; 21791872; 21964962; 22073590; 22080838; 22160797; 22217675; 22271297; 22322240; 22342802; 22465937; 22497566; 22498344; 22547082; 22614024; 22696418; 22706231; 22847926; 22854688; 22890016; 23049750; 23178447; 23203414; 23292114; 23371292; 23462429; 23471717; 23528144; 23585826; 23649654; 23733493; 23813797
cytochrome P450, family 2, subfamily A, polypeptide 6
Ensembl:ENSG00000255974
HGNC:2610
HPRD:00420
MIM:122720
Vega:OTTHUMG00000182713
Other designations: 1,4-cineole 2-exo-monooxygenase|coumarin 7-hydroxylase|cytochrome P450 2A6|cytochrome P450 IIA3|cytochrome P450(I)|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
CYP2A6
Bin Zhao, Yue Liu, Oliver He
CPA7
CPAD
CYP2A
CYPIIA7
P450-IIA4
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
1549
19q13.2
9606
19
GO_0005506 (EC: IEA); GO_0005789 (EC: IEA); GO_0019825 (EC: TAS, PMID:7864805); GO_0020037 (EC: IEA); GO_0070330 (EC: IEA)
PMID:2322567; 7668294; 7864805; 8043031; 8587134; 9890157; 10353262; 10493259; 11960914; 12325023; 12477932; 15128046; 16636685; 22890016
cytochrome P450, family 2, subfamily A, polypeptide 7
Ensembl:ENSG00000198077
HGNC:2611
HPRD:07453
MIM:608054
Vega:OTTHUMG00000182715
Other designations: cytochrome P450 2A7|cytochrome P450 IIA4|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7|cytochrome P450IIA4
CYP2A7
Bin Zhao, Yue Liu, Oliver He
CP37
CYPIIIA7
P450-HFLA
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
1551
7q21-q22.1
9606
7
GO_0004497 (EC: ISS); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0019825 (EC: TAS, PMID:2722762); GO_0020037 (EC: IEA); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA)
PMID:1562592; 2492179; 2722762; 2786707; 7894497; 8694864; 9644715; 9890157; 10950848; 11093772; 11137287; 11266076; 11940601; 12406645; 12477932; 12485945; 12690205; 12865317; 14569421; 15128046; 15319333; 15489334; 15698577; 15937338; 15985487; 16041241; 16314882; 16430309; 16635807; 17334880; 17559345; 17582393; 17604264; 17885626; 17936930; 18406467; 18445661; 18537580; 18676680; 18978522; 19064572; 19170196; 19275551; 19343046; 19424794; 19585271; 19593168; 19625176; 19692168; 19801957; 19842932; 20118548; 20147896; 20345875; 20529763; 20615193; 20621111; 20634891; 20637317; 22253426; 22277676; 23143891
cytochrome P450, family 3, subfamily A, polypeptide 7
Ensembl:ENSG00000160870
HGNC:2640
HPRD:05630
MIM:605340
Vega:OTTHUMG00000156726
Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 3A7|cytochrome P450, subfamily IIIA, polypeptide 7|cytochrome P450-HFLA|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP3A7
Bin Zhao, Yue Liu, Oliver He
CPAD
CYP2A
CYPIIA13
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
1553
19q13.2
9606
19
GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0020037 (EC: IDA, PMID:17428784); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA)
PMID:7581481; 7668294; 8587134; 8889548; 9890157; 10353262; 11016631; 12130698; 12721789; 12920161; 14633739; 15063809; 15115698; 15128046; 15196988; 15222883; 15333516; 15618722; 16316926; 16835796; 17428784; 18669584; 19290787; 19303722; 19343046; 19414505; 19789190; 19812523; 20431511; 20534012; 20568895; 20798279; 20846153; 21473878; 22315333; 22397853; 22696418; 22700965; 22798551; 22890016; 23463547; 23583631; 23602888; 23752126; 23917075
cytochrome P450, family 2, subfamily A, polypeptide 13
Ensembl:ENSG00000197838
HGNC:2608
HPRD:07454
MIM:608055
Vega:OTTHUMG00000182762
Other designations: cytochrome P450 2A13|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
CYP2A13
Bin Zhao, Yue Liu, Oliver He
CPB6
CYP2B
CYP2B7
CYP2B7P
CYPIIB6
EFVM
IIB1
P450
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
1555
19q13.2
9606
19
GO_0004497 (EC: IDA, PMID:19651758); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: IDA); GO_0006805 (EC: TAS); GO_0008202 (EC: IMP, PMID:18356043); GO_0016712 (EC: IEA); GO_0017144 (EC: IDA, PMID:19651758); GO_0017144 (EC: IMP, PMID:18356043); GO_0020037 (EC: IDA); GO_0042180 (EC: IDA, PMID:19651758); GO_0042738 (EC: IDA, PMID:19029318); GO_0044281 (EC: TAS); GO_0055114 (EC: IDA, PMID:19651758)
PMID:2308828; 2573390; 2813061; 2899870; 7668294; 8432525; 8587134; 9179987; 9890157; 10037683; 10471061; 10768437; 11243870; 11298076; 11353758; 11470993; 11602525; 11991950; 12207635; 12242601; 12439223; 12477932; 12490624; 12571232; 12629583; 12642465; 12721789; 12738724; 12814665; 14515060; 14977870; 15039299; 15057824; 15128046; 15178651; 15190123; 15194512; 15248218; 15284537; 15319333; 15383491; 15469410; 15563456; 15572372; 15622315; 15825040; 15864119; 16116487; 16125881; 16183265; 16267764; 16338275; 16392089; 16433869; 16495778; 16506047; 16538176; 16623664; 16772608; 16815693; 16912957; 16951995; 17015050; 17047492; 17054410; 17178267; 17223085; 17235330; 17329992; 17352764; 17356468; 17391322; 17407229; 17455229; 17465455; 17502835; 17559344; 17638512; 17654295; 17682072; 17885627; 17900275; 17918089; 18004205; 18024866; 18057928; 18090046; 18171905; 18223457; 18281305; 18287571; 18303024; 18332083; 18356043; 18496131; 18621926; 18728241; 18784455; 18839779; 18854779; 18978480; 18979093; 18989234; 19005482; 19029318; 19074885; 19076156; 19106084; 19124658; 19144407; 19218571; 19225447; 19228205; 19239339; 19282874; 19290787; 19343046; 19371316; 19376514; 19414633; 19425200; 19433561; 19464434; 19467232; 19474465; 19474786; 19486190; 19531981; 19593168; 19651758; 19659438; 19682083; 19693007; 19696793; 19702527; 19704172; 19779319; 19797611; 19812066; 19833192; 19916993; 19926050; 19944064; 20017669; 20079471; 20089352; 20096935; 20136364; 20137387; 20173083; 20179710; 20307138; 20338069; 20350955; 20361990; 20418888; 20459744; 20517174; 20529763; 20583967; 20602615; 20610889; 20622021; 20624854; 20625352; 20639527; 20642445; 20662624; 20668445; 20677014; 20696882; 20720517; 20723261; 20734064; 20841522; 20860463; 20861742; 20876786; 20878158; 20881953; 20952238; 20952418; 20966044; 20970553; 21108329; 21156812; 21158011; 21169260; 21486104; 21694616; 21715435; 21741706; 21746968; 21790905; 21821736; 21886015; 22232427; 22281205; 22397853; 22462748; 22471906; 22519658; 22680342; 22685215; 22815312; 22909231; 22936314; 22942317; 22950382; 23238783; 23249875; 23254426; 23288240; 23298916; 23344581; 23418033; 23524664; 23539296; 23550066; 23615745; 23687222; 23746185; 23837472; 24128861
cytochrome P450, family 2, subfamily B, polypeptide 6
Ensembl:ENSG00000197408
HGNC:2615
HPRD:00477
MIM:123930
Vega:OTTHUMG00000182714
Other designations: 1,4-cineole 2-exo-monooxygenase|cytochrome P450 2B6|cytochrome P450 IIB1|cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
CYP2B6
Bin Zhao, Yue Liu, Oliver He
CPCJ
CYP2C
P450C2C
P450IIC19
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
1557
RP11-400G3.4
10q24
9606
10
GO_0004497 (EC: IDA, PMID:19651758); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: IMP, PMID:18356043); GO_0008395 (EC: IMP, PMID:18356043); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:16401082); GO_0017144 (EC: IDA, PMID:19219744); GO_0018675 (EC: IEA); GO_0018676 (EC: IEA); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0019825 (EC: TAS, PMID:3442670); GO_0019899 (EC: IPI, PMID:15680923); GO_0020037 (EC: IDA); GO_0042738 (EC: IDA, PMID:19029318); GO_0043231 (EC: TAS, PMID:3442670); GO_0044281 (EC: TAS); GO_0046483 (EC: IDA, PMID:19651758); GO_0052741 (EC: IEA); GO_0055114 (EC: IDA, PMID:16401082); GO_0097267 (EC: TAS)
PMID:2009263; 3442670; 7704034; 7969038; 8095407; 8110777; 8195181; 8530044; 8647857; 8894508; 9103550; 9398194; 9435198; 9732415; 9890157; 10022751; 10233205; 10411572; 11037802; 11076863; 11207032; 11240980; 11263781; 11372584; 11474773; 11686476; 11713950; 11763000; 11773867; 11785712; 11791894; 11829201; 11836688; 11865668; 11908757; 11927837; 11950794; 11956668; 12047484; 12121503; 12130704; 12142727; 12171978; 12172336; 12222750; 12235924; 12360109; 12386647; 12419832; 12445035; 12464799; 12468438; 12477932; 12496751; 12534411; 12623762; 12642692; 12656699; 12698310; 12732844; 12809821; 12823155; 12835613; 12879168; 12900870; 12900872; 12919183; 12950145; 12963435; 12975335; 13680037; 14520122; 14583683; 14616425; 14634042; 14634838; 14636465; 14653835; 14659971; 14695703; 14990013; 14998561; 15017629; 15025747; 15039299; 15068562; 15090156; 15119530; 15128046; 15145965; 15164054; 15171646; 15177309; 15205367; 15222046; 15248218; 15284537; 15285851; 15301728; 15319333; 15327595; 15349706; 15371981; 15385836; 15385837; 15447734; 15448955; 15469410; 15496639; 15499191; 15569425; 15590749; 15608563; 15612662; 15639978; 15651900; 15660966; 15662508; 15680923; 15691303; 15691505; 15715938; 15752376; 15776277; 15813658; 15842554; 15855721; 15856433; 15903128; 15932363; 15952098; 15963082; 15963095; 15976989; 16006997; 16012079; 16021435; 16024198; 16025294; 16048566; 16116487; 16133961; 16141610; 16183265; 16198656; 16220110; 16231968; 16232205; 16236141; 16239354; 16261363; 16267764; 16268979; 16307177; 16338275; 16338278; 16338280; 16401082; 16413245; 16487224; 16487225; 16595916; 16638864; 16641871; 16740190; 16771603; 16772608; 16783561; 16789993; 16812949; 16815315; 16815316; 16855453; 16862439; 16863547; 16873909; 16890574; 16890578; 16908943; 16911688; 16912869; 16924387; 16937451; 16946555; 16960452; 17003844; 17047431; 17047492; 17048007; 17052843; 17112810; 17178267; 17201743; 17203292; 17215846; 17269966; 17279092; 17290075; 17295875; 17298483; 17304159; 17357148; 17358097; 17377957; 17407229; 17410461; 17417917; 17418993; 17424941; 17433262; 17439410; 17450472; 17455109; 17487889; 17502835; 17504998; 17559380; 17562299; 17623107; 17625515; 17635176; 17635181; 17666363; 17667801; 17667959; 17680025; 17681590; 17697139; 17697203; 17827141; 17868191; 17875119; 17900275; 17909762; 17922881; 17924835; 17934830; 17966194; 17978853; 17992535; 18004210; 18021343; 18024866; 18057705; 18061941; 18154472; 18205890; 18211619; 18214455; 18223462; 18224311; 18231117; 18240903; 18240905; 18241283; 18241287; 18294333; 18312490; 18319058; 18323861; 18346178; 18356043; 18382661; 18394438; 18399167; 18423013; 18425152; 18466100; 18482659; 18496131; 18496682; 18510611; 18511451; 18518848; 18520596; 18520598; 18521743; 18532997; 18551037; 18577829; 18581106; 18637061; 18641551; 18644391; 18654768; 18676680; 18677622; 18702650; 18751689; 18765869; 18781853; 18823430; 18854779; 18854824; 18936436; 18957504; 18979093; 18982321; 18996102; 19002442; 19025845; 19029318; 19033450; 19038035; 19069365; 19074885; 19102714; 19106083; 19106084; 19108880; 19129087; 19136640; 19139162; 19151603; 19156902; 19164093; 19166419; 19169185; 19170196; 19172254; 19176055; 19192051; 19193675; 19193970; 19199010; 19219744; 19220726; 19236548; 19238367; 19246508; 19259653; 19261446; 19268736; 19290787; 19299322; 19336370; 19337788; 19343046; 19348299; 19350405; 19398604; 19404631; 19407662; 19414633; 19415745; 19415824; 19424794; 19429918; 19430176; 19474452; 19496924; 19499406; 19516253; 19531897; 19534586; 19546880; 19552744; 19576320; 19578179; 19583677; 19593158; 19593168; 19617466; 19621685; 19624462; 19625176; 19636337; 19638460; 19651758; 19661214; 19692168; 19693007; 19696793; 19702490; 19706858; 19712984; 19745563; 19751749; 19761366; 19773541; 19817997; 19821196; 19823875; 19840783; 19841156; 19847408; 19881258; 19884907; 19890215; 19891553; 19904250; 19907421; 19926050; 19928008; 19932784; 19933691; 19934793; 19940233; 19942749; 19954515; 19954746; 19956635; 19961004; 19968574; 20002085; 20015960; 20040040; 20064729; 20078610; 20083681; 20088379; 20113968; 20147896; 20163283; 20173083; 20179710; 20206639; 20207952; 20223877; 20235787; 20236133; 20297661; 20309015; 20349052; 20350051; 20350136; 20351750; 20356512; 20358205; 20360782; 20373852; 20376628; 20390258; 20414645; 20430047; 20457439; 20460345; 20468063; 20492431; 20492467; 20492469; 20499227; 20510210; 20528170; 20529763; 20531370; 20533108; 20549256; 20549497; 20559522; 20565970; 20573087; 20581929; 20602612; 20602615; 20620727; 20633187; 20637959; 20650435; 20665013; 20669013; 20673183; 20679960; 20684753; 20708365; 20716239; 20716514; 20724801; 20801494; 20801498; 20804307; 20823393; 20826260; 20831535; 20831536; 20831548; 20833683; 20838991; 20845077; 20845310; 20857895; 20863179; 20885015; 20890775; 20924183; 20926021; 20941486; 20965456; 20970553; 20976881; 20978260; 20979470; 21038076; 21047200; 21054462; 21054464; 21071160; 21075428; 21079055; 21099121; 21108329; 21108610; 21132257; 21152987; 21160212; 21173785; 21192344; 21212520; 21215696; 21237322; 21247447; 21299635; 21302482; 21315147; 21332417; 21358751; 21380557; 21473286; 21497341; 21507170; 21511217; 21511219; 21527445; 21627593; 21628721; 21689142; 21692828; 21741706; 21766908; 21777277; 21778720; 21786436; 21794898; 21795468; 21798861; 21803320; 21806387; 21826689; 21831410; 21861665; 21862109; 21887904; 21913914; 21913948; 21916910; 21971440; 21972404; 21977947; 22007612; 22028352; 22030270; 22045970; 22070512; 22071359; 22088240; 22116003; 22118006; 22122271; 22123356; 22154242; 22180071; 22183943; 22228204; 22281205; 22304323; 22318618; 22324425; 22374717; 22377481; 22418828; 22425806; 22450429; 22469723; 22476388; 22491019; 22552318; 22585284; 22589111; 22591668; 22612904; 22624833; 22641027; 22648560; 22704413; 22747643; 22785462; 22839512; 22855348; 22873740; 22875498; 22875511; 22913530; 22929815; 22955794; 22971905; 22974728; 22984423; 23001453; 23016454; 23074110; 23081704; 23118231; 23148634; 23175667; 23179471; 23193974; 23257377; 23267857; 23337798; 23340030; 23364775; 23412869; 23413279; 23429358; 23469989; 23470885; 23474843; 23506580; 23517020; 23551241; 23555019; 23556336; 23588332; 23607088; 23618682; 23623526; 23640828; 23645039; 23646118; 23700873; 23736997; 23754447; 23755828; 23793025; 23872648; 23874401; 23886632; 23895809; 24015291; 24088005; 24169346; 24501942
cytochrome P450, family 2, subfamily C, polypeptide 19
HGNC:2621
HPRD:00486
MIM:124020
Other designations: (R)-limonene 6-monooxygenase|(S)-limonene 6-monooxygenase|(S)-limonene 7-monooxygenase|CYPIIC17|CYPIIC19|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450 2C19|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|cytochrome P450-11A|cytochrome P450-254C|flavoprotein-linked monooxygenase|mephenytoin 4'-hydroxylase|mephenytoin 4-hydroxylase|microsomal monooxygenase|xenobiotic monooxygenase
CYP2C19
Bin Zhao, Yue Liu, Oliver He
CPC8
CYPIIC8
MP-12/MP-20
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
1558
10q23.33
9606
10
GO_0004497 (EC: IDA, PMID:19651758); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006082 (EC: IDA, PMID:19651758); GO_0006805 (EC: TAS); GO_0017144 (EC: IDA, PMID:19651758); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0020037 (EC: IEA); GO_0034875 (EC: IDA, PMID:18619574); GO_0042738 (EC: IDA, PMID:18619574); GO_0044281 (EC: TAS); GO_0055114 (EC: IDA, PMID:19651758); GO_0070330 (EC: IEA); GO_0070989 (EC: IDA, PMID:18619574); GO_0097267 (EC: TAS)
PMID:1707679; 2009263; 2216732; 2729895; 3196692; 3500169; 3697070; 7574697; 7704034; 7841444; 8530044; 8870687; 9586955; 9797707; 9842986; 9890157; 10487415; 10704292; 10768437; 10874126; 11668219; 12429347; 12435384; 12477932; 12756196; 12756206; 12920163; 12936704; 14534525; 14646690; 14676196; 15028279; 15039299; 15074466; 15128046; 15289789; 15319333; 15469410; 15469873; 15606441; 15716363; 15785959; 15864120; 15901749; 15933212; 15961978; 16025294; 16141797; 16164496; 16202848; 16253141; 16299241; 16359408; 16372821; 16385451; 16390351; 16475901; 16538176; 16646575; 16856883; 16957870; 17048007; 17175891; 17178266; 17224914; 17241877; 17373732; 17429317; 17558302; 17627038; 17635176; 17670841; 17701008; 17913794; 17923851; 17925548; 17975119; 18216720; 18303964; 18413310; 18496133; 18548238; 18574320; 18594024; 18619574; 18694831; 18769365; 18779360; 18992346; 19023099; 19064572; 19074885; 19129086; 19143748; 19290787; 19339270; 19343046; 19381162; 19415824; 19460752; 19470925; 19480553; 19504558; 19651758; 19706858; 19761371; 19773535; 19833260; 19913121; 19935798; 19954515; 20013305; 20031551; 20136364; 20173083; 20190184; 20212519; 20214592; 20368717; 20375710; 20379614; 20389299; 20436375; 20437850; 20523106; 20529763; 20602612; 20602615; 20628086; 20665013; 20808793; 20848147; 20857895; 20890775; 20970553; 21047199; 21054465; 21059750; 21081644; 21163940; 21173785; 21214863; 21245287; 21270106; 21375401; 21685474; 21697463; 21697548; 21778352; 21791871; 21798861; 21838784; 21977947; 22027337; 22028317; 22028915; 22242967; 22313047; 22339777; 22491019; 22527101; 22542470; 22625877; 22723340; 23118231; 23171856; 23307233; 23336573; 23413280; 23426382; 23755828
cytochrome P450, family 2, subfamily C, polypeptide 8
Ensembl:ENSG00000138115
HGNC:2622
HPRD:03083
MIM:601129
Vega:OTTHUMG00000018804
Other designations: P450 form 1|cytochrome P450 2C8|cytochrome P450 IIC2|cytochrome P450 MP-12|cytochrome P450 MP-20|cytochrome P450 form 1|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase|s-mephenytoin 4-hydroxylase|xenobiotic monooxygenase
CYP2C8
Bin Zhao, Yue Liu, Oliver He
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
1559
RP11-208C17.6
10q24
9606
10
GO_0004497 (EC: IDA, PMID:19651758); GO_0004497 (EC: NAS, PMID:2827463); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0008144 (EC: IDA, PMID:19448135); GO_0008202 (EC: IMP, PMID:18356043); GO_0008395 (EC: IMP, PMID:18356043); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:16401082); GO_0017144 (EC: IDA, PMID:19219744); GO_0017144 (EC: IMP); GO_0018675 (EC: IEA); GO_0018676 (EC: IEA); GO_0019369 (EC: TAS); GO_0019373 (EC: TAS); GO_0019627 (EC: IDA, PMID:19029318); GO_0020037 (EC: IEA); GO_0032787 (EC: IDA, PMID:19651758); GO_0034875 (EC: IDA, PMID:18619574); GO_0042737 (EC: IMP, PMID:18356043); GO_0042738 (EC: IDA, PMID:18619574); GO_0043231 (EC: IDA, PMID:9618440); GO_0043231 (EC: TAS, PMID:2827463); GO_0043603 (EC: IDA, PMID:19651758); GO_0044281 (EC: TAS); GO_0052741 (EC: IEA); GO_0055114 (EC: IDA, PMID:16401082); GO_0070989 (EC: IDA, PMID:18619574); GO_0097267 (EC: TAS)
PMID:1445376; 1857342; 2009263; 2025243; 2827463; 2963808; 3032244; 3079764; 3196692; 3243766; 3697070; 7704034; 7841444; 8095407; 8215449; 8333835; 8530044; 8809086; 8946475; 9110362; 9398194; 9618440; 9663807; 9890157; 10073515; 10704292; 10739176; 11127854; 11186133; 11298075; 11325819; 11372590; 11397381; 11422024; 11434505; 11455026; 11503012; 11588061; 11678789; 11697742; 11740344; 11833786; 11876753; 11893129; 11908757; 11911968; 11926893; 11950794; 11956512; 11960920; 11991950; 12010835; 12047484; 12152005; 12181452; 12207635; 12235454; 12359989; 12360109; 12406644; 12414349; 12419832; 12426520; 12435384; 12445031; 12451434; 12464247; 12477932; 12496751; 12509498; 12534640; 12559973; 12603175; 12621390; 12634980; 12668916; 12682803; 12698304; 12728288; 12732844; 12734606; 12800253; 12803577; 12805007; 12844136; 12861225; 12879168; 12891229; 12900870; 12913403; 12950145; 14500040; 14504850; 14520122; 14583800; 14614357; 14616425; 14634042; 14634838; 14646690; 14656880; 14661864; 14676821; 14691573; 14691574; 14707031; 14726986; 14739630; 15001971; 15001972; 15005635; 15024534; 15039299; 15048614; 15050794; 15061384; 15066644; 15070684; 15090156; 15100169; 15102864; 15116052; 15116053; 15128046; 15128048; 15145963; 15175798; 15177309; 15197523; 15199455; 15213846; 15222661; 15226678; 15229460; 15248218; 15260906; 15284535; 15284536; 15289788; 15290664; 15369736; 15370961; 15371982; 15385837; 15452553; 15469410; 15536456; 15569425; 15569819; 15588114; 15592327; 15606435; 15606441; 15608560; 15617742; 15632378; 15660966; 15691505; 15714076; 15742978; 15776277; 15790782; 15795654; 15813658; 15824753; 15841315; 15842554; 15855721; 15888487; 15889670; 15896241; 15900281; 15900282; 15919766; 15924351; 15940194; 15947090; 15961979; 15963101; 15970795; 16006997; 16025294; 16082538; 16094537; 16099926; 16111713; 16116487; 16141794; 16141797; 16160068; 16183265; 16187974; 16198655; 16198656; 16202848; 16220110; 16232205; 16236141; 16253141; 16268502; 16297214; 16303885; 16305586; 16305587; 16321620; 16325295; 16338275; 16342679; 16372821; 16385451; 16401082; 16413010; 16424822; 16432637; 16538176; 16541193; 16552506; 16580898; 16595916; 16611750; 16627267; 16630605; 16635054; 16638864; 16639745; 16646575; 16676068; 16699986; 16708125; 16740353; 16749864; 16771603; 16784736; 16797247; 16815313; 16847429; 16847664; 16863464; 16873909; 16878445; 16882880; 16890578; 16924387; 16957870; 16969365; 16985026; 16985032; 17015052; 17048007; 17049586; 17085674; 17110455; 17111199; 17157122; 17167248; 17178267; 17192772; 17201743; 17226852; 17269966; 17279092; 17298483; 17301738; 17304159; 17324110; 17325732; 17329986; 17332144; 17368604; 17391071; 17397249; 17413769; 17418993; 17419358; 17446262; 17460547; 17479200; 17504998; 17510308; 17558303; 17562299; 17572144; 17577464; 17596133; 17596671; 17597710; 17603219; 17627011; 17627038; 17635176; 17635181; 17635185; 17653141; 17681167; 17686967; 17721328; 17764537; 17827141; 17827526; 17849045; 17851566; 17868191; 17895500; 17899045; 17900275; 17955230; 17989110; 18021343; 18024866; 18030307; 18034618; 18034619; 18061941; 18154472; 18183038; 18204476; 18211048; 18216720; 18231117; 18240903; 18240905; 18252229; 18281915; 18303964; 18305455; 18310303; 18315785; 18322281; 18340006; 18356043; 18370846; 18375260; 18378563; 18399713; 18419640; 18425152; 18429757; 18466099; 18480003; 18485885; 18496131; 18496133; 18496682; 18510611; 18511451; 18516070; 18535201; 18542936; 18548238; 18552123; 18559094; 18570163; 18574025; 18597650; 18619574; 18629445; 18662264; 18669935; 18680736; 18681789; 18690342; 18694831; 18698879; 18754001; 18754597; 18756910; 18781852; 18793590; 18816302; 18836275; 18854779; 18855533; 18922023; 18936436; 18950464; 18971529; 18990750; 18992148; 18992263; 18992346; 18996102; 19005461; 19010418; 19018719; 19026171; 19029318; 19031075; 19053752; 19064572; 19074728; 19074885; 19077919; 19082874; 19099951; 19106084; 19117406; 19135231; 19136640; 19139476; 19151603; 19164093; 19177029; 19181737; 19192051; 19199010; 19202563; 19207028; 19219744; 19221727; 19223558; 19225451; 19233181; 19233910; 19258521; 19280158; 19290787; 19297219; 19300499; 19319511; 19324988; 19336370; 19337788; 19339270; 19343046; 19350405; 19369937; 19381162; 19381164; 19387626; 19414633; 19415745; 19415824; 19420105; 19424794; 19448135; 19450127; 19474452; 19480553; 19495518; 19534586; 19538716; 19538885; 19541511; 19541829; 19545555; 19546880; 19567378; 19578179; 19581657; 19593158; 19593168; 19593208; 19604036; 19605743; 19615687; 19617466; 19651758; 19652664; 19663669; 19663817; 19669737; 19692168; 19696793; 19706858; 19736056; 19745563; 19761366; 19794411; 19822571; 19823875; 19833260; 19847408; 19874474; 19881396; 19891553; 19891554; 19899329; 19903527; 19913121; 19925388; 19926050; 19934028; 19934793; 19935798; 19941044; 19942260; 19952982; 19954515; 19956635; 19958090; 19995889; 20020283; 20029944; 20031551; 20043560; 20064729; 20072124; 20073138; 20075209; 20088379; 20089352; 20102361; 20117066; 20121287; 20131310; 20136364; 20147896; 20149073; 20150829; 20167002; 20173083; 20179710; 20204461; 20207952; 20210733; 20226775; 20228265; 20235787; 20297661; 20339191; 20339978; 20351714; 20354686; 20359257; 20373852; 20375710; 20375999; 20376629; 20381283; 20386359; 20390258; 20403997; 20421126; 20430047; 20434758; 20436375; 20437850; 20442691; 20445534; 20453000; 20458343; 20459419; 20459744; 20488169; 20499136; 20504253; 20529763; 20553802; 20555338; 20569971; 20585445; 20585834; 20597268; 20602612; 20602615; 20602621; 20615525; 20628086; 20637959; 20653674; 20653676; 20656072; 20665013; 20677151; 20679960; 20709439; 20716240; 20722625; 20733952; 20808793; 20811787; 20815369; 20831047; 20831536; 20833655; 20833683; 20833980; 20842355; 20845310; 20852447; 20854800; 20857895; 20884456; 20885015; 20930419; 20937634; 20941486; 20946155; 20962433; 20970553; 21044367; 21047199; 21057703; 21063236; 21068649; 21071160; 21108610; 21110192; 21148049; 21160360; 21163940; 21167292; 21173785; 21213107; 21215088; 21248432; 21292004; 21334530; 21371265; 21375401; 21451434; 21493749; 21533175; 21537551; 21544933; 21597400; 21605066; 21638223; 21639946; 21651319; 21691805; 21692828; 21725053; 21757329; 21766908; 21768671; 21786578; 21798861; 21852944; 21861665; 21883387; 21977947; 21985811; 21988832; 22023024; 22075408; 22075505; 22108774; 22188360; 22198820; 22252093; 22272893; 22288731; 22289258; 22290467; 22294058; 22378156; 22393834; 22409277; 22452429; 22528326; 22533669; 22534826; 22542470; 22547083; 22571356; 22589111; 22641027; 22735459; 22808915; 22842957; 22854539; 22855348; 22918969; 22941809; 22952875; 23065265; 23081681; 23081704; 23089473; 23099353; 23113310; 23118231; 23145098; 23159358; 23159639; 23171336; 23183958; 23201087; 23279643; 23376925; 23446815; 23469989; 23473641; 23481074; 23556337; 23563037; 23577132; 23582453; 23586031; 23615745; 23651023; 23726967; 23732294; 23755828; 23774101; 23863877; 23930675
cytochrome P450, family 2, subfamily C, polypeptide 9
Ensembl:ENSG00000138109
HGNC:2623
HPRD:03084
MIM:601130
Vega:OTTHUMG00000018805
Other designations: cytochrome P-450 S-mephenytoin 4-hydroxylase|cytochrome P-450MP|cytochrome P450 2C9|cytochrome P450 PB-1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP2C9
Bin Zhao, Yue Liu, Oliver He
CPCI
CYP2C
CYP2C17
P450-6B/29C
P450IIC17
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
1562
RP11-466J14.4
10q24
9606
10
GO_0004497 (EC: TAS, PMID:8110777); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0019825 (EC: TAS, PMID:8110777); GO_0020037 (EC: IEA); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA)
PMID:1306110; 1896026; 2009263; 7704034; 8095407; 8110777; 8125298; 8333835; 9028867; 9154796; 9797707; 9890157; 10487415; 10704292; 10768437; 11093772; 12378636; 12477932; 12694732; 15128046; 15164054; 15302935; 15319333; 15489334; 16359177; 16385451; 17048007; 17207965; 19038035; 19074885; 19204726; 19290787; 19578179; 19706858; 19751749; 19958090; 20045989; 20453000; 20529763; 21163940; 21798861; 21988832; 23755828
cytochrome P450, family 2, subfamily C, polypeptide 18
Ensembl:ENSG00000108242
HGNC:2620
HPRD:03085
MIM:601131
Vega:OTTHUMG00000018796
Other designations: (S)-mephenytoin hydroxylase associated cytochrome P450|CYPIIC18|cytochrome P450 2C18|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18|cytochrome P450-6B/29C|flavoprotein-linked monooxygenase|microsomal monooxygenase|unspecific monooxygenase
CYP2C18
Bin Zhao, Yue Liu, Oliver He
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
1565
RP4-669P10.2
22q13.1
9606
22
GO_0004497 (EC: IDA, PMID:15327587); GO_0005506 (EC: IEA); GO_0005739 (EC: IDA, PMID:19438707); GO_0005783 (EC: TAS, PMID:19438707); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS, PMID:19438707); GO_0008144 (EC: IDA, PMID:19448135); GO_0008202 (EC: IMP, PMID:18356043); GO_0009804 (EC: IDA, PMID:19438707); GO_0009820 (EC: IDA, PMID:19651758); GO_0009822 (EC: IDA, PMID:15039299); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:15039299); GO_0017144 (EC: IDA, PMID:19219744); GO_0017144 (EC: IMP, PMID:18356043); GO_0020037 (EC: IDA, PMID:16352597); GO_0033076 (EC: IDA, PMID:19448135); GO_0042737 (EC: IDA, PMID:15039299); GO_0044281 (EC: TAS); GO_0046483 (EC: IDA, PMID:15327587); GO_0051100 (EC: IDA, PMID:19448135); GO_0055114 (EC: IDA, PMID:16401082); GO_0070330 (EC: IEA); GO_0070989 (EC: IDA, PMID:15039299); GO_0090350 (EC: IDA, PMID:19448135)
PMID:1673290; 1844820; 1978251; 1978565; 2211621; 2466049; 2574001; 3123997; 3410476; 7845481; 7868129; 7903454; 7927337; 7951238; 8287064; 8449513; 8530011; 8634695; 8655150; 8971426; 9241659; 9264312; 9890157; 10064570; 10233205; 10493260; 10675100; 11037800; 11037802; 11055624; 11097351; 11097352; 11147929; 11204351; 11207030; 11207032; 11214775; 11266079; 11285084; 11291049; 11294012; 11295783; 11303596; 11372584; 11376189; 11422605; 11422615; 11442888; 11470994; 11477317; 11505218; 11505219; 11520401; 11549206; 11560558; 11668217; 11682257; 11702057; 11735606; 11741249; 11750286; 11751440; 11753271; 11753272; 11763000; 11778144; 11791895; 11809184; 11816009; 11829201; 11895912; 11901361; 11927839; 11940091; 12006905; 12063626; 12065557; 12077255; 12089164; 12106691; 12107620; 12142727; 12152006; 12171760; 12171978; 12172215; 12172336; 12175908; 12177686; 12187002; 12191703; 12206675; 12207635; 12210290; 12360109; 12386645; 12386646; 12392820; 12404686; 12419832; 12421483; 12422998; 12426523; 12438554; 12439227; 12446689; 12459840; 12468438; 12477932; 12486288; 12490310; 12503836; 12536989; 12548461; 12569554; 12579870; 12589966; 12610741; 12616663; 12622923; 12629505; 12651805; 12657030; 12691769; 12728976; 12734765; 12743673; 12748560; 12756206; 12756210; 12766554; 12782969; 12784098; 12861292; 12879168; 12879776; 12883230; 12893130; 12900870; 12900872; 12911679; 12915955; 12919180; 12942225; 12950145; 12960748; 12963435; 13680033; 14499311; 14499440; 14514498; 14515061; 14520122; 14557687; 14571354; 14602525; 14624403; 14635107; 14639062; 14640293; 14652703; 14653957; 14658041; 14716707; 14726620; 14726986; 14748763; 14985156; 14991823; 15005635; 15039299; 15048614; 15051713; 15061826; 15068562; 15090156; 15108188; 15115913; 15116051; 15118351; 15128046; 15149890; 15177309; 15205367; 15237854; 15256524; 15260906; 15289790; 15313161; 15319333; 15327587; 15330195; 15349705; 15349706; 15382273; 15461802; 15469410; 15469888; 15470329; 15484318; 15489334; 15499201; 15538128; 15584944; 15588859; 15590749; 15592325; 15618665; 15625333; 15632378; 15646732; 15648054; 15651900; 15669884; 15680923; 15690482; 15691505; 15708542; 15726636; 15729081; 15731591; 15764408; 15768052; 15769360; 15770075; 15774926; 15813658; 15817819; 15820320; 15843230; 15855722; 15861039; 15914211; 15932952; 15952058; 15970126; 15987423; 16006997; 16024198; 16025294; 16037945; 16048566; 16079496; 16130179; 16141609; 16160620; 16162505; 16189709; 16198657; 16205777; 16220080; 16236141; 16239355; 16249913; 16272752; 16283274; 16294366; 16315032; 16337409; 16352597; 16361630; 16401082; 16415111; 16423440; 16459354; 16466686; 16476126; 16478753; 16490169; 16493615; 16534507; 16537246; 16544144; 16550211; 16551910; 16584388; 16595916; 16611538; 16633140; 16633141; 16638736; 16638864; 16642541; 16679388; 16712791; 16716118; 16771603; 16775389; 16778723; 16812949; 16815318; 16819548; 16833023; 16835697; 16845507; 16849011; 16855473; 16858124; 16864175; 16880622; 16924387; 16960721; 17038884; 17089107; 17102541; 17113562; 17115111; 17178267; 17186005; 17194620; 17224713; 17225875; 17234366; 17241532; 17242628; 17244352; 17250723; 17259947; 17270484; 17289397; 17297618; 17301689; 17304721; 17311358; 17324244; 17325735; 17329852; 17361124; 17374963; 17392730; 17418993; 17431033; 17442289; 17449559; 17450472; 17454842; 17460029; 17470523; 17479406; 17503978; 17517247; 17530572; 17536768; 17541883; 17547692; 17554527; 17568504; 17570739; 17573783; 17581325; 17609736; 17610534; 17624022; 17635181; 17635183; 17667795; 17667959; 17697394; 17700359; 17701031; 17713466; 17714084; 17715206; 17725248; 17761971; 17764479; 17803873; 17828532; 17882159; 17908053; 17909762; 17921051; 17947222; 17957765; 17965519; 17965522; 17966194; 17971818; 17992535; 18024866; 18034624; 18048313; 18061941; 18070221; 18075468; 18086475; 18165569; 18167502; 18183034; 18197300; 18202841; 18204346; 18211048; 18214456; 18214849; 18223460; 18231117; 18240905; 18258609; 18261353; 18280655; 18287869; 18294285; 18300942; 18304900; 18317231; 18327668; 18346175; 18346782; 18356043; 18372530; 18382661; 18384443; 18401578; 18407954; 18414197; 18423013; 18425152; 18425996; 18429752; 18433425; 18445827; 18474629; 18474679; 18480698; 18520596; 18520597; 18543297; 18545991; 18547414; 18551040; 18553077; 18583979; 18597648; 18618215; 18625943; 18632250; 18641553; 18648788; 18663559; 18666237; 18676680; 18681789; 18690546; 18698000; 18708991; 18713907; 18719619; 18725510; 18728242; 18754843; 18784265; 18784654; 18794098; 18794105; 18797858; 18818748; 18827765; 18834373; 18840375; 18927241; 18958918; 18978520; 18979093; 18996102; 19000552; 19000940; 19001559; 19019335; 19024387; 19025845; 19032724; 19033450; 19037197; 19047159; 19071885; 19082882; 19094446; 19095219; 19142106; 19151603; 19153830; 19156902; 19162321; 19164093; 19169185; 19170196; 19189210; 19189212; 19192051; 19194367; 19219744; 19219857; 19225771; 19242697; 19284319; 19290787; 19296901; 19303860; 19308365; 19320528; 19330589; 19336370; 19343046; 19350405; 19356055; 19357842; 19364831; 19365402; 19374513; 19387424; 19387994; 19395173; 19405050; 19421167; 19429471; 19437119; 19438707; 19444434; 19448135; 19470220; 19474452; 19512959; 19521114; 19523031; 19527514; 19537956; 19575027; 19593158; 19593168; 19593180; 19593802; 19596663; 19597703; 19604081; 19604084; 19604091; 19625176; 19636337; 19651758; 19652678; 19656108; 19660006; 19692168; 19694742; 19702490; 19710640; 19710642; 19715474; 19719813; 19738170; 19761369; 19781968; 19797609; 19809024; 19823875; 19833260; 19840783; 19866496; 19887477; 19891553; 19892789; 19902987; 19907421; 19910717; 19937844; 19940985; 19946748; 19947517; 19953095; 19954080; 19954746; 19956635; 19995332; 19997080; 20007670; 20009880; 20031551; 20041956; 20075642; 20081063; 20118554; 20124171; 20133509; 20136364; 20137387; 20147896; 20173083; 20174590; 20185366; 20195825; 20201714; 20205348; 20206139; 20225176; 20297661; 20305604; 20309015; 20332423; 20335142; 20350136; 20364044; 20368706; 20373852; 20375710; 20385997; 20421845; 20430047; 20432045; 20435235; 20454926; 20456744; 20459744; 20461808; 20467479; 20473659; 20489028; 20492431; 20515869; 20520586; 20530222; 20531370; 20547595; 20563569; 20565970; 20574415; 20588073; 20590587; 20590588; 20597905; 20599499; 20602615; 20628863; 20634891; 20643254; 20656020; 20656072; 20679960; 20684753; 20686235; 20700584; 20701904; 20727252; 20731819; 20799519; 20809362; 20814331; 20827267; 20828547; 20846929; 20849243; 20851451; 20857895; 20859244; 20863179; 20877299; 20877302; 20878561; 20881950; 20925579; 20970553; 21063774; 21071160; 21072184; 21108610; 21135868; 21140323; 21173786; 21241245; 21248727; 21321564; 21391885; 21430657; 21433154; 21437611; 21449914; 21456632; 21485696; 21486104; 21518482; 21527579; 21543662; 21589866; 21596874; 21599570; 21605066; 21631295; 21677335; 21728792; 21743374; 21749835; 21787170; 21797939; 21803659; 21821735; 21823108; 21826689; 21835244; 21840870; 21860550; 21861665; 21880792; 21907728; 21913948; 21918425; 21956465; 21958961; 21971440; 21989258; 22039821; 22092298; 22109568; 22141351; 22159753; 22180068; 22180372; 22198443; 22216145; 22245658; 22277677; 22281720; 22301406; 22303032; 22308038; 22324840; 22355045; 22398969; 22399238; 22428763; 22459173; 22497725; 22531512; 22623212; 22623266; 22661184; 22688624; 22700965; 22735900; 22775532; 22777153; 22803153; 22905959; 22913530; 22929407; 22948856; 22986607; 22994728; 23167378; 23207012; 23212934; 23213055; 23258538; 23277250; 23280482; 23289191; 23292115; 23350374; 23357843; 23394389; 23469064; 23471717; 23503455; 23552177; 23555934; 23558964; 23570465; 23609392; 23644254; 23664723; 23686417; 23691026; 23700791; 23712329; 23733622; 23734807; 23737191; 23781139; 23803265; 23809878; 23842856; 23851570; 23855716; 23870808; 23872830; 23893861
cytochrome P450, family 2, subfamily D, polypeptide 6
Ensembl:ENSG00000100197
HGNC:2625
HPRD:00487
MIM:124030
Vega:OTTHUMG00000150918
Other designations: cytochrome P450 2D6|cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2|cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2|cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1|cytochrome P450-DB1|debrisoquine 4-hydroxylase|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP2D6
Bin Zhao, Yue Liu, Oliver He
CPE1
CYP2E
P450-J
P450C2E
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
1571
10q26.3
9606
10
GO_0000139 (EC: IEA); GO_0004497 (EC: IDA, PMID:19651758); GO_0005506 (EC: IEA); GO_0005739 (EC: IEA); GO_0005789 (EC: TAS); GO_0006641 (EC: IEA); GO_0006805 (EC: TAS); GO_0008202 (EC: IMP, PMID:18356043); GO_0010193 (EC: IEA); GO_0010243 (EC: IEA); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:16401082); GO_0016709 (EC: TAS, PMID:18818195); GO_0016712 (EC: IEA); GO_0017144 (EC: IDA, PMID:19219744); GO_0017144 (EC: IMP, PMID:18356043); GO_0019825 (EC: TAS, PMID:3233219); GO_0019899 (EC: IPI, PMID:15680923); GO_0020037 (EC: IDA, PMID:18818195); GO_0031227 (EC: IEA); GO_0042493 (EC: IEA); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0046483 (EC: IDA, PMID:19651758); GO_0055114 (EC: IDA, PMID:16401082)
PMID:1719479; 1778977; 2587619; 3233219; 3675576; 3782137; 7529759; 7733943; 7773503; 8031147; 8307581; 8809087; 9058590; 9129165; 9398194; 9834965; 9890157; 9918138; 10620320; 10731522; 10741631; 11051375; 11104220; 11191882; 11198676; 11207032; 11236836; 11259352; 11263781; 11275366; 11305777; 11331106; 11377232; 11389775; 11406608; 11410713; 11422615; 11503278; 11520401; 11535247; 11535253; 11641039; 11675150; 11696658; 11697456; 11700262; 11701230; 11719088; 11746208; 11748356; 11751440; 11756225; 11766168; 11774269; 11776598; 11782477; 11798822; 11802217; 11815398; 11854903; 11869835; 11895912; 11907164; 11911601; 11960914; 11964928; 11966948; 12010862; 12047484; 12055050; 12063626; 12080432; 12115524; 12172927; 12198369; 12211622; 12351530; 12355548; 12365037; 12376502; 12376511; 12397416; 12403788; 12452057; 12454736; 12460800; 12469218; 12477932; 12490624; 12540498; 12548461; 12552594; 12554615; 12561466; 12563175; 12569554; 12579334; 12601351; 12668988; 12705718; 12707490; 12710951; 12718576; 12718671; 12721789; 12732844; 12738724; 12739102; 12759747; 12760253; 12767509; 12771559; 12774019; 12777398; 12777962; 12777965; 12813050; 12824748; 12824892; 12851035; 12860273; 12883487; 12883749; 12915519; 12939804; 12940444; 12960506; 14499622; 14500779; 14510941; 14527082; 14535982; 14578150; 14606109; 14634838; 14646291; 14661969; 14669323; 14681495; 14691069; 14695651; 14695664; 14696128; 14751678; 14757192; 14991750; 15036355; 15039299; 15061915; 15064998; 15066574; 15112335; 15125228; 15128046; 15138035; 15162526; 15177663; 15182482; 15215328; 15220553; 15226677; 15289170; 15318112; 15327835; 15349722; 15355699; 15370874; 15469410; 15491310; 15519646; 15532721; 15536330; 15632182; 15633127; 15640066; 15646021; 15660387; 15680923; 15712341; 15714076; 15734972; 15753073; 15763499; 15769360; 15774926; 15780023; 15793883; 15849806; 15899651; 15902904; 15914211; 15914277; 15928955; 15938845; 15952134; 15961886; 15968714; 15991278; 16006997; 16019049; 16039674; 16043197; 16052683; 16125881; 16126235; 16137184; 16142352; 16172237; 16235983; 16235992; 16253141; 16311924; 16324524; 16337880; 16365683; 16372174; 16380384; 16385451; 16393248; 16401082; 16424825; 16425414; 16440362; 16459354; 16470306; 16471212; 16484137; 16488179; 16497268; 16535827; 16551616; 16600530; 16634857; 16679316; 16720291; 16721740; 16758119; 16770646; 16834659; 16837478; 16841220; 16962935; 16985026; 16985032; 17007050; 17016589; 17022435; 17034788; 17059334; 17078101; 17118447; 17119198; 17119944; 17134659; 17146594; 17156750; 17176083; 17178637; 17219769; 17264406; 17284772; 17292341; 17331164; 17361553; 17367411; 17373732; 17380320; 17384900; 17427487; 17440116; 17442289; 17486761; 17498780; 17559142; 17564586; 17577619; 17584020; 17603900; 17611777; 17617119; 17627011; 17659824; 17695473; 17885617; 17916905; 17935737; 17950035; 17963298; 17996038; 18025800; 18028774; 18034693; 18056994; 18211048; 18218609; 18231117; 18258609; 18261353; 18304215; 18322963; 18327668; 18356043; 18369917; 18418580; 18420361; 18423013; 18446064; 18460770; 18466102; 18472009; 18473182; 18497573; 18507060; 18510611; 18544910; 18550589; 18569579; 18569587; 18569591; 18628434; 18636124; 18642288; 18645668; 18663376; 18676680; 18698632; 18713495; 18715838; 18726416; 18769766; 18773092; 18798002; 18798003; 18801337; 18818195; 18936436; 18990750; 18992148; 19012698; 19058336; 19064572; 19074885; 19096130; 19115622; 19124503; 19131562; 19157621; 19157724; 19170196; 19190172; 19219744; 19230487; 19250143; 19267064; 19288740; 19290787; 19334053; 19336370; 19339548; 19343046; 19351467; 19357030; 19381774; 19382518; 19390575; 19428381; 19442564; 19481674; 19484729; 19489076; 19492240; 19506726; 19521675; 19528831; 19537956; 19575027; 19625176; 19643819; 19651758; 19655364; 19686770; 19692168; 19706845; 19751749; 19761367; 19786980; 19789190; 19796841; 19805575; 19822571; 19826048; 19860798; 19874574; 19887496; 19891553; 19913121; 19927646; 19948975; 19956635; 19958676; 19963114; 19963139; 20026093; 20029944; 20031389; 20093049; 20095411; 20100563; 20100738; 20101753; 20102722; 20117323; 20131310; 20171022; 20173083; 20180013; 20195803; 20364586; 20392357; 20394984; 20401433; 20404016; 20406102; 20426969; 20437058; 20453000; 20463018; 20511665; 20529763; 20554493; 20556843; 20576306; 20598484; 20602615; 20628086; 20634891; 20637790; 20661821; 20663217; 20675267; 20692331; 20715111; 20819434; 20932821; 20939108; 20941486; 20957336; 20958328; 20969746; 21072184; 21076874; 21209460; 21228414; 21261721; 21265876; 21281483; 21295098; 21360299; 21385088; 21553050; 21557999; 21590276; 21705789; 21729529; 21745589; 21856753; 21869556; 21895718; 21988832; 22012226; 22077825; 22088806; 22109568; 22126492; 22155602; 22156006; 22222162; 22228187; 22230367; 22238121; 22249978; 22251540; 22335459; 22342293; 22384697; 22392284; 22436864; 22442693; 22485222; 22506592; 22589738; 22591346; 22606226; 22613106; 22614694; 22761909; 22788240; 22807108; 22815852; 22954124; 22957075; 22997752; 23007992; 23066397; 23077626; 23104821; 23124075; 23131254; 23139769; 23186213; 23193974; 23193996; 23244081; 23251661; 23335995; 23355335; 23363738; 23394127; 23404349; 23418369; 23454624; 23460870; 23471973; 23530020; 23534720; 23583009; 23595220; 23628324; 23632049; 23636797; 23660503; 23707663; 23875638; 23886179; 23934444; 24113184; 24333271
cytochrome P450, family 2, subfamily E, polypeptide 1
Ensembl:ENSG00000130649
HGNC:2631
HPRD:11813
MIM:124040
Vega:OTTHUMG00000019322
Other designations: 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP2E1
Bin Zhao, Yue Liu, Oliver He
C2F1
CYP2F
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
1572
19q13.2
9606
19
GO_0004497 (EC: TAS, PMID:1974816); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0009636 (EC: IEA); GO_0016712 (EC: IDA, PMID:10383923); GO_0018931 (EC: IDA, PMID:10383923); GO_0018979 (EC: IEA); GO_0019825 (EC: IEA); GO_0020037 (EC: IEA); GO_0043231 (EC: IDA, PMID:10383923); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA)
PMID:1974816; 2045106; 8432525; 8587134; 8619884; 9539103; 10383923; 11827709; 12477932; 12598524; 15128046; 16883522; 17327131; 17943660; 19343046; 20198857; 22232929; 22397853
cytochrome P450, family 2, subfamily F, polypeptide 1
Ensembl:ENSG00000197446
HGNC:2632
HPRD:00490
MIM:124070
Vega:OTTHUMG00000167412
Other designations: CYPIIF1|cytochrome P450 2F1|cytochrome P450, subfamily IIF, polypeptide 1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP2F1
Bin Zhao, Yue Liu, Oliver He
CPJ2
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
1573
1p31.3-p31.2
9606
1
GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006690 (EC: TAS, PMID:8631948); GO_0006805 (EC: TAS, PMID:11901223); GO_0008016 (EC: TAS, PMID:8631948); GO_0008392 (EC: IDA, PMID:11901223); GO_0008404 (EC: IDA, PMID:11901223); GO_0008405 (EC: IDA, PMID:11901223); GO_0019369 (EC: TAS); GO_0019373 (EC: IDA, PMID:11901223); GO_0019373 (EC: TAS); GO_0020037 (EC: IEA); GO_0043651 (EC: IDA, PMID:11901223); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA); GO_0071614 (EC: IDA, PMID:11901223)
PMID:8631948; 8913342; 9048644; 9187259; 9570962; 10065373; 10405341; 10681399; 10828211; 11901223; 12386130; 12477932; 12737630; 14575523; 14702039; 15128046; 15256482; 15361551; 15466638; 15489334; 15861034; 15864120; 16008525; 16182271; 16202848; 16842392; 16957870; 17126841; 17162467; 17286575; 17327508; 17429317; 17470359; 17475630; 17638876; 17705402; 17979511; 18004755; 18216721; 18219097; 18303964; 18496133; 18675280; 18729130; 18769365; 19105833; 19290787; 19420105; 19448409; 19550113; 19576320; 19578796; 19615687; 19823578; 19851119; 19913121; 19923256; 20140850; 20173083; 20379614; 20480811; 20597138; 20628086; 21030485; 21059750; 21642892; 21988832; 22028915; 22232929; 22731644; 22761738; 23155181; 23647230; 23661295; 23684773; 23696562
cytochrome P450, family 2, subfamily J, polypeptide 2
Ensembl:ENSG00000134716
HGNC:2634
HPRD:03159
MIM:601258
Vega:OTTHUMG00000008991
Other designations: CYPIIJ2|arachidonic acid epoxygenase|cytochrome P450 2J2|cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2|flavoprotein-linked monooxygenase|microsomal monooxygenase
CYP2J2
Bin Zhao, Yue Liu, Oliver He
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
1576
7q21.1
9606
7
GO_0004497 (EC: IDA, PMID:15327587); GO_0004497 (EC: ISS); GO_0005496 (EC: IDA, PMID:15256616); GO_0005506 (EC: IDA, PMID:15256616); GO_0005737 (EC: IDA, PMID:18446064); GO_0005789 (EC: TAS); GO_0006629 (EC: TAS, PMID:2492107); GO_0006706 (EC: IMP, PMID:18356043); GO_0006805 (EC: TAS); GO_0008202 (EC: IMP, PMID:3259858); GO_0008209 (EC: TAS, PMID:19651758); GO_0008395 (EC: IMP, PMID:18356043); GO_0009822 (EC: IDA, PMID:15039299); GO_0016021 (EC: IEA); GO_0016098 (EC: IDA, PMID:16401082); GO_0016491 (EC: IDA, PMID:15039299); GO_0016712 (EC: IEA); GO_0017144 (EC: IDA, PMID:15327587); GO_0019825 (EC: TAS, PMID:2492107); GO_0019899 (EC: IPI, PMID:15680923); GO_0020037 (EC: IEA); GO_0030343 (EC: IDA, PMID:15546903); GO_0033780 (EC: IEA); GO_0034875 (EC: IDA, PMID:18619574); GO_0036378 (EC: IDA, PMID:15546903); GO_0042359 (EC: IC, PMID:15546903); GO_0042737 (EC: IDA, PMID:15039299); GO_0042737 (EC: IMP, PMID:18356043); GO_0042738 (EC: IDA, PMID:18619574); GO_0043231 (EC: TAS, PMID:3460094); GO_0044281 (EC: TAS); GO_0046483 (EC: IDA, PMID:15327587); GO_0047638 (EC: IEA); GO_0050591 (EC: IEA); GO_0050649 (EC: IMP, PMID:3259858); GO_0055114 (EC: IDA, PMID:16401082); GO_0070576 (EC: IDA, PMID:15546903); GO_0070989 (EC: IDA, PMID:15039299)
PMID:1391968; 2463251; 2492107; 3243766; 3259858; 3267210; 3460094; 3464943; 3898085; 8269949; 9088578; 9394023; 9456308; 9890157; 10222036; 10322772; 10668853; 10933049; 11051261; 11067821; 11137287; 11161840; 11181494; 11266076; 11470997; 11549683; 11714865; 11726664; 11745731; 11749050; 11782366; 11809184; 11875366; 11876753; 11890939; 11907494; 11940601; 11956645; 11991950; 12072427; 12107441; 12130689; 12142725; 12147248; 12151999; 12202670; 12419838; 12439220; 12446983; 12464248; 12477932; 12485945; 12493773; 12532467; 12569554; 12623762; 12644831; 12690205; 12692107; 12695546; 12732844; 12738724; 12747609; 12756206; 12756210; 12809821; 12867495; 12900870; 12900872; 12960109; 12966368; 12969965; 12975335; 14504207; 14515058; 14515059; 14580164; 14640293; 14643022; 14660173; 14681232; 14690448; 14693733; 14697480; 14742674; 15039299; 15114431; 15128046; 15256616; 15258162; 15260917; 15277015; 15307840; 15319333; 15327587; 15334674; 15365656; 15370963; 15379787; 15454728; 15459178; 15462611; 15469410; 15475069; 15496535; 15496639; 15523087; 15540736; 15546903; 15548719; 15592326; 15611481; 15618745; 15622315; 15634941; 15650881; 15680923; 15684873; 15698606; 15707415; 15708356; 15708542; 15713537; 15731117; 15770073; 15770075; 15778453; 15801936; 15817670; 15820320; 15882469; 15896485; 15900215; 15900284; 15901749; 15931768; 15932952; 15981231; 16004554; 16006997; 16059671; 16079101; 16103451; 16109480; 16130011; 16146556; 16172230; 16207150; 16243813; 16267764; 16299241; 16306861; 16314882; 16321621; 16324277; 16338276; 16344560; 16401082; 16414488; 16434211; 16467307; 16507515; 16538176; 16580902; 16608838; 16633141; 16645157; 16684709; 16711396; 16758258; 16765145; 16771603; 16842392; 16862439; 16890574; 16890579; 16906020; 16909599; 16924387; 16954191; 16981844; 16985250; 17007050; 17014074; 17015051; 17042920; 17047492; 17065585; 17083953; 17118447; 17119944; 17162468; 17178267; 17200113; 17220347; 17224914; 17270371; 17279585; 17296590; 17352764; 17357589; 17363580; 17364054; 17367411; 17372239; 17373732; 17392393; 17409981; 17418993; 17429319; 17433262; 17434921; 17460031; 17460547; 17465708; 17495874; 17495878; 17495880; 17498886; 17502835; 17526062; 17526937; 17545536; 17548528; 17548691; 17555301; 17582393; 17601520; 17605821; 17609736; 17615053; 17622974; 17624028; 17634410; 17635182; 17691855; 17697139; 17701008; 17704997; 17724065; 17764444; 17766366; 17827338; 17827444; 17854673; 17880367; 17900275; 17912464; 17918187; 17919092; 17919884; 17922881; 17925385; 17925548; 17952011; 17965521; 17974099; 17985934; 17992531; 18004209; 18004210; 18021343; 18028890; 18052847; 18058330; 18092806; 18097620; 18163429; 18192894; 18211048; 18217151; 18223457; 18231117; 18240903; 18258609; 18268015; 18294295; 18294936; 18309947; 18332045; 18348473; 18356043; 18364084; 18382661; 18385010; 18394438; 18408564; 18431572; 18433425; 18446064; 18496131; 18509327; 18518855; 18528690; 18551040; 18566991; 18569587; 18619574; 18632753; 18636247; 18669585; 18688081; 18704002; 18768784; 18781853; 18784074; 18794335; 18825162; 18854779; 18936436; 18957504; 18976975; 18978522; 18979093; 18981009; 18981011; 18989234; 18996102; 19005401; 19020497; 19027952; 19064572; 19070657; 19074750; 19076156; 19077426; 19103148; 19127255; 19143748; 19206087; 19214745; 19219744; 19225447; 19228205; 19228751; 19232333; 19239339; 19242060; 19258929; 19282874; 19332043; 19337788; 19339270; 19343046; 19343062; 19343327; 19349540; 19350405; 19356113; 19376514; 19395426; 19406954; 19414505; 19420105; 19424794; 19433561; 19451401; 19453261; 19460945; 19470925; 19474452; 19480557; 19505920; 19506580; 19538885; 19546880; 19560436; 19571438; 19574343; 19575027; 19576320; 19591893; 19626470; 19636001; 19651758; 19659438; 19667110; 19692168; 19696793; 19712670; 19727863; 19752211; 19761365; 19762492; 19773538; 19784640; 19797609; 19801957; 19802823; 19812066; 19823875; 19833260; 19842932; 19846565; 19865079; 19907160; 19913121; 19921206; 19926050; 19934400; 19934793; 19937844; 19956635; 19963139; 20007670; 20012430; 20017669; 20027111; 20031551; 20038391; 20068078; 20088394; 20118548; 20136364; 20147837; 20147896; 20171174; 20173083; 20212519; 20213484; 20214802; 20218903; 20235787; 20338069; 20350051; 20350136; 20354687; 20361990; 20386561; 20389299; 20395213; 20403997; 20437850; 20453000; 20459744; 20490798; 20505544; 20523106; 20526235; 20529763; 20530282; 20538049; 20538721; 20578904; 20583967; 20588308; 20602612; 20602615; 20604570; 20615193; 20617557; 20621111; 20625352; 20628086; 20630055; 20634197; 20642445; 20654748; 20656072; 20679960; 20682687; 20697309; 20715157; 20734064; 20809279; 20812728; 20833683; 20841961; 20847137; 20849814; 20861742; 20863320; 20879989; 20884258; 20931330; 20951982; 20959500; 20970553; 21047202; 21063236; 21071160; 21072155; 21072184; 21081028; 21081644; 21114969; 21169260; 21177853; 21186373; 21199372; 21207936; 21209460; 21223952; 21292004; 21342487; 21380731; 21402137; 21402692; 21412247; 21433154; 21471209; 21493872; 21513075; 21566342; 21605066; 21692828; 21750466; 21767526; 21798277; 21835977; 21838784; 21863748; 21886157; 21902501; 21902502; 21903774; 21916909; 21925256; 21940338; 21952236; 21963990; 21964586; 21988832; 21992114; 21996064; 21998292; 22050110; 22076448; 22094027; 22096084; 22101235; 22106171; 22108774; 22157006; 22194603; 22277676; 22292071; 22333269; 22369694; 22388796; 22472546; 22510778; 22517972; 22562045; 22617232; 22621802; 22645092; 22677141; 22696420; 22699155; 22728071; 22741198; 22763214; 22773874; 22885098; 22906825; 22945461; 22971138; 22985909; 22990330; 22993851; 23090875; 23107770; 23129512; 23143891; 23146479; 23160340; 23162896; 23179402; 23212742; 23217392; 23223499; 23252948; 23264496; 23277250; 23290512; 23295386; 23313934; 23320986; 23334403; 23361102; 23400261; 23436703; 23459029; 23469989; 23491640; 23510058; 23527115; 23530020; 23557865; 23574760; 23640974; 23665933; 23715232; 23732298; 23746300; 23780963; 23837477; 23965431; 23977680; 24256945; 24273886
cytochrome P450, family 3, subfamily A, polypeptide 4
HGNC:2637
HPRD:00484
MIM:124010
Other designations: 1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase|albendazole sulfoxidase|cytochrome P450 3A3|cytochrome P450 3A4|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase
CYP3A4
Bin Zhao, Yue Liu, Oliver He
CP35
CYPIIIA5
P450PCN3
PCN3
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 5
1577
7q21.1
9606
7
GO_0004497 (EC: ISS); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS, PMID:2732228); GO_0009822 (EC: IDA, PMID:15039299); GO_0016491 (EC: IDA, PMID:15039299); GO_0019825 (EC: TAS, PMID:2732228); GO_0020037 (EC: IEA); GO_0042737 (EC: IDA, PMID:15039299); GO_0043231 (EC: TAS, PMID:2732228); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA); GO_0070989 (EC: IDA, PMID:15039299)
PMID:2732228; 2802615; 7750548; 7811260; 7883227; 7894497; 7895614; 8004129; 8125298; 8569713; 8619878; 8619884; 8694864; 8869826; 8877031; 8889549; 8946469; 9070608; 9364212; 9797707; 9890157; 10069460; 10403825; 11137287; 11266076; 11279519; 11502729; 11726664; 11740341; 11809184; 11836601; 12042671; 12202670; 12242601; 12324482; 12433824; 12439220; 12477932; 12690205; 12692107; 12694732; 12754175; 12756511; 12814460; 12822676; 12853948; 12893984; 12960109; 12966368; 12969965; 12975492; 14504207; 14515058; 14515059; 14647405; 14676821; 14702039; 14747421; 14961555; 15039299; 15114431; 15116055; 15128046; 15167702; 15226679; 15248218; 15252010; 15284534; 15289787; 15319333; 15385835; 15454734; 15469410; 15489334; 15502717; 15548719; 15592326; 15596297; 15596575; 15622315; 15632378; 15634941; 15698606; 15707415; 15708542; 15729180; 15801936; 15808586; 15814280; 15833928; 15876487; 15882469; 15900215; 15900284; 15919447; 15931768; 15952872; 15961978; 15978331; 15981231; 16004554; 16024008; 16086282; 16116487; 16141800; 16160620; 16168193; 16172230; 16188140; 16207150; 16243813; 16249748; 16253141; 16267764; 16272171; 16272955; 16299241; 16306861; 16314882; 16321621; 16338276; 16361630; 16421475; 16424824; 16442753; 16513443; 16584389; 16595916; 16612255; 16612333; 16614106; 16628701; 16638864; 16684709; 16765145; 16765147; 16769602; 16771603; 16772608; 16791115; 16815317; 16822233; 16827636; 16842392; 16847425; 16906018; 16906020; 17015051; 17032130; 17042920; 17047492; 17048977; 17049058; 17049128; 17162466; 17178265; 17178267; 17192506; 17192769; 17198275; 17224914; 17244352; 17264302; 17286792; 17296590; 17329995; 17339868; 17352764; 17358097; 17363580; 17372036; 17373732; 17377957; 17391324; 17395652; 17425754; 17430486; 17443134; 17450472; 17460031; 17495880; 17495881; 17502835; 17510208; 17517050; 17545536; 17554244; 17568575; 17582393; 17605821; 17615053; 17635176; 17635181; 17635182; 17691921; 17700595; 17701008; 17761709; 17827141; 17851225; 17875118; 17885626; 17900275; 17914095; 17922881; 17925548; 17941052; 17979504; 17979523; 17992026; 18021343; 18024866; 18028890; 18058330; 18192894; 18211618; 18212618; 18214455; 18221820; 18223457; 18240903; 18248681; 18294295; 18300941; 18306354; 18309947; 18315786; 18315894; 18319058; 18322448; 18334918; 18382661; 18385010; 18385991; 18394438; 18408564; 18414696; 18429967; 18443548; 18490434; 18496128; 18496131; 18502461; 18509327; 18509328; 18509645; 18518855; 18551040; 18566991; 18582803; 18587567; 18589174; 18597650; 18603015; 18628519; 18636247; 18641551; 18650247; 18688081; 18704002; 18708991; 18727922; 18752284; 18930278; 18936931; 18978522; 18979093; 18981009; 18989234; 18996102; 19005401; 19005461; 19010156; 19033450; 19034006; 19040121; 19064572; 19067682; 19074750; 19076156; 19106083; 19106084; 19114346; 19125240; 19139162; 19141860; 19205682; 19225447; 19228205; 19228751; 19229255; 19239339; 19258929; 19289993; 19290787; 19290795; 19332043; 19337788; 19343046; 19343327; 19349540; 19350405; 19376366; 19376514; 19384171; 19384264; 19414505; 19414633; 19424794; 19470925; 19474452; 19506580; 19516253; 19523815; 19538885; 19545678; 19546880; 19576320; 19584153; 19591893; 19593168; 19636001; 19644155; 19650988; 19659438; 19663817; 19667110; 19693007; 19696793; 19710077; 19730841; 19744012; 19761365; 19762492; 19801957; 19812606; 19817997; 19823770; 19842932; 19855314; 19865079; 19881258; 19904021; 19907160; 19913121; 19916993; 19925383; 19934793; 19946748; 20010459; 20017669; 20030680; 20031551; 20038391; 20040338; 20041908; 20118548; 20133509; 20136364; 20147896; 20160155; 20172323; 20173083; 20179710; 20207952; 20212519; 20214802; 20218903; 20231858; 20235787; 20332423; 20345875; 20354687; 20357698; 20368718; 20383212; 20389299; 20393454; 20395213; 20403997; 20415563; 20430047; 20453000; 20459744; 20479955; 20490798; 20514078; 20526235; 20529763; 20530282; 20565970; 20588203; 20596503; 20602615; 20615193; 20617557; 20621111; 20625352; 20628086; 20630055; 20662624; 20679960; 20696882; 20716514; 20720558; 20818295; 20833683; 20846929; 20860463; 20873239; 20881953; 20931330; 20959405; 20959500; 20970553; 20970601; 20970628; 20970643; 21039054; 21047202; 21072155; 21072184; 21076384; 21081028; 21094057; 21094796; 21094797; 21148251; 21153923; 21165655; 21173786; 21206424; 21209234; 21225912; 21237140; 21265876; 21380731; 21389905; 21418106; 21434577; 21436775; 21493872; 21513075; 21519338; 21544031; 21644845; 21677300; 21698374; 21711429; 21743379; 21770725; 21806386; 21814220; 21839244; 21851254; 21896346; 21916909; 21950641; 21988832; 22007612; 22022918; 22096084; 22210422; 22214815; 22277678; 22292071; 22304537; 22369694; 22511346; 22610055; 22645092; 22696420; 22704849; 22819265; 22875663; 22889968; 22923690; 22993851; 23023417; 23073208; 23107770; 23131698; 23143606; 23143891; 23146466; 23146479; 23149441; 23223499; 23320986; 23354298; 23364483; 23385102; 23432535; 23459029; 23491640; 23557865; 23584898; 23633119; 23700791; 23715232; 23723360; 23734777; 23780963; 23837476; 23845965; 23873120; 23984379
cytochrome P450, family 3, subfamily A, polypeptide 5
Ensembl:ENSG00000106258
HGNC:2638
HPRD:05617
MIM:605325
Vega:OTTHUMG00000156724
Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 3A5|cytochrome P450 HLp2|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5|cytochrome P450-PCN3|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
CYP3A5
Bin Zhao, Yue Liu, Oliver He
CP4Y
CYP4A2
CYP4AII
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
1579
1p33
9606
1
GO_0001676 (EC: IDA, PMID:18433732); GO_0003091 (EC: IEP, PMID:10660572); GO_0003095 (EC: IEP, PMID:10660572); GO_0005506 (EC: IEA); GO_0005737 (EC: IDA, PMID:10660572); GO_0005789 (EC: TAS); GO_0006631 (EC: TAS, PMID:7679927); GO_0006691 (EC: IDA, PMID:9799565); GO_0006805 (EC: TAS); GO_0008392 (EC: IDA, PMID:9618440); GO_0016324 (EC: IDA, PMID:10660572); GO_0018685 (EC: IDA, PMID:18433732); GO_0019369 (EC: IDA, PMID:10660572); GO_0019369 (EC: TAS); GO_0019373 (EC: IDA, PMID:9618440); GO_0020037 (EC: IEA); GO_0032305 (EC: IMP, PMID:18391101); GO_0036101 (EC: IDA, PMID:9799565); GO_0043231 (EC: IDA, PMID:10660572); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0050051 (EC: IDA, PMID:9799565); GO_0052869 (EC: IEA); GO_0055078 (EC: IEP, PMID:10660572); GO_0055114 (EC: IDA, PMID:18433732); GO_0097267 (EC: TAS)
PMID:1739747; 7679927; 7798189; 8274222; 8363569; 8914854; 9618440; 9799565; 10024026; 10660572; 10860550; 11139583; 11736898; 11821421; 12464261; 12464262; 12477932; 15028279; 15128046; 15319333; 15611369; 16144986; 16957555; 18227405; 18300855; 18385420; 18391101; 18433732; 18484194; 18574070; 18624398; 18660489; 18936345; 19343046; 19366684; 19615687; 19898482; 20130494; 21326303; 21617944; 21820496; 21873888; 21886157; 21912424; 22327816; 22804341; 23085321
cytochrome P450, family 4, subfamily A, polypeptide 11
Ensembl:ENSG00000187048
HGNC:2642
HPRD:03201
MIM:601310
Vega:OTTHUMG00000008020
Other designations: 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVA11|P450HL-omega|alkane-1 monooxygenase|cytochrome P-450HK-omega|cytochrome P450 4A11|cytochrome P450, subfamily IVA, polypeptide 11|cytochrome P450HL-omega|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase
CYP4A11
Bin Zhao, Yue Liu, Oliver He
CYPIVB1
P-450HP
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
1580
RP4-732G19.1
1p33
9606
1
GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006805 (EC: TAS); GO_0008144 (EC: IEA); GO_0018585 (EC: IEA); GO_0018879 (EC: IEA); GO_0018917 (EC: IEA); GO_0019825 (EC: TAS, PMID:2574990); GO_0020037 (EC: IEA); GO_0042738 (EC: IEA); GO_0044281 (EC: TAS); GO_0070330 (EC: IEA)
PMID:2298205; 2574990; 7894498; 8125298; 8313365; 8694864; 8889548; 9202751; 9364212; 9493761; 9498238; 10768437; 11062028; 11669629; 11737226; 11767004; 12142726; 12477932; 12837283; 15006160; 15128046; 15499177; 16344560; 18660489; 18713828; 19040121; 19074885; 19343046; 19898482; 19913121; 20379614; 20628086; 22675492
cytochrome P450, family 4, subfamily B, polypeptide 1
Ensembl:ENSG00000142973
HGNC:2644
HPRD:00491
MIM:124075
Vega:OTTHUMG00000007984
Other designations: cytochrome P450 4B1|cytochrome P450, subfamily IVB, polypeptide 1|cytochrome P450-HP|microsomal monooxygenase
CYP4B1
CP7A
CYP7
CYPVII
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
1581
8q11-q12
9606
8
GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006699 (EC: IDA, PMID:19965590); GO_0006699 (EC: IEA); GO_0006699 (EC: ISS); GO_0006699 (EC: TAS); GO_0006707 (EC: ISS); GO_0006805 (EC: TAS); GO_0008123 (EC: ISS); GO_0008206 (EC: TAS); GO_0016125 (EC: TAS); GO_0020037 (EC: IEA); GO_0042632 (EC: ISS); GO_0043231 (EC: ISS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0070857 (EC: IDA, PMID:19965590); GO_0070857 (EC: ISS); GO_0071333 (EC: IDA, PMID:19965590); GO_0071397 (EC: ISS)
PMID:1312351; 1358792; 1610352; 2384150; 7288293; 8020987; 8439551; 8504159; 9559267; 10359768; 10882719; 11257258; 11907135; 12011083; 12093884; 12093894; 12116231; 12202481; 12213890; 12477932; 12554795; 12721789; 12810154; 12815072; 12865425; 14515446; 14522988; 14592954; 14762172; 15128046; 15133863; 15205472; 15241483; 15262185; 15333704; 15489334; 15640003; 15707388; 15736936; 15752749; 15796896; 15805302; 15910869; 16115473; 16630139; 16709249; 16763159; 16892178; 16917677; 16937432; 17680536; 17920062; 18078817; 18178499; 18270374; 18307386; 18385139; 18660489; 18665040; 18728123; 18728290; 18996102; 19018779; 19185005; 19343046; 19448895; 19463968; 19537927; 19558216; 19598235; 19850125; 19956635; 19965590; 20005541; 20031551; 20235787; 20351063; 20403997; 20578904; 20602615; 20686565; 20717043; 20857261; 20872969; 20884100; 21039385; 21147774; 21346769; 21813643; 21902813; 22058145; 22235657; 22607622; 22713451; 23038264; 23458092; 23626788
cytochrome P450, family 7, subfamily A, polypeptide 1
Ensembl:ENSG00000167910
HGNC:2651
HPRD:00324
MIM:118455
Vega:OTTHUMG00000164301
Other designations: cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1
CYP7A1
Bin Zhao, Yue Liu, Oliver He
CP8B
CYP12
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
1582
3p22.1
9606
3
GO_0005506 (EC: IEA); GO_0005783 (EC: IBA); GO_0005789 (EC: TAS); GO_0006629 (EC: IBA); GO_0006699 (EC: TAS); GO_0006805 (EC: TAS); GO_0008206 (EC: TAS); GO_0008397 (EC: IBA); GO_0016021 (EC: IEA); GO_0016125 (EC: TAS); GO_0019825 (EC: TAS, PMID:10051404); GO_0020037 (EC: IBA); GO_0033778 (EC: IEA); GO_0044281 (EC: TAS)
PMID:10051404; 11535594; 12477932; 15128046; 15249218; 15489334; 15891895; 16937432; 17585019; 18660489; 19898482; 22093981; 23216301; 24226095
cytochrome P450, family 8, subfamily B, polypeptide 1
Ensembl:ENSG00000180432
HGNC:2653
HPRD:03705
MIM:602172
Vega:OTTHUMG00000133047
Other designations: 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
CYP8B1
Bin Zhao, Yue Liu, Oliver He
CYP11A
CYPXIA1
P450SCC
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
1583
15q23-q24
9606
15
GO_0005506 (EC: IEA); GO_0005739 (EC: ISS); GO_0005759 (EC: TAS); GO_0006700 (EC: IDA, PMID:11502818); GO_0006700 (EC: TAS); GO_0006701 (EC: IEA); GO_0006703 (EC: IEA); GO_0006805 (EC: TAS); GO_0007617 (EC: IEA); GO_0008202 (EC: TAS); GO_0008203 (EC: IDA); GO_0008203 (EC: IMP, PMID:18182448); GO_0008203 (EC: ISS); GO_0008386 (EC: IDA, PMID:11502818); GO_0008386 (EC: ISS); GO_0009651 (EC: IEA); GO_0010332 (EC: IEA); GO_0014037 (EC: IEA); GO_0015485 (EC: IEA); GO_0016125 (EC: TAS); GO_0017085 (EC: IEA); GO_0018879 (EC: IEA); GO_0018894 (EC: IEA); GO_0018958 (EC: IEA); GO_0018963 (EC: IEA); GO_0020037 (EC: IDA); GO_0021549 (EC: IEA); GO_0021766 (EC: IEA); GO_0030061 (EC: IEA); GO_0033197 (EC: IEA); GO_0033327 (EC: IEA); GO_0033591 (EC: IEA); GO_0033595 (EC: IEA); GO_0042359 (EC: ISS); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0043204 (EC: IEA); GO_0043279 (EC: IEA); GO_0044281 (EC: TAS); GO_0044344 (EC: IEA); GO_0050756 (EC: IEA); GO_0051412 (EC: IEA); GO_0060014 (EC: IEA); GO_0060135 (EC: IEA); GO_0060992 (EC: IEA); GO_0061370 (EC: IEA); GO_0071222 (EC: IEA); GO_0071236 (EC: IEA); GO_0071276 (EC: IEA); GO_0071320 (EC: IEA); GO_0071347 (EC: IEA); GO_0071356 (EC: IEA); GO_0071372 (EC: IEA); GO_0071375 (EC: IEA); GO_0071560 (EC: IEA)
PMID:1429635; 1849407; 1863359; 1917982; 2419119; 3024157; 3038854; 8125298; 8372604; 9029710; 9147642; 9498238; 9685215; 10391209; 10411633; 10416690; 10644752; 10856721; 11008920; 11062177; 11137199; 11238527; 11502818; 11535251; 11701663; 11864972; 11997174; 12101186; 12137805; 12145340; 12161514; 12242026; 12385014; 12477932; 12517592; 12530663; 12530676; 14644808; 14702039; 15054879; 15126571; 15128046; 15159300; 15231748; 15323426; 15471945; 15489334; 15583024; 15613430; 15793791; 15927889; 16103457; 16116976; 16172228; 16195240; 16344560; 16391898; 16409859; 16764871; 16798289; 17065579; 17110639; 17178901; 17507624; 17575134; 17594537; 17615053; 18004979; 18182448; 18191841; 18307388; 18368131; 18437511; 18483327; 18490834; 18499961; 18505908; 18665078; 18725155; 18992638; 19064571; 19116240; 19197249; 19240061; 19300392; 19336370; 19342447; 19453261; 19543524; 19574343; 19598235; 19846611; 20066577; 20199803; 20200332; 20214802; 20381444; 20450755; 20634197; 20734064; 20877624; 21159840; 21164259; 21195129; 21391350; 21520051; 21557918; 21636783; 21771722; 21880796; 22199361; 22227097; 22585829; 22673022; 22699877; 22877869; 23158025; 23330251; 23337730; 23555723; 23756599
cytochrome P450, family 11, subfamily A, polypeptide 1
Ensembl:ENSG00000140459
HGNC:2590
HPRD:00326
MIM:118485
Vega:OTTHUMG00000150716
Other designations: cholesterol 20-22 desmolase|cholesterol monooxygenase (side-chain cleaving)|cholesterol side-chain cleavage enzyme, mitochondrial|cytochrome P450 11A1|cytochrome P450(scc)|cytochrome P450, subfamily XIA (cholesterol side chain cleavage)|cytochrome P450C11A1|steroid 20-22-lyase
CYP11A1
Bin Zhao, Yue Liu, Oliver He
CPN1
CYP11B
FHI
P450C11
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
1584
8q21
9606
8
GO_0004507 (EC: IDA, PMID:2256920); GO_0004507 (EC: IMP, PMID:2022736); GO_0005506 (EC: IEA); GO_0005739 (EC: IDA, PMID:2256920); GO_0005743 (EC: IC, PMID:8506298); GO_0005743 (EC: TAS, PMID:15026188); GO_0006700 (EC: IDA, PMID:2256920); GO_0006704 (EC: TAS); GO_0006705 (EC: TAS); GO_0006805 (EC: TAS); GO_0006955 (EC: TAS, PMID:12452430); GO_0008202 (EC: TAS); GO_0008217 (EC: IMP, PMID:2022736); GO_0016125 (EC: TAS); GO_0020037 (EC: IC, PMID:2256920); GO_0032342 (EC: IDA, PMID:2256920); GO_0032342 (EC: IMP, PMID:19342457); GO_0032870 (EC: IEP, PMID:19342457); GO_0034651 (EC: IDA, PMID:8506298); GO_0034651 (EC: IMP, PMID:19342457); GO_0035865 (EC: IEP, PMID:19342457); GO_0042593 (EC: TAS, PMID:16114325); GO_0044281 (EC: TAS)
PMID:1303253; 1430088; 1518866; 1741400; 2022736; 2256920; 2401360; 2592361; 3499608; 7903314; 8372604; 8506298; 9302260; 10391209; 10391210; 10411633; 10599751; 11095433; 11549669; 11549691; 11675945; 11903322; 11932209; 12452430; 12477932; 14682466; 14702039; 15026188; 15062555; 15128046; 15324322; 15507509; 15522937; 15583024; 15699546; 15751602; 15755848; 15793791; 16030166; 16110193; 16114325; 16396990; 16984984; 17075029; 17121536; 17296872; 17556864; 17651452; 17980006; 18215163; 18294861; 18397978; 18636124; 18661760; 18663314; 18974272; 19082699; 19336370; 19342457; 19453261; 19567537; 19598235; 19820005; 19844114; 19913121; 20089618; 20214802; 20331679; 20339375; 20486282; 20523022; 20529578; 20628086; 20634641; 20708777; 20808686; 20877624; 20947076; 21164264; 21625068; 21848792; 22083159; 22217843; 22921894; 22964742; 23146819; 23150505; 23345044; 23825130
cytochrome P450, family 11, subfamily B, polypeptide 1
Ensembl:ENSG00000160882
HGNC:2591
HPRD:01943
MIM:610613
Vega:OTTHUMG00000164637
Other designations: CYPXIB1|cytochrome P-450c11|cytochrome P450 11B1, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1|cytochrome P450C11|cytochrome p450 XIB1|steroid 11-beta-hydroxylase|steroid 11-beta-monooxygenase
CYP11B1
Bin Zhao, Yue Liu, Oliver He
ALDOS
CPN2
CYP11B
CYP11BL
CYPXIB2
P-450C18
P450C18
P450aldo
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
1585
8q21-q22
9606
8
GO_0002017 (EC: IMP, PMID:14614232); GO_0003091 (EC: IC, PMID:2256920); GO_0004507 (EC: IDA, PMID:1741400); GO_0005506 (EC: IEA); GO_0005739 (EC: IDA, PMID:1741400); GO_0005743 (EC: IC, PMID:2256920); GO_0005743 (EC: TAS); GO_0006700 (EC: IDA, PMID:2256920); GO_0006705 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS); GO_0016125 (EC: TAS); GO_0020037 (EC: IC, PMID:2256920); GO_0020037 (EC: IDA); GO_0032342 (EC: IDA, PMID:1741400); GO_0032342 (EC: IMP, PMID:19342457); GO_0032870 (EC: IEP, PMID:19342457); GO_0034651 (EC: IMP, PMID:19342457); GO_0034651 (EC: IMP, Qualifier: NOT, PMID:9703385); GO_0035865 (EC: IEP, PMID:19342457); GO_0044281 (EC: TAS); GO_0047783 (EC: IEA); GO_0055075 (EC: IMP, PMID:9838244); GO_0055078 (EC: IMP, PMID:9838244)
PMID:1303253; 1346492; 1518866; 1594605; 1741400; 1775135; 2256920; 2592361; 3872685; 7792802; 8372604; 8439335; 8954040; 9177280; 9360501; 9506770; 9625333; 9703385; 9814506; 9838244; 9931115; 10371693; 10391209; 10391210; 10411633; 10902803; 11076863; 11116113; 11238478; 11245725; 11288810; 11325068; 11422106; 11422735; 11447495; 11518842; 11587161; 11696658; 11696688; 11711521; 11711524; 11725161; 11728005; 11728946; 11841224; 11856349; 11903322; 11910301; 11923700; 11932209; 11967817; 12022239; 12031704; 12065207; 12107246; 12133420; 12137808; 12161536; 12172317; 12193581; 12195120; 12205735; 12213905; 12376254; 12391843; 12444540; 12446192; 12446468; 12477932; 12544440; 12544508; 12611423; 12624609; 12627873; 12746403; 12783697; 12788845; 12788848; 12817181; 12832734; 14508191; 14530292; 14614232; 14643573; 14704730; 14736447; 15055249; 15062555; 15097233; 15102677; 15128046; 15135254; 15223724; 15230231; 15238568; 15272911; 15361760; 15378162; 15479186; 15505931; 15507509; 15522937; 15532370; 15545843; 15569322; 15573760; 15583024; 15583997; 15600184; 15611122; 15614025; 15643128; 15662219; 15699546; 15824464; 15882548; 15894890; 15894891; 15914614; 16078594; 16080804; 16080805; 16110193; 16126185; 16207322; 16208140; 16303227; 16396990; 16468060; 16485730; 16580565; 16615274; 16638864; 16672053; 16714246; 16759311; 16765146; 16767667; 16780672; 16796847; 16893516; 16979018; 16984984; 17003099; 17075029; 17143166; 17190732; 17261471; 17273158; 17296872; 17318792; 17334527; 17334644; 17383306; 17407071; 17519002; 17531119; 17546276; 17631084; 17633457; 17651452; 17664852; 17698557; 17762647; 17851694; 17980006; 17984617; 17987391; 18192839; 18202594; 18260840; 18260994; 18397978; 18413308; 18446309; 18636124; 18638595; 18660489; 18710464; 18771471; 18773126; 18855530; 18856058; 18974272; 19026620; 19093739; 19112833; 19116236; 19117407; 19151144; 19158234; 19166692; 19243623; 19253715; 19254215; 19262476; 19332265; 19342457; 19343046; 19407459; 19418629; 19609286; 19729965; 19776632; 19779464; 19786005; 19820005; 19853701; 19913121; 19948975; 19956635; 20094057; 20097716; 20123934; 20176774; 20182453; 20193236; 20193392; 20214802; 20224556; 20300066; 20339375; 20381197; 20413672; 20416077; 20486282; 20494601; 20535141; 20537417; 20560800; 20598712; 20628086; 20634641; 20659024; 20662731; 20708777; 20808686; 20831027; 20877624; 20878543; 20966514; 21092623; 21106862; 21125974; 21127960; 21163122; 21164264; 21228735; 21239432; 21269059; 21357309; 21476902; 21625068; 21682760; 21777344; 21846681; 22083159; 22134143; 22156739; 22217843; 22311496; 22331364; 22508051; 22652909; 22801770; 22885098; 23023242; 23133610; 23135028; 23150505; 23209837; 23257735; 23275203; 23322723; 23443813; 23479071; 23535359; 23701507; 23936266; 24015270
cytochrome P450, family 11, subfamily B, polypeptide 2
Ensembl:ENSG00000179142
HGNC:2592
HPRD:00492
MIM:124080
Vega:OTTHUMG00000160254
Other designations: aldosterone synthase|aldosterone-synthesizing enzyme|cytochrome P-450Aldo|cytochrome P-450C18|cytochrome P450 11B2, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2|mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2|steroid 11-beta-monooxygenase|steroid 11-beta/18-hydroxylase|steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
CYP11B2
Bin Zhao, Yue Liu, Oliver He
CPT7
CYP17
P450C17
S17AH
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
1586
RP11-753C18.1
10q24.3
9606
10
GO_0004508 (EC: IDA); GO_0005506 (EC: IEA); GO_0005739 (EC: IEA); GO_0005783 (EC: NAS, PMID:9326943); GO_0005789 (EC: TAS); GO_0006694 (EC: TAS, PMID:3500022); GO_0006702 (EC: TAS); GO_0006704 (EC: TAS); GO_0006805 (EC: TAS); GO_0007548 (EC: TAS, PMID:9326943); GO_0008202 (EC: IDA); GO_0008202 (EC: TAS); GO_0009635 (EC: IEA); GO_0010034 (EC: IEA); GO_0010212 (EC: IEA); GO_0016125 (EC: TAS); GO_0017085 (EC: IEA); GO_0018879 (EC: IEA); GO_0018894 (EC: IEA); GO_0018958 (EC: IEA); GO_0018963 (EC: IEA); GO_0019825 (EC: TAS, PMID:2808364); GO_0020037 (EC: IDA); GO_0021766 (EC: IEA); GO_0030325 (EC: IEA); GO_0030424 (EC: IEA); GO_0030728 (EC: IEA); GO_0031667 (EC: IEA); GO_0032526 (EC: IEA); GO_0033327 (EC: IEA); GO_0034097 (EC: IEA); GO_0042446 (EC: IDA); GO_0042448 (EC: IDA); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0044281 (EC: TAS); GO_0047442 (EC: IEA); GO_0048545 (EC: IEA); GO_0051591 (EC: IEA); GO_0051597 (EC: IEA); GO_0060992 (EC: IEA); GO_0071222 (EC: IEA); GO_0071236 (EC: IEA); GO_0071371 (EC: IEA); GO_0090031 (EC: IEA)
PMID:1347802; 1478654; 1515452; 1577471; 1621662; 1665206; 1714904; 1740503; 1964490; 2335573; 2466376; 2786493; 2808364; 2843762; 3025870; 3274893; 3488328; 3500022; 6976525; 7629254; 8027220; 8245018; 8345056; 8396144; 8550762; 8675607; 8855840; 9177409; 9326943; 9360545; 9435441; 9601054; 9888582; 10406467; 10720067; 11036113; 11059764; 11094312; 11142420; 11145739; 11212283; 11221867; 11232039; 11248649; 11303586; 11341336; 11358812; 11379008; 11440959; 11470993; 11535545; 11549685; 11571725; 11668516; 11749050; 11834432; 11836339; 11839369; 11847524; 11867265; 11880540; 11888844; 11895872; 11897684; 11911969; 11925378; 11956159; 12036913; 12036914; 12164325; 12368392; 12370109; 12385014; 12444089; 12446594; 12464252; 12466376; 12477932; 12506119; 12517592; 12530262; 12530647; 12530662; 12530676; 12574216; 12582021; 12584742; 12602902; 12631293; 12631398; 12644832; 12645864; 12652520; 12692107; 12718576; 12719950; 12949806; 12954495; 12971967; 14504283; 14512432; 14552332; 14552333; 14561815; 14575568; 14634838; 14644808; 14665706; 14671162; 14684846; 14693733; 14702039; 14714492; 14715870; 14744739; 14985252; 14995917; 15072828; 15128046; 15129369; 15164054; 15195127; 15199113; 15235815; 15241822; 15341023; 15364798; 15372520; 15382051; 15466495; 15477877; 15482786; 15489334; 15536258; 15538743; 15539439; 15555906; 15583024; 15591802; 15598676; 15604994; 15609124; 15654505; 15663233; 15686129; 15687493; 15706422; 15711606; 15749482; 15761247; 15774541; 15799583; 15823822; 15824149; 15865082; 15878919; 15886251; 15916684; 15927351; 15941966; 15953542; 15987450; 15987458; 15999490; 16045239; 16202920; 16214922; 16232327; 16244490; 16260521; 16280037; 16306078; 16319265; 16344560; 16354159; 16381022; 16385451; 16411751; 16424004; 16515644; 16519145; 16527884; 16595228; 16595705; 16603433; 16604478; 16608396; 16616104; 16638864; 16702327; 16707883; 16716118; 16720291; 16730930; 16739881; 16782804; 16783967; 16850246; 16859836; 16875543; 16885156; 16887917; 16890174; 16896040; 16909599; 16969494; 16971197; 16977255; 17077994; 17108148; 17110639; 17119038; 17167982; 17218734; 17235448; 17307805; 17328668; 17359589; 17386955; 17484509; 17507624; 17588204; 17589376; 17606708; 17615053; 17664281; 17669147; 17704407; 17760252; 17765230; 17785571; 17786540; 17826473; 17875358; 17895316; 17961073; 17975119; 17986287; 18000308; 18006912; 18163429; 18172694; 18184656; 18187541; 18262808; 18281250; 18299473; 18305346; 18318428; 18411914; 18415690; 18422032; 18437511; 18483327; 18491956; 18495332; 18496127; 18499961; 18501301; 18503826; 18505908; 18510611; 18560445; 18593984; 18601603; 18618215; 18619494; 18629629; 18636124; 18636181; 18645709; 18676680; 18682255; 18707589; 18722876; 18725155; 18767927; 18781485; 18820009; 18930188; 18957719; 18980759; 19013303; 19015200; 19023099; 19064572; 19064581; 19127255; 19170196; 19174490; 19267349; 19330259; 19336370; 19379515; 19387820; 19415745; 19430479; 19430483; 19443382; 19453261; 19454579; 19469636; 19505920; 19508587; 19574343; 19598235; 19625176; 19627379; 19636199; 19642097; 19672705; 19692168; 19789190; 19805543; 19850690; 19863350; 19913121; 19915575; 19954068; 19956635; 20013047; 20033766; 20043206; 20043997; 20069306; 20072949; 20086173; 20099974; 20113968; 20133979; 20171624; 20173016; 20184498; 20193327; 20197673; 20200332; 20207836; 20214802; 20379614; 20381444; 20414254; 20432167; 20453000; 20479155; 20503394; 20534731; 20539301; 20595043; 20619364; 20628086; 20628746; 20634197; 20650774; 20677014; 20716560; 20720262; 20728566; 20729390; 20729792; 20734064; 20798986; 20852445; 20884100; 20886547; 21045733; 21094112; 21193363; 21300759; 21307141; 21338212; 21378990; 21420394; 21511288; 21572416; 21644229; 21656827; 21676446; 21848792; 21868758; 21896988; 21909110; 21909115; 21919858; 21948762; 21963141; 21966534; 21988832; 22001566; 22048715; 22057025; 22066265; 22071413; 22072737; 22103881; 22174412; 22217842; 22237020; 22238371; 22266943; 22309630; 22331461; 22419734; 22434081; 22456087; 22528335; 22653668; 22714708; 22873692; 22951291; 22954317; 22959498; 23015357; 23036723; 23129512; 23133444; 23229009; 23257735; 23291414; 23350368; 23467202; 23535732; 23551929; 23586722; 23609033; 23620596; 23649771; 23775394; 23809139; 23836902; 23974872; 24001895; 24140098; 24140493
cytochrome P450, family 17, subfamily A, polypeptide 1
Ensembl:ENSG00000148795
HGNC:2593
HPRD:01944
MIM:609300
Vega:OTTHUMG00000018969
Other designations: 17-alpha-hydroxyprogesterone aldolase|CYPXVII|cytochrome P450 17A1|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome P450-C17|cytochrome P450c17|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase
CYP17A1
Bin Zhao, Yue Liu, Oliver He
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
1588
15q21.1
9606
15
GO_0005506 (EC: IEA); GO_0005783 (EC: IDA); GO_0005789 (EC: TAS); GO_0006694 (EC: TAS, PMID:2848247); GO_0006703 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS); GO_0008209 (EC: IEA); GO_0009055 (EC: TAS, PMID:2848247); GO_0016020 (EC: TAS, PMID:2848247); GO_0016125 (EC: TAS); GO_0016712 (EC: TAS, PMID:1371509); GO_0019825 (EC: TAS, PMID:2848247); GO_0020037 (EC: IDA, PMID:19129847); GO_0044281 (EC: TAS); GO_0060736 (EC: IEA); GO_0070330 (EC: IDA, PMID:19129847)
PMID:1371509; 1472013; 1724289; 1825497; 2040633; 2171939; 2541021; 2691883; 2808431; 2848247; 2973313; 3018730; 3390233; 3653507; 3964273; 7690033; 8090165; 8117272; 8265607; 8477708; 8530621; 9177373; 9211678; 9696881; 10566648; 10837748; 11076863; 11140838; 11181459; 11216915; 11232039; 11256614; 11344237; 11469726; 11571725; 11595700; 11756225; 11826265; 11850203; 11850205; 11850206; 11850208; 11850209; 11850210; 11850219; 11850220; 11850221; 11850222; 11850224; 11850225; 11850230; 11850233; 11850235; 11897504; 11903314; 11904449; 11925378; 11927588; 11935306; 11997208; 12036913; 12053085; 12154211; 12160997; 12161013; 12161505; 12164325; 12204674; 12213901; 12351690; 12370109; 12385014; 12428207; 12451990; 12462076; 12462077; 12466340; 12477932; 12489562; 12517592; 12592380; 12602902; 12606587; 12618873; 12620480; 12639945; 12690088; 12705475; 12720534; 12734209; 12736278; 12759877; 12768436; 12788892; 12839940; 12843146; 12846271; 12864794; 12914527; 12917334; 12944421; 14508827; 14517714; 14580722; 14593077; 14602139; 14631363; 14634838; 14714492; 14715870; 14744739; 14747179; 14973387; 14981949; 14990865; 15046111; 15072827; 15072828; 15074077; 15079018; 15083376; 15083377; 15083380; 15083381; 15126575; 15128046; 15132727; 15177662; 15181061; 15183689; 15199113; 15207764; 15229337; 15241822; 15298966; 15319333; 15330195; 15358790; 15364411; 15449726; 15489336; 15582747; 15583024; 15613678; 15640252; 15668497; 15677755; 15688015; 15695318; 15748828; 15774541; 15788666; 15794932; 15800924; 15802318; 15840311; 15862960; 15862961; 15862962; 15955695; 16019206; 16020944; 16024248; 16039845; 16045239; 16086586; 16103457; 16128984; 16146740; 16199862; 16202920; 16213843; 16232327; 16244490; 16251630; 16251760; 16260521; 16269961; 16287071; 16302261; 16303757; 16306085; 16322405; 16344016; 16344560; 16381901; 16392624; 16395678; 16402077; 16406421; 16418790; 16424004; 16426763; 16467490; 16473000; 16498360; 16498361; 16498363; 16498364; 16541304; 16556483; 16566930; 16595205; 16604491; 16608396; 16621515; 16634644; 16641167; 16648498; 16684355; 16691199; 16723309; 16730930; 16733710; 16739881; 16741831; 16767510; 16782804; 16793950; 16798289; 16850246; 16875543; 16882736; 16894362; 16895991; 16896040; 16930994; 16949385; 16949391; 16964243; 16977255; 16997132; 17004113; 17065579; 17066438; 17118999; 17119036; 17158756; 17167982; 17176215; 17187946; 17216495; 17219197; 17325027; 17331471; 17336977; 17359589; 17372263; 17391072; 17400043; 17404019; 17405842; 17415442; 17482958; 17507620; 17507624; 17517397; 17562079; 17574328; 17584767; 17588204; 17589376; 17595315; 17615053; 17646720; 17657731; 17661084; 17662285; 17678915; 17681675; 17682677; 17687621; 17704407; 17766065; 17827443; 17893373; 17953943; 17962916; 17975727; 17979523; 17989043; 17989068; 18030614; 18048499; 18049890; 18083712; 18086758; 18157729; 18159088; 18163429; 18181018; 18182446; 18199708; 18201819; 18245543; 18274619; 18281655; 18299793; 18305346; 18426832; 18437511; 18445666; 18467089; 18483177; 18483761; 18491956; 18497059; 18501301; 18505907; 18510611; 18512790; 18559914; 18568448; 18593984; 18595017; 18601603; 18614276; 18614591; 18617186; 18622258; 18629629; 18636124; 18667686; 18676680; 18767927; 18817841; 18818748; 18820009; 18822378; 18847535; 18930188; 18941892; 18941913; 18955734; 18962445; 18980759; 19015200; 19019335; 19022561; 19064562; 19064572; 19064581; 19083124; 19093296; 19107851; 19116238; 19124504; 19124506; 19129847; 19137777; 19152063; 19158807; 19159688; 19170196; 19172223; 19174490; 19185610; 19194457; 19240151; 19282383; 19299445; 19324338; 19340622; 19366906; 19389254; 19415745; 19419293; 19438456; 19445691; 19453261; 19469636; 19470632; 19478482; 19491387; 19493871; 19500729; 19505920; 19514368; 19527514; 19549443; 19551860; 19555469; 19556341; 19558171; 19570444; 19573564; 19574343; 19589174; 19591804; 19598235; 19604497; 19625176; 19630952; 19639193; 19692168; 19776291; 19782135; 19789370; 19800002; 19800101; 19805543; 19808095; 19815003; 19818337; 19879925; 19883757; 19896534; 19906189; 19906814; 19913121; 19921206; 19933466; 19952760; 19956635; 19969081; 20004389; 20015405; 20026603; 20030115; 20048079; 20052540; 20053928; 20060879; 20064870; 20072949; 20133979; 20140262; 20144226; 20148360; 20164038; 20164294; 20173016; 20184498; 20186154; 20189936; 20193327; 20200332; 20211687; 20214802; 20231365; 20300828; 20305046; 20346360; 20351196; 20381444; 20385561; 20417295; 20430378; 20432167; 20453000; 20505544; 20526739; 20539301; 20546829; 20586553; 20588246; 20588308; 20628086; 20628746; 20634197; 20655525; 20668023; 20688833; 20716560; 20729390; 20734064; 20797716; 20819792; 20881004; 20881960; 20932310; 20937744; 20960227; 21125383; 21154336; 21170323; 21188138; 21198743; 21217768; 21251330; 21269619; 21282199; 21296134; 21300759; 21319151; 21319995; 21320735; 21356374; 21377485; 21392518; 21392519; 21392520; 21414724; 21479914; 21511357; 21622727; 21676395; 21757507; 21771722; 21807013; 21939764; 21948762; 21952832; 21972004; 22057025; 22079757; 22089263; 22104650; 22106445; 22119029; 22130322; 22160249; 22185650; 22217837; 22237979; 22300440; 22315456; 22320986; 22331461; 22335023; 22384274; 22407818; 22426781; 22448795; 22492871; 22508516; 22511967; 22578533; 22633539; 22634420; 22638611; 22675492; 22731640; 22759564; 22773874; 22843875; 22848710; 22887836; 22889864; 22902617; 22915343; 22982181; 23001776; 23029457; 23085504; 23090135; 23110082; 23116507; 23122578; 23129173; 23178495; 23229009; 23239821; 23253631; 23340254; 23342035; 23350368; 23400010; 23438603; 23456168; 23461365; 23518928; 23540392; 23584792; 23599027; 23625281; 23635391; 23643682; 23661022; 23669293; 23700878; 23727336; 23729401; 23747729; 23748068; 23809139; 23846226; 23873111; 24049095
cytochrome P450, family 19, subfamily A, polypeptide 1
Ensembl:ENSG00000137869
HGNC:2594
HPRD:00488
MIM:107910
Vega:OTTHUMG00000131747
Other designations: aromatase|cytochrome P-450AROM|cytochrome P450 19A1|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthase|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
CYP19A1
Bin Zhao, Yue Liu, Oliver He
CA21H
CAH1
CPS1
CYP21
CYP21B
P450c21B
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
1589
DADB-112B14.10-001
6p21.3
9606
6
GO_0004509 (EC: IEA); GO_0005496 (EC: IEA); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006704 (EC: TAS); GO_0006705 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS); GO_0008395 (EC: TAS, PMID:1406709); GO_0016125 (EC: TAS); GO_0020037 (EC: IEA); GO_0044281 (EC: TAS)
PMID:1351548; 1406699; 1406709; 1496017; 1605859; 1644925; 1864962; 1937474; 1985465; 2072928; 2249999; 2303461; 2325662; 2788081; 2827462; 2845408; 3038528; 3137812; 3257825; 3260007; 3260033; 3267225; 3486422; 3487786; 3497399; 3500473; 3871526; 5804199; 7096533; 7629224; 7635470; 7749410; 8081391; 8175971; 8372604; 8478006; 8485582; 8518786; 8675607; 8731325; 8968761; 8989258; 9067760; 9099896; 9187661; 9215318; 9497336; 9580109; 9661649; 10051010; 10072631; 10094562; 10198222; 10207042; 10229037; 10343159; 10364682; 10391209; 10408778; 10408786; 10443693; 10496074; 10720040; 11073721; 11093272; 11232002; 11287026; 11457572; 11581476; 11598371; 11600539; 11692155; 11739456; 11746135; 11836313; 12028996; 12038604; 12050231; 12050257; 12121677; 12213672; 12213891; 12220458; 12222711; 12370110; 12384784; 12464252; 12477932; 12746407; 12788866; 12788880; 12788889; 12855227; 12876419; 12887291; 12915679; 12966197; 14502362; 14514162; 14671153; 14676460; 14676461; 14702039; 14715874; 14733808; 15004406; 15027205; 15028279; 15110320; 15126570; 15128046; 15342556; 15493145; 15572419; 15583024; 15598692; 15608154; 15627780; 15705377; 15751603; 15761541; 15775714; 15793784; 15818055; 15830218; 15858147; 15988383; 16046588; 16238926; 16344560; 16427797; 16487445; 16500637; 16541276; 16648810; 16712666; 16728546; 16788163; 16984992; 17033937; 17047018; 17119906; 17275379; 17466088; 17505149; 17526939; 17551464; 17573904; 17666484; 17803691; 17878254; 18028896; 18039588; 18042312; 18179706; 18204270; 18319307; 18381579; 18392095; 18397975; 18445671; 18478071; 18505908; 18589890; 18636124; 18702679; 18787377; 18825878; 18973462; 19039234; 19058224; 19062540; 19085698; 19116923; 19135723; 19137635; 19158234; 19201236; 19208730; 19226270; 19272182; 19347184; 19420818; 19423540; 19449670; 19453261; 19501079; 19505723; 19531083; 19598235; 19624807; 19773403; 19799922; 19844122; 19856253; 19890026; 19925038; 19930153; 20029944; 20059433; 20070950; 20080860; 20110635; 20132843; 20201644; 20233785; 20301350; 20406964; 20423741; 20438785; 20587039; 20587610; 20617557; 20661889; 20671415; 20818501; 20838032; 20926536; 20970527; 21117955; 21134444; 21164261; 21164262; 21169732; 21175091; 21198393; 21264314; 21274396; 21446712; 21521936; 21534945; 21570420; 21609351; 21646284; 21750395; 21912141; 22001566; 22014889; 22017335; 22020670; 22127631; 22217838; 22308849; 22313422; 22497080; 22561756; 22802425; 22841790; 22873692; 22885098; 22886582; 23027774; 23044877; 23045419; 23073904; 23142378; 23155693; 23211577; 23298233; 23313747; 23322511; 23329749; 23342490; 23359706; 23370425; 23376085; 23386413; 23535732; 23586722; 23692712
cytochrome P450, family 21, subfamily A, polypeptide 2
Ensembl:ENSG00000231852
HGNC:2600
HPRD:01942
MIM:613815
Vega:OTTHUMG00000031069
Other designations: 21-OHase|cytochrome P450 XXI|cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2|cytochrome P450-C21B|steroid 21-hydroxylase|steroid 21-monooxygenase
CYP21A2
Bin Zhao, Yue Liu, Oliver He
CP24
CYP24
HCAI
P450-CC24
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
1591
20q13
9606
20
GO_0001649 (EC: IEP, PMID:17023519); GO_0005506 (EC: IEA); GO_0005743 (EC: TAS); GO_0006766 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS); GO_0008403 (EC: IEA); GO_0016491 (EC: NAS, PMID:7632726); GO_0020037 (EC: TAS, PMID:8506296); GO_0030342 (EC: IDA, PMID:8506296); GO_0033280 (EC: IDA, PMID:16720713); GO_0042359 (EC: TAS); GO_0042369 (EC: NAS, PMID:16720713); GO_0044281 (EC: TAS); GO_0055114 (EC: IDA, PMID:8506296); GO_0070561 (EC: NAS, PMID:16720713)
PMID:7595086; 7632726; 7829101; 7938037; 8266831; 8440135; 8506296; 10218951; 11149490; 11780052; 12477932; 12485911; 12641633; 12855575; 14665637; 14760115; 15078099; 15128046; 15146197; 15358094; 15583024; 15630458; 15788398; 15919092; 15951480; 16457885; 16516540; 16600026; 16617161; 16691293; 16708384; 16720713; 17023519; 17079137; 17223345; 17244366; 17254772; 17368180; 17426122; 17475215; 17585873; 17606874; 17646648; 17875655; 17932346; 18467787; 18676680; 18824104; 18843020; 19097033; 19170196; 19237542; 19255064; 19343046; 19393625; 19453261; 19454612; 19505920; 19625176; 19667160; 19692168; 19706847; 19852851; 19891555; 19901270; 19913121; 19922790; 20007432; 20304053; 20304056; 20304059; 20394945; 20398751; 20450955; 20453000; 20460683; 20467438; 20541252; 20587525; 20591973; 20628086; 20654748; 20687218; 20809279; 20831823; 20847308; 20877624; 21169243; 21385079; 21440908; 21441443; 21675912; 21697097; 21725204; 21828234; 21833088; 21906983; 22213328; 22285938; 22511602; 22612324; 22648713; 22649517; 22690899; 22841393; 22871965; 22940288; 22984610; 23042114; 23059474; 23155244; 23169318; 23293122; 23377224; 23393347; 23423976; 23435876; 23456391; 23463632; 23485543; 23674869; 23826131; 24068962
cytochrome P450, family 24, subfamily A, polypeptide 1
Ensembl:ENSG00000019186
HGNC:2602
HPRD:00522
MIM:126065
Vega:OTTHUMG00000032773
Other designations: 1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase
CYP24A1
Bin Zhao, Yue Liu, Oliver He
CP26
CYP26
P450RAI
P450RAI1
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
1592
RP11-348J12.1
10q23-q24
9606
10
GO_0001972 (EC: IDA, PMID:10823918); GO_0005506 (EC: IEA); GO_0005789 (EC: TAS); GO_0006766 (EC: TAS); GO_0006805 (EC: TAS); GO_0007417 (EC: IEA); GO_0008152 (EC: TAS, PMID:9228017); GO_0008401 (EC: IDA, PMID:10823918); GO_0009952 (EC: IEA); GO_0014032 (EC: IEA); GO_0019825 (EC: TAS, PMID:9228017); GO_0020037 (EC: NAS, PMID:9228017); GO_0034653 (EC: IDA, PMID:10823918); GO_0044281 (EC: TAS); GO_0048384 (EC: IEA); GO_0048387 (EC: TAS, PMID:14532297); GO_0071300 (EC: IEA)
PMID:8601734; 9228017; 9228041; 9521883; 9716180; 9826557; 10583049; 10823918; 10874126; 10976925; 12727970; 14532297; 14702039; 15128046; 15281009; 16053444; 16194896; 16463413; 16778795; 16933217; 17059167; 17218384; 17460545; 18059332; 18992717; 19519282; 19553612; 19703508; 20167577; 20375987; 20513361; 20682464; 20686565; 20693622; 21521770; 21850183; 21975512; 22020119; 22179182; 23396134; 24043786
cytochrome P450, family 26, subfamily A, polypeptide 1
Ensembl:ENSG00000095596
HGNC:2603
HPRD:03759
MIM:602239
Vega:OTTHUMG00000018765
Other designations: P450, retinoic acid-inactivating, 1|cytochrome P450 26A1|cytochrome P450 retinoic acid-inactivating 1|cytochrome P450, subfamily XXVIA, polypeptide 1|cytochrome P450RAI|hP450RAI|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome
CYP26A1
Bin Zhao, Yue Liu, Oliver He
CP27
CTX
CYP27
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
1593
2q35
9606
2
GO_0005506 (EC: IEA); GO_0005743 (EC: IEA); GO_0005759 (EC: TAS); GO_0006699 (EC: TAS); GO_0006805 (EC: TAS); GO_0008203 (EC: IEA); GO_0008206 (EC: TAS); GO_0008395 (EC: TAS, PMID:9790667); GO_0016125 (EC: TAS); GO_0020037 (EC: IEA); GO_0030343 (EC: IEA); GO_0031073 (EC: IEA); GO_0044281 (EC: TAS); GO_0047749 (EC: IEA)
PMID:1708392; 2019602; 7690968; 7915755; 8125298; 8514861; 9186905; 9215552; 9790667; 10519880; 11167933; 11604260; 11903362; 12000359; 12011083; 12117727; 12119285; 12242561; 12477932; 12777473; 14672608; 14741198; 15128046; 15340076; 15489334; 15533057; 15708352; 16157755; 16372260; 16584175; 16930540; 17088262; 17292862; 17482558; 17697869; 17875655; 18227423; 18791760; 19255064; 19343046; 19671838; 19852851; 19913121; 20149624; 20301583; 20402754; 20450308; 20558929; 20628086; 20654748; 20809279; 20855565; 20877624; 21049985; 21134350; 21258856; 21411718; 21498512; 21958693; 21988832; 22018287; 22185844; 22227097; 22509407; 24096962
cytochrome P450, family 27, subfamily A, polypeptide 1
Ensembl:ENSG00000135929
HGNC:2605
HPRD:05939
MIM:606530
Vega:OTTHUMG00000048238
Other designations: 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase|5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase|cholestanetriol 26-monooxygenase|cytochrome P-450C27/25|cytochrome P450 27|cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1|sterol 26-hydroxylase, mitochondrial|sterol 27-hydroxylase|vitamin D(3) 25-hydroxylase
CYP27A1
Bin Zhao, Yue Liu, Oliver He
CP2B
CYP1
CYP1alpha
CYP27B
P450c1
PDDR
VDD1
VDDR
VDDRI
VDR
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
1594
12q14.1
9606
12
GO_0004498 (EC: IDA, PMID:15795327); GO_0005506 (EC: IEA); GO_0005737 (EC: IDA, PMID:15589699); GO_0005739 (EC: ISS); GO_0005739 (EC: TAS, PMID:9333115); GO_0005741 (EC: TAS); GO_0006766 (EC: TAS); GO_0006805 (EC: TAS); GO_0006816 (EC: ISS); GO_0008202 (EC: TAS); GO_0008285 (EC: IDA, PMID:16549446); GO_0010956 (EC: IDA, PMID:16549446); GO_0010980 (EC: IDA, PMID:16549446); GO_0020037 (EC: IEA); GO_0030282 (EC: IEP, PMID:17023519); GO_0030308 (EC: IMP, PMID:12496369); GO_0030500 (EC: IMP, PMID:9415400); GO_0032496 (EC: IDA, PMID:12855575); GO_0033280 (EC: IDA, PMID:16549446); GO_0034341 (EC: IDA, PMID:9282826); GO_0036378 (EC: IDA, PMID:15795327); GO_0042359 (EC: IDA, PMID:9415400); GO_0042359 (EC: TAS); GO_0042369 (EC: IEA); GO_0043627 (EC: IEP, PMID:15795327); GO_0044281 (EC: TAS); GO_0045618 (EC: IMP, PMID:12496369); GO_0046697 (EC: IEP, PMID:16720713); GO_0055074 (EC: IMP, PMID:9415400); GO_0070314 (EC: IMP, PMID:12496369); GO_0070564 (EC: IDA, PMID:16549446)
PMID:1662663; 1690216; 1971995; 9282826; 9295274; 9333115; 9344864; 9415400; 9428799; 9486994; 9837822; 10320521; 10359826; 10566658; 11799066; 12039697; 12050193; 12050281; 12107095; 12137802; 12161526; 12386916; 12457456; 12477932; 12496369; 12520522; 12746631; 12855575; 14671156; 15225751; 15243130; 15296474; 15331405; 15342556; 15583024; 15589699; 15795327; 15934135; 15947108; 15951480; 15956353; 16061850; 16549446; 16720713; 17023519; 17079137; 17207990; 17207994; 17223345; 17236759; 17250953; 17254772; 17267208; 17287116; 17368179; 17395559; 17395703; 17426122; 17488797; 17606874; 17878529; 17932346; 18476984; 18495603; 18676680; 18689381; 18767073; 18767934; 18768522; 18843020; 19064572; 19154546; 19170196; 19219539; 19255064; 19343046; 19453261; 19454612; 19505920; 19524013; 19525955; 19625176; 19667158; 19706847; 19783860; 19852851; 19891555; 19913121; 19951419; 19966181; 19998245; 20007432; 20082271; 20152900; 20304056; 20453000; 20518841; 20534770; 20619365; 20628086; 20648053; 20654748; 20687218; 20701904; 20809279; 20831823; 20847308; 20877624; 21107545; 21145801; 21440908; 21441443; 21542014; 21833088; 21869486; 22190362; 22326730; 22443290; 22446158; 22511602; 22516854; 22547098; 22588163; 22612324; 22963605; 22995334; 23045480; 23063903; 23149444; 23286944; 23334593; 23423976; 23444327; 23483640; 23614044; 23894780; 24308945
cytochrome P450, family 27, subfamily B, polypeptide 1
Ensembl:ENSG00000111012
HGNC:2606
HPRD:02031
MIM:609506
Vega:OTTHUMG00000170457
Other designations: 1alpha(OH)ase|25 hydroxyvitamin D3-1-alpha hydroxylase|25-OHD-1 alpha-hydroxylase|25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial|VD3 1A hydroxylase|calcidiol 1-monooxygenase|cytochrome P450 subfamily XXVIIB polypeptide 1|cytochrome P450C1 alpha|cytochrome P450VD1-alpha|cytochrome p450 27B1
CYP27B1
Bin Zhao, Yue Liu, Oliver He
CP51
CYP51
CYPL1
LDM
P450-14DM
P450L1
WEB: http://www.ncbi.nlm.nih.gov/gene
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
1595
7q21.2
9606
7
GO_0005506 (EC: IEA); GO_0005783 (EC: IDA); GO_0005789 (EC: TAS); GO_0006694 (EC: IDA); GO_0006695 (EC: TAS); GO_0006805 (EC: TAS); GO_0008398 (EC: IDA); GO_0016021 (EC: IEA); GO_0016125 (EC: TAS); GO_0020037 (EC: IDA); GO_0033488 (EC: IEA); GO_0044281 (EC: TAS); GO_0070988 (EC: IDA)
PMID:8024575; 8619637; 8797093; 8809088; 8845856; 8975714; 11678326; 12145339; 12477932; 12690205; 12824470; 12853948; 14702039; 15128046; 15489334; 15611056; 16344560; 18660489; 18676367; 19322201; 20149798; 20547249; 21139048; 21890473; 21906983; 21963094; 21987572; 21988832; 22053931; 22180046; 23000965; 24362992; 24502137
cytochrome P450, family 51, subfamily A, polypeptide 1
Ensembl:ENSG00000001630
HGNC:2649
HPRD:03381
MIM:601637
Vega:OTTHUMG00000131131
Other designations: CYPLI|cytochrome P450 51A1|cytochrome P450, 51 (lanosterol 14-alpha-demethylase)|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase
CYP51A1
Bin Zhao, Yue Liu, Oliver He
DOC-2
DOC2
WEB: http://www.ncbi.nlm.nih.gov/gene
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
1601
5p13.1
20140408
9606
5
protein-coding
Official from a nomenclature committee
GO_0000904 (EC: IEA); GO_0001701 (EC: IEA); GO_0001921 (EC: IEA); GO_0001934 (EC: IMP, PMID: 12805222); GO_0005178 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11387212); GO_0005546 (EC: IEA); GO_0005730 (EC: IDA); GO_0005765 (EC: TAS); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005905 (EC: IDA, PMID: 12857860); GO_0006907 (EC: IEA); GO_0006915 (EC: IEA); GO_0007257 (EC: IEA); GO_0007492 (EC: IEA); GO_0007588 (EC: IEA); GO_0008022 (EC: IPI, PMID: 15837803); GO_0008283 (EC: TAS, PMID: 9620555); GO_0010718 (EC: IDA, PMID: 15734730); GO_0010862 (EC: IDA, PMID: 11387212); GO_0015031 (EC: IEA); GO_0016055 (EC: IEA); GO_0016324 (EC: IEA); GO_0030099 (EC: IEA); GO_0030132 (EC: IEA); GO_0030335 (EC: IEA); GO_0030511 (EC: IDA, PMID: 11387212); GO_0030665 (EC: IEA); GO_0032091 (EC: IMP, PMID: 12805222); GO_0032436 (EC: IMP, PMID: 12805222); GO_0032968 (EC: IEA); GO_0035612 (EC: IEA); GO_0035615 (EC: IMP, PMID: 16984970); GO_0038024 (EC: IMP, PMID: 16984970); GO_0043066 (EC: IDA, PMID: 15734730); GO_0043231 (EC: IDA); GO_0045807 (EC: IMP); GO_0045892 (EC: IMP, PMID: 12805222); GO_0045893 (EC: IMP, PMID: 12805222); GO_0046332 (EC: IDA, PMID: 11387212); GO_0048268 (EC: IEA); GO_0060391 (EC: IDA, PMID: 11387212); GO_0060766 (EC: IMP, PMID: 16267015); GO_0061024 (EC: TAS); GO_0070022 (EC: IDA, Qualifier: colocalizes_with, PMID: 11387212); GO_0071560 (EC: IEA); GO_0090090 (EC: IMP, PMID: 12805222); GO_1900026 (EC: IEA); GO_2000096 (EC: IMP, PMID: 12805222); GO_2000370 (EC: IMP, PMID: 16984970); GO_2000643 (EC: IMP); GO_2001046 (EC: IEA); GO_2001237 (EC: IEA)
PMID: 8314147; 8660969; 8889548; 9569023; 9620555; 10340382; 10542228; 10769163; 11039902; 11161789; 11247302; 11371563; 11387212; 11812785; 11906161; 11927540; 11967127; 12473651; 12477932; 12606711; 12805222; 12853125; 12857860; 12881709; 14596919; 14669280; 15134832; 15231748; 15247260; 15280374; 15302935; 15489334; 15734730; 15837803; 15894542; 16061224; 16267015; 16713569; 16870701; 16964243; 16984970; 17009406; 17081983; 17110338; 17115114; 17187061; 17474147; 17671122; 18070591; 18354201; 18429820; 18582465; 19204726; 19423540; 19531213; 19581412; 19738201; 19767570; 19855435; 19956625; 20379614; 20383146; 20406964; 20438785; 20448150; 20525238; 20592473; 20628624; 20936779; 21063401; 21097498; 21139048; 21496867; 21573318; 21725366; 21963094; 21987572; 21988832; 21995445; 22158540; 22218591; 22265793; 22323290; 22399289; 22558309; 22648170; 22705885; 22898784; 22977233; 23005040; 23263486; 23817569; 23909735; 24186266
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Ensembl:ENSG00000153071
HGNC:2662
HPRD:03139
MIM:601236
Vega:OTTHUMG00000162043
Other designations: differentially-expressed protein 2|disabled homolog 2|disabled homolog 2, mitogen-responsive phosphoprotein
DAB2
Bin Zhao, Yue Liu, Oliver He
DDIT1
GADD45
WEB: http://www.ncbi.nlm.nih.gov/gene
GADD45A
growth arrest and DNA-damage-inducible, alpha
1647
RP5-975D15.1
1p31.2
9606
1
Official from a nomenclature committee
GO_0000079 (EC: TAS, PMID: 10747892); GO_0000185 (EC: IDA, PMID: 9827804); GO_0001047 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12716909); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA, PMID: 9827804); GO_0006281 (EC: TAS, PMID: 7973727); GO_0006469 (EC: IEA); GO_0006915 (EC: TAS, PMID: 10828065); GO_0007050 (EC: IEA); GO_0007098 (EC: IEA); GO_0042770 (EC: IMP); GO_0043065 (EC: IDA, PMID: 9827804); GO_0046330 (EC: IDA, PMID: 9827804); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071479 (EC: IMP); GO_1900745 (EC: IDA, PMID: 9827804); GO_2000379 (EC: IMP)
PMID: 1990262; 7478510; 7478594; 7784094; 7798274; 7973727; 8226988; 9178907; 9705499; 9827804; 10022855; 10362260; 10747892; 10828065; 10872826; 10912791; 10973963; 11076863; 11256614; 11498536; 11777930; 11893252; 12124778; 12168790; 12171872; 12477932; 12483522; 12716909; 12748288; 14506229; 14517299; 14586402; 14635187; 14647444; 15203190; 15328371; 15353598; 15489334; 15489336; 15616591; 15623356; 15642443; 15644315; 15650754; 15735726; 15736438; 15899854; 16157202; 16169070; 16189514; 16353139; 16381901; 16421274; 16772293; 16827157; 16951143; 16997058; 17140287; 17178890; 17230496; 17436581; 17474084; 17599061; 17616671; 17703175; 18243530; 18296737; 18350249; 18369439; 18413758; 18472964; 18480060; 18611122; 18760377; 18950845; 19048389; 19052873; 19064572; 19128509; 19190346; 19298651; 19452502; 19459735; 19536092; 19550118; 19593445; 19596022; 19728081; 19789190; 20012529; 20131288; 20444249; 20460379; 20639865; 20652500; 20932473; 21048031; 21120602; 21139048; 21211282; 21368893; 21739277; 21813510; 21890473; 21900206; 21906983; 21931671; 21963094; 21986581; 21988832; 22135303; 22313682; 22430142; 22521726; 22718299; 22825327; 22970179; 23000965; 23071284; 23114628; 23158659; 23187294; 23227140; 23478041; 23485469; 23563151; 23603344; 23616123; 23706118; 24104470; 24104471; 24104476
growth arrest and DNA-damage-inducible, alpha
Ensembl:ENSG00000116717
HGNC:4095
HPRD:00528
MIM:126335
Vega:OTTHUMG00000009374
Other designations: DDIT-1|DNA damage-inducible transcript 1 protein|DNA damage-inducible transcript-1|DNA-damage-inducible transcript 1|growth arrest and DNA damage-inducible protein GADD45 alpha|growth arrest and DNA-damage-inducible 45 alpha
GADD45A
Other designations: C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA damage-inducible protein GADD153
DDIT3
DNA-damage-inducible transcript 3
Ensembl:ENSG00000175197
HGNC:2726
HPRD:00529
MIM:126337
NCBI-Human-GeneID:1649
CEBPZ
CHOP
CHOP-10
CHOP10
GAD153
DDIT3
NCBI-Human-GeneID:1649
http://www.ncbi.nlm.nih.gov/gene/1649
Bin Zhao, Yue Liu, Oliver He
HLR2
P54
RCK
WEB: http://www.ncbi.nlm.nih.gov/gene
DDX6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
1656
11q23.3
9606
11
Official from a nomenclature committee
GO_0000288 (EC: TAS); GO_0000932 (EC: IDA, PMID: 16699599); GO_0003724 (EC: TAS, PMID: 1579499); GO_0004386 (EC: TAS, PMID: 1394235); GO_0005515 (EC: IPI, PMID: 16364915); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0008026 (EC: IEA); GO_0010467 (EC: TAS); GO_0010494 (EC: IDA, PMID: 17392519); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0016442 (EC: IDA); GO_0033962 (EC: IDA); GO_0043231 (EC: IDA); GO_0043928 (EC: TAS); GO_0044822 (EC: IDA)
PMID: 1394235; 1579499; 7614484; 8816452; 10319407; 10360675; 10737800; 11839790; 12477932; 12823589; 14684915; 14702039; 15489334; 16147992; 16344560; 16364915; 16611246; 16699599; 16756390; 17207965; 17353931; 17392519; 17898068; 18378046; 18769115; 19285948; 19297524; 19380743; 19542561; 19560422; 19738201; 20020773; 20158304; 20360068; 20392846; 20884783; 21030982; 21110914; 21139048; 21145461; 21383967; 21906983; 21957497; 22022269; 22190034; 22203041; 22268729; 22505724; 22797925; 22836354; 22851315; 22939629; 22951725; 22965301; 23293030; 23455922; 23535175; 23602568; 23826300; 23932921; 24130170; 24255178; 24457600
DEAD (Asp-Glu-Ala-Asp) box helicase 6
HGNC:2747
HPRD:02638
MIM:600326
Other designations: ATP-dependent RNA helicase p54|DEAD (Asp-Glu-Ala-Asp) box polypeptide 6|DEAD box protein 6|DEAD box-6|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)|oncogene RCK|probable ATP-dependent RNA helicase DDX6
DDX6
Bin Zhao, Yue Liu, Oliver He
DHFRP1
DYR
WEB: http://www.ncbi.nlm.nih.gov/gene
DHFR
dihydrofolate reductase
1719
5q11.2-q13.2
20140408
9606
5
protein-coding
Official from a nomenclature committee
PMID: 1731871; 1935897; 2248959; 2592384; 2859520; 3185016; 3383852; 6235374; 6306253; 6323448; 6504041; 6687716; 6750132; 8527095; 8559246; 8976559; 9119086; 9374868; 10749676; 10898545; 11448909; 11779239; 11964483; 11996001; 12084458; 12096917; 12384595; 12477932; 12588981; 12612070; 12788094; 12812497; 14664697; 14679136; 14735580; 15039552; 15489334; 15755837; 15817466; 16116078; 16124424; 16196087; 16467096; 16735474; 16969375; 17237763; 17336564; 17413111; 17449906; 17486595; 17597297; 17683969; 17917571; 18045573; 18056255; 18093916; 18247058; 18451149; 18498051; 18636124; 18676680; 18682947; 18785313; 18799873; 18818748; 18988749; 19019335; 19022952; 19048631; 19055622; 19064572; 19064578; 19161160; 19170196; 19196009; 19336370; 19353223; 19360472; 19461557; 19471022; 19493349; 19527514; 19533788; 19536847; 19578876; 19625176; 19666584; 19683694; 19692168; 19706381; 19727391; 19776634; 19861437; 19898482; 19913121; 20031554; 20237949; 20347265; 20472929; 20544798; 20615890; 20628086; 20634891; 20639865; 20670920; 20737570; 20834190; 20948192; 21120433; 21310276; 21310277; 21857842; 21890473; 21906983; 21963094; 22005284; 22024482; 22324981; 22505724; 22797925; 22954684; 22994778; 23000965; 23053953; 23197646; 23421317; 23707606; 23726796; 23733948; 23838799; 24053334; 24077226
dihydrofolate reductase
Ensembl:ENSG00000228716
HGNC:2861
HPRD:00519
MIM:126060
Vega:OTTHUMG00000162529
DHFR
Bin Zhao, Yue Liu, Oliver He
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
WEB: http://www.ncbi.nlm.nih.gov/gene
NQO1
NAD(P)H dehydrogenase, quinone 1
1728
16q22.1
9606
16
Official from a nomenclature committee
GO_0003955 (EC: IEA); GO_0004128 (EC: TAS, PMID: 9579781); GO_0004784 (EC: IEA); GO_0005515 (EC: IPI, PMID: 18388957); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006521 (EC: TAS); GO_0006801 (EC: IEA); GO_0006805 (EC: TAS, PMID: 10393963); GO_0006809 (EC: TAS, PMID: 9579781); GO_0006979 (EC: IEA); GO_0007271 (EC: TAS, PMID: 9579781); GO_0007568 (EC: IEA); GO_0007584 (EC: IEA); GO_0009636 (EC: TAS, PMID: 10393963); GO_0032355 (EC: IEA); GO_0034641 (EC: TAS); GO_0043025 (EC: IEA); GO_0043086 (EC: IEA); GO_0043525 (EC: IEA); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0045471 (EC: IEA)
PMID: 1340765; 1657151; 1737339; 2071140; 2843525; 8125298; 9230185; 9579781; 10393963; 10447260; 10487530; 10543876; 10706635; 11051261; 11219774; 11319169; 11520401; 11551408; 11679176; 11688992; 11701227; 11722480; 11766168; 11773862; 11774269; 11810042; 11821413; 11840286; 11888914; 11894133; 11895912; 11943609; 11948402; 11956078; 11967624; 12018106; 12036913; 12037698; 12163326; 12164325; 12171070; 12171760; 12172217; 12232053; 12370194; 12383707; 12393447; 12393620; 12397416; 12417987; 12419832; 12439220; 12460800; 12468438; 12477932; 12480594; 12529318; 12694753; 12711112; 12713578; 12718576; 12718704; 12771035; 12777965; 12834817; 12854127; 12867492; 12960511; 13130177; 14506737; 14568289; 14592434; 14634213; 14634838; 14669229; 14675732; 14688016; 14694720; 14716779; 14720419; 14729580; 14985350; 15028279; 15061915; 15079792; 15111988; 15116053; 15138483; 15151706; 15184245; 15196853; 15219943; 15226677; 15279067; 15280903; 15298951; 15312971; 15334552; 15352038; 15355699; 15365958; 15370874; 15382274; 15385560; 15466980; 15489334; 15498787; 15590400; 15618957; 15640066; 15661231; 15694256; 15714076; 15727169; 15731166; 15734732; 15746160; 15747169; 15748501; 15749015; 15763338; 15767364; 15781212; 15808404; 15829318; 15838728; 15938845; 16003741; 16006997; 16038261; 16039674; 16054862; 16079101; 16157195; 16170238; 16172237; 16235982; 16235998; 16266898; 16284498; 16297214; 16321221; 16341674; 16343742; 16369108; 16385446; 16413497; 16520888; 16532285; 16595077; 16598069; 16610002; 16620556; 16702380; 16775388; 16818284; 16978807; 16985026; 17011189; 17027152; 17082176; 17113562; 17118447; 17119198; 17164365; 17166422; 17178637; 17179690; 17188257; 17332305; 17332311; 17337051; 17363580; 17367411; 17372252; 17378176; 17395013; 17400324; 17405841; 17424838; 17428572; 17449559; 17469025; 17476281; 17496311; 17507624; 17541156; 17575500; 17581325; 17603928; 17619904; 17644186; 17652311; 17669387; 17726138; 17869325; 17885617; 17901563; 18024413; 18029348; 18034618; 18061666; 18061941; 18074351; 18091324; 18098117; 18156703; 18203021; 18214807; 18218609; 18225579; 18253865; 18388957; 18393254; 18404535; 18407955; 18413200; 18416817; 18444152; 18444911; 18457324; 18510611; 18511948; 18569591; 18587252; 18601742; 18632753; 18636124; 18676018; 18676680; 18720901; 18784359; 18798003; 18813798; 18820947; 18836923; 18936436; 18945694; 18950733; 18977034; 18981090; 18986377; 18992148; 19012493; 19012698; 19017358; 19027876; 19027952; 19059883; 19074885; 19096102; 19138946; 19151739; 19162321; 19170196; 19174490; 19179423; 19214744; 19229058; 19251446; 19330589; 19336370; 19339270; 19360290; 19362588; 19382518; 19415745; 19456854; 19494791; 19549356; 19591959; 19593802; 19596483; 19625176; 19628038; 19651439; 19652895; 19657853; 19661089; 19671875; 19688691; 19692168; 19705749; 19715479; 19736056; 19738201; 19759547; 19778569; 19789190; 19808663; 19822020; 19899130; 19913121; 19952119; 20026093; 20027111; 20028737; 20049130; 20049212; 20056632; 20085630; 20091863; 20100551; 20110814; 20193673; 20194081; 20198579; 20200430; 20204281; 20214802; 20226854; 20331656; 20371868; 20373852; 20375710; 20391128; 20437850; 20453000; 20461808; 20480521; 20480816; 20511665; 20526719; 20526805; 20534171; 20568895; 20593958; 20599494; 20613985; 20628086; 20634891; 20663217; 20701904; 20819778; 20824655; 20851451; 20878130; 20935060; 20951227; 20962519; 20966810; 21041608; 21073132; 21117316; 21133623; 21139048; 21176850; 21211285; 21220432; 21253823; 21294640; 21329464; 21351093; 21479364; 21480392; 21502369; 21518531; 21524888; 21531452; 21577322; 21602889; 21605663; 21706157; 21718050; 21755707; 21756955; 21800014; 21861350; 21906983; 21946896; 21963094; 21964527; 21989715; 22016051; 22017531; 22021338; 22116627; 22215148; 22249251; 22272361; 22306249; 22387672; 22393995; 22483869; 22586705; 22623428; 22736108; 22770696; 22793692; 22853296; 22911602; 22925602; 22939629; 22960073; 22972504; 22976839; 22984577; 23000965; 23054000; 23065291; 23066387; 23066397; 23086932; 23110137; 23215885; 23249637; 23275341; 23276910; 23360829; 23390006; 23458878; 23468244; 23497461; 23643325; 23648480; 23651475; 23725139; 23749485; 23803694; 23824909; 23840148; 23852860; 23860519; 23873104; 23893397; 23918565; 24053646; 24140708
NAD(P)H dehydrogenase, quinone 1
Ensembl:ENSG00000181019
HGNC:2874
HPRD:00518
MIM:125860
Vega:OTTHUMG00000137575
Other designations: DT-diaphorase|NAD(P)H dehydrogenase [quinone] 1|NAD(P)H:Quinone acceptor oxidoreductase type 1|NAD(P)H:menadione oxidoreductase 1|NAD(P)H:quinone oxidoreductase 1|NAD(P)H:quinone oxireductase|azoreductase|diaphorase (NADH/NADPH) (cytochrome b-5 reductase)|diaphorase-4|dioxin-inducible 1|menadione reductase|phylloquinone reductase|quinone reductase 1
NQO1
Bin Zhao, Yue Liu, Oliver He
DHP
DHPDHASE
DPD
WEB: http://www.ncbi.nlm.nih.gov/gene
DPYD
dihydropyrimidine dehydrogenase
1806
1p22
9606
1
Official from a nomenclature committee
GO_0004158 (EC: IEA); GO_0005737 (EC: IDA, PMID: 1512248); GO_0005829 (EC: IDA, PMID: 9348115); GO_0005829 (EC: TAS); GO_0006145 (EC: IMP, PMID: 11988088); GO_0006206 (EC: TAS); GO_0006208 (EC: IMP, PMID: 11988088); GO_0006208 (EC: ISS); GO_0006210 (EC: IDA, PMID: 10410956); GO_0006212 (EC: IDA, PMID: 1512248); GO_0006214 (EC: IDA, PMID: 1512248); GO_0006222 (EC: IEA); GO_0017113 (EC: IDA, PMID: 10410956); GO_0017113 (EC: IMP, PMID: 11988088); GO_0017113 (EC: ISS); GO_0017113 (EC: TAS); GO_0019483 (EC: IEA); GO_0042803 (EC: IDA, PMID: 1512248); GO_0042803 (EC: ISS); GO_0044281 (EC: TAS); GO_0046135 (EC: TAS); GO_0046872 (EC: IEA); GO_0050660 (EC: ISS); GO_0050661 (EC: ISS); GO_0051539 (EC: IEA); GO_0055086 (EC: TAS)
PMID: 1512248; 1544906; 1901022; 2319593; 2528450; 3335642; 7713523; 8083224; 8221682; 8892022; 9135003; 9170156; 9266349; 9348115; 9439663; 9464498; 10410956; 10606257; 10923099; 11072080; 11267945; 11555601; 11862480; 11895907; 11988088; 11992400; 12025228; 12047484; 12209976; 12360106; 12477932; 12576451; 12822071; 12844478; 12851836; 14519634; 14562021; 14654904; 14702180; 15017333; 15025795; 15069545; 15102667; 15132136; 15254700; 15316940; 15709212; 15939134; 15993511; 15999119; 16021908; 16132996; 16328315; 16344560; 16361556; 16771603; 16786143; 16806531; 16820886; 16969493; 17000685; 17046731; 17121937; 17165084; 17203168; 17335544; 17375478; 17377791; 17397246; 17417073; 17445431; 17582309; 17582310; 17612628; 17699798; 17828463; 17848752; 17876700; 17905396; 18004243; 18075467; 18225548; 18299612; 18347391; 18443386; 18452418; 18537153; 18619742; 18705276; 18937829; 19020767; 19104657; 19154585; 19178088; 19288105; 19295264; 19296131; 19343046; 19473056; 19530960; 19546880; 19571608; 19636001; 19724871; 19795123; 19822137; 19858398; 19898482; 19956635; 20037211; 20157331; 20379614; 20385995; 20407238; 20453000; 20507294; 20530282; 20544545; 20570913; 20647221; 20647710; 20653680; 20665215; 20714149; 20714877; 20803296; 20809970; 20819423; 20837458; 21057378; 21111509; 21114665; 21498394; 21507922; 21612699; 21822266; 21919605; 21963094; 21965773; 21987572; 22003227; 22006578; 22143355; 22199347; 22270332; 22306127; 22339448; 22490566; 22505724; 22510597; 22593457; 22641663; 22688191; 22939629; 23313143; 23401991; 23453885; 23588312; 23603345; 23736036; 23781135; 23930673; 23960437; 23974872; 24104963
dihydropyrimidine dehydrogenase
Ensembl:ENSG00000188641
HGNC:3012
HPRD:02036
MIM:612779
Vega:OTTHUMG00000039683
Other designations: dihydropyrimidine dehydrogenase [NADP(+)]|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase
DPYD
Bin Zhao, Yue Liu, Oliver He
DIP
DSIPI
GILZ
TSC-22R
hDIP
WEB: http://www.ncbi.nlm.nih.gov/gene
TSC22D3
TSC22 domain family, member 3
1831
RP13-364K23.1
Xq22.3