TOXic Process Ontology (TXPO)
type: Ontology
version IRI: txpo.owl
creator: Yuki Yamagata yuki.yamagata at riken.jp
description: Elucidating the mechanism of toxicity is crucial in drug safety evaluations. TOXic Process Ontology (TXPO) systematizes a wide variety of terms involving toxicity courses and processes. The first version of TXPO focuses on liver toxicity. The TXPO contains an is-a hierarchy that is organized into three layers: the top layer contains general terms, mostly derived from the Basic Formal Ontology. The intermediate layer contains biomedical terms in OBO foundry from UBERON, Cell Ontology, NCBI Taxon, ChEBI, Gene Ontology, PATO, OGG, INOH, HINO, NCIT, DOID and Relational ontology (RO). The lower layer contains toxicological terms. In applied work, we have developed a prototype of TOXPILOT, a TOXic Process InterpretabLe knOwledge sysTem. TOXPILOT provides visualization maps of the toxic course, which facilitates capturing the comprehensive picture for understanding toxicity mechanisms. A prototype of TOXPILOT is available: https://toxpilot.nibiohn.go.jp
license: http://creativecommons.org/licenses/by/4.0/
comment: An extension version ontology, which focuses on the homeostasis imbalance process affected by drugs, viruses, and other factors, is available: Homeostasis imbalance process (HoIP) ontology https://bioportal.bioontology.org/ontologies/HOIP
version info: 2022/12/07

editor preferred term
type: AnnotationProperty

example of usage
type: AnnotationProperty

has curation status
type: AnnotationProperty

definition
type: AnnotationProperty

editor note
type: AnnotationProperty

term editor
type: AnnotationProperty

alternative term
type: AnnotationProperty

definition source
type: AnnotationProperty

curator note
type: AnnotationProperty

imported from
type: AnnotationProperty
editor preferred term: imported from
has curation status: IAO_0000125
definition: For external terms/classes, the ontology from which the term was imported
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

elucidation
type: AnnotationProperty

has associated axiom(nl)
type: AnnotationProperty

has associated axiom(fol)
type: AnnotationProperty

has axiom label
type: AnnotationProperty

symbol from nomenclature authority
type: AnnotationProperty
definition: the symbol assigned by the nomenclature authority

full name from nomenclature authority
type: AnnotationProperty

NCBI GeneID
type: AnnotationProperty
definition: A GeneID in the NCBI Gene database

NCBI LocusTag
type: AnnotationProperty
definition: the NCBI LocusTag name of a gene

gene map location
type: AnnotationProperty

organism NCBITaxon ID
type: AnnotationProperty
definition: The NCBITaxon ontology ID of an organism.

chromosome ID of gene
type: AnnotationProperty

nomenclature status
type: AnnotationProperty

has GO association
type: AnnotationProperty

has PubMed association
type: AnnotationProperty

is opposite_of
type: AnnotationProperty
definition: X is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).

external definition
type: AnnotationProperty

homology notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

taxon notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.

function_notes
type: AnnotationProperty
definition: Notes on the evolved function of instances of this class.

structure_notes
type: AnnotationProperty
definition: Notes on the structure, composition or histology of instances of this class.

development_notes
type: AnnotationProperty
definition: Notes on the ontogenic development of instances of this class.

fma_set_term
type: AnnotationProperty

formula
type: AnnotationProperty

smiles
type: AnnotationProperty

Language
type: AnnotationProperty
description: Recommended best practice is to use RFC 3066 [RFC3066], which, in conjunction with ISO 639 [ISO639], defines two- and three-letter primary language tags with optional subtags. Examples include "en" or "eng" for English, "akk" for Akkadian, and "en-GB" for English used in the United Kingdom.
comment: A language of the intellectual content of the resource.

auto-generated-by
type: AnnotationProperty

date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
editor preferred term: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
database_cross_reference: http://www.obofoundry.org/ro/#OBO_REL:part_of
has_exact_synonym: part_of

has part
type: ObjectProperty
sub property of: topObjectProperty
type: TransitiveProperty
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
definition: a core relation that holds between a whole and its part
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.

occurs in
type: ObjectProperty
inverse of: contains process
type: TransitiveProperty
domain: occurrent
range: independent continuant
editor preferred term: occurs in
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
definition: a relation between a continuant and a process, in which the process takes place entirely within the independent continuant
editor note: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t

is gene of organism
type: ObjectProperty
definition: a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method.

inheres in
type: ObjectProperty
inverse of: bearer of
editor preferred term: inheres in
example of usage: this fragility inheres in this vase
example of usage: this red color inheres in this apple
definition: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
editor note: A dependent inheres in its bearer at all times for which the dependent exists.
has_exact_synonym: inheres_in

bearer of
type: ObjectProperty
range: specifically dependent continuant
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
has_exact_synonym: bearer_of
has_exact_synonym: is bearer of

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
editor preferred term: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
has_exact_synonym: participates_in

has participant
type: ObjectProperty
sub property of: topObjectProperty
domain: occurrent
range: continuant
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Example: Protein refolding process hasParticipant "GRP78/Bip" that has a chaperon role .
database_cross_reference: http://www.obofoundry.org/ro/#OBO_REL:has_participant

function of
type: ObjectProperty
sub property of: inheres in
inverse of: has function
domain: function
example of usage: this catalysis function is a function of this enzyme
definition: A relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
has_exact_synonym: function_of
has_exact_synonym: is_function_of

quality of
type: ObjectProperty
sub property of: inheres in
inverse of: has quality
example of usage: this red color is a quality of this apple
definition: a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
editor note: A quality inheres in its bearer at all times for which the quality exists.
has_exact_synonym: is quality of
has_exact_synonym: quality_of

role of
type: ObjectProperty
sub property of: inheres in
inverse of: has role
example of usage: this investigator role is a role of this person
definition: a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
editor note: A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
alternative term: is role of
alternative term: role_of

has function
type: ObjectProperty
sub property of: bearer of
range: function
definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
editor note: A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
database_cross_reference: hasQuality is a relation between an entity and the quality that it bears.
has_exact_synonym: has_quality

has role
type: ObjectProperty
sub property of: bearer of
range: role
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
has_exact_synonym: has_role
comment: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.

occurent part of
type: ObjectProperty
sub property of: part of
inverse of: has occurrent part
domain: occurrent
range: occurrent
has_exact_synonym: A part of relation that applies only between occurents.
has_exact_synonym: is occurent part of

supplies
type: ObjectProperty
definition: relation between an artery and the structure is supplies with blood

has component
type: ObjectProperty
sub property of: has part
inverse of: component of
definition: W 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.

regulates
type: ObjectProperty
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.

negatively regulates
type: ObjectProperty
sub property of: regulates
inverse of: negatively regulated by
type: TransitiveProperty
definition: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.

positively regulates
type: ObjectProperty
sub property of: regulates
inverse of: positively regulated by
definition: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
definition: P has output c iff c is a participant in p, c is present at the beginning of p.

has output
type: ObjectProperty
sub property of: has participant
inverse of: output of
definition: P has output c iff c is a participant in p, c is present at the end of p

regulated by
type: ObjectProperty
domain: process
range: process
definition: inverse of regulates: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.

negatively regulated by
type: ObjectProperty
sub property of: regulated by
domain: process
range: process
definition: inverse of negatively regulates: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.

positively regulated by
type: ObjectProperty
sub property of: regulated by
domain: process
range: process
definition: inverse of positively regulates: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.

has target start location
type: ObjectProperty
property chain axiom: part of
definition: This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.

has target end location
type: ObjectProperty
property chain axiom: part of
database_cross_reference: RO:0002339
database_cross_reference: This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination.

member of
type: ObjectProperty
sub property of: topObjectProperty
inverse of: has member
example of usage: An organism that is a member of a population of organisms
definition: is member of is a mereological relation between a item and a collection.
alternative term: is member of
alternative term: member part of
definition source: SIO

has member
type: ObjectProperty
sub property of: topObjectProperty
definition: has member is a mereological relation between a collection and an item.

input of
type: ObjectProperty
sub property of: participates in
definition: 'input of' is a relation between a participant and a process, where the participant is present at the start of the process.
has_exact_synonym: is input of

output of
type: ObjectProperty
sub property of: participates in
definition: 'output of' is a relation between a participant and a process, where the participant is present at the end of the process.
has_exact_synonym: is output of
has_exact_synonym: output_of

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.

composed_primarily_of
type: ObjectProperty
sub property of: has part
definition: x composed_primarily_of_y if:more than half of the mass of x is made from parts of y

causal relation between processes
type: ObjectProperty
sub property of: topObjectProperty
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
definition source: http://purl.obolibrary.org/obo/ro/docs/causal-relations

capable of regulating
type: ObjectProperty
sub property of: topObjectProperty
type: TransitiveProperty
range: Class
  union of: process
  union of: chemical entity
definition: Holds between c and p if and only if c is capable of some activity a, and a regulates p.

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
type: TransitiveProperty
range: process
definition: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
type: TransitiveProperty
range: process
definition: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.

has core process
type: ObjectProperty
sub property of: topObjectProperty
range: process
definition: a relation between a toxic course (the bearer) and a process. Core process is a crucial process to the manifestation of toxicity and depends on the bearer for its existence.
comment: has core process

metafuntioning type of
type: ObjectProperty
sub property of: quality of
inverse of: metafunctioning type
definition: 'Metafunctioning type of' is a relation between the type of metafunctioning and functioning process. Metafunctioning is a functional process to other process, for example, preventing, controlling and so on.
has_exact_synonym: is metafuntioning type of
has_exact_synonym: is_metafuntioning_type_of

has molecular reaction
type: ObjectProperty
sub property of: has occurrent part
inverse of: molecular reaction of
definition: 'has molecular reaction' is a relation that holds between a whole occurrent (process) and its molecular process.

finding of
type: ObjectProperty
sub property of: topObjectProperty
inverse of: has finding
definition: 'finding of' is a relation between a finding and an entity, where the finding is a representational artifact that a result of a laboratory test or an observation.
has_exact_synonym: is finding of

component of
type: ObjectProperty
sub property of: part of
definition: 'component of' is a relation between molecular components and a molecular complex.

located_in
type: ObjectProperty
sub property of: topObjectProperty
range: UBERON_0001062

has result
type: ObjectProperty
sub property of: causally downstream of or within
inverse of: has cause
type: TransitiveProperty
domain: process
range: process
definition: inverse of 'has cause': p 'has cause' q if p exerts some causal influence on q directly, where p is a cause and q is its effect.
has_exact_synonym: results in

has cause
type: ObjectProperty
sub property of: causally upstream of or within
domain: process
range: process
definition: p 'has cause' q if p exerts some causal influence on q directly, where p is a cause and q is its effect.

relation between a role and a process
type: ObjectProperty
definition: 'Relation between a role and a process' is a relationship that holds between a role of material entity and a process in which causality is involved, with either the material entity or some part of the material entity plays a role and some influence over the process.

manifested phenotype of
type: ObjectProperty
inverse of: manifests phenotype
definition: 'manifested phenotype of' is a relation between a phenotype and an entity, where there is a bearer of the realizable entity that participates in the process, and the phenotype comes to be realized in the course of the process.

manifests phenotype
type: ObjectProperty
type: TransitiveProperty
domain: process
example of usage: This shattering realizes the fragility in the course of breaking the cup (process).
definition: 'mainfests phenotype' is a relation between an entity and quality, where there is a bearer of the realizable entity that participates in the process, and the phenotype comes to be realized in the course of the process.

inherit
type: ObjectProperty
definition: Inherit means to receive a property (or an attribute and its value) from another entity (other than the ancestor) .

has family member
type: ObjectProperty
sub property of: has member
inverse of: family of
definition: 'has family member' is a relation between (molecule ) family and a molecule.
description: A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.

Axiom
annotated source: has family member
annotated property: description
annotated target: A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
database_cross_reference: Wikipedia:Protein family

dysfunctioning of
type: ObjectProperty
sub property of: malfunctioning of
inverse of: has dysfunctioning
range: TXPO_0000378
definition: 'dysfunctioning of' is a relation between an impaired or abnormal functioning and a normal functioning process.
has_exact_synonym: is dysfuctioning of

molecular reaction of
type: ObjectProperty
sub property of: occurent part of
definition: 'molecular reaction of' is a relation that holds between a molecular process and its whole process.
has_exact_synonym: is molecular reaction of
has_exact_synonym: molecular_reaction_of

relateds assay
type: ObjectProperty
sub property of: topObjectProperty
inverse of: related assay of
definition: 'relates assay' is a relation between an entity and the assay in which the entity was related (e.g., can be expressed, observed, and so on).

has context
type: ObjectProperty
inverse of: context of
type: TransitiveProperty
range: process
definition: 'has context' is a relation between an entity and its context dependent on. Role is intrinsically context-dependent.

has related human gene
type: ObjectProperty
definition: 'has related human gene' is a relation between a molecule and the related gene.

has attribute value
type: ObjectProperty
inverse of: attribute value of
domain: TXPO_0000300
range: TXPO_0000275
example of usage: The cross-sectional area of the coronary artery has attribute value 'small.'
definition: 'has attribute value' is a relation between an attribute and its value.

hyperfunction of
type: ObjectProperty
sub property of: malfunctioning of
definition: 'dysfunctioning of' is a relation between an increasing function process and a normal one.

malfunctioning of
type: ObjectProperty
definition: 'malfunctioning of' is a relation between an abnormal functioning and a normal functioning process.

has related rat gene
type: ObjectProperty

has state
type: ObjectProperty
sub property of: topObjectProperty
definition: 'has state' is a relation between an entity and the state.

has attribute
type: ObjectProperty
sub property of: has quality
inverse of: attribute of
domain: entity
range: TXPO_0000300
definition: 'has attribute' is a relation between an entity and its attribute, in which the attribute specifically depends on the bearer for its existence.

has agent
type: ObjectProperty
sub property of: has participant
inverse of: agent of
definition: 'has agent' is a relation between a participant and a process, in which the participant is active in the relevant process.
editor note: Example: A protease is an agent in proteolysis process.

metafunctioning type
type: ObjectProperty
sub property of: has quality
definition: Metafunctioning type is a relation between functional process and the type of metafunction. Metafunctioning is a functional process to other process, for example, preventing, controlling and so on.

property of
type: ObjectProperty
sub property of: quality of
definition: 'property of' is a relation between a property and the entity, , in which the property specifically depends on the bearer for its existence.
database_cross_reference: http://semanticscience.org/resource/SIO_000224
has_exact_synonym: is property of

attribute of
type: ObjectProperty
sub property of: quality of
definition: 'is attribute of' is a relation that associates an attribute with an entity.
has_exact_synonym: is attribute of
has_exact_synonym: is_attribute_of

has finding
type: ObjectProperty
sub property of: topObjectProperty
domain: process
range: TXPO_0001503
definition: 'has finding' is a relation between an entity and its finding, where the finding is a representational artifact that a result of a laboratory test or an observation.

context of
type: ObjectProperty
example of usage: Proteolysis is a context of the protease role of the molecule.
definition: 'context of' is a relation between a context and an entity. Role is intrinsically context-dependent.

related assay of
type: ObjectProperty
sub property of: topObjectProperty
definition: 'related assay of' is a relationship between an assay and the entity, in which the entity can be related (e.g., can be expressed, observed, and so on) in the assay like in vivo, in vitro or clinical test.

agent of
type: ObjectProperty
sub property of: participates in
definition: 'agent of' is a relation between a participant and a process, in which the participant is active in the relevant process.
has_exact_synonym: is agent of

family of
type: ObjectProperty
sub property of: member of
type: TransitiveProperty
definition: 'famly of' is a relationship between a molecule and its family.
description: A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
has_exact_synonym: family_of

Axiom
annotated source: family of
annotated property: description
annotated target: A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
database_cross_reference: Wikipedia:Protein family

has occurrent part
type: ObjectProperty
sub property of: has part
definition: "has ocurrent part" is a relation that holds between a whole occurrent (process) and its part.

has pathway
type: ObjectProperty
sub property of: has occurrent part
inverse of: pathway of
range: NCIT C54214
definition: "has pathway" is a relation that holds between a whole occurrent (process) for signaling and its pathway.

pathway of
type: ObjectProperty
sub property of: occurent part of
type: TransitiveProperty
definition: 'pathway of' is a relation that holds between a pathway and its whole (signaling) process.
has_exact_synonym: is pathway of
has_exact_synonym: is_pathway_of
has_exact_synonym: pathway_of

is entity in organism
type: ObjectProperty
domain: material entity
range: OBI_0100026
definition: 'Is substance in organism' is a relation between substance and organism where the substance is existed in.

has dysfunctioning
type: ObjectProperty
sub property of: topObjectProperty
range: TXPO_0000145
has_exact_synonym: 'has dysfunctioning' is a relation between a normal functioning process and an impaired or abnormal functioning.
has_exact_synonym: has_dysfunctioning

attribute value of
type: ObjectProperty
has_exact_synonym: 'Attribute value of' is a relation between a value and its attribute
has_exact_synonym: is attribute value of

observed in
type: ObjectProperty

realizes disease
type: ObjectProperty
range: disease
definition: A relation between a process/process sequence and a disease.

channel for
type: ObjectProperty
domain: UBERON_0004111
range: UBERON_0000463
definition: 'channel for' is a relation between a channel that is a passage and an entity such a solvent (e.g., ion) to pass.

entity
type: Class
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

Axiom
annotated source: entity
annotated property: editor note
annotated target: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000004
database_cross_reference: CeustersICbookRevised.pdf
comment: per discussion with Barry Smith

Axiom
annotated source: entity
annotated property: elucidation
annotated target: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/001-001

continuant
type: Class
subclass of: entity
disjoint with: occurrent
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

Axiom
annotated source: continuant
annotated property: editor note
annotated target: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000007

Axiom
annotated source: continuant
annotated property: elucidation
annotated target: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/011-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/011-002

occurrent
type: Class
subclass of: entity
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000006
comment: per discussion with Barry Smith

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000012

Axiom
annotated source: occurrent
annotated property: elucidation
annotated target: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/077-002

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/079-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/079-001

independent continuant
type: Class
subclass of: continuant
disjoint with: specifically dependent continuant
disjoint with: generically dependent continuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]

Axiom
annotated source: independent continuant
annotated property: definition
annotated target: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/017-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/017-002

spatial region
type: Class
subclass of: immaterial entity
disjoint with: site
disjoint with: continuant fiat boundary
editor note: BFO 2 Reference: Spatial regions do not participate in processes.
editor note: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
elucidation: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has associated axiom(nl): All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has associated axiom(fol): (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has associated axiom(fol): (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]

Axiom
annotated source: spatial region
annotated property: editor note
annotated target: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000002
comment: per discussion with Barry Smith

Axiom
annotated source: spatial region
annotated property: elucidation
annotated target: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/035-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(nl)
annotated target: All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/035-001

temporal region
type: Class
subclass of: occurrent
disjoint with: spatiotemporal region
disjoint with: process
disjoint with: process boundary
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

Axiom
annotated source: temporal region
annotated property: editor note
annotated target: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000003
comment: per discussion with Barry Smith

Axiom
annotated source: temporal region
annotated property: elucidation
annotated target: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/100-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/100-001

two-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
example of usage: an infinitely thin plane in space.
example of usage: the surface of a sphere-shaped part of space
elucidation: A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
has associated axiom(fol): (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]

Axiom
annotated source: two-dimensional spatial region
annotated property: elucidation
annotated target: A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/039-001

Axiom
annotated source: two-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/039-001

spatiotemporal region
type: Class
subclass of: occurrent
example of usage: the spatiotemporal region occupied by a human life
example of usage: the spatiotemporal region occupied by a process of cellular meiosis.
example of usage: the spatiotemporal region occupied by the development of a cancer tumor
elucidation: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
has associated axiom(nl): All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
has associated axiom(nl): Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
has associated axiom(nl): Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
has associated axiom(nl): Every spatiotemporal region occupies_spatiotemporal_region itself.
has associated axiom(nl): Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
has associated axiom(fol): (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
has associated axiom(fol): (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
has associated axiom(fol): (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]

Axiom
annotated source: spatiotemporal region
annotated property: elucidation
annotated target: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/095-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/096-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/099-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/098-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/107-002

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/107-002

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/099-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/096-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/095-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/098-001

process
type: Class
subclass of: occurrent
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the life of an organism
example of usage: your process of aging.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
curator note: Superclass of unit process(primitive process) and senquence processes. It is dissective and has no unity, and hence it can change. It follows A-series of time.
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]

Axiom
annotated source: process
annotated property: definition
annotated target: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/083-003

Axiom
annotated source: process
annotated property: curator note
annotated target: Superclass of unit process(primitive process) and senquence processes. It is dissective and has no unity, and hence it can change. It follows A-series of time.
database_cross_reference: YAMATO ontology

Axiom
annotated source: process
annotated property: has associated axiom(fol)
annotated target: (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/083-003

disposition
type: Class
subclass of: realizable entity
disjoint with: role
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

Axiom
annotated source: disposition
annotated property: elucidation
annotated target: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/062-002

Axiom
annotated source: disposition
annotated property: has associated axiom(nl)
annotated target: If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/062-002

realizable entity
type: Class
subclass of: specifically dependent continuant
disjoint with: quality
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

Axiom
annotated source: realizable entity
annotated property: elucidation
annotated target: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/058-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(nl)
annotated target: All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/058-002

zero-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
elucidation: A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]

Axiom
annotated source: zero-dimensional spatial region
annotated property: elucidation
annotated target: A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/037-001

Axiom
annotated source: zero-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/037-001

quality
type: Class
subclass of: specifically dependent continuant
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
database_cross_reference: YAMATO:property

Axiom
annotated source: quality
annotated property: elucidation
annotated target: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/055-001

Axiom
annotated source: quality
annotated property: has associated axiom(nl)
annotated target: If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/105-001

Axiom
annotated source: quality
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/055-001

Axiom
annotated source: quality
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/105-001

specifically dependent continuant
type: Class
subclass of: continuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]

Axiom
annotated source: specifically dependent continuant
annotated property: definition
annotated target: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/050-003

Axiom
annotated source: specifically dependent continuant
annotated property: editor note
annotated target: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000005
comment: per discussion with Barry Smith

Axiom
annotated source: specifically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/050-003

role
type: Class
subclass of: realizable entity
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

Axiom
annotated source: role
annotated property: elucidation
annotated target: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/061-001

Axiom
annotated source: role
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/061-001

fiat object part
type: Class
subclass of: material entity
example of usage: or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
example of usage: the FMA:regional parts of an intact human body.
example of usage: the Western hemisphere of the Earth
example of usage: the division of the brain into regions
example of usage: the division of the planet into hemispheres
example of usage: the dorsal and ventral surfaces of the body
example of usage: the upper and lower lobes of the left lung
editor note: BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
elucidation: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has associated axiom(fol): (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]

Axiom
annotated source: fiat object part
annotated property: elucidation
annotated target: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/027-004

Axiom
annotated source: fiat object part
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/027-004

one-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
example of usage: an edge of a cube-shaped portion of space.
elucidation: A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]

Axiom
annotated source: one-dimensional spatial region
annotated property: elucidation
annotated target: A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/038-001

Axiom
annotated source: one-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/038-001

object aggregate
type: Class
subclass of: material entity
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000011

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000301

Axiom
annotated source: object aggregate
annotated property: definition source
annotated target: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000300

Axiom
annotated source: object aggregate
annotated property: elucidation
annotated target: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/025-004

Axiom
annotated source: object aggregate
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/025-004

three-dimensional spatial region
type: Class
subclass of: spatial region
example of usage: a cube-shaped region of space
example of usage: a sphere-shaped region of space,
elucidation: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
has associated axiom(fol): (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]

Axiom
annotated source: three-dimensional spatial region
annotated property: elucidation
annotated target: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/040-001

Axiom
annotated source: three-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/040-001

site
type: Class
subclass of: immaterial entity
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

Axiom
annotated source: site
annotated property: elucidation
annotated target: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/034-002

Axiom
annotated source: site
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/034-002

object
type: Class
subclass of: material entity
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])

Axiom
annotated source: object
annotated property: elucidation
annotated target: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/024-001

generically dependent continuant
type: Class
subclass of: continuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]

Axiom
annotated source: generically dependent continuant
annotated property: definition
annotated target: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/074-001

Axiom
annotated source: generically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/074-001

function
type: Class
subclass of: disposition
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

Axiom
annotated source: function
annotated property: elucidation
annotated target: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/064-001

Axiom
annotated source: function
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/064-001

process boundary
type: Class
subclass of: occurrent
example of usage: the boundary between the 2nd and 3rd year of your life.
definition: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
has associated axiom(nl): Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
has associated axiom(fol): (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
has associated axiom(fol): (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/085-002

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/084-001

Axiom
annotated source: process boundary
annotated property: definition
annotated target: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/084-001

Axiom
annotated source: process boundary
annotated property: has associated axiom(nl)
annotated target: Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/085-002

one-dimensional temporal region
type: Class
subclass of: temporal region
disjoint with: zero-dimensional temporal region
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

Axiom
annotated source: one-dimensional temporal region
annotated property: elucidation
annotated target: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/103-001

Axiom
annotated source: one-dimensional temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/103-001

material entity
type: Class
subclass of: independent continuant
disjoint with: immaterial entity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]

Axiom
annotated source: material entity
annotated property: elucidation
annotated target: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/020-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/020-002

continuant fiat boundary
type: Class
subclass of: immaterial entity
definition: b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
editor note: BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions.
editor note: BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29
editor note: Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
has associated axiom(nl): Every continuant fiat boundary is located at some spatial region at every time at which it exists
has associated axiom(fol): (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]

Axiom
annotated source: continuant fiat boundary
annotated property: definition
annotated target: b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/029-001

Axiom
annotated source: continuant fiat boundary
annotated property: editor note
annotated target: Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000008

Axiom
annotated source: continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/029-001

immaterial entity
type: Class
subclass of: independent continuant
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10

one-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
disjoint with: two-dimensional continuant fiat boundary
disjoint with: zero-dimensional continuant fiat boundary
example of usage: The Equator
example of usage: all geopolitical boundaries
example of usage: all lines of latitude and longitude
example of usage: the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin.
example of usage: the median sulcus of your tongue
elucidation: a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
has associated axiom(fol): (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]

Axiom
annotated source: one-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/032-001

Axiom
annotated source: one-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/032-001

process profile
type: Class
subclass of: process
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

Axiom
annotated source: process profile
annotated property: definition
annotated target: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/093-002

Axiom
annotated source: process profile
annotated property: elucidation
annotated target: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/093-002

relational quality
type: Class
subclass of: quality
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: a marriage bond, an instance of love, an obligation between one person and another.
definition: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
has associated axiom(fol): (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]

Axiom
annotated source: relational quality
annotated property: definition
annotated target: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/057-001

Axiom
annotated source: relational quality
annotated property: has associated axiom(fol)
annotated target: (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/057-001

two-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
elucidation: a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
has associated axiom(fol): (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]

Axiom
annotated source: two-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/033-001

Axiom
annotated source: two-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/033-001

zero-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
example of usage: the geographic North Pole
example of usage: the point of origin of some spatial coordinate system.
example of usage: the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet
editor note: zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
elucidation: a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
has associated axiom(fol): (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: editor note
annotated target: zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/0000001
database_cross_reference: ZDRnpiIi TUJ
comment: requested by Melanie Courtot

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/031-001

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/031-001

zero-dimensional temporal region
type: Class
subclass of: temporal region
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

Axiom
annotated source: zero-dimensional temporal region
annotated property: elucidation
annotated target: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/102-001

Axiom
annotated source: zero-dimensional temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]
has axiom label: http://purl.obolibrary.org/obo/bfo/axiom/102-001

voriconazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: P450 inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
database_cross_reference: Beilstein:7694998
database_cross_reference: CAS:137234-62-9
database_cross_reference: DrugBank:DB00582
database_cross_reference: Drug_Central:2846
database_cross_reference: LINCS:LSM-5244
database_cross_reference: PMID:12940129
database_cross_reference: PMID:22718362
database_cross_reference: PMID:23392902
database_cross_reference: PMID:23527908
database_cross_reference: PMID:23766489
database_cross_reference: PMID:24102553
has_exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
has_exact_synonym: voriconazole
has_related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
has_related_synonym: (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
has_related_synonym: VCZ
has_related_synonym: Vfend
has_related_synonym: voriconazol
has_related_synonym: voriconazole
has_related_synonym: voriconazolum
id: CHEBI:10023

Beilstein
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: Beilstein:7694998

ChemIDplus
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: CAS:137234-62-9

DrugBank
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: CAS:137234-62-9

DrugCentral
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: Drug_Central:2846

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:12940129

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:22718362

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:23392902

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:23527908

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:23766489

Europe PMC
type: Axiom
annotated source: voriconazole
annotated property: database_cross_reference
annotated target: PMID:24102553

ciprofloxacin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
subclass of: Restriction
  on property: has role
  some values from: topoisomerase IV inhibitor
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
database_cross_reference: Beilstein:3568352
database_cross_reference: CAS:85721-33-1
database_cross_reference: DrugBank:DB00537
database_cross_reference: Drug_Central:659
database_cross_reference: LINCS:LSM-5226
database_cross_reference: PMID:10397494
database_cross_reference: PMID:10737746
database_cross_reference: Reaxys:3568352
has_exact_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
has_exact_synonym: Ciprofloxacin
has_exact_synonym: ciprofloxacin
has_related_synonym: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
has_related_synonym: 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
has_related_synonym: 1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
has_related_synonym: ciprofloxacin
has_related_synonym: ciprofloxacine
has_related_synonym: ciprofloxacino
has_related_synonym: ciprofloxacinum
id: CHEBI:100241

Beilstein
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: Beilstein:3568352

ChemIDplus
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: CAS:85721-33-1

DrugCentral
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: Drug_Central:659

ChEMBL
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: PMID:10397494

ChEMBL
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: PMID:10737746

Reaxys
type: Axiom
annotated source: ciprofloxacin
annotated property: database_cross_reference
annotated target: Reaxys:3568352

zafirlukast
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: leukotriene antagonist
subclass of: Restriction
  on property: has role
  some values from: anti-asthmatic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:3641829
database_cross_reference: CAS:107753-78-6
database_cross_reference: DrugBank:DB00549
database_cross_reference: Drug_Central:2855
database_cross_reference: LINCS:LSM-5792
database_cross_reference: PMID:11888331
database_cross_reference: PMID:19331987
database_cross_reference: PMID:22159431
database_cross_reference: PMID:22614107
database_cross_reference: PMID:24258705
database_cross_reference: PMID:25798389
database_cross_reference: PMID:25834030
database_cross_reference: Reaxys:3641829
has_exact_synonym: cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
has_related_synonym: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
has_related_synonym: Accolate
has_related_synonym: cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate
has_related_synonym: zafirlukast
id: CHEBI:10100

Beilstein
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: Beilstein:3641829

ChemIDplus
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: CAS:107753-78-6

DrugCentral
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: Drug_Central:2855

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:11888331

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:19331987

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:22159431

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:22614107

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:24258705

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:25798389

Europe PMC
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: PMID:25834030

Reaxys
type: Axiom
annotated source: zafirlukast
annotated property: database_cross_reference
annotated target: Reaxys:3641829

zidovudine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
formula: C10H13N5O4
smiles: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
database_cross_reference: Beilstein:763034
database_cross_reference: CAS:30516-87-1
database_cross_reference: DrugBank:DB00495
database_cross_reference: Drug_Central:2861
database_cross_reference: LINCS:LSM-5806
database_cross_reference: PMID:19112024
database_cross_reference: PMID:26859826
database_cross_reference: PMID:29438107
database_cross_reference: PMID:9203666
database_cross_reference: Wikipedia:Zidovudine
has_exact_synonym: 3'-azido-3'-deoxythymidine
has_exact_synonym: AZT
has_related_synonym: AZT
has_related_synonym: Azidothymidine
has_related_synonym: Retrovir
has_related_synonym: Zidovudin
has_related_synonym: Zidovudinum
has_related_synonym: zidovudine
id: CHEBI:10110

Beilstein
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: Beilstein:763034

ChemIDplus
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: CAS:30516-87-1

DrugBank
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: CAS:30516-87-1

DrugCentral
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: Drug_Central:2861

ChEMBL
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: PMID:19112024

Europe PMC
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: PMID:26859826

Europe PMC
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: PMID:29438107

Europe PMC
type: Axiom
annotated source: zidovudine
annotated property: database_cross_reference
annotated target: PMID:9203666

zileuton
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: leukotriene antagonist
subclass of: Restriction
  on property: has role
  some values from: anti-asthmatic drug
subclass of: Restriction
  on property: has role
  some values from: EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
database_cross_reference: CAS:111406-87-2
database_cross_reference: DrugBank:DB00744
database_cross_reference: Drug_Central:2862
database_cross_reference: LINCS:LSM-5084
database_cross_reference: PMID:19309543
database_cross_reference: PMID:19645854
database_cross_reference: PMID:20204486
database_cross_reference: PMID:20436887
has_exact_synonym: 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
has_exact_synonym: Zileuton
has_related_synonym: (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
has_related_synonym: Leutrol
has_related_synonym: N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
has_related_synonym: N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
has_related_synonym: Zyflo
has_related_synonym: zileuton
has_related_synonym: zileutonum
id: CHEBI:10112

ChemIDplus
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: CAS:111406-87-2

DrugCentral
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: Drug_Central:2862

Europe PMC
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: PMID:19309543

Europe PMC
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: PMID:19645854

Europe PMC
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: PMID:20204486

Europe PMC
type: Axiom
annotated source: zileuton
annotated property: database_cross_reference
annotated target: PMID:20436887

diltiazem
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: vasodilator agent
subclass of: Restriction
  on property: has role
  some values from: antihypertensive agent
subclass of: Restriction
  on property: has role
  some values from: calcium channel blocker
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
database_cross_reference: Beilstein:3573079
database_cross_reference: CAS:42399-41-7
database_cross_reference: DrugBank:DB00343
database_cross_reference: Drug_Central:897
database_cross_reference: LINCS:LSM-2523
database_cross_reference: PMID:11937779
database_cross_reference: PMID:16651034
database_cross_reference: PMID:19167257
database_cross_reference: PMID:23687551
database_cross_reference: PMID:24261918
database_cross_reference: PMID:25122162
database_cross_reference: PMID:8369596
database_cross_reference: Reaxys:3573079
has_exact_synonym: (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
has_related_synonym: (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
has_related_synonym: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
has_related_synonym: (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
has_related_synonym: Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
has_related_synonym: D-cis-diltiazem
has_related_synonym: d-cis-diltiazem
has_related_synonym: diltiazem
has_related_synonym: diltiazemum
id: CHEBI:101278

Beilstein
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: Beilstein:3573079

ChemIDplus
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: CAS:42399-41-7

NIST Chemistry WebBook
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: CAS:42399-41-7

DrugCentral
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: Drug_Central:897

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:11937779

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:16651034

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:19167257

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:23687551

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:24261918

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:25122162

Europe PMC
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: PMID:8369596

Reaxys
type: Axiom
annotated source: diltiazem
annotated property: database_cross_reference
annotated target: Reaxys:3573079

erlotinib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: protein kinase inhibitor
subclass of: Restriction
  on property: has role
  some values from: epidermal growth factor receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.
database_cross_reference: CAS:183321-74-6
database_cross_reference: DrugBank:DB00530
database_cross_reference: Drug_Central:1045
database_cross_reference: LINCS:LSM-1097
database_cross_reference: PMID:12270171
database_cross_reference: PMID:14684309
database_cross_reference: PMID:15711537
database_cross_reference: PMID:16014882
database_cross_reference: PMID:16014883
database_cross_reference: PMID:16480284
database_cross_reference: PMID:17889528
database_cross_reference: PMID:17983745
database_cross_reference: PMID:29448920
database_cross_reference: PMID:29579331
database_cross_reference: PMID:29687154
database_cross_reference: PMID:30039303
database_cross_reference: PMID:30071517
database_cross_reference: PMID:30150014
database_cross_reference: PMID:30158288
database_cross_reference: Reaxys:8798958
has_exact_synonym: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
has_related_synonym: [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine
has_related_synonym: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine
has_related_synonym: erlotinib
has_related_synonym: erlotinibum
id: CHEBI:114785

ChemIDplus
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: CAS:183321-74-6

DrugBank
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: CAS:183321-74-6

DrugCentral
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: Drug_Central:1045

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:12270171

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:14684309

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:15711537

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:16014882

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:16014883

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:16480284

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:17889528

ChEMBL
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:17983745

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:29448920

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:29579331

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:29687154

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:30039303

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:30071517

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:30150014

Europe PMC
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: PMID:30158288

Reaxys
type: Axiom
annotated source: erlotinib
annotated property: database_cross_reference
annotated target: Reaxys:8798958

nomifensine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: dopamine uptake inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
database_cross_reference: Beilstein:484561
database_cross_reference: CAS:24526-64-5
database_cross_reference: DrugBank:DB04821
database_cross_reference: Drug_Central:1958
database_cross_reference: LINCS:LSM-4388
database_cross_reference: PMID:1502708
database_cross_reference: PMID:24766210
database_cross_reference: PMID:7189402
database_cross_reference: Reaxys:484561
has_exact_synonym: 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
has_exact_synonym: Nomifensine
has_related_synonym: (+-)-Nomifensin
has_related_synonym: (+-)-Nomifensine
has_related_synonym: 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
has_related_synonym: 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
has_related_synonym: D,L-nomifensine
has_related_synonym: Nomifenison
has_related_synonym: Nomifensin
has_related_synonym: Nomiphensine
has_related_synonym: R/S-nomifensine
has_related_synonym: nomifensina
has_related_synonym: nomifensine
has_related_synonym: nomifensinum
id: CHEBI:116225

Beilstein
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: Beilstein:484561

ChemIDplus
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: CAS:24526-64-5

NIST Chemistry WebBook
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: CAS:24526-64-5

DrugCentral
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: Drug_Central:1958

Europe PMC
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: PMID:1502708

Europe PMC
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: PMID:24766210

Europe PMC
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: PMID:7189402

Reaxys
type: Axiom
annotated source: nomifensine
annotated property: database_cross_reference
annotated target: Reaxys:484561

efavirenz
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.
database_cross_reference: Beilstein:7387333
database_cross_reference: CAS:154598-52-4
database_cross_reference: DrugBank:DB00625
database_cross_reference: Drug_Central:989
database_cross_reference: LINCS:LSM-5526
database_cross_reference: PMID:10576692
database_cross_reference: PMID:10673109
database_cross_reference: PMID:25017682
database_cross_reference: Reaxys:7387333
has_exact_synonym: (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
has_exact_synonym: Efavirenz
has_related_synonym: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
has_related_synonym: (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
has_related_synonym: (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
has_related_synonym: 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
id: CHEBI:119486

Beilstein
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: Beilstein:7387333

ChemIDplus
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: CAS:154598-52-4

DrugCentral
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: Drug_Central:989

ChEMBL
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: PMID:10576692

ChEMBL
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: PMID:10673109

Europe PMC
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: PMID:25017682

Reaxys
type: Axiom
annotated source: efavirenz
annotated property: database_cross_reference
annotated target: Reaxys:7387333

atomoxetine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: adrenergic uptake inhibitor
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.
database_cross_reference: Beilstein:4318684
database_cross_reference: CAS:83015-26-3
database_cross_reference: DrugBank:DB00289
database_cross_reference: Drug_Central:256
database_cross_reference: LINCS:LSM-2452
database_cross_reference: PMID:15338851
database_cross_reference: PMID:23048018
database_cross_reference: Reaxys:4318684
has_exact_synonym: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
has_related_synonym: (-)-Tomoxetine
has_related_synonym: Tomoxetina
has_related_synonym: Tomoxetinum
has_related_synonym: atomoxetine
has_related_synonym: tomoxetine
id: CHEBI:127342

Beilstein
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: Beilstein:4318684

ChemIDplus
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: CAS:83015-26-3

DrugCentral
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: Drug_Central:256

Europe PMC
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: PMID:15338851

Europe PMC
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: PMID:23048018

Reaxys
type: Axiom
annotated source: atomoxetine
annotated property: database_cross_reference
annotated target: Reaxys:4318684

lysophosphatidic acid
type: Class
subclass of: lysophosphatidic acids
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003686
definition: A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class.
database_cross_reference: MeSH:C032881
database_cross_reference: PMID:20118541 Lysophosphatidic acid (LPA) is a lipid mediator that is known to exhibit chemotactic activity toward a variety of cancer cells. However, its effect on the immune system has not been studied extensively. Another lipid mediator, sphingosine-1-phosphate (S1P), has been shown to influence lymphocyte recirculation by regulating lymphocyte egress from lymphoid organs. In this study, we found that LPA inhibits spontaneous migration of mouse splenic lymphocytes through a chemorepulsive effect. We also demonstrated that LPA inhibits chemokine CCL21-induced lymphocyte migration. This inhibitory effect on CCL21-induced migration was observed for both T and B cells. The involvement of a receptor, LPA(1), LPA(2) or LPA(3), in the inhibition of the CCL21-induced migration was confirmed with a synthetic agonist, oleyl thiophosphate. Considering that the signaling by CCL21 through cognate receptor CCR7 contributes to lymphocyte homing and dendritic cell trafficking to lymph nodes, LPA may play a role as a key regulator of these processes. The inhibitory effect of LPA is in remarkable contrast to the effect of S1P receptor signaling, which is known to potentiate lymphocyte chemotaxis involving CCR7.
database_cross_reference: PMID:7768880 Lysophosphatidic acid, a multifunctional phospholipid messenger. Lysophosphatidic acid (LPA1(1); 1-acyl-glycerol-3-phosphate),is the simplest of all glycerophospholipids. While LPA has long been known as a precursor of phospholipid biosynthesis in both eukaryotic and prokaryotic cells, only recently has LPA emerged as an intercellular signaling molecule that is rapidly produced and released by activated cells, notably platelets, to influence target cells by acting on a specific cell-surface receptor. The list of biological responses to LPA is quite diverse, ranging from induction of cell proliferation to stimulation of neurite retraction. The mitogenic activities of LPA have been best studied in fibroblasts. As with peptide growth factors, induction of DNA synthesis by LPA requires its long term presence in the medium LPA, but not peptide growth factors, can mimic serum in inducing invasion of carcinoma and hepatoma cells into monolayers of mesothelial cells. The underlying mechanism is not clear but may well involve both increased cell adhesion and enhanced cell motility. Many mitogens activate the p85/p110 phosphatidylinositol (PI) 3-kinase in their target cells and so does LPA. LPA-induced PI 3-kinase activity has been found in 3T3 cells (Ref. 44; but see ref. 45 for conflicting data) and in megakaryoblastic cells. Whatever its precise link to the LPA receptor and physiological function, PI 3-kinase does not seem to be essential for mitogenic signaling, since microinjection of a neutralizing antibody does not affect LPA-induced DNA synthesis.
has_exact_synonym: LPA

intermediate-density lipoprotein
type: Class
subclass of: lipoprotein
definition: A class of lipoproteins with a density between that of low-density and very-low-density lipoproteins. They are formed by the degradatiion of very-low-density lipoproteins.
has_related_synonym: IDL

farnesoid X receptor agonist
type: Class
subclass of: agonist
definition: An agonist that binds to and activates farnesoid X receptors
database_cross_reference: Wikipedia:Farnesoid_X_receptor
has_related_synonym: BAR agonist
has_related_synonym: FXR agonist
has_related_synonym: bile acid receptor agonist

radiosensitizing agent
type: Class
subclass of: drug
definition: A drug that makes increases the sensitivity of tumour cells to radiation therapy.
database_cross_reference: PMID:12520460
has_related_synonym: radiosensitiser
has_related_synonym: radiosensitisers
has_related_synonym: radiosensitising agent
has_related_synonym: radiosensitising agents
has_related_synonym: radiosensitizer
has_related_synonym: radiosensitizers
has_related_synonym: radiosensitizing agents
id: CHEBI:132992

Europe PMC
type: Axiom
annotated source: radiosensitizing agent
annotated property: database_cross_reference
annotated target: PMID:12520460

fatty acid oxidation inhibitor
type: Class
subclass of: TXPO_0003648
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: fatty acid oxidation
definition: A role played by the entity which inhibits the oxidation of any fatty acid.

NAD
type: Class
subclass of: nucleotide
definition: Abbreviation for nicotinamide-adenine dinucleotide when its oxidation state is unknown or unspecified. It is used in metabolic pathways like glycolysis and citric acid cycle.
database_cross_reference: Wikipedia:Nicotinamide_adenine_dinucleotide

mebanazine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:65-64-5
database_cross_reference: Drug_Central:4865
has_related_synonym: ICI-31397
has_related_synonym: actomol
has_related_synonym: mebanazine hydrochloride
has_related_synonym: mebanazine monohydrochloride
has_related_synonym: mebanazine monooxalate
has_related_synonym: mebanazine monosulfate
has_related_synonym: mebanazine oxalate
has_related_synonym: mebanazine sulfate
id: CHEBI:134728

DrugCentral
type: Axiom
annotated source: mebanazine
annotated property: database_cross_reference
annotated target: CAS:65-64-5

DrugCentral
type: Axiom
annotated source: mebanazine
annotated property: database_cross_reference
annotated target: Drug_Central:4865

isaxonine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:4214-72-6
database_cross_reference: Drug_Central:1485
has_related_synonym: N-(Isopropylamino)-2-pyrimidine
id: CHEBI:134762

DrugCentral
type: Axiom
annotated source: isaxonine
annotated property: database_cross_reference
annotated target: CAS:4214-72-6

DrugCentral
type: Axiom
annotated source: isaxonine
annotated property: database_cross_reference
annotated target: Drug_Central:1485

sulfacarbamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:547-44-4
database_cross_reference: Drug_Central:2496
has_related_synonym: sulfanilcarbamid
has_related_synonym: sulfanilylurea
has_related_synonym: sulfaurea
has_related_synonym: sulphacarbamide
has_related_synonym: sulphaurea
has_related_synonym: urosulfan
has_related_synonym: urosulfane
id: CHEBI:134891

DrugCentral
type: Axiom
annotated source: sulfacarbamide
annotated property: database_cross_reference
annotated target: CAS:547-44-4

DrugCentral
type: Axiom
annotated source: sulfacarbamide
annotated property: database_cross_reference
annotated target: Drug_Central:2496

tilbroquinol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:7175-09-9
database_cross_reference: Drug_Central:2662
has_related_synonym: 5-Methyl-7-bromo-8-hydroxyquinoline
id: CHEBI:134965

DrugCentral
type: Axiom
annotated source: tilbroquinol
annotated property: database_cross_reference
annotated target: CAS:7175-09-9

DrugCentral
type: Axiom
annotated source: tilbroquinol
annotated property: database_cross_reference
annotated target: Drug_Central:2662

milnacipran
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:92623-85-3
database_cross_reference: Drug_Central:1808
has_related_synonym: (+/-)-Milnacipran
has_related_synonym: midalcipran
has_related_synonym: milnacipran HCl
has_related_synonym: milnacipran hydrochloride
id: CHEBI:135005

DrugCentral
type: Axiom
annotated source: milnacipran
annotated property: database_cross_reference
annotated target: CAS:92623-85-3

DrugCentral
type: Axiom
annotated source: milnacipran
annotated property: database_cross_reference
annotated target: Drug_Central:1808

nitrefazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:21721-92-6
database_cross_reference: Drug_Central:1946
has_related_synonym: altimol
id: CHEBI:135009

DrugCentral
type: Axiom
annotated source: nitrefazole
annotated property: database_cross_reference
annotated target: CAS:21721-92-6

DrugCentral
type: Axiom
annotated source: nitrefazole
annotated property: database_cross_reference
annotated target: Drug_Central:1946

pirprofen
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID) that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis and pain. (by Wikipedia)
formula: C13H14ClNO2
smiles: ClC1=C(C=CC(=C1)C(C(O)=O)C)N2CC=CC2
database_cross_reference: CAS:31793-07-4
database_cross_reference: DrugBank:DB13722
database_cross_reference: Drug_Central:2213
database_cross_reference: Wikipedia:Pirprofen
has_related_synonym: racemic pirprofen
has_related_synonym: rengasil
id: CHEBI:135028

DrugCentral
type: Axiom
annotated source: pirprofen
annotated property: database_cross_reference
annotated target: CAS:31793-07-4

DrugCentral
type: Axiom
annotated source: pirprofen
annotated property: database_cross_reference
annotated target: Drug_Central:2213

clomacran
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:5310-55-4
database_cross_reference: Drug_Central:3717
has_related_synonym: clomacran phosphate
id: CHEBI:135273

DrugCentral
type: Axiom
annotated source: clomacran
annotated property: database_cross_reference
annotated target: CAS:5310-55-4

DrugCentral
type: Axiom
annotated source: clomacran
annotated property: database_cross_reference
annotated target: Drug_Central:3717

zimeldine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:56775-88-3
database_cross_reference: Drug_Central:2863
has_related_synonym: cis-Zimelidine
has_related_synonym: zimeldine hydrochloride hydrate
has_related_synonym: zimelidine
has_related_synonym: zimelidine HCl
has_related_synonym: zimelidine dihydrochloride
has_related_synonym: zimelidine dihydrochloride hydrate
has_related_synonym: zimelidine dihydrochloride monohydrate
has_related_synonym: zimelidine hydrochloride
id: CHEBI:135357

DrugCentral
type: Axiom
annotated source: zimeldine
annotated property: database_cross_reference
annotated target: CAS:56775-88-3

DrugCentral
type: Axiom
annotated source: zimeldine
annotated property: database_cross_reference
annotated target: Drug_Central:2863

oxyphenisatine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:125-13-3
database_cross_reference: Drug_Central:2038
has_related_synonym: oxyphenisatin
has_related_synonym: phenolisatin
has_related_synonym: veripaque
id: CHEBI:135358

DrugCentral
type: Axiom
annotated source: oxyphenisatine
annotated property: database_cross_reference
annotated target: CAS:125-13-3

DrugCentral
type: Axiom
annotated source: oxyphenisatine
annotated property: database_cross_reference
annotated target: Drug_Central:2038

clometacin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:25803-14-9
database_cross_reference: Drug_Central:698
has_related_synonym: clometacine
has_related_synonym: clometazin
has_related_synonym: clomethacin
has_related_synonym: duperan
has_related_synonym: mindolic acid
id: CHEBI:135512

DrugCentral
type: Axiom
annotated source: clometacin
annotated property: database_cross_reference
annotated target: CAS:25803-14-9

DrugCentral
type: Axiom
annotated source: clometacin
annotated property: database_cross_reference
annotated target: Drug_Central:698

pipamazine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:84-04-8
database_cross_reference: Drug_Central:2180
has_related_synonym: mornidine
has_related_synonym: nausidol
has_related_synonym: nometine
id: CHEBI:135641

DrugCentral
type: Axiom
annotated source: pipamazine
annotated property: database_cross_reference
annotated target: CAS:84-04-8

DrugCentral
type: Axiom
annotated source: pipamazine
annotated property: database_cross_reference
annotated target: Drug_Central:2180

alpidem
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anxiolytic drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
formula: C21H23Cl2N3O
database_cross_reference: CAS:82626-01-5
database_cross_reference: Drug_Central:134
database_cross_reference: Wikipedia:Alpidem
has_exact_synonym: Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family, related to the more well known sleeping medication zolpidem. (by Wikipedia)
has_exact_synonym: Ananxyl
has_related_synonym: ananxyl
id: CHEBI:135649

DrugCentral
type: Axiom
annotated source: alpidem
annotated property: database_cross_reference
annotated target: CAS:82626-01-5

DrugCentral
type: Axiom
annotated source: alpidem
annotated property: database_cross_reference
annotated target: Drug_Central:134

tasosartan
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:145733-36-4
database_cross_reference: Drug_Central:3839
has_related_synonym: ANA-756
has_related_synonym: ANA756
has_related_synonym: verdia
id: CHEBI:135666

DrugCentral
type: Axiom
annotated source: tasosartan
annotated property: database_cross_reference
annotated target: CAS:145733-36-4

DrugCentral
type: Axiom
annotated source: tasosartan
annotated property: database_cross_reference
annotated target: Drug_Central:3839

niperotidine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:84845-75-0
database_cross_reference: Drug_Central:4002
has_related_synonym: niperotidine HCl
has_related_synonym: niperotidine hydrochloride
has_related_synonym: perultid
has_related_synonym: piperonyl ranitidine HCl
has_related_synonym: piperonyl ranitidine hydrochloride
id: CHEBI:135706

DrugCentral
type: Axiom
annotated source: niperotidine
annotated property: database_cross_reference
annotated target: CAS:84845-75-0

DrugCentral
type: Axiom
annotated source: niperotidine
annotated property: database_cross_reference
annotated target: Drug_Central:4002

ebrotidine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:100981-43-9
database_cross_reference: Drug_Central:979
has_related_synonym: FI-3542
has_related_synonym: ebrodin
has_related_synonym: ulsanic
id: CHEBI:135774

DrugCentral
type: Axiom
annotated source: ebrotidine
annotated property: database_cross_reference
annotated target: CAS:100981-43-9

DrugCentral
type: Axiom
annotated source: ebrotidine
annotated property: database_cross_reference
annotated target: Drug_Central:979

benziodarone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:68-90-6
database_cross_reference: Drug_Central:321
has_related_synonym: cardivix
has_related_synonym: dilafurane
id: CHEBI:135814

DrugCentral
type: Axiom
annotated source: benziodarone
annotated property: database_cross_reference
annotated target: CAS:68-90-6

DrugCentral
type: Axiom
annotated source: benziodarone
annotated property: database_cross_reference
annotated target: Drug_Central:321

alatrofloxacin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:146961-76-4
database_cross_reference: Drug_Central:102
has_related_synonym: alatrofloxacin mesilate
has_related_synonym: alatrofloxacin mesylate
id: CHEBI:135829

DrugCentral
type: Axiom
annotated source: alatrofloxacin
annotated property: database_cross_reference
annotated target: CAS:146961-76-4

DrugCentral
type: Axiom
annotated source: alatrofloxacin
annotated property: database_cross_reference
annotated target: Drug_Central:102

glycerophosphonocholine
type: Class
subclass of: glycerophospholipid
has_exact_synonym: sn-glycero-3-phosphonocholine

anxiogenic
type: Class
subclass of: psychotropic drug
definition: Any psychotropic drug that induces anxiety or panic.
has_related_synonym: Wikipedia:Anxiogenic
has_related_synonym: panicogenic

Hedgehog signaling pathway inhibitor
type: Class
subclass of: pathway inhibitor
definition: Any pathway inhibitor that inhibits the Hedgehog signalling pathway.
has_related_synonym: Hedgehog pathway inhibitor
has_related_synonym: Hedgehog pathway inhibitors
has_related_synonym: Hedgehog signaling pathway inhibitors
id: CHEBI:140921

1,2-dichloropropane
type: Class
subclass of: organic molecular entity
definition: A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.
formula: C3H6Cl2
smiles: CC(CCl)Cl

4-hydroxynonenal
type: Class
subclass of: TXPO_0004328
definition: A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.

tigecycline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
definition: Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms.
database_cross_reference: CAS:220620-09-7
database_cross_reference: DrugBank:DB00560
database_cross_reference: Drug_Central:2661
database_cross_reference: PMID:17194827
database_cross_reference: PMID:17210772
database_cross_reference: PMID:17220399
database_cross_reference: PMID:17307973
database_cross_reference: PMID:17353238
database_cross_reference: PMID:17353249
database_cross_reference: Reaxys:8379453
has_exact_synonym: (4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
has_related_synonym: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
id: CHEBI:149836

ChemIDplus
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: CAS:220620-09-7

DrugCentral
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: Drug_Central:2661

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17194827

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17210772

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17220399

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17307973

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17353238

ChEMBL
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: PMID:17353249

Reaxys
type: Axiom
annotated source: tigecycline
annotated property: database_cross_reference
annotated target: Reaxys:8379453

acetaldehyde
type: Class
subclass of: aldehyde
definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
database_cross_reference: Wikipedia:Acetaldehyde

ATP
type: Class
subclass of: nucleotide
subclass of: Restriction
  on property: has role
  some values from: neurotransmitter
definition: An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
database_cross_reference: CAS:56-65-5
database_cross_reference: DrugBank:DB00171
has_exact_synonym: adenosine 5'-triphosphate
has_exact_synonym: adenosine triphosphate

NAD(+)
type: Class
subclass of: NAD
definition: The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD(+) is involved in redox reactions, carrying electrons from one reaction to another.

polynucleotide
type: Class
subclass of: biomacromolecule
definition: A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.

GTP
type: Class
subclass of: nucleotide
database_cross_reference: CAS:86-01-1
database_cross_reference: DrugBank:DB04137
has_exact_synonym: guanosine 5'-triphosphate

phosphatidylethanolamine
type: Class
subclass of: glycerophosphoethanolamine
definition: A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine.
database_cross_reference: DrugBank:DB04327
has_exact_synonym: PtdEtn

cholesterol
type: Class
subclass of: steroid
definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3β-hydroxy group.
formula: C27H46O
database_cross_reference: Wikipedia:cholesterol

1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
type: Class
subclass of: phosphatidylinositol bisphosphate
database_cross_reference: IMR:0001353
database_cross_reference: ISBN:0815340729
has_exact_synonym: 1-O-(3-sn-phosphatidyl)-1D-myo-inositol 3,4-bis(dihydrogen phosphate)
has_exact_synonym: 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
has_related_synonym: PtsIns(3,4)P2
has_related_synonym: PtsIns-3,4-P2

Axiom
annotated source: 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
annotated property: database_cross_reference
annotated target: ISBN:0815340729
database_cross_reference: ISBN:0815340729

ethanol
type: Class
subclass of: alcohol
definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
formula: C2H6O
smiles: CCO

phospholipid
type: Class
subclass of: lipid
definition: A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.
has_exact_synonym: C5H6O8PR3

lithocholic acid
type: Class
subclass of: TXPO_0000509
definition: A monohydroxy-5β-cholanic acid with aα-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
formula: C24H40O3

adenosine
type: Class
subclass of: nucleoside
subclass of: Restriction
  on property: has role
  some values from: neurotransmitter
definition: A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond.
database_cross_reference: A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
database_cross_reference: DrugBank:DB00640
has_exact_synonym: Adenine riboside
has_exact_synonym: Adenosine
has_exact_synonym: Ribofuranosyladenine

Axiom
annotated source: adenosine
annotated property: database_cross_reference
annotated target: A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
database_cross_reference: MeSH:D000241

phosphatidic acid
type: Class
subclass of: glycerophospholipid
definition: A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.

cholic acid
type: Class
subclass of: TXPO_0000509
definition: A bile acid that is 5β-cholan-24-oic acid bearing threeα-hydroxy substituents at position 3, 7 and 12.
database_cross_reference: InChIKey:BHQCQFFYRZLCQQ-OELDTZBJSA-N

sphingosine
type: Class
subclass of: sphingolipid
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
definition: A sphing-4-enine in which the double bond is trans.
database_cross_reference: IMR:0100178
has_exact_synonym: Sphingenine
has_exact_synonym: Sphingoid

liposaccharide
type: Class
subclass of: lipid
subclass of: polysaccharide
definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
has_exact_synonym: LPS
comment: Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants.

Axiom
annotated source: liposaccharide
annotated property: comment
annotated target: Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants.
database_cross_reference: ISBN:0815340729

17β-Estradiol
type: Class
subclass of: estradiol
definition: The 17beta-isomer of estradiol.

NADPH
type: Class
subclass of: nucleotide
definition: NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
database_cross_reference: CHEBI:16474
database_cross_reference: Wikipedia:NADPH
has_exact_synonym: 2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
has_related_synonym: NADP-reduced

nitric oxide
type: Class
subclass of: radical
definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.

trichloroethylene
type: Class
subclass of: organic molecular entity
definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
formula: C2HCl3
smiles: ClC=C(Cl)Cl
database_cross_reference: CAS:79-01-6
database_cross_reference: Wikipedia:Trichloroethylene
has_exact_synonym: 1,1,2-trichloroethene

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
type: Class
subclass of: phosphatidylinositol trisphosphate
database_cross_reference: IMR:0001352
has_exact_synonym: 1-O-(3-sn-phosphatidyl)-1D-myo-inositol 3,4,5-tris(dihydrogen phosphate)
has_exact_synonym: 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
has_exact_synonym: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
has_exact_synonym: Phosphatidylinositol-3,4,5-trisphosphate
has_related_synonym: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
has_related_synonym: PIP3
has_related_synonym: PtsIns(3,4,5)P3

carbohydrate
type: Class
subclass of: organic molecular entity
definition: Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.

albendazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anthelminthic drug
subclass of: Restriction
  on property: has role
  some values from: tubulin modulator
subclass of: Restriction
  on property: has role
  some values from: microtubule-destabilising agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.
database_cross_reference: Beilstein:752696
database_cross_reference: CAS:54965-21-8
database_cross_reference: DrugBank:DB00518
database_cross_reference: Drug_Central:103
database_cross_reference: LINCS:LSM-3782
database_cross_reference: PMID:22152396
database_cross_reference: PMID:24403707
database_cross_reference: PMID:24411094
database_cross_reference: Pesticides:albendazole
database_cross_reference: Reaxys:752696
has_exact_synonym: Albendazole
has_exact_synonym: albendazole
has_exact_synonym: methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate
has_related_synonym: (5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
has_related_synonym: 5-(propylthio)-2-carbomethoxyaminobenzimidazole
has_related_synonym: Albenza
has_related_synonym: Eskazole
has_related_synonym: O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate
has_related_synonym: Proftril
has_related_synonym: Valbazen
has_related_synonym: Zentel
id: CHEBI:16664

Beilstein
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: Beilstein:752696

ChemIDplus
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: CAS:54965-21-8

DrugCentral
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: Drug_Central:103

Europe PMC
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: PMID:22152396

Europe PMC
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: PMID:24403707

Europe PMC
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: PMID:24411094

Alan Wood's Pesticides
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: Pesticides:albendazole

Reaxys
type: Axiom
annotated source: albendazole
annotated property: database_cross_reference
annotated target: Reaxys:752696

peptide
type: Class
subclass of: molecular entity
definition: Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
imported from: chebi.owl

1-phosphatidyl-1D-myo-inositol
type: Class
subclass of: phosphatidylinositol
definition: A phosphatidylinositol in which the inositol moiety is the 1D-myo isomer and the phosphatidyl group is located at its position 1.
formula: C11H17O13P
database_cross_reference: PMID:28600633
has_exact_synonym: 1-O-(3-sn-phosphatidyl)-1D-myo-inositol

guanosine
type: Class
subclass of: nucleoside
definition: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.

chenodeoxycholic acid
type: Class
subclass of: organic molecular entity
subclass of: TXPO_0000509
subclass of: Restriction
  on property: has role
  some values from: mouse metabolite
subclass of: Restriction
  on property: has role
  some values from: human metabolite
definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
definition: A dihydroxy-5β-cholanic acid that is (5β)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
description: InChIKey:RUDATBOHQWOJDD-BSWAIDMHSA-N
database_cross_reference: Beilstein:3219887
database_cross_reference: CAS:474-25-9
database_cross_reference: DrugBank:DB06777
database_cross_reference: Drug_Central:4361
database_cross_reference: LINCS:LSM-5353
database_cross_reference: LIPID_MAPS_instance:LMST04010032
database_cross_reference: PMID:11530998
database_cross_reference: PMID:16037564
database_cross_reference: PMID:24448653
database_cross_reference: PMID:24464484
database_cross_reference: Reaxys:3219887
has_exact_synonym: 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
has_exact_synonym: Chenodeoxycholic acid
has_related_synonym: 3alpha,7alpha-Dihydroxy-5beta-cholanic acid
has_related_synonym: 7alpha-hydroxylithocholic acid
has_related_synonym: CDCA
has_related_synonym: Chenix
has_related_synonym: Chenodiol
has_related_synonym: anthropodeoxycholic acid
has_related_synonym: anthropodesoxycholic acid
has_related_synonym: chenic acid
has_related_synonym: gallodesoxycholic acid
id: CHEBI:16755

Beilstein
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: Beilstein:3219887

ChemIDplus
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: CAS:474-25-9

DrugCentral
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: Drug_Central:4361

LIPID MAPS
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMST04010032

Europe PMC
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: PMID:11530998

Europe PMC
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: PMID:16037564

Europe PMC
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: PMID:24448653

Europe PMC
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: PMID:24464484

Reaxys
type: Axiom
annotated source: chenodeoxycholic acid
annotated property: database_cross_reference
annotated target: Reaxys:3219887

AMP
type: Class
subclass of: nucleotide
definition: A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
database_cross_reference: A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
database_cross_reference: CAS:20398-34-9
has_exact_synonym: Adenosine 5'-monophosphate

L-gamma-glutamyl-L-cysteinylglycine
type: Class
subclass of: peptide
definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
formula: C10H17N3O6S
database_cross_reference: DrugBank:DB00143
database_cross_reference: Wikipedia:Glutathione
has_exact_synonym: Glutathione
has_related_synonym: 5-L-Glutamyl-L-cysteinylglycine
has_related_synonym: GSH
has_related_synonym: Reduced glutathione

NADH
type: Class
subclass of: NAD
definition: A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.
database_cross_reference: DrugBank:DB00157
database_cross_reference: Wikipedia:Nicotinamide_adenine_dinucleotide

salicylic acid
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antifungal agent
definition: A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.
formula: C7H6O3
smiles: OC(=O)c1ccccc1O
database_cross_reference: CAS:69-72-7
database_cross_reference: DrugBank:DB00936
database_cross_reference: Wikipedia:Salicylic_acid
has_exact_synonym: 2-hydroxybenzoic acid

monoacylglycerol phosphate
type: Class
subclass of: glycerophospholipid
definition: Derivatives of phosphoglycerols which have only one of the alcohol groups of the glycerol backbone ester-linked with a fatty acid.
has_exact_synonym: lysophospholipids
has_exact_synonym: monoacylglycerol phosphates
has_exact_synonym: monoacylglycerophosphate
has_exact_synonym: monoacylglycerophosphates
has_related_synonym: Lysophospholipid

bilirubin
type: Class
subclass of: organic molecular entity
definition: A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
formula: C33H36N4O6
database_cross_reference: Wikipedia:Bilirubin

deoxyribonucleic acid
type: Class
subclass of: nucleic acid
definition: High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.
imported from: chebi.owl
has_related_synonym: DNA

glucose
type: Class
subclass of: monosaccharide
definition: An aldohexose used as a source of energy and metabolic intermediate.
imported from: chebi.owl

estrone
type: Class
subclass of: steroid
definition: An estrogen that has formula C18H22O2.
database_cross_reference: ATC:G03CA07
database_cross_reference: ATC:G03CC04
database_cross_reference: CASRN:53-16-7
database_cross_reference: DrugBank:DB00655
database_cross_reference: InChIKey:DNXHEGUUPJUMQT-CBZIJGRNSA-N

myo-inositol
type: Class
subclass of: inositol
definition: An inositol having myo- configuration.
database_cross_reference: Wikipedia:Inositol

testosterone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: androgen
subclass of: Restriction
  on property: has role
  some values from: mouse metabolite
subclass of: Restriction
  on property: has role
  some values from: human metabolite
subclass of: Restriction
  on property: has role
  some values from: Daphnia magna metabolite
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
database_cross_reference: Beilstein:1915399
database_cross_reference: Beilstein:3653705
database_cross_reference: CAS:58-22-0
database_cross_reference: DrugBank:DB00624
database_cross_reference: Drug_Central:2607
database_cross_reference: Gmelin:538843
database_cross_reference: LIPID_MAPS_instance:LMST02020002
database_cross_reference: PMID:10438974
database_cross_reference: PMID:11786693
database_cross_reference: PMID:18900503
database_cross_reference: PMID:24498482
database_cross_reference: Reaxys:1915399
has_exact_synonym: 17beta-hydroxyandrost-4-en-3-one
has_exact_synonym: TESTOSTERONE
has_exact_synonym: Testosterone
has_exact_synonym: testosterone
has_related_synonym: 17beta-Hydroxy-4-androsten-3-one
has_related_synonym: 17beta-hydroxy-4-androsten-3-one
has_related_synonym: 4-androsten-17beta-ol-3-one
has_related_synonym: Androderm
has_related_synonym: Testosteron
has_related_synonym: testosterona
has_related_synonym: testosterone
has_related_synonym: testosteronum
id: CHEBI:17347

Beilstein
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: Beilstein:1915399

Beilstein
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: Beilstein:3653705

ChemIDplus
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: CAS:58-22-0

NIST Chemistry WebBook
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: CAS:58-22-0

DrugCentral
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: Drug_Central:2607

Gmelin
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: Gmelin:538843

LIPID MAPS
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMST02020002

Europe PMC
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: PMID:10438974

Europe PMC
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: PMID:11786693

Europe PMC
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: PMID:18900503

Europe PMC
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: PMID:24498482

Reaxys
type: Axiom
annotated source: testosterone
annotated property: database_cross_reference
annotated target: Reaxys:1915399

2-acetamidofluorene
type: Class
subclass of: organic molecular entity
definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
formula: C15H13NO
smiles: C(=O)(NC=1C=C2C(C=3C(C2)=CC=CC3)=CC1)C
database_cross_reference: CAS:53-96-3
database_cross_reference: Wikipedia:2-Acetylaminofluorene
has_exact_synonym: N-(9H-fluoren-2-yl)acetamide
has_related_synonym: 2-AAF
has_related_synonym: 2-Acetylaminofluorene

CMP
type: Class
subclass of: TXPO_0002623
definition: A cytidine 5'-phosphate that has formula C9H14N3O8P.

aldehyde
type: Class
subclass of: organic molecular entity
definition: A compound RC(2O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.

phosphatidylglycerol
type: Class
subclass of: glycerophosphoglycerols
definition: A glycerophosphoglycerol that is glycerol in which the hydrogen of one of the primary hydroxy groups has been replaced by a phosphatidyl group.

gemcitabine
type: Class
subclass of: organic molecular entity
definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
database_cross_reference: Beilstein:5382060
database_cross_reference: CAS:95058-81-4
database_cross_reference: DrugBank:DB00441
database_cross_reference: Drug_Central:1283
database_cross_reference: LINCS:LSM-5333
database_cross_reference: PMID:11034044
database_cross_reference: PMID:11061612
database_cross_reference: PMID:11088063
database_cross_reference: PMID:11122828
database_cross_reference: PMID:11132538
database_cross_reference: PMID:11142482
database_cross_reference: PMID:11221019
database_cross_reference: PMID:11356111
database_cross_reference: PMID:11374818
database_cross_reference: PMID:11489002
database_cross_reference: PMID:11504793
database_cross_reference: PMID:11510027
database_cross_reference: PMID:11585734
database_cross_reference: PMID:11595724
database_cross_reference: PMID:11807603
database_cross_reference: PMID:11859947
database_cross_reference: PMID:11901308
database_cross_reference: PMID:12057041
database_cross_reference: PMID:12057046
database_cross_reference: PMID:12057157
database_cross_reference: PMID:12115355
database_cross_reference: PMID:12142097
database_cross_reference: PMID:12520460
database_cross_reference: PMID:12571808
database_cross_reference: PMID:12722678
database_cross_reference: PMID:12722691
database_cross_reference: PMID:12743987
database_cross_reference: PMID:12761494
database_cross_reference: PMID:12798170
database_cross_reference: PMID:12917815
database_cross_reference: PMID:12954073
database_cross_reference: PMID:14606642
database_cross_reference: PMID:14653877
database_cross_reference: PMID:14720338
database_cross_reference: PMID:15131028
database_cross_reference: PMID:15160243
database_cross_reference: PMID:15221904
database_cross_reference: PMID:15282439
database_cross_reference: PMID:15297392
database_cross_reference: PMID:15542781
database_cross_reference: PMID:15637766
database_cross_reference: PMID:15744590
database_cross_reference: PMID:16001951
database_cross_reference: PMID:16041610
database_cross_reference: PMID:16080557
database_cross_reference: PMID:16143373
database_cross_reference: PMID:16149285
database_cross_reference: PMID:16317298
database_cross_reference: PMID:16500746
database_cross_reference: PMID:16555971
database_cross_reference: PMID:16584929
database_cross_reference: PMID:16807461
database_cross_reference: PMID:16807463
database_cross_reference: PMID:16894289
database_cross_reference: PMID:16905983
database_cross_reference: PMID:17101674
database_cross_reference: PMID:17296311
database_cross_reference: PMID:17296587
database_cross_reference: PMID:17347561
database_cross_reference: PMID:17429628
database_cross_reference: PMID:17460420
database_cross_reference: PMID:17602464
database_cross_reference: PMID:17639396
database_cross_reference: PMID:17887663
database_cross_reference: PMID:17939651
database_cross_reference: PMID:17941128
database_cross_reference: PMID:17987263
database_cross_reference: PMID:18035967
database_cross_reference: PMID:18050344
database_cross_reference: PMID:18086345
database_cross_reference: PMID:18166944
database_cross_reference: PMID:18186604

Beilstein
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: Beilstein:5382060

ChemIDplus
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: CAS:95058-81-4

DrugBank
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: CAS:95058-81-4

DrugCentral
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: Drug_Central:1283

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11034044

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11061612

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11088063

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11122828

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11132538

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11142482

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11221019

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11356111

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11374818

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11489002

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11504793

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11510027

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11585734

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11595724

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11807603

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11859947

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:11901308

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12057041

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12057046

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12057157

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12115355

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12142097

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12520460

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12571808

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12722678

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12722691

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12743987

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12761494

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12798170

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12917815

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:12954073

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:14606642

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:14653877

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:14720338

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15131028

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15160243

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15221904

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15282439

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15297392

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15542781

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15637766

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:15744590

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16001951

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16041610

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16080557

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16143373

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16149285

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16317298

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16500746

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16555971

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16584929

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16807461

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16807463

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16894289

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:16905983

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17101674

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17296311

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17296587

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17347561

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17429628

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17460420

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17602464

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17639396

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17887663

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17939651

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17941128

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:17987263

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18035967

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18050344

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18086345

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18166944

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18186604

ChEMBL
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18257544

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18348652

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18773046

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18789834

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18819792

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:18981552

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:19034448

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:19177022

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:19399788

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:19839926

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:19879060

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:22763439

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:28594276

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:28608357

Europe PMC
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: PMID:28912244

Reaxys
type: Axiom
annotated source: gemcitabine
annotated property: database_cross_reference
annotated target: Reaxys:5382060

CTP
type: Class
subclass of: TXPO_0002623
has_exact_synonym: cytidine 5'-(tetrahydrogen triphosphate)

Axiom
annotated source: CTP
annotated property: has_exact_synonym
annotated target: cytidine 5'-(tetrahydrogen triphosphate)
database_cross_reference: IUPAC

bis(2-ethylhexyl) phthalate
type: Class
subclass of: organic molecular entity
definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
formula: C24H38O4
database_cross_reference: CAS:117-81-7
has_exact_synonym: DEHP
has_exact_synonym: Diethylhexylphthalate

ceramide
type: Class
subclass of: sphingolipid
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
definition: Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.
database_cross_reference: IMR:0100177
has_exact_synonym: Cer
has_exact_synonym: N-acylated sphingoid

gentamicin
type: Class
subclass of: organic molecular entity
definition: Gentamicin is a parenterally administered, broad spectrum aminoglycoside antibiotic typically used for moderate to severe gram negative infections. Despite its wide use, gentamicin has not been definitively linked to instances of clinically apparent liver injury.
database_cross_reference: CAS:1403-66-3
database_cross_reference: DrugBank:DB00798
database_cross_reference: MeSH:D005839
database_cross_reference: Open TG-Gates compound_id=00147
database_cross_reference: https://livertox.nlm.nih.gov//Gentamicin.htm
database_cross_reference: https://pubchem.ncbi.nlm.nih.gov/compound/3467

triglyceride
type: Class
subclass of: organic molecular entity
definition: Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.
formula: C6H5O6R3
smiles: [*]C(=O)OCC(COC([*])=O)OC([*])=O
database_cross_reference: PMID:2474544
has_exact_synonym: Triacylglycerol

Glutathione disulfide
type: Class
subclass of: molecular entity
formula: C20H32N6O12S2
database_cross_reference: CAS:27025-41-8
database_cross_reference: DrugBank:DB03310
has_exact_synonym: GSSG
has_exact_synonym: Oxidized glutathione
has_exact_synonym: Oxiglutatione

styrene oxide
type: Class
subclass of: organic molecular entity
definition: An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.
formula: C8H8O
smiles: C1OC1c1ccccc1
database_cross_reference: CAS:96-09-3
database_cross_reference: Wikipedia:Styrene_oxide
has_exact_synonym: 2-phenyloxirane
has_related_synonym: styrene-7,8-oxide

N-hydroxy-2-acetamidofluorene
type: Class
subclass of: organic molecular entity
formula: C15H13NO2
smiles: CC(=O)N(O)c1ccc-2c(Cc3ccccc-23)c1
database_cross_reference: CAS:53-95-2
has_exact_synonym: N-(9H-fluoren-2-yl)-N-hydroxyacetamide
has_exact_synonym: N-OH-AAF
has_exact_synonym: N-hydroxy-2-acetylaminofluorene

acyl-CoA
type: Class
subclass of: organic molecule
definition: A thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.
formula: C22H35N7O17P3SR
database_cross_reference: CAS:9029-97-4
database_cross_reference: PMID:11264983
database_cross_reference: PMID:11524729
has_exact_synonym: Acyl coenzyme A
has_exact_synonym: Acyl-CoA

lipid
type: Class
subclass of: organic molecular entity
definition: 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
comment: Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent.

Axiom
annotated source: lipid
annotated property: comment
annotated target: Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent.
database_cross_reference: ISBN:0815340729

polysaccharide
type: Class
subclass of: carbohydrate
subclass of: biomacromolecule
definition: A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
has_exact_synonym: Polysaccharide
has_exact_synonym: polysaccharides

phosphoinositide
type: Class
subclass of: phosphatidylinositol
definition: Any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol.

iron atom
type: Class
subclass of: atom
definition: An iron group element atom that has atomic number 26.
formula: Fe
smiles: [Fe]
database_cross_reference: CAS:7439-89-6
database_cross_reference: DrugBank:DB01592
has_exact_synonym: iron

phosphatidyl-L-serine
type: Class
subclass of: glycerophosphoserine
definition: A class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.
database_cross_reference: DrugBank:DB00144
has_exact_synonym: Ptd-L-Ser
has_exact_synonym: phosphatidylserine

1,4-dithiothreitol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: chelator
definition: The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.
database_cross_reference: CAS:3483-12-3
database_cross_reference: DrugBank:DB04447
database_cross_reference: LINCS:LSM-36870

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
type: Class
subclass of: phosphatidylinositol bisphosphate
has_alternative_id: IMR:0200477
database_cross_reference: IMR:0001350
has_exact_synonym: PI(4,5)P2
has_exact_synonym: PIP2
has_exact_synonym: Phosphatidylinositol-4,5-bisphosphate
has_exact_synonym: PtsIns-4,5-P2
comment: PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol.

Axiom
annotated source: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
annotated property: comment
annotated target: PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol.
database_cross_reference: ISBN:0815340729

superoxide
type: Class
subclass of: TXPO_0000201
formula: O2
smiles: [O][O-]
has_exact_synonym: dioxidanidyl

ATP synthase inhibitor (mitochondrial respiratory-chain inhibitor)
type: Class
subclass of: mitochondrial respiratory-chain inhibitor
definition: A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase.

aflatoxin
type: Class
subclass of: organic molecular entity
definition: Any of a group of related and highly toxic secondary metabolites (mycotoxins) whose main structural feature is a fused coumarin-bis(dihydrofuran) ring system and which are produced by strains of the moulds Aspergillus flavus or A. parasiticus, together with further metabolites of these mycotoxins.

alkali metal atom
type: Class
subclass of: metal atom

alkylating agent
type: Class
subclass of: mutagen
subclass of: TXPO_0001316
definition: Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
id: CHEBI:22333

anion
type: Class
subclass of: ion
definition: A monoatomic or polyatomic species having one or more elementary charges of the electron.

antioxidant
type: Class
subclass of: chemical role
definition: A role that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
definition: A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
has_related_synonym: antioxidants
has_related_synonym: antioxydant
has_related_synonym: antoxidant
id: CHEBI:22586

antiviral agent
type: Class
subclass of: antimicrobial agent
definition: A substance that destroys or inhibits replication of viruses.
has_related_synonym: anti-viral agent
has_related_synonym: anti-viral agents
has_related_synonym: antiviral
has_related_synonym: antiviral agents
has_related_synonym: antivirals
id: CHEBI:22587

barbiturates
type: Class
subclass of: organic molecular entity
definition: Members of the class of pyrimidones consisting of pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) and its derivatives. Largest group of the synthetic sedative/hypnotics, sharing a characteristic six-membered ring structure.

base
type: Class
subclass of: chemical role
has_related_synonym: A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).

calcium atom
type: Class
subclass of: atom
database_cross_reference: CAS:7440-70-2
database_cross_reference: DrugBank:DB01373
has_exact_synonym: calcium
has_related_synonym: Ca

EC 4.2.1.1 (carbonic anhydrase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule.
has_related_synonym: EC 4.2.1.1 (carbonic anhydrase) inhibitors
has_related_synonym: EC 4.2.1.1 inhibitor
has_related_synonym: EC 4.2.1.1 inhibitors
has_related_synonym: anhydrase inhibitor
has_related_synonym: anhydrase inhibitors
has_related_synonym: carbonate anhydrase inhibitor
has_related_synonym: carbonate anhydrase inhibitors
has_related_synonym: carbonate dehydratase inhibitor
has_related_synonym: carbonate dehydratase inhibitors
has_related_synonym: carbonate hydro-lyase (carbon-dioxide-forming) inhibitor
has_related_synonym: carbonate hydro-lyase (carbon-dioxide-forming) inhibitors
has_related_synonym: carbonate hydro-lyase inhibitor
has_related_synonym: carbonate hydro-lyase inhibitors
has_related_synonym: carbonic acid anhydrase inhibitor
has_related_synonym: carbonic acid anhydrase inhibitors
has_related_synonym: carbonic anhydrase (EC 4.2.1.1) inhibitor
has_related_synonym: carbonic anhydrase (EC 4.2.1.1) inhibitors
has_related_synonym: carbonic anhydrase A inhibitor
has_related_synonym: carbonic anhydrase A inhibitors
has_related_synonym: carbonic anhydrase inhibitor
has_related_synonym: carbonic anhydrase inhibitors
has_related_synonym: carboxyanhydrase inhibitor
has_related_synonym: carboxyanhydrase inhibitors
id: CHEBI:23018

chemosterilant
type: Class
subclass of: pesticide
definition: A substance intended to sterilize any organism.
has_related_synonym: chemosterilants
id: CHEBI:23092

coenzyme
type: Class
subclass of: cofactor
definition: A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.

cofactor
type: Class
subclass of: TXPO_0003732
definition: An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
database_cross_reference: Wikipedia:Cofactor_(biochemistry)

molecular entity
type: Class
subclass of: chemical entity
definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.

4-(phenylazo)aniline
type: Class
subclass of: organic molecular entity
formula: C12H11N3
smiles: C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N
database_cross_reference: CAS:60-09-3
database_cross_reference: Wikipedia:Aniline_Yellow
has_exact_synonym: 4-Aminoazobenzene
has_exact_synonym: 4-[(E)-phenyldiazenyl]aniline
has_exact_synonym: 4-phenyldiazenylaniline
has_exact_synonym: AAB

acarbose
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: hypoglycemic agent
subclass of: Restriction
  on property: has role
  some values from: EC 3.2.1.1 (alpha-amylase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 3.2.1.20 (alpha-glucosidase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.
database_cross_reference: CAS:56180-94-0
database_cross_reference: DrugBank:DB00284
database_cross_reference: Drug_Central:39
database_cross_reference: LINCS:LSM-4345
database_cross_reference: PMID:11937512
database_cross_reference: PMID:18248270
database_cross_reference: PMID:25044702
database_cross_reference: PMID:8893066
database_cross_reference: PMID:9805641
has_exact_synonym: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
has_exact_synonym: Acarbose
has_related_synonym: Glucobay
has_related_synonym: Precose
has_related_synonym: acarbosa
has_related_synonym: acarbose
has_related_synonym: acarbosum
id: CHEBI:2376

ChemIDplus
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: CAS:56180-94-0

DrugCentral
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: Drug_Central:39

Europe PMC
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: PMID:11937512

Europe PMC
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: PMID:18248270

Europe PMC
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: PMID:25044702

Europe PMC
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: PMID:8893066

Europe PMC
type: Axiom
annotated source: acarbose
annotated property: database_cross_reference
annotated target: PMID:9805641

drug
type: Class
subclass of: pharmacological role
subclass of: pharmaceutical
definition: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
definition: Intended use of the molecular entity or part thereof by humans.
has_related_synonym: drugs
has_related_synonym: medicine
id: CHEBI:23888

icosanoid
type: Class
subclass of: fatty acid derivative
definition: Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).
database_cross_reference: IMR:0001381
has_exact_synonym: eicosanoid

enzyme inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
subclass of: TXPO_0003711
definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
has_exact_synonym: enzyme inhibitor
has_related_synonym: enzyme inhibitors
has_related_synonym: inhibidor enzimatico
has_related_synonym: inhibidores enzimaticos
has_related_synonym: inhibiteur enzymatique
has_related_synonym: inhibiteurs enzymatiques
id: CHEBI:23924

estradiol
type: Class
subclass of: steroid
definition: A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.
description: InChIKey=VOXZDWNPVJITMN-WKUFJEKOSA-N
database_cross_reference: Wikipedia:Estradiol

N-ethyl-N-nitrosourea
type: Class
subclass of: organic molecular entity
definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
formula: C3H7N3O2
smiles: CCN(N=O)C(N)=O
database_cross_reference: CAS:759-73-9
database_cross_reference: Wikipedia:ENU
has_exact_synonym: 1-ethyl-1-nitrosourea

bromfenac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure.
database_cross_reference: Beilstein:8335547
database_cross_reference: CAS:91714-94-2
database_cross_reference: DrugBank:DB00963
database_cross_reference: Drug_Central:401
database_cross_reference: LINCS:LSM-5585
has_exact_synonym: [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
has_related_synonym: 2-amino-3-(4-bromobenzoyl)benzeneacetic acid
has_related_synonym: [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
has_related_synonym: bromfenac
has_related_synonym: bromfenaco
has_related_synonym: bromfenacum
id: CHEBI:240107

Beilstein
type: Axiom
annotated source: bromfenac
annotated property: database_cross_reference
annotated target: Beilstein:8335547

ChemIDplus
type: Axiom
annotated source: bromfenac
annotated property: database_cross_reference
annotated target: CAS:91714-94-2

DrugCentral
type: Axiom
annotated source: bromfenac
annotated property: database_cross_reference
annotated target: Drug_Central:401

fungicide
type: Class
subclass of: pesticide
subclass of: antifungal agent
definition: A substance used to destroy fungal pests.
has_related_synonym: fungicides
id: CHEBI:24127

gamma-glutamylcysteine
type: Class
subclass of: molecular entity
has_exact_synonym: gamma-GC

glycerophosphoglycerols
type: Class
subclass of: glycerophospholipid

chemical entity
type: Class
subclass of: object
definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
database_cross_reference: http://purl.obolibrary.org/obo/IMR_0000947
has_exact_synonym: chemical compound

biological role
type: Class
subclass of: role
definition: A role played by the molecular entity or part thereof within a biological context.
has_related_synonym: biological function
id: CHEBI:24432

hormone
type: Class
subclass of: molecular messenger
subclass of: agonist
definition: Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
database_cross_reference: GO:0005180
has_related_synonym: endocrine
has_related_synonym: hormones
id: CHEBI:24621
comment: substance with hormone role: http://purl.bioontology.org/ontology/STY/T125

proton
type: Class
subclass of: molecular entity
definition: Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.
imported from: chebi.owl

imine
type: Class
subclass of: organic molecular entity
definition: Compounds having the structure RN=CR2 (R = H, hydrocarbyl). Thus analogues of aldehydes or ketones, having NR doubly bonded to carbon; aldimines have the structure RCH=NR, ketimines have the structure R'2C=NR (where R' is not H). Imines include azomethines and Schiff bases. Imine is used as a suffix in systematic nomenclature to denote the C=NH group excluding the carbon atom.
database_cross_reference: CHEBI:24783
database_cross_reference: http://jglobal.jst.go.jp/en/detail
database_cross_reference: http://purl.jp/bio/4/id/200906016906308703

inositol
type: Class
subclass of: lipid

insecticide
type: Class
subclass of: pesticide
definition: Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.
has_related_synonym: insecticides
id: CHEBI:24852

ion
type: Class
subclass of: molecular entity
definition: A molecular entity having a net electric charge.

aflatoxin B1
type: Class
subclass of: aflatoxin
definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
formula: C17H12O6
database_cross_reference: CAS:1162-65-8
has_exact_synonym: (6aR,9aS)-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione

metabolite
type: Class
subclass of: biochemical role
definition: Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
has_exact_synonym: metabolite
has_related_synonym: metabolites
has_related_synonym: primary metabolites
has_related_synonym: secondary metabolites
id: CHEBI:25212

mitochondrial respiratory-chain inhibitor
type: Class
subclass of: respiratory-chain inhibitor
definition: A role played by the entity that inhibits the mitochondrial respiratory-chain.
has_related_synonym: mitochondrial electron transport chain inhibitors

molecule
type: Class
subclass of: molecular entity
definition: Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.

mutagen
type: Class
subclass of: genotoxin
definition: An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
database_cross_reference: Wikipedia:Mutagen
has_related_synonym: mutagene
has_related_synonym: mutagenes
has_related_synonym: mutagenic agent
has_related_synonym: mutageno
has_related_synonym: mutagenos
has_related_synonym: mutagens
id: CHEBI:25435

mycotoxin
type: Class
subclass of: toxin
definition: Poisonous substance produced by fungi.

7,12-dimethyltetraphene
type: Class
subclass of: organic molecular entity
definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
formula: C20H16
smiles: Cc1c2ccccc2c(C)c2c1ccc1ccccc21
database_cross_reference: CAS:57-97-6
has_exact_synonym: 7,12-dimethylbenz(a)anthracene
has_exact_synonym: 7,12-dimethylbenzo[a]anthracene

nematicide
type: Class
subclass of: pesticide
definition: A substance used to destroy pests of the phylum Nematoda (roundworms).
has_related_synonym: nematicides
has_related_synonym: nematocide
has_related_synonym: nematocides
id: CHEBI:25491

neurotransmitter
type: Class
subclass of: molecular messenger
definition: An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
database_cross_reference: IMR:0000967 (obsolete)

nitrogen atom
type: Class
subclass of: atom
has_exact_synonym: N

organophosphorus compound
type: Class
subclass of: organic molecular entity
definition: An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.

oxygen atom
type: Class
subclass of: atom
database_cross_reference: Inchikey:QVGXLLKOCUKJST-UHFFFAOYSA-N
has_exact_synonym: oxygen

oxygen molecular entity
type: Class
subclass of: molecular entity

hydroperoxyl
type: Class
subclass of: TXPO_0000201
formula: HO2
smiles: [H]O[O]
has_related_synonym: (HO2)(.)

pesticide
type: Class
subclass of: role
definition: Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.
has_exact_synonym: pesticide
has_related_synonym: Pestizid
has_related_synonym: Pestizide
has_related_synonym: pesticides
id: CHEBI:25944

potassium atom
type: Class
subclass of: alkali metal atom
database_cross_reference: CAS:7440-09-7
database_cross_reference: DrugBank:DB01345
has_exact_synonym: potassium

prostanoid
type: Class
subclass of: icosanoid
definition: The family of natural prostaglandins and prostaglandin-like compounds.

radical
type: Class
subclass of: molecular entity
definition: A molecular entity possessing an unpaired electron.
has_exact_synonym: free radical

reactive oxygen species
type: Class
subclass of: oxygen molecular entity
definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
database_cross_reference: Wikipedia:Reactive_oxygen_species

saturated fatty acid
type: Class
subclass of: lipid
definition: Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess.

amiodarone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has quality
  some values from: PATO_0001884
subclass of: Restriction
  on property: has quality
  some values from: PATO_0001886
subclass of: Restriction
  on property: has role
  some values from: cardiovascular drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
formula: C25H29I2NO3
database_cross_reference: Beilstein:1271711
database_cross_reference: CAS:1951-25-3
database_cross_reference: ChemicalBook:CB5310616
database_cross_reference: DrugBank:DB01118
database_cross_reference: Drug_Central:176
database_cross_reference: LINCS:LSM-2379
database_cross_reference: Open TG-Gates compound_id=00033
database_cross_reference: PMID:10188629
database_cross_reference: PMID:16479044
database_cross_reference: PMID:18368867
has_exact_synonym: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
has_exact_synonym: Amiodarone
has_related_synonym: 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran
has_related_synonym: 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone
has_related_synonym: 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
has_related_synonym: amiodarona
has_related_synonym: amiodaronum
id: CHEBI:2663

Beilstein
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: Beilstein:1271711

ChemIDplus
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: CAS:1951-25-3

Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: ChemicalBook:CB5310616
database_cross_reference: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5310616

DrugCentral
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: Drug_Central:176

Europe PMC
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: PMID:10188629

Europe PMC
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: PMID:16479044

Europe PMC
type: Axiom
annotated source: amiodarone
annotated property: database_cross_reference
annotated target: PMID:18368867

amitriptyline
type: Class
subclass of: organic molecular entity
definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
formula: C20H23N
smiles: CN(C)CCC=C1c2ccccc2CCc2ccccc12
database_cross_reference: CAS:50-48-6
database_cross_reference: DrugBank:DB00321
database_cross_reference: LINCS:LSM-3190
database_cross_reference: MeSH:D000639
database_cross_reference: Patent:WO2011089289
database_cross_reference: Wikipedia:Amitriptyline
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine

sodium atom
type: Class
subclass of: alkali metal atom

sphingolipid
type: Class
subclass of: lipid
definition: Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.

sulfur atom
type: Class
subclass of: atom
database_cross_reference: CAS:7704-34-9
has_exact_synonym: sulfur

thromboxane
type: Class
subclass of: prostanoid
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003686
definition: A class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.
database_cross_reference: IMR:0100020
has_exact_synonym: TX

toxin
type: Class
subclass of: poison
definition: Poisonous substance produced by a biological organism such as a microbe, animal or plant.
database_cross_reference: Wikipedia:Toxin

triol
type: Class
subclass of: organic molecular entity
definition: A chemical compound containing three hydroxy groups.

uric acid
type: Class
subclass of: organic molecular entity
definition: An oxopurine that is the final oxidation product of purine metabolism.

tetrachloromethane
type: Class
subclass of: organic molecular entity
definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
formula: CCl4
smiles: ClC(Cl)(Cl)Cl
database_cross_reference: CAS:56-23-5
database_cross_reference: LINCS:LSM-37019
database_cross_reference: Wikipedia:Carbon_Tetrachloride
has_related_synonym: CCl4
has_related_synonym: Carbon tetrachloride

carbon atom
type: Class
subclass of: atom
database_cross_reference: CAS:7440-44-0
database_cross_reference: Inchikey:OKTJSMMVPCPJKN-UHFFFAOYSA-N
has_exact_synonym: carbon

acetazolamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: EC 4.2.1.1 (carbonic anhydrase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: diuretic
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:212994
database_cross_reference: CAS:59-66-5
database_cross_reference: DrugBank:DB00819
database_cross_reference: Drug_Central:56
database_cross_reference: Gmelin:365421
database_cross_reference: LINCS:LSM-5543
has_exact_synonym: Acetazolamide
has_exact_synonym: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
has_related_synonym: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
has_related_synonym: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
has_related_synonym: 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide
has_related_synonym: Defiltran
has_related_synonym: Diacarb
has_related_synonym: Diamox
has_related_synonym: Diluran
has_related_synonym: Glaupax
has_related_synonym: N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
has_related_synonym: N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
has_related_synonym: acetazolamida
has_related_synonym: acetazolamide
has_related_synonym: acetazolamidum
id: CHEBI:27690

Beilstein
type: Axiom
annotated source: acetazolamide
annotated property: database_cross_reference
annotated target: Beilstein:212994

ChemIDplus
type: Axiom
annotated source: acetazolamide
annotated property: database_cross_reference
annotated target: CAS:59-66-5

NIST Chemistry WebBook
type: Axiom
annotated source: acetazolamide
annotated property: database_cross_reference
annotated target: CAS:59-66-5

DrugCentral
type: Axiom
annotated source: acetazolamide
annotated property: database_cross_reference
annotated target: Drug_Central:56

Gmelin
type: Axiom
annotated source: acetazolamide
annotated property: database_cross_reference
annotated target: Gmelin:365421

griseofulvin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antibacterial agent
subclass of: Restriction
  on property: has role
  some values from: Penicillium metabolite
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.
database_cross_reference: Beilstein:95226
database_cross_reference: CAS:126-07-8
database_cross_reference: DrugBank:DB00400
database_cross_reference: Drug_Central:1331
database_cross_reference: LINCS:LSM-5259
database_cross_reference: LIPID_MAPS_instance:LMPK13060001
database_cross_reference: PMID:14407521
database_cross_reference: PMID:15078340
database_cross_reference: PMID:16922553
database_cross_reference: PMID:23111828
database_cross_reference: PMID:25476923
database_cross_reference: PMID:3277037
database_cross_reference: Reaxys:95226
has_exact_synonym: (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
has_exact_synonym: Griseofulvin
has_related_synonym: (+)-griseofulvin
has_related_synonym: Curling factor
has_related_synonym: Fulcin
has_related_synonym: Fulvicin
has_related_synonym: Grifulvin
has_related_synonym: Grisactin
has_related_synonym: Grisovin
has_related_synonym: Grysio
has_related_synonym: Lamoryl
has_related_synonym: Likuden
has_related_synonym: Poncyl
has_related_synonym: Spirofulvin
has_related_synonym: Sporostatin
has_related_synonym: amudane
has_related_synonym: griseofulvin
has_related_synonym: griseofulvina
has_related_synonym: griseofulvine
has_related_synonym: griseofulvinum
id: CHEBI:27779

Beilstein
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: Beilstein:95226

ChemIDplus
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: CAS:126-07-8

NIST Chemistry WebBook
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: CAS:126-07-8

DrugCentral
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: Drug_Central:1331

LIPID MAPS
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMPK13060001

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:14407521

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:15078340

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:16922553

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:23111828

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:25476923

Europe PMC
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: PMID:3277037

Reaxys
type: Axiom
annotated source: griseofulvin
annotated property: database_cross_reference
annotated target: Reaxys:95226

resveratrol
type: Class
subclass of: TXPO_0000591
subclass of: Restriction
  on property: has role
  some values from: antioxidant
definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
formula: C14H12O3
smiles: [H]C(=C([H])c1cc(O)cc(O)c1)c1ccc(O)cc1
database_cross_reference: CAS:501-36-0
database_cross_reference: DrugBank:DB02709
database_cross_reference: LINCS:LSM-2557
has_exact_synonym: 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

tetracycline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
formula: C22H24N2O8
database_cross_reference: CAS:60-54-8
database_cross_reference: DrugBank:DB00759
database_cross_reference: Wikipedia:Tetracycline
has_exact_synonym: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

rifampicin
type: Class
subclass of: organic molecular entity
definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
database_cross_reference: CASRN:13292-46-1
database_cross_reference: DrugBank:DB01045
database_cross_reference: Wikipedia:Rifampicin

glycogen
type: Class
subclass of: polysaccharide
definition: A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.
database_cross_reference: CAS:9005-79-2

papaverine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: vasodilator agent
subclass of: Restriction
  on property: has role
  some values from: antispasmodic drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
database_cross_reference: CAS:58-74-2
database_cross_reference: DrugBank:DB01113
database_cross_reference: Drug_Central:2056
database_cross_reference: LINCS:LSM-2338
database_cross_reference: PMID:11971205
database_cross_reference: PMID:24414229
database_cross_reference: Reaxys:312930
has_exact_synonym: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
id: CHEBI:28241

ChemIDplus
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: CAS:58-74-2

NIST Chemistry WebBook
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: CAS:58-74-2

DrugCentral
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: Drug_Central:2056

Europe PMC
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: PMID:11971205

Europe PMC
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: PMID:24414229

Reaxys
type: Axiom
annotated source: papaverine
annotated property: database_cross_reference
annotated target: Reaxys:312930

aristolochic acid
type: Class
subclass of: organic molecular entity
definition: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
formula: C17H11NO7
database_cross_reference: CAS:313-67-7
has_exact_synonym: 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid

cardiolipin
type: Class
subclass of: glycerophospholipid
definition: A phosphatidylglycerol composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol.
database_cross_reference: Wikipedia:cardiolipin

chloroethene
type: Class
subclass of: organic molecular entity
definition: A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.
formula: C2H3Cl
smiles: ClC=C
database_cross_reference: CAS:75-01-4
database_cross_reference: Wikipedia:Chloroethene
has_related_synonym: Vinyl chloride
has_related_synonym: クロロエチレン
has_related_synonym: 塩化ビニル

cytarabine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral agent
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: immunosuppressive agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.
database_cross_reference: Beilstein:89175
database_cross_reference: CAS:147-94-4
database_cross_reference: DrugBank:DB00987
database_cross_reference: Drug_Central:770
database_cross_reference: LINCS:LSM-5470
database_cross_reference: PMID:15492802
database_cross_reference: Reaxys:89175
has_exact_synonym: 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
has_exact_synonym: Cytarabine
has_related_synonym: 1-beta-D-Arabinofuranosylcytosine
has_related_synonym: 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
has_related_synonym: Arabinoside C
has_related_synonym: Cytosine arabinoside
has_related_synonym: Cytosine-1-beta-D-arabinofuranoside
has_related_synonym: ara-C
has_related_synonym: arabinocytosine
has_related_synonym: citarabina
has_related_synonym: cytarabine
has_related_synonym: cytarabinum
has_related_synonym: cytosine-beta-D-arabinofuranoside
id: CHEBI:28680

Beilstein
type: Axiom
annotated source: cytarabine
annotated property: database_cross_reference
annotated target: Beilstein:89175

ChemIDplus
type: Axiom
annotated source: cytarabine
annotated property: database_cross_reference
annotated target: CAS:147-94-4

DrugCentral
type: Axiom
annotated source: cytarabine
annotated property: database_cross_reference
annotated target: Drug_Central:770

Europe PMC
type: Axiom
annotated source: cytarabine
annotated property: database_cross_reference
annotated target: PMID:15492802

Reaxys
type: Axiom
annotated source: cytarabine
annotated property: database_cross_reference
annotated target: Reaxys:89175

fructose
type: Class
subclass of: monosaccharide
definition: A ketohexose that is an isomer of glucose.

phosphatidylinositol phosphate
type: Class
subclass of: phosphoinositide
definition: Any member of the phosphoinositide family of compounds, of which seven occur naturally.

coumarin
type: Class
subclass of: organic molecular entity
definition: A chromenone having the keto group located at the 2-position.
smiles: C=1C=CC=C2C1C=CC(=O)O2
database_cross_reference: DrugBank:DB04665
database_cross_reference: PMID:28166217
database_cross_reference: Wikipedia:Coumarin

deoxycholic acid
type: Class
subclass of: TXPO_0000509
definition: A bile acid that is 5β-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
database_cross_reference: InChIKey:KXGVEGMKQFWNSR-LLQZFEROSA-N

phosphatidylinositol
type: Class
subclass of: glycerophosphoinositol
definition: Any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
database_cross_reference: IMR:0001651
has_exact_synonym: PI

1-hydroxyanthraquinone
type: Class
subclass of: organic molecular entity
formula: C14H8O3
smiles: Oc1cccc2C(=O)c3ccccc3C(=O)c12
database_cross_reference: CAS:129-43-1
has_exact_synonym: 1-hydroxyanthracene-9,10-dione

busulfan
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: alkylating agent
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
subclass of: Restriction
  on property: has role
  some values from: teratogenic agent
subclass of: Restriction
  on property: has role
  some values from: insect sterilant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
database_cross_reference: Beilstein:1791786
database_cross_reference: CAS:55-98-1
database_cross_reference: DrugBank:DB01008
database_cross_reference: Drug_Central:438
database_cross_reference: LINCS:LSM-5388
database_cross_reference: PMID:10523796
database_cross_reference: PMID:19361744
database_cross_reference: PMID:19611402
database_cross_reference: Reaxys:1791786
has_exact_synonym: Busulfan
has_exact_synonym: butane-1,4-diyl dimethanesulfonate
has_related_synonym: 1,4-Bis(methanesulfonoxy)butane
has_related_synonym: 1,4-Butanediol dimethanesulfonate
has_related_synonym: 1,4-Dimesyloxybutane
has_related_synonym: 1,4-Dimethanesulfonoxybutane
has_related_synonym: Bisulfex
has_related_synonym: Leucosulfan
has_related_synonym: Mablin
has_related_synonym: Mielucin
has_related_synonym: Misulban
has_related_synonym: Mitostan
has_related_synonym: Myeloleukon
has_related_synonym: Myleran
has_related_synonym: Tetramethylene bis(methanesulfonate)
has_related_synonym: busulfan
has_related_synonym: busulfano
has_related_synonym: busulfanum
id: CHEBI:28901

Beilstein
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: Beilstein:1791786

ChemIDplus
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: CAS:55-98-1

DrugCentral
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: Drug_Central:438

Europe PMC
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: PMID:10523796

Europe PMC
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: PMID:19361744

Europe PMC
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: PMID:19611402

Reaxys
type: Axiom
annotated source: busulfan
annotated property: database_cross_reference
annotated target: Reaxys:1791786

N-acetyl-1,4-benzoquinone imine
type: Class
subclass of: imine
definition: A ketoimine that has formula C8H7NO2.
database_cross_reference: CHEBI:29132
database_cross_reference: http://www.reactome.org/cgi-bin/eventbrowser_st_id
has_exact_synonym: N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide
has_related_synonym: InChI=1S/C8H7NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3
has_related_synonym: NAPQI

Axiom
annotated source: N-acetyl-1,4-benzoquinone imine
annotated property: has_exact_synonym
annotated target: N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide
database_cross_reference: IUPAC NAME

hydroxyl
type: Class
subclass of: TXPO_0000201
formula: HO
smiles: [O][H]

azathioprine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: immunosuppressive agent
subclass of: Restriction
  on property: has role
  some values from: prodrug
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
database_cross_reference: CAS:446-86-6
database_cross_reference: DrugBank:DB00993
database_cross_reference: Drug_Central:269
database_cross_reference: PMID:11064448
database_cross_reference: PMID:15199672
database_cross_reference: PMID:15476481
database_cross_reference: PMID:15628319
database_cross_reference: PMID:15973722
database_cross_reference: PMID:16344342
database_cross_reference: PMID:16397313
database_cross_reference: PMID:16764353
database_cross_reference: PMID:16954801
database_cross_reference: PMID:17381669
database_cross_reference: PMID:17970886
database_cross_reference: PMID:18008354
database_cross_reference: PMID:18336531
database_cross_reference: PMID:19243907
database_cross_reference: PMID:20080917
database_cross_reference: PMID:25248004
database_cross_reference: PMID:25314066
database_cross_reference: PMID:25440430
database_cross_reference: PMID:25443086
database_cross_reference: PMID:25581826
database_cross_reference: PMID:25641386
database_cross_reference: PMID:28166217
database_cross_reference: PMID:8738760
database_cross_reference: PMID:9273463
database_cross_reference: PMID:9345422
database_cross_reference: Reaxys:1225351
has_exact_synonym: 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
has_related_synonym: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
has_related_synonym: 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
has_related_synonym: Imuran (TN)
id: CHEBI:2948

ChemIDplus
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: CAS:446-86-6

DrugCentral
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: Drug_Central:269

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:11064448

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:15199672

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:15476481

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:15628319

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:15973722

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:16344342

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:16397313

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:16764353

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:16954801

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:17381669

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:17970886

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:18008354

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:18336531

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:19243907

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:20080917

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25248004

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25314066

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25440430

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25443086

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25581826

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:25641386

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:28166217

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:8738760

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:9273463

Europe PMC
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: PMID:9345422

Reaxys
type: Axiom
annotated source: azathioprine
annotated property: database_cross_reference
annotated target: Reaxys:1225351

telithromycin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:191114-48-4
database_cross_reference: Drug_Central:2581
has_exact_synonym: TELITHROMYCIN
has_exact_synonym: Telithromycin
has_related_synonym: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside
has_related_synonym: HMR 3647
has_related_synonym: HMR-3647
has_related_synonym: HMR3647
has_related_synonym: RU 66647
has_related_synonym: RU-66647
has_related_synonym: RU66647
id: CHEBI:29688

DrugCentral
type: Axiom
annotated source: telithromycin
annotated property: database_cross_reference
annotated target: Drug_Central:2581

tunicamycin
type: Class
subclass of: organic molecular entity
definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
database_cross_reference: D014415
database_cross_reference: CAS:11089-65-9
database_cross_reference: Open TG-Gates compound_id:00A02
database_cross_reference: Wikipedia:Tunicamycin

benzbromarone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: uricosuric drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
database_cross_reference: Beilstein:273668
database_cross_reference: CAS:3562-84-3
database_cross_reference: Drug_Central:318
database_cross_reference: LINCS:LSM-2239
database_cross_reference: PMID:18636784
database_cross_reference: PMID:26693855
database_cross_reference: PMID:26792818
database_cross_reference: PMID:27391386
database_cross_reference: PMID:28131653
database_cross_reference: PMID:28166217
database_cross_reference: PMID:28202260
database_cross_reference: PMID:7661033
has_exact_synonym: (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone
has_exact_synonym: Benzbromarone
has_related_synonym: 2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran
has_related_synonym: 3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone
has_related_synonym: Uroleap (TN)
id: CHEBI:3023

Beilstein
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: Beilstein:273668

ChemIDplus
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: CAS:3562-84-3

DrugCentral
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: Drug_Central:318

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:18636784

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:26693855

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:26792818

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:27391386

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:28131653

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:28166217

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:28202260

Europe PMC
type: Axiom
annotated source: benzbromarone
annotated property: database_cross_reference
annotated target: PMID:7661033

aflatoxin B1 exo-8,9-epoxide
type: Class
subclass of: aflatoxin
formula: C17H12O7
database_cross_reference: CAS:42583-46-0
has_exact_synonym: 6aS,7aS,8aR,8bR)-4-methoxy-2,3,6a,7a,8a,8b-hexahydrocyclopenta[c]oxireno[4',5']furo[3',2':4,5]furo[2,3-h]chromene-1,10-dione

trichloromethyl(.)
type: Class
subclass of: radical
formula: CCl3
smiles: Cl[C](Cl)Cl

alcohol
type: Class
subclass of: organic molecule
definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
formula: HOR
smiles: O[*]

bicalutamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: androgen antagonist
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
database_cross_reference: Beilstein:5364666
database_cross_reference: CAS:90357-06-5
database_cross_reference: DrugBank:DB01128
database_cross_reference: Drug_Central:367
database_cross_reference: LINCS:LSM-1437
database_cross_reference: PMID:11915584
database_cross_reference: PMID:12015321
database_cross_reference: PMID:12017896
database_cross_reference: PMID:12421104
database_cross_reference: PMID:12959312
database_cross_reference: PMID:15509184
database_cross_reference: PMID:17313204
database_cross_reference: PMID:18062751
database_cross_reference: PMID:19194583
database_cross_reference: PMID:23527766
database_cross_reference: PMID:30784326
database_cross_reference: PMID:31099426
database_cross_reference: Reaxys:5364666
has_exact_synonym: rac-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
has_related_synonym: (+-)-bicalutamide
has_related_synonym: (RS)-4'-cyano-alpha',alpha',alpha',-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide
has_related_synonym: (RS)-bicalutamide
has_related_synonym: Bicadex
has_related_synonym: Bical
has_related_synonym: Bicalox
has_related_synonym: Bicamide
has_related_synonym: Bicatlon
has_related_synonym: Bicusan
has_related_synonym: Binabic
has_related_synonym: Bypro
has_related_synonym: Calumid
has_related_synonym: Calutide
has_related_synonym: Calutol
has_related_synonym: Casodex
has_related_synonym: Cosudex
has_related_synonym: ICI 176,334
has_related_synonym: ICI 176334
has_related_synonym: ICI-176334
has_related_synonym: Kalumid
has_related_synonym: Ormandyl
has_related_synonym: bicalutamida
has_related_synonym: bicalutamide
has_related_synonym: bicalutamidum
has_related_synonym: racemic bicalutamide
id: CHEBI:3090

Beilstein
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: Beilstein:5364666

ChemIDplus
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: CAS:90357-06-5

NIST Chemistry WebBook
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: CAS:90357-06-5

DrugCentral
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: Drug_Central:367

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:11915584

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:12015321

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:12017896

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:12421104

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:12959312

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:15509184

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:17313204

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:18062751

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:19194583

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:23527766

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:30784326

Europe PMC
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: PMID:31099426

Reaxys
type: Axiom
annotated source: bicalutamide
annotated property: database_cross_reference
annotated target: Reaxys:5364666

trichloroacetic acid
type: Class
subclass of: organic molecular entity
definition: A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
formula: C2HCl3O2
smiles: OC(=O)C(Cl)(Cl)Cl
database_cross_reference: CAS:76-03-9

alclofenac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
database_cross_reference: CAS:22131-79-9
database_cross_reference: Drug_Central:107
database_cross_reference: PMID:18796
database_cross_reference: PMID:19205
database_cross_reference: PMID:21068
database_cross_reference: PMID:236805
database_cross_reference: PMID:237493
database_cross_reference: PMID:241593
database_cross_reference: PMID:241595
database_cross_reference: PMID:241596
database_cross_reference: PMID:241597
database_cross_reference: PMID:241598
database_cross_reference: PMID:241600
database_cross_reference: PMID:241601
database_cross_reference: PMID:241602
database_cross_reference: PMID:241603
database_cross_reference: PMID:24426
database_cross_reference: PMID:4279126
database_cross_reference: PMID:509935
database_cross_reference: PMID:6103793
database_cross_reference: PMID:6106453
database_cross_reference: PMID:6109575
database_cross_reference: PMID:6120697
database_cross_reference: PMID:6141199
database_cross_reference: PMID:7853459
database_cross_reference: PMID:7905004
database_cross_reference: Reaxys:2116510
has_exact_synonym: [3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
has_related_synonym: (4-Allyloxy-3-chlorphenyl)essigsaeure
has_related_synonym: 3-Chloro-4-(2-propenyloxy)benzeneacetic acid
has_related_synonym: [4-(allyloxy)-3-chlorophenyl]acetic acid
has_related_synonym: alclofenac
has_related_synonym: alclofenaco
has_related_synonym: alclofenacum
id: CHEBI:31183

ChemIDplus
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: CAS:22131-79-9

DrugCentral
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: Drug_Central:107

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:18796

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:19205

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:21068

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:236805

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:237493

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241593

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241595

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241596

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241597

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241598

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241600

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241601

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241602

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:241603

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:24426

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:4279126

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:509935

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:6103793

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:6106453

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:6109575

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:6120697

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:6141199

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:7853459

Europe PMC
type: Axiom
annotated source: alclofenac
annotated property: database_cross_reference
annotated target: PMID:7905004

Reaxys
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annotated target: Reaxys:2116510

bendazac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
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subclass of: Restriction
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    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is glycolic acid in which the hydrogen attached to the 2-hydroxy group is replaced by a 1-benzyl-1H-indazol-3-yl group. Although it has anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties and has been used for the treatment of various inflammatory skin disorders, its principal effect is to inhibit the denaturation of proteins. Its lysine salt is used in the management of cataracts.
database_cross_reference: CAS:20187-55-7
database_cross_reference: Drug_Central:303
database_cross_reference: PMID:1809299
database_cross_reference: PMID:2190795
database_cross_reference: PMID:3176111
database_cross_reference: PMID:3508133
database_cross_reference: PMID:3817034
database_cross_reference: PMID:4099158
database_cross_reference: PMID:4389308
database_cross_reference: PMID:5746786
database_cross_reference: PMID:8483582
database_cross_reference: PMID:8736488
database_cross_reference: Reaxys:893958
has_exact_synonym: [(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
has_related_synonym: BRN 0893958
has_related_synonym: EINECS 243-569-2
has_related_synonym: Iwazac
has_related_synonym: UNII-G4AG71204O
has_related_synonym: bendazac
has_related_synonym: bendazaco
has_related_synonym: bendazacum
has_related_synonym: bendazolic acid
id: CHEBI:31257

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Cyclofenil
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subclass of: organic molecular entity
subclass of: Restriction
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    intersection of: TXPO_0004321
    intersection of: Restriction
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database_cross_reference: CAS:2624-43-3
database_cross_reference: Drug_Central:753
has_exact_synonym: Cyclofenil
has_related_synonym: cyclofenyl
has_related_synonym: cyclopenil
has_related_synonym: cyclophenil
has_related_synonym: cyclophenyl
has_related_synonym: fertodur
has_related_synonym: ondogyne
id: CHEBI:31446

DrugCentral
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febuxostat
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subclass of: Restriction
  on property: has attribute
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    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
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definition: A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
database_cross_reference: CAS:144060-53-7
database_cross_reference: DrugBank:DB04854
database_cross_reference: Drug_Central:1137
database_cross_reference: LINCS:LSM-3064
database_cross_reference: PMID:25724536
database_cross_reference: PMID:30844048
database_cross_reference: PMID:30919894
database_cross_reference: PMID:31267805
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database_cross_reference: PMID:31499267
database_cross_reference: PMID:31531831
database_cross_reference: PMID:31560952
has_exact_synonym: 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
has_related_synonym: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
has_related_synonym: Adenuric
has_related_synonym: Donifoxate
has_related_synonym: Febuday
has_related_synonym: Feburic
has_related_synonym: Goturic
has_related_synonym: Goutex
has_related_synonym: TEI 6720
has_related_synonym: TEI-6720
has_related_synonym: TMX 67
has_related_synonym: TMX-67
has_related_synonym: Uloric
has_related_synonym: Zurig
has_related_synonym: febuxostat
has_related_synonym: febuxostatum
id: CHEBI:31596

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DrugCentral
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Europe PMC
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glafenine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: inhibitor
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
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subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
database_cross_reference: Beilstein:497124
database_cross_reference: CAS:3820-67-5
database_cross_reference: Drug_Central:1297
database_cross_reference: LINCS:LSM-4419
database_cross_reference: PMID:19567678
database_cross_reference: PMID:2210868
database_cross_reference: Reaxys:497124
has_exact_synonym: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
has_related_synonym: 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilate
has_related_synonym: 4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride
has_related_synonym: 4-(2'-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
has_related_synonym: Glafenin
has_related_synonym: Glaphenin
has_related_synonym: Glaphenine
has_related_synonym: Glicafan
has_related_synonym: Glifan
has_related_synonym: Glifanan
has_related_synonym: Glycerylaminophenaquine
has_related_synonym: glafenina
has_related_synonym: glafenine
has_related_synonym: glafeninum
id: CHEBI:31653

Beilstein
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ChemIDplus
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NIST Chemistry WebBook
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annotated source: glafenine
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annotated target: CAS:3820-67-5

DrugCentral
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Europe PMC
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Europe PMC
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Reaxys
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lopinavir
type: Class
subclass of: organic molecular entity
definition: A dicarboxylic acid amide in which a parent structure of amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.
formula: C37H48N4O5
database_cross_reference: CAS:192725-17-0
database_cross_reference: DrugBank:DB01601
database_cross_reference: LINCS:LSM-6027
database_cross_reference: MeSH:D061466
has_exact_synonym: (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide

bromobenzene
type: Class
subclass of: organic molecular entity
definition: The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.
formula: C6H5Br
smiles: Brc1ccccc1
database_cross_reference: CAS:108-86-1
database_cross_reference: MetaCyc:BROMOBENZENE
database_cross_reference: PMID:10996478
database_cross_reference: PMID:24318069
database_cross_reference: Reaxys:1236661
database_cross_reference: Wikipedia:Bromobenzene

oxaliplatin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: mutagen
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
database_cross_reference: CAS:61825-94-3
database_cross_reference: CAS:63121-00-6
database_cross_reference: DrugBank:DB00526
database_cross_reference: Gmelin:1046012
database_cross_reference: Gmelin:28892
database_cross_reference: LINCS:LSM-6352
database_cross_reference: PMID:11300320
database_cross_reference: PMID:14755010
database_cross_reference: PMID:15477639
database_cross_reference: PMID:17347561
database_cross_reference: PMID:18440088
database_cross_reference: PMID:19138416
database_cross_reference: PMID:19735649
database_cross_reference: PMID:27756654
database_cross_reference: PMID:28186109
database_cross_reference: PMID:28398406
database_cross_reference: PMID:28415810
database_cross_reference: PMID:28499428
database_cross_reference: PMID:28505615
database_cross_reference: PMID:28624791
database_cross_reference: PMID:28642473
database_cross_reference: PMID:28654098
database_cross_reference: PMID:28695397
database_cross_reference: PMID:28762171
database_cross_reference: PMID:28777427
database_cross_reference: PMID:28800641
database_cross_reference: PMID:28811232
database_cross_reference: PMID:28812173
database_cross_reference: PMID:28837658
database_cross_reference: PMID:28876454
database_cross_reference: PMID:28881354
database_cross_reference: PMID:28881481
database_cross_reference: PMID:28884286
database_cross_reference: PMID:28894576
database_cross_reference: PMID:28924870
database_cross_reference: PMID:28938919
database_cross_reference: Reaxys:15700099
has_exact_synonym: (SP-4-2)[(1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N'][ethanedioato(2-)-kappa(2)O(1),O(2)]platinum
has_exact_synonym: Oxaliplatin
has_related_synonym: (SP-4-2-(1R-trans))-(1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum
has_related_synonym: Eloxatin
has_related_synonym: oxalato(1,2-diaminocyclohexane)platinum(II)
has_related_synonym: oxaliplatin
has_related_synonym: oxaliplatine
has_related_synonym: oxaliplatino
has_related_synonym: oxaliplatinum
id: CHEBI:31941

ChemIDplus
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Gmelin
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Gmelin
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Reaxys
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buprenorphine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003665
definition: A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group.
formula: C29H41NO4
database_cross_reference: CAS:52485-79-7
database_cross_reference: DrugBank:DB00921
database_cross_reference: Wikipedia:Buprenorphine
has_exact_synonym: (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol

Tolvaptan
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:150683-30-0
database_cross_reference: Drug_Central:4110
has_exact_synonym: Tolvaptan
has_related_synonym: OPC 41061
has_related_synonym: OPC-41061
has_related_synonym: jinarc
id: CHEBI:32246

DrugCentral
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amineptine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: dopamine uptake inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
formula: C22H27NO2
smiles: OC(=O)CCCCCCNC1c2ccccc2CCc2ccccc12
database_cross_reference: Beilstein:2170218
database_cross_reference: CAS:57574-09-1
database_cross_reference: DrugBank:DB04836
database_cross_reference: Drug_Central:161
database_cross_reference: PMID:2131927
database_cross_reference: PMID:2141246
database_cross_reference: PMID:2698268
database_cross_reference: PMID:7609861
database_cross_reference: PMID:9347390
database_cross_reference: Reaxys:2170218
database_cross_reference: Wikipedia:Amineptine
has_exact_synonym: 7-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid
has_related_synonym: Amineptin
has_related_synonym: Survector
has_related_synonym: amineptine
has_related_synonym: amineptino
has_related_synonym: amineptinum
id: CHEBI:32499

Beilstein
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ChemIDplus
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NIST Chemistry WebBook
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DrugCentral
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Europe PMC
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Europe PMC
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Europe PMC
type: Axiom
annotated source: amineptine
annotated property: database_cross_reference
annotated target: PMID:9347390

Reaxys
type: Axiom
annotated source: amineptine
annotated property: database_cross_reference
annotated target: Reaxys:2170218

pirinixic acid
type: Class
subclass of: organic molecular entity
formula: C14H14ClN3O2S
formula: Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C
smiles: Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C
database_cross_reference: CAS:50892-23-4
database_cross_reference: LINCS:LSM-2015
database_cross_reference: PubChem:17396608
database_cross_reference: Wikipedia:Pirinixic_Acid
has_exact_synonym: ({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid
has_exact_synonym: WY14643

lysophosphatidic acids
type: Class
subclass of: monoacylglycerol phosphate
definition: Any monoacylglycerol phosphate obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid or derivatives therein.

long-chain fatty acyl-CoA
type: Class
subclass of: fatty acyl-CoA
definition: A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any long-chain (C13 to C22) fatty acid.
formula: C22H35N7O17P3SR
database_cross_reference: PMID:10224157
database_cross_reference: PMID:14516204
database_cross_reference: PMID:16357361
database_cross_reference: PMID:17652214
has_exact_synonym: LCFA-coenzyme A

antitubercular agent
type: Class
subclass of: antimycobacterial drug
definition: A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
has_related_synonym: antitubercular
has_related_synonym: antitubercular agents
has_related_synonym: antitubercular drug
has_related_synonym: antitubercular drugs
has_related_synonym: tuberculostatic agent
id: CHEBI:33231

atom
type: Class
subclass of: chemical entity
definition: A chemical entity constituting the smallest component of an element having the chemical properties of the element.

molecular messenger
type: Class
subclass of: biological role
subclass of: TXPO_0001393
has_related_synonym: chemical messenger
id: CHEBI:33280

antimicrobial agent
type: Class
subclass of: biological role
subclass of: pharmacological role
definition: A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
database_cross_reference: PMID:12964249
database_cross_reference: PMID:22117953
database_cross_reference: PMID:22439833
database_cross_reference: PMID:22849268
database_cross_reference: PMID:22849276
database_cross_reference: PMID:22958833
has_related_synonym: Antibiotika
has_related_synonym: Antibiotikum
has_related_synonym: antibiotic
has_related_synonym: antibiotics
has_related_synonym: antibiotique
has_related_synonym: antimicrobial
has_related_synonym: antimicrobial agents
has_related_synonym: antimicrobials
has_related_synonym: microbicide
has_related_synonym: microbicides
id: CHEBI:33281

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:12964249

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:22117953

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:22439833

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:22849268

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:22849276

Europe PMC
type: Axiom
annotated source: antimicrobial agent
annotated property: database_cross_reference
annotated target: PMID:22958833

antibacterial agent
type: Class
subclass of: antimicrobial agent
definition: A substance (or active part thereof) that kills or slows the growth of bacteria.
definition: A substance that kills or slows the growth of bacteria.
has_related_synonym: antibacterial agents
has_related_synonym: antibacterials
has_related_synonym: bactericide
has_related_synonym: bactericides
id: CHEBI:33282

food role
type: Class
subclass of: biological role
definition: Any material that can be ingested by an organism.

metal atom
type: Class
subclass of: atom

biomacromolecule
type: Class
subclass of: polyatomic entity
definition: A macromolecule formed by a living organism.

nucleic acid
type: Class
subclass of: polynucleotide
definition: A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
imported from: chebi.owl

ribonucleic acid
type: Class
subclass of: nucleic acid
editor preferred term: ribonucleic acid
definition: High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
imported from: chebi.owl
has_exact_synonym: RNA

amino acid
type: Class
subclass of: organic molecule
definition: A carboxylic acid containing one or more amino groups.
comment: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

Axiom
annotated source: amino acid
annotated property: comment
annotated target: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
database_cross_reference: MeSH:D000596

nucleoside
type: Class
subclass of: organic molecule
subclass of: IMR_0001698
definition: An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.

phenols
type: Class
subclass of: organic molecular entity
definition: Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
formula: C6HOR5
smiles: C1(=C(C(=C(C(=C1*)*)*)*)*)O
database_cross_reference: Wikipedia:Phenols
has_related_synonym: Aryl alcohol

carbamazepine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimanic drug
subclass of: Restriction
  on property: has role
  some values from: analgesic
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
database_cross_reference: Beilstein:1246090
database_cross_reference: CAS:298-46-4
database_cross_reference: DrugBank:DB00564
database_cross_reference: Drug_Central:489
database_cross_reference: LINCS:LSM-3610
database_cross_reference: PMID:10411478
database_cross_reference: PMID:11071486
database_cross_reference: PMID:11129121
database_cross_reference: PMID:11240598
database_cross_reference: PMID:11475584
database_cross_reference: PMID:11595204
database_cross_reference: PMID:11888243
database_cross_reference: PMID:11891095
database_cross_reference: PMID:12073283
database_cross_reference: PMID:12228880
database_cross_reference: PMID:12475188
database_cross_reference: PMID:12749779
database_cross_reference: PMID:12799799
database_cross_reference: PMID:12957643
database_cross_reference: PMID:14160216
database_cross_reference: PMID:14572037
database_cross_reference: PMID:14581052
database_cross_reference: PMID:14713026
database_cross_reference: PMID:14723323
database_cross_reference: PMID:15165631
database_cross_reference: PMID:15557493
database_cross_reference: PMID:15665743
database_cross_reference: PMID:15683742
database_cross_reference: PMID:15739418
database_cross_reference: PMID:15820347
database_cross_reference: PMID:15850602
database_cross_reference: PMID:16033627
database_cross_reference: PMID:16150575
database_cross_reference: PMID:16245817
database_cross_reference: PMID:16380297
database_cross_reference: PMID:16394456
database_cross_reference: PMID:16437428
database_cross_reference: PMID:16538175
database_cross_reference: PMID:16562645
database_cross_reference: PMID:16616830
database_cross_reference: PMID:16990009
database_cross_reference: PMID:17027750
database_cross_reference: PMID:17028629
database_cross_reference: PMID:17207414
database_cross_reference: PMID:17582711
database_cross_reference: PMID:17873967
database_cross_reference: PMID:17949959
database_cross_reference: PMID:18163657
database_cross_reference: PMID:18415623
database_cross_reference: PMID:18637155
database_cross_reference: PMID:18652684
database_cross_reference: PMID:18656520
database_cross_reference: PMID:18969759
database_cross_reference: PMID:19135617
database_cross_reference: PMID:19473818
database_cross_reference: PMID:19741433
database_cross_reference: PMID:19921623
database_cross_reference: PMID:22322005
database_cross_reference: PMID:27967303
database_cross_reference: PMID:7602118
database_cross_reference: Reaxys:1246090
has_exact_synonym: 5H-dibenzo[b,f]azepine-5-carboxamide
has_related_synonym: 5-Carbamoyl-5H-dibenz(b,f)azepine
has_related_synonym: 5-Carbamoyl-5H-dibenzo(b,f)azepine
has_related_synonym: 5-Carbamyl-5H-dibenzo(b,f)azepine
has_related_synonym: 5-carbamoyl-5H-dibenz[b,f]azepine
has_related_synonym: 5H-Dibenz(b,f)azepine-5-carboxamide
has_related_synonym: Carbamazepen
has_related_synonym: Carnexiv
has_related_synonym: carbamazepina
has_related_synonym: carbamazepine
has_related_synonym: carbamazepinum
id: CHEBI:3387

Beilstein
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: Beilstein:1246090

ChemIDplus
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: CAS:298-46-4

NIST Chemistry WebBook
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: CAS:298-46-4

DrugCentral
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: Drug_Central:489

ChEMBL
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:10411478

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11071486

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11129121

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11240598

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11475584

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11595204

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11888243

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:11891095

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12073283

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12228880

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12475188

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12749779

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12799799

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:12957643

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:14160216

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:14572037

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:14581052

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:14713026

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:14723323

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15165631

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15557493

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15665743

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15683742

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15739418

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15820347

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:15850602

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16033627

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16150575

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16245817

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16380297

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16394456

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16437428

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16538175

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16562645

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16616830

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:16990009

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17027750

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17028629

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17207414

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17582711

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17873967

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:17949959

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18163657

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18415623

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18637155

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18652684

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18656520

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:18969759

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:19135617

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:19473818

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:19741433

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:19921623

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:22322005

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:27967303

Europe PMC
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: PMID:7602118

Reaxys
type: Axiom
annotated source: carbamazepine
annotated property: database_cross_reference
annotated target: Reaxys:1246090

benzarone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:1477-19-6
database_cross_reference: Drug_Central:317
has_exact_synonym: Benzarone
has_related_synonym: 2-Ethyl-3-(4-hydroxybenzoyl)benzofuran
has_related_synonym: benzaron
id: CHEBI:34559

DrugCentral
type: Axiom
annotated source: benzarone
annotated property: database_cross_reference
annotated target: Drug_Central:317

N-nitrosodiethylamine
type: Class
subclass of: organic molecular entity
definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
formula: C4H10N2O
smiles: CCN(CC)N=O
database_cross_reference: CAS:55-18-5
has_exact_synonym: N-ethyl-N-nitrosoethanamine
has_related_synonym: DEN
has_related_synonym: Diethylnitrosamine

antimetabolite
type: Class
subclass of: biochemical role
definition: A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
has_exact_synonym: antimetabolite
has_related_synonym: antimetabolites
id: CHEBI:35221

inhibitor
type: Class
equivalent class: Class
  intersection of: role
  intersection of: Restriction
    on property: capable of negatively regulating
    some values from: process
subclass of: biological role
subclass of: TXPO_0003710
definition: A substance that diminishes the rate of a chemical reaction.
has_exact_synonym: inhibitor
has_related_synonym: inhibidor
has_related_synonym: inhibiteur
has_related_synonym: inhibitors
id: CHEBI:35222

catalyst
type: Class
subclass of: chemical role
definition: A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.

central nervous system stimulant
type: Class
subclass of: central nervous system drug
definition: Any drug that enhances the activity of the central nervous system.
has_exact_synonym: central nervous system stimulant
has_related_synonym: CNS stimulant
has_related_synonym: analeptic
has_related_synonym: analeptic agent
has_related_synonym: analeptic drug
has_related_synonym: analeptics
has_related_synonym: central stimulant
id: CHEBI:35337

steroid
type: Class
subclass of: lipid
definition: Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from triterpenoids.
database_cross_reference: SMILES: C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C
has_exact_synonym: steroids

monosaccharide
type: Class
subclass of: carbohydrate
definition: Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.
has_exact_synonym: Monosaccharide
has_exact_synonym: monosaccharide
has_exact_synonym: monosaccharides

antiinfective agent
type: Class
subclass of: drug
definition: A substance used in the prophylaxis or therapy of infectious diseases.
has_related_synonym: anti-infective agents
has_related_synonym: anti-infective drugs
has_related_synonym: antiinfective agents
has_related_synonym: antiinfective drug
id: CHEBI:35441

antiparasitic agent
type: Class
subclass of: antiinfective agent
definition: A substance used to treat or prevent parasitic infections.
has_related_synonym: antiparasitic drugs
has_related_synonym: antiparasitics
has_related_synonym: parasiticides
id: CHEBI:35442

anthelminthic drug
type: Class
subclass of: antiparasitic agent
definition: Substance intended to kill parasitic worms (helminths).
has_exact_synonym: anthelminthic
has_related_synonym: anthelminthics
has_related_synonym: anthelmintic
has_related_synonym: anthelmintics
has_related_synonym: antihelminth
has_related_synonym: antihelmintico
has_related_synonym: vermifuge
id: CHEBI:35443

antinematodal drug
type: Class
subclass of: nematicide
subclass of: anthelminthic drug
definition: A substance used in the treatment or control of nematode infestations.
has_related_synonym: antinematodal agent
has_related_synonym: antinematodal drugs
has_related_synonym: antinematodals
id: CHEBI:35444

antidepressant
type: Class
subclass of: psychotropic drug
definition: Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
has_related_synonym: antidepressant drugs
has_related_synonym: antidepressants
has_related_synonym: thymoanaleptics
has_related_synonym: thymoleptic drugs
has_related_synonym: thymoleptics
id: CHEBI:35469

central nervous system drug
type: Class
subclass of: drug
definition: A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
has_related_synonym: CNS agent
has_related_synonym: CNS drugs
has_related_synonym: central nervous system agents
id: CHEBI:35470

psychotropic drug
type: Class
subclass of: central nervous system drug
definition: A loosely defined grouping of drugs that have effects on psychological function.
database_cross_reference: Wikipedia:Psychotropic_drug
has_related_synonym: psychoactive agent
has_related_synonym: psychoactive drugs
has_related_synonym: psychopharmaceuticals
has_related_synonym: psychotropic drugs
id: CHEBI:35471

anti-inflammatory drug
type: Class
subclass of: drug
definition: A substance that reduces or suppresses inflammation.
has_related_synonym: anti-inflammatory drugs
has_related_synonym: antiinflammatory agent
has_related_synonym: antiinflammatory drug
has_related_synonym: antiinflammatory drugs
id: CHEBI:35472

tranquilizing drug
type: Class
subclass of: psychotropic drug
subclass of: central nervous system depressant
definition: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.
has_related_synonym: ataractics
has_related_synonym: tranquilising drug
has_related_synonym: tranquilizing drugs
has_related_synonym: tranquillising agent
has_related_synonym: tranquillizing agents
id: CHEBI:35473

anxiolytic drug
type: Class
subclass of: tranquilizing drug
definition: Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
has_related_synonym: anti-anxiety agents
has_related_synonym: anti-anxiety drugs
has_related_synonym: anxiolytic agents
has_related_synonym: anxiolytics
has_related_synonym: minor tranquilisers
has_related_synonym: minor tranquilizers
has_related_synonym: minor tranquilizing agents
id: CHEBI:35474

non-steroidal anti-inflammatory drug
type: Class
subclass of: anti-inflammatory drug
subclass of: antirheumatic drug
definition: An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
database_cross_reference: Wikipedia:Non-steroidal_anti-inflammatory_drug
has_related_synonym: NSAID
has_related_synonym: NSAIDs
has_related_synonym: non-steroidal anti-inflammatory agent
has_related_synonym: non-steroidal anti-inflammatory drugs
id: CHEBI:35475

antipsychotic agent
type: Class
subclass of: tranquilizing drug
definition: Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
has_related_synonym: Neuroleptikum
has_related_synonym: antipsychotic agents
has_related_synonym: antipsychotic drug
has_related_synonym: antipsychotic drugs
has_related_synonym: antipsychotics
has_related_synonym: antipsychotiques
has_related_synonym: grosser Tranquilizer
has_related_synonym: major tranquilizers
has_related_synonym: major tranquilizing agents
has_related_synonym: neuroleptic
has_related_synonym: neuroleptic agents
has_related_synonym: neuroleptics
has_related_synonym: neuroleptique
has_related_synonym: neuroleptiques
id: CHEBI:35476

antimanic drug
type: Class
subclass of: tranquilizing drug
definition: Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
has_related_synonym: antimanic agent
has_related_synonym: antimanic drugs
has_related_synonym: antimanics
id: CHEBI:35477

analgesic
type: Class
subclass of: drug
subclass of: pharmacological role
definition: An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
id: CHEBI:35480

non-narcotic analgesic
type: Class
subclass of: analgesic
definition: A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
id: CHEBI:35481

EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
type: Class
subclass of: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
definition: An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of aldehyde dehydrogenase (NAD(+)), EC 1.2.1.3.
has_related_synonym: CoA-independent aldehyde dehydrogenase inhibitor
has_related_synonym: CoA-independent aldehyde dehydrogenase inhibitors
has_related_synonym: EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitor
has_related_synonym: EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitors
has_related_synonym: EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitors
has_related_synonym: EC 1.2.1.3 inhibitor
has_related_synonym: EC 1.2.1.3 inhibitors
has_related_synonym: NAD-aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-aldehyde dehydrogenase inhibitors
has_related_synonym: NAD-dependent 4-hydroxynonenal dehydrogenase inhibitor
has_related_synonym: NAD-dependent 4-hydroxynonenal dehydrogenase inhibitors
has_related_synonym: NAD-dependent aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-dependent aldehyde dehydrogenase inhibitors
has_related_synonym: NAD-linked aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-linked aldehyde dehydrogenase inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD(+)) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD(+)) inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD) inhibitors
has_related_synonym: aldehyde dehydrogenase inhibitor
has_related_synonym: aldehyde dehydrogenase inhibitors
has_related_synonym: m-methylbenzaldehyde dehydrogenase inhibitor
has_related_synonym: m-methylbenzaldehyde dehydrogenase inhibitors
has_related_synonym: propionaldehyde dehydrogenase inhibitor
has_related_synonym: propionaldehyde dehydrogenase inhibitors
id: CHEBI:35487

central nervous system depressant
type: Class
subclass of: central nervous system drug
definition: A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
has_related_synonym: CNS depressants
has_related_synonym: central nervous system depressants
id: CHEBI:35488

antipyretic
type: Class
subclass of: drug
definition: A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
has_related_synonym: anti-pyretic
id: CHEBI:35493

androgen antagonist
type: Class
subclass of: drug
subclass of: hormone antagonist
definition: A compound which inhibits or antagonises the biosynthesis or actions of androgens.
has_related_synonym: antiandrogen
id: CHEBI:35497

diuretic
type: Class
subclass of: drug
definition: An agent that promotes the excretion of urine through its effects on kidney function.
has_related_synonym: diuretics
id: CHEBI:35498

hypoglycemic agent
type: Class
subclass of: drug
definition: A drug which lowers the blood glucose level.
has_related_synonym: antidiabetic
has_related_synonym: antihyperglycemic
has_related_synonym: antihyperglycemic agent
has_related_synonym: antihyperglycemic agents
has_related_synonym: antihyperglycemic drug
has_related_synonym: antihyperglycemic drugs
has_related_synonym: antihyperglycemics
has_related_synonym: hypoglycemic agents
has_related_synonym: hypoglycemic drug
has_related_synonym: hypoglycemic drugs
id: CHEBI:35526

beta-adrenergic antagonist
type: Class
subclass of: adrenergic antagonist
subclass of: beta-adrenergic drug
definition: An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
has_related_synonym: beta-adrenergic antagonists
has_related_synonym: beta-adrenergic blocker
has_related_synonym: beta-adrenergic blockers
has_related_synonym: beta-adrenergic receptor blockaders
has_related_synonym: beta-adrenoceptor antagonists
has_related_synonym: beta-blocker
has_related_synonym: beta-blockers
id: CHEBI:35530

EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
type: Class
subclass of: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
definition: A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
has_related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor
has_related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors
has_related_synonym: (PG)H synthase inhibitor
has_related_synonym: (PG)H synthase inhibitors
has_related_synonym: COX inhibitor
has_related_synonym: EC 1.14.99.1 (cyclooxygenase) inhibitor
has_related_synonym: EC 1.14.99.1 (cyclooxygenase) inhibitors
has_related_synonym: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors
has_related_synonym: EC 1.14.99.1 inhibitor
has_related_synonym: EC 1.14.99.1 inhibitors
has_related_synonym: PG synthetase inhibitor
has_related_synonym: PG synthetase inhibitors
has_related_synonym: cyclooxygenase (EC 1.14.99.1) inhibitor
has_related_synonym: cyclooxygenase (EC 1.14.99.1) inhibitors
has_related_synonym: cyclooxygenase inhibitor
has_related_synonym: cyclooxygenase inhibitors
has_related_synonym: fatty acid cyclooxygenase inhibitor
has_related_synonym: fatty acid cyclooxygenase inhibitors
has_related_synonym: prostaglandin G/H synthase inhibitor
has_related_synonym: prostaglandin G/H synthase inhibitors
has_related_synonym: prostaglandin endoperoxide synthetase inhibitor
has_related_synonym: prostaglandin endoperoxide synthetase inhibitors
has_related_synonym: prostaglandin synthase inhibitor
has_related_synonym: prostaglandin synthase inhibitors
has_related_synonym: prostaglandin synthetase inhibitor
has_related_synonym: prostaglandin synthetase inhibitors
id: CHEBI:35544

Perfluorooctanoic acid
type: Class
subclass of: organic molecular entity
definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
formula: C8HF15O2
database_cross_reference: CAS:335-67-1
database_cross_reference: Wikipedia:Perfluorooctanoic_acid
has_exact_synonym: PFOA
has_exact_synonym: pentadecafluorooctanoic acid
has_exact_synonym: perfluorooctanoate

perhexiline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: cardiovascular drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. (by Wikipedia)
formula: C19H35N
smiles: C1CCC(CC1)C(CC1CCCCN1)C1CCCCC1
database_cross_reference: Beilstein:4979856
database_cross_reference: CAS:6621-47-2
database_cross_reference: DrugBank:DB01074
database_cross_reference: Drug_Central:2106
database_cross_reference: LINCS:LSM-4353
database_cross_reference: Wikipedia:Perhexiline
has_exact_synonym: 2-(2,2-dicyclohexylethyl)piperidine
has_exact_synonym: Perhexiline
has_related_synonym: Perhexilene
id: CHEBI:35553

Beilstein
type: Axiom
annotated source: perhexiline
annotated property: database_cross_reference
annotated target: Beilstein:4979856

ChemIDplus
type: Axiom
annotated source: perhexiline
annotated property: database_cross_reference
annotated target: CAS:6621-47-2

NIST Chemistry WebBook
type: Axiom
annotated source: perhexiline
annotated property: database_cross_reference
annotated target: CAS:6621-47-2

DrugCentral
type: Axiom
annotated source: perhexiline
annotated property: database_cross_reference
annotated target: Drug_Central:2106

cardiovascular drug
type: Class
subclass of: drug
definition: A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
has_related_synonym: cardiovascular agent
has_related_synonym: cardiovascular drugs
id: CHEBI:35554

alpha-adrenergic agonist
type: Class
subclass of: adrenergic agonist
subclass of: alpha-adrenergic drug
definition: An agent that selectively binds to and activates alpha-adrenergic receptors.
has_related_synonym: alpha-adrenergic agonists
has_related_synonym: alpha-adrenergic receptor agonist
has_related_synonym: alpha-adrenoceptor agonists
id: CHEBI:35569

phorone
type: Class
subclass of: organic molecular entity
formula: C9H14O
smiles: CC(C)=CC(=O)C=C(C)C
database_cross_reference: CAS:504-20-1
has_exact_synonym: 2,6-dimethylhepta-2,5-dien-4-one

antineoplastic agent
type: Class
subclass of: drug
definition: A substance that inhibits or prevents the proliferation of neoplasms.
has_related_synonym: anticancer agent
has_related_synonym: anticancer agents
has_related_synonym: antineoplastic
has_related_synonym: antineoplastic agents
has_related_synonym: cytostatic
id: CHEBI:35610

vasodilator agent
type: Class
subclass of: cardiovascular drug
definition: A drug used to cause dilation of the blood vessels.
has_related_synonym: vasodilator
has_related_synonym: vasodilator agents
id: CHEBI:35620

anticonvulsant
type: Class
subclass of: central nervous system depressant
definition: A drug used to prevent seizures or reduce their severity.
has_related_synonym: Antiepileptika
has_related_synonym: Antiepileptikum
has_related_synonym: Antikonvulsiva
has_related_synonym: Antikonvulsivum
has_related_synonym: anti-convulsant
has_related_synonym: anti-convulsants
has_related_synonym: anti-convulsive agent
has_related_synonym: anti-convulsive agents
has_related_synonym: anticonvulsants
has_related_synonym: anticonvulsive agent
has_related_synonym: anticonvulsive agents
has_related_synonym: antiepileptic
has_related_synonym: antiepileptics
has_related_synonym: antiepileptique
has_related_synonym: antiepileptiques
id: CHEBI:35623

EC 1.17.3.2 (xanthine oxidase) inhibitor
type: Class
subclass of: EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor
definition: An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).
has_related_synonym: EC 1.17.3.2 (xanthine oxidase) inhibitors
has_related_synonym: EC 1.17.3.2 inhibitor
has_related_synonym: EC 1.17.3.2 inhibitors
has_related_synonym: Schardinger enzyme inhibitor
has_related_synonym: Schardinger enzyme inhibitors
has_related_synonym: hypoxanthine oxidase inhibitor
has_related_synonym: hypoxanthine oxidase inhibitors
has_related_synonym: hypoxanthine-xanthine oxidase inhibitor
has_related_synonym: hypoxanthine-xanthine oxidase inhibitors
has_related_synonym: hypoxanthine:oxygen oxidoreductase inhibitor
has_related_synonym: hypoxanthine:oxygen oxidoreductase inhibitors
has_related_synonym: xanthine oxidase (EC 1.17.3.2) inhibitor
has_related_synonym: xanthine oxidase (EC 1.17.3.2) inhibitors
has_related_synonym: xanthine oxidase inhibitor
has_related_synonym: xanthine oxidase inhibitors
has_related_synonym: xanthine oxidoreductase inhibitor
has_related_synonym: xanthine oxidoreductase inhibitors
has_related_synonym: xanthine:O2 oxidoreductase inhibitor
has_related_synonym: xanthine:O2 oxidoreductase inhibitors
has_related_synonym: xanthine:oxygen oxidoreductase inhibitor
has_related_synonym: xanthine:oxygen oxidoreductase inhibitors
has_related_synonym: xanthine:xanthine oxidase inhibitor
has_related_synonym: xanthine:xanthine oxidase inhibitors
id: CHEBI:35634

adrenergic uptake inhibitor
type: Class
subclass of: adrenergic agent
definition: Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
has_related_synonym: ARI
has_related_synonym: NERI
has_related_synonym: NRI
has_related_synonym: adrenergic reuptake inhibitor
has_related_synonym: adrenergic reuptake inhibitors
has_related_synonym: adrenergic uptake inhibitors
has_related_synonym: norepinephrine reuptake inhibitor
has_related_synonym: norepinephrine reuptake inhibitors
id: CHEBI:35640

HIV protease inhibitor
type: Class
subclass of: antiviral drug
subclass of: protease inhibitor
subclass of: anti-HIV agent
definition: An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly.
database_cross_reference: Wikipedia:Protease_inhibitor_(pharmacology)
has_related_synonym: HIV protease inhibitors
id: CHEBI:35660

antihypertensive agent
type: Class
subclass of: cardiovascular drug
definition: Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
has_related_synonym: antihypertensive
has_related_synonym: antihypertensive agents
has_related_synonym: antihypertensive drug
has_related_synonym: antihypertensive drugs
id: CHEBI:35674

antilipemic drug
type: Class
subclass of: drug
definition: A substance used to treat hyperlipidemia (an excess of lipids in the blood).
has_related_synonym: antihyperlipemic
has_related_synonym: antihyperlipemics
has_related_synonym: antihyperlipidemic
has_related_synonym: antihyperlipidemic agent
has_related_synonym: antihyperlipidemic agents
has_related_synonym: antihyperlipidemic drug
has_related_synonym: antihyperlipidemic drugs
has_related_synonym: antihyperlipidemics
has_related_synonym: antilipemic
has_related_synonym: antilipemic drugs
has_related_synonym: antilipemics
has_related_synonym: hypolipidemic agent
has_related_synonym: hypolipidemic agents
id: CHEBI:35679

xenobiotic
type: Class
subclass of: biological role
definition: A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
database_cross_reference: Wikipedia:Xenobiotic
has_exact_synonym: Xenobiotic
has_exact_synonym: xenobiotic
has_exact_synonym: xenobiotics
has_related_synonym: xenobiotic compounds
id: CHEBI:35703

Axiom
annotated source: xenobiotic
annotated property: has_exact_synonym
annotated target: xenobiotics
database_cross_reference: IUPAC

immunosuppressive agent
type: Class
subclass of: immunomodulator
definition: An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
has_related_synonym: immunosuppressant
has_related_synonym: immunosuppressive agents
has_related_synonym: inmunosupresor
id: CHEBI:35705

sedative
type: Class
subclass of: central nervous system depressant
definition: A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
has_related_synonym: hypnotics
has_related_synonym: hypnotics and sedatives
has_related_synonym: sedative drug
has_related_synonym: sedatives
has_related_synonym: sedatives and hypnotics
id: CHEBI:35717

antifungal agent
type: Class
subclass of: antimicrobial agent
definition: An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
has_related_synonym: antifungal
has_related_synonym: antifungal agents
has_related_synonym: antifungal drug
has_related_synonym: antifungal drugs
has_related_synonym: antifungals
id: CHEBI:35718

glycerolipid
type: Class
subclass of: lipid
definition: Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.
database_cross_reference: IMR:0001382

glycerophosphoserine
type: Class
subclass of: glycerophospholipid

phosphosphingolipid
type: Class
subclass of: phospholipid
subclass of: sphingolipid
database_cross_reference: http://purl.obolibrary.org/obo/IMR_0001383
has_exact_synonym: sphingophospholipid

leprostatic drug
type: Class
subclass of: antimycobacterial drug
definition: A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions.
has_related_synonym: leprostatic
has_related_synonym: leprostatic agent
has_related_synonym: leprostatic drugs
id: CHEBI:35816

antiprotozoal drug
type: Class
subclass of: antiparasitic agent
subclass of: antimicrobial drug
definition: Any antimicrobial drug which is used to treat or prevent protozoal infections.
has_related_synonym: antiprotozoal agent
has_related_synonym: antiprotozoal agents
has_related_synonym: antiprotozoal drugs
id: CHEBI:35820

anticholesteremic drug
type: Class
subclass of: antilipemic drug
definition: A substance used to lower plasma cholesterol levels.

uricosuric drug
type: Class
subclass of: gout suppressant
subclass of: renal agent
definition: A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
has_related_synonym: uricosuric agent
has_related_synonym: uricosuric drugs
id: CHEBI:35841

antirheumatic drug
type: Class
subclass of: drug
definition: A drug used to treat rheumatoid arthritis.
has_related_synonym: anti-rheumatic drugs
has_related_synonym: antirheumatic agent
has_related_synonym: antirheumatic drugs
id: CHEBI:35842

gout suppressant
type: Class
subclass of: antirheumatic drug
definition: A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout.
has_related_synonym: gout suppressants
id: CHEBI:35845

renal agent
type: Class
subclass of: drug
definition: A drug used for its effect on the kidneys' regulation of body fluid composition and volume.
has_related_synonym: renal agents
id: CHEBI:35846

lipoxygenase inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
definition: A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
has_related_synonym: lipooxygenase inhibitor
has_related_synonym: lipoxygenase inhibitors
id: CHEBI:35856

neurotransmitter agent
type: Class
subclass of: drug
subclass of: pharmacological role
definition: A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
has_related_synonym: neurotransmitter agents
id: CHEBI:35942

antimicrobial drug
type: Class
subclass of: antimicrobial agent
subclass of: antiinfective agent
definition: A drug used to treat or prevent microbial infections.
has_related_synonym: antimicrobial drugs
id: CHEBI:36043

antiviral drug
type: Class
subclass of: antiviral agent
subclass of: antimicrobial agent
subclass of: antimicrobial drug
definition: A substance used in the prophylaxis or therapy of virus diseases.
has_related_synonym: anti-viral drug
has_related_synonym: anti-virus drug
has_related_synonym: antiviral drugs
id: CHEBI:36044

antibacterial drug
type: Class
subclass of: antibacterial agent
subclass of: antimicrobial drug
definition: A drug used to treat or prevent bacterial infections.
database_cross_reference: Wikipedia:Antibacterial
has_related_synonym: antibacterial drugs
id: CHEBI:36047

protein
type: Class
subclass of: peptide
subclass of: biomacromolecule
definition: An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA.
database_cross_reference: http://purl.obolibrary.org/obo/PR_000000001

chlormezanone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anxiolytic drug
subclass of: Restriction
  on property: has role
  some values from: antipsychotic agent
subclass of: Restriction
  on property: has role
  some values from: muscle relaxant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions.
database_cross_reference: Beilstein:23033
database_cross_reference: CAS:80-77-3
database_cross_reference: DrugBank:DB01178
database_cross_reference: Drug_Central:603
database_cross_reference: LINCS:LSM-4356
database_cross_reference: PMID:10191862
database_cross_reference: PMID:10412893
database_cross_reference: PMID:10798243
database_cross_reference: PMID:15897685
database_cross_reference: PMID:29438107
database_cross_reference: PMID:3449070
database_cross_reference: PMID:3720548
database_cross_reference: PMID:3768082
database_cross_reference: PMID:6403110
database_cross_reference: PMID:7104168
database_cross_reference: PMID:7758315
database_cross_reference: PMID:9770210
database_cross_reference: Reaxys:23033
has_exact_synonym: 2-(4-chlorophenyl)-3-methyl-1,3-thiazinan-4-one 1,1-dioxide
has_related_synonym: (+-)-chlormezanone
has_related_synonym: 2-(p-chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
has_related_synonym: 2-(p-chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
has_related_synonym: chlormethazanone
has_related_synonym: chlormezanona
has_related_synonym: chlormezanone
has_related_synonym: chlormezanonum
id: CHEBI:3619

Beilstein
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: Beilstein:23033

ChemIDplus
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: CAS:80-77-3

DrugCentral
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: Drug_Central:603

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:10191862

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:10412893

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:10798243

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:15897685

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:29438107

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:3449070

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:3720548

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:3768082

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:6403110

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:7104168

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:7758315

Europe PMC
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: PMID:9770210

Reaxys
type: Axiom
annotated source: chlormezanone
annotated property: database_cross_reference
annotated target: Reaxys:23033

glycerophosphoethanolamine
type: Class
subclass of: phosphoethanolamine
subclass of: glycerophospholipid

glycerophosphoinositol
type: Class
subclass of: glycerophospholipid
definition: Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.
database_cross_reference: PMID:14706866
has_related_synonym: glycerophosphoinositols

trypanocidal drug
type: Class
subclass of: antiprotozoal drug
definition: A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
has_related_synonym: antitrypanosomal agent
has_related_synonym: antitrypanosomal agents
has_related_synonym: antitrypanosomal drug
has_related_synonym: antitrypanosomal drugs
has_related_synonym: trypanocidal drugs
has_related_synonym: trypanocide
has_related_synonym: trypanosomicidal agents
id: CHEBI:36335

polyatomic entity
type: Class
subclass of: molecular entity
definition: Any molecular entity consisting of more than one atom.

dichloroacetic acid
type: Class
subclass of: organic molecular entity
definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
formula: C2H2Cl2O2
smiles: OC(=O)C(Cl)Cl
database_cross_reference: CAS:79-43-6
database_cross_reference: Wikipedia:Dichloroacetic_acid

anabolic agent
type: Class
subclass of: hormone
definition: A compound which stimulates anabolism and inhibits catabolism. Anabolic agents stimulate the development of muscle mass, strength, and power.
id: CHEBI:36413

chlorpromazine
type: Class
subclass of: organic molecular entity
definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
formula: C17H19ClN2S
smiles: CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
database_cross_reference: CAS:50-53-3
database_cross_reference: DrugBank:DB00477
database_cross_reference: LINCS:LSM-4017
has_exact_synonym: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine

chlorzoxazone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: sedative
subclass of: Restriction
  on property: has role
  some values from: muscle relaxant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
database_cross_reference: Beilstein:638882
database_cross_reference: CAS:95-25-0
database_cross_reference: DrugBank:DB00356
database_cross_reference: Drug_Central:626
database_cross_reference: LINCS:LSM-6011
database_cross_reference: PMID:10640318
database_cross_reference: PMID:11727787
database_cross_reference: PMID:12437348
database_cross_reference: PMID:16763012
database_cross_reference: PMID:16859676
database_cross_reference: PMID:17621748
database_cross_reference: PMID:21195386
database_cross_reference: PMID:23975871
database_cross_reference: PMID:24210069
database_cross_reference: PMID:25815637
database_cross_reference: PMID:6631711
database_cross_reference: Reaxys:638882
has_exact_synonym: 5-chloro-1,3-benzoxazol-2-ol
has_exact_synonym: CHLORZOXAZONE
has_exact_synonym: Chlorzoxazone
has_related_synonym: 2-hydroxy-5-chlorobenzoxazole
has_related_synonym: 5-chloro-2(3H)-benzoxazolone
has_related_synonym: 5-chloro-2-benzoxazolinone
has_related_synonym: 5-chloro-2-benzoxazolol
has_related_synonym: 5-chloro-2-benzoxazolone
has_related_synonym: 5-chloro-2-hydroxybenzoxazole
has_related_synonym: 5-chlorobenzoxazolidone
has_related_synonym: 5-chlorobenzoxazolin-2-one
has_related_synonym: chlorzoxane
has_related_synonym: chlorzoxazona
has_related_synonym: chlorzoxazone
has_related_synonym: chlorzoxazonum
id: CHEBI:3655

Beilstein
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: Beilstein:638882

ChemIDplus
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: CAS:95-25-0

NIST Chemistry WebBook
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: CAS:95-25-0

DrugCentral
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: Drug_Central:626

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:10640318

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:11727787

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:12437348

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:16763012

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:16859676

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:17621748

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:21195386

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:23975871

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:24210069

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:25815637

Europe PMC
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: PMID:6631711

Reaxys
type: Axiom
annotated source: chlorzoxazone
annotated property: database_cross_reference
annotated target: Reaxys:638882

phosphoethanolamine
type: Class
subclass of: organophosphorus compound

darunavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.
database_cross_reference: Beilstein:7960555
database_cross_reference: CAS:206361-99-1
database_cross_reference: DrugBank:DB01264
database_cross_reference: Drug_Central:4143
database_cross_reference: PMID:15771427
database_cross_reference: PMID:16480273
database_cross_reference: PMID:25017682
database_cross_reference: Reaxys:7960555
has_exact_synonym: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
has_exact_synonym: Darunavir
has_related_synonym: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
has_related_synonym: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate
has_related_synonym: (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
has_related_synonym: (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
has_related_synonym: N-((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide
has_related_synonym: TMC114
has_related_synonym: [(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester
has_related_synonym: darunavir
has_related_synonym: darunavirum
has_related_synonym: {(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester
id: CHEBI:367163

Beilstein
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: Beilstein:7960555

ChemIDplus
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: CAS:206361-99-1

DrugCentral
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: Drug_Central:4143

ChEMBL
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: PMID:15771427

ChEMBL
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: PMID:16480273

Europe PMC
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: PMID:25017682

Reaxys
type: Axiom
annotated source: darunavir
annotated property: database_cross_reference
annotated target: Reaxys:7960555

duloxetine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:8842375
database_cross_reference: CAS:116539-58-3
database_cross_reference: PMID:20825390
has_exact_synonym: N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine
has_related_synonym: N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
id: CHEBI:36796

Beilstein
type: Axiom
annotated source: duloxetine
annotated property: database_cross_reference
annotated target: Beilstein:8842375

ChemIDplus
type: Axiom
annotated source: duloxetine
annotated property: database_cross_reference
annotated target: CAS:116539-58-3

Europe PMC
type: Axiom
annotated source: duloxetine
annotated property: database_cross_reference
annotated target: PMID:20825390

nucleotide
type: Class
subclass of: organic molecule
subclass of: IMR_0001698
definition: A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.
database_cross_reference: A nucleotide consists of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Nucleotides can carry chemical energy (e.g. ATP), form coenzymes (e.g. CoA), be used as specific signaling molecules (e.g. cAMP) in the cell. Nucleotides are the subunits of the nucleic acids.
database_cross_reference: IMR:0001349

Axiom
annotated source: nucleotide
annotated property: database_cross_reference
annotated target: A nucleotide consists of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Nucleotides can carry chemical energy (e.g. ATP), form coenzymes (e.g. CoA), be used as specific signaling molecules (e.g. cAMP) in the cell. Nucleotides are the subunits of the nucleic acids.
database_cross_reference: ISBN:0815340729

EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
definition: Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16).
has_related_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor
has_related_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors
has_related_synonym: Aspergillus awamori acid protein phosphatase inhibitor
has_related_synonym: Aspergillus awamori acid protein phosphatase inhibitors
has_related_synonym: BCKDH phosphatase inhibitor
has_related_synonym: BCKDH phosphatase inhibitors
has_related_synonym: EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors
has_related_synonym: EC 3.1.3.16 inhibitor
has_related_synonym: EC 3.1.3.16 inhibitors
has_related_synonym: HMG-CoA reductase phosphatase inhibitor
has_related_synonym: HMG-CoA reductase phosphatase inhibitors
has_related_synonym: branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor
has_related_synonym: branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors
has_related_synonym: calcineurin inhibitor
has_related_synonym: calcineurin inhibitors
has_related_synonym: casein phosphatase inhibitor
has_related_synonym: casein phosphatase inhibitors
has_related_synonym: phosphatase 2A inhibitor
has_related_synonym: phosphatase 2A inhibitors
has_related_synonym: phosphatase 2B inhibitor
has_related_synonym: phosphatase 2B inhibitors
has_related_synonym: phosphatase C-II inhibitor
has_related_synonym: phosphatase C-II inhibitors
has_related_synonym: phosphatase H-II inhibitor
has_related_synonym: phosphatase H-II inhibitors
has_related_synonym: phosphatase I inhibitor
has_related_synonym: phosphatase I inhibitors
has_related_synonym: phosphatase IB inhibitor
has_related_synonym: phosphatase IB inhibitors
has_related_synonym: phosphatase II inhibitor
has_related_synonym: phosphatase II inhibitors
has_related_synonym: phosphatase III inhibitor
has_related_synonym: phosphatase III inhibitors
has_related_synonym: phosphatase IV inhibitor
has_related_synonym: phosphatase IV inhibitors
has_related_synonym: phosphatase SP inhibitor
has_related_synonym: phosphatase SP inhibitors
has_related_synonym: phosphoprotein phosphatase (EC 3.1.3.16) inhibitor
has_related_synonym: phosphoprotein phosphatase (EC 3.1.3.16) inhibitors
has_related_synonym: phosphoprotein phosphatase inhibitor
has_related_synonym: phosphoprotein phosphatase inhibitors
has_related_synonym: phosphoprotein phosphohydrolase inhibitor
has_related_synonym: phosphoprotein phosphohydrolase inhibitors
has_related_synonym: phosphopyruvate dehydrogenase phosphatase inhibitor
has_related_synonym: phosphopyruvate dehydrogenase phosphatase inhibitors
has_related_synonym: phosphospectrin phosphatase inhibitor
has_related_synonym: phosphospectrin phosphatase inhibitors
has_related_synonym: polycation modulated (PCM-) phosphatase inhibitor
has_related_synonym: polycation modulated (PCM-) phosphatase inhibitors
has_related_synonym: protein D phosphatase inhibitor
has_related_synonym: protein D phosphatase inhibitors
has_related_synonym: protein phosphatase inhibitor
has_related_synonym: protein phosphatase inhibitors
has_related_synonym: protein phosphatase-1 inhibitor
has_related_synonym: protein phosphatase-1 inhibitors
has_related_synonym: protein phosphatase-2A inhibitor
has_related_synonym: protein phosphatase-2A inhibitors
has_related_synonym: protein phosphatase-2B inhibitor
has_related_synonym: protein phosphatase-2B inhibitors
has_related_synonym: protein phosphatase-2C inhibitor
has_related_synonym: protein phosphatase-2C inhibitors
has_related_synonym: protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors
has_related_synonym: protein serine/threonine phosphatase inhibitor
has_related_synonym: protein serine/threonine phosphatase inhibitors
has_related_synonym: serine/threonine specific protein phosphatase inhibitor
has_related_synonym: serine/threonine specific protein phosphatase inhibitors
id: CHEBI:37153

clarithromycin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: protein synthesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.
database_cross_reference: Beilstein:3581974
database_cross_reference: CAS:81103-11-9
database_cross_reference: DrugBank:DB01211
database_cross_reference: Drug_Central:668
database_cross_reference: LINCS:LSM-5606
database_cross_reference: LIPID_MAPS_instance:LMPK04000014
database_cross_reference: PMID:16387493
database_cross_reference: Reaxys:3581974
has_exact_synonym: CLARITHROMYCIN
has_exact_synonym: Clarithromycin
has_exact_synonym: O(6)-methylerythromycin
has_related_synonym: 6-O-methylerythromycin
has_related_synonym: 6-O-methylerythromycin A
has_related_synonym: CLA
has_related_synonym: clarithromycin
has_related_synonym: clarithromycina
has_related_synonym: clarithromycine
has_related_synonym: clarithromycinum
id: CHEBI:3732

Beilstein
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: Beilstein:3581974

ChemIDplus
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: CAS:81103-11-9

DrugCentral
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: Drug_Central:668

LIPID MAPS
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMPK04000014

ChEMBL
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: PMID:16387493

Reaxys
type: Axiom
annotated source: clarithromycin
annotated property: database_cross_reference
annotated target: Reaxys:3581974

phosphatidylinositol bisphosphate
type: Class
subclass of: phosphatidylinositol phosphate

clofibrate
type: Class
subclass of: TXPO_1000442
subclass of: Restriction
  on property: has role
  some values from: antilipemic drug
subclass of: Restriction
  on property: has role
  some values from: anticholesteremic drug
definition: The ethyl ester of clofibric acid.
formula: C12H15ClO3
smiles: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
database_cross_reference: LINCS:LSM-2996
database_cross_reference: Open TG-Gates compound_id:00006
database_cross_reference: Wikipedia:Clofibrate
has_exact_synonym: ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

acid
type: Class
subclass of: chemical role
definition: An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).

sphingosine-1-phosphate
type: Class
subclass of: phosphosphingolipid
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003686
definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
description: Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems.
database_cross_reference: IMR:0100179
has_exact_synonym: S1P

Axiom
annotated source: sphingosine-1-phosphate
annotated property: description
annotated target: Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems.
database_cross_reference: PMID:15059942

fatty acyl-CoA
type: Class
subclass of: fatty acid derivative
definition: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any fatty acid.
formula: C22H35N7O17P3SR
database_cross_reference: PMID:11524729
database_cross_reference: PMID:20442897
database_cross_reference: PMID:2079609

clozapine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: adrenergic antagonist
subclass of: Restriction
  on property: has role
  some values from: histamine antagonist
subclass of: Restriction
  on property: has role
  some values from: serotonergic antagonist
subclass of: Restriction
  on property: has role
  some values from: dopaminergic antagonist
subclass of: Restriction
  on property: has role
  some values from: muscarinic antagonist
subclass of: Restriction
  on property: has role
  some values from: second generation antipsychotic
subclass of: Restriction
  on property: has role
  some values from: GABA antagonist
subclass of: Restriction
  on property: has role
  some values from: EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
database_cross_reference: Beilstein:0764984
database_cross_reference: CAS:5786-21-0
database_cross_reference: DrugBank:DB00363
database_cross_reference: Drug_Central:722
database_cross_reference: PMID:18690109
database_cross_reference: PMID:18766167
database_cross_reference: PMID:20825390
database_cross_reference: PMID:24219174
database_cross_reference: Reaxys:764984
has_exact_synonym: 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
has_exact_synonym: Clozapine
has_related_synonym: Clozapin
has_related_synonym: clozapina
has_related_synonym: clozapine
has_related_synonym: clozapinum
id: CHEBI:3766

Beilstein
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: Beilstein:0764984

ChemIDplus
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: CAS:5786-21-0

DrugCentral
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: Drug_Central:722

Europe PMC
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: PMID:18690109

Europe PMC
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: PMID:18766167

Europe PMC
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: PMID:20825390

Europe PMC
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: PMID:24219174

Reaxys
type: Axiom
annotated source: clozapine
annotated property: database_cross_reference
annotated target: Reaxys:764984

protease inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
definition: A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).
has_related_synonym: protease inhibitors
id: CHEBI:37670

protein kinase inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases.
has_related_synonym: protein kinase inhibitors
id: CHEBI:37699

EC 2.7.11.13 (protein kinase C) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
has_related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor
has_related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors
has_related_synonym: EC 2.7.11.13 (protein kinase C) inhibitors
has_related_synonym: EC 2.7.11.13 inhibitor
has_related_synonym: EC 2.7.11.13 inhibitors
has_related_synonym: PKC inhibitor
has_related_synonym: PKC inhibitors
has_related_synonym: PKCalpha inhibitor
has_related_synonym: PKCalpha inhibitors
has_related_synonym: PKCbeta inhibitor
has_related_synonym: PKCbeta inhibitors
has_related_synonym: PKCdelta inhibitor
has_related_synonym: PKCdelta inhibitors
has_related_synonym: PKCepsilon inhibitor
has_related_synonym: PKCepsilon inhibitors
has_related_synonym: PKCgamma inhibitor
has_related_synonym: PKCgamma inhibitors
has_related_synonym: PKCzeta inhibitor
has_related_synonym: PKCzeta inhibitors
has_related_synonym: PKN3 inhibitor
has_related_synonym: PKN3 inhibitors
has_related_synonym: Pkc1p inhibitor
has_related_synonym: Pkc1p inhibitors
has_related_synonym: STK24 inhibitor
has_related_synonym: STK24 inhibitors
has_related_synonym: cPKC inhibitor
has_related_synonym: cPKC inhibitors
has_related_synonym: cPKCalpha inhibitor
has_related_synonym: cPKCalpha inhibitors
has_related_synonym: cPKCbeta inhibitor
has_related_synonym: cPKCbeta inhibitors
has_related_synonym: cPKCgamma inhibitor
has_related_synonym: cPKCgamma inhibitors
has_related_synonym: calcium-dependent protein kinase C inhibitor
has_related_synonym: calcium-dependent protein kinase C inhibitors
has_related_synonym: calcium-independent protein kinase C inhibitor
has_related_synonym: calcium-independent protein kinase C inhibitors
has_related_synonym: calcium/phospholipid dependent protein kinase inhibitor
has_related_synonym: calcium/phospholipid dependent protein kinase inhibitors
has_related_synonym: nPKC inhibitor
has_related_synonym: nPKC inhibitors
has_related_synonym: nPKCdelta inhibitor
has_related_synonym: nPKCdelta inhibitors
has_related_synonym: nPKCepsilon inhibitor
has_related_synonym: nPKCepsilon inhibitors
has_related_synonym: nPKCeta inhibitor
has_related_synonym: nPKCeta inhibitors
has_related_synonym: nPKCtheta inhibitor
has_related_synonym: nPKCtheta inhibitors
has_related_synonym: protein kinase C (EC 2.7.11.13) inhibitor
has_related_synonym: protein kinase C (EC 2.7.11.13) inhibitors
has_related_synonym: protein kinase C inhibitor
has_related_synonym: protein kinase C inhibitors
has_related_synonym: protein kinase Cepsilon inhibitor
has_related_synonym: protein kinase Cepsilon inhibitors
id: CHEBI:37700

EC 3.1.1.8 (cholinesterase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
has_related_synonym: BChE inhibitor
has_related_synonym: BChE inhibitors
has_related_synonym: BtChoEase inhibitor
has_related_synonym: BtChoEase inhibitors
has_related_synonym: EC 3.1.1.8 (cholinesterase) inhibitors
has_related_synonym: EC 3.1.1.8 inhibitor
has_related_synonym: EC 3.1.1.8 inhibitors
has_related_synonym: anticholineesterase inhibitor
has_related_synonym: anticholineesterase inhibitors
has_related_synonym: anticholinesterase
has_related_synonym: anticholinesterases
has_related_synonym: benzoylcholinesterase inhibitor
has_related_synonym: benzoylcholinesterase inhibitors
has_related_synonym: butyrylcholine esterase inhibitor
has_related_synonym: butyrylcholine esterase inhibitors
has_related_synonym: butyrylcholinesterase inhibitor
has_related_synonym: butyrylcholinesterase inhibitors
has_related_synonym: choline esterase II (unspecific) inhibitor
has_related_synonym: choline esterase II (unspecific) inhibitors
has_related_synonym: choline esterase inhibitor
has_related_synonym: choline esterase inhibitors
has_related_synonym: cholinesterase (EC 3.1.1.8) inhibitor
has_related_synonym: cholinesterase (EC 3.1.1.8) inhibitors
has_related_synonym: cholinesterase inhibitor
has_related_synonym: non-specific cholinesterase inhibitor
has_related_synonym: non-specific cholinesterase inhibitors
has_related_synonym: propionylcholinesterase inhibitor
has_related_synonym: propionylcholinesterase inhibitors
has_related_synonym: pseudocholinesterase inhibitor
has_related_synonym: pseudocholinesterase inhibitors
id: CHEBI:37733

phosphoric ester
type: Class
subclass of: organic molecular entity

glycerophospholipid
type: Class
subclass of: phospholipid
subclass of: glycerolipid
definition: Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.
database_cross_reference: PMID:17393491
database_cross_reference: http://purl.obolibrary.org/obo/IMR_0001384
has_exact_synonym: phosphatide
has_exact_synonym: phosphoglyceride

Axiom
annotated source: glycerophospholipid
annotated property: definition
annotated target: Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.
definition source: CHEBI:37739

growth hormone
type: Class
subclass of: hormone
definition: A hormone that specifically regulates growth.
database_cross_reference: CAS:9002-72-6

adrenergic agonist
type: Class
subclass of: adrenergic agent
definition: An agent that selectively binds to and activates adrenergic receptors.
has_related_synonym: adrenergic agonists
has_related_synonym: adrenergic receptor agonist
has_related_synonym: adrenoceptor agonists
has_related_synonym: adrenomimetic
has_related_synonym: adrenomimetics
id: CHEBI:37886

adrenergic antagonist
type: Class
subclass of: adrenergic agent
definition: An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
has_related_synonym: adrenergic antagonists
has_related_synonym: adrenergic blockaders
has_related_synonym: adrenergic blocker
has_related_synonym: adrenergic blockers
has_related_synonym: adrenergic receptor blockaders
has_related_synonym: adrenoceptor antagonists
id: CHEBI:37887

alpha-adrenergic antagonist
type: Class
subclass of: adrenergic antagonist
subclass of: alpha-adrenergic drug
definition: An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
has_related_synonym: alpha-adrenergic antagonists
has_related_synonym: alpha-adrenergic blocker
has_related_synonym: alpha-adrenergic blockers
has_related_synonym: alpha-adrenergic receptor blockaders
has_related_synonym: alpha-adrenoceptor antagonists
id: CHEBI:37890

atazanavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
definition: A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).
database_cross_reference: CAS:198904-31-3
database_cross_reference: DrugBank:DB01072
database_cross_reference: Wikipedia:Atazanavir
has_exact_synonym: dimethyl (3S,8S,9S,12S)-9-benzyl-3,12-di-tert-butyl-8-hydroxy-4,11-dioxo-6-[4-(2-pyridyl)benzyl]-2,5,6,10,13-pentaazatetradecanedioate

histamine antagonist
type: Class
subclass of: histaminergic drug
subclass of: antagonist
definition: Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
database_cross_reference: PMID:22035879
has_related_synonym: antihistamine
has_related_synonym: antihistamines
has_related_synonym: antihistaminico
has_related_synonym: antihistaminics
has_related_synonym: histamine receptor blocker
has_related_synonym: histamine receptor blockers
id: CHEBI:37956

Europe PMC
type: Axiom
annotated source: histamine antagonist
annotated property: database_cross_reference
annotated target: PMID:22035879

histaminergic drug
type: Class
subclass of: neurotransmitter agent
definition: Drugs used for their actions on histaminergic systems.
has_related_synonym: histamine agents
has_related_synonym: histamine drugs
has_related_synonym: histaminergic agent
has_related_synonym: histaminergic agents
has_related_synonym: histaminergic drugs
id: CHEBI:37957

adrenergic agent
type: Class
subclass of: neurotransmitter agent
definition: Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
has_related_synonym: adrenergic agents
has_related_synonym: adrenergic drug
has_related_synonym: adrenergic drugs
has_related_synonym: adrenergic neuron agents
has_related_synonym: adrenergics
id: CHEBI:37962

antimalarial
type: Class
subclass of: antiplasmodial drug
definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
has_related_synonym: antimalarials
id: CHEBI:38068

anti-arrhythmia drug
type: Class
subclass of: cardiovascular drug
definition: A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
has_related_synonym: antiarrhythmic agent
id: CHEBI:38070

cardiotonic drug
type: Class
subclass of: cardiovascular drug
definition: A drug that has a strengthening effect on the heart or that can increase cardiac output.

iron chelator
type: Class
subclass of: chelator
has_related_synonym: iron chelating agents
has_related_synonym: iron chelators
id: CHEBI:38157

chelator
type: Class
subclass of: chemical role
subclass of: ligand
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
definition: A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
has_related_synonym: Chelating agent
has_related_synonym: Metal chelator
has_related_synonym: chelating agents
has_related_synonym: chelators
has_related_synonym: complexon
id: CHEBI:38161

Methapyrilene hydrochloride
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: sedative
subclass of: Restriction
  on property: has role
  some values from: anti-allergic agent
definition: A hydrochloride that is the monohydrochloride salt of methapyrilene.
formula: C14H19N3S.ClH
formula: C14H20ClN3S
smiles: Cl.CN(C)CCN(Cc1cccs1)c1ccccn1
database_cross_reference: CAS:135-23-9
database_cross_reference: DrugBank:DB04819
has_exact_synonym: N,N-dimethyl-N'-pyridin-2-yl-N'-[(thiophen-2-yl)methyl]ethane-1,2-diamine hydrochloride

Monuron
type: Class
subclass of: organic molecular entity
definition: A member of the class of phhenylureas that is urea in which one of the nitrogens is substituted by a p-chlorophenyl group while the other is substituted by two methyl groups.
formula: C9H11ClN2O
smiles: CN(C)C(=O)Nc1ccc(Cl)cc1
database_cross_reference: CAS:150-68-5
has_exact_synonym: 3-(4-chlorophenyl)-1,1-dimethylurea

calcium channel blocker
type: Class
subclass of: calcium channel modulator
definition: One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
has_related_synonym: calcium channel antagonist
has_related_synonym: calcium channel antagonists
has_related_synonym: calcium channel blockers
id: CHEBI:38215

fumonisin B1
type: Class
subclass of: organic molecular entity
definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
formula: C34H59NO15
database_cross_reference: CAS:116355-83-0
has_exact_synonym: (2R,2'R)-2,2'-{[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-11,16,18-trihydroxy-5,9-dimethylicosane-6,7-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}dibutanedioic acid

DNA polymerase inhibitor
type: Class
subclass of: EC 2.7.7.* (nucleotidyltransferase) inhibitor
definition: Any inhibitor of a DNA polymerase.
id: CHEBI:38234

cholinergic drug
type: Class
subclass of: neurotransmitter agent
definition: Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
has_related_synonym: cholinergic agent
has_related_synonym: cholinergic drugs
has_related_synonym: cholinomimetic
id: CHEBI:38323

acetylcholinesterase inhibitor role
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
has_exact_synonym: EC 3.1.1.7 (acetylcholinesterase) inhibitor role

electron-transport chain inhibitor
type: Class
subclass of: pathway inhibitor
definition: A role played by the entity that inhibits the electron-transport chain
id: CHEBI:38496

respiratory-chain inhibitor
type: Class
subclass of: electron-transport chain inhibitor
definition: A role played by the entity that inhibits the respiratory-chain.
id: CHEBI:38497

EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
type: Class
subclass of: respiratory-chain inhibitor
subclass of: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
definition: A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H(+)-translocating), EC 1.6.5.3.
has_related_synonym: DPNH-coenzyme Q reductase inhibitor
has_related_synonym: DPNH-ubiquinone reductase inhibitor
has_related_synonym: EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor
has_related_synonym: EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors
has_related_synonym: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors
has_related_synonym: EC 1.6.5.3 inhibitor
has_related_synonym: EC 1.6.5.3 inhibitors
has_related_synonym: NADH coenzyme Q1 reductase inhibitor
has_related_synonym: NADH coenzyme Q1 reductase inhibitors
has_related_synonym: NADH dehydrogenase (ubiquinone) inhibitor
has_related_synonym: NADH dehydrogenase (ubiquinone) inhibitors
has_related_synonym: NADH-CoQ oxidoreductase inhibitor
has_related_synonym: NADH-CoQ oxidoreductase inhibitors
has_related_synonym: NADH-CoQ reductase inhibitor
has_related_synonym: NADH-CoQ reductase inhibitors
has_related_synonym: NADH-Q6 oxidoreductase inhibitor
has_related_synonym: NADH-coenzyme Q oxidoreductase inhibitors
has_related_synonym: NADH-coenzyme Q reductase inhibitor
has_related_synonym: NADH-coenzyme Q reductase inhibitors
has_related_synonym: NADH-ubiquinone oxidoreductase inhibitor
has_related_synonym: NADH-ubiquinone oxidoreductase inhibitors
has_related_synonym: NADH-ubiquinone reductase inhibitor
has_related_synonym: NADH-ubiquinone reductase inhibitors
has_related_synonym: NADH-ubiquinone-1 reductase inhibitor
has_related_synonym: NADH-ubiquinone-1 reductase inhibitors
has_related_synonym: NADH2 dehydrogenase (ubiquinone) inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase complex inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase inhibitors
has_related_synonym: NADH:ubiquinone reductase (H(+)-translocating) inhibitor
has_related_synonym: NADH:ubiquinone reductase (H(+)-translocating) inhibitors
has_related_synonym: NADH:ubiquinone reductase (H+-translocating) inhibitor
has_related_synonym: NADH:ubiquinone reductase inhibitor
has_related_synonym: coenzyme Q reductase
has_related_synonym: complex 1 dehydrogenase inhibitor
has_related_synonym: complex I (NADH:Q1 oxidoreductase) inhibitors
has_related_synonym: complex I (electron transport chain) inhibitors
has_related_synonym: complex I (mitochondrial electron transport) inhibitors
has_related_synonym: dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
has_related_synonym: electron transfer complex I inhibitor
has_related_synonym: electron transfer complex I inhibitors
has_related_synonym: mitochondrial electron transport complex 1 inhibitor
has_related_synonym: mitochondrial electron transport complex I inhibitor
has_related_synonym: mitochondrial electron transport complex I inhibitors
has_related_synonym: reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
has_related_synonym: reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors
has_related_synonym: type 1 dehydrogenase inhibitor
has_related_synonym: type 1 dehydrogenase inhibitors
has_related_synonym: ubiquinone reductase inhibitor
has_related_synonym: ubiquinone reductase inhibitors
id: CHEBI:38503

membrane transport modulator
type: Class
subclass of: biophysical role
subclass of: TXPO_0003230
definition: Any agent that affects the transport of molecular entities across a biological membrane.
has_related_synonym: membrane transport modulators
id: CHEBI:38632

sodium channel blocker
type: Class
subclass of: sodium channel modulator
definition: An agent that inhibits sodium influx through cell membranes.
has_related_synonym: Na channel blocker
has_related_synonym: sodium channel blockers
id: CHEBI:38633

tyrosine kinase inhibitor
type: Class
subclass of: protein kinase inhibitor
definition: Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
has_related_synonym: TKI inhibitor
has_related_synonym: TKI inhibitors
has_related_synonym: protein tyrosine kinase inhibitor
has_related_synonym: protein tyrosine kinase inhibitors
has_related_synonym: tyrosine kinase inhibitors
has_related_synonym: tyrphostin
has_related_synonym: tyrphostins
id: CHEBI:38637

calcium channel agonist
type: Class
subclass of: calcium channel modulator
definition: Agents that increase calcium influx into calcium channels of excitable tissues.
has_related_synonym: calcium channel activator

calcium channel modulator
type: Class
subclass of: membrane transport modulator
definition: A membrane transport modulator that is able to regulate intracellular calcium levels.
has_related_synonym: calcium channel modulators
id: CHEBI:38808

ryanodine receptor modulator
type: Class
subclass of: calcium channel modulator
has_related_synonym: RyR modulator

sunitinib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: angiogenesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: immunomodulator
subclass of: Restriction
  on property: has role
  some values from: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: neuroprotective agent
subclass of: Restriction
  on property: has role
  some values from: vascular endothelial growth factor receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:557795-19-4
database_cross_reference: DrugBank:DB01268
database_cross_reference: Drug_Central:2544
database_cross_reference: PMID:12531805
database_cross_reference: PMID:16845442
database_cross_reference: PMID:16916320
database_cross_reference: PMID:17327610
database_cross_reference: PMID:17962201
database_cross_reference: PMID:18971320
database_cross_reference: PMID:19830602
database_cross_reference: PMID:20406969
database_cross_reference: PMID:21792888
database_cross_reference: PMID:24188025
database_cross_reference: PMID:24393200
database_cross_reference: PMID:24402960
database_cross_reference: PMID:24403097
database_cross_reference: PMID:24521256
has_exact_synonym: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
has_exact_synonym: Sunitinib
has_related_synonym: SU-11248
has_related_synonym: Sutent
has_related_synonym: sunitinib
has_related_synonym: sunitinibum
id: CHEBI:38940

ChemIDplus
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: CAS:557795-19-4

DrugCentral
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: Drug_Central:2544

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:12531805

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:16845442

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:16916320

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:17327610

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:17962201

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:18971320

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:19830602

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:20406969

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:21792888

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:24188025

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:24393200

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:24402960

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:24403097

Europe PMC
type: Axiom
annotated source: sunitinib
annotated property: database_cross_reference
annotated target: PMID:24521256

sodium channel modulator
type: Class
subclass of: membrane transport modulator
has_related_synonym: sodium channel modulators
id: CHEBI:39000

high-density lipoprotein
type: Class
subclass of: lipoprotein
definition: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. They are synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport).
has_related_synonym: HDL

very-low-density lipoprotein
type: Class
subclass of: lipoprotein
definition: A class of lipoproteins of large size (30-80 nm), very low density (0.93-1.006 g/ml) particles with a core composed mainly of triglycerides and a surface monolayer of phospholipids and cholesterol into which are imbedded the apolipoproteins B, E, and C. VLDL facilitate the transport of endogenously made triglycerides to extrahepatic tissues.
has_related_synonym: VLDL
has_related_synonym: very-low-density lipoproteins

pyrethrins
type: Class
subclass of: organic molecular entity
definition: The active insecticidal constituents of Chrysanthemum cinerariifolium flowers.
database_cross_reference: CAS:8003-34-7

calcium cation
type: Class
subclass of: calcium ion

calcium ion
type: Class
subclass of: TXPO_0000052
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002401
definition: A calcium cation that has formula Ca.
has_exact_synonym: Ca(2+)
has_exact_synonym: Ca++
has_exact_synonym: Ca2+
has_exact_synonym: calcium(2+)

atorvastatin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.
database_cross_reference: Beilstein:8373630
database_cross_reference: CAS:134523-00-5
database_cross_reference: DrugBank:DB01076
database_cross_reference: Drug_Central:257
database_cross_reference: LINCS:LSM-5771
database_cross_reference: PMID:11693468
database_cross_reference: PMID:15012735
database_cross_reference: PMID:18720283
database_cross_reference: Reaxys:8373630
has_exact_synonym: (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
has_exact_synonym: Atorvastatin
has_related_synonym: (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
has_related_synonym: 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
has_related_synonym: Atorlip
has_related_synonym: atorvastatin
has_related_synonym: atorvastatina
has_related_synonym: atorvastatine
has_related_synonym: atorvastatinum
id: CHEBI:39548

Beilstein
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: Beilstein:8373630

ChemIDplus
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: CAS:134523-00-5

DrugCentral
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: Drug_Central:257

Europe PMC
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: PMID:11693468

Europe PMC
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: PMID:15012735

Europe PMC
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: PMID:18720283

Reaxys
type: Axiom
annotated source: atorvastatin
annotated property: database_cross_reference
annotated target: Reaxys:8373630

diflunisal
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
database_cross_reference: CAS:22494-42-4
database_cross_reference: DrugBank:DB00861
database_cross_reference: Drug_Central:880
database_cross_reference: LINCS:LSM-2490
database_cross_reference: PMID:23144359
database_cross_reference: PMID:23416065
database_cross_reference: PMID:28166217
database_cross_reference: Reaxys:2654431
has_exact_synonym: 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
has_exact_synonym: Diflunisal
has_related_synonym: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid
has_related_synonym: 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid
has_related_synonym: 5-(2,4-difluorophenyl)salicylic acid
has_related_synonym: Dolobid
id: CHEBI:39669

ChemIDplus
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: CAS:22494-42-4

NIST Chemistry WebBook
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: CAS:22494-42-4

DrugCentral
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: Drug_Central:880

Europe PMC
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: PMID:23144359

Europe PMC
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: PMID:23416065

Europe PMC
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: PMID:28166217

Reaxys
type: Axiom
annotated source: diflunisal
annotated property: database_cross_reference
annotated target: Reaxys:2654431

valproic acid
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: psychotropic drug
subclass of: Restriction
  on property: has role
  some values from: antimanic drug
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has role
  some values from: teratogenic agent
subclass of: Restriction
  on property: has role
  some values from: GABA agent
subclass of: Restriction
  on property: has role
  some values from: EC 3.5.1.98 (histone deacetylase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: neuroprotective agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
formula: C8H16O2
smiles: CCCC(CCC)C(O)=O
database_cross_reference: Beilstein:1750447
database_cross_reference: CAS:99-66-1
database_cross_reference: DrugBank:DB00313
database_cross_reference: Drug_Central:2803
database_cross_reference: LINCS:LSM-4620
database_cross_reference: LIPID_MAPS_instance:LMFA01020291
database_cross_reference: PMID:11716839
database_cross_reference: PMID:12475192
database_cross_reference: PMID:15124690
database_cross_reference: PMID:15560954
database_cross_reference: PMID:15578701
database_cross_reference: PMID:16496131
database_cross_reference: PMID:16621443
database_cross_reference: PMID:16759735
database_cross_reference: PMID:17156483
database_cross_reference: PMID:17273758
database_cross_reference: PMID:19280426
database_cross_reference: PMID:19318486
database_cross_reference: PMID:23792104
database_cross_reference: PMID:23810771
database_cross_reference: PMID:23949302
database_cross_reference: PMID:24135375
database_cross_reference: PMID:24200999
database_cross_reference: PMID:24348849
database_cross_reference: PMID:8558327
database_cross_reference: PMID:8681902
database_cross_reference: Reaxys:1750447
database_cross_reference: Wikipedia:Valproic_Acid
has_exact_synonym: 2-propylpentanoic acid
has_exact_synonym: VALPROIC ACID
has_related_synonym: 2-PROPYL-PENTANOIC ACID
has_related_synonym: 2-n-propyl-n-valeric acid
has_related_synonym: 2-propylpentanoic acid
has_related_synonym: 2-propylvaleric acid
has_related_synonym: 4-heptanecarboxylic acid
has_related_synonym: DPA
has_related_synonym: Depakene
has_related_synonym: Di-n-propylessigsaeure
has_related_synonym: VPA
has_related_synonym: Valproinsaeure
has_related_synonym: acide valproique
has_related_synonym: acido valproico
has_related_synonym: acidum valproicum
has_related_synonym: di-n-propylacetic acid
has_related_synonym: dipropylacetic acid
has_related_synonym: n-DPA
has_related_synonym: valproic acid
id: CHEBI:39867

ChemIDplus
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: Beilstein:1750447

ChemIDplus
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: CAS:99-66-1

NIST Chemistry WebBook
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: CAS:99-66-1

DrugCentral
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: Drug_Central:2803

LIPID MAPS
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMFA01020291

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:11716839

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:12475192

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:15124690

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:15560954

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:15578701

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:16496131

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:16621443

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:16759735

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:17156483

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:17273758

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:19280426

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:19318486

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:23792104

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:23810771

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:23949302

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:24135375

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:24200999

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:24348849

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:8558327

Europe PMC
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: PMID:8681902

Reaxys
type: Axiom
annotated source: valproic acid
annotated property: database_cross_reference
annotated target: Reaxys:1750447

allopurinol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: EC 1.17.3.2 (xanthine oxidase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: gout suppressant
subclass of: Restriction
  on property: has role
  some values from: radical scavenger
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
database_cross_reference: Beilstein:608611
database_cross_reference: CAS:315-30-0
database_cross_reference: DrugBank:DB00437
database_cross_reference: Drug_Central:124
database_cross_reference: LINCS:LSM-5919
database_cross_reference: PMID:11333159
database_cross_reference: PMID:16650385
database_cross_reference: PMID:24395556
database_cross_reference: PMID:24590210
database_cross_reference: PMID:24591375
database_cross_reference: PMID:7602118
database_cross_reference: Reaxys:608611
has_exact_synonym: 1H-pyrazolo[3,4-d]pyrimidin-4-ol
has_exact_synonym: Allopurinol
has_related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one
has_related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one
has_related_synonym: 1H-Pyrazolo(3,4-d)pyrimidin-4-ol
has_related_synonym: 4'-Hydroxypyrazolol(3,4-d)pyrimidine
has_related_synonym: 4-HPP
has_related_synonym: 4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine
has_related_synonym: 4-Hydroxy-3,4-pyrazolopyrimidine
has_related_synonym: 4-Hydroxypyrazolo(3,4-d)pyrimidine
has_related_synonym: 4-Hydroxypyrazolopyrimidine
has_related_synonym: 4-Hydroxypyrazolyl(3,4-d)pyrimidine
has_related_synonym: 4H-Pyrazolo(3,4-d)pyrimidin-4-one
has_related_synonym: AL-100
has_related_synonym: Allopurinolum
has_related_synonym: Alopurinol
has_related_synonym: Zyloprim (TN)
id: CHEBI:40279

Beilstein
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: Beilstein:608611

ChemIDplus
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: CAS:315-30-0

NIST Chemistry WebBook
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: CAS:315-30-0

DrugCentral
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: Drug_Central:124

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:11333159

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:16650385

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:24395556

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:24590210

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:24591375

Europe PMC
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: PMID:7602118

Reaxys
type: Axiom
annotated source: allopurinol
annotated property: database_cross_reference
annotated target: Reaxys:608611

cyclosporin A
type: Class
subclass of: organic molecular entity
definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
formula: C62H111N11O12
database_cross_reference: DrugBank:DB00091
database_cross_reference: LINCS:LSM-1703
has_exact_synonym: 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

tamoxifen
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: EC 2.7.11.13 (protein kinase C) inhibitor
subclass of: Restriction
  on property: has role
  some values from: angiogenesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: bone density conservation agent
subclass of: Restriction
  on property: has role
  some values from: estrogen receptor modulator
subclass of: Restriction
  on property: has role
  some values from: estrogen receptor antagonist
subclass of: Restriction
  on property: has role
  some values from: estrogen antagonist
subclass of: Restriction
  on property: has role
  some values from: EC 1.2.3.1 (aldehyde oxidase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. (by Wikipedia)
formula: C26H29NO
smiles: CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
database_cross_reference: Beilstein:2062020
database_cross_reference: CAS:10540-29-1
database_cross_reference: DrugBank:DB00675
database_cross_reference: Drug_Central:2561
database_cross_reference: PMID:12612646
database_cross_reference: PMID:14681337
database_cross_reference: PMID:14709804
database_cross_reference: PMID:18348622
database_cross_reference: PMID:7688593
has_exact_synonym: 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
has_exact_synonym: Tamoxifen
has_related_synonym: (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
has_related_synonym: (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
has_related_synonym: 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
has_related_synonym: 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
has_related_synonym: Apo-Tamox
has_related_synonym: Crisafeno
has_related_synonym: Diemon
has_related_synonym: tamoxifen
has_related_synonym: tamoxifene
has_related_synonym: tamoxifeno
has_related_synonym: tamoxifenum
has_related_synonym: trans-Tamoxifen
id: CHEBI:41774

Beilstein
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: Beilstein:2062020

ChemIDplus
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: CAS:10540-29-1

DrugCentral
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: Drug_Central:2561

Europe PMC
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: PMID:14681337

Europe PMC
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: PMID:14709804

Europe PMC
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: PMID:18348622

Europe PMC
type: Axiom
annotated source: tamoxifen
annotated property: database_cross_reference
annotated target: PMID:7688593

abacavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
database_cross_reference: Beilstein:7493116
database_cross_reference: CAS:136470-78-5
database_cross_reference: DrugBank:DB01048
database_cross_reference: Drug_Central:34
database_cross_reference: PMID:11678376
database_cross_reference: PMID:11806176
database_cross_reference: PMID:12781181
database_cross_reference: PMID:15887959
database_cross_reference: PMID:16458506
database_cross_reference: PMID:16539393
database_cross_reference: PMID:16759112
database_cross_reference: PMID:17172311
database_cross_reference: PMID:17870541
database_cross_reference: PMID:18029175
database_cross_reference: PMID:18549801
database_cross_reference: PMID:24751900
database_cross_reference: PMID:25017682
database_cross_reference: PMID:25674793
database_cross_reference: PMID:26024233
database_cross_reference: Reaxys:7493116
has_exact_synonym: Abacavir
has_exact_synonym: {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
has_related_synonym: ABC
has_related_synonym: abacavir
has_related_synonym: {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
id: CHEBI:421707

Beilstein
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: Beilstein:7493116

ChemIDplus
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: CAS:136470-78-5

DrugCentral
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: Drug_Central:34

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:11678376

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:11806176

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:12781181

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:15887959

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:16458506

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:16539393

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:16759112

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:17172311

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:17870541

ChEMBL
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:18029175

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:18549801

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:24751900

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:25017682

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:25674793

Europe PMC
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: PMID:26024233

Reaxys
type: Axiom
annotated source: abacavir
annotated property: database_cross_reference
annotated target: Reaxys:7493116

erythromycin A
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
definition: An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.
formula: C37H67NO13
database_cross_reference: DrugBank:DB00199
database_cross_reference: Wikipedia:Erythromycin

dacarbazine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: alkylating agent
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: prodrug
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
database_cross_reference: Beilstein:521487
database_cross_reference: CAS:4342-03-4
database_cross_reference: DrugBank:DB00851
database_cross_reference: Drug_Central:773
database_cross_reference: PMID:10751609
database_cross_reference: PMID:11318431
database_cross_reference: PMID:12195827
database_cross_reference: PMID:15010317
database_cross_reference: PMID:20082117
database_cross_reference: PMID:21471822
database_cross_reference: PMID:21654834
database_cross_reference: PMID:23029050
database_cross_reference: PMID:23318786
database_cross_reference: PMID:26940170
database_cross_reference: PMID:28096700
database_cross_reference: PMID:28250333
database_cross_reference: PMID:28387914
database_cross_reference: PMID:28419676
database_cross_reference: PMID:29076951
database_cross_reference: PMID:29184162
database_cross_reference: PMID:29287706
database_cross_reference: PMID:29296081
database_cross_reference: PMID:29305638
database_cross_reference: PMID:29344241
database_cross_reference: Reaxys:521487
has_exact_synonym: 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
has_related_synonym: 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide
has_related_synonym: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide
has_related_synonym: 4-(dimethyltriazeno)imidazole-5-carboxamide
has_related_synonym: 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
has_related_synonym: 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide
has_related_synonym: 5-(3,3-dimethyltriazeno)imidazole-4-carboxamide
has_related_synonym: 5-(dimethyltriazeno)imidazole-4-carboxamide
has_related_synonym: DIC
has_related_synonym: DTIC
has_related_synonym: Di-me-triazenoimidazolecarboxamide
has_related_synonym: Dtic-Dome (TN)
has_related_synonym: HSDB 3219
has_related_synonym: ICDMT
has_related_synonym: Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-
has_related_synonym: NCI-C04717
has_related_synonym: NSC 45388
has_related_synonym: NSC-45388
has_related_synonym: dacarbazina
has_related_synonym: dacarbazine
has_related_synonym: dacarbazinum
has_related_synonym: deticene
id: CHEBI:4305

Beilstein
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: Beilstein:521487

ChemIDplus
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annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: CAS:4342-03-4

NIST Chemistry WebBook
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: CAS:4342-03-4

DrugCentral
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: Drug_Central:773

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:10751609

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:11318431

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:12195827

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:15010317

Europe PMC
type: Axiom
annotated source: dacarbazine
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annotated target: PMID:20082117

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:21471822

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:21654834

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:23029050

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:23318786

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:26940170

Europe PMC
type: Axiom
annotated source: dacarbazine
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annotated target: PMID:28096700

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:28250333

Europe PMC
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annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:28387914

Europe PMC
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annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:28419676

Europe PMC
type: Axiom
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Europe PMC
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annotated source: dacarbazine
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annotated target: PMID:29184162

Europe PMC
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annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:29287706

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:29296081

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:29305638

Europe PMC
type: Axiom
annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: PMID:29344241

Reaxys
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annotated source: dacarbazine
annotated property: database_cross_reference
annotated target: Reaxys:521487

danazol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anti-estrogen
subclass of: Restriction
  on property: has role
  some values from: estrogen antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:4851114
database_cross_reference: CAS:17230-88-5
database_cross_reference: DrugBank:DB01406
database_cross_reference: Drug_Central:779
database_cross_reference: PMID:17929794
database_cross_reference: PMID:18834112
has_exact_synonym: [1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
has_related_synonym: Cyclomen
has_related_synonym: Danocrine
has_related_synonym: danazol
has_related_synonym: danazolum
id: CHEBI:4315

Beilstein
type: Axiom
annotated source: danazol
annotated property: database_cross_reference
annotated target: Beilstein:4851114

ChemIDplus
type: Axiom
annotated source: danazol
annotated property: database_cross_reference
annotated target: CAS:17230-88-5

DrugCentral
type: Axiom
annotated source: danazol
annotated property: database_cross_reference
annotated target: Drug_Central:779

ChEMBL
type: Axiom
annotated source: danazol
annotated property: database_cross_reference
annotated target: PMID:17929794

ChEMBL
type: Axiom
annotated source: danazol
annotated property: database_cross_reference
annotated target: PMID:18834112

dantrolene
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: muscle relaxant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
database_cross_reference: Beilstein:705189
database_cross_reference: CAS:7261-97-4
database_cross_reference: DrugBank:DB01219
database_cross_reference: LINCS:LSM-3823
has_exact_synonym: 1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
has_exact_synonym: Dantrolene
has_related_synonym: dantrolene
has_related_synonym: dantroleno
has_related_synonym: dantrolenum
id: CHEBI:4317

Beilstein
type: Axiom
annotated source: dantrolene
annotated property: database_cross_reference
annotated target: Beilstein:705189

ChemIDplus
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annotated source: dantrolene
annotated property: database_cross_reference
annotated target: CAS:7261-97-4

indinavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
database_cross_reference: CAS:150378-17-9
database_cross_reference: DrugBank:DB00224
database_cross_reference: Drug_Central:1437
database_cross_reference: LINCS:LSM-5471
has_exact_synonym: (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
has_exact_synonym: 2-benzyl-5-[(2S)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethyl)piperazin-1-yl]-2,3,5-trideoxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-D-erythro-pentonamide
has_exact_synonym: Indinavir
has_related_synonym: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-Pentonamide
id: CHEBI:44032

ChemIDplus
type: Axiom
annotated source: indinavir
annotated property: database_cross_reference
annotated target: CAS:150378-17-9

DrugCentral
type: Axiom
annotated source: indinavir
annotated property: database_cross_reference
annotated target: Drug_Central:1437

methotrexate
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: immunosuppressive agent
subclass of: Restriction
  on property: has role
  some values from: antirheumatic drug
subclass of: Restriction
  on property: has role
  some values from: dermatologic drug
subclass of: Restriction
  on property: has role
  some values from: EC 1.5.1.3 (dihydrofolate reductase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: abortifacient
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:70669
database_cross_reference: CAS:59-05-2
database_cross_reference: DrugBank:DB00563
database_cross_reference: Drug_Central:1751
database_cross_reference: LINCS:LSM-5690
has_exact_synonym: METHOTREXATE
has_exact_synonym: Methotrexate
has_exact_synonym: N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
has_related_synonym: 4-amino-10-methylfolic acid
has_related_synonym: 4-amino-N(10)-methylpteroylglutamic acid
has_related_synonym: Emtexate
has_related_synonym: Ledertrexate
has_related_synonym: MTX
has_related_synonym: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
has_related_synonym: Rheumatrex
has_related_synonym: Trexall
has_related_synonym: methotrexate
has_related_synonym: methotrexatum
has_related_synonym: metotrexato
id: CHEBI:44185

Beilstein
type: Axiom
annotated source: methotrexate
annotated property: database_cross_reference
annotated target: Beilstein:70669

ChemIDplus
type: Axiom
annotated source: methotrexate
annotated property: database_cross_reference
annotated target: CAS:59-05-2

NIST Chemistry WebBook
type: Axiom
annotated source: methotrexate
annotated property: database_cross_reference
annotated target: CAS:59-05-2

DrugCentral
type: Axiom
annotated source: methotrexate
annotated property: database_cross_reference
annotated target: Drug_Central:1751

dermatan
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A mucopolysaccharide consisting of repeating beta-(1->4)-linked L-iduronyl-(beta1->3)-N-acetyl-D-galactosamine units.
has_exact_synonym: Dermatan
has_related_synonym: Dermatan L-iduronate
id: CHEBI:4439

hydroxyurea
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: radical scavenger
subclass of: Restriction
  on property: has role
  some values from: immunomodulator
subclass of: Restriction
  on property: has role
  some values from: genotoxin
subclass of: Restriction
  on property: has role
  some values from: teratogenic agent
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: antimitotic
subclass of: Restriction
  on property: has role
  some values from: EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
database_cross_reference: Beilstein:1741548
database_cross_reference: CAS:127-07-1
database_cross_reference: DrugBank:DB01005
database_cross_reference: Drug_Central:1399
database_cross_reference: Gmelin:130423
database_cross_reference: PMID:11285159
database_cross_reference: PMID:11298103
database_cross_reference: PMID:11364534
database_cross_reference: PMID:11365149
database_cross_reference: PMID:11391710
database_cross_reference: PMID:12107454
database_cross_reference: PMID:14988684
database_cross_reference: PMID:15772364
database_cross_reference: PMID:15994344
database_cross_reference: PMID:16356682
database_cross_reference: PMID:22983419
database_cross_reference: PMID:23318979
database_cross_reference: PMID:23643402
database_cross_reference: PMID:23696560
database_cross_reference: PMID:9271088
database_cross_reference: Reaxys:1741548
has_exact_synonym: Hydroxyurea
has_exact_synonym: N-hydroxyurea
has_exact_synonym: hydroxyurea
has_related_synonym: Hydroxycarbamid
has_related_synonym: Hydroxycarbamide
has_related_synonym: Hydroxyharnstoff
has_related_synonym: N-HYDROXYUREA
has_related_synonym: N-carbamoylhydroxylamine
has_related_synonym: carbamohydroxamic acid
has_related_synonym: carbamohydroximic acid
has_related_synonym: carbamoyl oxime
has_related_synonym: carbamyl hydroxamate
has_related_synonym: hidroxicarbamida
has_related_synonym: hydrea
has_related_synonym: hydroxycarbamide
has_related_synonym: hydroxycarbamidum
has_related_synonym: oxyurea
id: CHEBI:44423

ChemIDplus
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: Beilstein:1741548

ChemIDplus
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: CAS:127-07-1

DrugCentral
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: Drug_Central:1399

Gmelin
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: Gmelin:130423

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:11285159

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:11298103

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:11364534

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:11365149

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:11391710

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:12107454

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:14988684

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:15772364

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:15994344

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:16356682

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:22983419

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:23318979

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:23643402

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:23696560

Europe PMC
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: PMID:9271088

Reaxys
type: Axiom
annotated source: hydroxyurea
annotated property: database_cross_reference
annotated target: Reaxys:1741548

nimesulide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 2 inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
formula: C13H12N2O5S
smiles: CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
database_cross_reference: Beilstein:2421175
database_cross_reference: CAS:51803-78-2
database_cross_reference: DrugBank:DB04743
database_cross_reference: Drug_Central:1935
database_cross_reference: LINCS:LSM-3718
database_cross_reference: PMID:18426087
database_cross_reference: Reaxys:2421175
has_exact_synonym: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
has_exact_synonym: Nimesulide
has_related_synonym: 4'-nitro-2'-phenoxymethanesulfonanilide
has_related_synonym: 4-NITRO-2-PHENOXYMETHANESULFONANILIDE
id: CHEBI:44445

Beilstein
type: Axiom
annotated source: nimesulide
annotated property: database_cross_reference
annotated target: Beilstein:2421175

ChemIDplus
type: Axiom
annotated source: nimesulide
annotated property: database_cross_reference
annotated target: CAS:51803-78-2

DrugCentral
type: Axiom
annotated source: nimesulide
annotated property: database_cross_reference
annotated target: Drug_Central:1935

Europe PMC
type: Axiom
annotated source: nimesulide
annotated property: database_cross_reference
annotated target: PMID:18426087

Reaxys
type: Axiom
annotated source: nimesulide
annotated property: database_cross_reference
annotated target: Reaxys:2421175

rifapentine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antitubercular agent
subclass of: Restriction
  on property: has role
  some values from: leprostatic drug
database_cross_reference: CAS:61379-65-5
database_cross_reference: DrugBank:DB01201
has_exact_synonym: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate
has_exact_synonym: Rifapentine
has_related_synonym: 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
has_related_synonym: Cyclopentylrifampicin
has_related_synonym: Priftin (TN)
id: CHEBI:45304

ChemIDplus
type: Axiom
annotated source: rifapentine
annotated property: database_cross_reference
annotated target: CAS:61379-65-5

ritonavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
database_cross_reference: CAS:155213-67-5
database_cross_reference: Drug_Central:2391
database_cross_reference: LINCS:LSM-5623
database_cross_reference: PMID:11363086
database_cross_reference: PMID:11363184
database_cross_reference: PMID:11363300
database_cross_reference: PMID:11363329
database_cross_reference: PMID:11363397
database_cross_reference: PMID:11363517
database_cross_reference: PMID:11996889
database_cross_reference: PMID:24202050
database_cross_reference: PMID:8568292
database_cross_reference: PMID:9140265
database_cross_reference: PMID:9278209
database_cross_reference: PMID:9585800
database_cross_reference: Reaxys:768009
has_exact_synonym: N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
has_related_synonym: ritonavir
id: CHEBI:45409

ChemIDplus
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: CAS:155213-67-5

DrugCentral
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: Drug_Central:2391

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363086

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363184

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363300

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363329

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363397

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11363517

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:11996889

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:24202050

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:8568292

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:9140265

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:9278209

Europe PMC
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: PMID:9585800

Reaxys
type: Axiom
annotated source: ritonavir
annotated property: database_cross_reference
annotated target: Reaxys:768009

imatinib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: tyrosine kinase inhibitor
subclass of: Restriction
  on property: has role
  some values from: apoptosis inducer
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.
database_cross_reference: Beilstein:7671333
database_cross_reference: CAS:152459-95-5
database_cross_reference: DrugBank:DB00619
database_cross_reference: Drug_Central:1423
database_cross_reference: LINCS:LSM-1023
database_cross_reference: PMID:14660054
database_cross_reference: PMID:14715630
database_cross_reference: PMID:15073101
database_cross_reference: PMID:15170967
database_cross_reference: PMID:15722647
database_cross_reference: PMID:15794712
database_cross_reference: PMID:15966213
database_cross_reference: PMID:16122278
database_cross_reference: PMID:16826359
database_cross_reference: PMID:16983347
database_cross_reference: PMID:17190842
database_cross_reference: PMID:17410337
database_cross_reference: PMID:17457302
database_cross_reference: PMID:17717205
database_cross_reference: PMID:18193246
database_cross_reference: PMID:18216472
database_cross_reference: PMID:18337118
database_cross_reference: PMID:18344535
database_cross_reference: PMID:18376233
database_cross_reference: PMID:18407734
database_cross_reference: PMID:18420270
database_cross_reference: PMID:18423008
database_cross_reference: PMID:18548219
database_cross_reference: PMID:18623899
database_cross_reference: PMID:18780518
database_cross_reference: PMID:18809244
database_cross_reference: PMID:19020005
database_cross_reference: PMID:19052981
database_cross_reference: PMID:19077095
database_cross_reference: PMID:19097599
database_cross_reference: PMID:19182535
database_cross_reference: PMID:19242505
database_cross_reference: PMID:19415889
database_cross_reference: PMID:19527930
database_cross_reference: PMID:19591692
database_cross_reference: PMID:19693287
database_cross_reference: PMID:19749465
database_cross_reference: PMID:19810774
database_cross_reference: PMID:19853594
database_cross_reference: PMID:19920908
database_cross_reference: PMID:22891806
database_cross_reference: PMID:23075630
database_cross_reference: PMID:23183914
database_cross_reference: PMID:23313020
database_cross_reference: PMID:23394269
database_cross_reference: PMID:23480638
database_cross_reference: PMID:23503753
database_cross_reference: PMID:23536338
database_cross_reference: PMID:23574742
database_cross_reference: PMID:23580311
database_cross_reference: PMID:23587588
database_cross_reference: Reaxys:7671333
has_exact_synonym: 4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
has_related_synonym: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
has_related_synonym: STI 571
has_related_synonym: alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
has_related_synonym: imatinib
id: CHEBI:45783

Beilstein
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: Beilstein:7671333

ChemIDplus
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: CAS:152459-95-5

DrugCentral
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: Drug_Central:1423

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:14660054

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:14715630

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:15073101

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:15170967

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:15722647

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:15794712

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:15966213

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:16122278

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:16826359

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:16983347

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:17190842

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:17410337

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:17457302

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:17717205

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18193246

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18216472

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18337118

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18344535

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18376233

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18407734

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18420270

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18423008

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18548219

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18623899

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18780518

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:18809244

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19020005

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19052981

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19077095

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19097599

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19182535

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19242505

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19415889

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19527930

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19591692

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19693287

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19749465

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19810774

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19853594

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:19920908

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:22891806

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23075630

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23183914

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23313020

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23394269

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23480638

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23503753

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23536338

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23574742

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23580311

Europe PMC
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: PMID:23587588

Reaxys
type: Axiom
annotated source: imatinib
annotated property: database_cross_reference
annotated target: Reaxys:7671333

thiabendazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antinematodal drug
subclass of: Restriction
  on property: has role
  some values from: antifungal agrochemical
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.
database_cross_reference: Beilstein:611403
database_cross_reference: CAS:148-79-8
database_cross_reference: DrugBank:DB00730
database_cross_reference: Drug_Central:2621
database_cross_reference: LINCS:LSM-3741
database_cross_reference: PMID:11226373
database_cross_reference: PMID:13900465
database_cross_reference: PMID:23790859
database_cross_reference: PMID:9009055
database_cross_reference: Pesticides:thiabendazole
database_cross_reference: Reaxys:611403
has_exact_synonym: 2-(1,3-thiazol-4-yl)-1H-benzimidazole
has_exact_synonym: Thiabendazole
has_related_synonym: 2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE
has_related_synonym: 2-(1,3-thiazol-4-yl)benzimidazole
has_related_synonym: 2-(4-thiazolyl)-1H-benzimidazole
has_related_synonym: 2-(thiazol-4-yl)benzimidazole
has_related_synonym: 4-(2-benzimidazolyl)thiazole
has_related_synonym: Equizole
has_related_synonym: MK 360
has_related_synonym: Mintezol
has_related_synonym: TBZ
has_related_synonym: Thibenzole
has_related_synonym: Tiabendazole
id: CHEBI:45979

Beilstein
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: Beilstein:611403

ChemIDplus
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: CAS:148-79-8

NIST Chemistry WebBook
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: CAS:148-79-8

DrugCentral
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: Drug_Central:2621

Europe PMC
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: PMID:11226373

Europe PMC
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: PMID:13900465

Europe PMC
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: PMID:23790859

Europe PMC
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: PMID:9009055

Alan Wood's Pesticides
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: Pesticides:thiabendazole

Reaxys
type: Axiom
annotated source: thiabendazole
annotated property: database_cross_reference
annotated target: Reaxys:611403

tacrine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: acetylcholinesterase inhibitor role
definition: A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
formula: C13H14N2
smiles: Nc1c2CCCCc2nc2ccccc12
database_cross_reference: CAS:321-64-2
database_cross_reference: DrugBank:DB00382
database_cross_reference: Wikipedia:Tacrine
has_exact_synonym: 1,2,3,4-tetrahydroacridin-9-amine

fluconazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: P450 inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
database_cross_reference: Beilstein:4269710
database_cross_reference: CAS:86386-73-4
database_cross_reference: DrugBank:DB00196
database_cross_reference: Drug_Central:1187
database_cross_reference: LINCS:LSM-2106
database_cross_reference: PMID:11366931
database_cross_reference: PMID:16822276
database_cross_reference: PMID:23171950
database_cross_reference: PMID:23793863
database_cross_reference: Reaxys:7311650
has_exact_synonym: 2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol
has_exact_synonym: fluconazole
has_related_synonym: 2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
has_related_synonym: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
has_related_synonym: Biozole
has_related_synonym: Diflucan
has_related_synonym: Elazor
has_related_synonym: Triflucan
has_related_synonym: fluconazol
has_related_synonym: fluconazole
has_related_synonym: fluconazolum
id: CHEBI:46081

Beilstein
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: Beilstein:4269710

ChemIDplus
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: CAS:86386-73-4

DrugCentral
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: Drug_Central:1187

Europe PMC
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: PMID:11366931

Europe PMC
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: PMID:16822276

Europe PMC
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: PMID:23171950

Europe PMC
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: PMID:23793863

Reaxys
type: Axiom
annotated source: fluconazole
annotated property: database_cross_reference
annotated target: Reaxys:7311650

paracetamol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
formula: C8H9NO2
smiles: CC(=O)Nc1ccc(O)cc1
database_cross_reference: CAS:103-90-2
database_cross_reference: DrugBank:DB00316
database_cross_reference: Wikipedia:Acetaminophen
database_cross_reference: Wikipedia:Paracetamol
has_exact_synonym: N-(4-hydroxyphenyl)acetamide
has_related_synonym: APAP
has_related_synonym: Acetaminophen

disulfiram
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: fungicide
subclass of: Restriction
  on property: has role
  some values from: EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: EC 3.1.1.8 (cholinesterase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: angiogenesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 5.99.1.2 (DNA topoisomerase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: apoptosis inducer
subclass of: Restriction
  on property: has role
  some values from: NF-kappaB inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 3.1.1.1 (carboxylesterase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
formula: C10H20N2S4
smiles: S(SC(N(CC)CC)=S)C(N(CC)CC)=S
database_cross_reference: CAS:97-77-8
database_cross_reference: DrugBank:DB00822
database_cross_reference: Drug_Central:928
database_cross_reference: LINCS:LSM-5467
database_cross_reference: PMID:10841824
database_cross_reference: PMID:11005259
database_cross_reference: PMID:11716515
database_cross_reference: PMID:14978246
database_cross_reference: PMID:15325261
database_cross_reference: PMID:15709459
database_cross_reference: PMID:16426571
database_cross_reference: PMID:16661923
database_cross_reference: PMID:16666414
database_cross_reference: PMID:16880974
database_cross_reference: PMID:17079463
database_cross_reference: PMID:17579916
database_cross_reference: PMID:17667894
database_cross_reference: PMID:18579431
database_cross_reference: PMID:19720750
database_cross_reference: PMID:19782464
database_cross_reference: PMID:19787200
database_cross_reference: PMID:21471244
database_cross_reference: PMID:24496638
database_cross_reference: PMID:25133664
database_cross_reference: PMID:25445071
database_cross_reference: PMID:25464072
database_cross_reference: PMID:25476326
database_cross_reference: PMID:25495604
database_cross_reference: PMID:25557293
database_cross_reference: PMID:25565438
database_cross_reference: PMID:25657800
database_cross_reference: PMID:25777347
database_cross_reference: PMID:26033731
database_cross_reference: PMID:26224731
database_cross_reference: PMID:26235918
database_cross_reference: PMID:26239994
database_cross_reference: PMID:26314552
database_cross_reference: PMID:26517513
database_cross_reference: PMID:26550292
database_cross_reference: PMID:8442800
database_cross_reference: PMID:8572926
database_cross_reference: Reaxys:1712560
database_cross_reference: Wikipedia:Disulfiram
has_exact_synonym: Disulfiram
has_related_synonym: 1,1'-dithiobis(N,N-diethylthioformamide)
has_related_synonym: Antabuse
has_related_synonym: N,N,N',N'-tetraethylthiuram disulfide
has_related_synonym: Tetraethylthiuram disulfide
has_related_synonym: bis(diethylthiocarbamoyl) disulfide
has_related_synonym: tetraethylthioperoxydicarbonic diamide
has_related_synonym: tetraethylthiuram disulfide
has_related_synonym: tetraethylthiuram disulphide
id: CHEBI:4659

ChemIDplus
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: CAS:97-77-8

NIST Chemistry WebBook
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: CAS:97-77-8

DrugCentral
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: Drug_Central:928

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:10841824

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:11005259

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
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Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:15325261

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:16880974

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:17079463

Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:17667894

Europe PMC
type: Axiom
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:19787200

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:21471244

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:24496638

Europe PMC
type: Axiom
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Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25445071

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25464072

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25476326

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25495604

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25557293

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25565438

Europe PMC
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: PMID:25657800

Europe PMC
type: Axiom
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annotated property: database_cross_reference
annotated target: PMID:25777347

Europe PMC
type: Axiom
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
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Europe PMC
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Europe PMC
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
annotated source: disulfiram
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Europe PMC
type: Axiom
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Reaxys
type: Axiom
annotated source: disulfiram
annotated property: database_cross_reference
annotated target: Reaxys:1712560

solvent
type: Class
subclass of: chemical role
definition: A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
database_cross_reference: Wikipedia:Solvent

diclofenac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
formula: C14H11Cl2NO2
smiles: C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl
database_cross_reference: ATC:D11AX18
database_cross_reference: ATC:M01AB05
database_cross_reference: ATC:M02AA15
database_cross_reference: ATC:S01BC03
database_cross_reference: Beilstein:2146636
database_cross_reference: CAS:15307-86-5
database_cross_reference: DrugBank:DB00586
database_cross_reference: Drug_Central:865
database_cross_reference: LINCS:LSM-2160
database_cross_reference: PMID:11322639
database_cross_reference: PMID:1502708
database_cross_reference: PMID:23777257
database_cross_reference: PMID:27967303
database_cross_reference: PMID:7838674
database_cross_reference: Reaxys:2146636
database_cross_reference: Wikipedia:Diclofenac
has_exact_synonym: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
has_exact_synonym: Diclofenac
has_exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
has_related_synonym: 2-((2,6-dichlorophenyl)amino)benzeneacetic acid
has_related_synonym: [2-(2,6-dichloroanilino)phenyl]acetic acid
has_related_synonym: diclofenac
has_related_synonym: diclofenac acid
has_related_synonym: diclofenaco
has_related_synonym: diclofenacum
has_related_synonym: diclofenamic acid
id: CHEBI:47381

Beilstein
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: Beilstein:2146636

ChemIDplus
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: CAS:15307-86-5

NIST Chemistry WebBook
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: CAS:15307-86-5

DrugCentral
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: Drug_Central:865

Europe PMC
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: PMID:11322639

Europe PMC
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: PMID:1502708

Europe PMC
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: PMID:23777257

Europe PMC
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: PMID:27967303

Europe PMC
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: PMID:7838674

Reaxys
type: Axiom
annotated source: diclofenac
annotated property: database_cross_reference
annotated target: Reaxys:2146636

caspofungin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
definition: A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
database_cross_reference: Beilstein:8471798
database_cross_reference: CAS:162808-62-0
database_cross_reference: DrugBank:DB00520
database_cross_reference: Drug_Central:2977
database_cross_reference: PMID:24270605
has_exact_synonym: (10R,12S)-N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
has_exact_synonym: Caspofungin
has_related_synonym: (4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide
has_related_synonym: 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0
has_related_synonym: caspofungin
id: CHEBI:474180

Beilstein
type: Axiom
annotated source: caspofungin
annotated property: database_cross_reference
annotated target: Beilstein:8471798

ChemIDplus
type: Axiom
annotated source: caspofungin
annotated property: database_cross_reference
annotated target: CAS:162808-62-0

DrugCentral
type: Axiom
annotated source: caspofungin
annotated property: database_cross_reference
annotated target: Drug_Central:2977

Europe PMC
type: Axiom
annotated source: caspofungin
annotated property: database_cross_reference
annotated target: PMID:24270605

imipramine
type: Class
subclass of: organic molecular entity
definition: Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
formula: C19H24N2
smiles: CN(C)CCCN1c2ccccc2CCc2ccccc12
database_cross_reference: DrugBank:DB00458
database_cross_reference: Open TG-Gates compound_id:00069
database_cross_reference: Wikipedia:Imipramine
database_cross_reference: https://livertox.nlm.nih.gov//Imipramine.htm

ketoconazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
database_cross_reference: Beilstein:4303081
database_cross_reference: CAS:65277-42-1
database_cross_reference: DrugBank:DB01026
database_cross_reference: Gmelin:1713206
database_cross_reference: Open TG-Gates compound_id=00047
has_exact_synonym: rac-1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
has_related_synonym: (+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
has_related_synonym: Fungarest
has_related_synonym: Fungoral
has_related_synonym: Ketoderm
has_related_synonym: Ketoisdin
has_related_synonym: Nizoral
has_related_synonym: Panfungol
has_related_synonym: Xolegel
has_related_synonym: cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
has_related_synonym: ketoconazol
has_related_synonym: ketoconazole
has_related_synonym: ketoconazolum
id: CHEBI:47519

ChemIDplus
type: Axiom
annotated source: ketoconazole
annotated property: database_cross_reference
annotated target: Beilstein:4303081

ChemIDplus
type: Axiom
annotated source: ketoconazole
annotated property: database_cross_reference
annotated target: CAS:65277-42-1

Gmelin
type: Axiom
annotated source: ketoconazole
annotated property: database_cross_reference
annotated target: Gmelin:1713206

clomipramine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: serotonergic drug
subclass of: Restriction
  on property: has role
  some values from: serotonergic antagonist
subclass of: Restriction
  on property: has role
  some values from: serotonin uptake inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
formula: C19H23ClN2
database_cross_reference: Beilstein:1323477
database_cross_reference: CAS:303-49-1
database_cross_reference: CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
database_cross_reference: DrugBank:DB01242
database_cross_reference: Drug_Central:701
database_cross_reference: LINCS:LSM-3171
database_cross_reference: Open TG-Gates compound_id:00121
database_cross_reference: PMID:12007764
database_cross_reference: PMID:12084414
database_cross_reference: PMID:16085036
database_cross_reference: PMID:17471183
database_cross_reference: PMID:19747949
database_cross_reference: PMID:19810911
database_cross_reference: Patent:US3467650
database_cross_reference: Reaxys:1323477
has_exact_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
has_exact_synonym: Clomipramine
has_related_synonym: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
has_related_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
has_related_synonym: 3-chloroimipramine
has_related_synonym: G 34586
has_related_synonym: chlorimipramine
has_related_synonym: monochlorimipramine
id: CHEBI:47780

ChemIDplus
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: Beilstein:1323477

ChemIDplus
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: CAS:303-49-1

NIST Chemistry WebBook
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: CAS:303-49-1

DrugCentral
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: Drug_Central:701

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:12007764

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:12084414

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:16085036

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:17471183

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:19747949

Europe PMC
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: PMID:19810911

Reaxys
type: Axiom
annotated source: clomipramine
annotated property: database_cross_reference
annotated target: Reaxys:1323477

photosensitizing agent
type: Class
subclass of: drug
definition: A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
has_related_synonym: photosensitising agent
id: CHEBI:47868

protein synthesis inhibitor
type: Class
subclass of: pathway inhibitor
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: TXPO_0000382
definition: A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
has_related_synonym: protein synthesis antagonist
has_related_synonym: protein synthesis antagonists
has_related_synonym: protein synthesis inhibitors
id: CHEBI:48001

serotonergic drug
type: Class
subclass of: neurotransmitter agent
has_related_synonym: serotonergic agents
has_related_synonym: serotonergic drugs
has_related_synonym: serotonin drugs
id: CHEBI:48278

serotonergic antagonist
type: Class
subclass of: serotonergic drug
definition: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
has_related_synonym: 5-HT antagonists
has_related_synonym: 5-hydroxytryptamine antagonists
has_related_synonym: antiserotonergic agents
has_related_synonym: serotonin antagonists
has_related_synonym: serotonin blockaders
id: CHEBI:48279

EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
definition: An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).
has_related_synonym: COMT inhibitor
has_related_synonym: COMT inhibitors
has_related_synonym: EC 2.1.1.6 (catechol O-methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.6 inhibitor
has_related_synonym: EC 2.1.1.6 inhibitors
has_related_synonym: S-adenosyl-L-methionine:catechol O-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:catechol O-methyltransferase inhibitors
has_related_synonym: catechol O-methyltransferase (EC 2.1.1.6) inhibitor
has_related_synonym: catechol O-methyltransferase (EC 2.1.1.6) inhibitors
has_related_synonym: catechol O-methyltransferase inhibitor
has_related_synonym: catechol O-methyltransferase inhibitors
has_related_synonym: catechol methyltransferase inhibitor
has_related_synonym: catechol methyltransferase inhibitors
has_related_synonym: catecholamine O-methyltransferase inhibitor
has_related_synonym: catecholamine O-methyltransferase inhibitors
id: CHEBI:48406

antiparkinson drug
type: Class
subclass of: drug
subclass of: antidyskinesia agent
definition: A drug used in the treatment of Parkinson's disease.
database_cross_reference: Wikipedia:Antiparkinson
has_related_synonym: antiparkinson agent
id: CHEBI:48407

angiogenesis inhibitor
type: Class
subclass of: drug
definition: An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
has_related_synonym: angiogenesis antagonist
has_related_synonym: angiostatic agents
has_related_synonym: anti-angiogenic agent
id: CHEBI:48422

erythromycin estolate
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
formula: C40H71NO14.C12H26O4S

alpha-adrenergic drug
type: Class
subclass of: adrenergic agent
definition: Any drug that acts on an alpha-adrenergic receptor.
has_related_synonym: alpha-adrenergic drugs
id: CHEBI:48539

beta-adrenergic drug
type: Class
subclass of: adrenergic agent
definition: Any of the drugs that act on beta-adrenergic receptors.
has_related_synonym: beta-adrenergic drugs
id: CHEBI:48540

tolrestat
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: EC 1.1.1.21 (aldehyde reductase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:4208277
database_cross_reference: CAS:82964-04-3
database_cross_reference: DrugBank:DB02383
database_cross_reference: Drug_Central:2704
has_exact_synonym: N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbonothioyl}-N-methylglycine
has_exact_synonym: TOLRESTAT
has_exact_synonym: Tolrestat
has_related_synonym: Alredase
has_related_synonym: N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methylglycine
has_related_synonym: N-{[6-methoxy-5-(trifluoromethyl)-1-naphthyl]carbonothioyl}-N-methylglycine
has_related_synonym: tolrestat
has_related_synonym: tolrestatum
id: CHEBI:48549

Beilstein
type: Axiom
annotated source: tolrestat
annotated property: database_cross_reference
annotated target: Beilstein:4208277

ChemIDplus
type: Axiom
annotated source: tolrestat
annotated property: database_cross_reference
annotated target: CAS:82964-04-3

DrugCentral
type: Axiom
annotated source: tolrestat
annotated property: database_cross_reference
annotated target: Drug_Central:2704

EC 1.1.1.21 (aldehyde reductase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
has_related_synonym: ALR2 inhibitor
has_related_synonym: ALR2 inhibitors
has_related_synonym: EC 1.1.1.21 (aldehyde reductase) inhibitors
has_related_synonym: EC 1.1.1.21 inhibitor
has_related_synonym: EC 1.1.1.21 inhibitors
has_related_synonym: NADPH-aldopentose reductase inhibitor
has_related_synonym: NADPH-aldopentose reductase inhibitors
has_related_synonym: NADPH-aldose reductase inhibitor
has_related_synonym: NADPH-aldose reductase inhibitors
has_related_synonym: aldehyde reductase (EC 1.1.1.21) inhibitor
has_related_synonym: aldehyde reductase (EC 1.1.1.21) inhibitors
has_related_synonym: aldehyde reductase inhibitor
has_related_synonym: aldehyde reductase inhibitors
has_related_synonym: alditol:NAD(P)(+) 1-oxidoreductase inhibitor
has_related_synonym: alditol:NAD(P)(+) 1-oxidoreductase inhibitors
has_related_synonym: alditol:NADP oxidoreductase inhibitor
has_related_synonym: alditol:NADP oxidoreductase inhibitors
has_related_synonym: alditol:NADP(+) 1-oxidoreductase inhibitor
has_related_synonym: alditol:NADP(+) 1-oxidoreductase inhibitors
has_related_synonym: aldose reductase inhibitor
has_related_synonym: aldose reductase inhibitors
has_related_synonym: polyol dehydrogenase (NADP(+)) inhibitor
has_related_synonym: polyol dehydrogenase (NADP(+)) inhibitors
id: CHEBI:48550

dopaminergic agent
type: Class
subclass of: neurotransmitter agent
definition: A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
has_related_synonym: dopamine agent
has_related_synonym: dopamine agents
has_related_synonym: dopamine drug
has_related_synonym: dopamine drugs
has_related_synonym: dopaminergic agents
id: CHEBI:48560

dopaminergic antagonist
type: Class
subclass of: dopaminergic agent
definition: A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
has_related_synonym: dopamine antagonist
has_related_synonym: dopamine blocker
has_related_synonym: dopamine receptor antagonist
has_related_synonym: dopaminergic antagonists
id: CHEBI:48561

radical scavenger
type: Class
subclass of: antioxidant
definition: A role played by a substance that can react readily with, and thereby eliminate, radicals.
has_related_synonym: free radical scavenger
has_related_synonym: free radical scavengers
has_related_synonym: free-radical scavenger
id: CHEBI:48578

fibrin modulating drug
type: Class
subclass of: drug
definition: A drug that affects the function of fibrin in blood coagulation.
has_related_synonym: fibrin modulating agent
has_related_synonym: fibrin modulating agents
has_related_synonym: fibrin modulating drugs
id: CHEBI:48676

estramustine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: alkylating agent
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: radiation protective agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
database_cross_reference: Beilstein:5637599
database_cross_reference: CAS:2998-57-4
database_cross_reference: DrugBank:DB01196
database_cross_reference: Drug_Central:1065
database_cross_reference: LIPID_MAPS_instance:LMST02010038
database_cross_reference: PMID:11131983
database_cross_reference: PMID:15762353
database_cross_reference: PMID:7638085
database_cross_reference: Reaxys:5637599
has_exact_synonym: (17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate
has_exact_synonym: Estramustine
has_related_synonym: 17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)
has_related_synonym: Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)
has_related_synonym: estramustina
has_related_synonym: estramustine
has_related_synonym: estramustinum
id: CHEBI:4868

Beilstein
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: Beilstein:5637599

ChemIDplus
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: CAS:2998-57-4

DrugCentral
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: Drug_Central:1065

LIPID MAPS
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMST02010038

Europe PMC
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: PMID:11131983

Europe PMC
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: PMID:15762353

Europe PMC
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: PMID:7638085

Reaxys
type: Axiom
annotated source: estramustine
annotated property: database_cross_reference
annotated target: Reaxys:5637599

agonist
type: Class
subclass of: pharmacological role
definition: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
has_exact_synonym: agonist
has_related_synonym: agonista
has_related_synonym: agoniste
has_related_synonym: agonists
id: CHEBI:48705

antagonist
type: Class
subclass of: pharmacological role
definition: Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
has_exact_synonym: antagonist
has_related_synonym: antagonista
has_related_synonym: antagoniste
has_related_synonym: antagonists
id: CHEBI:48706

ethambutol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antitubercular agent
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.
database_cross_reference: Beilstein:6312870
database_cross_reference: CAS:74-55-5
database_cross_reference: DrugBank:DB00330
database_cross_reference: Drug_Central:1073
database_cross_reference: PMID:10649975
database_cross_reference: PMID:10891117
database_cross_reference: PMID:10966749
database_cross_reference: PMID:12182855
database_cross_reference: PMID:14695841
database_cross_reference: PMID:14698152
database_cross_reference: PMID:15225698
database_cross_reference: PMID:16005211
database_cross_reference: PMID:16759086
database_cross_reference: PMID:16870429
database_cross_reference: PMID:17210775
database_cross_reference: PMID:17239593
database_cross_reference: PMID:17276683
database_cross_reference: PMID:17315960
database_cross_reference: PMID:17331717
database_cross_reference: PMID:17562368
database_cross_reference: PMID:17851083
database_cross_reference: PMID:17888665
database_cross_reference: PMID:19524332
database_cross_reference: PMID:19648006
database_cross_reference: PMID:3934384
database_cross_reference: Reaxys:6312870
has_exact_synonym: (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
has_exact_synonym: Ethambutol
has_related_synonym: (+)-2,2'-(ethylenediimino)di-1-butanol
has_related_synonym: (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine
has_related_synonym: (+)-S,S-ethambutol
has_related_synonym: (+)-ethambutol
has_related_synonym: (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol
has_related_synonym: (S,S)-ethambutol
has_related_synonym: EMB
has_related_synonym: S,S-Ethambutol
has_related_synonym: etambutol
has_related_synonym: ethambutol
has_related_synonym: ethambutolum
id: CHEBI:4877

Beilstein
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: Beilstein:6312870

ChemIDplus
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: CAS:74-55-5

DrugCentral
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: Drug_Central:1073

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:10649975

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:10891117

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:10966749

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:12182855

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:14695841

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:14698152

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:15225698

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:16005211

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:16759086

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:16870429

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17210775

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17239593

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17276683

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17315960

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17331717

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17562368

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17851083

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:17888665

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:19524332

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:19648006

ChEMBL
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: PMID:3934384

Reaxys
type: Axiom
annotated source: ethambutol
annotated property: database_cross_reference
annotated target: Reaxys:6312870

ethionamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: fatty acid synthesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001996
definition: A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.
formula: C8H10N2S
smiles: CCc1cc(ccn1)C(N)=S
database_cross_reference: CAS:536-33-4
database_cross_reference: DrugBank:DB00609
database_cross_reference: Wikipedia:Ethionamide
has_exact_synonym: 2-ethylpyridine-4-carbothioamide

cholinergic antagonist
type: Class
subclass of: cholinergic drug
definition: Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
has_related_synonym: Anticholinergika
has_related_synonym: Anticholinergikum
has_related_synonym: acetylcholine antagonists
has_related_synonym: acetylcholine receptor antagonist
has_related_synonym: agent anticholinergique
has_related_synonym: agente anticolinergico
has_related_synonym: agentes anticolinergicos
has_related_synonym: anticholinergic agents
has_related_synonym: anticholinergics
has_related_synonym: anticholinergiques
has_related_synonym: anticolinergicos
has_related_synonym: cholinergic-blocking agents
id: CHEBI:48873

muscarinic antagonist
type: Class
subclass of: cholinergic antagonist
definition: A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
has_related_synonym: Antimuskarinika
has_related_synonym: Antimuskarinikum
has_related_synonym: agente antimuscarinico
has_related_synonym: agentes antimuscarinicos
has_related_synonym: agents antimuscariniques
has_related_synonym: antimuscarinic agents
has_related_synonym: antimuscarinicos
has_related_synonym: muscarinic acetylcholine receptor antagonist
has_related_synonym: muscarinic antagonists
id: CHEBI:48876

bile acid metabolite
type: Class
subclass of: metabolite
definition: Metabolites of bile acids, four-ringed steroid acids formed along the cholesterol degradation pathway.

erythromycin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: bacterial metabolite
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).
database_cross_reference: DrugBank:DB00199
has_related_synonym: eritromicina
has_related_synonym: erthromycin
has_related_synonym: erythromycine
id: CHEBI:48923

deferasirox
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: iron chelator
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.
database_cross_reference: Beilstein:8442898
database_cross_reference: CAS:201530-41-8
database_cross_reference: DrugBank:DB01609
database_cross_reference: Drug_Central:3128
database_cross_reference: Reaxys:8442898
has_exact_synonym: 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
has_related_synonym: Exjade
has_related_synonym: ICL 670
has_related_synonym: ICL 670A
has_related_synonym: deferasirox
has_related_synonym: deferasiroxum
id: CHEBI:49005

Beilstein
type: Axiom
annotated source: deferasirox
annotated property: database_cross_reference
annotated target: Beilstein:8442898

ChemIDplus
type: Axiom
annotated source: deferasirox
annotated property: database_cross_reference
annotated target: CAS:201530-41-8

DrugCentral
type: Axiom
annotated source: deferasirox
annotated property: database_cross_reference
annotated target: Drug_Central:3128

Reaxys
type: Axiom
annotated source: deferasirox
annotated property: database_cross_reference
annotated target: Reaxys:8442898

hormone antagonist
type: Class
subclass of: antagonist
subclass of: hormone receptor modulator
definition: A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
has_related_synonym: hormone antagonists
id: CHEBI:49020

didanosine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.
formula: C10H12N4O3
smiles: OC[C@@H]1CC[C@@H](O1)n1cnc2c1nc[nH]c2=O
database_cross_reference: Beilstein:3619529
database_cross_reference: CAS:69655-05-6
database_cross_reference: DrugBank:DB00900
database_cross_reference: Drug_Central:869
database_cross_reference: LINCS:LSM-6017
database_cross_reference: PMID:10386939
database_cross_reference: PMID:1619614
database_cross_reference: PMID:17046264
database_cross_reference: PMID:18549801
database_cross_reference: PMID:29438107
database_cross_reference: Reaxys:3619529
database_cross_reference: Wikipedia:Didanosine
has_exact_synonym: 2',3'-dideoxyinosine
has_exact_synonym: Didanosine
has_exact_synonym: ddI
has_related_synonym: 2,3-dideoxyinosine
has_related_synonym: 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
has_related_synonym: 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
has_related_synonym: 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol
has_related_synonym: 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
has_related_synonym: DDI
has_related_synonym: ddI
has_related_synonym: ddIno
has_related_synonym: didanosina
has_related_synonym: didanosine
has_related_synonym: didanosinum
has_related_synonym: dideoxyinosine
id: CHEBI:490877

Beilstein
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: Beilstein:3619529

ChemIDplus
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: CAS:69655-05-6

DrugCentral
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: Drug_Central:869

ChEMBL
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: PMID:10386939

ChEMBL
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: PMID:1619614

ChEMBL
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: PMID:17046264

Europe PMC
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: PMID:18549801

Europe PMC
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: PMID:29438107

Reaxys
type: Axiom
annotated source: didanosine
annotated property: database_cross_reference
annotated target: Reaxys:3619529

etodolac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 2 inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
database_cross_reference: CAS:41340-25-4
database_cross_reference: DrugBank:DB00749
database_cross_reference: Drug_Central:1103
database_cross_reference: LINCS:LSM-1781
database_cross_reference: PMID:15369391
database_cross_reference: PMID:2527995
database_cross_reference: PMID:28166217
database_cross_reference: PMID:2970548
has_exact_synonym: (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
has_exact_synonym: ETODOLAC
has_related_synonym: (+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
has_related_synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
has_related_synonym: 1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
has_related_synonym: 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
has_related_synonym: 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
has_related_synonym: ETODOLIC ACID
has_related_synonym: etodolac
has_related_synonym: etodolaco
has_related_synonym: etodolacum
id: CHEBI:4909

ChemIDplus
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: CAS:41340-25-4

DrugCentral
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: Drug_Central:1103

ChEMBL
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: PMID:15369391

ChEMBL
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: PMID:2527995

Europe PMC
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: PMID:28166217

ChEMBL
type: Axiom
annotated source: etodolac
annotated property: database_cross_reference
annotated target: PMID:2970548

drug metabolite
type: Class
subclass of: human xenobiotic metabolite
definition: Any human metabolite produced by metabolism of drugs in humans.
has_related_synonym: drug metabolites
id: CHEBI:49103

leukotriene antagonist
type: Class
subclass of: hormone antagonist
definition: A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
has_related_synonym: LTRA
has_related_synonym: leukotriene antagonists
has_related_synonym: leukotriene receptor antagonist
has_related_synonym: leukotriene receptor antagonists
id: CHEBI:49159

anti-asthmatic drug
type: Class
subclass of: drug
subclass of: anti-asthmatic agent
definition: A drug used to treat asthma.
has_related_synonym: anti-asthmatic agent
has_related_synonym: anti-asthmatic agents
has_related_synonym: anti-asthmatic drugs
id: CHEBI:49167

anti-ulcer drug
type: Class
subclass of: drug
definition: One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
has_related_synonym: anti-ulcer agent

contraceptive drug
type: Class
subclass of: reproductive control drug
definition: A chemical substance that prevents or reduces the probability of conception.
has_related_synonym: contraceptive agent
has_related_synonym: contraceptive drugs
id: CHEBI:49323

female contraceptive drug
type: Class
subclass of: contraceptive drug
definition: A chemical substance or agent with contraceptive activity in females.
has_related_synonym: female contraceptive agent
has_related_synonym: female contraceptive drugs
id: CHEBI:49324

exemestane
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.14.14 (aromatase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
database_cross_reference: CAS:107868-30-4
database_cross_reference: DrugBank:DB00990
database_cross_reference: Drug_Central:1122
database_cross_reference: PMID:10882163
database_cross_reference: Reaxys:6609645
has_exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
has_exact_synonym: Exemestane
has_related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione
has_related_synonym: exemestane
has_related_synonym: exemestano
has_related_synonym: exemestanum
id: CHEBI:4953

ChemIDplus
type: Axiom
annotated source: exemestane
annotated property: database_cross_reference
annotated target: CAS:107868-30-4

DrugCentral
type: Axiom
annotated source: exemestane
annotated property: database_cross_reference
annotated target: Drug_Central:1122

Europe PMC
type: Axiom
annotated source: exemestane
annotated property: database_cross_reference
annotated target: PMID:10882163

Reaxys
type: Axiom
annotated source: exemestane
annotated property: database_cross_reference
annotated target: Reaxys:6609645

lapatinib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: tyrosine kinase inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:10502247
database_cross_reference: CAS:231277-92-2
database_cross_reference: DrugBank:DB01259
database_cross_reference: Drug_Central:1548
database_cross_reference: LINCS:LSM-1051
has_related_synonym: GW 572016
has_related_synonym: N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
has_related_synonym: N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
has_related_synonym: Tykerb
id: CHEBI:49603

Beilstein
type: Axiom
annotated source: lapatinib
annotated property: database_cross_reference
annotated target: Beilstein:10502247

ChemIDplus
type: Axiom
annotated source: lapatinib
annotated property: database_cross_reference
annotated target: CAS:231277-92-2

DrugCentral
type: Axiom
annotated source: lapatinib
annotated property: database_cross_reference
annotated target: Drug_Central:1548

hydrogen atom
type: Class
subclass of: atom
has_exact_synonym: Inchikey:YZCKVEUIGOORGS-UHFFFAOYSA-N
has_exact_synonym: hydrogen

gefitinib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: epidermal growth factor receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.
database_cross_reference: CAS:184475-35-2
database_cross_reference: DrugBank:DB00317
database_cross_reference: Drug_Central:1282
database_cross_reference: LINCS:LSM-1098
database_cross_reference: PMID:14981586
database_cross_reference: PMID:15068398
database_cross_reference: PMID:20573926
database_cross_reference: PMID:20949670
database_cross_reference: PMID:27396387
database_cross_reference: PMID:28968167
database_cross_reference: PMID:29332330
database_cross_reference: PMID:29493460
database_cross_reference: PMID:29579334
database_cross_reference: PMID:29668619
database_cross_reference: PMID:30068310
database_cross_reference: PMID:30069771
database_cross_reference: PMID:30214852
database_cross_reference: Reaxys:8949523
has_exact_synonym: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
has_related_synonym: 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
has_related_synonym: Iressa
has_related_synonym: Irressat
has_related_synonym: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine
has_related_synonym: ZD 1839
has_related_synonym: ZD-1839
has_related_synonym: ZD1839
has_related_synonym: gefitinib
has_related_synonym: gefitinibum
id: CHEBI:49668

ChemIDplus
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annotated source: gefitinib
annotated property: database_cross_reference
annotated target: CAS:184475-35-2

DrugCentral
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: Drug_Central:1282

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:14981586

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:15068398

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:20573926

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:20949670

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:27396387

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:28968167

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:29332330

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:29493460

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:29579334

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:29668619

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:30068310

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:30069771

Europe PMC
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: PMID:30214852

Reaxys
type: Axiom
annotated source: gefitinib
annotated property: database_cross_reference
annotated target: Reaxys:8949523

felbamate
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has role
  some values from: neuroprotective agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
database_cross_reference: CAS:25451-15-4
database_cross_reference: DrugBank:DB00949
database_cross_reference: Drug_Central:1140
database_cross_reference: LINCS:LSM-4232
database_cross_reference: PMID:12825948
database_cross_reference: PMID:12873507
database_cross_reference: PMID:18311896
database_cross_reference: Reaxys:3345236
has_exact_synonym: 2-phenylpropane-1,3-diyl dicarbamate
has_exact_synonym: Felbamate
has_related_synonym: 2-phenyl-1,3-propanediol dicarbamate
has_related_synonym: Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester
has_related_synonym: carbamic acid 2-phenyltrimethylene ester
has_related_synonym: felbamate
has_related_synonym: felbamato
has_related_synonym: felbamatum
id: CHEBI:4995

ChemIDplus
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: CAS:25451-15-4

NIST Chemistry WebBook
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: CAS:25451-15-4

DrugCentral
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: Drug_Central:1140

ChEMBL
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annotated source: felbamate
annotated property: database_cross_reference
annotated target: PMID:12825948

ChEMBL
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: PMID:12873507

ChEMBL
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: PMID:18311896

Reaxys
type: Axiom
annotated source: felbamate
annotated property: database_cross_reference
annotated target: Reaxys:3345236

fenofibrate
type: Class
subclass of: TXPO_1000442
definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
database_cross_reference: LINCS:LSM-3107
has_exact_synonym: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

fenoprofen
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 2 inhibitor
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 1 inhibitor
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
database_cross_reference: CAS:31879-05-7
database_cross_reference: DrugBank:DB00573
database_cross_reference: Drug_Central:1154
database_cross_reference: PMID:21328296
database_cross_reference: PMID:21342694
database_cross_reference: PMID:25554116
database_cross_reference: PMID:28166217
database_cross_reference: PMID:30168706
database_cross_reference: PMID:4616811
database_cross_reference: Reaxys:2118687
has_exact_synonym: 2-(3-phenoxyphenyl)propanoic acid
has_exact_synonym: FENOPROFEN
has_exact_synonym: Fenoprofen
has_related_synonym: (+-)-2-(3-phenoxyphenyl)propionic acid
has_related_synonym: (+-)-m-phenoxyhydratropic acid
has_related_synonym: 2-(3-phenoxyphenyl)propionic acid
has_related_synonym: 2-(m-phenoxyphenyl)propionic acid
has_related_synonym: alpha-(m-phenoxyphenyl)propionic acid
has_related_synonym: alpha-methyl-3-phenoxybenzeneacetic acid
has_related_synonym: fenoprofen
has_related_synonym: fenoprofene
has_related_synonym: fenoprofeno
has_related_synonym: fenoprofenum
id: CHEBI:5004

ChemIDplus
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: CAS:31879-05-7

NIST Chemistry WebBook
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: CAS:31879-05-7

DrugCentral
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: Drug_Central:1154

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:21328296

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:21342694

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:25554116

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:28166217

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:30168706

Europe PMC
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: PMID:4616811

Reaxys
type: Axiom
annotated source: fenoprofen
annotated property: database_cross_reference
annotated target: Reaxys:2118687

sex hormone
type: Class
subclass of: hormone
definition: Any hormone that is responsible for controlling sexual characteristics and reproductive function.
has_related_synonym: Geschlechtshormon
has_related_synonym: Geschlechtshormone
has_related_synonym: Sexualhormon
has_related_synonym: Sexualhormone
has_related_synonym: hormone sexuelle
has_related_synonym: hormones sexuelles
has_related_synonym: sex hormones
id: CHEBI:50112

androgen
type: Class
subclass of: sex hormone
definition: A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
has_exact_synonym: Androgen
has_related_synonym: Androgene
has_related_synonym: androgene
has_related_synonym: androgenes
has_related_synonym: androgeno
has_related_synonym: androgenos
has_related_synonym: androgens
id: CHEBI:50113

estrogen
type: Class
subclass of: sex hormone
definition: A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
database_cross_reference: Wikipedia:Estrogen

rosiglitazone
type: Class
subclass of: organic molecular entity
smiles: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
database_cross_reference: CAS:122320-73-4
database_cross_reference: DrugBank:DB00412
database_cross_reference: Wikipedia:Rosiglitazone
has_exact_synonym: 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
has_exact_synonym: LINCS:LSM-1949

acitretin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.
database_cross_reference: CAS:54757-46-9
database_cross_reference: LINCS:LSM-5713
database_cross_reference: Reaxys:15057225
has_exact_synonym: 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
id: CHEBI:50172

ChemIDplus
type: Axiom
annotated source: acitretin
annotated property: database_cross_reference
annotated target: CAS:54757-46-9

Reaxys
type: Axiom
annotated source: acitretin
annotated property: database_cross_reference
annotated target: Reaxys:15057225

keratolytic drug
type: Class
subclass of: dermatologic drug
definition: A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
has_related_synonym: desquamating agent
has_related_synonym: keratolytic agent
has_related_synonym: keratolytic drugs
has_related_synonym: skin-peeling agent
id: CHEBI:50176

dermatologic drug
type: Class
subclass of: drug
definition: A drug used to treat or prevent skin disorders or for the routine care of skin.
has_related_synonym: dermatologic agent
has_related_synonym: dermatologic drugs
has_related_synonym: dermatological agent
id: CHEBI:50177

P450 inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
subclass of: EC 1.14.14.1 (unspecific monooxygenase) inhibitor
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: TXPO_0001758
definition: An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
has_related_synonym: CYP2D6 inhbitor
has_related_synonym: CYP2D6 inhbitors
has_related_synonym: P450 inhibitors
has_related_synonym: cytochrome P450 inhibitor
has_related_synonym: cytochrome P450 inhibitors
id: CHEBI:50183

fatty acid synthesis inhibitor
type: Class
subclass of: TXPO_0003648
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: fatty acid biosynthetic process
definition: Any pathway inhibitor that inhibits the synthesis of fatty acids.

hematologic agent
type: Class
subclass of: drug
definition: Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.
has_related_synonym: hematologic agents
id: CHEBI:50248

anticoagulant
type: Class
subclass of: hematologic agent
definition: An agent that prevents blood clotting.
has_related_synonym: anticoagulante
has_related_synonym: anticoagulants
id: CHEBI:50249

prodrug
type: Class
subclass of: drug
definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
database_cross_reference: PMID:23993918
database_cross_reference: PMID:23998799
database_cross_reference: PMID:24329110
database_cross_reference: PMID:24628402
database_cross_reference: PMID:24709544
database_cross_reference: PMID:25144792
database_cross_reference: PMID:25157234
database_cross_reference: PMID:25269430
database_cross_reference: PMID:25391982
database_cross_reference: PMID:25591121
database_cross_reference: PMID:25620096
database_cross_reference: PMID:25795057
database_cross_reference: PMID:26028253
database_cross_reference: PMID:26184144
database_cross_reference: PMID:28070577
database_cross_reference: PMID:28215138
database_cross_reference: PMID:28219047
database_cross_reference: PMID:28259775
database_cross_reference: PMID:28319647
database_cross_reference: PMID:28329729
database_cross_reference: PMID:28334528
has_related_synonym: Prodrugs
id: CHEBI:50266

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:23993918

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:23998799

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:24329110

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:24628402

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:24709544

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25144792

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25157234

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25269430

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25391982

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
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Europe PMC
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annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25620096

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:25795057

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
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Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:26184144

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28070577

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28215138

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28219047

Europe PMC
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annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28259775

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28319647

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28329729

Europe PMC
type: Axiom
annotated source: prodrug
annotated property: database_cross_reference
annotated target: PMID:28334528

protective agent
type: Class
subclass of: drug
definition: Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
has_related_synonym: chemoprotectant
has_related_synonym: chemoprotectants
has_related_synonym: chemoprotective agent
has_related_synonym: chemoprotective agents
has_related_synonym: protective agents
id: CHEBI:50267

EC 5.99.1.2 (DNA topoisomerase) inhibitor
type: Class
subclass of: topoisomerase inhibitor
definition: A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
has_related_synonym: DNA topoisomerase inhibitor
has_related_synonym: DNA topoisomerase inhibitors
has_related_synonym: EC 5.99.1.2 (DNA topoisomerase) inhibitors
has_related_synonym: EC 5.99.1.2 (topoisomerase I) inhibitor
has_related_synonym: EC 5.99.1.2 (topoisomerase I) inhibitors
has_related_synonym: EC 5.99.1.2 inhibitor
has_related_synonym: EC 5.99.1.2 inhibitors
has_related_synonym: topoisomerase I (EC 5.99.1.2) inhibitor
has_related_synonym: topoisomerase I (EC 5.99.1.2) inhibitors
has_related_synonym: topoisomerase I inhibitor
has_related_synonym: topoisomerase I inhibitors
has_related_synonym: type I DNA topoisomerase inhibitor
has_related_synonym: type I DNA topoisomerase inhibitors
id: CHEBI:50276

platelet aggregation inhibitor
type: Class
subclass of: hematologic agent
definition: A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
has_related_synonym: platelet aggregation inhibitors
id: CHEBI:50427

phospholipase A2 inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
has_exact_synonym: EC 3.1.1.4 (phospholipase A2) inhibitor

EC 2.5.1.15 (dihydropteroate synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
has_related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
has_related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
has_related_synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
has_related_synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
has_related_synonym: 7,8-dihydropteroate synthase inhibitor
has_related_synonym: 7,8-dihydropteroate synthase inhibitors
has_related_synonym: 7,8-dihydropteroate synthetase inhibitor
has_related_synonym: 7,8-dihydropteroate synthetase inhibitors
has_related_synonym: 7,8-dihydropteroic acid synthetase inhibitor
has_related_synonym: 7,8-dihydropteroic acid synthetase inhibitors
has_related_synonym: DHPS inhibitor
has_related_synonym: DHPS inhibitors
has_related_synonym: EC 2.5.1.15 (dihydropteroate synthase) inhibitors
has_related_synonym: EC 2.5.1.15 inhibitor
has_related_synonym: EC 2.5.1.15 inhibitors
has_related_synonym: dihydropteroate diphosphorylase inhibitor
has_related_synonym: dihydropteroate diphosphorylase inhibitors
has_related_synonym: dihydropteroate pyrophosphorylase inhibitor
has_related_synonym: dihydropteroate pyrophosphorylase inhibitors
has_related_synonym: dihydropteroate synthase (EC 2.5.1.15) inhibitor
has_related_synonym: dihydropteroate synthase (EC 2.5.1.15) inhibitors
has_related_synonym: dihydropteroate synthase inhibitor
has_related_synonym: dihydropteroate synthase inhibitors
has_related_synonym: dihydropteroate synthetase inhibitor
has_related_synonym: dihydropteroate synthetase inhibitors
has_related_synonym: dihydropteroic synthetase inhibitor
has_related_synonym: dihydropteroic synthetase inhibitors
id: CHEBI:50502

potassium channel modulator
type: Class
subclass of: membrane transport modulator

vasoconstrictor agent
type: Class
subclass of: cardiovascular drug
definition: Drug used to cause constriction of the blood vessels.

EC 3.2.1.1 (alpha-amylase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-amylase (EC 3.2.1.1).
has_related_synonym: 1,4-alpha-D-glucan glucanohydrolase inhibitor
has_related_synonym: 1,4-alpha-D-glucan glucanohydrolase inhibitors
has_related_synonym: 4-alpha-D-glucan glucanohydrolase inhibitor
has_related_synonym: 4-alpha-D-glucan glucanohydrolase inhibitors
has_related_synonym: EC 3.2.1.1 (alpha-amylase) inhibitors
has_related_synonym: EC 3.2.1.1 inhibitor
has_related_synonym: EC 3.2.1.1 inhibitors
has_related_synonym: Taka-amylase A inhibitor
has_related_synonym: Taka-amylase A inhibitors
has_related_synonym: alpha-amylase (EC 3.2.1.1) inhibitor
has_related_synonym: alpha-amylase (EC 3.2.1.1) inhibitors
has_related_synonym: alpha-amylase inhibitor
has_related_synonym: alpha-amylase inhibitors
has_related_synonym: endoamylase inhibitor
has_related_synonym: endoamylase inhibitors
has_related_synonym: glycogenase inhibitor
has_related_synonym: glycogenase inhibitors
id: CHEBI:50627

cyclooxygenase 2 inhibitor
type: Class
subclass of: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
definition: A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
has_related_synonym: COX-2 inhibitor
has_related_synonym: COX-2 inhibitors
has_related_synonym: PGHS-2 inhibitor
has_related_synonym: PGHS-2 inhibitors
has_related_synonym: cyclo-oxygenase 2 inhibitor
has_related_synonym: cyclo-oxygenase 2 inhibitors
has_related_synonym: cyclo-oxygenase-2 inhibitor
has_related_synonym: cyclo-oxygenase-2 inhibitors
has_related_synonym: cyclooxygenase 2 inhibitors
has_related_synonym: cyclooxygenase-2 inhibitor
has_related_synonym: cyclooxygenase-2 inhibitors
has_related_synonym: prostaglandin H synthase-2 inhibitor
has_related_synonym: prostaglandin H synthase-2 inhibitors
has_related_synonym: prostaglandin-endoperoxide synthase 2 inhibitor
has_related_synonym: prostaglandin-endoperoxide synthase 2 inhibitors
id: CHEBI:50629

cyclooxygenase 1 inhibitor
type: Class
subclass of: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
definition: A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
has_related_synonym: COX-1 inhibitor
has_related_synonym: COX-1 inhibitors
has_related_synonym: PTGS1 inhibitor
has_related_synonym: PTGS1 inhibitors
has_related_synonym: cyclo-oxygenase 1 inhibitor
has_related_synonym: cyclo-oxygenase 1 inhibitors
has_related_synonym: cyclooxygenase 1 inhibitors
has_related_synonym: cyclooxygenase-1 inhibitor
has_related_synonym: cyclooxygenase-1 inhibitors
has_related_synonym: prostaglandin G/H synthase 1 inhibitor
has_related_synonym: prostaglandin G/H synthase 1 inhibitors
has_related_synonym: prostaglandin H2 synthase 1 inhibitor
has_related_synonym: prostaglandin H2 synthase 1 inhibitors
has_related_synonym: prostaglandin-endoperoxide synthase 1 inhibitor
has_related_synonym: prostaglandin-endoperoxide synthase 1 inhibitors
id: CHEBI:50630

bone density conservation agent
type: Class
subclass of: drug
definition: An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
has_related_synonym: anti-osteopenia agent
has_related_synonym: anti-osteopenia agents
has_related_synonym: anti-osteopenia drug
has_related_synonym: anti-osteopenia drugs
has_related_synonym: anti-osteoporosis agent
has_related_synonym: anti-osteoporosis agents
has_related_synonym: anti-osteoporosis drug
has_related_synonym: anti-osteoporosis drugs
has_related_synonym: anti-osteoporotic
has_related_synonym: anti-osteoporotic agent
has_related_synonym: anti-osteoporotic agents
has_related_synonym: anti-osteoporotic drug
has_related_synonym: anti-osteoporotic drugs
has_related_synonym: anti-osteoporotics
has_related_synonym: antiosteoporotic
has_related_synonym: antiosteoporotics
has_related_synonym: bone density conservation agents
has_related_synonym: bone density conservation drug
has_related_synonym: bone density conservation drugs
id: CHEBI:50646

antithyroid drug
type: Class
subclass of: hormone antagonist
definition: A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
has_related_synonym: antithyroid agent
has_related_synonym: antithyroid agents
has_related_synonym: antithyroid drugs
id: CHEBI:50671

methimazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antithyroid drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.
database_cross_reference: Beilstein:108646
database_cross_reference: CAS:60-56-0
database_cross_reference: DrugBank:DB00763
database_cross_reference: Drug_Central:1745
database_cross_reference: LINCS:LSM-5646
database_cross_reference: PMID:17438883
database_cross_reference: PMID:24443787
database_cross_reference: PMID:7454742
database_cross_reference: PMID:9172960
database_cross_reference: Reaxys:108646
has_exact_synonym: 1-methyl-1,3-dihydro-2H-imidazole-2-thione
has_exact_synonym: Methimazole
has_related_synonym: 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE
has_related_synonym: 1-Methylimidazole-2(3H)-thione
has_related_synonym: Danantizol
has_related_synonym: Favistan
has_related_synonym: Strumazol
has_related_synonym: Tapazole
has_related_synonym: Thacapzol
has_related_synonym: USAF el-30
has_related_synonym: thiamazol
has_related_synonym: thiamazole
has_related_synonym: thiamazolum
has_related_synonym: tiamazol
id: CHEBI:50673

Beilstein
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: Beilstein:108646

ChemIDplus
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: CAS:60-56-0

NIST Chemistry WebBook
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: CAS:60-56-0

DrugCentral
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: Drug_Central:1745

Europe PMC
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: PMID:17438883

Europe PMC
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: PMID:24443787

Europe PMC
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: PMID:7454742

Europe PMC
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: PMID:9172960

Reaxys
type: Axiom
annotated source: methimazole
annotated property: database_cross_reference
annotated target: Reaxys:108646

EC 1.5.1.3 (dihydrofolate reductase) inhibitor
type: Class
subclass of: antifolate
subclass of: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
definition: An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
has_related_synonym: 7,8-dihydrofolate reductase inhibitor
has_related_synonym: 7,8-dihydrofolate reductase inhibitors
has_related_synonym: DHFR inhibitor
has_related_synonym: DHFR inhibitors
has_related_synonym: EC 1.5.1.3 (dihydrofolate reductase) inhibitors
has_related_synonym: EC 1.5.1.3 inhibitor
has_related_synonym: EC 1.5.1.3 inhibitors
has_related_synonym: NADPH-dihydrofolate reductase inhibitor
has_related_synonym: NADPH-dihydrofolate reductase inhibitors
has_related_synonym: dihydrofolate reductase (EC 1.5.1.3) inhibitor
has_related_synonym: dihydrofolate reductase (EC 1.5.1.3) inhibitors
has_related_synonym: dihydrofolate reductase inhibitor
has_related_synonym: dihydrofolate reductase inhibitors
has_related_synonym: dihydrofolic acid reductase inhibitor
has_related_synonym: dihydrofolic acid reductase inhibitors
has_related_synonym: dihydrofolic reductase inhibitor
has_related_synonym: dihydrofolic reductase inhibitors
has_related_synonym: folic acid reductase inhibitor
has_related_synonym: folic acid reductase inhibitors
has_related_synonym: folic reductase inhibitor
has_related_synonym: folic reductase inhibitors
has_related_synonym: tetrahydrofolate dehydrogenase inhibitor
has_related_synonym: tetrahydrofolate dehydrogenase inhibitors
id: CHEBI:50683

reproductive control drug
type: Class
subclass of: drug
definition: A substance used either in the prevention or facilitation of pregnancy.
has_related_synonym: reproductive control agent
has_related_synonym: reproductive control drugs
id: CHEBI:50689

abortifacient
type: Class
subclass of: reproductive control drug
definition: A chemical substance that interrupts pregnancy after implantation.
has_related_synonym: abortifacient agent
has_related_synonym: abortifacient agents
has_related_synonym: abortifacient drug
has_related_synonym: abortifacient drugs
has_related_synonym: abortifacients
id: CHEBI:50691

minocycline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: Escherichia coli metabolite
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
database_cross_reference: Beilstein:3077644
database_cross_reference: CAS:10118-90-8
database_cross_reference: DrugBank:DB01017
database_cross_reference: Drug_Central:1813
database_cross_reference: LIPID_MAPS_instance:LMPK07000002
database_cross_reference: PMID:28709717
database_cross_reference: PMID:31630007
database_cross_reference: PMID:31719236
database_cross_reference: PMID:31733348
database_cross_reference: Reaxys:3077644
has_exact_synonym: (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
has_exact_synonym: Minocycline
has_related_synonym: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
has_related_synonym: 7-Dimethylamino-6-demethyl-6-deoxytetracycline
has_related_synonym: minociclina
has_related_synonym: minociclinum
has_related_synonym: minocycline
has_related_synonym: minomycin
id: CHEBI:50694

Beilstein
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: Beilstein:3077644

ChemIDplus
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: CAS:10118-90-8

DrugCentral
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: Drug_Central:1813

LIPID MAPS
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMPK07000002

Europe PMC
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: PMID:28709717

Europe PMC
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: PMID:31630007

Europe PMC
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: PMID:31719236

Europe PMC
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: PMID:31733348

Reaxys
type: Axiom
annotated source: minocycline
annotated property: database_cross_reference
annotated target: Reaxys:3077644

estrogen receptor modulator
type: Class
subclass of: drug
definition: A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.
id: CHEBI:50739

cyproterone acetate
type: Class
subclass of: organic molecular entity
formula: C24H29ClO4
database_cross_reference: CAS:427-51-0
database_cross_reference: Wikipedia:Cyproterone_Acetate
has_exact_synonym: 6-chloro-3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-dien-17-yl acetate
has_exact_synonym: CPA

progestogen
type: Class
subclass of: sex hormone
definition: A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.
has_related_synonym: gestagen
has_related_synonym: gestagens
has_related_synonym: progestagen
has_related_synonym: progestagens
has_related_synonym: progestogens
id: CHEBI:50745

antipsoriatic
type: Class
subclass of: dermatologic drug
definition: A drug used to treat psoriasis.
has_related_synonym: antipsoriatic agent
has_related_synonym: antipsoriatic drug
id: CHEBI:50748

EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
type: Class
subclass of: topoisomerase inhibitor
definition: A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
has_related_synonym: DNA gyrase inhibitor
has_related_synonym: DNA gyrase inhibitors
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) inhibitor
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) inhibitors
has_related_synonym: DNA topoisomerase II inhibitor
has_related_synonym: DNA topoisomerase II inhibitors
has_related_synonym: EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor
has_related_synonym: EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors
has_related_synonym: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors
has_related_synonym: EC 5.99.1.3 inhibitor
has_related_synonym: EC 5.99.1.3 inhibitors
has_related_synonym: inhibitor of type II topoisomerase
has_related_synonym: inhibitors of type II topoisomerase
has_related_synonym: topoisomerase II inhibitor
has_related_synonym: topoisomerase II inhibitors
has_related_synonym: topoisomerase-II inhibitor
has_related_synonym: topoisomerase-II inhibitors
has_related_synonym: type II DNA topoisomerase inhibitor
has_related_synonym: type II DNA topoisomerase inhibitors
id: CHEBI:50750

anti-estrogen
type: Class
subclass of: drug
definition: A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
has_related_synonym: anti-estrogenic agent
has_related_synonym: anti-estrogenic drug
has_related_synonym: anti-oestrogen
has_related_synonym: anti-oestrogenic agent
has_related_synonym: anti-oestrogenic drug
has_related_synonym: antiestrogen
has_related_synonym: antiestrogenic agent
has_related_synonym: antiestrogenic drug
has_related_synonym: antioestrogen
has_related_synonym: antioestrogenic agent
has_related_synonym: antioestrogenic drug
id: CHEBI:50751

etonogestrel
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: contraceptive drug
subclass of: Restriction
  on property: has role
  some values from: female contraceptive drug
subclass of: Restriction
  on property: has role
  some values from: progestin
database_cross_reference: Beilstein:4237530
database_cross_reference: CAS:54048-10-1
database_cross_reference: DrugBank:DB00294
database_cross_reference: Drug_Central:1110
has_exact_synonym: 17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
has_related_synonym: 3-Ketodesogestrel
has_related_synonym: 3-Oxodesogestrel
has_related_synonym: Implanon
has_related_synonym: etonogestrel
has_related_synonym: etonogestrelum
id: CHEBI:50777

Beilstein
type: Axiom
annotated source: etonogestrel
annotated property: database_cross_reference
annotated target: Beilstein:4237530

ChemIDplus
type: Axiom
annotated source: etonogestrel
annotated property: database_cross_reference
annotated target: CAS:54048-10-1

DrugCentral
type: Axiom
annotated source: etonogestrel
annotated property: database_cross_reference
annotated target: Drug_Central:1110

EC 1.14.14.14 (aromatase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
definition: An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC 1.14.14.14) and so reduces production of estrogenic steroid hormones.
has_related_synonym: EC 1.14.14.14 (aromatase) inhibitors
has_related_synonym: EC 1.14.14.14 inhibitor
has_related_synonym: EC 1.14.14.14 inhibitors
has_related_synonym: aromatase (EC 1.14.14.14) inhibitor
has_related_synonym: aromatase (EC 1.14.14.14) inhibitors
has_related_synonym: aromatase inhibitor
has_related_synonym: aromatase inhibitors
has_related_synonym: estrogen synthase inhibitor
has_related_synonym: estrogen synthase inhibitors
has_related_synonym: estrogen synthetase inhibitor
has_related_synonym: estrogen synthetase inhibitors
has_related_synonym: oestrogen synthase inhibitor
has_related_synonym: oestrogen synthase inhibitors
has_related_synonym: oestrogen synthetase inhibitor
has_related_synonym: oestrogen synthetase inhibitors
id: CHEBI:50790

estrogen receptor antagonist
type: Class
subclass of: antagonist
definition: An antagonist at the estrogen receptor.
has_related_synonym: estrogen receptor antagonists
id: CHEBI:50792

estrogen antagonist
type: Class
subclass of: hormone antagonist
definition: A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
has_related_synonym: oestrogen antagonist
id: CHEBI:50837

immunomodulator
type: Class
subclass of: drug
subclass of: biological role
definition: Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
has_related_synonym: Biomodulator
has_related_synonym: Immune factor
has_related_synonym: Immunologic factor
has_related_synonym: Immunological factor
has_related_synonym: immunomodulators
id: CHEBI:50846

anti-allergic agent
type: Class
subclass of: drug
definition: A drug used to treat allergic reactions.
has_related_synonym: anti-allergic drug

bexarotene
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:153559-49-0
database_cross_reference: DrugBank:DB00307
database_cross_reference: Drug_Central:361
has_exact_synonym: 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
has_related_synonym: bexarotene
has_related_synonym: bexaroteno
has_related_synonym: bexarotenum
has_related_synonym: p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
id: CHEBI:50859

ChemIDplus
type: Axiom
annotated source: bexarotene
annotated property: database_cross_reference
annotated target: CAS:153559-49-0

DrugCentral
type: Axiom
annotated source: bexarotene
annotated property: database_cross_reference
annotated target: Drug_Central:361

organic molecular entity
type: Class
subclass of: chemical entity
definition: Any molecular entity that contains carbon.
has_exact_synonym: organic compounds
has_exact_synonym: organic entity

insulin-sensitizing drug
type: Class
subclass of: agonist
definition: An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).

genotoxin
type: Class
subclass of: aetiopathogenetic role
subclass of: TXPO_0000038
definition: A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
database_cross_reference: Wikipedia:Genotoxicity
has_related_synonym: genotoxic agent
has_related_synonym: genotoxic agents
has_related_synonym: genotoxins
id: CHEBI:50902

carcinogenic agent
type: Class
subclass of: aetiopathogenetic role
definition: A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
has_related_synonym: agente carcinogeno
has_related_synonym: cancerigene
has_related_synonym: cancerogene
has_related_synonym: carcinogen
has_related_synonym: carcinogene
has_related_synonym: carcinogenic agents
has_related_synonym: carcinogeno
has_related_synonym: carcinogens
id: CHEBI:50903

allergen
type: Class
subclass of: aetiopathogenetic role
definition: A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
definition: A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
database_cross_reference: Wikipedia:Allergen
has_related_synonym: alergeno
has_related_synonym: allergene
has_related_synonym: allergenic agent
id: CHEBI:50904

teratogenic agent
type: Class
subclass of: aetiopathogenetic role
definition: A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
has_related_synonym: agent teratogene
has_related_synonym: teratogen
has_related_synonym: teratogeno
id: CHEBI:50905

hepatotoxic agent
type: Class
subclass of: aetiopathogenetic role
subclass of: TXPO_0000038
definition: A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
definition: A role played by an entity exihibiting itself through the ability to induce damage to the liver in animals.
has_related_synonym: agente hepatotoxico
has_related_synonym: hepatotoxic agents
has_related_synonym: hepatotoxicant
has_related_synonym: hepatotoxicants
has_related_synonym: hepatotoxin
has_related_synonym: hepatotoxins
has_related_synonym: hepatoxic agent
has_related_synonym: hepatoxicant
id: CHEBI:50908

cardiotoxic agent
type: Class
subclass of: TXPO_0000038
definition: A role played by aan entity exihibiting itself through the ability to induce damage to the heart and cardiomyocytes.

sorafenib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: tyrosine kinase inhibitor
subclass of: Restriction
  on property: has role
  some values from: angiogenesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
database_cross_reference: CAS:284461-73-0
database_cross_reference: DrugBank:DB00398
database_cross_reference: Drug_Central:2459
database_cross_reference: LINCS:LSM-1008
has_related_synonym: N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
has_related_synonym: sorafenib
has_related_synonym: sorafenibum
id: CHEBI:50924

ChemIDplus
type: Axiom
annotated source: sorafenib
annotated property: database_cross_reference
annotated target: CAS:284461-73-0

DrugCentral
type: Axiom
annotated source: sorafenib
annotated property: database_cross_reference
annotated target: Drug_Central:2459

EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
type: Class
subclass of: enzyme inhibitor
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
has_related_synonym: A-kinase inhibitor
has_related_synonym: A-kinase inhibitors
has_related_synonym: AP50 kinase inhibitor
has_related_synonym: AP50 kinase inhibitors
has_related_synonym: ATP-protein transphosphorylase inhibitor
has_related_synonym: ATP-protein transphosphorylase inhibitors
has_related_synonym: ATP:protein phosphotransferase (non-specific) inhibitor
has_related_synonym: ATP:protein phosphotransferase (non-specific) inhibitors
has_related_synonym: BR serine/threonine-protein kinase 2 inhibitor
has_related_synonym: BR serine/threonine-protein kinase 2 inhibitors
has_related_synonym: CK-2 inhibitor
has_related_synonym: CK-2 inhibitors
has_related_synonym: CKI inhibitor
has_related_synonym: CKI inhibitors
has_related_synonym: CKII inhibitor
has_related_synonym: CKII inhibitors
has_related_synonym: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors
has_related_synonym: EC 2.7.11.1 inhibitor
has_related_synonym: EC 2.7.11.1 inhibitors
has_related_synonym: HIPK2 inhibitor
has_related_synonym: HIPK2 inhibitors
has_related_synonym: Hpr kinase inhibitor
has_related_synonym: Hpr kinase inhibitors
has_related_synonym: M phase-specific cdc2 kinase inhibitor
has_related_synonym: M phase-specific cdc2 kinase inhibitors
has_related_synonym: MKNK2 inhibitor
has_related_synonym: MKNK2 inhibitors
has_related_synonym: PAK-1 inhibitor
has_related_synonym: PAK-1 inhibitors
has_related_synonym: PAK1 inhibitor
has_related_synonym: PAK1 inhibitors
has_related_synonym: PKA inhibitor
has_related_synonym: PKA inhibitors
has_related_synonym: Prp4 protein kinase inhibitor
has_related_synonym: Prp4 protein kinase inhibitors
has_related_synonym: Raf kinase inhibitor
has_related_synonym: Raf kinase inhibitors
has_related_synonym: Raf-1 inhibitor
has_related_synonym: Raf-1 inhibitors
has_related_synonym: STK32 inhibitor
has_related_synonym: STK32 inhibitors
has_related_synonym: T-antigen kinase inhibitor
has_related_synonym: T-antigen kinase inhibitors
has_related_synonym: WEE1Hu inhibitor
has_related_synonym: WEE1Hu inhibitors
has_related_synonym: Wee 1-like kinase inhibitor
has_related_synonym: Wee 1-like kinase inhibitors
has_related_synonym: Wee-kinase inhibitor
has_related_synonym: Wee-kinase inhibitors
has_related_synonym: betaIIPKC inhibitor
has_related_synonym: betaIIPKC inhibitors
has_related_synonym: cAMP-dependent protein kinase A inhibitor
has_related_synonym: cAMP-dependent protein kinase A inhibitors
has_related_synonym: cAMP-dependent protein kinase inhibitor
has_related_synonym: cAMP-dependent protein kinase inhibitors
has_related_synonym: cGMP-dependent protein kinase inhibitor
has_related_synonym: cGMP-dependent protein kinase inhibitors
has_related_synonym: calcium-dependent protein kinase C inhibitor
has_related_synonym: calcium-dependent protein kinase C inhibitors
has_related_synonym: calcium/phospholipid-dependent protein kinase inhibitor
has_related_synonym: calcium/phospholipid-dependent protein kinase inhibitors
has_related_synonym: casein kinase (phosphorylating) inhibitor
has_related_synonym: casein kinase (phosphorylating) inhibitors
has_related_synonym: casein kinase 2 inhibitor
has_related_synonym: casein kinase 2 inhibitors
has_related_synonym: casein kinase I inhibitor
has_related_synonym: casein kinase I inhibitors
has_related_synonym: casein kinase II inhibitor
has_related_synonym: casein kinase II inhibitors
has_related_synonym: casein kinase inhibitor
has_related_synonym: casein kinase inhibitors
has_related_synonym: cyclic AMP-dependent protein kinase A inhibitor
has_related_synonym: cyclic AMP-dependent protein kinase A inhibitors
has_related_synonym: cyclic AMP-dependent protein kinase inhibitor
has_related_synonym: cyclic AMP-dependent protein kinase inhibitors
has_related_synonym: cyclic monophosphate-dependent protein kinase inhibitor

angiogenesis modulating agent
type: Class
subclass of: drug
definition: An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
id: CHEBI:50926

serotonin uptake inhibitor
type: Class
subclass of: serotonergic drug
definition: A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
has_related_synonym: SSRI
has_related_synonym: serotonin reuptake inhibitor
id: CHEBI:50949

unsaturated fatty acyl-CoA
type: Class
subclass of: fatty acyl-CoA
definition: A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any unsaturated fatty acid.
database_cross_reference: PMID:13152086

dopamine uptake inhibitor
type: Class
subclass of: dopaminergic agent
definition: A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
has_related_synonym: DARI
has_related_synonym: DRI
has_related_synonym: dopamine reuptake inhibitor
has_related_synonym: dopamine reuptake inhibitors
has_related_synonym: dopamine uptake inhibitors
id: CHEBI:51039

hormone receptor modulator
type: Class
subclass of: drug
subclass of: receptor modulator
definition: A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
has_related_synonym: hormone receptor modulators
id: CHEBI:51061

chemical role
type: Class
subclass of: role
definition: A role played by the molecular entity or part thereof within a chemical context.
id: CHEBI:51086

fluoxymesterone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: anabolic agent
database_cross_reference: Beilstein:2008796
database_cross_reference: CAS:76-43-7
database_cross_reference: DrugBank:DB01185
database_cross_reference: Drug_Central:1210
database_cross_reference: LIPID_MAPS_instance:LMST02020025
has_exact_synonym: 9-fluoro-11beta,17beta-dihydroxy-17alpha-methylandrost-4-en-3-one
has_related_synonym: 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one
has_related_synonym: 17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone
has_related_synonym: 9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one
has_related_synonym: 9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone
has_related_synonym: Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-
has_related_synonym: fluoximesterona
has_related_synonym: fluoxymesterone
has_related_synonym: fluoxymesteronum
id: CHEBI:5120

Beilstein
type: Axiom
annotated source: fluoxymesterone
annotated property: database_cross_reference
annotated target: Beilstein:2008796

ChemIDplus
type: Axiom
annotated source: fluoxymesterone
annotated property: database_cross_reference
annotated target: CAS:76-43-7

DrugCentral
type: Axiom
annotated source: fluoxymesterone
annotated property: database_cross_reference
annotated target: Drug_Central:1210

LIPID MAPS
type: Axiom
annotated source: fluoxymesterone
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMST02020025

flutamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: androgen antagonist
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:2157663
database_cross_reference: CAS:13311-84-7
database_cross_reference: DrugBank:DB00499
database_cross_reference: Drug_Central:1223
database_cross_reference: LINCS:LSM-2621
has_exact_synonym: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
has_exact_synonym: Flutamide
has_related_synonym: 4'-nitro-3'-trifluoromethylisobutyranilide
has_related_synonym: Eulexin
has_related_synonym: Niftolide
has_related_synonym: alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-propionotoluidide
has_related_synonym: flutamida
has_related_synonym: flutamide
has_related_synonym: flutamidum
has_related_synonym: niftolid
id: CHEBI:5132

ChemIDplus
type: Axiom
annotated source: flutamide
annotated property: database_cross_reference
annotated target: Beilstein:2157663

ChemIDplus
type: Axiom
annotated source: flutamide
annotated property: database_cross_reference
annotated target: CAS:13311-84-7

DrugCentral
type: Axiom
annotated source: flutamide
annotated property: database_cross_reference
annotated target: Drug_Central:1223

muscle relaxant
type: Class
subclass of: neuromuscular agent
definition: A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
has_related_synonym: muscle relaxants
id: CHEBI:51371

neuromuscular agent
type: Class
subclass of: drug
definition: A drug used for its actions on skeletal muscle.
id: CHEBI:51372

GABA agent
type: Class
subclass of: neurotransmitter agent
definition: A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems.
id: CHEBI:51374

bosentan
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antihypertensive agent
subclass of: Restriction
  on property: has role
  some values from: endothelin receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: ATC:C02KX01
database_cross_reference: CAS:147536-97-8
database_cross_reference: DrugBank:DB00559
database_cross_reference: Drug_Central:392
database_cross_reference: LINCS:LSM-5825
database_cross_reference: Wikipedia:Bosentan
has_exact_synonym: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
has_related_synonym: 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
has_related_synonym: bosentan
has_related_synonym: bosentanum
has_related_synonym: p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
id: CHEBI:51450

ChemIDplus
type: Axiom
annotated source: bosentan
annotated property: database_cross_reference
annotated target: CAS:147536-97-8

DrugCentral
type: Axiom
annotated source: bosentan
annotated property: database_cross_reference
annotated target: Drug_Central:392

endothelin receptor antagonist
type: Class
subclass of: hormone antagonist
definition: A hormone antagonist that blocks endothelin receptors.
has_related_synonym: ERA
id: CHEBI:51451

Fosphenytoin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:93390-81-9
database_cross_reference: Drug_Central:1247
has_exact_synonym: Fosphenytoin
has_related_synonym: cerebyx
has_related_synonym: fosphenytoin sodium
has_related_synonym: fosphenytoin sodium hydrate
id: CHEBI:5165

DrugCentral
type: Axiom
annotated source: Fosphenytoin
annotated property: database_cross_reference
annotated target: Drug_Central:1247

biochemical role
type: Class
subclass of: biological role
definition: A biological role played by the molecular entity or part thereof within a biochemical context.
id: CHEBI:52206

biophysical role
type: Class
subclass of: biological role
id: CHEBI:52208

aetiopathogenetic role
type: Class
subclass of: biological role
definition: A role played by the molecular entity or part thereof which causes the development of a pathological process.
has_related_synonym: etiopathogenetic agent
has_related_synonym: etiopathogenetic role
id: CHEBI:52209

pharmacological role
type: Class
subclass of: role
subclass of: biological role
definition: A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
id: CHEBI:52210

ligand
type: Class
subclass of: chemical role
definition: Any molecule or ion capable of binding to a central metal atom to form coordination complexes.
has_related_synonym: ligands
id: CHEBI:52214

pharmaceutical
type: Class
subclass of: role
definition: Any substance introduced into a living organism with therapeutic or diagnostic purpose.
has_related_synonym: farmaco
has_related_synonym: medicament
has_related_synonym: pharmaceuticals
id: CHEBI:52217

mitogen
type: Class
subclass of: biological role
definition: A chemical substance that encourages a cell to commence cell division, triggering mitosis.
has_related_synonym: mitogens
id: CHEBI:52290

EC 3.2.1.* (glycosidase) inhibitor
type: Class
subclass of: EC 3.2.* (glycosylase) inhibitor
definition: An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*).
has_related_synonym: EC 3.2.1.* (glycosidase) inhibitors
has_related_synonym: EC 3.2.1.* inhibitor
has_related_synonym: EC 3.2.1.* inhibitors
has_related_synonym: glycosidase (EC 3.2.1.*) inhibitor
has_related_synonym: glycosidase (EC 3.2.1.*) inhibitors
has_related_synonym: glycosidase inhibitor
has_related_synonym: glycosidase inhibitors
has_related_synonym: glycoside hydrolase inhibitors
id: CHEBI:52424

EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
type: Class
subclass of: anti-HIV-1 agent
subclass of: EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor
definition: An inhibitor of ribonuclease H (EC 3.1.26.13), an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid.
has_related_synonym: EC 3.1.26.13 (retroviral ribonuclease H) inhibitors
has_related_synonym: EC 3.1.26.13 inhibitor
has_related_synonym: EC 3.1.26.13 inhibitors
has_related_synonym: HIV RNase H inhibitor
has_related_synonym: HIV RNase H inhibitors
has_related_synonym: HIV-1 RNase H inhibitor
has_related_synonym: HIV-1 RNase H inhibitors
has_related_synonym: HIV-1 ribonuclease H inhibitor
has_related_synonym: HIV-1 ribonuclease H inhibitors
has_related_synonym: RT/RNase H inhibitor
has_related_synonym: RT/RNase H inhibitors
has_related_synonym: retroviral reverse transcriptase RNaseH inhibitor
has_related_synonym: retroviral reverse transcriptase RNaseH inhibitors
has_related_synonym: retroviral ribonuclease H (EC 3.1.26.13) inhibitor
has_related_synonym: retroviral ribonuclease H (EC 3.1.26.13) inhibitors
has_related_synonym: retroviral ribonuclease H inhibitor
id: CHEBI:52629

bortezomib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: antiprotozoal drug
subclass of: Restriction
  on property: has role
  some values from: protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: proteasome inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
formula: C19H25BN4O4
database_cross_reference: CAS:179324-69-7
database_cross_reference: DrugBank:DB00188
database_cross_reference: Drug_Central:391
database_cross_reference: LINCS:LSM-6281
database_cross_reference: PMID:18484921
database_cross_reference: PMID:18980173
database_cross_reference: PMID:21504411
database_cross_reference: PMID:21865767
database_cross_reference: Reaxys:8723817
database_cross_reference: Wikipedia:Bortezomib
has_exact_synonym: N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
has_exact_synonym: [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
has_related_synonym: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
has_related_synonym: PS 341
has_related_synonym: PS-341
has_related_synonym: Velcade
has_related_synonym: bortezomib
id: CHEBI:52717

ChemIDplus
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: CAS:179324-69-7

DrugCentral
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: Drug_Central:391

Europe PMC
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: PMID:18484921

Europe PMC
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: PMID:18980173

Europe PMC
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: PMID:21504411

Europe PMC
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: PMID:21865767

Reaxys
type: Axiom
annotated source: bortezomib
annotated property: database_cross_reference
annotated target: Reaxys:8723817

proteasome inhibitor
type: Class
subclass of: drug
definition: A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
has_related_synonym: proteasome inhibitors
id: CHEBI:52726

gemfibrozil
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antilipemic drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
formula: C15H22O3
smiles: Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
database_cross_reference: Beilstein:1881200
database_cross_reference: CAS:25812-30-0
database_cross_reference: DrugBank:DB01241
database_cross_reference: Drug_Central:1285
database_cross_reference: LINCS:LSM-2227
database_cross_reference: Wikipedia:Gemfibrozil
has_exact_synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
has_exact_synonym: Gemfibrozil
has_related_synonym: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
has_related_synonym: 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
has_related_synonym: 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
has_related_synonym: Gemfibrozilo
has_related_synonym: Lopid
has_related_synonym: gemfibrozil
has_related_synonym: gemfibrozilum
id: CHEBI:5296

Beilstein
type: Axiom
annotated source: gemfibrozil
annotated property: database_cross_reference
annotated target: Beilstein:1881200

ChemIDplus
type: Axiom
annotated source: gemfibrozil
annotated property: database_cross_reference
annotated target: CAS:25812-30-0

DrugCentral
type: Axiom
annotated source: gemfibrozil
annotated property: database_cross_reference
annotated target: Drug_Central:1285

topoisomerase IV inhibitor
type: Class
subclass of: topoisomerase inhibitor
definition: A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
has_related_synonym: topoisomerase IV inhibitors
id: CHEBI:53559

HIV-1 reverse transcriptase inhibitor
type: Class
subclass of: EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
subclass of: anti-HIV-1 agent
definition: An entity which inhibits the activity of HIV-1 reverse transcriptase.
has_related_synonym: HIV-1 reverse transcriptase inhibitors
has_related_synonym: reverse transcriptase inhibitor
has_related_synonym: reverse transcriptase inhibitors
id: CHEBI:53756

antispasmodic drug
type: Class
subclass of: muscle relaxant
definition: A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
has_related_synonym: antispasmodics
id: CHEBI:53784

glyburide
type: Class
subclass of: organic molecular entity
database_cross_reference: An urea that has formula C23H28ClN3O5S.
database_cross_reference: CASRN:10238-21-8
database_cross_reference: DrugBank:DB01016
database_cross_reference: InChIKeyZ:NNLBTZKUZBEKO-UHFFFAOYSA-N
database_cross_reference: Wikipedia:Glyburide
has_exact_synonym: glibenclamide

gastrointestinal drug
type: Class
subclass of: drug
definition: A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.
has_related_synonym: gastrointestinal agent
has_related_synonym: gastrointestinal agents
has_related_synonym: gastrointestinal drugs
id: CHEBI:55324

anidulafungin
type: Class
subclass of: organic molecular entity
definition: A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.
database_cross_reference: Beilstein:7408417
database_cross_reference: CAS:166663-25-8
database_cross_reference: DrugBank:DB00362
database_cross_reference: PMID:15482216
database_cross_reference: PMID:16770294
database_cross_reference: PMID:17316149
database_cross_reference: PMID:19072176
database_cross_reference: PMID:19113794
database_cross_reference: PMID:19877739
database_cross_reference: PMID:19877740
database_cross_reference: PMID:19877741
database_cross_reference: PMID:19877742
database_cross_reference: PMID:24165173
database_cross_reference: PMID:24955796
database_cross_reference: PMID:25473029
database_cross_reference: Reaxys:7408417
has_exact_synonym: N-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxamide
has_related_synonym: Eraxis
has_related_synonym: anidulafungin
has_related_synonym: anidulafungina
has_related_synonym: anidulafungine
has_related_synonym: anidulafunginum
id: CHEBI:55346

Beilstein
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: Beilstein:7408417

ChemIDplus
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: CAS:166663-25-8

DrugBank
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: CAS:166663-25-8

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:15482216

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:16770294

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:17316149

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19072176

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19113794

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19877739

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19877740

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19877741

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:19877742

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:24165173

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:24955796

Europe PMC
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: PMID:25473029

Reaxys
type: Axiom
annotated source: anidulafungin
annotated property: database_cross_reference
annotated target: Reaxys:7408417

malondialdehyde
type: Class
subclass of: TXPO_0004328
definition: A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.

atovaquone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antifungal agent
subclass of: Restriction
  on property: has role
  some values from: antimalarial
subclass of: Restriction
  on property: has role
  some values from: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor
definition: A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.
database_cross_reference: Beilstein:8076827
database_cross_reference: CAS:95233-18-4
database_cross_reference: DrugBank:DB01117
database_cross_reference: Drug_Central:258
database_cross_reference: PMID:10658902
database_cross_reference: PMID:11956677
database_cross_reference: PMID:12791689
database_cross_reference: PMID:14727190
database_cross_reference: PMID:15044733
database_cross_reference: PMID:15718226
database_cross_reference: PMID:21735454
database_cross_reference: PMID:23292347
has_exact_synonym: 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone
has_related_synonym: 2-(trans-4-(p-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone
has_related_synonym: Acuvel
has_related_synonym: Mepron
has_related_synonym: Wellvone
has_related_synonym: atovaquone
id: CHEBI:575568

Beilstein
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: Beilstein:8076827

ChemIDplus
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: CAS:95233-18-4

DrugBank
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: CAS:95233-18-4

DrugCentral
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: Drug_Central:258

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:10658902

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:11956677

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:12791689

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:14727190

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:15044733

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:15718226

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:21735454

Europe PMC
type: Axiom
annotated source: atovaquone
annotated property: database_cross_reference
annotated target: PMID:23292347

ibuprofen
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
formula: C13H18O2
smiles: CC(C)Cc1ccc(cc1)C(C)C(O)=O
database_cross_reference: CAS:15687-27-1
database_cross_reference: DrugBank:DB01050
has_exact_synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid

antigen
type: Class
subclass of: aetiopathogenetic role
database_cross_reference: Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).

EC 3.4.21.* (serine endopeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the activity of a serine endopeptidase (EC 3.4.21.*).
has_related_synonym: EC 3.4.21.* (serine endopeptidase) inhibitors
has_related_synonym: EC 3.4.21.* inhibitor
has_related_synonym: EC 3.4.21.* inhibitors
has_related_synonym: inhibitor of serine endopeptidase (EC 3.4.21.*)
has_related_synonym: inhibitor of serine endopeptidase (EC 3.4.21.*)s
has_related_synonym: serine endopeptidase inhibitor
has_related_synonym: serine endopeptidase inhibitors
id: CHEBI:5924

EC 1.14.13.132 (squalene monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132).
has_related_synonym: EC 1.14.13.132 (squalene monooxygenase) inhibitors
has_related_synonym: squalene 2,3-oxidocyclase inhibitor
has_related_synonym: squalene 2,3-oxidocyclase inhibitors
has_related_synonym: squalene epoxidase inhibitor
has_related_synonym: squalene epoxidase inhibitors
has_related_synonym: squalene hydroxylase inhibitor
has_related_synonym: squalene hydroxylase inhibitors
has_related_synonym: squalene monooxygenase (EC 1.14.13.132) inhibitor
has_related_synonym: squalene monooxygenase (EC 1.14.13.132) inhibitors
has_related_synonym: squalene monooxygenase inhibitor
has_related_synonym: squalene monooxygenase inhibitors
has_related_synonym: squalene oxydocyclase inhibitor
has_related_synonym: squalene oxydocyclase inhibitors
has_related_synonym: squalene-2,3-epoxidase inhibitor
has_related_synonym: squalene-2,3-epoxidase inhibitors
has_related_synonym: squalene-2,3-epoxide cyclase inhibitor
has_related_synonym: squalene-2,3-epoxide cyclase inhibitors
id: CHEBI:59285

Interferon alfa-2a
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:76543-88-9
has_exact_synonym: Interferon alfa-2a
has_related_synonym: Interferon alpha-2A
id: CHEBI:5937

Interferon beta-1b
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:145155-23-3
has_exact_synonym: Interferon beta-1b
id: CHEBI:5938

DNA synthesis inhibitor
type: Class
subclass of: pathway inhibitor
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: DNA biosynthetic process
definition: Any substance that inhibits the synthesis of DNA.
has_related_synonym: DNA synthesis inhibitors
id: CHEBI:59517

Iproniazid
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:54-92-2
database_cross_reference: Drug_Central:1480
database_cross_reference: LINCS:LSM-5940
has_exact_synonym: Iproniazid
has_related_synonym: euphozid
has_related_synonym: iprazid
has_related_synonym: iprazide
has_related_synonym: iproniazid phosphate
has_related_synonym: iproniazide
has_related_synonym: iproniazide phosphate
has_related_synonym: marsilid
id: CHEBI:5958

DrugCentral
type: Axiom
annotated source: Iproniazid
annotated property: database_cross_reference
annotated target: Drug_Central:1480

electrophilic reagent
type: Class
subclass of: acid
definition: A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner.
has_exact_synonym: electrophile
has_exact_synonym: electrophiles
has_exact_synonym: electrophilic reagents

nucleophilic reagent
type: Class
subclass of: base
definition: A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
has_exact_synonym: nucleophile

progestin
type: Class
subclass of: progestogen
definition: A synthetic progestogen.
has_related_synonym: progestins
id: CHEBI:59826

HIV fusion inhibitor
type: Class
subclass of: antiviral drug
subclass of: anti-HIV agent
definition: A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
database_cross_reference: PMID:22470838
has_related_synonym: HIV entry inhibitor
has_related_synonym: HIV entry inhibitors
has_related_synonym: HIV fusion inhibitors
id: CHEBI:59886

Europe PMC
type: Axiom
annotated source: HIV fusion inhibitor
annotated property: database_cross_reference
annotated target: PMID:22470838

EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
type: Class
subclass of: antiviral agent
subclass of: DNA polymerase inhibitor
definition: A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.
has_related_synonym: DNA nucleotidyltransferase (RNA-directed) inhibitor
has_related_synonym: DNA nucleotidyltransferase (RNA-directed) inhibitors
has_related_synonym: EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors
has_related_synonym: EC 2.7.7.49 inhibitor
has_related_synonym: EC 2.7.7.49 inhibitors
has_related_synonym: RNA revertase inhibitor
has_related_synonym: RNA revertase inhibitors
has_related_synonym: RNA-dependent DNA polymerase inhibitor
has_related_synonym: RNA-dependent DNA polymerase inhibitors
has_related_synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor
has_related_synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors
has_related_synonym: RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor
has_related_synonym: RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors
has_related_synonym: RNA-directed DNA polymerase inhibitor
has_related_synonym: RNA-directed DNA polymerase inhibitors
has_related_synonym: RNA-instructed DNA polymerase inhibitor
has_related_synonym: RNA-instructed DNA polymerase inhibitors
has_related_synonym: RT inhibitor
has_related_synonym: RT inhibitors
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors
has_related_synonym: reverse transcriptase inhibitor
has_related_synonym: reverse transcriptase inhibitors
has_related_synonym: revertase inhibitor
has_related_synonym: revertase inhibitors
has_related_synonym: telomerase inhibitor
has_related_synonym: telomerase inhibitors
id: CHEBI:59897

micafungin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy.
database_cross_reference: Beilstein:9610508
database_cross_reference: CAS:235114-32-6
database_cross_reference: DrugBank:DB01141
database_cross_reference: PMID:17194830
database_cross_reference: PMID:17307974
database_cross_reference: PMID:17325217
database_cross_reference: PMID:17325225
database_cross_reference: PMID:17420211
database_cross_reference: PMID:17785512
has_exact_synonym: 5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate
has_exact_synonym: 5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-(3R)-3-hydroxy-L-glutaminyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}
has_related_synonym: Mycamine
has_related_synonym: micafungin
id: CHEBI:600520

Beilstein
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: Beilstein:9610508

ChemIDplus
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: CAS:235114-32-6

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17194830

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17307974

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17325217

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17325225

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17420211

ChEMBL
type: Axiom
annotated source: micafungin
annotated property: database_cross_reference
annotated target: PMID:17785512

phosphatidylinositol trisphosphate
type: Class
subclass of: phosphatidylinositol phosphate
definition: A derivative of phosphatidylinositol in which the inositol ring is phosphorylated at three unspecified positions.

EC 3.4.* (hydrolases acting on peptide bond) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*).
has_related_synonym: EC 3.4.* (hydrolase acting on peptide bond) inhibitor
has_related_synonym: EC 3.4.* (hydrolase acting on peptide bonds) inhibitors
has_related_synonym: EC 3.4.* (hydrolases acting on peptide bond) inhibitors
has_related_synonym: EC 3.4.* (peptidase) inhibitor
has_related_synonym: EC 3.4.* (peptidase) inhibitors
has_related_synonym: EC 3.4.* inhibitor
has_related_synonym: EC 3.4.* inhibitors
has_related_synonym: inhibitor of hydrolases acting on peptide bond (EC 3.4.*)
has_related_synonym: inhibitors of hydrolases acting on peptide bond (EC 3.4.*)
has_related_synonym: peptidase inhibitors
has_related_synonym: protease inhibitor
has_related_synonym: protease inhibitors
id: CHEBI:60258

isoniazide
type: Class
subclass of: organic molecular entity
definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
formula: C6H7N3O
smiles: NNC(=O)c1ccncc1
database_cross_reference: CAS:54-85-3
database_cross_reference: DrugBank:DB00951
database_cross_reference: LINCS:LSM-6682
has_exact_synonym: pyridine-4-carbohydrazide

isotretinoin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: keratolytic drug
subclass of: Restriction
  on property: has role
  some values from: teratogenic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
database_cross_reference: Beilstein:1885770
database_cross_reference: CAS:4759-48-2
database_cross_reference: DrugBank:DB00982
database_cross_reference: Drug_Central:1508
database_cross_reference: LIPID_MAPS_instance:LMPR01090021
database_cross_reference: PMID:11606947
database_cross_reference: PMID:11866680
database_cross_reference: PMID:15304471
database_cross_reference: PMID:18077132
database_cross_reference: PMID:18788179
database_cross_reference: PMID:19568610
database_cross_reference: PMID:20482692
database_cross_reference: PMID:23676507
database_cross_reference: PMID:9807973
database_cross_reference: Reaxys:1885770
has_exact_synonym: (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
has_related_synonym: (7E,9E,11E,13Z)-retinoic acid
has_related_synonym: 13-RA
has_related_synonym: 13-cis-Vitamin A acid
has_related_synonym: 13-cis-retinoic acid
has_related_synonym: Accutane
has_related_synonym: Amnesteem
has_related_synonym: Claravis
has_related_synonym: Neovitamin A acid
has_related_synonym: cis-RA
has_related_synonym: isotretinoin
has_related_synonym: isotretinoina
has_related_synonym: isotretinoine
has_related_synonym: isotretinoino
has_related_synonym: isotretinoinum
id: CHEBI:6067

Beilstein
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: Beilstein:1885770

ChemIDplus
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: CAS:4759-48-2

DrugCentral
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: Drug_Central:1508

LIPID MAPS
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: LIPID_MAPS_instance:LMPR01090021

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:11606947

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:11866680

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:15304471

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:18077132

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:18788179

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:19568610

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:20482692

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:23676507

Europe PMC
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: PMID:9807973

Reaxys
type: Axiom
annotated source: isotretinoin
annotated property: database_cross_reference
annotated target: Reaxys:1885770

itraconazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: Hedgehog signaling pathway inhibitor
subclass of: Restriction
  on property: has role
  some values from: P450 inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
database_cross_reference: CAS:84625-61-6
database_cross_reference: DrugBank:DB01167
database_cross_reference: PMID:11219548
database_cross_reference: PMID:11403818
database_cross_reference: PMID:11422002
database_cross_reference: PMID:15521894
database_cross_reference: PMID:19025521
database_cross_reference: PMID:20400651
database_cross_reference: PMID:25326091
has_exact_synonym: 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
has_exact_synonym: Itraconazole
has_exact_synonym: itraconazole
has_related_synonym: Itrizole (TN)
has_related_synonym: Oriconazole
has_related_synonym: Sporanox (TN)
id: CHEBI:6076

ChemIDplus
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: CAS:84625-61-6

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:11219548

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:11403818

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:11422002

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:15521894

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:19025521

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:20400651

Europe PMC
type: Axiom
annotated source: itraconazole
annotated property: database_cross_reference
annotated target: PMID:25326091

excitatory amino acid antagonist
type: Class
subclass of: antagonist
definition: Any substance which inhibits the action of receptors for excitatory amino acids.
has_related_synonym: EAA receptor antagonist
has_related_synonym: EAA receptor antagonists
has_related_synonym: excitatory amino acid antagonists
has_related_synonym: excitatory amino acid receptor antagonist
has_related_synonym: excitatory amino acid receptor antagonists
id: CHEBI:60798

lysobisphosphatidic acid
type: Class
subclass of: lysophosphatidic acids
subclass of: Restriction
  on property: participates in
  all values from: TXPO_0000010
definition: A lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.
database_cross_reference: BMP is a negatively charged phospholipid found almost exclusively in late endosomes/lysosomes. BMP content is higher in alveolar macrophages (18% of total phospholipids) than in other cell types. BMP is a structural isomer of phosphatidylglycerol (PG) and is synthesized through a series of acylation and deacylation steps involving a transacylase. BMP its unusual sn-1;sn-1′ structural configuration (based on the phosphate-linked glycerol carbon), which is not observed in other phospholipids. This unusual configuration is thought to play a role in the resistance of BMP to many phospholipases, and its stability in late endosomes/lysosomes. BMP stimulates the degradation of glycosphingolipids in coordination with lipid binding proteins (saposins) in lysosomes. PMID:25795792
has_exact_synonym: BMP
has_exact_synonym: LBPA
has_related_synonym: bis(monoacylglycerol) hydrogen phosphate

Axiom
annotated source: lysobisphosphatidic acid
annotated property: subClassOf
annotated target: Restriction
  on property: participates in
  all values from: TXPO_0000010
database_cross_reference: PMID:22960355

tubulin modulator
type: Class
subclass of: pharmacological role
definition: Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
has_related_synonym: tubulin modulators
id: CHEBI:60832

nephrotoxin
type: Class
subclass of: poison
definition: A poison that interferes with the function of the kidneys.
has_related_synonym: nephrotoxins
id: CHEBI:61015

EC 3.5.1.98 (histone deacetylase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
has_related_synonym: EC 3.5.1.98 (histone deacetylase) inhibitors
has_related_synonym: EC 3.5.1.98 inhibitor
has_related_synonym: EC 3.5.1.98 inhibitors
has_related_synonym: HDAC inhibitor
has_related_synonym: HDAC inhibitors
has_related_synonym: HDACi
has_related_synonym: HDACis
has_related_synonym: HDI
has_related_synonym: HDIs
has_related_synonym: histone amidohydrolase inhibitor
has_related_synonym: histone amidohydrolase inhibitors
has_related_synonym: histone deacetylase (EC 3.5.1.98) inhibitor
has_related_synonym: histone deacetylase (EC 3.5.1.98) inhibitors
has_related_synonym: histone deacetylase inhibitor
has_related_synonym: histone deacetylase inhibitors
id: CHEBI:61115

fatty acid derivative
type: Class
subclass of: organic molecular entity
definition: Any organic molecular entity derived from a fatty acid.
has_exact_synonym: FA derivative

very long-chain fatty acyl-CoA
type: Class
subclass of: fatty acyl-CoA
definition: A fatty acyl-CoA in which the fatty acyl group has a chain length greater than C22.
has_exact_synonym: VLCFA-CoA

microtubule-destabilising agent
type: Class
subclass of: tubulin modulator
subclass of: antimitotic
definition: Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
database_cross_reference: PMID:17099073
has_related_synonym: microtubule destabilising agent
has_related_synonym: microtubule destabilising agents
has_related_synonym: microtubule destabilising role
has_related_synonym: microtubule destabilizing role
has_related_synonym: microtubule-destabilising agents
has_related_synonym: microtubule-destabilizing agent
has_related_synonym: microtubule-destabilizing agents
id: CHEBI:61951

Europe PMC
type: Axiom
annotated source: microtubule-destabilising agent
annotated property: database_cross_reference
annotated target: PMID:17099073

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
type: Class
subclass of: tyrosine kinase inhibitor
subclass of: EC 2.7.10.* (protein-tyrosine kinase) inhibitor
definition: An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
has_related_synonym: AATK inhibitor
has_related_synonym: AATYK inhibitor
has_related_synonym: AATYK2 inhibitor
has_related_synonym: AATYK3 inhibitor
has_related_synonym: ACH inhibitor
has_related_synonym: ALK inhibitor
has_related_synonym: ALK inhibitors
has_related_synonym: ARK inhibitor
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors
has_related_synonym: AXL inhibitor
has_related_synonym: BRT inhibitor
has_related_synonym: Bek inhibitor
has_related_synonym: Bfgfr inhibitor
has_related_synonym: Bsk inhibitor
has_related_synonym: C-FMS inhibitor
has_related_synonym: CAK inhibitor
has_related_synonym: CCK4 inhibitor
has_related_synonym: CD115 inhibitor
has_related_synonym: CD135 inhibitor
has_related_synonym: CDw135 inhibitor
has_related_synonym: CFD1 inhibitor
has_related_synonym: CKIT inhibitor
has_related_synonym: CSF1R inhibitor
has_related_synonym: Cek1 inhibitor
has_related_synonym: Cek10 inhibitor
has_related_synonym: Cek11 inhibitor
has_related_synonym: Cek2 inhibitor
has_related_synonym: Cek3 inhibitor
has_related_synonym: Cek5 inhibitor
has_related_synonym: Cek6 inhibitor
has_related_synonym: Cek7 inhibitor
has_related_synonym: DAlk inhibitor
has_related_synonym: DDR1 inhibitor
has_related_synonym: DDR2 inhibitor
has_related_synonym: DKFZp434C1418 inhibitor
has_related_synonym: DRT inhibitor
has_related_synonym: DTK inhibitor
has_related_synonym: Dek inhibitor
has_related_synonym: Drosophila Eph kinase inhibitor
has_related_synonym: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors
has_related_synonym: EC 2.7.10.1 inhibitor
has_related_synonym: EC 2.7.10.1 inhibitors
has_related_synonym: ECK inhibitor
has_related_synonym: EDDR1 inhibitor
has_related_synonym: EGFR inhibitor
has_related_synonym: EPH inhibitor
has_related_synonym: EPHA1 inhibitor
has_related_synonym: EPHA2 inhibitor
has_related_synonym: EPHA6 inhibitor
has_related_synonym: EPHA7 inhibitor
has_related_synonym: EPHA8 inhibitor
has_related_synonym: EPHB1 inhibitor
has_related_synonym: EPHB2 inhibitor
has_related_synonym: EPHB3 inhibitor
has_related_synonym: EPHB4 inhibitor
has_related_synonym: EPHT inhibitor
has_related_synonym: EPHT2 inhibitor
has_related_synonym: EPHT3 inhibitor
has_related_synonym: EPHX inhibitor
has_related_synonym: ERBB inhibitor
has_related_synonym: ERBB1 inhibitor
has_related_synonym: ERBB2 inhibitor
has_related_synonym: ERBB3 inhibitor
has_related_synonym: ERBB4 inhibitor
has_related_synonym: ERK inhibitor
has_related_synonym: Ebk inhibitor
has_related_synonym: Eek inhibitor
has_related_synonym: Ehk2 inhibitor
has_related_synonym: Ehk3 inhibitor
has_related_synonym: Elk inhibitor
has_related_synonym: EphB5 inhibitor
has_related_synonym: Eyk inhibitor
has_related_synonym: FGFR1 inhibitor
has_related_synonym: FGFR2 inhibitor
has_related_synonym: FGFR3 inhibitor

EC 1.2.3.1 (aldehyde oxidase) inhibitor
type: Class
subclass of: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
definition: An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
has_related_synonym: EC 1.2.3.1 (aldehyde oxidase) inhibitors
has_related_synonym: EC 1.2.3.1 inhibitor
has_related_synonym: EC 1.2.3.1 inhibitors
has_related_synonym: aldehyde oxidase (EC 1.2.3.1) inhibitor
has_related_synonym: aldehyde oxidase (EC 1.2.3.1) inhibitors
has_related_synonym: aldehyde oxidase inhibitor
has_related_synonym: aldehyde oxidase inhibitors
has_related_synonym: aldehyde:oxygen oxidoreductase inhibitor
has_related_synonym: aldehyde:oxygen oxidoreductase inhibitors
has_related_synonym: quinoline oxidase inhibitor
has_related_synonym: quinoline oxidase inhibitors
has_related_synonym: retinal oxidase inhibitor
has_related_synonym: retinal oxidase inhibitors
has_related_synonym: retinoic acid synthase inhibitor
has_related_synonym: retinoic acid synthase inhibitors
id: CHEBI:62872

EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of purine nucleoside phosphorylase (EC 2.4.2.1).
has_related_synonym: EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitors
has_related_synonym: EC 2.4.2.1 inhibitor
has_related_synonym: EC 2.4.2.1 inhibitors
has_related_synonym: PNPase inhibitor
has_related_synonym: PNPase inhibitors
has_related_synonym: PUNPI inhibitor
has_related_synonym: PUNPI inhibitors
has_related_synonym: PUNPII inhibitor
has_related_synonym: PUNPII inhibitors
has_related_synonym: inosine phosphorylase inhibitor
has_related_synonym: inosine phosphorylase inhibitors
has_related_synonym: inosine-guanosine phosphorylase inhibitor
has_related_synonym: inosine-guanosine phosphorylase inhibitors
has_related_synonym: nucleotide phosphatase inhibitor
has_related_synonym: nucleotide phosphatase inhibitors
has_related_synonym: purine deoxynucleoside phosphorylase inhibitor
has_related_synonym: purine deoxynucleoside phosphorylase inhibitors
has_related_synonym: purine deoxyribonucleoside phosphorylase inhibitor
has_related_synonym: purine deoxyribonucleoside phosphorylase inhibitors
has_related_synonym: purine nucleoside phosphorylase inhibitor
has_related_synonym: purine nucleoside phosphorylase inhibitors
has_related_synonym: purine ribonucleoside phosphorylase inhibitor
has_related_synonym: purine ribonucleoside phosphorylase inhibitors
has_related_synonym: purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitor
has_related_synonym: purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitors
has_related_synonym: purine-nucleoside phosphorylase inhibitor
has_related_synonym: purine-nucleoside phosphorylase inhibitors
has_related_synonym: purine-nucleoside:phosphate ribosyltransferase inhibitor
has_related_synonym: purine-nucleoside:phosphate ribosyltransferase inhibitors
id: CHEBI:63090

reducing agent
type: Class
subclass of: chemical role
definition: The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species.
has_related_synonym: Wikipedia:Reducing_agent
has_related_synonym: reducer
has_related_synonym: reductant

oxidising agent
type: Class
subclass of: chemical role
definition: A substance that removes electrons from another reactant in a redox reaction.
has_related_synonym: oxidant
has_related_synonym: oxidiser
has_related_synonym: oxidizer

labetalol
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: beta-adrenergic antagonist
subclass of: Restriction
  on property: has role
  some values from: antihypertensive agent
subclass of: Restriction
  on property: has role
  some values from: alpha-adrenergic antagonist
subclass of: Restriction
  on property: has role
  some values from: sympatholytic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure.
database_cross_reference: Beilstein:2948416
database_cross_reference: CAS:36894-69-6
database_cross_reference: DrugBank:DB00598
database_cross_reference: Drug_Central:1531
database_cross_reference: LINCS:LSM-1282
database_cross_reference: PMID:21908132
database_cross_reference: PMID:22300487
database_cross_reference: PMID:22528277
database_cross_reference: PMID:23055089
database_cross_reference: PMID:28166217
database_cross_reference: Reaxys:2948416
has_exact_synonym: 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
has_exact_synonym: Labetalol
has_related_synonym: 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
has_related_synonym: 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
has_related_synonym: kabetalol
has_related_synonym: labetalol
has_related_synonym: labetalolum
id: CHEBI:6343

Beilstein
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: Beilstein:2948416

ChemIDplus
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: CAS:36894-69-6

DrugCentral
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: Drug_Central:1531

Europe PMC
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: PMID:21908132

Europe PMC
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: PMID:22300487

Europe PMC
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: PMID:22528277

Europe PMC
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: PMID:23055089

Europe PMC
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: PMID:28166217

Reaxys
type: Axiom
annotated source: labetalol
annotated property: database_cross_reference
annotated target: Reaxys:2948416

stavudine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral agent
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase
formula: C10H12N2O4
database_cross_reference: CAS:3056-17-5
database_cross_reference: DrugBank:DB00649
database_cross_reference: Drug_Central:2478
database_cross_reference: LINCS:LSM-5983
database_cross_reference: Reaxys:618327
database_cross_reference: Wikipedia:Stavudine
has_exact_synonym: 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
has_exact_synonym: Stavudine
has_exact_synonym: d4T
has_related_synonym: 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine
has_related_synonym: 2',3'-Didehydro-3'-deoxythimidine
has_related_synonym: 3'-Deoxy-2'-thymidinene
has_related_synonym: STV
has_related_synonym: Sanilvudine
has_related_synonym: d4T
has_related_synonym: estavudina
has_related_synonym: stavudine
has_related_synonym: stavudinum
id: CHEBI:63581

ChemIDplus
type: Axiom
annotated source: stavudine
annotated property: database_cross_reference
annotated target: CAS:3056-17-5

DrugCentral
type: Axiom
annotated source: stavudine
annotated property: database_cross_reference
annotated target: Drug_Central:2478

Reaxys
type: Axiom
annotated source: stavudine
annotated property: database_cross_reference
annotated target: Reaxys:618327

etravirine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral agent
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities
database_cross_reference: CAS:269055-15-4
database_cross_reference: DrugBank:DB06414
database_cross_reference: PMID:21114458
database_cross_reference: PMID:21142266
database_cross_reference: PMID:21173188
database_cross_reference: PMID:21189339
database_cross_reference: PMID:21383098
database_cross_reference: PMID:21464253
database_cross_reference: PMID:21557669
database_cross_reference: PMID:21600016
database_cross_reference: PMID:21637112
database_cross_reference: PMID:21881478
database_cross_reference: PMID:22011983
database_cross_reference: PMID:22089378
database_cross_reference: PMID:22190606
database_cross_reference: PMID:25017682
database_cross_reference: Reaxys:8945855
has_exact_synonym: 4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile
has_related_synonym: etravirine
id: CHEBI:63589

ChemIDplus
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: CAS:269055-15-4

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21114458

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21142266

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21173188

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21189339

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21383098

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21464253

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21557669

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21600016

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21637112

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:21881478

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:22011983

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:22089378

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:22190606

Europe PMC
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: PMID:25017682

Reaxys
type: Axiom
annotated source: etravirine
annotated property: database_cross_reference
annotated target: Reaxys:8945855

levofloxacin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: topoisomerase IV inhibitor
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase
database_cross_reference: CAS:100986-85-4
database_cross_reference: DrugBank:DB01137
database_cross_reference: Drug_Central:1569
database_cross_reference: LINCS:LSM-5270
database_cross_reference: PMID:21075586
database_cross_reference: PMID:21965436
database_cross_reference: PMID:21974858
database_cross_reference: PMID:22088660
database_cross_reference: PMID:22221614
database_cross_reference: Reaxys:5385660
has_exact_synonym: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
has_related_synonym: (-)-Ofloxacin
has_related_synonym: (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
has_related_synonym: (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid
has_related_synonym: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
has_related_synonym: (S)-Ofloxacin
has_related_synonym: L-Ofloxacin
has_related_synonym: Ofloxacin S-(-)-form
has_related_synonym: levofloxacin
has_related_synonym: levofloxacine
has_related_synonym: levofloxacino
has_related_synonym: levofloxacinum
id: CHEBI:63598

ChemIDplus
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: CAS:100986-85-4

DrugCentral
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: Drug_Central:1569

Europe PMC
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: PMID:21075586

Europe PMC
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: PMID:21965436

Europe PMC
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: PMID:21974858

Europe PMC
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: PMID:22088660

Europe PMC
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: PMID:22221614

Reaxys
type: Axiom
annotated source: levofloxacin
annotated property: database_cross_reference
annotated target: Reaxys:5385660

maraviroc
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV fusion inhibitor
subclass of: Restriction
  on property: has role
  some values from: chemokine receptor 5 antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
database_cross_reference: CAS:376348-65-1
database_cross_reference: DrugBank:DB04835
database_cross_reference: PMID:21134404
database_cross_reference: PMID:21383098
database_cross_reference: PMID:21393136
database_cross_reference: PMID:21505306
database_cross_reference: PMID:21595497
database_cross_reference: PMID:21692669
database_cross_reference: PMID:21987241
database_cross_reference: PMID:22017448
database_cross_reference: PMID:22034870
database_cross_reference: PMID:22064539
database_cross_reference: PMID:22090117
database_cross_reference: PMID:22118500
database_cross_reference: PMID:22174038
database_cross_reference: PMID:22236118
database_cross_reference: PMID:22247337
database_cross_reference: PMID:24419064
database_cross_reference: PMID:24651825
database_cross_reference: PMID:24652492
database_cross_reference: PMID:25017682
database_cross_reference: Reaxys:10131963
has_exact_synonym: 4,4-difluoro-N-{(1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
has_related_synonym: maraviroc
has_related_synonym: maravirocum
id: CHEBI:63608

ChemIDplus
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: CAS:376348-65-1

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21134404

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21383098

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21393136

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21505306

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21595497

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21692669

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:21987241

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22017448

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22034870

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22064539

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22090117

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22118500

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22174038

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22236118

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:22247337

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:24419064

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:24651825

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:24652492

Europe PMC
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: PMID:25017682

Reaxys
type: Axiom
annotated source: maraviroc
annotated property: database_cross_reference
annotated target: Reaxys:10131963

nevirapine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has role
  some values from: HIV-1 reverse transcriptase inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
database_cross_reference: CAS:129618-40-2
database_cross_reference: DrugBank:DB00238
database_cross_reference: LINCS:LSM-5336
database_cross_reference: PMID:1712395
database_cross_reference: PMID:25017682
database_cross_reference: PMID:28782122
database_cross_reference: PMID:28786740
database_cross_reference: PMID:28819312
database_cross_reference: PMID:28827836
database_cross_reference: PMID:28835669
database_cross_reference: Reaxys:4757598
has_exact_synonym: 11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
has_exact_synonym: Nevirapine
has_related_synonym: 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
has_related_synonym: NEV
has_related_synonym: NVP
has_related_synonym: Viramune
has_related_synonym: nevirapine
id: CHEBI:63613

ChemIDplus
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: CAS:129618-40-2

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:1712395

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:25017682

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:28782122

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:28786740

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:28819312

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:28827836

Europe PMC
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: PMID:28835669

Reaxys
type: Axiom
annotated source: nevirapine
annotated property: database_cross_reference
annotated target: Reaxys:4757598

tipranavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: antiviral drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.
database_cross_reference: CAS:174484-41-4
database_cross_reference: DrugBank:DB00932
database_cross_reference: PMID:17620375
database_cross_reference: PMID:20368406
database_cross_reference: PMID:21041916
database_cross_reference: PMID:21571982
database_cross_reference: PMID:21576452
database_cross_reference: PMID:21825300
database_cross_reference: PMID:21871444
database_cross_reference: PMID:22007990
database_cross_reference: PMID:22096044
database_cross_reference: PMID:22258921
database_cross_reference: PMID:25017682
database_cross_reference: Reaxys:7698323
has_exact_synonym: N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
has_related_synonym: 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
has_related_synonym: tipranavir
id: CHEBI:63628

ChemIDplus
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: CAS:174484-41-4

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:17620375

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:20368406

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:21041916

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:21571982

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:21576452

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:21825300

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:21871444

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:22007990

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:22096044

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:22258921

Europe PMC
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: PMID:25017682

Reaxys
type: Axiom
annotated source: tipranavir
annotated property: database_cross_reference
annotated target: Reaxys:7698323

tizanidine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: alpha-adrenergic agonist
subclass of: Restriction
  on property: has role
  some values from: muscle relaxant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
database_cross_reference: Beilstein:618691
database_cross_reference: CAS:51322-75-9
database_cross_reference: DrugBank:DB00697
database_cross_reference: Drug_Central:2683
database_cross_reference: LINCS:LSM-5242
database_cross_reference: PMID:21317414
database_cross_reference: PMID:21733633
database_cross_reference: PMID:21982341
database_cross_reference: PMID:22196407
database_cross_reference: PMID:22223284
database_cross_reference: Reaxys:618691
has_exact_synonym: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
has_exact_synonym: Tizanidine
has_related_synonym: 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
has_related_synonym: tizanidina
has_related_synonym: tizanidine
has_related_synonym: tizanidinum
id: CHEBI:63629

ChemIDplus
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: Beilstein:618691

ChemIDplus
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: CAS:51322-75-9

DrugCentral
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: Drug_Central:2683

Europe PMC
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: PMID:21317414

Europe PMC
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: PMID:21733633

Europe PMC
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: PMID:21982341

Europe PMC
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: PMID:22196407

Europe PMC
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: PMID:22223284

Reaxys
type: Axiom
annotated source: tizanidine
annotated property: database_cross_reference
annotated target: Reaxys:618691

tolcapone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: antiparkinson drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.
database_cross_reference: DrugBank:DB00323
database_cross_reference: Drug_Central:2697
database_cross_reference: LINCS:LSM-5282
database_cross_reference: PMID:20381177
database_cross_reference: PMID:20502133
database_cross_reference: PMID:21521027
database_cross_reference: PMID:22136163
database_cross_reference: Reaxys:8151577
has_exact_synonym: (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
has_related_synonym: 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
has_related_synonym: 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone
has_related_synonym: 3,4-dihydroxy-5-nitro-4'-methylbenzophenone
has_related_synonym: 4'-methyl-3,4-dihydroxy-5-nitrobenzophenone
has_related_synonym: tolcapone
id: CHEBI:63630

DrugCentral
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: Drug_Central:2697

Europe PMC
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: PMID:20381177

Europe PMC
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: PMID:20502133

Europe PMC
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: PMID:21521027

Europe PMC
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: PMID:22136163

Reaxys
type: Axiom
annotated source: tolcapone
annotated property: database_cross_reference
annotated target: Reaxys:8151577

lamotrigine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: antimanic drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: calcium channel blocker
subclass of: Restriction
  on property: has role
  some values from: excitatory amino acid antagonist
subclass of: Restriction
  on property: has role
  some values from: EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
database_cross_reference: CAS:84057-84-1
database_cross_reference: DrugBank:DB00555
database_cross_reference: Drug_Central:1540
database_cross_reference: LINCS:LSM-4104
database_cross_reference: PMID:20825390
database_cross_reference: PMID:21242744
database_cross_reference: Reaxys:7589268
has_exact_synonym: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
has_related_synonym: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
has_related_synonym: Lamictal
has_related_synonym: lamotrigina
has_related_synonym: lamotrigine
has_related_synonym: lamotriginum
id: CHEBI:6367

ChemIDplus
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: CAS:84057-84-1

NIST Chemistry WebBook
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: CAS:84057-84-1

DrugCentral
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: Drug_Central:1540

Europe PMC
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: PMID:20825390

Europe PMC
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: PMID:21242744

Reaxys
type: Axiom
annotated source: lamotrigine
annotated property: database_cross_reference
annotated target: Reaxys:7589268

chemokine receptor 5 antagonist
type: Class
subclass of: antagonist
definition: An antogonist that blocks chemokine receptor 5 (CCR5).
has_related_synonym: CCR-5 antagonist
has_related_synonym: CCR-5 antagonists
has_related_synonym: CCR5 antagonist
has_related_synonym: CCR5 antagonists
has_related_synonym: chemokine receptor 5 antagonists
id: CHEBI:63673

neuroprotective agent
type: Class
subclass of: protective agent
definition: Any compound that can be used for the treatment of neurodegenerative disorders.
has_related_synonym: neuroprotectant
has_related_synonym: neuroprotectants
has_related_synonym: neuroprotective agents
id: CHEBI:63726

riddelliine
type: Class
subclass of: organic molecular entity
formula: C18H23NO6
description: A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
database_cross_reference: CAS:23246-96-0
has_exact_synonym: (15Z)-12,18-dihydroxy-13,19-didehydrosenecionan-11,16-dione

estrogen receptor agonist
type: Class
subclass of: agonist
definition: An agonist at the estrogen receptor.

protein kinase C agonist
type: Class
subclass of: protein kinase agonist
definition: An agonist that selectively binds to and activates a protein kinase C receptor
has_related_synonym: protein kinase C agonists
id: CHEBI:64018

leflunomide
type: Class
subclass of: organic molecular entity
definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
database_cross_reference: Beilstein:4323174
database_cross_reference: CAS:75706-12-6
database_cross_reference: DrugBank:DB01097
database_cross_reference: Drug_Central:1552
database_cross_reference: LINCS:LSM-3771
database_cross_reference: PMID:10515382
database_cross_reference: PMID:10702725
database_cross_reference: PMID:10890256
database_cross_reference: PMID:11043056
database_cross_reference: PMID:11053058
database_cross_reference: PMID:11067959
database_cross_reference: PMID:11271257
database_cross_reference: PMID:11333342
database_cross_reference: PMID:11340750
database_cross_reference: PMID:11391470
database_cross_reference: PMID:11475244
database_cross_reference: PMID:11522581
database_cross_reference: PMID:11707749
database_cross_reference: PMID:11718154
database_cross_reference: PMID:11876141
database_cross_reference: PMID:11884931
database_cross_reference: PMID:11994686
database_cross_reference: PMID:12017890
database_cross_reference: PMID:12074690
database_cross_reference: PMID:12833393
database_cross_reference: PMID:14622739
database_cross_reference: PMID:15030575
database_cross_reference: PMID:15127968
database_cross_reference: PMID:15127974
database_cross_reference: PMID:15188371
database_cross_reference: PMID:15214907
database_cross_reference: PMID:15385935
database_cross_reference: PMID:15489872
database_cross_reference: PMID:15537652
database_cross_reference: PMID:15652966
database_cross_reference: PMID:15665760
database_cross_reference: PMID:15789891
database_cross_reference: PMID:15899055
database_cross_reference: PMID:15934905
database_cross_reference: PMID:16106593
database_cross_reference: PMID:16142756
database_cross_reference: PMID:16202258
database_cross_reference: PMID:16284916
database_cross_reference: PMID:16638062
database_cross_reference: PMID:16638420
database_cross_reference: PMID:16645972
database_cross_reference: PMID:16688677
database_cross_reference: PMID:16769661
database_cross_reference: PMID:16778342
database_cross_reference: PMID:17366662
database_cross_reference: PMID:17604599
database_cross_reference: PMID:17646975
database_cross_reference: PMID:17854740
database_cross_reference: PMID:18034546
database_cross_reference: PMID:18173611
database_cross_reference: PMID:18413415
database_cross_reference: PMID:18496682
database_cross_reference: PMID:18663553
database_cross_reference: PMID:18688040
database_cross_reference: PMID:19169882
database_cross_reference: PMID:19190124
database_cross_reference: PMID:19344337
database_cross_reference: PMID:19581389
database_cross_reference: PMID:19715969
database_cross_reference: PMID:19751817
database_cross_reference: PMID:19770782
database_cross_reference: PMID:7496341
database_cross_reference: PMID:7676489
database_cross_reference: PMID:8610393
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database_cross_reference: PMID:9123314
database_cross_reference: PMID:9625011
database_cross_reference: PMID:9777697
database_cross_reference: Reaxys:4323174
has_exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
has_exact_synonym: Leflunomide
has_related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide

Beilstein
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ChemIDplus
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DrugCentral
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Reaxys
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protein kinase agonist
type: Class
subclass of: agonist
definition: An agonist that selectively binds to and activates a protein kinase receptor.
has_related_synonym: protein kinase agonists
id: CHEBI:64106

reaction intermediate
type: Class
subclass of: chemical role
definition: Any chemical substance produced during the conversion of a reactant to a product.
database_cross_reference: Wikipedia:Reaction_intermediate

posaconazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: trypanocidal drug
definition: An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug.
database_cross_reference: CAS:171228-49-2
database_cross_reference: DrugBank:DB01263
database_cross_reference: Drug_Central:3483
database_cross_reference: PMID:21762211
database_cross_reference: PMID:21967490
database_cross_reference: PMID:22058198
database_cross_reference: PMID:22176629
database_cross_reference: PMID:22215361
database_cross_reference: PMID:22215487
database_cross_reference: PMID:22286158
database_cross_reference: PMID:22290952
database_cross_reference: PMID:22303909
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database_cross_reference: PMID:22330929
database_cross_reference: PMID:22380765
database_cross_reference: PMID:22391464
database_cross_reference: PMID:22391534
database_cross_reference: PMID:22427614
database_cross_reference: Reaxys:8379448
has_exact_synonym: 2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-4-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
has_related_synonym: Noxafil
has_related_synonym: SCH56592
has_related_synonym: Sch 56592
has_related_synonym: Schering 56592
has_related_synonym: posaconazole
id: CHEBI:64355

ChemIDplus
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DrugCentral
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Europe PMC
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Reaxys
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glutamate transporter activator
type: Class
subclass of: neurotransmitter transporter modulator
definition: A neurotransmitter transporter modulator that activates glutamate transporters.
has_related_synonym: excitatory amino-acid transporter activator
has_related_synonym: excitatory amino-acid transporter activators
has_related_synonym: glutamate transporter activators
id: CHEBI:64370

neurotransmitter transporter modulator
type: Class
subclass of: neurotransmitter agent
subclass of: membrane transport modulator
definition: A membrane transport modulator that affects the transport of neurotransmitters.
has_related_synonym: neurotransmitter transporter modulators
id: CHEBI:64371

phosphatidylcholine
type: Class
subclass of: glycerophosphonocholine
definition: A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.

sphingomyelin
type: Class
subclass of: phosphosphingolipid
definition: Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine.
has_exact_synonym: Ceramide phosphocholine

poison
type: Class
subclass of: biological role
subclass of: aetiopathogenetic role
definition: Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
database_cross_reference: Wikipedia:Poison
has_related_synonym: poisonous agent
has_related_synonym: poisonous agents
has_related_synonym: poisonous substance
has_related_synonym: poisonous substances
has_related_synonym: poisons
has_related_synonym: toxic agent
has_related_synonym: toxic agents
has_related_synonym: toxic substance
has_related_synonym: toxic substances
id: CHEBI:64909

antimitotic
type: Class
subclass of: pharmacological role
definition: Any compound that inhibits cell division (mitosis).
has_related_synonym: antimitotics
has_related_synonym: mitosis inhibitor
has_related_synonym: mitosis inhibitors
has_related_synonym: mitotic inhibitor
has_related_synonym: mitotic inhibitors
id: CHEBI:64911

antimycobacterial drug
type: Class
subclass of: antibacterial drug
definition: A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy.
has_related_synonym: antimycobacterial agent
has_related_synonym: antimycobacterial agents
has_related_synonym: antimycobacterial drugs
has_related_synonym: antimycobacterials
has_related_synonym: antimycobacterium
id: CHEBI:64912

antiplasmodial drug
type: Class
subclass of: antiparasitic agent
subclass of: antiprotozoal drug
definition: An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria.
has_related_synonym: antiplasmodial agent
has_related_synonym: antiplasmodial agents
has_related_synonym: antiplasmodial drugs
has_related_synonym: antiplasmodium agent
has_related_synonym: antiplasmodium agents
has_related_synonym: antiplasmodium drug
has_related_synonym: antiplasmodium drugs
id: CHEBI:64915

serine protease inhibitor
type: Class
subclass of: protease inhibitor
definition: Any protease inhibitor that restricts the action of a serine protease.
has_related_synonym: serine protease inhibitors
has_related_synonym: serine proteinase inhibitor
has_related_synonym: serine proteinase inhibitors
id: CHEBI:64926

anti-HIV agent
type: Class
subclass of: antiviral agent
definition: An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
has_related_synonym: anti-AIDS agent
has_related_synonym: anti-AIDS agents
has_related_synonym: anti-HIV agents
id: CHEBI:64946

anti-HIV-1 agent
type: Class
subclass of: anti-HIV agent
definition: An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
has_related_synonym: anti-HIV-1 agents
has_related_synonym: anti-HTLV-III agent
has_related_synonym: anti-HTLV-III agents
has_related_synonym: anti-LAV agent
has_related_synonym: anti-LAV agents
id: CHEBI:64947

lipoprotein
type: Class
subclass of: biomacromolecule
definition: A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.

EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
type: Class
subclass of: lipoxygenase inhibitor
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
definition: A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
has_related_synonym: 5-LOX inhibitor
has_related_synonym: 5-LOX inhibitors
has_related_synonym: 5-lipoxygenase inhibitor
has_related_synonym: 5-lipoxygenase inhibitors
has_related_synonym: 5delta-lipoxygenase inhibitor
has_related_synonym: 5delta-lipoxygenase inhibitors
has_related_synonym: C-5-lipoxygenase inhibitor
has_related_synonym: C-5-lipoxygenase inhibitors
has_related_synonym: EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitors
has_related_synonym: EC 1.13.11.34 inhibitor
has_related_synonym: EC 1.13.11.34 inhibitors
has_related_synonym: LTA synthase inhibitor
has_related_synonym: LTA synthase inhibitors
has_related_synonym: arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitor
has_related_synonym: arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors
has_related_synonym: arachidonate 5-lipoxygenase inhibitor
has_related_synonym: arachidonate 5-lipoxygenase inhibitors
has_related_synonym: arachidonic 5-lipoxygenase inhibitor
has_related_synonym: arachidonic 5-lipoxygenase inhibitors
has_related_synonym: arachidonic acid 5-lipoxygenase inhibitor
has_related_synonym: arachidonic acid 5-lipoxygenase inhibitors
has_related_synonym: delta(5)-lipoxygenase inhibitor
has_related_synonym: delta(5)-lipoxygenase inhibitors
has_related_synonym: leukotriene A4 synthase inhibitor
has_related_synonym: leukotriene A4 synthase inhibitors
has_related_synonym: leukotriene-A4 synthase inhibitor
has_related_synonym: leukotriene-A4 synthase inhibitors
id: CHEBI:64964

EC 3.1.1.3 (triacylglycerol lipase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
definition: Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
has_related_synonym: EC 3.1.1.3 (triacylglycerol lipase) inhibitors
has_related_synonym: EC 3.1.1.3 inhibitor
has_related_synonym: EC 3.1.1.3 inhibitors
has_related_synonym: GEH inhibitor
has_related_synonym: GEH inhibitors
has_related_synonym: PPL inhibitor
has_related_synonym: PPL inhibitors
has_related_synonym: Tween hydrolase inhibitor
has_related_synonym: Tween hydrolase inhibitors
has_related_synonym: Tweenase inhibitor
has_related_synonym: Tweenase inhibitors
has_related_synonym: Tweenesterase inhibitor
has_related_synonym: Tweenesterase inhibitors
has_related_synonym: butyrinase inhibitor
has_related_synonym: butyrinase inhibitors
has_related_synonym: cacordase inhibitor
has_related_synonym: cacordase inhibitors
has_related_synonym: capalase L inhibitor
has_related_synonym: capalase L inhibitors
has_related_synonym: glycerol ester hydrolase inhibitor
has_related_synonym: glycerol ester hydrolase inhibitors
has_related_synonym: glycerol-ester hydrolase inhibitor
has_related_synonym: glycerol-ester hydrolase inhibitors
has_related_synonym: heparin releasable hepatic lipase inhibitor
has_related_synonym: heparin releasable hepatic lipase inhibitors
has_related_synonym: hepatic lipase inhibitor
has_related_synonym: hepatic lipase inhibitors
has_related_synonym: hepatic monoacylglycerol acyltransferase inhibitor
has_related_synonym: hepatic monoacylglycerol acyltransferase inhibitors
has_related_synonym: lipase inhibitor
has_related_synonym: lipase inhibitors
has_related_synonym: lipazin inhibitor
has_related_synonym: lipazin inhibitors
has_related_synonym: liver lipase inhibitor
has_related_synonym: liver lipase inhibitors
has_related_synonym: pancreatic lipase inhibitor
has_related_synonym: pancreatic lipase inhibitors
has_related_synonym: pancreatic triacylglycerol lipase inhibitor
has_related_synonym: pancreatic triacylglycerol lipase inhibitors
has_related_synonym: post-heparin plasma protamine-resistant lipase inhibitor
has_related_synonym: post-heparin plasma protamine-resistant lipase inhibitors
has_related_synonym: salt-resistant post-heparin lipase inhibitor
has_related_synonym: salt-resistant post-heparin lipase inhibitors
has_related_synonym: steapsin inhibitor
has_related_synonym: steapsin inhibitors
has_related_synonym: triacetinase inhibitor
has_related_synonym: triacetinase inhibitors
has_related_synonym: triacylglycerol ester hydrolase inhibitor
has_related_synonym: triacylglycerol ester hydrolase inhibitors
has_related_synonym: triacylglycerol lipase (EC 3.1.1.3) inhibitor
has_related_synonym: triacylglycerol lipase (EC 3.1.1.3) inhibitors
has_related_synonym: triacylglycerol lipase inhibitor
has_related_synonym: triacylglycerol lipase inhibitors
has_related_synonym: tributyrase inhibitor
has_related_synonym: tributyrase inhibitors
has_related_synonym: tributyrin esterase inhibitor
has_related_synonym: tributyrin esterase inhibitors
has_related_synonym: tributyrinase inhibitor
has_related_synonym: tributyrinase inhibitors
has_related_synonym: triglyceridase inhibitor
has_related_synonym: triglyceridase inhibitors
has_related_synonym: triglyceride hydrolase inhibitor
has_related_synonym: triglyceride hydrolase inhibitors
has_related_synonym: triglyceride lipase inhibitor
has_related_synonym: triglyceride lipase inhibitors
has_related_synonym: triolein hydrolase inhibitor
has_related_synonym: triolein hydrolase inhibitors
has_related_synonym: tween-hydrolysing esterase inhibitor
has_related_synonym: tween-hydrolyzing esterase inhibitors
id: CHEBI:65001

anti-asthmatic agent
type: Class
subclass of: drug
definition: Any compound that has anti-asthmatic effects.
has_related_synonym: anti-asthmatic agents
has_related_synonym: antiasthmatic agent
has_related_synonym: antiasthmatic agents
id: CHEBI:65023

ximelagatran
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anticoagulant
subclass of: Restriction
  on property: has role
  some values from: prodrug
subclass of: Restriction
  on property: has role
  some values from: serine protease inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 3.4.21.5 (thrombin) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.
database_cross_reference: CAS:192939-46-1
database_cross_reference: DrugBank:DB04898
database_cross_reference: Drug_Central:2852
database_cross_reference: PMID:12846595
database_cross_reference: PMID:15487959
database_cross_reference: PMID:16084146
database_cross_reference: PMID:16106594
database_cross_reference: PMID:16123912
database_cross_reference: PMID:16511607
database_cross_reference: PMID:16767816
database_cross_reference: PMID:17319469
database_cross_reference: PMID:17636192
database_cross_reference: PMID:19028773
database_cross_reference: PMID:20020269
database_cross_reference: PMID:28338626
database_cross_reference: Reaxys:14559655
has_exact_synonym: ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate
has_related_synonym: Exanta
has_related_synonym: Exarta
has_related_synonym: H 376-95
has_related_synonym: H 376/95
has_related_synonym: H 37695
has_related_synonym: ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin-1-yl]- 2-oxo-ethyl]amino]acetate
has_related_synonym: ximelagatran
has_related_synonym: ximelagatran (oxime form)
has_related_synonym: ximelagatranum
id: CHEBI:65172

ChemIDplus
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: CAS:192939-46-1

SUBMITTER
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: DrugBank:DB04898

DrugCentral
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: Drug_Central:2852

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:12846595

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:15487959

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:16084146

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:16106594

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:16123912

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:16511607

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:16767816

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:17319469

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:17636192

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:19028773

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:20020269

Europe PMC
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: PMID:28338626

Reaxys
type: Axiom
annotated source: ximelagatran
annotated property: database_cross_reference
annotated target: Reaxys:14559655

second generation antipsychotic
type: Class
subclass of: antipsychotic agent
subclass of: TXPO_0003658
definition: Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
database_cross_reference: Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
has_related_synonym: atypical antipsychotic
has_related_synonym: atypical antipsychotic agent
has_related_synonym: atypical antipsychotic agents
has_related_synonym: atypical antipsychotic drug
has_related_synonym: atypical antipsychotic drugs
has_related_synonym: atypical antipsychotics
has_related_synonym: second generation antipsychotic agent
has_related_synonym: second generation antipsychotic agents
has_related_synonym: second generation antipsychotic drug
has_related_synonym: second generation antipsychotic drugs
has_related_synonym: second generation antipsychotics
id: CHEBI:65191

vascular endothelial growth factor receptor antagonist
type: Class
subclass of: antagonist
definition: An antagonist at the vascular endothelial growth factor receptor.
has_related_synonym: VEGF receptor inhibitor
has_related_synonym: VEGF receptor inhibitors
has_related_synonym: VEGFR inhibitor
has_related_synonym: VEGFR inhibitors
has_related_synonym: vascular endothelial growth factor receptor antagonists
has_related_synonym: vascular endothelial growth factor receptor inhibitor
has_related_synonym: vascular endothelial growth factor receptor inhibitors
id: CHEBI:65207

EC 3.4.21.5 (thrombin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5).
has_related_synonym: E thrombin inhibitor
has_related_synonym: E thrombin inhibitors
has_related_synonym: EC 3.4.21.5 (thrombin) inhibitors
has_related_synonym: EC 3.4.21.5 inhibitor
has_related_synonym: EC 3.4.21.5 inhibitors
has_related_synonym: activated blood-coagulation factor II inhibitor
has_related_synonym: activated blood-coagulation factor II inhibitors
has_related_synonym: beta-thrombin inhibitor
has_related_synonym: beta-thrombin inhibitors
has_related_synonym: blood-coagulation factor IIa inhibitor
has_related_synonym: blood-coagulation factor IIa inhibitors
has_related_synonym: factor IIa inhibitor
has_related_synonym: factor IIa inhibitors
has_related_synonym: fibrinogenase inhibitor
has_related_synonym: fibrinogenase inhibitors
has_related_synonym: gamma-thrombin inhibitor
has_related_synonym: gamma-thrombin inhibitors
has_related_synonym: thrombase inhibitor
has_related_synonym: thrombase inhibitors
has_related_synonym: thrombin (EC 3.4.21.5) inhibitor
has_related_synonym: thrombin (EC 3.4.21.5) inhibitors
has_related_synonym: thrombin inhibitor
has_related_synonym: thrombin inhibitors
has_related_synonym: thrombin-C inhibitor
has_related_synonym: thrombin-C inhibitors
has_related_synonym: thrombofort inhibitor
has_related_synonym: thrombofort inhibitors
has_related_synonym: tropostasin inhibitor
has_related_synonym: tropostasin inhibitors
id: CHEBI:65232

GABA antagonist
type: Class
subclass of: antagonist
subclass of: GABA agent
definition: A compound that inhibits the action of gamma-aminobutyric acid.
has_related_synonym: GABA antagonists
has_related_synonym: gamma-aminobutyric acid receptor antagonist
has_related_synonym: gamma-aminobutyric acid receptor antagonists
id: CHEBI:65259

antidyskinesia agent
type: Class
subclass of: drug
definition: Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
has_related_synonym: antidyskinesia agents
has_related_synonym: antidyskinesia drug
has_related_synonym: antidyskinesia drugs
has_related_synonym: antidyskinetic agent
has_related_synonym: antidyskinetic agents
has_related_synonym: antidyskinetic drug
has_related_synonym: antidyskinetic drugs
id: CHEBI:66956

radiation protective agent
type: Class
subclass of: protective agent
id: CHEBI:66987

sympatholytic agent
type: Class
subclass of: adrenergic agent
definition: Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
has_related_synonym: sympatholytic
has_related_synonym: sympatholytic agents
has_related_synonym: sympatholytic drug
has_related_synonym: sympatholytic drugs
has_related_synonym: sympatholytics
id: CHEBI:66991

tocolytic agent
type: Class
subclass of: reproductive control drug
definition: Any compound used to suppress premature labour and immature birth by suppressing uterine contractions.
has_related_synonym: anti-contraction drug
has_related_synonym: anti-contraction drugs
has_related_synonym: anti-contraction medication
has_related_synonym: anti-contraction medications
has_related_synonym: labour repressant
has_related_synonym: labour repressants
has_related_synonym: tocolytic
has_related_synonym: tocolytic agents
has_related_synonym: tocolytic drug
has_related_synonym: tocolytic drugs
has_related_synonym: tocolytics
id: CHEBI:66993

insect sterilant
type: Class
subclass of: chemosterilant
subclass of: insecticide
definition: A chemosterilant intended to sterilize insects.
has_related_synonym: insect chemosterilant
has_related_synonym: insect chemosterilants
has_related_synonym: insect sterilants
id: CHEBI:67105

ryanodine receptor agonist
type: Class
subclass of: ryanodine receptor modulator
definition: A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
database_cross_reference: Wikipedia:Ryanodine_receptor
has_related_synonym: RyR activator
has_related_synonym: RyR agonists

mefenamic acid
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: antirheumatic drug
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
database_cross_reference: CAS:61-68-7
database_cross_reference: DrugBank:DB00784
database_cross_reference: Drug_Central:1663
database_cross_reference: LINCS:LSM-4085
database_cross_reference: PMID:14001132
database_cross_reference: PMID:17330662
database_cross_reference: PMID:22275128
database_cross_reference: PMID:22369458
database_cross_reference: PMID:23402341
database_cross_reference: PMID:23494912
database_cross_reference: PMID:23656341
database_cross_reference: PMID:2684858
database_cross_reference: PMID:28166217
database_cross_reference: PMID:3304401
database_cross_reference: PMID:4212650
database_cross_reference: PMID:425903
database_cross_reference: PMID:4916242
database_cross_reference: PMID:5286553
database_cross_reference: PMID:577447
database_cross_reference: PMID:6155061
database_cross_reference: Reaxys:2216243
has_exact_synonym: 2-[(2,3-dimethylphenyl)amino]benzoic acid
has_related_synonym: CI-473
has_related_synonym: CN 35355
has_related_synonym: CN-35355
has_related_synonym: INF 3355
has_related_synonym: INF-3355
has_related_synonym: Mefenaminsaeure
has_related_synonym: N-(2,3-xylyl)-2-aminobenzoic acid
has_related_synonym: N-2,3-xylylanthranilic acid
has_related_synonym: Ponstel
has_related_synonym: acide mefenamique
has_related_synonym: acido mefenamico
has_related_synonym: acidum mefenamicum
has_related_synonym: mefenamic acid
id: CHEBI:6717

ChemIDplus
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: CAS:61-68-7

NIST Chemistry WebBook
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: CAS:61-68-7

DrugCentral
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: Drug_Central:1663

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:14001132

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:17330662

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:22275128

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:22369458

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:23402341

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:23494912

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:23656341

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:2684858

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:28166217

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:3304401

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:4212650

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:425903

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:4916242

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:5286553

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:577447

Europe PMC
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: PMID:6155061

Reaxys
type: Axiom
annotated source: mefenamic acid
annotated property: database_cross_reference
annotated target: Reaxys:2216243

AP-1 antagonist
type: Class
subclass of: antagonist
definition: An antogonist that interferes with the action of activator protein 1 (AP-1).

EC 3.2.1.20 (alpha-glucosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-glucosidase (EC 3.2.1.20).
has_related_synonym: EC 3.2.1.20 (alpha-glucosidase) inhibitors
has_related_synonym: EC 3.2.1.20 inhibitor
has_related_synonym: EC 3.2.1.20 inhibitors
has_related_synonym: alpha-1,4-glucosidase inhibitor
has_related_synonym: alpha-1,4-glucosidase inhibitors
has_related_synonym: alpha-D-glucosidase inhibitor
has_related_synonym: alpha-D-glucosidase inhibitors
has_related_synonym: alpha-glucopyranosidase inhibitor
has_related_synonym: alpha-glucopyranosidase inhibitors
has_related_synonym: alpha-glucosidase (EC 3.2.1.20) inhibitor
has_related_synonym: alpha-glucosidase (EC 3.2.1.20) inhibitors
has_related_synonym: alpha-glucosidase inhibitor
has_related_synonym: alpha-glucosidase inhibitors
has_related_synonym: alpha-glucoside hydrolase inhibitor
has_related_synonym: alpha-glucoside hydrolase inhibitors
has_related_synonym: glucoinvertase inhibitor
has_related_synonym: glucoinvertase inhibitors
has_related_synonym: glucosidoinvertase inhibitor
has_related_synonym: glucosidoinvertase inhibitors
has_related_synonym: glucosidosucrase inhibitor
has_related_synonym: glucosidosucrase inhibitors
has_related_synonym: maltase inhibitor
has_related_synonym: maltase inhibitors
has_related_synonym: maltase-glucoamylase inhibitor
has_related_synonym: maltase-glucoamylase inhibitors
id: CHEBI:67239

meloxicam
type: Class
subclass of: organic molecular entity
definition: A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
database_cross_reference: DrugBank:DB00814
database_cross_reference: http://jglobal.jst.go.jp/en/redirect
has_exact_synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
has_exact_synonym: MLX

clofarabine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimetabolite
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
definition: A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
database_cross_reference: Beilstein:4882539
database_cross_reference: CAS:123318-82-1
database_cross_reference: DrugBank:DB00631
database_cross_reference: PMID:19929004
has_exact_synonym: 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
has_exact_synonym: clofarabine
has_related_synonym: (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
has_related_synonym: 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
has_related_synonym: 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
has_related_synonym: CAFdA
has_related_synonym: Cl-F-Ara-A
has_related_synonym: clofarabina
has_related_synonym: clofarabine
has_related_synonym: clofarabinum
id: CHEBI:681569

Beilstein
type: Axiom
annotated source: clofarabine
annotated property: database_cross_reference
annotated target: Beilstein:4882539

ChemIDplus
type: Axiom
annotated source: clofarabine
annotated property: database_cross_reference
annotated target: CAS:123318-82-1

ChEMBL
type: Axiom
annotated source: clofarabine
annotated property: database_cross_reference
annotated target: PMID:19929004

apoptosis inhibitor
type: Class
subclass of: TXPO_0000327
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: apoptotic process
definition: Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
has_related_synonym: Type I cell-death inhibitor

apoptosis inducer
type: Class
subclass of: biochemical role
subclass of: TXPO_0000327
subclass of: Restriction
  on property: capable of positively regulating
  some values from: apoptotic process
definition: Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
has_related_synonym: Type I cell-death inducer
has_related_synonym: Type I cell-death inducers
has_related_synonym: Type I programmed cell-death inducer
has_related_synonym: Type I programmed cell-death inducers
has_related_synonym: apoptosis inducers
id: CHEBI:68495

diethyl malate
type: Class
subclass of: organic molecular entity
definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
formula: C8H12O4
smiles: CCOC(=O)C=C/C(=O)OCC
database_cross_reference: CAS:141-05-9
database_cross_reference: PMID:1471155
database_cross_reference: PMID:1609410
database_cross_reference: PMID:3341033
has_exact_synonym: diethyl (2Z)-but-2-enedioate

glutathione depleting agent
type: Class
subclass of: TXPO_0000638
subclass of: TXPO_0002037
definition: A compound which causes a reduction in the levels of glutathione in cells.
has_exact_synonym: glutathione depletion agent role

EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor
type: Class
subclass of: EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor
definition: An EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor that interferes with the action of dihydroorotate oxidase (fumarate), EC 1.3.98.1 (formerly EC 1.3.3.1).
has_related_synonym: (S)-dihydroorotate:fumarate oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:fumarate oxidoreductase inhibitors
has_related_synonym: DHODH inhibitor
has_related_synonym: DHODH inhibitors
has_related_synonym: EC 1.3.3.1 inhibitor
has_related_synonym: EC 1.3.3.1 inhibitors
has_related_synonym: EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitor
has_related_synonym: EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitors
has_related_synonym: EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitors
has_related_synonym: EC 1.3.98.1 inhibitor
has_related_synonym: EC 1.3.98.1 inhibitors
has_related_synonym: dihydroorotate dehydrogenase inhibitor
has_related_synonym: dihydroorotate dehydrogenase inhibitors
has_related_synonym: dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitor
has_related_synonym: dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitors
has_related_synonym: dihydroorotate oxidase (fumarate) inhibitor
has_related_synonym: dihydroorotate oxidase (fumarate) inhibitors
id: CHEBI:68542

pyrimidine synthesis inhibitor
type: Class
subclass of: pathway inhibitor
definition: A pathway inhibitor that inhibits the synthesis of pyrimidine.
has_related_synonym: pyrimidine synthesis inhibitors
id: CHEBI:68543

P2Y12 receptor antagonist
type: Class
subclass of: purinergic receptor P2 antagonist
definition: An antagonist at the P2Y12 receptor
has_related_synonym: ADP receptor subtype P2Y12 antagonist
has_related_synonym: ADP receptor subtype P2Y12 antagonists
has_related_synonym: P2Y12 receptor antagonists
has_related_synonym: purinergic receptor subtype P2Y12 antagonist
has_related_synonym: purinergic receptor subtype P2Y12 antagonists
id: CHEBI:68563

mexiletine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anti-arrhythmia drug
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
database_cross_reference: CAS:31828-71-4
database_cross_reference: DrugBank:DB00379
database_cross_reference: Drug_Central:1794
database_cross_reference: LINCS:LSM-1700
database_cross_reference: PMID:10883344
database_cross_reference: PMID:11009230
database_cross_reference: Reaxys:2092205
has_exact_synonym: 1-(2,6-dimethylphenoxy)propan-2-amine
has_exact_synonym: Mexiletine
has_related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine
has_related_synonym: (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane
has_related_synonym: 1-(2',6'-dimethylphenoxy)-2-aminopropane
has_related_synonym: 1-(2,6-dimethylphenoxy)-2-propanamine
has_related_synonym: 1-methyl-2-(2,6-xylyloxy)ethanamine
has_related_synonym: mexiletina
has_related_synonym: mexiletine
has_related_synonym: mexiletinum
id: CHEBI:6916

ChemIDplus
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: CAS:31828-71-4

NIST Chemistry WebBook
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: CAS:31828-71-4

DrugCentral
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: Drug_Central:1794

Europe PMC
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: PMID:10883344

Europe PMC
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: PMID:11009230

Reaxys
type: Axiom
annotated source: mexiletine
annotated property: database_cross_reference
annotated target: Reaxys:2092205

topoisomerase inhibitor
type: Class
subclass of: EC 5.99.1.* (miscellaneous isomerase) inhibitor
definition: An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
has_related_synonym: topoisomerase inhibitors
id: CHEBI:70727

PPARalpha agonist
type: Class
subclass of: agonist
definition: A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
has_exact_synonym: PPAR-alpha agonist
has_exact_synonym: peroxisome proliferator-activated receptor-alpha agonist

pazopanib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: tyrosine kinase inhibitor
subclass of: Restriction
  on property: has role
  some values from: angiogenesis modulating agent
subclass of: Restriction
  on property: has role
  some values from: vascular endothelial growth factor receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
database_cross_reference: CAS:444731-52-6
database_cross_reference: Drug_Central:4118
database_cross_reference: LINCS:LSM-1114
database_cross_reference: PMID:21394443
database_cross_reference: PMID:21766486
database_cross_reference: PMID:21811833
database_cross_reference: PMID:22112314
database_cross_reference: PMID:22190407
database_cross_reference: PMID:22233389
database_cross_reference: PMID:22341567
database_cross_reference: PMID:22359392
database_cross_reference: PMID:22595799
database_cross_reference: PMID:22679111
database_cross_reference: PMID:22688250
database_cross_reference: PMID:22716487
database_cross_reference: PMID:22733110
database_cross_reference: PMID:22733795
database_cross_reference: PMID:22759480
database_cross_reference: PMID:22766517
database_cross_reference: PMID:22830347
database_cross_reference: PMID:22861374
database_cross_reference: PMID:22917595
database_cross_reference: PMID:22984765
database_cross_reference: PMID:23054212
database_cross_reference: PMID:23064954
database_cross_reference: PMID:23072642
database_cross_reference: PMID:23088634
database_cross_reference: PMID:23135778
database_cross_reference: Reaxys:11646488
has_exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
has_related_synonym: GW 78603
has_related_synonym: GW786034
has_related_synonym: pazopanib
has_related_synonym: pazopanibum
id: CHEBI:71219

ChemIDplus
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: CAS:444731-52-6

DrugCentral
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: Drug_Central:4118

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:21394443

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:21766486

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:21811833

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22112314

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22190407

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22233389

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22341567

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22359392

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22595799

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22679111

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22688250

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22716487

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22733110

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22733795

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22759480

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22766517

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22830347

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22861374

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22917595

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:22984765

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:23054212

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:23064954

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:23072642

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:23088634

Europe PMC
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: PMID:23135778

Reaxys
type: Axiom
annotated source: pazopanib
annotated property: database_cross_reference
annotated target: Reaxys:11646488

EC 2.* (transferase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)
has_related_synonym: EC 2 inhibitor
has_related_synonym: EC 2 inhibitors
has_related_synonym: EC 2.* (transferase) inhibitors
has_related_synonym: EC 2.* inhibitor
has_related_synonym: EC 2.* inhibitors
has_related_synonym: transferase inhibitor
has_related_synonym: transferase inhibitors
id: CHEBI:71300

nitrofurantoin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.
database_cross_reference: CAS:67-20-9
database_cross_reference: DrugBank:DB00698
database_cross_reference: Drug_Central:1949
database_cross_reference: PMID:21567157
database_cross_reference: PMID:22240115
database_cross_reference: PMID:22252772
database_cross_reference: PMID:22252808
database_cross_reference: PMID:22285235
database_cross_reference: PMID:22332195
database_cross_reference: PMID:22508296
database_cross_reference: PMID:22535452
database_cross_reference: PMID:22552451
database_cross_reference: PMID:22722224
database_cross_reference: PMID:22779302
database_cross_reference: PMID:22787489
database_cross_reference: PMID:22836745
database_cross_reference: PMID:22857139
database_cross_reference: PMID:22869929
database_cross_reference: PMID:22876623
database_cross_reference: PMID:22923965
database_cross_reference: PMID:22929632
database_cross_reference: PMID:22977056
database_cross_reference: PMID:23016316
database_cross_reference: PMID:23109011
database_cross_reference: PMID:23113731
database_cross_reference: PMID:23114172
database_cross_reference: Reaxys:8132135
has_exact_synonym: 1-{[(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione
has_related_synonym: 1-((5-Nitrofurfurylidene)amino)hydantoin
has_related_synonym: 1-(5-Nitro-2-furfurylidenamino)hydantoin
has_related_synonym: 1-(5-Nitro-2-furfurylideneamino)hydantoin
has_related_synonym: 1-[(5-Nitrofurfurylidene)amino]hydantoin
has_related_synonym: 5-Nitrofurantoin
has_related_synonym: N-(5-Nitrofurfurylidene)-1-aminohydantoin
has_related_synonym: nitrofurantoin
has_related_synonym: nitrofurantoina
has_related_synonym: nitrofurantoine
has_related_synonym: nitrofurantoinum
id: CHEBI:71415

ChemIDplus
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: CAS:67-20-9

NIST Chemistry WebBook
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: CAS:67-20-9

DrugCentral
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: Drug_Central:1949

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:21567157

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22240115

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22252772

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22252808

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22285235

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22332195

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22508296

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22535452

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22552451

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22722224

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22779302

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22787489

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22836745

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22857139

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22869929

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22876623

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22923965

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22929632

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:22977056

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:23016316

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:23109011

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:23113731

Europe PMC
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: PMID:23114172

Reaxys
type: Axiom
annotated source: nitrofurantoin
annotated property: database_cross_reference
annotated target: Reaxys:8132135

EC 2.3.1.85 (fatty acid synthase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis.
has_related_synonym: (FAS) inhibitors
has_related_synonym: EC 2.3.1.85 (fatty acid synthase) inhibitors
has_related_synonym: EC 2.3.1.85 inhibitor
has_related_synonym: EC 2.3.1.85 inhibitors
has_related_synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitor
has_related_synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitors
has_related_synonym: fatty acid synthase (EC 2.3.1.85) inhibitor
has_related_synonym: fatty acid synthase (EC 2.3.1.85) inhibitors
has_related_synonym: fatty acid synthase inhibitor
has_related_synonym: fatty acid synthase inhibitors
id: CHEBI:71476

PPARgamma agonist
type: Class
subclass of: agonist
definition: A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
has_exact_synonym: PPAR-gamma agonist
has_exact_synonym: peroxisome proliferator-activated receptor-gamma agonist

organic molecule
type: Class
subclass of: molecule
definition: Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
has_exact_synonym: organic compound

aryl hydrocarbon receptor agonist
type: Class
subclass of: agonist
definition: An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
has_related_synonym: AHR agonist

lumiracoxib
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 2 inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
database_cross_reference: CAS:220991-20-8
database_cross_reference: DrugBank:DB01283
database_cross_reference: Drug_Central:1618
database_cross_reference: PMID:14965322
database_cross_reference: PMID:15311562
database_cross_reference: PMID:15456339
database_cross_reference: PMID:17380211
database_cross_reference: PMID:19800190
database_cross_reference: PMID:21688392
database_cross_reference: PMID:22069133
database_cross_reference: PMID:22142375
database_cross_reference: PMID:22621454
database_cross_reference: PMID:22732767
database_cross_reference: Reaxys:9784107
has_exact_synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
has_related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid
has_related_synonym: COX 189
has_related_synonym: COX-189
has_related_synonym: COX189
has_related_synonym: Prexige
has_related_synonym: lumiracoxib
has_related_synonym: lumiracoxibum
id: CHEBI:73044

ChemIDplus
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: CAS:220991-20-8

DrugCentral
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: Drug_Central:1618

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:14965322

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:15311562

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:15456339

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:17380211

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:19800190

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:21688392

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:22069133

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:22142375

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:22621454

Europe PMC
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: PMID:22732767

Reaxys
type: Axiom
annotated source: lumiracoxib
annotated property: database_cross_reference
annotated target: Reaxys:9784107

EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*).
has_related_synonym: EC 3.6 inhibitor
has_related_synonym: EC 3.6 inhibitors
has_related_synonym: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors
has_related_synonym: EC 3.6.* inhibitor
has_related_synonym: EC 3.6.* inhibitors
has_related_synonym: EC 3.6.*.* inhibitor
has_related_synonym: EC 3.6.*.* inhibitors
has_related_synonym: acid anhydride hydrolase inhibitor
has_related_synonym: acid anhydride hydrolase inhibitors
has_related_synonym: inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)
has_related_synonym: inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)
id: CHEBI:73216

NF-kappaB inhibitor
type: Class
subclass of: inhibitor
subclass of: TXPO_0003711
definition: An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.
has_related_synonym: NF-kappaB inhibitors
has_related_synonym: nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor
has_related_synonym: nuclear factor kappa-light-chain-enhancer of activated B cells inhibitors
id: CHEBI:73240

ketone body
type: Class
subclass of: icosanoid
definition: A carbonyl compound produced as a water-soluble byproduct when fatty acids are broken down for energy in the liver. There are three endogenous ketone bodies: acetone, acetoacetic acid, and (R)-3-hydroxybutyric acid; others may be produced as a result of the metabolism of synthetic triglycerides.

antifolate
type: Class
subclass of: antimetabolite
definition: An antimetabolite that impairs the action of folic acids
has_related_synonym: antifolates
has_related_synonym: folic acid antagonist
has_related_synonym: folic acid antagonists
id: CHEBI:73913

EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
type: Class
subclass of: EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor
definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
has_related_synonym: 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitor
has_related_synonym: 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitors
has_related_synonym: ADP reductase inhibitor
has_related_synonym: ADP reductase inhibitors
has_related_synonym: CDP reductase inhibitor
has_related_synonym: CDP reductase inhibitors
has_related_synonym: EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitors
has_related_synonym: EC 1.17.4.1 inhibitor
has_related_synonym: EC 1.17.4.1 inhibitors
has_related_synonym: RR inhibitor
has_related_synonym: RR inhibitors
has_related_synonym: UDP reductase inhibitor
has_related_synonym: UDP reductase inhibitors
has_related_synonym: nucleoside diphosphate reductase inhibitor
has_related_synonym: nucleoside diphosphate reductase inhibitors
has_related_synonym: ribonucleoside diphosphate reductase inhibitor
has_related_synonym: ribonucleoside diphosphate reductase inhibitors
has_related_synonym: ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor
has_related_synonym: ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitors
has_related_synonym: ribonucleoside-diphosphate reductase inhibitor
has_related_synonym: ribonucleoside-diphosphate reductase inhibitors
has_related_synonym: ribonucleotide diphosphate reductase inhibitor
has_related_synonym: ribonucleotide diphosphate reductase inhibitors
has_related_synonym: ribonucleotide reductase inhibitor
has_related_synonym: ribonucleotide reductase inhibitors
id: CHEBI:74213

epidermal growth factor receptor antagonist
type: Class
subclass of: protein kinase inhibitor
subclass of: antagonist
definition: An antagonist at the epidermal growth factor receptor.
has_related_synonym: EGFR antagonoist
has_related_synonym: EGFR antagonoists
has_related_synonym: EGFR inhibitor
has_related_synonym: EGFR inhibitors
has_related_synonym: epidermal growth factor receptor antagonists
has_related_synonym: epidermal growth factor receptor inhibitor
has_related_synonym: epidermal growth factor receptor inhibitors
id: CHEBI:74440

anti-obesity agent
type: Class
subclass of: pharmacological role
definition: Any substance which is used to reduce or control weight.
has_related_synonym: anti-obesity agents
has_related_synonym: anti-obestic agent
has_related_synonym: anti-obestic agents
id: CHEBI:74518

nandrolone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: human metabolite
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.
database_cross_reference: Beilstein:2055849
database_cross_reference: Beilstein:4690380
database_cross_reference: CAS:434-22-0
database_cross_reference: DrugBank:DB00984
database_cross_reference: Drug_Central:1879
database_cross_reference: Gmelin:1228044
database_cross_reference: PMID:11888015
database_cross_reference: PMID:19055689
database_cross_reference: PMID:20020363
database_cross_reference: PMID:24405322
database_cross_reference: Reaxys:2055849
has_exact_synonym: 17beta-hydroxyestr-4-en-3-one
has_exact_synonym: Nandrolone
has_related_synonym: (17beta)-17-hydroxyestr-4-en-3-one
has_related_synonym: 17beta-hydroxy-19-nor-4-androsten-3-one
has_related_synonym: 17beta-hydroxy-4-estren-3-one
has_related_synonym: 17beta-hydroxyestr-4-en-3-one
has_related_synonym: 19-Norandrostenolone
has_related_synonym: 19-Nortestosterone
has_related_synonym: 4-estren-17beta-ol-3-one
id: CHEBI:7466

Beilstein
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: Beilstein:2055849

Beilstein
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: Beilstein:4690380

ChemIDplus
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: CAS:434-22-0

DrugCentral
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: Drug_Central:1879

Gmelin
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: Gmelin:1228044

Europe PMC
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: PMID:11888015

Europe PMC
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: PMID:19055689

Europe PMC
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: PMID:20020363

Europe PMC
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: PMID:24405322

Reaxys
type: Axiom
annotated source: nandrolone
annotated property: database_cross_reference
annotated target: Reaxys:2055849

nefazodone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: analgesic
subclass of: Restriction
  on property: has role
  some values from: alpha-adrenergic antagonist
subclass of: Restriction
  on property: has role
  some values from: serotonergic antagonist
subclass of: Restriction
  on property: has role
  some values from: serotonin uptake inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:4728403
database_cross_reference: CAS:83366-66-9
database_cross_reference: DrugBank:DB01149
database_cross_reference: Drug_Central:1890
database_cross_reference: LINCS:LSM-4031
has_exact_synonym: 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
has_exact_synonym: Nefazodone
has_exact_synonym: nefazodone
has_related_synonym: 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one
has_related_synonym: nefazodona
has_related_synonym: nefazodone
has_related_synonym: nefazodonum
id: CHEBI:7494

Beilstein
type: Axiom
annotated source: nefazodone
annotated property: database_cross_reference
annotated target: Beilstein:4728403

ChemIDplus
type: Axiom
annotated source: nefazodone
annotated property: database_cross_reference
annotated target: CAS:83366-66-9

DrugCentral
type: Axiom
annotated source: nefazodone
annotated property: database_cross_reference
annotated target: Drug_Central:1890

nelfinavir
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: HIV protease inhibitor
definition: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.
formula: C32H45N3O4S

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
type: Class
subclass of: organic molecular entity
definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
formula: C26H41N3O5
formula: PubChem:462382
database_cross_reference: Wikipedia:MG132
has_exact_synonym: MG-132

EC 5.* (isomerase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*).
has_related_synonym: EC 5.* (isomerase) inhibitors
has_related_synonym: EC 5.* inhibitor
has_related_synonym: EC 5.* inhibitors
has_related_synonym: EC 5.*.*.* inhibitor
has_related_synonym: EC 5.*.*.* inhibitors
has_related_synonym: isomerase (EC 5.*) inhibitor
has_related_synonym: isomerase (EC 5.*) inhibitors
has_related_synonym: isomerase inhibitor
has_related_synonym: isomerase inhibitors
id: CHEBI:75596

nilutamide
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: androgen antagonist
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. (by Wikipedia)
formula: C12H10F3N3O4
database_cross_reference: Beilstein:841906
database_cross_reference: CAS:63612-50-0
database_cross_reference: DrugBank:DB00665
database_cross_reference: Drug_Central:1933
database_cross_reference: LINCS:LSM-2513
database_cross_reference: Wikipedia:Nilutamide
has_exact_synonym: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
has_exact_synonym: Nilutamide
has_related_synonym: 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin
has_related_synonym: Nilandron
has_related_synonym: nilutamida
has_related_synonym: nilutamide
has_related_synonym: nilutamidum
id: CHEBI:7573

Beilstein
type: Axiom
annotated source: nilutamide
annotated property: database_cross_reference
annotated target: Beilstein:841906

ChemIDplus
type: Axiom
annotated source: nilutamide
annotated property: database_cross_reference
annotated target: CAS:63612-50-0

DrugCentral
type: Axiom
annotated source: nilutamide
annotated property: database_cross_reference
annotated target: Drug_Central:1933

eukaryotic metabolite
type: Class
subclass of: metabolite
definition: Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
has_related_synonym: eukaryotic metabolites
id: CHEBI:75763

animal metabolite
type: Class
subclass of: eukaryotic metabolite
definition: Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
has_related_synonym: animal metabolites
id: CHEBI:75767

mammalian metabolite
type: Class
subclass of: animal metabolite
definition: Any animal metabolite produced during a metabolic reaction in mammals.
has_related_synonym: mammalian metabolites
id: CHEBI:75768

mouse metabolite
type: Class
subclass of: mammalian metabolite
definition: Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
has_related_synonym: Mus musculus metabolite
has_related_synonym: Mus musculus metabolites
has_related_synonym: mouse metabolites
id: CHEBI:75771

prokaryotic metabolite
type: Class
subclass of: metabolite
definition: Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
has_related_synonym: prokaryotic metabolites
id: CHEBI:75787

benoxaprofen
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: antipsoriatic
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has role
  some values from: nephrotoxin
subclass of: Restriction
  on property: has role
  some values from: protein kinase C agonist
subclass of: Restriction
  on property: has role
  some values from: EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
database_cross_reference: CAS:51234-28-7
database_cross_reference: DrugBank:DB04812
database_cross_reference: Drug_Central:311
database_cross_reference: PMID:19439485
database_cross_reference: PMID:19773537
database_cross_reference: PMID:21128314
database_cross_reference: PMID:22514582
database_cross_reference: PMID:23250699
database_cross_reference: PMID:2413686
database_cross_reference: PMID:2833969
database_cross_reference: PMID:2947294
database_cross_reference: PMID:3981515
database_cross_reference: PMID:6407402
database_cross_reference: PMID:6526401
database_cross_reference: PMID:6645654
database_cross_reference: PMID:6813936
database_cross_reference: PMID:6993669
database_cross_reference: PMID:6993670
database_cross_reference: PMID:6993671
database_cross_reference: PMID:6993672
database_cross_reference: PMID:7044799
database_cross_reference: PMID:7044801
database_cross_reference: PMID:7084283
database_cross_reference: PMID:7084287
database_cross_reference: PMID:7221526
database_cross_reference: Reaxys:1085080
has_exact_synonym: 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
has_related_synonym: (+-)-benoxaprofen
has_related_synonym: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid
has_related_synonym: 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
has_related_synonym: 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
has_related_synonym: 2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
has_related_synonym: DL-benoxaprofen
has_related_synonym: Lilly 90459
has_related_synonym: benoxaprofen
has_related_synonym: benoxaprofene
has_related_synonym: benoxaprofeno
has_related_synonym: benoxaprofenum
id: CHEBI:76114

ChemIDplus
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: CAS:51234-28-7

NIST Chemistry WebBook
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: CAS:51234-28-7

DrugCentral
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: Drug_Central:311

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:19439485

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:19773537

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:21128314

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:22514582

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:23250699

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:2413686

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:2833969

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:2947294

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:3981515

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6407402

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6526401

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6645654

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6813936

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6993669

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6993670

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6993671

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:6993672

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:7044799

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:7044801

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:7084283

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:7084287

Europe PMC
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: PMID:7221526

Reaxys
type: Axiom
annotated source: benoxaprofen
annotated property: database_cross_reference
annotated target: Reaxys:1085080

droxicam
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: prodrug
subclass of: Restriction
  on property: has role
  some values from: platelet aggregation inhibitor
subclass of: Restriction
  on property: has role
  some values from: cyclooxygenase 1 inhibitor
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
database_cross_reference: CAS:90101-16-9
database_cross_reference: Drug_Central:970
database_cross_reference: PMID:12093490
database_cross_reference: PMID:1365484
database_cross_reference: PMID:1365486
database_cross_reference: PMID:1365487
database_cross_reference: PMID:1365489
database_cross_reference: PMID:1365490
database_cross_reference: PMID:1365491
database_cross_reference: PMID:1487550
database_cross_reference: PMID:1507922
database_cross_reference: PMID:1507923
database_cross_reference: PMID:1507924
database_cross_reference: PMID:1545609
database_cross_reference: PMID:23656309
database_cross_reference: PMID:2778095
database_cross_reference: PMID:3110512
database_cross_reference: PMID:3221746
database_cross_reference: PMID:3278945
database_cross_reference: PMID:3489870
database_cross_reference: PMID:3762266
database_cross_reference: PMID:8489815
database_cross_reference: PMID:8492964
database_cross_reference: PMID:8616003
database_cross_reference: PMID:8656732
database_cross_reference: PMID:8983932
database_cross_reference: Reaxys:6006252
has_exact_synonym: 5-methyl-3-(pyridin-2-yl)-2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
has_related_synonym: droxicam
has_related_synonym: droxicamum
id: CHEBI:76133

ChemIDplus
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: CAS:90101-16-9

DrugCentral
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: Drug_Central:970

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:12093490

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365484

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365486

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365487

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365489

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365490

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1365491

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1487550

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1507922

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1507923

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1507924

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:1545609

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:23656309

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:2778095

Europe PMC
type: Axiom
annotated source: droxicam
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annotated target: PMID:3110512

Europe PMC
type: Axiom
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annotated target: PMID:3221746

Europe PMC
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annotated target: PMID:3278945

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:3489870

Europe PMC
type: Axiom
annotated source: droxicam
annotated property: database_cross_reference
annotated target: PMID:3762266

Europe PMC
type: Axiom
annotated source: droxicam
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annotated target: PMID:8489815

Europe PMC
type: Axiom
annotated source: droxicam
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Europe PMC
type: Axiom
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Europe PMC
type: Axiom
annotated source: droxicam
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annotated target: PMID:8656732

Europe PMC
type: Axiom
annotated source: droxicam
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annotated target: PMID:8983932

Reaxys
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annotated source: droxicam
annotated property: database_cross_reference
annotated target: Reaxys:6006252

ibufenac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.
database_cross_reference: CAS:1553-60-2
database_cross_reference: Drug_Central:3293
database_cross_reference: PMID:1479559
database_cross_reference: PMID:16456879
database_cross_reference: PMID:21128314
database_cross_reference: PMID:2585272
database_cross_reference: PMID:3215965
database_cross_reference: PMID:5329891
database_cross_reference: PMID:5657238
database_cross_reference: PMID:5748163
database_cross_reference: PMID:5752436
database_cross_reference: PMID:5807207
database_cross_reference: PMID:687781
database_cross_reference: PMID:7587932
database_cross_reference: PMID:9061203
database_cross_reference: Reaxys:2046683
has_exact_synonym: (4-isobutylphenyl)acetic acid
has_exact_synonym: [4-(2-methylpropyl)phenyl]acetic acid
has_related_synonym: (p-Isobutylphenyl)acetic acid
has_related_synonym: 4-(2-Methylpropyl)benzeneacetic acid
has_related_synonym: 4-Isobutylphenylacetic acid
has_related_synonym: Dytransin
has_related_synonym: Ibunac
has_related_synonym: ibufenac
has_related_synonym: ibufenaco
has_related_synonym: ibufenacum
id: CHEBI:76158

ChemIDplus
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: CAS:1553-60-2

DrugCentral
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: Drug_Central:3293

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:1479559

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:16456879

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:21128314

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:2585272

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:3215965

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:5329891

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:5657238

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:5748163

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:5752436

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:5807207

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:687781

Europe PMC
type: Axiom
annotated source: ibufenac
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annotated target: PMID:7587932

Europe PMC
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: PMID:9061203

Reaxys
type: Axiom
annotated source: ibufenac
annotated property: database_cross_reference
annotated target: Reaxys:2046683

xenobiotic metabolite
type: Class
subclass of: metabolite
definition: Any metabolite produced by metabolism of a xenobiotic compound.
has_related_synonym: xenobiotic metabolites
id: CHEBI:76206

nortriptyline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antidepressant
subclass of: Restriction
  on property: has role
  some values from: analgesic
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: adrenergic uptake inhibitor
subclass of: Restriction
  on property: has role
  some values from: drug metabolite
subclass of: Restriction
  on property: has role
  some values from: apoptosis inducer
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
database_cross_reference: Beilstein:2216786
database_cross_reference: CAS:72-69-5
database_cross_reference: DrugBank:DB00540
database_cross_reference: Drug_Central:1971
database_cross_reference: LINCS:LSM-4039
database_cross_reference: PMID:10379421
database_cross_reference: PMID:14561440
database_cross_reference: PMID:17071817
database_cross_reference: PMID:23280809
database_cross_reference: PMID:24037379
database_cross_reference: PMID:24368464
database_cross_reference: PMID:25224004
database_cross_reference: PMID:25480462
database_cross_reference: PMID:25569864
database_cross_reference: PMID:25592638
database_cross_reference: PMID:25683584
database_cross_reference: PMID:25707462
database_cross_reference: PMID:25749306
database_cross_reference: PMID:26086857
database_cross_reference: PMID:26453560
database_cross_reference: Reaxys:2216786
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
has_exact_synonym: Nortriptyline
has_related_synonym: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
has_related_synonym: Ateben
has_related_synonym: Avantyl
has_related_synonym: Aventyl
has_related_synonym: Noritren
has_related_synonym: Psychostyl
has_related_synonym: Sensaval
has_related_synonym: demethylamitriptyline
has_related_synonym: desmethylamitriptyline
has_related_synonym: nortriptylina
has_related_synonym: nortriptyline
has_related_synonym: nortriptylinum
id: CHEBI:7640

ChemIDplus
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: Beilstein:2216786

ChemIDplus
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: CAS:72-69-5

NIST Chemistry WebBook
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: CAS:72-69-5

DrugCentral
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: Drug_Central:1971

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:10379421

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:14561440

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:17071817

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:23280809

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:24037379

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:24368464

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25224004

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25480462

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25569864

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25592638

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25683584

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25707462

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:25749306

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:26086857

Europe PMC
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: PMID:26453560

Reaxys
type: Axiom
annotated source: nortriptyline
annotated property: database_cross_reference
annotated target: Reaxys:2216786

Chlorendic Acid
type: Class
subclass of: organic molecular entity
definition: A bridged organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with maleic anhydride followed by hydrolysis of the resulting anhydride. A chemical intermediate used in the preparation of fire-retardant polyester resins and plasticisers.
formula: C9H4Cl6O4
database_cross_reference: CAS:115-28-6
has_exact_synonym: 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid

EC 2.1.* (C1-transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
definition: A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*).
has_related_synonym: C1-transferase (EC 2.1.*) inhibitor
has_related_synonym: C1-transferase (EC 2.1.*) inhibitors
has_related_synonym: C1-transferase inhibitor
has_related_synonym: C1-transferase inhibitors
has_related_synonym: EC 2.1.* (C1-transferase) inhibitors
has_related_synonym: EC 2.1.* inhibitor
has_related_synonym: EC 2.1.* inhibitors
has_related_synonym: one-carbon-containing group transferase inhibitor
has_related_synonym: one-carbon-containing group transferase inhibitors
id: CHEBI:76655

EC 2.3.* (acyltransferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
definition: A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*).
has_related_synonym: EC 2.3.* (acyltransferase) inhibitors
has_related_synonym: EC 2.3.* inhibitor
has_related_synonym: EC 2.3.* inhibitors
has_related_synonym: acyltransferase inhibitor
has_related_synonym: acyltransferase inhibitors
id: CHEBI:76661

EC 2.4.* (glycosyltransferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
definition: A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*).
has_related_synonym: EC 2.4.* (glycosyltransferase) inhibitors
has_related_synonym: EC 2.4.* inhibitor
has_related_synonym: EC 2.4.* inhibitors
has_related_synonym: glycosyltransferase (EC 2.4.*) inhibitor
has_related_synonym: glycosyltransferase (EC 2.4.*) inhibitors
has_related_synonym: glycosyltransferase inhibitor
has_related_synonym: glycosyltransferase inhibitors
id: CHEBI:76662

EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
type: Class
subclass of: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
definition: A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*).
has_related_synonym: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors
has_related_synonym: EC 2.5.1.* inhibitor
has_related_synonym: EC 2.5.1.* inhibitors
has_related_synonym: alkyl/aryl (non-methyl) transferase inhibitor
has_related_synonym: alkyl/aryl (non-methyl) transferase inhibitors
has_related_synonym: non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor
has_related_synonym: non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors
has_related_synonym: non-methyl alkyl/aryl transferase inhibitor
has_related_synonym: non-methyl alkyl/aryl transferase inhibitors
has_related_synonym: non-methyl-alkyl or aryl transferase inhibitor
has_related_synonym: non-methyl-alkyl or aryl transferase inhibitors
id: CHEBI:76663

EC 2.7.* (P-containing group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
definition: A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*).
has_related_synonym: EC 2.7.* (P-containing group transferase) inhibitors
has_related_synonym: EC 2.7.* (phosphorus-containing group transferase) inhibitor
has_related_synonym: EC 2.7.* (phosphorus-containing group transferase) inhibitors
has_related_synonym: EC 2.7.* inhibitor
has_related_synonym: EC 2.7.* inhibitors
has_related_synonym: phosphorus-containing group transferase (EC 2.7.*) inhibitor
has_related_synonym: phosphorus-containing group transferase (EC 2.7.*) inhibitors
has_related_synonym: phosphorus-containing group transferase inhibitor
has_related_synonym: phosphorus-containing group transferase inhibitors
id: CHEBI:76668

EC 5.99.* (other isomerases) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
definition: An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*).
has_related_synonym: EC 5.99.* (miscellaneous isomerases) inhibitor
has_related_synonym: EC 5.99.* (miscellaneous isomerases) inhibitors
has_related_synonym: EC 5.99.* (other isomerase) inhibitor
has_related_synonym: EC 5.99.* (other isomerase) inhibitors
has_related_synonym: EC 5.99.* (other isomerases) inhibitors
has_related_synonym: EC 5.99.* inhibitor
has_related_synonym: EC 5.99.* inhibitors
id: CHEBI:76697

EC 4.* (lyase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation.
has_related_synonym: EC 4.* (lyase) inhibitors
has_related_synonym: EC 4.* inhibitor
has_related_synonym: EC 4.* inhibitors
has_related_synonym: EC 4.*.*.* inhibitor
has_related_synonym: EC 4.*.*.* inhibitors
has_related_synonym: lyase (EC 4.*) inhibitor
has_related_synonym: lyase (EC 4.*) inhibitorS
has_related_synonym: lyase inhibitor
has_related_synonym: lyase inhibitors
id: CHEBI:76710

EC 4.2.* (C-O lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
definition: A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*).
has_related_synonym: C-O lyase (EC 4.2.*) inhibitor
has_related_synonym: C-O lyase (EC 4.2.*) inhibitors
has_related_synonym: C-O lyase inhibitor
has_related_synonym: C-O lyase inhibitors
has_related_synonym: EC 4.2.* (C-O lyase) inhibitors
has_related_synonym: EC 4.2.* inhibitor
has_related_synonym: EC 4.2.* inhibitors
id: CHEBI:76712

EC 1.* (oxidoreductase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).
has_related_synonym: EC 1.* (oxidoreductase) inhibitors
has_related_synonym: EC 1.* inhibitor
has_related_synonym: EC 1.* inhibitors
has_related_synonym: oxidoreductase (EC 1.*) inhibitor
has_related_synonym: oxidoreductase (EC 1.*) inhibitors
has_related_synonym: oxidoreductase inhibitor
has_related_synonym: oxidoreductase inhibitors
id: CHEBI:76725

EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
has_related_synonym: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors
has_related_synonym: EC 1.1.* inhibitor
has_related_synonym: EC 1.1.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-OH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-OH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-OH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-OH group of donors
has_related_synonym: oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group inhibitors
id: CHEBI:76726

EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*).
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors
has_related_synonym: EC 1.2.* inhibitor
has_related_synonym: EC 1.2.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde or oxo group of donor
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde or oxo group of donors
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde/oxo group of donor
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde/oxo group of donors
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde or oxo group of donor
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde or oxo group of donors
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde/oxo group of donor
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde/oxo group of donors
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group inhibitors
id: CHEBI:76727

EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*).
has_related_synonym: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors
has_related_synonym: EC 1.3.* inhibitor
has_related_synonym: EC 1.3.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH group of donors
has_related_synonym: oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors
has_related_synonym: oxidoreductase acting on donor CH-CH group inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group inhibitors
id: CHEBI:76729

EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*).
has_related_synonym: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors
has_related_synonym: EC 1.5.* inhibitor
has_related_synonym: EC 1.5.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH group of donors
has_related_synonym: oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors
id: CHEBI:76731

EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*).
has_related_synonym: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on NADH or NADPH
has_related_synonym: inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
has_related_synonym: inhibitors of oxidoreductase acting on NADH or NADPH
has_related_synonym: inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
has_related_synonym: oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors
has_related_synonym: oxidoreductase acting on NADH or NADPH inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH inhibitors
id: CHEBI:76733

EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors).
has_related_synonym: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors
has_related_synonym: EC 1.8.* inhibitor
has_related_synonym: EC 1.8.* inhibitors
has_related_synonym: oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor
has_related_synonym: oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors
id: CHEBI:76735

EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on diphenols and related substances as donors (EC 1.10.*.*).
has_related_synonym: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitors
has_related_synonym: EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitor
has_related_synonym: EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitors
has_related_synonym: EC 1.10.* inhibitor
has_related_synonym: EC 1.10.* inhibitors
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donor
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donors
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donor
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donors
id: CHEBI:76737

EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*.
has_related_synonym: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors
has_related_synonym: EC 1.13.* inhibitor
has_related_synonym: EC 1.13.* inhibitors
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors
id: CHEBI:76740

EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*).
has_related_synonym: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
has_related_synonym: EC 1.14.* inhibitor
has_related_synonym: EC 1.14.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors
id: CHEBI:76741

EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*).
has_related_synonym: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors
has_related_synonym: EC 1.17.* inhibitor
has_related_synonym: EC 1.17.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 inhibitors
id: CHEBI:76744

EC 3.* (hydrolase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
has_exact_synonym: EC 3.* (hydrolase) inhibitor
has_related_synonym: EC 3.* (hydrolase) inhibitors
has_related_synonym: EC 3.* inhibitor
has_related_synonym: EC 3.* inhibitors
has_related_synonym: EC 3.*.*.* inhibitor
has_related_synonym: EC 3.*.*.* inhibitors
has_related_synonym: hydrolase (EC 3.*) inhibitor
has_related_synonym: hydrolase (EC 3.*) inhibitors
has_related_synonym: hydrolase inhibitor
has_related_synonym: hydrolase inhibitors
id: CHEBI:76759
comment: Wikipedia:Hydrolase

EC 3.1.* (ester hydrolase) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*).
has_related_synonym: EC 3.1.* (ester hydrolase) inhibitors
has_related_synonym: EC 3.1.* inhibitor
has_related_synonym: EC 3.1.* inhibitors
has_related_synonym: ester hydrolase (EC 3.1.*) inhibitor
has_related_synonym: ester hydrolase (EC 3.1.*) inhibitors
has_related_synonym: ester hydrolase inhibitor
has_related_synonym: ester hydrolase inhibitors
id: CHEBI:76760

EC 3.2.* (glycosylase) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*).
has_related_synonym: EC 3.2.* (glycosylase) inhibitors
has_related_synonym: EC 3.2.* inhibitor
has_related_synonym: EC 3.2.* inhibitors
has_related_synonym: glycosylase (EC 3.2.*) inhibitor
has_related_synonym: glycosylase (EC 3.2.*) inhibitors
has_related_synonym: glycosylase inhibitor
has_related_synonym: glycosylase inhibitors
id: CHEBI:76761

EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
has_related_synonym: EC 3.5.* inhibitor
has_related_synonym: EC 3.5.* inhibitors
id: CHEBI:76764

EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*).
has_related_synonym: EC 3.1.1.* (carboxylic ester hydrolase) inhibitors
has_related_synonym: EC 3.1.1.* inhibitor
has_related_synonym: EC 3.1.1.* inhibitors
has_related_synonym: carboxylic ester hydrolase (EC 3.1.1.*) inhibitor
has_related_synonym: carboxylic ester hydrolase (EC 3.1.1.*) inhibitors
id: CHEBI:76773

EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*).
has_related_synonym: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors
has_related_synonym: EC 3.1.3.* inhibitor
has_related_synonym: EC 3.1.3.* inhibitors
has_related_synonym: inhibitor of phosphoric monoester hydrolase
has_related_synonym: inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)
has_related_synonym: inhibitors of phosphoric monoester hydrolase
has_related_synonym: inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)
has_related_synonym: phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor
has_related_synonym: phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors
has_related_synonym: phosphoric monoester hydrolase inhibitor
has_related_synonym: phosphoric monoester hydrolase inhibitors
id: CHEBI:76775

EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
definition: Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
has_related_synonym: EC 3.4.21.26 (prolyl oligopeptidase) inhibitors
has_related_synonym: EC 3.4.21.26 inhibitor
has_related_synonym: EC 3.4.21.26 inhibitors
has_related_synonym: endoprolylpeptidase inhibitor
has_related_synonym: endoprolylpeptidase inhibitors
has_related_synonym: post-proline cleaving enzyme inhibitor
has_related_synonym: post-proline cleaving enzyme inhibitors
has_related_synonym: post-proline endopeptidase inhibitor
has_related_synonym: post-proline endopeptidase inhibitors
has_related_synonym: proline endopeptidase inhibitor
has_related_synonym: proline endopeptidase inhibitors
has_related_synonym: proline-specific endopeptidase inhibitor
has_related_synonym: proline-specific endopeptidase inhibitors
has_related_synonym: prolyl endopeptidase inhibitor
has_related_synonym: prolyl endopeptidase inhibitors
has_related_synonym: prolyl oligopeptidase (EC 3.4.21.26) inhibitor
has_related_synonym: prolyl oligopeptidase (EC 3.4.21.26) inhibitors
has_related_synonym: prolyl oligopeptidase inhibitor
id: CHEBI:76779

EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*).
has_related_synonym: EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors
has_related_synonym: EC 3.1.26.* inhibitor
has_related_synonym: EC 3.1.26.* inhibitors
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitor
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitors
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters inhibitor
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters inhibitors
id: CHEBI:76785

EC 2.4.2.* (pentosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.* (glycosyltransferase) inhibitor
definition: An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*).
has_related_synonym: EC 2.4.2.* (pentosyltransferase) inhibitors
has_related_synonym: EC 2.4.2.* inhibitor
has_related_synonym: EC 2.4.2.* inhibitors
has_related_synonym: pentosyltransferase (EC 2.4.2.*) inhibitor
has_related_synonym: pentosyltransferase (EC 2.4.2.*) inhibitors
has_related_synonym: pentosyltransferase inhibitor
has_related_synonym: pentosyltransferase inhibitors
id: CHEBI:76790

EC 2.5.1.18 (glutathione transferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of a glutathione transferase (EC 2.5.1.18).
has_related_synonym: EC 2.5.1.18 (glutathione transferase) inhibitors
has_related_synonym: EC 2.5.1.18 inhibitor
has_related_synonym: EC 2.5.1.18 inhibitors
has_related_synonym: RX:glutathione R-transferase inhibitor
has_related_synonym: RX:glutathione R-transferase inhibitors
has_related_synonym: S-(hydroxyalkyl)glutathione lyase inhibitor
has_related_synonym: S-(hydroxyalkyl)glutathione lyase inhibitors
has_related_synonym: glutathione S-alkyl transferase inhibitor
has_related_synonym: glutathione S-alkyl transferase inhibitors
has_related_synonym: glutathione S-alkyltransferase inhibitor
has_related_synonym: glutathione S-alkyltransferase inhibitors
has_related_synonym: glutathione S-aralkyltransferase inhibitor
has_related_synonym: glutathione S-aralkyltransferase inhibitors
has_related_synonym: glutathione S-aryltransferase inhibitor
has_related_synonym: glutathione S-aryltransferase inhibitors
has_related_synonym: glutathione S-transferase inhibitor
has_related_synonym: glutathione S-transferase inhibitors
has_related_synonym: glutathione transferase (EC 2.5.1.18) inhibitor
has_related_synonym: glutathione transferase (EC 2.5.1.18) inhibitors
has_related_synonym: glutathione transferase inhibitor
has_related_synonym: glutathione transferase inhibitors
id: CHEBI:76797

EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
has_related_synonym: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
has_related_synonym: EC 3.5.1.* inhibitor
has_related_synonym: EC 3.5.1.* inhibitors
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
id: CHEBI:76807

sphingomyelin phosphodiesterase inhibitor role
type: Class
subclass of: TXPO_0000559
definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of sphingomyelin phosphodiesterase (EC 3.1.4.12).
has_exact_synonym: EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor
has_exact_synonym: sphingomyelin phosphodiesterase inhibitor

EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
type: Class
subclass of: protein kinase inhibitor
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*).
has_related_synonym: EC 2.7.11.* (protein-serine/threonine kinase) inhibitors
has_related_synonym: EC 2.7.11.* inhibitor
has_related_synonym: EC 2.7.11.* inhibitors
has_related_synonym: protein-serine/threonine kinase (EC 2.7.11.*) inhibitor
has_related_synonym: protein-serine/threonine kinase (EC 2.7.11.*) inhibitors
has_related_synonym: protein-serine/threonine kinase inhibitor
has_related_synonym: protein-serine/threonine kinase inhibitors
id: CHEBI:76812

EC 2.7.7.* (nucleotidyltransferase) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*).
has_related_synonym: EC 2.7.7.* (nucleotidyltransferase) inhibitors
has_related_synonym: inhibitor of nucleotidyltransferases
has_related_synonym: inhibitor of nucleotidyltransferases (EC 2.7.7.*)
has_related_synonym: inhibitors of nucleotidyltransferases
has_related_synonym: inhibitors of nucleotidyltransferases (EC 2.7.7.*)
has_related_synonym: nucleotidyltransferase (EC 2.7.7.*) inhibitor
has_related_synonym: nucleotidyltransferase (EC 2.7.7.*) inhibitors
has_related_synonym: nucleotidyltransferase inhibitor
has_related_synonym: nucleotidyltransferase inhibitors
id: CHEBI:76815

EC 2.7.10.* (protein-tyrosine kinase) inhibitor
type: Class
subclass of: protein kinase inhibitor
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-tyrosine kinase (EC 2.7.10.*).
has_related_synonym: EC 2.7.10.* (protein-tyrosine kinase) inhibitors
has_related_synonym: EC 2.7.10.* inhibitor
has_related_synonym: EC 2.7.10.* inhibitors
has_related_synonym: protein-tyrosine kinase (EC 2.7.10.*) inhibitor
has_related_synonym: protein-tyrosine kinase (EC 2.7.10.*) inhibitors
has_related_synonym: protein-tyrosine kinase inhibitor
has_related_synonym: protein-tyrosine kinase inhibitors
id: CHEBI:76817

EC 5.99.1.* (miscellaneous isomerase) inhibitor
type: Class
subclass of: EC 5.99.* (other isomerases) inhibitor
definition: An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class.
has_related_synonym: EC 5.99.1.* (miscellaneous isomerase) inhibitors
has_related_synonym: EC 5.99.1.* inhibitor
has_related_synonym: EC 5.99.1.* inhibitors
id: CHEBI:76830

EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
definition: An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*).
has_related_synonym: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors
has_related_synonym: EC 2.5.* inhibitor
has_related_synonym: EC 2.5.* inhibitors
has_related_synonym: non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor
has_related_synonym: non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors
id: CHEBI:76834

EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
type: Class
subclass of: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
definition: An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*).
has_related_synonym: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors
has_related_synonym: EC 1.1.1.* inhibitor
has_related_synonym: EC 1.1.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors
id: CHEBI:76835

EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
type: Class
subclass of: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
definition: An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*).
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors
has_related_synonym: EC 1.13.11.* inhibitor
has_related_synonym: EC 1.13.11.* inhibitors
has_related_synonym: oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor
has_related_synonym: oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors
id: CHEBI:76837

EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*).
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
has_related_synonym: EC 1.14.14.* inhibitor
has_related_synonym: EC 1.14.14.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors
id: CHEBI:76838

EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any enzyme in the EC 1.14.99.* (miscellaneous) category.
has_related_synonym: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
has_related_synonym: EC 1.14.99.* inhibitor
has_related_synonym: EC 1.14.99.* inhibitors
has_related_synonym: miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor
has_related_synonym: miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitors
id: CHEBI:76840

EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*).
has_related_synonym: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors
has_related_synonym: EC 1.14.13.* inhibitor
has_related_synonym: EC 1.14.13.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors
id: CHEBI:76841

EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor
type: Class
subclass of: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the activity of any such enzyme that uses a disulfide as acceptor (EC 1.17.4.*).
has_related_synonym: EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitors
has_related_synonym: EC 1.17.4.* inhibitor
has_related_synonym: EC 1.17.4.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors
id: CHEBI:76848

EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the function of any such enzyme that uses oxygen as acceptor (EC 1.17.3.*).
has_related_synonym: EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.17.3.* inhibitor
has_related_synonym: EC 1.17.3.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors
id: CHEBI:76850

EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
definition: An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.2.1.*).
has_related_synonym: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.2.1.* inhibitor
has_related_synonym: EC 1.2.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitors
id: CHEBI:76852

EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
definition: An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*).
has_related_synonym: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.2.3.* inhibitor
has_related_synonym: EC 1.2.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors
id: CHEBI:76853

EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the function of any such enzyme in the EC 1.3.98.* (with other, known, acceptors) category.
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitors
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitors
has_related_synonym: EC 1.3.98.* inhibitor
has_related_synonym: EC 1.3.98.* inhibitors
has_related_synonym: oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitors
id: CHEBI:76858

EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
definition: An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*).
has_related_synonym: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.5.1.* inhibitor
has_related_synonym: EC 1.5.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors
id: CHEBI:76863

EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
type: Class
subclass of: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
definition: An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*).
has_related_synonym: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors
has_related_synonym: EC 1.6.5.* inhibitor
has_related_synonym: EC 1.6.5.* inhibitors
has_related_synonym: oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors
id: CHEBI:76866

EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
definition: An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*).
has_related_synonym: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.8.1.* inhibitor
has_related_synonym: EC 1.8.1.* inhibitors
has_related_synonym: oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor
has_related_synonym: oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors
id: CHEBI:76869

EC 2.1.1.* (methyltransferases) inhibitor
type: Class
subclass of: EC 2.1.* (C1-transferase) inhibitor
definition: An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
has_related_synonym: EC 2.1.1.* (methyltransferase) inhibitor
has_related_synonym: EC 2.1.1.* (methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.* (methyltransferases) inhibitors
has_related_synonym: EC 2.1.1.* inhibitor
has_related_synonym: EC 2.1.1.* inhibitors
has_related_synonym: methyltransferase (EC 2.1.1.*) inhibitor
has_related_synonym: methyltransferase (EC 2.1.1.*) inhibitors
id: CHEBI:76871

EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
type: Class
subclass of: EC 2.3.* (acyltransferase) inhibitor
definition: An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*).
has_related_synonym: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors
has_related_synonym: EC 2.3.1.* inhibitor
has_related_synonym: EC 2.3.1.* inhibitors
has_related_synonym: acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor
has_related_synonym: acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors
id: CHEBI:76878

EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
type: Class
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
definition: An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*).
has_related_synonym: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors
has_related_synonym: EC 3.6.3.* inhibitor
has_related_synonym: EC 3.6.3.* inhibitors
has_related_synonym: acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor
has_related_synonym: acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors
id: CHEBI:76895

EC 1.14.14.1 (unspecific monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
definition: An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1).
has_related_synonym: EC 1.14.14.1 (unspecific monooxygenase) inhibitors
has_related_synonym: EC 1.14.14.1 inhibitor
has_related_synonym: EC 1.14.14.1 inhibitors
has_related_synonym: aryl hydrocarbon hydroxylase inhibitor
has_related_synonym: aryl hydrocarbon hydroxylase inhibitors
has_related_synonym: aryl-4-monooxygenase inhibitor
has_related_synonym: aryl-4-monooxygenase inhibitors
has_related_synonym: flavoprotein monooxygenase inhibitor
has_related_synonym: flavoprotein monooxygenase inhibitors
has_related_synonym: flavoprotein-linked monooxygenase inhibitor
has_related_synonym: flavoprotein-linked monooxygenase inhibitors
has_related_synonym: microsomal P-450 inhibitor
has_related_synonym: microsomal P-450 inhibitors
has_related_synonym: microsomal monooxygenase inhibitor
has_related_synonym: microsomal monooxygenase inhibitors
has_related_synonym: substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor
has_related_synonym: substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors
has_related_synonym: unspecific monooxygenase (EC 1.14.14.1) inhibitor
has_related_synonym: unspecific monooxygenase (EC 1.14.14.1) inhibitors
has_related_synonym: unspecific monooxygenase inhibitor
has_related_synonym: unspecific monooxygenase inhibitors
has_related_synonym: xenobiotic monooxygenase inhibitor
has_related_synonym: xenobiotic monooxygenase inhibitors
id: CHEBI:76898

EC 4.2.1.* (hydro-lyases) inhibitor
type: Class
subclass of: EC 4.2.* (C-O lyase) inhibitor
definition: An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*).
has_related_synonym: EC 4.2.1.* (hydro-lyase) inhibitor
has_related_synonym: EC 4.2.1.* (hydro-lyase) inhibitors
has_related_synonym: EC 4.2.1.* (hydro-lyases) inhibitors
has_related_synonym: EC 4.2.1.* inhibitor
has_related_synonym: EC 4.2.1.* inhibitors
has_related_synonym: hydro-lyase (EC 4.2.1.*) inhibitor
has_related_synonym: hydro-lyase (EC 4.2.1.*) inhibitors
id: CHEBI:76907

pathway inhibitor
type: Class
subclass of: enzyme inhibitor
subclass of: TXPO_0003720
definition: An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.
definition: An enzyme inhibitor that interferes with one or more steps in a signaling or metabolic pathway.
has_related_synonym: metabolic pathway inhibitor
has_related_synonym: metabolic pathway inhibitors
has_related_synonym: pathway inhibitors
id: CHEBI:76932

fungal metabolite
type: Class
subclass of: eukaryotic metabolite
definition: Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
has_related_synonym: fungal metabolites
id: CHEBI:76946

Penicillium metabolite
type: Class
subclass of: fungal metabolite
definition: Any fungal metabolite produced during a metabolic reaction in Penicillium.
has_related_synonym: Penicillium metabolites
id: CHEBI:76964

human xenobiotic metabolite
type: Class
subclass of: xenobiotic metabolite
subclass of: human metabolite
definition: Any human metabolite produced by metabolism of a xenobiotic compound in humans.
has_related_synonym: human xenobiotic metabolites
id: CHEBI:76967

bacterial metabolite
type: Class
subclass of: prokaryotic metabolite
definition: Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
id: CHEBI:76969

Escherichia coli metabolite
type: Class
subclass of: bacterial metabolite
definition: Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
has_related_synonym: E.coli metabolite
has_related_synonym: E.coli metabolites
has_related_synonym: Escherichia coli metabolites
id: CHEBI:76971

aryl hydrocarbon receptor antagonist
type: Class
subclass of: antagonist
definition: An antagonist that binds to and inactivates aryl hydrocarbon receptors (AhRs).
has_exact_synonym: AhR antagonist
has_related_synonym: AhR receptor antagonist

EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*).
has_related_synonym: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors
has_related_synonym: EC 1.3.5.* inhibitor
has_related_synonym: EC 1.3.5.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
has_related_synonym: oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors
id: CHEBI:77102

EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor
type: Class
subclass of: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
definition: An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2.
has_related_synonym: (S)-dihydroorotate:(acceptor) oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:(acceptor) oxidoreductase inhibitors
has_related_synonym: (S)-dihydroorotate:acceptor oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:acceptor oxidoreductase inhibitors
has_related_synonym: (S)-dihydroorotate:quinone oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:quinone oxidoreductase inhibitors
has_related_synonym: DHOD inhibitor
has_related_synonym: DHOD inhibitors
has_related_synonym: DHODH inhibitor
has_related_synonym: DHODH inhibitors
has_related_synonym: DHOdehase inhibitor
has_related_synonym: DHOdehase inhibitors
has_related_synonym: EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitor
has_related_synonym: EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitors
has_related_synonym: EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitors
has_related_synonym: EC 1.3.5.2 inhibitor
has_related_synonym: EC 1.3.5.2 inhibitors
has_related_synonym: dihydroorotate:ubiquinone oxidoreductase inhibitor
has_related_synonym: dihydroorotate:ubiquinone oxidoreductase inhibitors
id: CHEBI:77103

EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor
type: Class
subclass of: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
definition: An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme using a cytochrome as acceptor (EC 1.10.2.*).
has_related_synonym: EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitors
has_related_synonym: EC 1.10.2.* inhibitor
has_related_synonym: EC 1.10.2.* inhibitors
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
has_related_synonym: oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitor
has_related_synonym: oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitors
id: CHEBI:77105

EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor
type: Class
subclass of: EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor
definition: An EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor that interferes with the action of quinol--cytochrome-c reductase (EC 1.10.2.2).
has_related_synonym: EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitors
has_related_synonym: EC 1.10.2.2 inhibitor
has_related_synonym: EC 1.10.2.2 inhibitors
has_related_synonym: inhibitor of quinol--cytochrome-c reductase (EC 1.10.2.2)
has_related_synonym: inhibitors of quinol--cytochrome-c reductase (EC 1.10.2.2)
has_related_synonym: quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitor
has_related_synonym: quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors
id: CHEBI:77106

IkappaB kinase inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).
database_cross_reference: Wikipedia:IkappaB_kinase
has_exact_synonym: EC 2.7.11.10 (IkappaB kinase) inhibitor
has_related_synonym: ATP:[IkappaB protein] phosphotransferase inhibitor
has_related_synonym: IKK inhibitor
has_related_synonym: IkappaB kinase inhibitor

androstane receptor agonist
type: Class
subclass of: agonist
definition: An agonist that selectively binds to and activates androstane receptors.
database_cross_reference: Wikipedia:Constitutive_androstane_receptor
has_related_synonym: CAR agonist
has_related_synonym: constitutive androstane receptor agonist

EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
type: Class
subclass of: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
definition: An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12).
has_related_synonym: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
has_related_synonym: EC 1.8.1.12 inhibitor
has_related_synonym: EC 1.8.1.12 inhibitors
has_related_synonym: N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor
has_related_synonym: N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors
has_related_synonym: NADPH2:trypanothione oxidoreductase inhibitor
has_related_synonym: NADPH2:trypanothione oxidoreductase inhibitors
has_related_synonym: NADPH:trypanothione oxidoreductase inhibitor
has_related_synonym: NADPH:trypanothione oxidoreductase inhibitors
has_related_synonym: trypanothione reductase inhibitor
has_related_synonym: trypanothione reductase inhibitors
has_related_synonym: trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor
has_related_synonym: trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors
has_related_synonym: trypanothione:NADP(+) oxidoreductase inhibitor
has_related_synonym: trypanothione:NADP(+) oxidoreductase inhibitors
id: CHEBI:77402

p53 activator
type: Class
subclass of: TXPO_0003714
definition: A role played by the entity that activates p53.

human metabolite
type: Class
subclass of: mammalian metabolite
definition: Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
has_related_synonym: H. sapiens metabolite
has_related_synonym: H. sapiens metabolites
has_related_synonym: Homo sapiens metabolite
has_related_synonym: Homo sapiens metabolites
id: CHEBI:77746

EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44).
has_related_synonym: ATP phosphohydrolase (steroid-exporting) inhibitor
has_related_synonym: ATP phosphohydrolase (steroid-exporting) inhibitors
has_related_synonym: ATP phosphohydrolase (xenobiotic-exporting) inhibitor
has_related_synonym: ATP phosphohydrolase (xenobiotic-exporting) inhibitors
has_related_synonym: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors
has_related_synonym: EC 3.6.3.44 inhibitor
has_related_synonym: EC 3.6.3.44 inhibitors
has_related_synonym: MDR protein inhibitor
has_related_synonym: MDR protein inhibitors
has_related_synonym: P-glycoprotein inhibitor
has_related_synonym: P-glycoprotein inhibitors
has_related_synonym: PDR protein inhibitor
has_related_synonym: PDR protein inhibitors
has_related_synonym: multidrug-resistance protein inhibitor
has_related_synonym: multidrug-resistance protein inhibitors
has_related_synonym: pleiotropic-drug-resistance protein inhibitor
has_related_synonym: pleiotropic-drug-resistance protein inhibitors
has_related_synonym: steroid-transporting ATPase inhibitor
has_related_synonym: steroid-transporting ATPase inhibitors
has_related_synonym: xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor
has_related_synonym: xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors
has_related_synonym: xenobiotic-transporting ATPase inhibitor
has_related_synonym: xenobiotic-transporting ATPase inhibitors
id: CHEBI:77748

oxandrolone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anabolic agent
subclass of: Restriction
  on property: has role
  some values from: androgen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: Beilstein:5480667
database_cross_reference: DrugBank:DB00621
database_cross_reference: Drug_Central:2011
has_exact_synonym: 17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
has_exact_synonym: Oxandrolone
has_related_synonym: oxandrolona
has_related_synonym: oxandrolone
has_related_synonym: oxandrolonum
id: CHEBI:7820

Beilstein
type: Axiom
annotated source: oxandrolone
annotated property: database_cross_reference
annotated target: Beilstein:5480667

DrugCentral
type: Axiom
annotated source: oxandrolone
annotated property: database_cross_reference
annotated target: Drug_Central:2011

environmental contaminant
type: Class
subclass of: chemical role
definition: Any minor or unwanted substance introduced into the environment that can have undesired effects.
has_related_synonym: environmental contaminants
id: CHEBI:78298

EC 3.1.1.1 (carboxylesterase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
definition: Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).
has_related_synonym: Alpha-carboxylesterase inhibitor
has_related_synonym: Alpha-carboxylesterase inhibitors
has_related_synonym: Beta-esterase inhibitor
has_related_synonym: Beta-esterase inhibitors
has_related_synonym: EC 3.1.1.1 (carboxylesterase) inhibitors
has_related_synonym: ali-esterase inhibitor
has_related_synonym: ali-esterase inhibitors
has_related_synonym: butyrate esterase inhibitor
has_related_synonym: butyrate esterase inhibitors
has_related_synonym: butyryl esterase inhibitor
has_related_synonym: butyryl esterase inhibitors
has_related_synonym: carboxyl ester hydrolase inhibitor
has_related_synonym: carboxyl ester hydrolase inhibitors
has_related_synonym: carboxylate esterase inhibitor
has_related_synonym: carboxylate esterase inhibitors
has_related_synonym: carboxylesterase inhibitor
has_related_synonym: carboxylesterase inhibitors
has_related_synonym: carboxylic acid esterase inhibitor
has_related_synonym: carboxylic acid esterase inhibitors
has_related_synonym: carboxylic esterase inhibitor
has_related_synonym: carboxylic esterase inhibitors
has_related_synonym: carboxylic-ester hydrolase inhibitor
has_related_synonym: carboxylic-ester hydrolase inhibitors
has_related_synonym: cocaine esterase inhibitor
has_related_synonym: cocaine esterase inhibitors
has_related_synonym: esterase A inhibitor
has_related_synonym: esterase A inhibitors
has_related_synonym: esterase B inhibitor
has_related_synonym: esterase B inhibitors
has_related_synonym: esterase D inhibitor
has_related_synonym: esterase D inhibitors
has_related_synonym: methylbutyrase inhibitor
has_related_synonym: methylbutyrase inhibitors
has_related_synonym: methylbutyrate esterase inhibitor
has_related_synonym: methylbutyrate esterase inhibitors
has_related_synonym: monobutyrase inhibitor
has_related_synonym: monobutyrase inhibitors
has_related_synonym: nonspecific carboxylesterase inhibitor
has_related_synonym: nonspecific carboxylesterase inhibitors
has_related_synonym: procaine esterase inhibitor
has_related_synonym: procaine esterase inhibitors
has_related_synonym: propionyl esterase inhibitor
has_related_synonym: propionyl esterase inhibitors
has_related_synonym: serine esterase inhibitor
has_related_synonym: serine esterase inhibitors
has_related_synonym: triacetin esterase inhibitor
has_related_synonym: triacetin esterase inhibitors
has_related_synonym: vitamin A esterase inhibitor
has_related_synonym: vitamin A esterase inhibitors
id: CHEBI:78444

oxymetholone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anabolic agent
subclass of: Restriction
  on property: has role
  some values from: androgen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.
database_cross_reference: CAS:434-07-1
database_cross_reference: PMID:11071398
database_cross_reference: PMID:1125426
database_cross_reference: PMID:11440282
database_cross_reference: PMID:21860526
database_cross_reference: Reaxys:2623806
has_exact_synonym: 17beta-hydroxy-2-(hydroxymethylidene)-17-methyl-5alpha-androstan-3-one
has_related_synonym: (5alpha,17beta)-17-hydroxy-2-(hydroxymethylidene)-17-methylandrostan-3-one
has_related_synonym: 17alpha-methyl-2-hydroxymethylene-17-hydroxy-5alpha-androstan-3-one
has_related_synonym: 17beta-hydroxy-2-(hydroxymethylene)-17-methyl-5alpha-androstan-3-one
has_related_synonym: 2-hydroxymethylene-17alpha-methyl-17beta-hydroxy-5alpha-androstan-3-one
has_related_synonym: 2-hydroxymethylene-17alpha-methyl-5alpha-androstan-17beta-ol-3-one
has_related_synonym: 2-hydroxymethylene-17alpha-methyldihydrotestosterone
has_related_synonym: 4,5alpha-dihydro-2-hydroxymethylene-17alpha-methyltestosterone
has_related_synonym: Adroyd
has_related_synonym: Anadrol-50
has_related_synonym: Anapolon
has_related_synonym: Nastenon
has_related_synonym: Pardroyd
has_related_synonym: Plenastril
has_related_synonym: Protanabol
has_related_synonym: Synasteron
has_related_synonym: oximetolona
has_related_synonym: oxymetholone
has_related_synonym: oxymetholonum
id: CHEBI:7864

ChemIDplus
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: CAS:434-07-1

NIST Chemistry WebBook
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: CAS:434-07-1

Europe PMC
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: PMID:11071398

Europe PMC
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: PMID:1125426

Europe PMC
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: PMID:11440282

Europe PMC
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: PMID:21860526

Reaxys
type: Axiom
annotated source: oxymetholone
annotated property: database_cross_reference
annotated target: Reaxys:2623806

17β-estradiol 17-glucosiduronic acid
type: Class
subclass of: steroid
definition: A steroid glucosiduronic acid that consists of 17β-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage.
database_cross_reference: InChIKey:MTKNDAQYHASLID-QXYWQCSFSA-N
database_cross_reference: Nikkaji:J386.923G
database_cross_reference: http://purl.bioontology.org/ontology/MESH/C025483
has_exact_synonym: Estradiol-17beta-glucuronide

pemoline
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: central nervous system stimulant
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
database_cross_reference: CAS:2152-34-3
database_cross_reference: DrugBank:DB01230
database_cross_reference: Drug_Central:2075
database_cross_reference: LINCS:LSM-5159
database_cross_reference: PMID:11216184
database_cross_reference: PMID:2210262
database_cross_reference: PMID:2303976
database_cross_reference: PMID:2388127
database_cross_reference: PMID:4021028
database_cross_reference: PMID:641739
database_cross_reference: PMID:772696
database_cross_reference: Reaxys:151559
has_exact_synonym: 2-amino-5-phenyl-1,3-oxazol-4(5H)-one
has_related_synonym: 2-Amino-5-phenyl-4(5H)-oxazolone
has_related_synonym: 2-imino-4-keto-5-phenyltetrahydrooxazole
has_related_synonym: 2-imino-5-phenyl-4-oxazolidinone
has_related_synonym: 5-phenyl-2-imino-4-oxazolidinone
has_related_synonym: 5-phenyl-2-imino-4-oxooxazolidine
has_related_synonym: 5-phenylisohydantion
has_related_synonym: Azoxodon
has_related_synonym: Betanamin
has_related_synonym: Cylert
has_related_synonym: Dantromin
has_related_synonym: Deltamine
has_related_synonym: Hyton
has_related_synonym: Myamin
has_related_synonym: Nitan
has_related_synonym: Notair
has_related_synonym: pemolina
has_related_synonym: pemoline
has_related_synonym: pemolinum
has_related_synonym: pheniminooxazolidinone
has_related_synonym: phenylisohydantoin
has_related_synonym: phenylpseudohydantoin
id: CHEBI:7953

ChemIDplus
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: CAS:2152-34-3

NIST Chemistry WebBook
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: CAS:2152-34-3

DrugCentral
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: Drug_Central:2075

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:11216184

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:2210262

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:2303976

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:2388127

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:4021028

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:641739

Europe PMC
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: PMID:772696

Reaxys
type: Axiom
annotated source: pemoline
annotated property: database_cross_reference
annotated target: Reaxys:151559

phenobarbital
type: Class
subclass of: barbiturates
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
formula: C12H12N2O3
smiles: CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
database_cross_reference: CAS:50-06-6
database_cross_reference: CHEBI:8069
database_cross_reference: DrugBank:DB01174
database_cross_reference: Open TG-Gates compound_id=00004
database_cross_reference: https://livertox.nlm.nih.gov//Phenobarbital.htm

phenytoin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has role
  some values from: sodium channel blocker
subclass of: Restriction
  on property: has role
  some values from: teratogenic agent
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
database_cross_reference: Beilstein:384532
database_cross_reference: CAS:57-41-0
database_cross_reference: DrugBank:DB00252
database_cross_reference: Drug_Central:2152
database_cross_reference: LINCS:LSM-5663
database_cross_reference: PMID:10698828
database_cross_reference: PMID:12952753
database_cross_reference: PMID:15246836
database_cross_reference: PMID:15744730
database_cross_reference: PMID:16303054
database_cross_reference: PMID:7105825
database_cross_reference: PMID:7602118
database_cross_reference: PMID:9186244
database_cross_reference: Reaxys:384532
has_exact_synonym: 5,5-diphenylimidazolidine-2,4-dione
has_related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione
has_related_synonym: 5,5-diphenylimidazolidine-2,4-dione
has_related_synonym: 5,5-diphenyltetrahydro-1H-2,4-imidazoledione
has_related_synonym: DILANTIN
has_related_synonym: PHENTYTOIN
has_related_synonym: fenitoina
has_related_synonym: phenytoin
has_related_synonym: phenytoine
has_related_synonym: phenytoinum
id: CHEBI:8107

Beilstein
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: Beilstein:384532

ChemIDplus
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: CAS:57-41-0

DrugCentral
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: Drug_Central:2152

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:10698828

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:12952753

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:15246836

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:15744730

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:16303054

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:7105825

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:7602118

Europe PMC
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: PMID:9186244

Reaxys
type: Axiom
annotated source: phenytoin
annotated property: database_cross_reference
annotated target: Reaxys:384532

crustacean metabolite
type: Class
subclass of: animal metabolite
definition: An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
has_related_synonym: crustacean metabolites
id: CHEBI:83039

Daphnia magna metabolite
type: Class
subclass of: Daphnia metabolite
definition: A Daphnia metabolite produced by the species Daphnia magna.
has_related_synonym: Daphnia magna metabolites
id: CHEBI:83056

Daphnia metabolite
type: Class
subclass of: crustacean metabolite
definition: A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia
has_related_synonym: Daphnia metabolites
id: CHEBI:83057

sterol biosynthesis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
definition: Any compound that inhibits the biosynthesis of any sterol.
has_related_synonym: sterol biosynthesis inhibitors
id: CHEBI:83317

hepatic steatosis inducing agent
type: Class
subclass of: hepatotoxic agent
definition: Any hepatotoxic agent capable of inducing liver steatosis or fatty liver disease.
has_related_synonym: hepatic steatosis inducing drugs

eltrombopag
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: thrombopoietin receptor agonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
database_cross_reference: CAS:496775-61-2
database_cross_reference: Drug_Central:4399
database_cross_reference: PMID:24433306
database_cross_reference: PMID:25063763
database_cross_reference: PMID:25170628
database_cross_reference: PMID:25400215
database_cross_reference: PMID:25578417
database_cross_reference: PMID:25700916
has_exact_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
has_related_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid
id: CHEBI:85010

ChemIDplus
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: CAS:496775-61-2

DrugCentral
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: Drug_Central:4399

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:24433306

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:25063763

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:25170628

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:25400215

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:25578417

Europe PMC
type: Axiom
annotated source: eltrombopag
annotated property: database_cross_reference
annotated target: PMID:25700916

thrombopoietin receptor agonist
type: Class
subclass of: agonist
definition: An agonist that selectively binds to and activates the thrombopoietin receptor [myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110)].
has_related_synonym: TPO receptor agonist
has_related_synonym: TPO receptor agonists
has_related_synonym: thrombopoietin receptor agonists
id: CHEBI:85012

antifungal drug
type: Class
subclass of: antifungal agent
definition: Any antifungal agent used to prevent or treat fungal infections in humans or animals.
database_cross_reference: Wikipedia:Antifungal

antifungal agrochemical
type: Class
subclass of: pesticide
definition: Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
has_related_synonym: agrichemical fungicide
has_related_synonym: agrichemical fungicides
has_related_synonym: agrochemical fungicide
has_related_synonym: agrochemical fungicides
has_related_synonym: anti-fungal agrichemical
has_related_synonym: anti-fungal agrichemicals
has_related_synonym: anti-fungal agrochemical
has_related_synonym: anti-fungal agrochemicals
has_related_synonym: antifungal agrichemical
has_related_synonym: antifungal agrichemicals
has_related_synonym: antifungal agrochemicals
id: CHEBI:86328

drug allergen
type: Class
subclass of: drug
subclass of: allergen
definition: Any drug which causes the onset of an allergic reaction.
has_related_synonym: allergenic drug
id: CHEBI:88188

autophagy inhibitor
type: Class
subclass of: TXPO_0002629
subclass of: Restriction
  on property: capable of negatively regulating
  some values from: autophagy
definition: Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
database_cross_reference: PMID:24830781
database_cross_reference: PMID:25727221
database_cross_reference: PMID:25793774
database_cross_reference: PMID:25896709
database_cross_reference: Wikipedia:Autophagy
has_related_synonym: autophagocytosis inhibitor

Riluzole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
database_cross_reference: CAS:1744-22-5
database_cross_reference: Drug_Central:2382
database_cross_reference: LINCS:LSM-2471
has_exact_synonym: Riluzole
has_related_synonym: 6-Trifluoromethoxybenzothiazol-2-ylamine
has_related_synonym: RP-54274
has_related_synonym: RP54274
has_related_synonym: rilutek
has_related_synonym: rilutor
has_related_synonym: riluzole HCl
has_related_synonym: riluzole hydrochloride
id: CHEBI:8863

DrugCentral
type: Axiom
annotated source: Riluzole
annotated property: database_cross_reference
annotated target: Drug_Central:2382

lysophosphatidylglycerol
type: Class
subclass of: glycerophosphoglycerols
definition: A glycerophosphoglycerol resulting from partial hydrolysis of a phosphatidylglycerol, which removes one of the fatty acid groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.
has_exact_synonym: monoacylglycerophosphoglycerol

receptor modulator
type: Class
subclass of: drug
definition: A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
has_related_synonym: receptor modulators
id: CHEBI:90710

purinergic receptor P2 antagonist
type: Class
subclass of: antagonist
definition: An antagonist at purinergic P2 receptors
has_related_synonym: P2 antagonist
has_related_synonym: P2 antagonists
has_related_synonym: non-selective P2 purinergic antagonist
has_related_synonym: non-selective P2 purinergic antagonists
has_related_synonym: purinergic receptor P2 antagonists
id: CHEBI:91079

sulfasalazine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: gastrointestinal drug
subclass of: Restriction
  on property: has role
  some values from: EC 2.5.1.18 (glutathione transferase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
database_cross_reference: Beilstein:356241
database_cross_reference: Beilstein:8132868
database_cross_reference: CAS:599-79-1
database_cross_reference: DrugBank:DB00795
database_cross_reference: Gmelin:2666050
database_cross_reference: PMID:11362329
database_cross_reference: PMID:11485124
database_cross_reference: PMID:11587223
database_cross_reference: PMID:14981898
database_cross_reference: PMID:15248210
database_cross_reference: PMID:16322111
database_cross_reference: PMID:17386570
database_cross_reference: PMID:2434548
database_cross_reference: PMID:7720170
database_cross_reference: Reaxys:8132868
has_exact_synonym: 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
has_exact_synonym: Sulfasalazine
has_related_synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
has_related_synonym: 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid
has_related_synonym: 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
has_related_synonym: 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid
has_related_synonym: 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
has_related_synonym: 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid
has_related_synonym: Azulfidine
has_related_synonym: Salazosulfapiridina
has_related_synonym: Salazosulfapyridine
has_related_synonym: Salazosulfapyridinum
has_related_synonym: Salicylazosulfapyridine
has_related_synonym: Sulfasalazina
has_related_synonym: Sulfasalazinum
has_related_synonym: sulfasalazine
id: CHEBI:9334

Beilstein
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: Beilstein:356241

Beilstein
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: Beilstein:8132868

ChemIDplus
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: CAS:599-79-1

Gmelin
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: Gmelin:2666050

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:11362329

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:11485124

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:11587223

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:14981898

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:15248210

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:16322111

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:17386570

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:2434548

Europe PMC
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: PMID:7720170

Reaxys
type: Axiom
annotated source: sulfasalazine
annotated property: database_cross_reference
annotated target: Reaxys:8132868

sulfathiazole
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antiinfective agent
subclass of: Restriction
  on property: has role
  some values from: xenobiotic
subclass of: Restriction
  on property: has role
  some values from: EC 2.5.1.15 (dihydropteroate synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: environmental contaminant
subclass of: Restriction
  on property: has role
  some values from: drug allergen
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.
database_cross_reference: Beilstein:226178
database_cross_reference: CAS:72-14-0
database_cross_reference: DrugBank:DB06147
database_cross_reference: Drug_Central:2527
database_cross_reference: Gmelin:218965
database_cross_reference: LINCS:LSM-5327
database_cross_reference: PMID:11431418
database_cross_reference: PMID:7486915
database_cross_reference: Reaxys:226178
has_exact_synonym: 4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide
has_related_synonym: 2-(Sulfanilylamino)thiazole
has_related_synonym: 2-(p-Aminobenzenesulfonamido)thiazole
has_related_synonym: 2-(p-Aminobenzenesulphonamido)thiazole
has_related_synonym: 2-Sulfanilamidothiazol
has_related_synonym: 2-Sulfanilamidothiazole
has_related_synonym: 2-Sulfonamidothiazole
has_related_synonym: 4-Amino-N-2-thiazolylbenzenesulfonamide
has_related_synonym: N(1)-2-Thiazolylsulfanilamide
has_related_synonym: Sulfanilamidothiazole
has_related_synonym: Sulfatiazol
has_related_synonym: Sulphathiazole
has_related_synonym: sulfathiazol
has_related_synonym: sulfathiazole
has_related_synonym: sulfathiazolum
has_related_synonym: sulfthiazole
id: CHEBI:9337

Beilstein
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: Beilstein:226178

ChemIDplus
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: CAS:72-14-0

NIST Chemistry WebBook
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: CAS:72-14-0

DrugCentral
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: Drug_Central:2527

Gmelin
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: Gmelin:218965

Europe PMC
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: PMID:11431418

Europe PMC
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: PMID:7486915

Reaxys
type: Axiom
annotated source: sulfathiazole
annotated property: database_cross_reference
annotated target: Reaxys:226178

sulindac
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: non-steroidal anti-inflammatory drug
subclass of: Restriction
  on property: has role
  some values from: analgesic
subclass of: Restriction
  on property: has role
  some values from: non-narcotic analgesic
subclass of: Restriction
  on property: has role
  some values from: antipyretic
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: prodrug
subclass of: Restriction
  on property: has role
  some values from: tocolytic agent
subclass of: Restriction
  on property: has role
  some values from: apoptosis inducer
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
smiles: CC1=C(CC(O)=O)c2cc(F)ccc2C\1=C/c1ccc(cc1)S(C)=O
database_cross_reference: ATC:M01AB02
database_cross_reference: Beilstein:2951842
database_cross_reference: CAS:38194-50-2
database_cross_reference: DrugBank:DB00605
database_cross_reference: Drug_Central:2534
database_cross_reference: PMID:11569947
database_cross_reference: PMID:11927004
database_cross_reference: PMID:12406542
database_cross_reference: PMID:15020200
database_cross_reference: PMID:15123337
database_cross_reference: PMID:19884509
database_cross_reference: PMID:23689354
database_cross_reference: PMID:23804703
database_cross_reference: Reaxys:2951842
database_cross_reference: Wikipedia:Sulindac
has_exact_synonym: Sulindac
has_exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
has_related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
has_related_synonym: Clinoril
has_related_synonym: Sulindacum
has_related_synonym: cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
has_related_synonym: cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
has_related_synonym: sulindac
has_related_synonym: sulindaco
id: CHEBI:9352

Beilstein
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: Beilstein:2951842

ChemIDplus
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: CAS:38194-50-2

NIST Chemistry WebBook
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: CAS:38194-50-2

DrugCentral
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: Drug_Central:2534

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:11569947

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:11927004

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:12406542

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:15020200

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:15123337

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:19884509

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:23689354

Europe PMC
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: PMID:23804703

Reaxys
type: Axiom
annotated source: sulindac
annotated property: database_cross_reference
annotated target: Reaxys:2951842

terbinafine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: P450 inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 1.14.13.132 (squalene monooxygenase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: sterol biosynthesis inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.
database_cross_reference: CAS:91161-71-6
database_cross_reference: DrugBank:DB00857
database_cross_reference: Drug_Central:2597
database_cross_reference: PMID:23750489
database_cross_reference: PMID:23802806
database_cross_reference: PMID:23841559
database_cross_reference: PMID:23895037
database_cross_reference: PMID:24126579
database_cross_reference: PMID:24352873
database_cross_reference: PMID:24389279
database_cross_reference: PMID:24410098
database_cross_reference: PMID:24447130
database_cross_reference: PMID:24452843
database_cross_reference: PMID:24477462
database_cross_reference: PMID:24490976
database_cross_reference: PMID:24497012
database_cross_reference: PMID:24533442
database_cross_reference: PMID:24563892
database_cross_reference: PMID:24576265
database_cross_reference: PMID:24581620
database_cross_reference: PMID:24588014
database_cross_reference: Reaxys:4256376
has_exact_synonym: (2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine
has_exact_synonym: terbinafine
has_related_synonym: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine
has_related_synonym: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine
has_related_synonym: terbinafina
has_related_synonym: terbinafine
has_related_synonym: terbinafinum
id: CHEBI:9448

ChemIDplus
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: CAS:91161-71-6

DrugCentral
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: Drug_Central:2597

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:23750489

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:23802806

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:23841559

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:23895037

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24126579

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24352873

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24389279

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24410098

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24447130

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24452843

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24477462

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24490976

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24497012

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24533442

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24563892

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24576265

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24581620

Europe PMC
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: PMID:24588014

Reaxys
type: Axiom
annotated source: terbinafine
annotated property: database_cross_reference
annotated target: Reaxys:4256376

orlistat
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: EC 3.1.1.3 (triacylglycerol lipase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: EC 2.3.1.85 (fatty acid synthase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: anti-obesity agent
subclass of: Restriction
  on property: has role
  some values from: bacterial metabolite
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
database_cross_reference: CAS:96829-58-2
database_cross_reference: Drug_Central:1996
database_cross_reference: LINCS:LSM-5724
database_cross_reference: PMID:27793869
database_cross_reference: PMID:28097013
database_cross_reference: PMID:28191026
database_cross_reference: PMID:28260907
database_cross_reference: PMID:28387458
database_cross_reference: PMID:28559211
database_cross_reference: PMID:28588183
database_cross_reference: PMID:28624425
database_cross_reference: Reaxys:3658031
has_exact_synonym: (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl N-formyl-L-leucinate
has_related_synonym: (-)-tetrahydrolipostatin
has_related_synonym: (2S)-2-formamido-4-methylpentanoic acid [(2S)-1-[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]tridecan-2-yl] ester
has_related_synonym: Alli
has_related_synonym: N-formyl-L-leucine (1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl}dodecyl ester
has_related_synonym: Ro-18-0647
has_related_synonym: Xenical
has_related_synonym: orlipastat
has_related_synonym: orlistat
has_related_synonym: orlistatum
id: CHEBI:94686

ChemIDplus
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: CAS:96829-58-2

DrugCentral
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: CAS:96829-58-2

DrugCentral
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: Drug_Central:1996

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:27793869

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28097013

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28191026

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28260907

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28387458

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28559211

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28588183

Europe PMC
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: PMID:28624425

Reaxys
type: Axiom
annotated source: orlistat
annotated property: database_cross_reference
annotated target: Reaxys:3658031

thapsigargin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: calcium channel blocker
definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
formula: C34H50O12
database_cross_reference: CAS:67526-95-8
has_exact_synonym: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate

ticlopidine
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: fibrin modulating drug
subclass of: Restriction
  on property: has role
  some values from: hematologic agent
subclass of: Restriction
  on property: has role
  some values from: anticoagulant
subclass of: Restriction
  on property: has role
  some values from: platelet aggregation inhibitor
subclass of: Restriction
  on property: has role
  some values from: P2Y12 receptor antagonist
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
database_cross_reference: CAS:55142-85-3
database_cross_reference: DrugBank:DB00208
database_cross_reference: Drug_Central:2657
database_cross_reference: LINCS:LSM-1986
database_cross_reference: PMID:19180126
database_cross_reference: Reaxys:1216802
has_exact_synonym: 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
has_related_synonym: ticlopidina
has_related_synonym: ticlopidine
has_related_synonym: ticlopidinum
id: CHEBI:9588

ChemIDplus
type: Axiom
annotated source: ticlopidine
annotated property: database_cross_reference
annotated target: CAS:55142-85-3

DrugCentral
type: Axiom
annotated source: ticlopidine
annotated property: database_cross_reference
annotated target: Drug_Central:2657

Europe PMC
type: Axiom
annotated source: ticlopidine
annotated property: database_cross_reference
annotated target: PMID:19180126

Reaxys
type: Axiom
annotated source: ticlopidine
annotated property: database_cross_reference
annotated target: Reaxys:1216802

Trimethadione
type: Class
subclass of: organic molecular entity
database_cross_reference: CAS:127-48-0
database_cross_reference: Drug_Central:2751
database_cross_reference: LINCS:LSM-5345
has_exact_synonym: Trimethadione
has_related_synonym: Tridione (TN)
has_related_synonym: tridione
has_related_synonym: trimetadione
has_related_synonym: trimetin
id: CHEBI:9727

DrugCentral
type: Axiom
annotated source: Trimethadione
annotated property: database_cross_reference
annotated target: CAS:127-48-0

DrugCentral
type: Axiom
annotated source: Trimethadione
annotated property: database_cross_reference
annotated target: Drug_Central:2751

troglitazone
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antioxidant
subclass of: Restriction
  on property: has role
  some values from: hypoglycemic agent
subclass of: Restriction
  on property: has role
  some values from: antineoplastic agent
subclass of: Restriction
  on property: has role
  some values from: vasodilator agent
subclass of: Restriction
  on property: has role
  some values from: anticonvulsant
subclass of: Restriction
  on property: has role
  some values from: anticoagulant
subclass of: Restriction
  on property: has role
  some values from: platelet aggregation inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A chromane that has formula C24H27NO5S.
definition: Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. (by Wikipedia)
formula: C24H27NO5S
description: Wikipedia:Troglitazone
database_cross_reference: ATC:A10BG01
database_cross_reference: Beilstein:4338399
database_cross_reference: CAS:97322-87-7
database_cross_reference: DrugBank:DB00197
database_cross_reference: Drug_Central:2767
database_cross_reference: LINCS:LSM-4890
has_exact_synonym: 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
has_exact_synonym: Troglitazone
has_related_synonym: (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
has_related_synonym: 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
has_related_synonym: Rezulin (TN)
has_related_synonym: Romglizone
has_related_synonym: troglitazona
has_related_synonym: troglitazone
has_related_synonym: troglitazonum
id: CHEBI:9753

Beilstein
type: Axiom
annotated source: troglitazone
annotated property: database_cross_reference
annotated target: Beilstein:4338399

ChemIDplus
type: Axiom
annotated source: troglitazone
annotated property: database_cross_reference
annotated target: CAS:97322-87-7

DrugCentral
type: Axiom
annotated source: troglitazone
annotated property: database_cross_reference
annotated target: Drug_Central:2767

trovafloxacin
type: Class
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: hepatotoxic agent
subclass of: Restriction
  on property: has role
  some values from: topoisomerase IV inhibitor
subclass of: Restriction
  on property: has role
  some values from: DNA synthesis inhibitor
subclass of: Restriction
  on property: has attribute
  some values from: Class
    intersection of: TXPO_0004321
    intersection of: Restriction
      on property: has attribute value
      some values from: TXPO_0004323
definition: A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
database_cross_reference: CAS:147059-72-1
database_cross_reference: DrugBank:DB00685
database_cross_reference: Drug_Central:2777
database_cross_reference: PMID:20022474
database_cross_reference: PMID:20462743
database_cross_reference: PMID:20538741
database_cross_reference: PMID:20655887
database_cross_reference: PMID:21151465
database_cross_reference: PMID:22305082
database_cross_reference: PMID:23727874
database_cross_reference: PMID:24097668
database_cross_reference: PMID:24525298
database_cross_reference: Reaxys:8172628
has_exact_synonym: 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
has_related_synonym: trovafloxacin
has_related_synonym: trovafloxacine
has_related_synonym: trovafloxacino
has_related_synonym: trovafloxacinum
id: CHEBI:9763

ChemIDplus
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: CAS:147059-72-1

DrugCentral
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: Drug_Central:2777

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:20022474

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:20462743

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:20538741

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:20655887

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:21151465

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:22305082

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:23727874

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:24097668

Europe PMC
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: PMID:24525298

Reaxys
type: Axiom
annotated source: trovafloxacin
annotated property: database_cross_reference
annotated target: Reaxys:8172628

ursodeoxycholic acid
type: Class
subclass of: TXPO_0000509
definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
database_cross_reference: InChIKey:RUDATBOHQWOJDD-UZVSRGJWSA-N

cell line cell
type: Class
subclass of: OBI_0001866
definition: A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
imported from: clo.owl

cell
type: Class
subclass of: cellular_component
definition: A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
database_cross_reference: http://purl.bioontology.org/ontology/STY/T025
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).

primary cultured cell
type: Class
subclass of: cultured cell
editor preferred term: primary cultured cell
definition: A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged.
imported from: cl.owl

cultured cell
type: Class
subclass of: experimentally modified cell in vitro
editor preferred term: cultured cell
definition: A cell in vitro that is or has been maintained or propagated as part of a cell culture.
imported from: cl.owl

myoblast
type: Class
subclass of: cell
definition: A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.

fibroblast
type: Class
subclass of: connective tissue cell
definition: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
imported from: cl.owl
database_cross_reference: BTO:0000452
database_cross_reference: FMA:63877

epithelial cell
type: Class
subclass of: cell
editor preferred term: epithelial cell
definition: A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
imported from: cl.owl

T cell
type: Class
subclass of: lymphocyte
editor preferred term: T cell
definition: A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
imported from: cl.owl

Kupffer cell
type: Class
subclass of: tissue-resident macrophage
definition: A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
imported from: cl.owl

granulocyte
type: Class
subclass of: hematopoietic cell
definition: A leukocyte with abundant granules in the cytoplasm.

Axiom
annotated source: granulocyte
annotated property: definition
annotated target: A leukocyte with abundant granules in the cytoplasm.
database_cross_reference: MESH:D006098

mast cell
type: Class
subclass of: leukocyte
definition: A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
imported from: cl.owl
database_cross_reference: BTO:0000830
database_cross_reference: FMA:66784

fat cell
type: Class
subclass of: connective tissue cell
definition: A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
database_cross_reference: BTO:0000443
database_cross_reference: CALOHA:TS-0012
database_cross_reference: FMA:63880
has_exact_synonym: adipocyte
has_exact_synonym: adipose cell

secretory cell
type: Class
subclass of: cell
definition: A cell that specializes in controlled release of one or more substances.
database_cross_reference: BTO:0003659
database_cross_reference: FMA:86916

insulin secreting cell
type: Class
subclass of: secretory cell
definition: insulin secreting cell is a secretory cell and is capable of some insulin secretion
database_cross_reference: BTO:0000783

type B pancreatic cell
type: Class
subclass of: insulin secreting cell
definition: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. A cell that secretes insulin and is located towards the center of the islets of Langerhans.
database_cross_reference: FMA:70586
database_cross_reference: ncithesaurus:Beta_Cell

hepatocyte
type: Class
subclass of: epithelial cell
definition: The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.
imported from: cl.owl

erythrocyte
type: Class
subclass of: hematopoietic cell
editor preferred term: erythrocyte
definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
imported from: cl.owl

platelet
type: Class
subclass of: secretory cell
definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

phagocyte
type: Class
subclass of: cell
definition: Any cell capable of ingesting particulate matter via phagocytosis.

Axiom
annotated source: phagocyte
annotated property: definition
annotated target: Any cell capable of ingesting particulate matter via phagocytosis.
database_cross_reference: ISBN:0721601464

macrophage
type: Class
subclass of: phagocyte
definition: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
imported from: cl.owl
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.

B cell
type: Class
subclass of: lymphocyte
editor preferred term: B cell
definition: A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity.
imported from: cl.owl

white fat cell
type: Class
subclass of: fat cell
definition: Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole.
database_cross_reference: CALOHA:TS-1119
database_cross_reference: FMA:83434

brown fat cell
type: Class
subclass of: fat cell
definition: A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation.
database_cross_reference: CALOHA:TS-0099
database_cross_reference: FMA:83435
has_exact_synonym: brown adipocyte
has_exact_synonym: brown adipose cell

dendritic cell
type: Class
subclass of: leukocyte
editor preferred term: dendritic cell
definition: A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
imported from: cl.owl

lymphocyte
type: Class
subclass of: mononuclear cell
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
imported from: cl.owl

monocyte
type: Class
subclass of: mononuclear cell
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
database_cross_reference: BTO:0000876
database_cross_reference: FMA:62864

experimentally modified cell in vitro
type: Class
subclass of: cell
editor preferred term: experimentally modified cell in vitro
definition: A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.
imported from: cl.owl

hepatic stellate cell
type: Class
subclass of: fibroblast
definition: A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver.
has_exact_synonym: Ito cell
has_exact_synonym: hepatic perisinusoidal cell
has_exact_synonym: perisinusoidal cell

leukocyte
type: Class
subclass of: hematopoietic cell
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
has_exact_synonym: leucocyte
has_exact_synonym: white blood cell

basophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
imported from: cl.owl

Axiom
annotated source: basophil
annotated property: definition
annotated target: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
database_cross_reference: PMCID:PMC2626675
database_cross_reference: PMID:11927641
database_cross_reference: PMID:19741522
database_cross_reference: PMID:9933081

eosinophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.

Axiom
annotated source: eosinophil
annotated property: definition
annotated target: Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
database_cross_reference: ISBN:0721601464
database_cross_reference: PMCID:PMC2626675
database_cross_reference: PMID:10914487
database_cross_reference: PMID:1662676

neutrophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
database_cross_reference: BTO:0000130
database_cross_reference: CALOHA:TS-0688
database_cross_reference: FMA:62860
has_exact_synonym: neutrocyte
has_exact_synonym: neutrophil leucocyte
has_exact_synonym: neutrophil leukocyte
has_exact_synonym: neutrophilic leucocyte
has_exact_synonym: neutrophilic leukocyte

Axiom
annotated source: neutrophil
annotated property: definition
annotated target: Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
comment: ISBN:0721601464

plasma cell
type: Class
subclass of: B cell
editor preferred term: plasma cell
definition: A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
imported from: cl.owl
database_cross_reference: http://purl.jp/bio/10/lsd/term/J089510

alpha-beta T cell
type: Class
subclass of: T cell
editor preferred term: alpha-beta T cell
definition: A T cell that expresses an alpha-beta T cell receptor complex.
imported from: cl.owl

mononuclear cell
type: Class
subclass of: leukocyte
editor preferred term: mononuclear cell
definition: A leukocyte with a single non-segmented nucleus in the mature form.
imported from: cl.owl
database_cross_reference: BTO:0000878
database_cross_reference: CALOHA:TS-0768
database_cross_reference: FMA:86713

inflammatory macrophage
type: Class
subclass of: macrophage
definition: An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.
imported from: cl.owl
has_exact_synonym: M1 macrophage
comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).

tissue-resident macrophage
type: Class
subclass of: macrophage
definition: A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
imported from: cl.owl

foam cell
type: Class
subclass of: cell
definition: A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.

hematopoietic cell
type: Class
subclass of: cell
definition: A cell of a hematopoietic lineage.
database_cross_reference: BTO:0000574
database_cross_reference: CALOHA:TS-2017
database_cross_reference: FMA:70366
database_cross_reference: FMA:83598
has_exact_synonym: haematopoietic cell
has_exact_synonym: haemopoietic cell
has_exact_synonym: hemopoietic cell

connective tissue cell
type: Class
subclass of: cell
definition: A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
database_cross_reference: CALOHA:TS-2096
database_cross_reference: FMA:63875

Niemann-Pick disease type A
type: Class
subclass of: Niemann-Pick disease
definition: A Niemann-Pick disease characterized by onset in infancy and involvement of neurological tissues that has_material_basis_in an autosomal recessive mutation of SMPD1 on chromosome 11p15.4.
database_cross_reference: ICD10CM:E75.2
database_cross_reference: OMIM:257200

Niemann-Pick disease type B
type: Class
subclass of: Niemann-Pick disease
definition: A Niemann-Pick disease characterized by visceral involvement only and survival into adulthood that has_material_basis_in an autosomal recessive mutation of SMPD1 on chromosome 11p15.4.
database_cross_reference: ICD10CM:E75.2
database_cross_reference: OMIM:607616

Niemann-Pick disease type C1
type: Class
subclass of: Niemann-Pick disease
definition: A Niemann-Pick disease that has_material_basis_in an autosomal recessive mutation of NPC1 on chromosome 18q11.2.
database_cross_reference: ICD10CM:E75.2
database_cross_reference: OMIM:257220
has_exact_synonym: NPC1

Niemann-Pick disease type C2
type: Class
subclass of: Niemann-Pick disease
definition: A Niemann-Pick disease that has_material_basis_in an autosomal recessive mutation of NPC2 on chromosome 14q24.3.
database_cross_reference: ICD10CM:E75.2
database_cross_reference: OMIM:607625
has_exact_synonym: NPC2

Niemann-Pick disease
type: Class
subclass of: disease
definition: A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells.
has_exact_synonym: Sphingomyelinase Deficiency Disease
has_exact_synonym: lipoid histiocytosis (classical phosphatide)
has_exact_synonym: sphingomyelin lipidosis

disease
type: Class
subclass of: disposition
definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
database_cross_reference: MESH:D004194
database_cross_reference: NCI:C2991
database_cross_reference: SNOMEDCT_US_2016_03_01:64572001
database_cross_reference: UMLS_CUI:C0012634

diabetes mellitus
type: Class
subclass of: disease
definition: A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
database_cross_reference: MESH:D003920
database_cross_reference: NCI:C298

type 2 diabetes mellitus
type: Class
subclass of: diabetes mellitus
definition: A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.
database_cross_reference: ICD10CM:E11
database_cross_reference: MESH:D003924
database_cross_reference: NCI:C26747
database_cross_reference: SNOMEDCT_US_2018_03_01
has_exact_synonym: NIDDM
has_exact_synonym: non-insulin-dependent diabetes mellitus
has_exact_synonym: type II diabetes mellitus

type 1 diabetes mellitus
type: Class
subclass of: diabetes mellitus
definition: A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.
database_cross_reference: MESH:D003922
database_cross_reference: OMIM:222100
has_exact_synonym: IDDM
has_exact_synonym: insulin-dependent diabetes mellitus
has_exact_synonym: type I diabetes mellitus

substance with antioxidant role
type: Class
equivalent class: Class
  intersection of: chemical entity
  intersection of: Restriction
    on property: has role
    some values from: antioxidant
subclass of: substance with role
subclass of: Restriction
  on property: has role
  some values from: antioxidant
definition: Substance with antioxidant role is a subtype of substance with role. This entity is participating in a oxidative stress response and playing an antioxidant role.

substance with role
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: has role
    some values from: role
subclass of: object
subclass of: Restriction
  on property: has role
  some values from: role
definition: Substance with role is a subtype of object. This entity is participating in a specific process and playing a role.
comment: In YAMATO ontology theory, an entity (continuant) playing a role in a specific context is called a role holder.

substance with ligand role
type: Class
equivalent class: Class
  intersection of: chemical entity
  intersection of: Restriction
    on property: has role
    some values from: TXPO_0000624
subclass of: substance with role
definition: Substance with ligand role is a subtype of substance with role. This entity is participating in signaling and playing a ligand role.
comment: This entity is inferred from Description Logic.

fatty-acyl-CoA binding
type: Class
subclass of: fatty acid derivative binding
subclass of: Restriction
  on property: has input
  some values from: fatty acyl-CoA
definition: Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
has broad synonym: acyl-CoA or acyl binding

Axiom
annotated source: fatty-acyl-CoA binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
database_cross_reference: ISBN:0198506732

cytoplasmic chromosome
type: Class
equivalent class: Class
  intersection of: chromosome
  intersection of: Restriction
    on property: part of
    some values from: cytoplasm
subclass of: chromosome
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A chromosome found in the cytoplasm.
has_narrow_synonym: cytoplasmic interphase chromosome

mitochondrial fission
type: Class
subclass of: TXPO_0002576
subclass of: Restriction
  on property: has input
  some values from: mitochondrion
definition: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
has_exact_synonym: mitochondrial proliferation
has_related_synonym: mitochondrial division

Axiom
annotated source: mitochondrial fission
annotated property: definition
annotated target: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
database_cross_reference: PMID:11038192

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: Wikipedia:M_phase

autophagy of mitochondrion
type: Class
subclass of: autophagy
subclass of: Restriction
  on property: has input
  some values from: mitochondrion
definition: The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
has_exact_synonym: Wikipedia:Mitophagy
has_exact_synonym: mitochondrion autophagy

mitohagy
type: Class
subclass of: autophagy of mitochondrion
subclass of: Restriction
  on property: has input
  some values from: mitochondrion
definition: Degradation of a mitochondrion by macroautophagy.
database_cross_reference: PMID:22406072

pexophagy
type: Class
subclass of: autophagy of peroxisome
subclass of: Restriction
  on property: has input
  some values from: peroxisome
definition: The selective autophagy process in which a peroxisome is degraded by macroautophagy.

Axiom
annotated source: pexophagy
annotated property: definition
annotated target: The selective autophagy process in which a peroxisome is degraded by macroautophagy.
database_cross_reference: PMID:12914914
database_cross_reference: PMID:16973210

response to hypoxia
type: Class
subclass of: response to stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

long-chain fatty acid metabolic process
type: Class
subclass of: fatty acid metabolic process
definition: The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has_exact_synonym: long-chain fatty acid metabolism

formation of cytoplasmic translation initiation complex
type: Class
subclass of: protein complex assembly
definition: Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

cell activation
type: Class
subclass of: TXPO_0000401
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: cell
    intersection of: Restriction
      on property: has quality
      some values from: PATO_0002354
definition: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

natural killer cell proliferation
type: Class
subclass of: lymphocyte proliferation
definition: The expansion of a natural killer cell population by cell division.

cytokine production
type: Class
subclass of: TXPO_0000382
subclass of: Restriction
  on property: has part
  some values from: cytokine biosynthetic process
editor preferred term: cytokine production
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.

release of cytochrome c from mitochondria
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
database_cross_reference: PMID:20850011
database_cross_reference: http://purl.obolibrary.org/obo/HINO_0007325

Axiom
annotated source: release of cytochrome c from mitochondria
annotated property: definition
annotated target: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
database_cross_reference: ISBN:0721639976
database_cross_reference: PMID:12925707
database_cross_reference: PMID:9560217

Axiom
annotated source: release of cytochrome c from mitochondria
annotated property: database_cross_reference
annotated target: PMID:20850011
description: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process.

epithelial to mesenchymal transition
type: Class
subclass of: cell differentiation
definition: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

phagolysosome assembly
type: Class
subclass of: cellular component organization or biogenesis
subclass of: Restriction
  on property: part of
  some values from: phagocytosis
definition: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
has_related_synonym: late phagosome biosynthesis
has_related_synonym: late phagosome formation
has_related_synonym: phagolysosome formation

NK T cell differentiation
type: Class
subclass of: T cell differentiation
definition: The process in which a precursor cell type acquires the specialized features of a NK T cell.
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

TLR signaling pathway
type: Class
subclass of: TXPO_0000609
definition: Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has_exact_synonym: toll-like receptor signaling pathway

natural killer cell mediated immunity
type: Class
subclass of: innate immune response
subclass of: Restriction
  on property: has participant
  some values from: TXPO_0001526
definition: The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
has_exact_synonym: NK cell mediated immunity

adaptive immune response
type: Class
subclass of: immune response
editor preferred term: adaptive immune response
definition: An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
imported from: go.owl

cytokine production involved in immune response
type: Class
subclass of: cytokine production
editor preferred term: cytokine production involved in immune response
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

hepatic immune response
type: Class
subclass of: immune response
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: An immune response taking place in the liver.

immune response to tumor cell
type: Class
subclass of: immune response
definition: An immune system process that functions in the response of an organism to a tumor cell.

leukocyte differentiation
type: Class
subclass of: cell differentiation
definition: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
has_exact_synonym: leucocyte differentiation

cytokine production involved in inflammatory response
type: Class
subclass of: cytokine production
definition: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl
database_cross_reference: GO:0002534

DNA binding
type: Class
subclass of: binding (with molecule)
definition: Process of any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GO:0003677

ketone biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: ketone body
definition: The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
has_exact_synonym: ketone anabolism
has_exact_synonym: ketone biosynthesis
has_exact_synonym: ketone formation
has_exact_synonym: ketone synthesis

binding (with molecule)
type: Class
subclass of: TXPO_0000469
definition: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
curator note: In the definition of GO:0005488 binding is a subtype of Molecular function.

fatty acid binding
type: Class
subclass of: lipid binding
definition: Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
database_cross_reference: GO:0005504

protein binding
type: Class
subclass of: binding (with molecule)
definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
database_cross_reference: GO:0005515
has_exact_synonym: protein amino acid binding

phospholipid binding
type: Class
subclass of: lipid binding
definition: Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
database_cross_reference: GO:0005543

cellular_component
type: Class
subclass of: UBERON_0001062
editor preferred term: cellular component
definition: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
imported from: go.owl

extracellular region
type: Class
subclass of: cell part
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

extracellular space
type: Class
subclass of: cell part
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: NIF_Subcellular:sao1425028079
has_related_synonym: intercellular space
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

Axiom
annotated source: extracellular space
annotated property: definition
annotated target: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: ISBN:0198547684

intracellular
type: Class
subclass of: cell part
definition: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: Wikipedia:Intracellular
has_exact_synonym: internal to cell
has_exact_synonym: protoplasm

Axiom
annotated source: intracellular
annotated property: definition
annotated target: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: ISBN:0198506732

nucleus
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular
subclass of: Restriction
  on property: has part
  some values from: nuclear membrane
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus

chromosome
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
imported from: go.owl
database_cross_reference: Wikipedia:Chromosome
has_related_synonym: chromatid
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:019857684

cytoplasm
type: Class
subclass of: TXPO_0000065
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: Wikipedia:Cytoplasm

Axiom
annotated source: cytoplasm
annotated property: definition
annotated target: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684

mitochondrion
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: has part
  some values from: mitochondrial membrane
editor preferred term: mitochondrion
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
imported from: go.owl
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: ISBN:0198506732

mitochondrial outer membrane
type: Class
subclass of: mitochondrial membrane
definition: The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
database_cross_reference: NIF_Subcellular:sao1289741256
database_cross_reference: Wikipedia:Outer_mitochondrial_membrane

mitochondrial inner membrane
type: Class
subclass of: mitochondrial membrane
definition: The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
database_cross_reference: NIF_Subcellular:sao1371347282
database_cross_reference: Wikipedia:Inner_mitochondrial_membrane
has_exact_synonym: inner mitochondrial membrane

mitochondrial respiratory chain complex I
type: Class
subclass of: inner mitochondrial membrane protein complex
subclass of: Restriction
  on property: has component
  some values from: TXPO_0004329
definition: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

Axiom
annotated source: mitochondrial respiratory chain complex I
annotated property: definition
annotated target: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
database_cross_reference: https://www.worldcat.org/search

mitochondrial respiratory chain complex IV
type: Class
subclass of: inner mitochondrial membrane protein complex
definition: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).

Axiom
annotated source: mitochondrial respiratory chain complex IV
annotated property: definition
annotated target: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
database_cross_reference: https://www.worldcat.org/search

lysosome
type: Class
subclass of: vacuole
subclass of: Restriction
  on property: has part
  some values from: lysosomal membrane
subclass of: Restriction
  on property: has quality
  some values from: PATO_0001429
definition: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: PMID:10751143
database_cross_reference: Wikipedia:Lysosome
comment: Another function of the ER in eucaryotic cells is to sequester Ca2+ from the cytosol. Cell

Axiom
annotated source: lysosome
annotated property: definition
annotated target: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: lysosome
annotated property: database_cross_reference
annotated target: PMID:10751143
description: Lysosome-endosome fusion and lysosome biogenesis. lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a hybrid organelle for digestion of endocytosed macromolecules is created. Lysosomes are then re-formed from hybrid organelles by a process involving condensation of contents.

lysosomal membrane
type: Class
subclass of: organelle membrane
subclass of: Restriction
  on property: part of
  some values from: lysosome
definition: The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

endosome
type: Class
subclass of: vesicle
definition: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: NIF_Subcellular:sao1720343330
database_cross_reference: Wikipedia:Endosome

Axiom
annotated source: endosome
annotated property: definition
annotated target: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:19696797

early endosome
type: Class
subclass of: endosome
definition: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

Axiom
annotated source: early endosome
annotated property: definition
annotated target: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
database_cross_reference: PMID:19696797

late endosome
type: Class
subclass of: endosome
definition: A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

vacuole
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: ISBN:0198506732

autophagosome
type: Class
subclass of: vacuole
definition: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.

Axiom
annotated source: autophagosome
annotated property: definition
annotated target: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
database_cross_reference: PMID:11099404

peroxisome
type: Class
subclass of: microbody
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

Axiom
annotated source: peroxisome
annotated property: definition
annotated target: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
database_cross_reference: PMID:9302272

endoplasmic reticulum
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular
subclass of: Restriction
  on property: has part
  some values from: endoplasmic reticulum lumen
subclass of: Restriction
  on property: has part
  some values from: endoplasmic reticulum membrane
subclass of: Restriction
  on property: agent of
  some values from: lipid biosynthetic process
subclass of: Restriction
  on property: agent of
  some values from: lipid catabolic process
subclass of: Restriction
  on property: agent of
  some values from: sequestering of calcium ion
subclass of: Restriction
  on property: agent of
  some values from: TXPO_0000173
subclass of: Restriction
  on property: agent of
  some values from: TXPO_0000820
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0815332181
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Axiom
annotated source: endoplasmic reticulum
annotated property: database_cross_reference
annotated target: ISBN:0815332181
description: The ER has a central role in lipid and protein biosynthesis. Its membrane is the site of production of all the transmembrane proteins and lipids for most of the cell's organelles, including the ER itself, the Golgi apparatus, lysosomes, endosomes, secretory vesicles, and the plasma membrane. Another function of the ER in eucaryotic cells is to sequester Ca2+ from the cytosol.

endoplasmic reticulum lumen
type: Class
subclass of: organelle lumen
definition: The volume enclosed by the membranes of the endoplasmic reticulum.
has_exact_synonym: ER cisterna
has_exact_synonym: ER lumen
has_exact_synonym: endoplasmic reticulum cisterna

endoplasmic reticulum membrane
type: Class
subclass of: organelle membrane
definition: The lipid bilayer surrounding the endoplasmic reticulum.
has_exact_synonym: ER membrane

smooth endoplasmic reticulum
type: Class
subclass of: endoplasmic reticulum
subclass of: Restriction
  on property: contains process
  some values from: lipoprotein biosynthetic process
subclass of: Restriction
  on property: contains process
  some values from: TXPO_0000173
definition: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
database_cross_reference: ISBN:0815332181
database_cross_reference: NIF_Subcellular:sao710427438
database_cross_reference: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
comment: The hepatocyte is a cell with an abundant smooth ER.

Axiom
annotated source: smooth endoplasmic reticulum
annotated property: definition
annotated target: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: smooth endoplasmic reticulum
annotated property: database_cross_reference
annotated target: ISBN:0815332181
description: It is usually prominent in cells that specialize in lipid metabolism. Cells that synthesize steroid hormones from cholesterol, for example, have an expanded smooth ER compartment to accommodate the enzymes needed to make cholesterol and to modify it to form the hormones. It is the principal site of production of lipoprotein particles, which carry lipids via the bloodstream to other parts of the body. The enzymes that synthesize the lipid components of lipoproteins are located in the membrane of the smooth ER, which also contains enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and various harmful compounds produced by metabolism.

rough endoplasmic reticulum
type: Class
subclass of: endoplasmic reticulum
definition: The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
database_cross_reference: NIF_Subcellular:sao1881364067;
database_cross_reference: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
has_exact_synonym: RER
has_exact_synonym: rough ER

Axiom
annotated source: rough endoplasmic reticulum
annotated property: definition
annotated target: The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
database_cross_reference: ISBN:0198506732

golgi apparatus
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: Golgi lumen
definition: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: golgi apparatus
annotated property: definition
annotated target: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
database_cross_reference: ISBN:0198506732

Golgi lumen
type: Class
subclass of: organelle lumen
definition: The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

microtubule organizing center
type: Class
subclass of: cell part
subclass of: Restriction
  on property: part of
  some values from: cytoskeleton
definition: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: Wikipedia:Microtubule_organizing_center
has_exact_synonym: MOC
has_exact_synonym: microtubule organising centre

Axiom
annotated source: microtubule organizing center
annotated property: definition
annotated target: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:17072892
database_cross_reference: PMID:17245416

cytosol
type: Class
subclass of: TXPO_0000065
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol

ribosome
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: NIF_Subcellular:sao1429207766
database_cross_reference: Wikipedia:Ribosome
has_narrow_synonym: free ribosome
has_narrow_synonym: membrane bound ribosome
has_related_synonym: ribosomal RNA

Axiom
annotated source: ribosome
annotated property: definition
annotated target: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: free ribosome
database_cross_reference: NIF_Subcellular:sao1139385046

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: membrane bound ribosome
comment: NIF_Subcellular:sao1291545653

cytoskeleton
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16959967

plasma membrane
type: Class
subclass of: TXPO_0000895
subclass of: Restriction
  on property: part of
  some values from: cell
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins
database_cross_reference: ISBN:0716731363

carbohydrate metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: has part
  some values from: carbohydrate biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: carbohydrate catabolic process
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
database_cross_reference: Wikipedia:Carbohydrate_metabolism

glycogen metabolic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: Restriction
  on property: has part
  some values from: glycogen biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: glycogen catabolic process
definition: The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.

glycogen biosynthetic process
type: Class
subclass of: carbohydrate biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: glycogen
definition: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
database_cross_reference: Reactome:REACT_1736
has_exact_synonym: glycogen anabolism
has_exact_synonym: glycogen biosynthesis
has_exact_synonym: glycogen formation
has_exact_synonym: glycogen synthesis

Axiom
annotated source: glycogen biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: glycogen biosynthetic process
annotated property: database_cross_reference
annotated target: Reactome:REACT_1736
description: Glycogen synthesis, Homo sapiens

glycogen catabolic process
type: Class
subclass of: carbohydrate catabolic process
subclass of: Restriction
  on property: has input
  some values from: glycogen
definition: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
database_cross_reference: Reactome:REACT_1008
has_exact_synonym: glycogen breakdown
has_exact_synonym: glycogen catabolism
has_exact_synonym: glycogen degradation
has_exact_synonym: glycogenolysis

Axiom
annotated source: glycogen catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: glycogen catabolic process
annotated property: database_cross_reference
annotated target: Reactome:REACT_1008
description: Glycogen breakdown (glycogenolysis), Homo sapiens

alcohol metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
has_exact_synonym: alcohol metabolism

Axiom
annotated source: alcohol metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
database_cross_reference: CHEBI:30879
database_cross_reference: ISBN:0198506732

generation of precursor metabolites and energy
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.

gluconeogenesis
type: Class
subclass of: carbohydrate biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: glucose
definition: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
database_cross_reference: Reactome:R-HSA-70263
has_exact_synonym: glucose biosynthesis
has_exact_synonym: glucose biosynthetic process

Axiom
annotated source: gluconeogenesis
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-70263
description: Gluconeogenesis, Homo sapiens

glycolytic process
type: Class
subclass of: carbohydrate catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

tricarboxylic acid cycle
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria.
database_cross_reference: Reactome: R-HSA-71403.2
has_exact_synonym: Krebs cycle
has_exact_synonym: TCA cycle
has_exact_synonym: Wikipedia:Tricarboxylic_acid_cycle
has_exact_synonym: citric acid cycle

regulation of carbohydrate metabolic process
type: Class
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: carbohydrate metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
has_exact_synonym: regulation of carbohydrate metabolism

oxidative phosphorylation
type: Class
subclass of: phosphorylation
definition: The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
has_exact_synonym: respiratory-chain phosphorylation

Axiom
annotated source: oxidative phosphorylation
annotated property: definition
annotated target: The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0471331309

mitochondrial electron transport, NADH to ubiquinone
type: Class
subclass of: respiratory electron transport chain
definition: The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
has_exact_synonym: oxidative phosphorylation, NADH to ubiquinone
has_related_synonym: complex I (NADH to ubiquinone)

Axiom
annotated source: mitochondrial electron transport, NADH to ubiquinone
annotated property: definition
annotated target: The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
database_cross_reference: ISBN:0716731363

mitochondrial electron transport, succinate to ubiquinone
type: Class
subclass of: respiratory electron transport chain
definition: The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.
has_exact_synonym: mitochondrial electron transport, succinate to coenzyme Q
has_related_synonym: complex II (succinate to ubiquinone)
has_related_synonym: oxidative phosphorylation, succinate to ubiquinone

Axiom
annotated source: mitochondrial electron transport, succinate to ubiquinone
annotated property: definition
annotated target: The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.
database_cross_reference: ISBN:0716731363

mitochondrial electron transport, ubiquinol to cytochrome c
type: Class
subclass of: respiratory electron transport chain
definition: The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
has_related_synonym: complex III (ubiquinone to cytochrome c)

Axiom
annotated source: mitochondrial electron transport, ubiquinol to cytochrome c
annotated property: definition
annotated target: The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
database_cross_reference: ISBN:0716731363

DNA replication
type: Class
subclass of: TXPO_0000093
subclass of: Restriction
  on property: manifests phenotype
  some values from: TXPO_0000304
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

DNA repair
type: Class
subclass of: TXPO_0000535
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Axiom
annotated source: DNA repair
annotated property: definition
annotated target: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: PMID:11563486

DNA alkylation
type: Class
subclass of: metabolic process
definition: The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.

DNA methylation
type: Class
subclass of: methylation
definition: The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

DNA catabolic process
type: Class
subclass of: catabolic process
definition: The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

apoptotic DNA fragmentation
type: Class
subclass of: DNA catabolic process
definition: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
database_cross_reference: PMID:15723341
has_exact_synonym: Apoptosis induced DNA fragmentation
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).

chromatin remodeling
type: Class
subclass of: TXPO_0002566
definition: Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

transcription, DNA-templated
type: Class
subclass of: gene expression
definition: The cellular synthesis of RNA on a template of DNA.
database_cross_reference: GO:0006351
database_cross_reference: http://purl.obolibrary.org/obo/IEV_0000183
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: cellular transcription, DNA-dependent

regulation of transcription, DNA-templated
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: transcription, DNA-templated
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
has_exact_synonym: regulation of cellular transcription, DNA-dependent

mRNA cleavage
type: Class
subclass of: TXPO_0000333
definition: Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.

mRNA catabolic process
type: Class
subclass of: catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

translation
type: Class
subclass of: gene expression
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: Wikipedia:Translation_(genetics)

regulation of translation
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: translation
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
has_exact_synonym: regulation of protein anabolism
has_exact_synonym: regulation of protein biosynthesis
has_exact_synonym: regulation of protein formation
has_exact_synonym: regulation of protein synthesis

protein folding
type: Class
subclass of: TXPO_0002565
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: PMID:15459659
database_cross_reference: PMID:15519848
database_cross_reference: Reactome:R-HSA-391251
database_cross_reference: Wikipedia:Protein_folding
comment: Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).

Axiom
annotated source: protein folding
annotated property: comment
annotated target: Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).
database_cross_reference: R-HSA-391251

protein complex assembly
type: Class
subclass of: protein-containing complex assembly
definition: The aggregation, arrangement and bonding together of a set of components to form a protein complex.
has_exact_synonym: protein complex formation

protein acetylation
type: Class
subclass of: protein acylation
definition: The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

protein deacetylation
type: Class
subclass of: protein deacylation
definition: The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

protein glycosylation
type: Class
subclass of: glycosylation
definition: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

protein lipidation
type: Class
subclass of: protein modification process
definition: The covalent attachment of lipid groups to an amino acid in a protein.
has_exact_synonym: lipid:protein modification

proteolysis
type: Class
subclass of: TXPO_0000333
subclass of: Restriction
  on property: has input
  some values from: protein
definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
database_cross_reference: Wikipedia:Proteolysis
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

protein deglycosylation
type: Class
subclass of: protein modification process
definition: The removal of sugar residues from a glycosylated protein.

cellular amino acid metabolic process
type: Class
subclass of: small molecule metabolic process
subclass of: Restriction
  on property: occurs in
  some values from: cell
subclass of: Restriction
  on property: has participant
  some values from: amino acid
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
has_exact_synonym: amino acid and derivative metabolism
has_exact_synonym: amino acid metabolic process
has_exact_synonym: cellular amino acid and derivative metabolic process
has_exact_synonym: cellular amino acid metabolism

methionine metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: has part
  some values from: TXPO_0001165
definition: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
has_exact_synonym: methionine metabolism

S-adenosylmethionine biosynthetic process
type: Class
subclass of: biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

lipid metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: has part
  some values from: lipid biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: lipid catabolic process
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
has_exact_synonym: lipid metabolism

fatty acid metabolic process
type: Class
subclass of: lipid metabolic process
subclass of: Restriction
  on property: has part
  some values from: fatty acid biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: fatty acid catabolic process
definition: The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
database_cross_reference: Wikipedia:Fatty_acid_metabolism
has_exact_synonym: fatty acid metabolism

Axiom
annotated source: fatty acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
database_cross_reference: ISBN:0198547684

fatty acid biosynthetic process
type: Class
subclass of: lipid biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
database_cross_reference: MetaCyc:PWY-4381
database_cross_reference: Wikipedia:Fatty_acid_synthesis
has_exact_synonym: fatty acid anabolism
has_exact_synonym: fatty acid biosynthesis
has_exact_synonym: fatty acid formation
has_exact_synonym: fatty acid synthesis

fatty acid beta-oxidation
type: Class
subclass of: fatty acid oxidation
definition: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

Axiom
annotated source: fatty acid beta-oxidation
annotated property: definition
annotated target: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
database_cross_reference: ISBN:0198506732

phospholipid metabolic process
type: Class
subclass of: lipid metabolic process
subclass of: Restriction
  on property: has part
  some values from: phospholipid biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: phospholipid catabolic process
definition: The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
has_exact_synonym: phospholipid metabolism
has OBO namespace: biological_process

Axiom
annotated source: phospholipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
database_cross_reference: ISBN:0198506732

phosphatidylethanolamine biosynthetic process
type: Class
subclass of: glycerophospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidylethanolamine
definition: The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
has_exact_synonym: phosphatidylethanolamine anabolism
has_exact_synonym: phosphatidylethanolamine biosynthesis
has_exact_synonym: phosphatidylethanolamine formation
has_exact_synonym: phosphatidylethanolamine synthesis
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylethanolamine biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
database_cross_reference: ISBN:0198506732

phospholipid transfer to membrane
type: Class
subclass of: phospholipid transport
subclass of: Restriction
  on property: has target end location
  some values from: TXPO_0000895
definition: The transfer of a phospholipid from its site of synthesis to the plasma membrane.

glycerophospholipid metabolic process
type: Class
subclass of: phospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: glycerophospholipid
definition: The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
has_exact_synonym: glycerophospholipid metabolism
has_exact_synonym: phosphoglyceride metabolic process
has_exact_synonym: phosphoglyceride metabolism
has_related_synonym: alpha-glycerophosphate pathway

Axiom
annotated source: glycerophospholipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
database_cross_reference: ISBN:0198506732

phosphatidic acid biosynthetic process
type: Class
subclass of: phosphatidic acid metabolic process
subclass of: glycerophospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidic acid
definition: The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
has_exact_synonym: phosphatidic acid anabolism
has_exact_synonym: phosphatidic acid biosynthesis
has_exact_synonym: phosphatidic acid formation
has_exact_synonym: phosphatidic acid synthesis

Axiom
annotated source: phosphatidic acid biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
database_cross_reference: ISBN:0198506732

phosphatidylglycerol biosynthetic process
type: Class
subclass of: phosphatidylglycerol metabolic process
subclass of: glycerophospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidylglycerol
definition: The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
has_exact_synonym: phosphatidylglycerol anabolism
has_exact_synonym: phosphatidylglycerol biosynthesis
has_exact_synonym: phosphatidylglycerol formation
has_exact_synonym: phosphatidylglycerol synthesis

Axiom
annotated source: phosphatidylglycerol biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
database_cross_reference: ISBN:0198506732

phosphatidylcholine biosynthetic process
type: Class
subclass of: phosphatidylcholine metabolic process
subclass of: glycerophospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidylcholine
definition: The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
has_exact_synonym: phosphatidylcholine anabolism
has_exact_synonym: phosphatidylcholine biosynthesis
has_exact_synonym: phosphatidylcholine formation
has_exact_synonym: phosphatidylcholine synthesis

Axiom
annotated source: phosphatidylcholine biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
database_cross_reference: ISBN:0198506732

phosphatidylserine metabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: phosphatidyl-L-serine
definition: The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
has_exact_synonym: phosphatidylserine metabolism
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylserine metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
database_cross_reference: ISBN:0198506732

phosphatidylserine biosynthetic process
type: Class
subclass of: phosphatidylserine metabolic process
subclass of: glycerophospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidyl-L-serine
definition: The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
has_exact_synonym: phosphatidylserine anabolism
has_exact_synonym: phosphatidylserine biosyntheis
has_exact_synonym: phosphatidylserine biosynthesis
has_exact_synonym: phosphatidylserine formation
has_exact_synonym: phosphatidylserine synthesis
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylserine biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: phosphatidylserine biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
comment: ISBN:0198506732

phosphatidylserine catabolic process
type: Class
subclass of: phosphatidylserine metabolic process
subclass of: glycerophospholipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: phosphatidyl-L-serine
definition: The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
has_exact_synonym: phosphatidylserine breakdown
has_exact_synonym: phosphatidylserine catabolism
has_exact_synonym: phosphatidylserine degradation
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylserine catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
database_cross_reference: ISBN:0198506732

phosphatidylinositol biosynthetic process
type: Class
subclass of: glycerophospholipid biosynthetic process
subclass of: phosphatidylinositol metabolic process
subclass of: Restriction
  on property: has output
  some values from: phosphatidylinositol
definition: The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
description: Phosphatidylinositol (PI) is synthesized when phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG) followed by conversion into PI and cytidine monophosphate (CMP) (Stuhne-Sekalec et al 1986, Lykidis et al. 1997).
database_cross_reference: http://purl.obolibrary.org/obo/HINO_0013926
has_exact_synonym: PtdIns biosynthesis
has_exact_synonym: PtdIns biosynthetic process
has_exact_synonym: phosphatidylinositol anabolism
has_exact_synonym: phosphatidylinositol biosynthesis
has_exact_synonym: phosphatidylinositol formation
has_exact_synonym: phosphatidylinositol synthesis
has_exact_synonym: phosphoinositide biosynthesis
has_exact_synonym: phosphoinositide biosynthetic process

Axiom
annotated source: phosphatidylinositol biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
database_cross_reference: CHEBI:28874
database_cross_reference: ISBN:0198506732

sphingolipid metabolic process
type: Class
subclass of: lipid metabolic process
definition: The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
has_exact_synonym: sphingolipid metabolism

sphingomyelin metabolic process
type: Class
subclass of: phospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: sphingomyelin
definition: The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
has_exact_synonym: sphingomyelin metabolism
has OBO namespace: biological_process

Axiom
annotated source: sphingomyelin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
database_cross_reference: ISBN:0198506732

sphingomyelin catabolic process
type: Class
subclass of: sphingomyelin metabolic process
subclass of: TXPO_0001465
subclass of: Restriction
  on property: has input
  some values from: sphingomyelin
definition: The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
has_exact_synonym: sphingomyelin breakdown
has_exact_synonym: sphingomyelin catabolism
has_exact_synonym: sphingomyelin degradation
has OBO namespace: biological_process

Axiom
annotated source: sphingomyelin catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
database_cross_reference: ISBN:0198506732

sphingomyelin biosynthetic process
type: Class
subclass of: sphingomyelin metabolic process
subclass of: TXPO_0001291
subclass of: Restriction
  on property: has output
  some values from: sphingomyelin
definition: The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
has_exact_synonym: sphingomyelin anabolism
has_exact_synonym: sphingomyelin biosynthesis
has_exact_synonym: sphingomyelin formation
has_exact_synonym: sphingomyelin synthesis

Axiom
annotated source: sphingomyelin biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
database_cross_reference: ISBN:0198506732

cholesterol biosynthetic process
type: Class
subclass of: lipid biosynthetic process
definition: The chemical reaction resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
database_cross_reference: GO:0006695

bile acid biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: TXPO_0000509
definition: The chemical reactions resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

estrogen catabolic process
type: Class
subclass of: estrogen metabolic process
subclass of: catabolic process
subclass of: Restriction
  on property: has input
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: has role
      some values from: estrogen
definition: The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants
has_exact_synonym: estrogen breakdown
has_exact_synonym: estrogen catabolism
has_exact_synonym: estrogen degradation

NADH regeneration
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has participant
  some values from: NAD(+)
subclass of: Restriction
  on property: has output
  some values from: NADH
definition: A metabolic process that generates a pool of NADH by the reduction of NAD+.
has_exact_synonym: NAD (reduced) regeneration
has_exact_synonym: reduced NAD regeneration
has_exact_synonym: reduced nicotinamide adenine dinucleotide regeneration

NADPH regeneration
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: NADPH
definition: A metabolic process that generates a pool of NADPH by the reduction of NADP+.
database_cross_reference: Reactome:R-HSA-389542
database_cross_reference: https://reactome.org/PathwayBrowser/#/R-HSA-389542
has_exact_synonym: NADP (reduced) regeneration
has_exact_synonym: reduced NADP regeneration
has_exact_synonym: reduced nicotinamide adenine dinucleotide phosphate regeneration

glutathione metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle
database_cross_reference: CHEBI:16856
database_cross_reference: ISBN:0198506732
has_exact_synonym: glutathione metabolism

glutathione biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: L-gamma-glutamyl-L-cysteinylglycine
subclass of: Restriction
  on property: has pathway
  some values from: Glutathione synthesis and recycling
subclass of: Restriction
  on property: has pathway
  some values from: TXPO_0000652
definition: The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
database_cross_reference: GO:0006750
database_cross_reference: https://reactome.org/PathwayBrowser/#/R-HSA-174403
has_exact_synonym: glutathione anabolism
has_exact_synonym: glutathione biosynthesis
has_exact_synonym: glutathione formation
has_exact_synonym: glutathione synthesis

ATP biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: oxidative phosphorylation
subclass of: Restriction
  on property: has part
  some values from: ATP synthesis coupled electron transport
subclass of: Restriction
  on property: has output
  some values from: ATP
definition: The chemical reaction resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
database_cross_reference: GO:0006754
has_exact_synonym: ATP anabolism
has_exact_synonym: ATP biosynthesis
has_exact_synonym: ATP formation
has_exact_synonym: ATP synthesis
has_narrow_synonym: ATP regeneration

heme biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: iron atom
definition: The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
has_exact_synonym: heme anabolism
has_exact_synonym: heme biosynthesis
has_exact_synonym: heme formation
has_exact_synonym: heme synthesis

phosphorus metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
database_cross_reference: phosphorus metabolic process

xenobiotic metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e. g. a xenobiotic chemical, such as a pesticide. (Gene Ontology)
database_cross_reference: ISBN:0071769234
has_exact_synonym: xenobiotic biotransformation
comment: Xenobiotic biotransformation is metabolic conversion of xenobiotic chemicals to more hydrophilic (water-soluble) compounds.

Axiom
annotated source: xenobiotic metabolic process
annotated property: database_cross_reference
annotated target: ISBN:0071769234
description: Biotransfomation to harmful products is called toxication/metabolic activation [casarett and doull's toxicology 8th ed.]

transport
type: Class
subclass of: TXPO_0000442
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.

ion transport
type: Class
subclass of: transport
subclass of: TXPO_0000111
definition: The directed movement of charged atoms or small charged molecules into, out of, within or between cells.

potassium ion transport
type: Class
subclass of: ion transport
definition: The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

neurotransmitter transport
type: Class
subclass of: transport
definition: The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

lipid transport
type: Class
subclass of: TXPO_0000111
definition: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

Axiom
annotated source: lipid transport
annotated property: definition
annotated target: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: ISBN:0198506732

endocytosis
type: Class
subclass of: TXPO_0002587
definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
database_cross_reference: Wikipedia:Endocytosis

Axiom
annotated source: endocytosis
annotated property: definition
annotated target: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0716731363

phagocytosis
type: Class
subclass of: TXPO_0002587
subclass of: Restriction
  on property: has part
  some values from: phagolysosome assembly
subclass of: Restriction
  on property: has part
  some values from: phagocytosis, recognition
definition: A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
database_cross_reference: Wikipedia:Phagocytosis

Axiom
annotated source: phagocytosis
annotated property: definition
annotated target: A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
database_cross_reference: ISBN:0198506732

phagocytosis, recognition
type: Class
subclass of: TXPO_0000379
subclass of: Restriction
  on property: part of
  some values from: phagocytosis
definition: The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.
has_exact_synonym: recognition of phagocytosed substance by phagocytic cell
comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'.

nucleocytoplasmic transport
type: Class
subclass of: nuclear transport
definition: The directed movement of molecules between the nucleus and the cytoplasm.

autophagy
type: Class
subclass of: catabolic process
definition: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation
database_cross_reference: Wikipedia:Autophagy_(cellular)

Axiom
annotated source: autophagy
annotated property: definition
annotated target: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:11099404
database_cross_reference: PMID:9412464

apoptotic process
type: Class
subclass of: cell death
subclass of: Restriction
  on property: has agent
  some values from: cell
definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
database_cross_reference: IEV:0000070 (obsolete)
database_cross_reference: Wikipedia:Apoptosis
has_exact_synonym: apoptotic cell death
has_exact_synonym: apoptotic programmed cell death
has_exact_synonym: programmed cell death by apoptosis

cell motility
type: Class
subclass of: locomotion
subclass of: Restriction
  on property: has participant
  some values from: cell
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
has_exact_synonym: cell locomotion
has_exact_synonym: cell movement
has_exact_synonym: movement of a cell

response to stress
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

immune response
type: Class
subclass of: response to stimulus
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000296
subclass of: Restriction
  on property: has part
  some values from: TXPO_0003646
subclass of: Restriction
  on property: has part
  some values from: TXPO_0003990
definition: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

cellular response to DNA damage stimulus
type: Class
subclass of: response to stimulus
editor preferred term: cellular response to DNA damage stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

response to oxidative stress
type: Class
subclass of: response to stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Axiom
annotated source: response to oxidative stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
database_cross_reference: PMID:121115731

organelle organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton.
has_exact_synonym: organelle organisation

mitochondrion organization
type: Class
subclass of: TXPO_0000468
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

cytoskeleton organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation

actin filament organization
type: Class
subclass of: actin cytoskeleton organization and biogenesis
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.

cytoplasm organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
has_exact_synonym: cytoplasm organisation

vacuole organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.

lysosomal transport
type: Class
subclass of: transport
definition: The directed movement of substances into, out of or within a lysosome.

cell cycle
type: Class
subclass of: TXPO_0000425
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

cell cycle arrest
type: Class
subclass of: TXPO_0003798
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle
definition: A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
has_exact_synonym: arrest of cell cycle progression
has_exact_synonym: cessation of cell cycle
has_exact_synonym: termination of cell cycle

cell adhesion
type: Class
subclass of: TXPO_0002581
subclass of: Restriction
  on property: occurs in
  some values from: cell
subclass of: Restriction
  on property: has participant
  some values from: cell
definition: The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.
has_exact_synonym: Wikipedia:Cell_adhesion

epidermal growth factor receptor signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: EGF receptor signaling pathway
has_exact_synonym: EGFR signaling pathway

transforming growth factor beta receptor signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: TGF-beta receptor signaling pathway

Notch signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

I-kappaB kinase/NF-kappaB signaling
type: Class
subclass of: TXPO_0000027
subclass of: Restriction
  on property: has part
  some values from: TXPO_0002779
subclass of: Restriction
  on property: has part
  some values from: TXPO_0002781
subclass of: Restriction
  on property: has part
  some values from: TXPO_0002783
subclass of: Restriction
  on property: has part
  some values from: TXPO_0002785
subclass of: Restriction
  on property: has part
  some values from: TXPO_0002789
definition: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. PMID:12773372
has_exact_synonym: I-kappaB kinase-NF-kappaB signal transduction pathway

cytoplasmic sequestering of NF-kappaB
type: Class
subclass of: TXPO_0000433
definition: The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.

feeding behavior
type: Class
subclass of: TXPO_0002587
definition: Behavior associated with the intake of food.
database_cross_reference: Wikipedia:List_of_feeding_behaviours

metabolic process
type: Class
subclass of: TXPO_0000261
definition: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
database_cross_reference: Wikipedia:Metabolism
has_exact_synonym: metabolism
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

Axiom
annotated source: metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
database_cross_reference: ISBN:0198547684

estrogen metabolic process
type: Class
subclass of: hormone metabolic process
definition: The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.

cell death
type: Class
subclass of: TXPO_0000437
subclass of: Restriction
  on property: has input
  some values from: cell
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).

cell proliferation
type: Class
subclass of: TXPO_0000093
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000062
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: cell
    intersection of: Restriction
      on property: has quality
      some values from: PATO_0002002
subclass of: Restriction
  on property: has agent
  some values from: cell
definition: The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.

insulin receptor signaling pathway
type: Class
subclass of: TXPO_0000027
definition: The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
database_cross_reference: https://reactome.org/PathwayBrowser/#/R-HSA-74752
has_exact_synonym: insulin receptor signalling pathway

lipid binding
type: Class
subclass of: binding (with molecule)
definition: Interacting selectively and non-covalently with a lipid.

RNA splicing
type: Class
subclass of: TXPO_0000333
definition: The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

phosphatidylethanolamine binding
type: Class
subclass of: phospholipid binding
definition: Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
database_cross_reference: GO:0008429
database_cross_reference: Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

Axiom
annotated source: phosphatidylethanolamine binding
annotated property: database_cross_reference
annotated target: Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
database_cross_reference: ISBN:0198506732

lipid biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: lipid
definition: The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
has_exact_synonym: lipid anabolism
has_exact_synonym: lipid biosynthesis
has_exact_synonym: lipid formation
has_exact_synonym: lipogenesis

extrinsic apoptotic signaling pathway via death domain receptors
type: Class
subclass of: TXPO_0000611
definition: A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
database_cross_reference: PMID:21525013
database_cross_reference: https://reactome.org/PathwayBrowser/#/R-HSA-140534&PATH=R-HSA-5357801,R-HSA-109581,R-HSA-5357769

Axiom
annotated source: extrinsic apoptotic signaling pathway via death domain receptors
annotated property: database_cross_reference
annotated target: PMID:21525013
description: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84)

carbohydrate transport
type: Class
subclass of: TXPO_0000111
definition: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GO:0008643
has_narrow_synonym: sugar transport

phospholipid biosynthetic process
type: Class
subclass of: lipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: phospholipid
definition: The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
has_exact_synonym: phospholipid anabolism
has_exact_synonym: phospholipid biosynthesis
has_exact_synonym: phospholipid formation
has_exact_synonym: phospholipid synthesis

Axiom
annotated source: phospholipid biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
database_cross_reference: ISBN:0198506732

catabolic process
type: Class
subclass of: TXPO_0000185
definition: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: Wikipedia:Catabolism

Axiom
annotated source: catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: ISBN:0198547684

biosynthetic process
type: Class
subclass of: TXPO_0000019
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000387
definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
has_exact_synonym: anabolism
has_exact_synonym: biosynthesis
has_exact_synonym: synthesis

fatty acid catabolic process
type: Class
subclass of: lipid catabolic process
subclass of: Restriction
  on property: has part
  some values from: fatty acid oxidation
subclass of: Restriction
  on property: has input
  some values from: TXPO_0000834
definition: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
database_cross_reference: Wikipedia:Fatty_acid_degradation
has_exact_synonym: fatty acid catabolism
has_exact_synonym: fatty acid degradation

cobalamin biosynthetic process
type: Class
subclass of: biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
has_exact_synonym: vitamin B12 biosynthesis

glycolipid biosynthetic process
type: Class
subclass of: lipid biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
has_exact_synonym: glycolipid anabolism
has_exact_synonym: glycolipid biosynthesis

attenuation of translation
type: Class
subclass of: regulation of translation
subclass of: Restriction
  on property: negatively regulates
  some values from: translation
definition: Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. the system requires the presence of a short orf, called a leader peptide, encoded in the mrna upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. the stalled ribosome masks a region of the mrna and affects which of two alternative mrna folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mrna remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.

Axiom
annotated source: attenuation of translation
annotated property: definition
annotated target: Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. the system requires the presence of a short orf, called a leader peptide, encoded in the mrna upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. the stalled ribosome masks a region of the mrna and affects which of two alternative mrna folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mrna remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.
database_cross_reference: PMID:15694341
database_cross_reference: PMID:15805513

phospholipid catabolic process
type: Class
subclass of: lipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: phospholipid
definition: The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
has_exact_synonym: phospholipid breakdown
has_exact_synonym: phospholipid catabolism
has_exact_synonym: phospholipid degradation

toxin metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
has_exact_synonym: toxin metabolism

response to external stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
has_exact_synonym: response to environmental stimulus
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

response to endogenous stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

membrane invagination
type: Class
subclass of: TXPO_0002587
definition: The infolding of a membrane.

gene expression
type: Class
subclass of: TXPO_0002282
subclass of: Restriction
  on property: has result
  some values from: TXPO_0000382
definition: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Gene_expression
comment: A changing process to convert a gene's sequenes into a mature gene prduct(s), i.e., (m)RNA, or protein.

regulation of gene expression
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: has part
  some values from: positive regulation of gene expression
subclass of: Restriction
  on property: has part
  some values from: negative regulation of gene expression
subclass of: Restriction
  on property: regulates
  some values from: gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_narrow_synonym: regulation of protein expression
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.

proteasomal protein catabolic process
type: Class
subclass of: protein catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
has_exact_synonym: proteasome-mediated protein catabolic process
has_exact_synonym: proteasome-mediated protein catabolism

regulation of autophagy
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: autophagy
definition: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

negative regulation of autophagy
type: Class
subclass of: regulation of autophagy
subclass of: Restriction
  on property: negatively regulates
  some values from: autophagy
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

positive regulation of autophagy
type: Class
subclass of: regulation of autophagy
subclass of: Restriction
  on property: positively regulates
  some values from: autophagy
definition: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

positive regulation of gene expression
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: gene expression
definition: Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

negative regulation of gene expression
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: has part
  some values from: attenuation of translation
subclass of: Restriction
  on property: has part
  some values from: negative regulation of transcription, DNA-templated
subclass of: Restriction
  on property: negatively regulates
  some values from: gene expression
definition: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.

negative regulation of extracellular matrix disassembly
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: extracellular matrix disassembly
definition: Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.

macrophage derived foam cell differentiation
type: Class
subclass of: foam cell differentiation
definition: The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

regulation of macrophage derived foam cell differentiation
type: Class
subclass of: regulation of cell differentiation
definition: Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

positive regulation of macrophage derived foam cell differentiation
type: Class
subclass of: regulation of macrophage derived foam cell differentiation
subclass of: Restriction
  on property: dysfunctioning of
  some values from: macrophage derived foam cell differentiation
definition: Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

negative regulation of macrophage derived foam cell differentiation
type: Class
subclass of: regulation of macrophage derived foam cell differentiation
definition: Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

cholesterol storage
type: Class
subclass of: lipid storage
subclass of: Restriction
  on property: has input
  some values from: cholesterol
definition: The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
database_cross_reference: GO:0010878
has_narrow_synonym: cholesterol sequestration
has_narrow_synonym: sequestration of cholesterol

negative regulation of lipid storage
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: lipid storage
definition: Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

negative regulation of phosphatidylcholine catabolic process
type: Class
subclass of: TXPO_0001304
definition: Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

regulation of cell death
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: cell death
definition: Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. [

bile acid and bile salt transport
type: Class
subclass of: transport
definition: The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_narrow_synonym: bile acid transport

Axiom
annotated source: bile acid and bile salt transport
annotated property: definition
annotated target: The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: PMID:12663868
database_cross_reference: PMID:14699511

canalicular bile acid transport
type: Class
subclass of: bile acid and bile salt transport
definition: Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

choline transport
type: Class
subclass of: TXPO_0000111
definition: The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.

drug transport
type: Class
subclass of: transport
definition: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

fatty acid transport
type: Class
subclass of: lipid transport
definition: The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis

long-chain fatty acid transport
type: Class
subclass of: fatty acid transport
definition: The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

long-chain fatty acid import into peroxisome
type: Class
subclass of: long-chain fatty acid transport
definition: The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

phospholipid transport
type: Class
subclass of: lipid transport
definition: The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

electron transport coupled proton transport
type: Class
subclass of: proton transmembrane transport
definition: The transport of protons against an electrochemical gradient, using energy from electron transport.

lipid catabolic process
type: Class
subclass of: catabolic process
subclass of: Restriction
  on property: has input
  some values from: lipid
definition: The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: Wikipedia:Lipid_catabolism
has_exact_synonym: lipid breakdown
has_exact_synonym: lipid catabolism
has_exact_synonym: lipid degradation
has_exact_synonym: lipolysis

cell growth
type: Class
subclass of: growth
definition: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has_exact_synonym: cellular growth
has_exact_synonym: growth of cell

carbohydrate biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: carbohydrate
definition: The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
has_exact_synonym: anabolic carbohydrate metabolic process
has_exact_synonym: anabolic carbohydrate metabolism
has_exact_synonym: carbohydrate anabolism
has_exact_synonym: carbohydrate biosynthesis
has_exact_synonym: carbohydrate formation
has_exact_synonym: carbohydrate synthesis

carbohydrate catabolic process
type: Class
subclass of: catabolic process
subclass of: Restriction
  on property: has input
  some values from: carbohydrate
definition: The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
has_exact_synonym: carbohydrate biosynthesis
has_exact_synonym: carbohydrate catabolism
has_exact_synonym: carbohydrate degradation
has_exact_synonym: catabolic carbohydrate metabolic process
has_exact_synonym: catabolic carbohydrate metabolism

Axiom
annotated source: carbohydrate catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: ISBN:0198506732

vesicle-mediated transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: occurs in
  some values from: cell
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
has_exact_synonym: vesicle transport
has_exact_synonym: vesicular transport
has_related_synonym: vesicle trafficking

endosomal transport
type: Class
subclass of: vesicle-mediated transport
definition: The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.

gap junction assembly
type: Class
subclass of: cell junction assembly
definition: Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.
database_cross_reference: Reactome:REACT_9509

phosphorylation
type: Class
subclass of: phosphorus metabolic process
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: EC:2.7.-.-
database_cross_reference: Wikipedia:Phosphorylation

dephosphorylation
type: Class
subclass of: phosphorus metabolic process
definition: The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.

cell migration
type: Class
subclass of: TXPO_0000003
definition: The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
database_cross_reference: Wikipedia:Cell_migration

protein processing
type: Class
subclass of: proteolysis
definition: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
has_exact_synonym: protein maturation by peptide bond cleavage

protein deubiquitination
type: Class
subclass of: protein modification by small protein removal
definition: The removal of one or more ubiquitin groups from a protein.

protein sumoylation
type: Class
subclass of: TXPO_0004107
definition: The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
database_cross_reference: Wikipedia:SUMO_protein
has_exact_synonym: SUMO-protein conjugation
has_exact_synonym: protein sumolation
has_exact_synonym: sumoylation

triglyceride binding
type: Class
subclass of: lipid binding
definition: Interacting selectively and non-covalently with any triester of glycerol.
description: Interacting selectively and non-covalently with any triester of glycerol.
database_cross_reference: GO:0017129

drug metabolic process
type: Class
subclass of: xenobiotic metabolic process
definition: The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
database_cross_reference: Wikipedia:Drug_metabolism
has_exact_synonym: drug metabolism

protein myristoylation
type: Class
subclass of: protein lipidation
definition: The covalent attachment of a myristoyl group to a protein.

protein glucuronidation
type: Class
subclass of: protein modification process
definition: The modification of a protein by amino acid glucuronidation.
has_related_synonym: glucronide conjugation

regulation of lipid metabolic process
type: Class
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: lipid metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
has_exact_synonym: regulation of lipid metabolism

regulation of metabolic process
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
has_exact_synonym: regulation of metabolism

fatty acid oxidation
type: Class
subclass of: lipid oxidation
definition: The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

Axiom
annotated source: fatty acid oxidation
annotated property: definition
annotated target: The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
database_cross_reference: ISBN:0198506732

protein metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: has part
  some values from: protein catabolic process
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000306
subclass of: Restriction
  on property: has participant
  some values from: protein
definition: The chemical reactions and pathways involving a protein. Includes protein modification.
database_cross_reference: Wikipedia:Protein_metabolism
has_exact_synonym: protein metabolism

glucuronate metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.

cytolysis
type: Class
subclass of: TXPO_0000437
subclass of: Restriction
  on property: occurs in
  some values from: cell
definition: The rupture of cell membranes and the loss of cytoplasm.
database_cross_reference: Wikipedia:Cytolysis

lipid storage
type: Class
subclass of: TXPO_0000247
subclass of: Restriction
  on property: has input
  some values from: lipid
definition: The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
has_exact_synonym: lipid retention
has_exact_synonym: lipid sequestering
has_exact_synonym: retention of lipids
has_exact_synonym: sequestration of lipid
has_exact_synonym: sequestration of lipids
has_exact_synonym: storage of lipids

cell cycle phase
type: Class
subclass of: PATO_0000083
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.

extracellular matrix disassembly
type: Class
subclass of: TXPO_0000343
subclass of: Restriction
  on property: has input
  some values from: extracellular matrix
definition: A process that results in the breakdown of the extracellular matrix.

cellular component assembly
type: Class
subclass of: TXPO_0000468
subclass of: Restriction
  on property: occurs in
  some values from: cell
definition: The aggregation, arrangement and bonding together of a cellular component.
has_exact_synonym: cellular component assembly at cellular level

electron transport chain
type: Class
subclass of: transport
subclass of: oxidation-reduction process
definition: A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
database_cross_reference: Wikipedia:Electron_transport_chain

respiratory electron transport chain
type: Class
subclass of: electron transport chain
definition: A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
database_cross_reference: Wikipedia:Electron_transfer
has_exact_synonym: electron transfer

Axiom
annotated source: respiratory electron transport chain
annotated property: definition
annotated target: A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
database_cross_reference: ISBN:0716720094

regulation of signaling
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: TXPO_0000471
definition: Any process that modulates the frequency, rate or extent of a signaling process.

signaling [biological] (primitive)
type: Class
subclass of: TXPO_0000471
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000020
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
has_exact_synonym: biological signaling (primitive)
has_exact_synonym: signalling (primitive)
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

negative regulation of signaling
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: signaling [biological] (primitive)
subclass of: Restriction
  on property: negatively regulates
  some values from: TXPO_0000609
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.

lamellipodium biogenesis
type: Class
subclass of: cellular component organization or biogenesis
definition: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

actin cytoskeleton organization and biogenesis
type: Class
subclass of: cytoskeleton organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

insulin secretion
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: insulin
definition: The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.

Axiom
annotated source: insulin secretion
annotated property: definition
annotated target: The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
database_cross_reference: ISBN:0198506732

protein repair
type: Class
subclass of: TXPO_0000535
definition: The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.

lymphocyte differentiation
type: Class
subclass of: leukocyte differentiation
definition: The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
has_exact_synonym: lymphocyte cell differentiation
has_exact_synonym: lymphocytic blood cell differentiation
has_related_synonym: lymphocyte development
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

natural killer cell activation
type: Class
subclass of: lymphocyte activation
definition: The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
database_cross_reference: http://purl.obolibrary.org/obo/IEV_0003880
has_exact_synonym: NK cell activation

cell differentiation
type: Class
subclass of: TXPO_0002282
subclass of: Restriction
  on property: occurs in
  some values from: cell
subclass of: Restriction
  on property: has agent
  some values from: cell
definition: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: Wikipedia:Cellular_differentiation

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

protein catabolic process
type: Class
subclass of: catabolic process
subclass of: Restriction
  on property: has input
  some values from: protein
definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
database_cross_reference: Wikipedia:Protein_catabolism
has_exact_synonym: protein breakdown
has_exact_synonym: protein catabolism
has_exact_synonym: protein degradation
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.

extracellular matrix organization
type: Class
subclass of: TXPO_0000468
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.

T cell differentiation
type: Class
subclass of: lymphocyte differentiation
definition: The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
has_exact_synonym: T lymphocyte differentiation
has_exact_synonym: T-cell differentiation
has_exact_synonym: T-lymphocyte differentiation

macrophage differentiation
type: Class
subclass of: leukocyte differentiation
definition: The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
has_exact_synonym: macrophage cell differentiation

Axiom
annotated source: macrophage differentiation
annotated property: definition
annotated target: The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
database_cross_reference: ISBN:0781735149

autophagy of peroxisome
type: Class
subclass of: autophagy
subclass of: Restriction
  on property: has input
  some values from: peroxisome
definition: The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.
database_cross_reference: PMID:10547367
database_cross_reference: PMID:20083110

cholesterol transport
type: Class
subclass of: lipid transport
definition: The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Axiom
annotated source: cholesterol transport
annotated property: definition
annotated target: The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: ISBN:0198506732

negative regulation of transforming growth factor beta receptor signaling pathway
type: Class
subclass of: negative regulation of signaling
subclass of: Restriction
  on property: negatively regulates
  some values from: transforming growth factor beta receptor signaling pathway
subclass of: Restriction
  on property: negatively regulates
  some values from: TXPO_0001854
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

leukocyte chemotaxis
type: Class
subclass of: leukocyte migration
definition: The movement of a leukocyte in response to an external stimulus.
has_exact_synonym: immune cell chemotaxis
has_exact_synonym: leucocyte chemotaxis

sequestering of triglyceride
type: Class
subclass of: lipid storage
subclass of: Restriction
  on property: has input
  some values from: triglyceride
definition: The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
database_cross_reference: GO:0030730
has_exact_synonym: retention of triacylglycerol
has_exact_synonym: retention of triglyceride
has_exact_synonym: sequestering of triacylglycerol
has_exact_synonym: triacylglycerol sequestering
has_exact_synonym: triacylglycerol sequestration
has_exact_synonym: triacylglycerol storage
has_exact_synonym: triglyceride storage

epithelial cell differentiation
type: Class
subclass of: cell differentiation
definition: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

Axiom
annotated source: epithelial cell differentiation
annotated property: definition
annotated target: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
database_cross_reference: PMID:11839751

protein splicing
type: Class
subclass of: protein processing
definition: The post-translational removal of peptide sequences from within a protein sequence.

endoplasmic reticulum unfolded protein response
type: Class
subclass of: response to endoplasmic reticulum stress
definition: The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
has_exact_synonym: ER unfolded protein response
comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.

Axiom
annotated source: endoplasmic reticulum unfolded protein response
annotated property: definition
annotated target: The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
database_cross_reference: PMID:12042763

retrograde protein transport, ER to cytosol
type: Class
subclass of: TXPO_0000111
subclass of: Restriction
  on property: has target start location
  some values from: endoplasmic reticulum
subclass of: Restriction
  on property: has target end location
  some values from: cytosol
definition: The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
database_cross_reference: PMID:11994744
has_exact_synonym: protein retrotranslocation, ER to cytosol
has_exact_synonym: retrograde protein transport, endoplasmic reticulum to cytosol

Axiom
annotated source: retrograde protein transport, ER to cytosol
annotated property: definition
annotated target: The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
definition source: PMID:11994744

extracellular matrix
type: Class
subclass of: TXPO_0000065
definition: A structure lying external to one or more cells, which provides structural support for cells or tissues.
database_cross_reference: MESH:D005109
database_cross_reference: NCIT:C13232

organelle membrane
type: Class
subclass of: TXPO_0000895
definition: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
has_related_synonym: intracellular membrane

stress-activated protein kinase signaling cascade
type: Class
subclass of: TXPO_0000609
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000769
definition: A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
database_cross_reference: PMID:11790549
has_exact_synonym: JNK signal transduction pathway

Axiom
annotated source: stress-activated protein kinase signaling cascade
annotated property: database_cross_reference
annotated target: PMID:11790549
description: An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

phosphatidylinositol catabolic process
type: Class
subclass of: glycerophospholipid catabolic process
subclass of: phosphatidylinositol metabolic process
subclass of: Restriction
  on property: has input
  some values from: phosphatidylinositol
definition: The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
has_exact_synonym: PtdIns catabolic process
has_exact_synonym: PtdIns catabolism
has_exact_synonym: phosphatidylinositol breakdown
has_exact_synonym: phosphatidylinositol catabolism
has_exact_synonym: phosphatidylinositol degradation

Axiom
annotated source: phosphatidylinositol catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
database_cross_reference: GOC:mah

phosphatidylcholine binding
type: Class
subclass of: phospholipid binding
definition: Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
database_cross_reference: GO:0031210

negative regulation of protein complex assembly
type: Class
subclass of: TXPO_0004212
subclass of: Restriction
  on property: negatively regulates
  some values from: protein complex assembly
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
has_exact_synonym: down regulation of protein complex assembly
has_exact_synonym: down-regulation of protein complex assembly
has_exact_synonym: downregulation of protein complex assembly
has_narrow_synonym: inhibition of protein complex assembly
has_narrow_synonym: negative regulation of protein complex assembly

actin cytoskeleton reorganization
type: Class
subclass of: actin cytoskeleton organization and biogenesis
definition: A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
has_exact_synonym: actin cytoskeleton remodeling

heat generation
type: Class
subclass of: TXPO_0000381
definition: Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.

TOR signaling
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
has_exact_synonym: TOR signaling cascade
has_exact_synonym: TOR signaling pathway
has_exact_synonym: target of rapamycin signaling pathway

nuclear membrane
type: Class
subclass of: organelle membrane
definition: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
database_cross_reference: NIF_Subcellular:sao1687101204

mitochondrial membrane
type: Class
subclass of: organelle membrane
subclass of: Restriction
  on property: has quality
  some values from: PATO_0000970
definition: Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
database_cross_reference: NIF_Subcellular:sao1045389829

vesicle
type: Class
subclass of: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: Any small, fluid-filled, spherical organelle enclosed by membrane.
has_related_synonym: membrane-bounded vesicle
has_related_synonym: membrane-enclosed vesicle

mitochondrial DNA catabolic process
type: Class
subclass of: DNA catabolic process
subclass of: Restriction
  on property: has input
  all values from: EFO_0008480
definition: The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.

cardiolipin biosynthetic process
type: Class
subclass of: phosphatidylglycerol biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: cardiolipin
definition: The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
database_cross_reference: MetaCyc:PWY-5269
has_related_synonym: diphosphatidylglycerol biosynthesis
has_related_synonym: diphosphatidylglycerol biosynthetic process

Axiom
annotated source: cardiolipin biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
database_cross_reference: CHEBI:28494
database_cross_reference: GOC:mah

bleb assembly
type: Class
subclass of: cellular component organization or biogenesis
definition: The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
has broad synonym: membrane blebbing
database_cross_reference: PMID:12083798
database_cross_reference: PMID:16624291
database_cross_reference: http://en.wikipedia.org/wiki/Bleb_(cell_biology)
has_exact_synonym: cell blebbing
has_exact_synonym: plasma membrane bleb assembly

methylation
type: Class
subclass of: metabolic process
definition: The process in which a methyl group is covalently attached to a molecule.

endocytic recycling
type: Class
subclass of: endosomal transport
definition: The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
has_related_synonym: retrograde transport of endocytic vesicles

Axiom
annotated source: endocytic recycling
annotated property: definition
annotated target: The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
comment: PMID:16473635

chemokine production
type: Class
subclass of: cytokine production
editor preferred term: chemokine production
definition: The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

type I interferon production
type: Class
subclass of: cytokine production
editor preferred term: type I interferon production
definition: The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
imported from: go.owl

interferon-gamma production
type: Class
subclass of: cytokine production
editor preferred term: interferon-gamma production
definition: The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
imported from: go.owl

IL-1 beta production
type: Class
subclass of: cytokine production
subclass of: Restriction
  on property: has agent
  some values from: Kupffer cell
definition: The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

interleukin-1 production
type: Class
subclass of: cytokine production
editor preferred term: interleukin-1 production
definition: The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl
database_cross_reference: GO:0032612

interleukin-2 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

tumor necrosis factor production
type: Class
subclass of: tumor necrosis factor superfamily cytokine production
editor preferred term: tumor necrosis factor production
definition: The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
alternative term: TNF alpha production
imported from: go.owl

bile acid secretion
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: TXPO_0000509
definition: The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
description: Bile contains bile acids, glutathione, phospholipids, cholesterol, bilirubin, and other organic anions, proteins, metals, ions, and xenobiotics. Hepatocytes begins the formation of bile by transporting bile acids, glutathione, and other solutes including Xenobiotics and their metabolites into the canalicular lumen. The major driving force of bile formation is the active transport of bile salts and other osmolytes into the canalicular lumen. Most conjugated bile acids (taurine and glycine conjugates) and some unconjugated bile acids are transported into hepatocytes by sodium-dependent transporters. Sodium-independent uptake of conjugated and unconjugated bile acids is performed by members of the organic anion-transporting polypeptides (OATPs). OATPs also transport numerous drugs and hepatotoxicants. Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids. Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2).

transforming growth factor beta1 production
type: Class
subclass of: cytokine production
editor preferred term: transforming growth factor beta1 production
definition: The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

mitochondrial respiratory chain complex I assembly
type: Class
subclass of: mitochondrial respiratory chain complex assembly
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
has_exact_synonym: mitochondrial NADH dehydrogenase complex (ubiquinone) assembly
has_exact_synonym: mitochondrial complex I assembly

mitochondrial respiratory chain complex assembly
type: Class
subclass of: protein-containing complex assembly
subclass of: Restriction
  on property: part of
  some values from: mitochondrion organization
definition: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.

tumor necrosis factor-mediated signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

cholesterol efflux
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: cholesterol
definition: The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
has_exact_synonym: cholesterol export

mitochondrial respiratory chain complex IV assembly
type: Class
subclass of: mitochondrial respiratory chain complex assembly
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.
has_exact_synonym: mitochondrial cytochrome c oxidase biogenesis
has_exact_synonym: mitochondrial cytochrome c oxidase complex assembly

phospholipid efflux
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: phospholipid
definition: The directed movement of a phospholipid out of a cell or organelle.

TLR4 signaling pathway
type: Class
subclass of: TLR signaling pathway
definition: Any series of molecular signals generated as a consequence of binding to toll-like receptor 4.
has_exact_synonym: toll-like receptor 4 signaling pathway

TLR9 signaling pathway
type: Class
subclass of: TLR signaling pathway
definition: Any series of molecular signals generated as a consequence of binding to toll-like receptor 9.
has_exact_synonym: toll-like receptor 9 signaling pathway

triglyceride transport
type: Class
subclass of: lipid transport
definition: The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
has_exact_synonym: triacylglycerol transport

cell junction assembly
type: Class
subclass of: TXPO_0000468
definition: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.

adherens junction assembly
type: Class
subclass of: cellular component assembly
definition: The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

very-low-density lipoprotein particle assembly
type: Class
subclass of: protein-lipid complex assembly
subclass of: Restriction
  on property: has output
  some values from: very-low-density lipoprotein
definition: The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.

lipid droplet organization
type: Class
subclass of: TXPO_0000468
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.

lipid oxidation
type: Class
subclass of: oxidation-reduction process
definition: The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

phosphatidylglycerol catabolic process
type: Class
subclass of: phosphatidylglycerol metabolic process
subclass of: glycerophospholipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: phosphatidylglycerol
definition: The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
has_exact_synonym: phosphatidylglycerol breakdown
has_exact_synonym: phosphatidylglycerol catabolism
has_exact_synonym: phosphatidylglycerol degradation

Axiom
annotated source: phosphatidylglycerol catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
database_cross_reference: GOC:mah

mitochondrial respiratory chain complex III assembly
type: Class
subclass of: mitochondrial respiratory chain complex assembly
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.
has_exact_synonym: mitochondrial cytochrome bc(1) complex assembly

mitochondrial respiratory chain complex II assembly
type: Class
subclass of: mitochondrial respiratory chain complex assembly
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.

glutathione transport
type: Class
subclass of: transport
definition: The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

phosphatidylcholine catabolic process
type: Class
subclass of: phosphatidylcholine metabolic process
subclass of: glycerophospholipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: phosphatidylcholine
definition: The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
has_exact_synonym: phosphatidylcholine breakdown
has_exact_synonym: phosphatidylcholine catabolism
has_exact_synonym: phosphatidylcholine degradation

Axiom
annotated source: phosphatidylcholine catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
database_cross_reference: GOC:jp

response to endoplasmic reticulum stress
type: Class
subclass of: response to stress
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
has_exact_synonym: ER stress response
has_exact_synonym: cellular response to endoplasmic reticulum stress
has_exact_synonym: response to ER stress

gene silencing by miRNA
type: Class
subclass of: regulation of gene expression
definition: Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.

Axiom
annotated source: gene silencing by miRNA
annotated property: definition
annotated target: Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
database_cross_reference: PMID:14744438
database_cross_reference: PMID:15066275
database_cross_reference: PMID:23209154

helper T cell enhancement of adaptive immune response
type: Class
subclass of: adaptive immune response
definition: Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.

protein deacylation
type: Class
subclass of: protein modification process
definition: The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.

hepatic stellate cell activation
type: Class
subclass of: cell activation
subclass of: Restriction
  on property: has input
  some values from: hepatic stellate cell
definition: A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.

positive regulation of mitochondrial membrane permeability
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrial membrane
subclass of: Restriction
  on property: positively regulates
  some values from: TXPO_0000799
definition: Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

long-chain fatty acid binding
type: Class
subclass of: fatty acid binding
definition: Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

long-chain fatty acyl-CoA binding
type: Class
subclass of: fatty-acyl-CoA binding
subclass of: Restriction
  on property: has input
  some values from: long-chain fatty acyl-CoA
definition: Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

protein modification process
type: Class
subclass of: protein metabolic process
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Fas signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.

IRE1-mediated unfolded protein response
type: Class
subclass of: TXPO_0002155
definition: A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
has_exact_synonym: UPR signaling by IRE1 stress sensor
has_exact_synonym: endoplasmic reticulum unfolded protein response; IRE1 signaling

Axiom
annotated source: IRE1-mediated unfolded protein response
annotated property: definition
annotated target: A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
database_cross_reference: PMID:22013210

PERK-mediated unfolded protein response
type: Class
subclass of: TXPO_0000285
definition: A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
has_exact_synonym: UPR signaling by PERK stress sensor
has_exact_synonym: endoplasmic reticulum unfolded protein response; PERK signaling

Axiom
annotated source: PERK-mediated unfolded protein response
annotated property: definition
annotated target: A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
database_cross_reference: PMID:22013210

ATF6-mediated unfolded protein response
type: Class
subclass of: TXPO_0002126
definition: A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
has_exact_synonym: activating transcription factor 6 signaling in unfolded protein response
has_exact_synonym: endoplasmic reticulum unfolded protein response; ATF6 signaling

Axiom
annotated source: ATF6-mediated unfolded protein response
annotated property: definition
annotated target: A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
database_cross_reference: PMID:22013210

ERAD pathway
type: Class
subclass of: proteasomal protein catabolic process
definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
has_exact_synonym: endoplasmic reticulum-associated degradation
has_exact_synonym: protein degradation by ERAD
comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.

Axiom
annotated source: ERAD pathway
annotated property: definition
annotated target: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
database_cross_reference: PMID:20940304
database_cross_reference: PMID:21969857

interleukin-2-mediated signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: IL-2-mediated signaling pathway

CCL2 signal transduction pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals mediated by CCL2 (C-C chemokine CCL2). A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: CCL2-activated CCR2 signaling pathway

growth
type: Class
subclass of: TXPO_0000138
definition: The increase in size or mass of an entire organism, a part of an organism or a cell.

locomotion
type: Class
subclass of: TXPO_0000765
definition: Self-propelled movement of a cell or organism from one location to another.

regulation of gene expression, epigenetic
type: Class
subclass of: regulation of gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.

Axiom
annotated source: regulation of gene expression, epigenetic
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
database_cross_reference: PMID:10521337

protein refolding
type: Class
subclass of: protein folding
definition: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
database_cross_reference: PMID:23637286

negative regulation of epidermal growth factor receptor signaling pathway
type: Class
subclass of: negative regulation of signaling
subclass of: Restriction
  on property: negatively regulates
  some values from: epidermal growth factor receptor signaling pathway
subclass of: Restriction
  on property: negatively regulates
  some values from: TXPO_0001492
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
has_exact_synonym: down regulation of epidermal growth factor receptor signaling pathway
has_exact_synonym: negative regulation of EGF receptor signaling pathway
has_exact_synonym: negative regulation of EGF receptor signalling pathway
has_exact_synonym: negative regulation of EGFR signaling pathway
has_exact_synonym: negative regulation of epidermal growth factor receptor signaling pathway

cytokine biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: has role
      some values from: TXPO_0000622
definition: The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
has_exact_synonym: cytokine anabolism
has_exact_synonym: cytokine biosynthesis
has_exact_synonym: cytokine formation

Axiom
annotated source: cytokine biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0198599471

T cell proliferation
type: Class
subclass of: lymphocyte proliferation
definition: The expansion of a T cell population by cell division. Follows T cell activation.
has_exact_synonym: T lymphocyte proliferation
has_exact_synonym: T-cell proliferation
has_exact_synonym: T-lymphocyte proliferation

Axiom
annotated source: T cell proliferation
annotated property: definition
annotated target: The expansion of a T cell population by cell division. Follows T cell activation.
database_cross_reference: GO:0042098

B cell proliferation
type: Class
subclass of: lymphocyte proliferation
definition: The expansion of a B cell population by cell division. Follows B cell activation.
has_exact_synonym: B lymphocyte proliferation
has_exact_synonym: B-cell proliferation
has_exact_synonym: B-lymphocyte proliferation

Axiom
annotated source: B cell proliferation
annotated property: definition
annotated target: The expansion of a B cell population by cell division. Follows B cell activation.
database_cross_reference: GO:0042100

T cell activation
type: Class
subclass of: lymphocyte activation
definition: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

macrophage activation
type: Class
subclass of: leukocyte activation
definition: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
has_exact_synonym: macrophage polarization

lipoprotein biosynthetic process
type: Class
subclass of: TXPO_0000306
definition: The chemical reaction resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
has_exact_synonym: lipoprotein anabolism
has_exact_synonym: lipoprotein biosynthesis

negative regulation of protein catabolic process
type: Class
subclass of: TXPO_0000115
subclass of: Restriction
  on property: negatively regulates
  some values from: protein catabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

RNA repair
type: Class
subclass of: TXPO_0000535
definition: Any process that results in the repair of damaged RNA.

tissue regeneration
type: Class
subclass of: TXPO_0002590
definition: Tissue regeneration is a subtype of changing material: The regrowth of lost or destroyed tissues.

hormone metabolic process
type: Class
subclass of: metabolic process
has_exact_synonym: The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
has_exact_synonym: hormone metabolism

Axiom
annotated source: hormone metabolic process
annotated property: has_exact_synonym
annotated target: The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
database_cross_reference: CHEBI:24621

microbody
type: Class
subclass of: membrane-bounded organelle
definition: Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

homeostatic process
type: Class
subclass of: TXPO_0000682
definition: Any biological process involved in the maintenance of an internal steady state.

ATP synthesis coupled electron transport
type: Class
subclass of: respiratory electron transport chain
definition: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

mitochondrial ATP synthesis coupled electron transport
type: Class
subclass of: ATP synthesis coupled electron transport
subclass of: Restriction
  on property: observed in
  some values from: mitochondrion
definition: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

Axiom
annotated source: mitochondrial ATP synthesis coupled electron transport
annotated property: definition
annotated target: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
database_cross_reference: ISBN:0716731363

regulation of apoptotic process
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: apoptotic process
definition: Any process that modulates the occurrence or rate of cell death by apoptotic process.
database_cross_reference: Reactome:R-HSA-169911

Axiom
annotated source: regulation of apoptotic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169911
database_cross_reference: http://www.reactome.org/content/detail/REACT_13648

positive regulation of apoptotic process
type: Class
subclass of: regulation of apoptotic process
subclass of: Restriction
  on property: positively regulates
  some values from: apoptotic process
definition: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
has_exact_synonym: positive regulation of apoptotic process
has_exact_synonym: up regulation of apoptosis
has_exact_synonym: up-regulation of apoptosis
has_exact_synonym: upregulation of apoptosis
has_narrow_synonym: activation of apoptosis
has_related_synonym: pro-apoptosis

negative regulation of apoptotic process
type: Class
subclass of: regulation of apoptotic process
subclass of: Restriction
  on property: negatively regulates
  some values from: apoptotic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
database_cross_reference: GO:0043066
has_exact_synonym: anti-apoptosis
has_exact_synonym: down regulation of apoptosis
has_exact_synonym: down-regulation of apoptosis
has_exact_synonym: downregulation of apoptosis
has_narrow_synonym: inhibition of apoptosis
has_narrow_synonym: negative regulation of apoptosis
has_related_synonym: pro-survival

proteasome-mediated ubiquitin-dependent protein catabolic process
type: Class
subclass of: proteasomal protein catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

organelle
type: Class
subclass of: cellular_component
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao1539965131
database_cross_reference: Wikipedia:Organelle

membrane-bounded organelle
type: Class
subclass of: organelle
editor preferred term: membrane-bounded organelle
definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
imported from: go.owl

organelle lumen
type: Class
subclass of: UBERON_0000464
definition: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

regulation of potassium ion transport
type: Class
subclass of: regulation of transport (biology)
subclass of: Restriction
  on property: regulates
  some values from: potassium ion transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

negative regulation of potassium ion transport
type: Class
subclass of: regulation of potassium ion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

positive regulation of potassium ion transport
type: Class
subclass of: regulation of potassium ion transport
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

anoikis
type: Class
subclass of: apoptotic process
definition: Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
database_cross_reference: An adherent cell-restricted lethal cascade that is ignited by detachment from the matrix and that is characterized by (i) lack of beta1-integrin engagement, (ii) downregulation of EGFR expression, (iii) inhibition of extracellular-regulated kinase 1 (ERK1) signaling, and (iv) overexpression of the BCL-2 family member BIM. It should be noted that in most, if not all, instances, the cell death program ignited by anoikis is executed by the molecular machinery for intrinsic apoptosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252826/
database_cross_reference: Wikipedia:Anoikis

apoptotic cell clearance
type: Class
subclass of: TXPO_0000458
definition: The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
has_exact_synonym: apoptotic cell removal

Axiom
annotated source: apoptotic cell clearance
annotated property: definition
annotated target: The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
database_cross_reference: PMID:14685684

protein unfolding
type: Class
subclass of: TXPO_0002565
definition: The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
curator note: chaperone-mediated protein transport involved in chaperone-mediated autophagy subClassOf : has_part some protein unfolding

regulation of generation of precursor metabolites and energy
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: generation of precursor metabolites and energy
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.

accumulation of pigments
type: Class
subclass of: TXPO_0000247
subclass of: Restriction
  on property: has input
  some values from: pigment granule
definition: The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus.

protein kinase B signaling
type: Class
subclass of: TXPO_0000609
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. PMID:20517722
database_cross_reference: GO:004349
has_exact_synonym: AKT signaling

protein acylation
type: Class
subclass of: protein modification process
definition: The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.

small molecule metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: occurs in
  some values from: cell
definition: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
comment: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.

cell part
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cell
definition: Any constituent part of a cell, the basic structural and functional unit of all organisms.
has_exact_synonym: cellular subcomponent

dendritic cell proliferation
type: Class
subclass of: lymphocyte proliferation
definition: The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.

cell cycle phase transition
type: Class
subclass of: TXPO_0000425
definition: The cell cycle process by which a cell commits to entering the next cell cycle phase.
has_exact_synonym: cell cycle transition

cell quiescence
type: Class
subclass of: cell cycle phase
definition: A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.

cell cycle G2/M phase transition
type: Class
subclass of: cell cycle phase transition
definition: The cell cycle process by which a cell in G2 phase commits to M phase.

cell cycle G1/S phase transition
type: Class
subclass of: cell cycle phase transition
definition: The cell cycle process by which a cell in G1 phase commits to S phase.

innate immune response
type: Class
subclass of: immune response
definition: Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

regulation of innate immune response
type: Class
subclass of: regulation of immune response
subclass of: Restriction
  on property: regulates
  some values from: innate immune response
definition: Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

protein palmitoleylation
type: Class
subclass of: protein lipidation
definition: The covalent attachment of a palmitoleyl group to a protein.

leukocyte activation
type: Class
subclass of: cell activation
definition: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
has_exact_synonym: immune cell activation
has_exact_synonym: leucocyte activation

Adipocyte differentiation
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: has participant
  some values from: fat cell
definition: The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
has_exact_synonym: adipocyte cell differentiation
has_exact_synonym: adipose cell differentiation
has_exact_synonym: fat cell differentiation

myoblast differentiation
type: Class
subclass of: TXPO_0002703
definition: The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
has_exact_synonym: myoblast cell differentiation

endothelial cell differentiation
type: Class
subclass of: epithelial cell differentiation
definition: The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

regulation of cell differentiation
type: Class
subclass of: TXPO_0000113
definition: Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.

negative regulation of gluconeogenesis
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: gluconeogenesis
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
has_exact_synonym: down regulation of gluconeogenesis
has_exact_synonym: down-regulation of gluconeogenesis
has_exact_synonym: downregulation of gluconeogenesis

negative regulation of DNA repair
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: DNA repair
definition: Negative regulation of DNA repair is a subtype of negative regulation process: A process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.

positive regulation of cell cycle
type: Class
subclass of: regulation of cell cycle
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: cell cycle
definition: Any process that activates or increases the rate or extent of progression through the cell cycle.
has_exact_synonym: positive regulation of cell cycle progression
has_exact_synonym: positive regulation of progression through cell cycle

negative regulation of endocytosis
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: endocytosis
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.

negative regulation of glycolytic process
type: Class
subclass of: TXPO_0000115
subclass of: Restriction
  on property: negatively regulates
  some values from: glycolytic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
has_exact_synonym: down regulation of glycolysis
has_exact_synonym: down-regulation of glycolysis
has_exact_synonym: downregulation of glycolysis

positive regulation of proteolysis
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: proteolysis
definition: Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

negative regulation of transcription, DNA-templated
type: Class
subclass of: regulation of transcription, DNA-templated
subclass of: Restriction
  on property: negatively regulates
  some values from: transcription, DNA-templated
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
has_exact_synonym: down regulation of transcription, DNA-dependent
has_exact_synonym: down-regulation of transcription, DNA-dependent

ATP metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: has part
  some values from: ATP biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: TXPO_0001165
definition: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.

aflatoxin metabolic process
type: Class
subclass of: toxin metabolic process
definition: The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
has_exact_synonym: aflatoxin metabolism

phosphatidylethanolamine catabolic process
type: Class
subclass of: glycerophospholipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: phosphatidylethanolamine
definition: The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
has_exact_synonym: phosphatidylethanolamine breakdown
has_exact_synonym: phosphatidylethanolamine catabolism
has_exact_synonym: phosphatidylethanolamine degradation
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylethanolamine catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
database_cross_reference: ISBN:0198506732

phosphatidylcholine metabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: phosphatidylcholine
definition: The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
has_exact_synonym: phosphatidylcholine metabolism
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylcholine metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
database_cross_reference: ISBN:0198506732

phosphatidylglycerol metabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: phosphatidylglycerol
definition: The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.
has_exact_synonym: phosphatidylglycerol metabolism
has OBO namespace: biological_process

Axiom
annotated source: phosphatidylglycerol metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.
database_cross_reference: ISBN:0198506732

phosphatidic acid metabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: phosphatidic acid
definition: The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
has_exact_synonym: phosphatidic acid metabolism
has OBO namespace: biological_process

Axiom
annotated source: phosphatidic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
database_cross_reference: ISBN:0198506732

glycerophospholipid biosynthetic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: phospholipid biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: glycerophospholipid
definition: The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
has_exact_synonym: glycerophospholipid anabolism
has_exact_synonym: glycerophospholipid biosynthesis
has_exact_synonym: glycerophospholipid formation
has_exact_synonym: glycerophospholipid synthesis
has_exact_synonym: phosphoglyceride biosynthesis
has_exact_synonym: phosphoglyceride biosynthetic process
has OBO namespace: biological_process

Axiom
annotated source: glycerophospholipid biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
database_cross_reference: ISBN:0198506732

glycerophospholipid catabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: phospholipid catabolic process
subclass of: Restriction
  on property: has input
  some values from: glycerophospholipid
definition: The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
has_exact_synonym: glycerophospholipid breakdown
has_exact_synonym: glycerophospholipid catabolism
has_exact_synonym: glycerophospholipid degradation
has_exact_synonym: phosphoglyceride catabolic process
has_exact_synonym: phosphoglyceride catabolism
has OBO namespace: biological_process

Axiom
annotated source: glycerophospholipid catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
database_cross_reference: ISBN:0198506732

phosphatidylinositol metabolic process
type: Class
subclass of: glycerophospholipid metabolic process
subclass of: Restriction
  on property: has participant
  some values from: phosphatidylinositol
definition: The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
has_exact_synonym: PtdIns metabolic process
has_exact_synonym: PtdIns metabolism
has_exact_synonym: phosphatidylinositol metabolism
has_exact_synonym: phosphoinositide metabolic process
has_exact_synonym: phosphoinositide metabolism

Axiom
annotated source: phosphatidylinositol metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
database_cross_reference: CHEBI:28874
database_cross_reference: ISBN:0198506732

ceramide biosynthetic process
type: Class
subclass of: lipid biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
has_exact_synonym: ceramide anabolism
has_exact_synonym: ceramide biosynthesis
has_exact_synonym: ceramide formation
has_exact_synonym: ceramide synthesis

ceramide catabolic process
type: Class
subclass of: TXPO_0000071
subclass of: Restriction
  on property: has input
  some values from: ceramide
definition: The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
has_exact_synonym: catabolosm
has_exact_synonym: ceramide breakedown
has_exact_synonym: ceramide degradation

drug export
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: continuant
    intersection of: Restriction
      on property: has role
      some values from: drug
definition: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.

lymphocyte activation
type: Class
subclass of: leukocyte activation
definition: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
database_cross_reference: http://purl.obolibrary.org/obo/IEV_0003879

lymphocyte proliferation
type: Class
subclass of: cell proliferation
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: lymphocyte
    intersection of: Restriction
      on property: has quality
      some values from: PATO_0002002
definition: The expansion of a lymphocyte population by cell division.

negative regulation of insulin secretion
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: insulin secretion
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the release of insulin.

protein autophosphorylation
type: Class
subclass of: phosphorylation
definition: The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

positive regulation of lipid biosynthetic process
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: lipid biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

ketone body biosynthetic process
type: Class
subclass of: TXPO_0000019
subclass of: Restriction
  on property: has output
  some values from: ketone body
definition: ketone body biosynthetic process is a subtype of generating: A process that synthesizes ketone body resulting in having output (s).

HGFR signal transduction pathway
type: Class
subclass of: TXPO_0000609
definition: The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
has_exact_synonym: hepatocyte growth factor receptor signaling pathway

Golgi vesicle transport
type: Class
subclass of: transport
definition: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.

pigment granule
type: Class
subclass of: vesicle
definition: A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.

chemical homeostasis
type: Class
subclass of: homeostatic process
definition: Any biological process involved in the maintenance of an internal steady state of a chemical.

cytokine secretion
type: Class
subclass of: TXPO_0002588
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: continuant
    intersection of: Restriction
      on property: has role
      some values from: TXPO_0000622
definition: The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

Axiom
annotated source: cytokine secretion
annotated property: definition
annotated target: The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
database_cross_reference: ISBN:0198599471

regulation of immune response
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: immune response
definition: Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

response to stimulus
type: Class
subclass of: TXPO_0001984
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.

leukocyte migration
type: Class
subclass of: cell migration
definition: The movement of a leukocyte within or between different tissues and organs of the body.
has_exact_synonym: immune cell migration
has_exact_synonym: immune cell trafficking
has_exact_synonym: leucocyte migration
has_exact_synonym: leucocyte trafficking
has_exact_synonym: leukocyte trafficking

Axiom
annotated source: leukocyte migration
annotated property: definition
annotated target: The movement of a leukocyte within or between different tissues and organs of the body.
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:14680625
database_cross_reference: PMID:14708592
database_cross_reference: PMID:7507411
database_cross_reference: PMID:8600538

positive regulation of lipid catabolic process
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: lipid catabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

regulation of transport (biology)
type: Class
subclass of: TXPO_0003636
subclass of: Restriction
  on property: regulates
  some values from: transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

negative regulation of lipid biosynthetic process
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: lipid biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
has_exact_synonym: down regulation of lipid biosynthetic process
has_exact_synonym: down-regulation of lipid biosynthetic process
has_exact_synonym: downregulation of lipid biosynthetic process
has_exact_synonym: negative regulation of lipid anabolism
has_exact_synonym: negative regulation of lipid biosynthesis
has_exact_synonym: negative regulation of lipid formation

nuclear export
type: Class
subclass of: nuclear transport
subclass of: Restriction
  on property: has target start location
  some values from: nucleus
definition: The directed movement of substances out of the nucleus.
has_exact_synonym: export from nucleus
has_exact_synonym: nucleus export

Axiom
annotated source: nuclear export
annotated property: definition
annotated target: The directed movement of substances out of the nucleus.
database_cross_reference: GO:0051168

nuclear transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: occurs in
  some values from: nucleus
definition: The directed movement of substances into, out of, or within the nucleus.
has_exact_synonym: nucleus transport

import into nucleus
type: Class
subclass of: nuclear transport
subclass of: Restriction
  on property: has target end location
  some values from: nucleus
definition: The directed movement of substances into the nucleus.
has_exact_synonym: nuclear import
has_exact_synonym: nucleus import
has_exact_synonym: substance nuclear import

sequestering of calcium ion
type: Class
subclass of: TXPO_0000247
subclass of: Restriction
  on property: has input
  some values from: calcium ion
definition: The process of binding or confining calcium ions such that they are separated from other components of a biological system.
has_exact_synonym: calcium ion (Ca2+) retention
has_exact_synonym: calcium ion (Ca2+) sequestering
has_exact_synonym: calcium ion (Ca2+) sequestration
has_exact_synonym: calcium ion (Ca2+) storage
has_exact_synonym: retention of calcium ion (Ca2+)
has_exact_synonym: sequestering of calcium ion (Ca2+)
has_exact_synonym: storage of calcium ion (Ca2+)

protein polymerization
type: Class
subclass of: protein complex assembly
definition: The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.

chromosome organization
type: Class
subclass of: TXPO_0002566
editor preferred term: chromosome organization
definition: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
imported from: go.owl

cell division
type: Class
subclass of: TXPO_0002576
subclass of: Restriction
  on property: has input
  some values from: cell
definition: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
database_cross_reference: Wikipedia:Cell_division
database_cross_reference: http://purl.obolibrary.org/obo/IEV_0003382 (obsolete)

G1 phase
type: Class
subclass of: cell cycle phase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: MeSH:D016193

G2 phase
type: Class
subclass of: cell cycle phase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: MeSH:D016195
database_cross_reference: PMID:24885854
database_cross_reference: Wikipedia:G2_phase
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

S phase
type: Class
subclass of: cell cycle phase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: MeSH:D016196

regulation of cell cycle
type: Class
subclass of: TXPO_0000113
subclass of: Restriction
  on property: regulates
  some values from: cell cycle
definition: Any process that modulates the rate or extent of progression through the cell cycle.
has_exact_synonym: cell cycle modulation
has_exact_synonym: cell cycle regulation
has_exact_synonym: control of cell cycle progression
has_exact_synonym: modulation of cell cycle progression
has_exact_synonym: regulation of cell cycle progression
has_exact_synonym: regulation of progression through cell cycle

positive regulation of cell division
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: cell division
definition: Any process that activates or increases the frequency, rate or extent of cell division.
has_exact_synonym: up regulation of cell division

negative regulation of protein kinase B signaling
type: Class
subclass of: negative regulation of signaling
subclass of: Restriction
  on property: negatively regulates
  some values from: protein kinase B signaling
subclass of: Restriction
  on property: negatively regulates
  some values from: TXPO_0001494
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
has_exact_synonym: negative regulation of AKT signalling cascade
has_exact_synonym: negative regulation of PKB signaling cascade
has_exact_synonym: negative regulation of protein kinase B signaling

xenobiotic glucuronidation
type: Class
subclass of: glucuronate metabolic process
definition: The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion.

recycling endosome
type: Class
subclass of: endosome
definition: An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
has_exact_synonym: endosomal recycling compartment
has_related_synonym: ERC
has_related_synonym: endosome recycling compartment

transmembrane transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: occurs in
  some values from: TXPO_0000895
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
has_exact_synonym: membrane transport
comment: Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

maintaining phospholipid homeostasis
type: Class
subclass of: homeostatic process
definition: Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.

oxidation-reduction process
type: Class
subclass of: metabolic process
definition: A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
has_exact_synonym: oxidation reduction
has_exact_synonym: oxidoreductase process

Transdifferentiation
type: Class
subclass of: cell differentiation
definition: The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
database_cross_reference: Wikipedia:Transdifferentiation

positive regulation of phospholipid catabolic process
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: phospholipid catabolic process
definition: Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

membrane organization
type: Class
subclass of: cellular component organization or biogenesis
subclass of: Restriction
  on property: occurs in
  some values from: plasma membrane
definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
has_exact_synonym: cellular membrane organisation

inflammasome complex
type: Class
subclass of: TXPO_0002107
definition: A cytosolic protein complex that is capable of activating caspase-1.

engulfment of target by autophagosome
type: Class
subclass of: membrane invagination
definition: The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.

lysophagy
type: Class
subclass of: autophagy
subclass of: Restriction
  on property: occurs in
  some values from: autophagosome
subclass of: Restriction
  on property: has input
  some values from: lysosome
definition: The selective autophagy process in which a damaged lysosome is degraded by macroautophagy.

protein-containing complex assembly
type: Class
subclass of: TXPO_0003815
subclass of: Restriction
  on property: has input
  some values from: protein
definition: The aggregation, arrangement and bonding together of a set of macromolecules to form a complex.
has_related_synonym: macromolecular complex assembly

protein-lipid complex assembly
type: Class
subclass of: protein-containing complex assembly
subclass of: Restriction
  on property: has input
  some values from: lipid
definition: The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex.

glycosylation
type: Class
subclass of: metabolic process
definition: The covalent attachment and further modification of carbohydrate residues to a substrate molecule.

interleukin-6-mediated signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: IL-6-mediated signaling pathway
has_exact_synonym: interleukin-6-mediated signalling pathway

necrosis
type: Class
subclass of: cell death
definition: A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
has_exact_synonym: cellular necrosis
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.

Axiom
annotated source: necrosis
annotated property: definition
annotated target: A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
database_cross_reference: PMID:18846107
database_cross_reference: PMID:20823910

pyroptosis
type: Class
subclass of: cell death
definition: A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
database_cross_reference: PMID: 21760595
database_cross_reference: PMID:18846107
database_cross_reference: PMID:21760595

Axiom
annotated source: pyroptosis
annotated property: database_cross_reference
annotated target: PMID: 21760595
description: The term ‘pyroptosis' has been introduced in 2000 by Brennan and Cookson to functionally describe the peculiar death of macrophages infected by Salmonella typhimurium. Several other bacterial triggers of this atypical cell death modality have been identified, including Shigella flexneri, Listeria monocytogenes, Pseudomonas aeruginosa, Francisella tularensis and the Bacillus anthracis. However, it has become clear that pyroptosis neither constitutes a macrophage-specific process nor a cell death subroutine that only results from bacterial infection. Of note, pyroptotic cells can exhibit apoptotic and/or necrotic morphological features.

phosphatidic acid binding
type: Class
subclass of: phospholipid binding
definition: Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
database_cross_reference: GO:0070300

Axiom
annotated source: phosphatidic acid binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
database_cross_reference: CHEBI:16337

IL-1 signal transduction pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: IL-1-mediated signaling pathway
has_exact_synonym: interleukin-1-mediated signaling pathway

protein modification by small protein removal
type: Class
subclass of: protein modification by small protein conjugation or removal
definition: A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein.

protein modification by small protein conjugation or removal
type: Class
subclass of: protein modification process
definition: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.

demethylation
type: Class
subclass of: metabolic process
definition: The process of removing one or more methyl groups from a molecule.

positive regulation of phospholipid biosynthetic process
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: phospholipid biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.

transforming growth factor beta production
type: Class
subclass of: cytokine production
editor preferred term: transforming growth factor beta production
definition: The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
imported from: go.owl

chemokine (C-C motif) ligand 4 production
type: Class
subclass of: chemokine production
editor preferred term: chemokine (C-C motif) ligand 4 production
definition: The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

chemokine (C-C motif) ligand 1 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_exact_synonym: CCL1 production
has_exact_synonym: T cell activation 3 production
has_exact_synonym: TCA-3 production

tumor necrosis factor superfamily cytokine production
type: Class
subclass of: cytokine production
editor preferred term: tumor necrosis factor superfamily cytokine production
definition: The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

endoplasmic reticulum-associated degradation
type: Class
subclass of: ERAD pathway
definition: The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
has_exact_synonym: ER-associated misfolded protein breakdown
has_exact_synonym: ER-associated misfolded protein catabolism
has_exact_synonym: ER-associated misfolded protein degradation
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolic process
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolism

cellular component organization or biogenesis
type: Class
subclass of: TXPO_0000134
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.

DNA biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: deoxyribonucleic acid
definition: The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
has_exact_synonym: DNA anabolism
has_exact_synonym: DNA biosynthesis
has_exact_synonym: DNA formation
has_exact_synonym: DNA synthesis

signal transduction by p53 class mediator
type: Class
subclass of: TXPO_0001902
subclass of: Restriction
  on property: has part
  some values from: TXPO_0000237
definition: A series of molecular signals transduced with the regulation of transcription of target genes by p53.

hepatocyte proliferation
type: Class
subclass of: cell proliferation
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: hepatocyte
    intersection of: Restriction
      on property: has quality
      some values from: PATO_0002002
definition: The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
has_related_synonym: hepatocellular hyperplasia

foam cell differentiation
type: Class
subclass of: cell differentiation
definition: The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

endosome to lysosome transport of low-density lipoprotein particle
type: Class
subclass of: cholesterol transport
definition: The directed movement of low-density lipoprotein particle from endosomes to lysosomes.
has_exact_synonym: endosome to lysosome transport of LDL

endoplasmic reticulum membrane organization
type: Class
subclass of: membrane organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts of an endoplasmic reticulum membrane.

cellular senescence
type: Class
subclass of: TXPO_0000392
definition: A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

intrinsic apoptotic signaling pathway
type: Class
subclass of: TXPO_0000609
definition: A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).

apoptosome assembly
type: Class
subclass of: protein complex assembly
definition: The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process.

chemokine (C-X-C motif) ligand 12 production
type: Class
subclass of: chemokine production
editor preferred term: chemokine (C-X-C motif) ligand 12 production
definition: The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
imported from: go.owl

feroptosis
type: Class
subclass of: cell death
definition: A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
database_cross_reference: pmid:25236395
database_cross_reference: pmid:26794443

detoxification
type: Class
subclass of: TXPO_0000458
definition: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.

inner mitochondrial membrane protein complex
type: Class
subclass of: TXPO_0002107
definition: Any protein complex that is part of the inner mitochondrial membrane.

cellular oxidant detoxification
type: Class
subclass of: cellular detoxification
definition: Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.

plasma membrane invagination
type: Class
subclass of: membrane invagination
definition: An infolding of the plasma membrane.

positive regulation of cellular response to oxidative stress
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: occurs in
  some values from: cell
subclass of: Restriction
  on property: positively regulates
  some values from: response to oxidative stress
definition: Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress.

regulation of mitophagy
type: Class
subclass of: regulation of autophagy
subclass of: Restriction
  on property: regulates
  some values from: mitohagy
definition: Any process that modulates the frequency, rate or extent of macromitophagy.

positive regulation of mitophagy
type: Class
subclass of: regulation of mitophagy
subclass of: Restriction
  on property: positively regulates
  some values from: mitohagy
definition: Any process that activates or increases the frequency, rate or extent of mitophagy.

fatty acid derivative binding
type: Class
subclass of: binding (with molecule)
subclass of: Restriction
  on property: has input
  some values from: fatty acid derivative
definition: Interacting selectively and non-covalently with fatty acid derivative.

phosphatidylglycerol binding
type: Class
subclass of: phospholipid binding
definition: Interacting selectively and non-covalently with phosphatidylglycerol.
database_cross_reference: GO:1901611

negative regulation of p53 signaling
type: Class
subclass of: negative regulation of signaling
subclass of: Restriction
  on property: negatively regulates
  some values from: epidermal growth factor receptor signaling pathway
subclass of: Restriction
  on property: negatively regulates
  some values from: TXPO_0000001
definition: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
has_exact_synonym: downregulation of signal transduction by p53 class mediator

negative regulation of proteasomal protein catabolic process
type: Class
subclass of: negative regulation of protein catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: proteasomal protein catabolic process
definition: Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.

negative regulation of cell junction assembly
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: cell junction assembly
definition: Negative regulation of cell junction assembly is a subtype of negative regulation process: Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.
has_narrow_synonym: inhibition of cell junction assembly

cell cycle DNA replication initiation
type: Class
subclass of: TXPO_0001984
definition: Any DNA replication initiation that is involved in cell cycle DNA replication.
has_exact_synonym: DNA replication initiation involved in cell cycle DNA replication
has_exact_synonym: DNA-dependent DNA replication initiation involved in cell cycle DNA replication

negative regulation of nuclear cell cycle DNA replication
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: DNA replication
definition: Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication.
has_exact_synonym: down regulation of DNA replication involved in S phase

proton transmembrane transport
type: Class
subclass of: ion transport
definition: The directed movement of a proton across a membrane.

negative regulation of mitochondrial electron transport, NADH to ubiquinone
type: Class
subclass of: TXPO_0002342
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
subclass of: Restriction
  on property: negatively regulates
  some values from: mitochondrial electron transport, NADH to ubiquinone
definition: Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.

reactive oxygen species biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: has output
  some values from: reactive oxygen species
definition: The chemical reaction resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
has_exact_synonym: reactive oxygen species biosynthesis
has_exact_synonym: reactive oxygen species formation
has_exact_synonym: reactive oxygen species synthesis

Axiom
annotated source: reactive oxygen species biosynthetic process
annotated property: has_exact_synonym
annotated target: reactive oxygen species synthesis
database_cross_reference: PMID:24252804

negative regulation of ROS formation
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: reactive oxygen species biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ROS.
has_exact_synonym: negative regulation of reactive oxygen species biosynthetic process

negative regulation of gap junction assembly
type: Class
subclass of: negative regulation of cell junction assembly
subclass of: Restriction
  on property: negatively regulates
  some values from: gap junction assembly
definition: Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly.

positive regulation of glutathione biosynthetic process
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: glutathione biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.
has_exact_synonym: positive regulation of glutathione anabolism
has_exact_synonym: positive regulation of glutathione biosynthesis
has_exact_synonym: positive regulation of glutathione formation
has_exact_synonym: positive regulation of glutathione synthesis
has_exact_synonym: up regulation of glutathione anabolism
has_exact_synonym: up regulation of glutathione biosynthesis

positive regulation of ERAD
type: Class
subclass of: positive regulation of proteolysis
subclass of: Restriction
  on property: positively regulates
  some values from: ERAD pathway
definition: Any process that activates or increases the frequency, rate or extent of ERAD pathway.

positive regulation of protein refolding
type: Class
subclass of: TXPO_0001223
subclass of: Restriction
  on property: positively regulates
  some values from: protein refolding
definition: Any process that activates or increases the frequency, rate or extent of protein refolding.
has_exact_synonym: up regulation of protein refolding
has_exact_synonym: up-regulation of protein refolding
has_exact_synonym: upregulation of protein refolding

macrophage migration
type: Class
subclass of: leukocyte migration
definition: The orderly movement of a macrophage from one site to another.

cellular detoxification
type: Class
subclass of: detoxification
subclass of: Restriction
  on property: occurs in
  some values from: cell
definition: Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.

hepatic stellate cell proliferation
type: Class
subclass of: cell proliferation
subclass of: Restriction
  on property: has input
  some values from: hepatic stellate cell
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: hepatic stellate cell
    intersection of: Restriction
      on property: has quality
      some values from: PATO_0002002
definition: The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver.
has_exact_synonym: Ito cell proliferation
has_exact_synonym: hepatic perisinusoidal cell proliferation
has_exact_synonym: perisinusoidal cell proliferation

negative regulation of cellular senescence
type: Class
subclass of: TXPO_0000369
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular senescence
definition: Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.

Activation, translocation and oligomerization of BAX
type: Class
subclass of: TXPO_0003222
description: As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
database_cross_reference: Reactome:R-HSA-114294.2

Axiom
annotated source: Activation, translocation and oligomerization of BAX
annotated property: description
annotated target: As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
source: Reactome

Activation and oligomerization of BAK protein
type: Class
subclass of: TXPO_0003222
description: tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.
database_cross_reference: Reactome:R-HSA-114294.2

Activation of BH3-only proteins
type: Class
subclass of: TXPO_0003222

amino acid conjugation
type: Class
subclass of: cellular amino acid metabolic process
definition: Xenobiotics that contain either a carboxylic group or an aromatic hydroxylamine group are possible substrates for amino acid conjugation. Xenobiotics with a carboxylic group conjugate with an amino group of amino acids such as glycine, taurine and glutamine. The hydroxylamine group conjugates with the carboxylic group of amino acids such as proline and serine.

Glutathione synthesis and recycling
type: Class
subclass of: TXPO_0000610
definition: The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).
database_cross_reference: PMID:3053703
database_cross_reference: Reactome: R-HSA-174403.4

Axiom
annotated source: Glutathione synthesis and recycling
annotated property: database_cross_reference
annotated target: Reactome: R-HSA-174403.4
database_cross_reference: https://reactome.org/PathwayBrowser/

Translocation of NF-kappaB from the cytosol to the nucleus
type: Class
subclass of: TXPO_0002494
subclass of: Restriction
  on property: has output
  some values from: TXPO_0002769
definition: Transport of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

Phenotypic abnormality
type: Class
subclass of: quality
definition: A phenotypic abnormality.

edema
type: Class
subclass of: Phenotypic abnormality
definition: An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
has_exact_synonym: Dropsy
has_exact_synonym: Fluid retention
has_exact_synonym: Hydrops
has_exact_synonym: Oedema
has_exact_synonym: Water retention

Hyperglycemia
type: Class
subclass of: PATO_0001162
definition: An increased concentration of glucose in the blood.
has_exact_synonym: High blood glucose
has_exact_synonym: High blood sugar

information content entity
type: Class
subclass of: generically dependent continuant
definition: A generically dependent continuant that is about some thing.

measurement datum
type: Class
subclass of: TXPO_0000614
definition: A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.

Wnt
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
database_cross_reference: GO:0005110

hedgehog
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
database_cross_reference: GO:0005113
has_exact_synonym: Hh

SHH (mol)
type: Class
subclass of: hedgehog
database_cross_reference: NCBI-Human-GeneID:6469
database_cross_reference: NCBI-Mouse-GeneID:20423
database_cross_reference: NCBI-Rat-GeneID:29499
has_exact_synonym: HHG-1
has_exact_synonym: Sonic hedgehog

Axiom
annotated source: SHH (mol)
annotated property: database_cross_reference
annotated target: NCBI-Human-GeneID:6469
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/6469

Axiom
annotated source: SHH (mol)
annotated property: database_cross_reference
annotated target: NCBI-Mouse-GeneID:20423
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/20423

Axiom
annotated source: SHH (mol)
annotated property: database_cross_reference
annotated target: NCBI-Rat-GeneID:29499
comment: https://www.ncbi.nlm.nih.gov/gene/29499

Interleukin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
subclass of: Restriction
  on property: family of
  some values from: Interleukin
has_exact_synonym: IL

IL-2
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005134
has_exact_synonym: Interleukin-2
has_exact_synonym: TCGF

IL-5
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005137
has_exact_synonym: interleukin-5

IL-6 (mol)
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005138
has_exact_synonym: interleukin-6

IL-1 (mol)
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005149
has_exact_synonym: interleukin-1

IL-3
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005135
has_exact_synonym: interleukin-3

IL-11
type: Class
subclass of: Interleukin
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005142
has_exact_synonym: interleukin-11

TPO
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000155
database_cross_reference: Wikipedia:Thrombopoietin
has_exact_synonym: thrombopoietin

EPO
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000155
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005128
database_cross_reference: OMIM: 133170
database_cross_reference: Wikipedia:Erythropoietin
has_exact_synonym: erythropoietin

G-CSF
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
has_exact_synonym: granulocyte colony-stimulating factor
comment: related molecular function GO:0005130

GM-CSF
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: OMIM: 138960
has_exact_synonym: granulocyte-macrophage colony-stimulating factor
comment: relate molecular function GO:0005129

LIF
type: Class
subclass of: IL-6 (mol)
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: OMIM: 159540
has_exact_synonym: leukemia inhibitory factor

SCF
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000155
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: OMIM: 184745
database_cross_reference: Wikipedia:Stem_cell_factor
database_cross_reference: related molecular function GO:0005173
has_exact_synonym: stem cell factor

TNF superfamily
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
database_cross_reference: GO:0005164
database_cross_reference: IPR:006052

FasL
type: Class
subclass of: TNF superfamily
has_exact_synonym: CD178 antigen
has_exact_synonym: CD95L
has_exact_synonym: Fas ligand
has_exact_synonym: FasL
has_exact_synonym: Tumor necrosis factor ligand superfamily member 6

CD40L
type: Class
subclass of: TNF superfamily
database_cross_reference: GO:0005174
has_exact_synonym: CD154
has_exact_synonym: CD40 ligand
has_exact_synonym: gp39

TNF alpha
type: Class
subclass of: TNF superfamily
has_exact_synonym: TNF
has_exact_synonym: tumor necrosis factor alpha

LT alpha
type: Class
subclass of: TNF superfamily
has_exact_synonym: TNF beta
has_exact_synonym: lymphotoxin
has_exact_synonym: lymphotoxin alpha

Interferon
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000622
has_exact_synonym: IFN

IFN type I
type: Class
subclass of: Interferon
database_cross_reference: GO:0005132
has_exact_synonym: type I Interferon

IFN type II
type: Class
subclass of: Interferon
database_cross_reference: GO:0005133
has_exact_synonym: type II Interferon

VEGF (mol)
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005172
database_cross_reference: NCBI-Human-GeneID:7422
database_cross_reference: NCBI-Mouse-GeneID:22339
database_cross_reference: NCBI-Rat-GeneID:83785
has_exact_synonym: VEGFA
has_exact_synonym: vascular endothelial growth factor

Axiom
annotated source: VEGF (mol)
annotated property: database_cross_reference
annotated target: NCBI-Human-GeneID:7422
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/7422

Axiom
annotated source: VEGF (mol)
annotated property: database_cross_reference
annotated target: NCBI-Mouse-GeneID:22339
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/22339

Axiom
annotated source: VEGF (mol)
annotated property: database_cross_reference
annotated target: NCBI-Rat-GeneID:83785
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/83785

PDGF
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005161
has_exact_synonym: platelet derived growth factor

HGF
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005171
has_exact_synonym: hepatocyte growth factor
has_exact_synonym: scatter factor

NGF family
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005165
has_exact_synonym: nerve growth factor family
has_exact_synonym: neurotrophin

type I cytokeratin
type: Class
subclass of: keratin
has_exact_synonym: acidic cytokeratin

TGF-beta superfamily
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
definition: The TGF-beta superfamily of growth factors regulate many cellular functions, which includes TGF-betas, activins and inhibins, nodal, BMPs and GDFs. TGF-beta/BMP-like proteins are found in various species, including Xenopus, C.elegans and D.melanogaster.
database_cross_reference: GO:0005160
has_exact_synonym: transforming growth factor beta superfamily

Axiom
annotated source: TGF-beta superfamily
annotated property: definition
annotated target: The TGF-beta superfamily of growth factors regulate many cellular functions, which includes TGF-betas, activins and inhibins, nodal, BMPs and GDFs. TGF-beta/BMP-like proteins are found in various species, including Xenopus, C.elegans and D.melanogaster.
database_cross_reference: PMID:12485160
database_cross_reference: PMID:18000526
database_cross_reference: PMID:9759503

inhibin
type: Class
subclass of: TGF-beta superfamily
database_cross_reference: GO:0016916

activin
type: Class
subclass of: TGF-beta superfamily
database_cross_reference: GO:0016915

BMP family
type: Class
subclass of: TGF-beta superfamily
definition: BMPs belong to the TGF-beta superfamily. BMP-like molecules have been identified in various species including D.melanogaster (Dpp, Gbb/60A and Scw) and C.elegans.
has_exact_synonym: Bone morphogenetic protein family

Axiom
annotated source: BMP family
annotated property: definition
annotated target: BMPs belong to the TGF-beta superfamily. BMP-like molecules have been identified in various species including D.melanogaster (Dpp, Gbb/60A and Scw) and C.elegans.
database_cross_reference: PMID:15871923
database_cross_reference: PMID:9720756
database_cross_reference: PMID:9759503

TGF-beta family
type: Class
subclass of: TGF-beta superfamily
database_cross_reference: GO:0005160

TGF-beta1
type: Class
subclass of: TGF-beta family
database_cross_reference: GO:0005160
has_exact_synonym: transforming growth factor-beta 1

TGF-beta2
type: Class
subclass of: TGF-beta family
database_cross_reference: GO:0005160
has_exact_synonym: transforming growth factor-beta 2

TGF-beta3
type: Class
subclass of: TGF-beta family
database_cross_reference: GO:0005160
has_exact_synonym: transforming growth factor-beta 3

GDNF
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005160
has_exact_synonym: Glial cell line-derived neurotrophic factor

Nodal family
type: Class
subclass of: TGF-beta superfamily

EGF family
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
has_exact_synonym: epidermal growth factor family

neuregulin
type: Class
subclass of: EGF family
has_exact_synonym: NRG

FGF
type: Class
subclass of: TXPO_0001382
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000624
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002395
database_cross_reference: GO:0005104
has_exact_synonym: Fibroblast growth factor
has_exact_synonym: HBGF
has_exact_synonym: Heparin-binding growth factor

type II cytokeratin
type: Class
subclass of: keratin
has_exact_synonym: neutral to basic cytokeratin

leptin
type: Class
subclass of: IMR_0000966
subclass of: Restriction
  on property: has role
  some values from: hormone

insulin
type: Class
subclass of: IMR_0002835
subclass of: Restriction
  on property: family of
  some values from: IMR_0002835
definition: A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus.
has_alternative_id: IMR:0010309
has_alternative_id: IMR:0011543
has_alternative_id: IMR:0011922
database_cross_reference: GO:0016088
database_cross_reference: MeSH:D007328
has_exact_synonym: Humulin
has_exact_synonym: Insulin precursor
has_exact_synonym: insulin A chain
has_exact_synonym: insulin B chain
has_exact_synonym: insulin fragments

Axiom
annotated source: insulin
annotated property: definition
annotated target: A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus.
database_cross_reference: MeSH:D007328

cytokeratin 1
type: Class
subclass of: type II cytokeratin

TNFR family
type: Class
subclass of: molecule
database_cross_reference: GO:0005027
has_exact_synonym: tumor necrosis factor receptor family

CD40
type: Class
subclass of: TNFR family
database_cross_reference: GO:0005028

FasR
type: Class
subclass of: TNFR family
has_exact_synonym: Apo-1
has_exact_synonym: CD95
has_exact_synonym: Fas receptor

TNFR1
type: Class
subclass of: IMR_0100674
database_cross_reference: GO:0005032
has_exact_synonym: tumor necrosis factor receptor, type I

TNFR2
type: Class
subclass of: IMR_0100674
database_cross_reference: GO:0005033
has_exact_synonym: tumor necrosis factor receptor, type II

PDGF receptor
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000823
database_cross_reference: GO:0005017
has_exact_synonym: platelet derived growth factor receptor

alpha PDGF receptor
type: Class
subclass of: PDGF receptor
database_cross_reference: GO:0005018
has_exact_synonym: alpha platelet derived growth factor receptor

beta PDGF receptor
type: Class
subclass of: PDGF receptor
database_cross_reference: GO:0005019
has_exact_synonym: beta platelet derived growth factor receptor

insulin receptor family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000823

ALK
type: Class
subclass of: insulin receptor family
has_exact_synonym: anaplastic lymphoma kinase

LTK
type: Class
subclass of: insulin receptor family
has_exact_synonym: leukocyte tyrosine kinase

insulin receptor
type: Class
subclass of: insulin receptor family
has_alternative_id: IMR:0010308
has_alternative_id: IMR:0011304
has_alternative_id: IMR:0011542
database_cross_reference: GO:0005009
has_exact_synonym: CD220 antigen
has_exact_synonym: IR
has_exact_synonym: insulin receptor alpha subunit
has_exact_synonym: insulin receptor beta subunit
has_exact_synonym: insulin receptor precursor

FGFR family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000823
definition: The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4.
database_cross_reference: GO:0005007
has_exact_synonym: fibroblast growth factor receptor

Axiom
annotated source: FGFR family
annotated property: definition
annotated target: The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4.
database_cross_reference: PMID:15689573

EGFR (mol)
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000823
database_cross_reference: GO:0005006
has_exact_synonym: epidermal growth factor receptor

IP3 receptor
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002628
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003161
database_cross_reference: GO:0008095
has_exact_synonym: IP3R
has_exact_synonym: inositol-1,4,5-triphosphate receptor

TR
type: Class
subclass of: TXPO_0001509
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003224
database_cross_reference: GO:0004887
has_exact_synonym: c-erbA
has_exact_synonym: thyroid hormone receptor

cytokeratin 3
type: Class
subclass of: type II cytokeratin

Estrogen receptor
type: Class
subclass of: TXPO_0001509
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003224

PPAR
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003224
definition: transcription factors that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
database_cross_reference: http://purl.bioontology.org/ontology/MESH/D047492
has_exact_synonym: Peroxisome proliferator activated receptor

RAR
type: Class
subclass of: TXPO_0001509
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003224
has_exact_synonym: Retinoic acid receptor

TGF-beta receptor
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002154
database_cross_reference: GO:0005024
has_exact_synonym: Transforming growth factor-beta receptor

TGF-beta receptor type I
type: Class
subclass of: TGF-beta receptor
database_cross_reference: GO:0005025
has_exact_synonym: Transforming growth factor-beta receptor type I

TGF-beta receptor type II
type: Class
subclass of: TGF-beta receptor
database_cross_reference: GO:0005026
has_exact_synonym: Transforming growth factor-beta receptor type II

interleukin receptor
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003331
database_cross_reference: GO:0004907

IL-2 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004911
has_exact_synonym: interleukin-2 receptor

IL-5 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004914
has_exact_synonym: interleukin-5 receptor

IL-6 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004915
has_exact_synonym: interleukin-6 receptor

IL-4 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004913
has_exact_synonym: interleukin-4 receptor

IL-3 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004912
has_exact_synonym: interleukin-3 receptor

IL-7 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004917
has_exact_synonym: interleukin-7 receptor

IL-9 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004919
has_exact_synonym: interleukin-9 receptor

IL-13 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0016515
has_exact_synonym: interleukin-13 receptor

IL-15 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0042010
has_exact_synonym: interleukin-15 receptor

IL-1 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0004908
has_exact_synonym: interleukin-1 receptor

IL-18 receptor
type: Class
subclass of: interleukin receptor
database_cross_reference: GO:0042008
has_exact_synonym: IL-1Rrp
has_exact_synonym: IL1 receptor-related protein
has_exact_synonym: Interleukin-18 receptor

TLR
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003441
has_exact_synonym: Toll-like receptor

leptin receptor
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003331
has_exact_synonym: OB-R

IFNR
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003331
database_cross_reference: GO:0004904
has_exact_synonym: interferon receptor

IFNR type I
type: Class
subclass of: IFNR
database_cross_reference: GO:0004905
has_exact_synonym: IFNAR
has_exact_synonym: Interferon alpha/beta receptor

IFNR type II
type: Class
subclass of: IFNR
database_cross_reference: GO:0004906
has_exact_synonym: IFNGR
has_exact_synonym: Interferon-gamma receptor

MHC family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003691
database_cross_reference: GO:0042611
has_exact_synonym: major histocompatibility complex

MHC class I molecule
type: Class
subclass of: MHC family
definition: MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin.
database_cross_reference: GO:0042612
has_exact_synonym: MHC class Ia molecule
has_exact_synonym: classical MHC class I molecule
has_exact_synonym: major histocompatibility complex class I molecule

Axiom
annotated source: MHC class I molecule
annotated property: definition
annotated target: MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin.
database_cross_reference: ISBN:0815340729
database_cross_reference: PMID:10607669
database_cross_reference: PMID:16860610

MHC class II molecule
type: Class
subclass of: MHC family
definition: MHC class II molecules are composed of membrane-spanning alpha and beta chains.
database_cross_reference: GO:0042613
has_exact_synonym: classical MHC class II molecule
has_exact_synonym: major histocompatibility complex class II molecule

Axiom
annotated source: MHC class II molecule
annotated property: definition
annotated target: MHC class II molecules are composed of membrane-spanning alpha and beta chains.
database_cross_reference: ISBN:0815340729
database_cross_reference: PMID:10607669

cytokeratin 4
type: Class
subclass of: type II cytokeratin

TCR family
type: Class
subclass of: molecule
has_exact_synonym: T-cell receptor

BCR
type: Class
subclass of: molecule
database_cross_reference: GO:0019815
has_exact_synonym: B cell receptor
has_exact_synonym: B cell receptor complex
has_exact_synonym: B-cell antigen receptor
has_exact_synonym: BCR complex

FcR
type: Class
subclass of: molecule

FcepsilonRI
type: Class
subclass of: FcR

FcgammaRI
type: Class
subclass of: FcR
has_exact_synonym: High affinity immunoglobulin gamma Fc receptor I

FcgammaRIII
type: Class
subclass of: FcR
has_exact_synonym: Low affinity immunoglobulin gamma FC region receptor III

FcgammaRII
type: Class
subclass of: FcR
has_exact_synonym: Low affinity immunoglobulin gamma Fc region receptor II

cytokeratin 5
type: Class
subclass of: type II cytokeratin

cytokeratin 7
type: Class
subclass of: type II cytokeratin

cytokeratin 8
type: Class
subclass of: type II cytokeratin

cytokeratin 6A
type: Class
subclass of: IMR_0000469
has_alternative_id: IMR:0000260
has_exact_synonym: cytokeratin 6D

cadherin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688

E-cadherin
type: Class
subclass of: cadherin
has_exact_synonym: Arc-1
has_exact_synonym: Epithelial-cadherin
has_exact_synonym: L-CAM
has_exact_synonym: Uvomorulin
has_exact_synonym: cadherin-1
has_exact_synonym: cell-CAM120/80

N-cadherin
type: Class
subclass of: cadherin
has_exact_synonym: A-CAM
has_exact_synonym: Neural-cadherin
has_exact_synonym: cadherin-2

R-cadherin
type: Class
subclass of: cadherin
has_exact_synonym: Retinal-cadherin
has_exact_synonym: cadherin-4

VE-cadherin
type: Class
subclass of: cadherin
has_exact_synonym: Vascular endothelial-cadherin
has_exact_synonym: cadherin-5

integrin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688
definition: Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties.

Axiom
annotated source: integrin
annotated property: definition
annotated target: Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties.
database_cross_reference: PMID:10446041

Integrin alpha
type: Class
subclass of: integrin

Integrin beta
type: Class
subclass of: integrin

alpha-catenin
type: Class
subclass of: TXPO_0003158
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688

beta-catenin
type: Class
subclass of: TXPO_0003158
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000330
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688
comment: named 'beta-catenin family' formerly.

ICAM
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688
has_exact_synonym: intercellular adhesion molecule

N-CAM
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003688
has_exact_synonym: neuronal cell adhesion molecule

paxillin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: actin cytoskeleton protein
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003657

actin cytoskeleton protein
type: Class
subclass of: TXPO_0003689
definition: A role played by the protein contributes to the integrity of the actin cytoskeleton.
database_cross_reference: IMR:0000188 (obsolete)
has_exact_synonym: actin filament cytoskeletal protein
comment: related cellular component GO:0015629

alpha-actinin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: actin cytoskeleton protein

actin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003692

myosin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: actin cytoskeleton protein
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003690

tropomyosin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: actin cytoskeleton protein

troponin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: actin cytoskeleton protein

kinesin
type: Class
subclass of: IMR_0100192

dynein
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000186
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003690

keratin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003693
has_exact_synonym: cytokeratin

neurofilament protein
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003693
database_cross_reference: GO:0005883

dystrophin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003689

APC
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003689
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003721
has_exact_synonym: Adenomatous Polyposis Coli Protein

ankyrin
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003689

cytokeratin 6B
type: Class
subclass of: IMR_0000469
has_alternative_id: IMR:0000302
has_exact_synonym: cytokeratin 6F

Src family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001054
database_cross_reference: MeSH:D019061

Csk
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001054
has_exact_synonym: C-terminal Src kinase

JAK
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001054
definition: Janus kinases (Jaks) are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). In Drosophila there is only one Jak kinase, Hopscotch (Hop).
database_cross_reference: GO:0004718
has_exact_synonym: Janus kinase

Axiom
annotated source: JAK
annotated property: definition
annotated target: Janus kinases (Jaks) are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). In Drosophila there is only one Jak kinase, Hopscotch (Hop).
database_cross_reference: PMID:15575979

Fak/Pyk2
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001054

Fak
type: Class
subclass of: Fak/Pyk2
database_cross_reference: GO:0004717
has_exact_synonym: Focal adhesion kinase

Pyk2
type: Class
subclass of: Fak/Pyk2
has_exact_synonym: CADTK
has_exact_synonym: Cak beta
has_exact_synonym: RAFTK
has_exact_synonym: calcium-dependent tyrosine kinase
has_exact_synonym: cell adhesion kinase beta
has_exact_synonym: prolin-rich tyrosine kinase 2
has_exact_synonym: related adhesion focal tyrosine kinase

ZAP-70/Syk
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001054

ZAP-70
type: Class
subclass of: ZAP-70/Syk

Syk
type: Class
subclass of: ZAP-70/Syk
has_exact_synonym: Spleen tyrosine kinase

MAPK
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
definition: Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif.
database_cross_reference: GO:0004707
database_cross_reference: IPR:003527
has_exact_synonym: MAP kinase
has_exact_synonym: mitogen-activated protein kinase

Axiom
annotated source: MAPK
annotated property: definition
annotated target: Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif.
database_cross_reference: PMID:11242034
database_cross_reference: PMID:9922370

JNK/SAPK
type: Class
subclass of: MAPK
database_cross_reference: GO:0016909
database_cross_reference: IPR:008351
has_exact_synonym: c-jun N-terminal kinase
has_exact_synonym: stress-activated protein kinase

p38
type: Class
subclass of: MAPK
database_cross_reference: IPR:008352

ERK1/2
type: Class
subclass of: MAPK
definition: ERK1 and ERK2 are isoforms of the 'classical' MAPK. Both ERK1 and ERK2 (referred to as ERK1/2) are activated by MAP/ERK kinase 1 (MEK1) and MEK2 (referred to as MEK1/2). MEK1/2 phosphorylates threonine and tyrosine residues in the Thr-Glu-Tyr (TEY) sequence of ERK1/2. Activated ERK1/2 phosphorylates many substrates including transcription factors, such as Elk1 and c-Myc, and protein kinases, such as ribosomal S6 kinase (RSK).
database_cross_reference: IPR:008349
has_exact_synonym: ERK
has_exact_synonym: Extracellular signal-regulated kinase
has_exact_synonym: MAPK/ERK
has_exact_synonym: p42/p44 MAP kinase
has_exact_synonym: p42/p44 MAPK

Axiom
annotated source: ERK1/2
annotated property: definition
annotated target: ERK1 and ERK2 are isoforms of the 'classical' MAPK. Both ERK1 and ERK2 (referred to as ERK1/2) are activated by MAP/ERK kinase 1 (MEK1) and MEK2 (referred to as MEK1/2). MEK1/2 phosphorylates threonine and tyrosine residues in the Thr-Glu-Tyr (TEY) sequence of ERK1/2. Activated ERK1/2 phosphorylates many substrates including transcription factors, such as Elk1 and c-Myc, and protein kinases, such as ribosomal S6 kinase (RSK).
database_cross_reference: PMID:16880823

MAPKKK
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
database_cross_reference: GO:0004709
has_exact_synonym: MAP kinase kinase kinase
has_exact_synonym: MAPKK kinase
has_exact_synonym: MKKK

mos
type: Class
subclass of: MAPKKK
has_exact_synonym: c-mos

Raf
type: Class
subclass of: MAPKKK

TAK1
type: Class
subclass of: MAPKKK
has_exact_synonym: MOM-4
has_exact_synonym: TGF-bata activated kinase 1

Tpl2
type: Class
subclass of: MAPKKK
has_exact_synonym: Cot
has_exact_synonym: Est
has_exact_synonym: Tumor progression locus 2
has_exact_synonym: cancer Osaka thyroid oncogene

MEKK
type: Class
subclass of: MAPKKK
database_cross_reference: GO:0004710
has_exact_synonym: MAPK/ERK kinase kinase

PAK
type: Class
subclass of: MAPKKK
subclass of: Ste20 homolog family

MLK family
type: Class
subclass of: MAPKKK

NIK
type: Class
subclass of: MAPKKK
database_cross_reference: GO:0004704
has_exact_synonym: NF-kappa B-inducing kinase

IKK complex
type: Class
subclass of: TXPO_0002107
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
database_cross_reference: GO:0008385
has_exact_synonym: I-kappaB kinase complex

cytokeratin 6C
type: Class
subclass of: IMR_0000469
has_alternative_id: IMR:0000270
has_exact_synonym: cytokeratin 6E

PKC
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
database_cross_reference: GO:0004697
has_exact_synonym: protein kinase C

nPKC
type: Class
subclass of: PKC
definition: novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids.
has_exact_synonym: novel protein kinase C

Axiom
annotated source: nPKC
annotated property: definition
annotated target: novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids.
database_cross_reference: PMID:15282562

aPKC
type: Class
subclass of: PKC
definition: atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG.
database_cross_reference: GO:0004700
has_exact_synonym: atypical protein kinase C

Axiom
annotated source: aPKC
annotated property: definition
annotated target: atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG.
database_cross_reference: PMID:15282562

RSK
type: Class
subclass of: IMR_0001844
subclass of: IMR_0100271
definition: A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway.
database_cross_reference: GO:0004711
has_exact_synonym: 90 kDa ribosomal S6 kinase
has_exact_synonym: MAPK-activated protein kinase-1
has_exact_synonym: MAPKAP kinase-1
has_exact_synonym: MAPKAP-K1
has_exact_synonym: p90rsk

Axiom
annotated source: RSK
annotated property: definition
annotated target: A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway.
database_cross_reference: PMID:10411321

PKA
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
definition: PKA is comprised of two types of subunits. Two catalytic (C) subunits bind to a regulatory (R) subunit dimer to form an inactive holoenzyme complex. Binding of cAMP to the regulatory subunit causes the catalytic subunit to be unleashed.
database_cross_reference: GO:0004691
database_cross_reference: GO:0005952
has_exact_synonym: cAMP-dependent protein kinase
has_exact_synonym: protein kinase A

Axiom
annotated source: PKA
annotated property: definition
annotated target: PKA is comprised of two types of subunits. Two catalytic (C) subunits bind to a regulatory (R) subunit dimer to form an inactive holoenzyme complex. Binding of cAMP to the regulatory subunit causes the catalytic subunit to be unleashed.
database_cross_reference: PMID:17996741

Akt
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
has_exact_synonym: PKB
has_exact_synonym: RAC serine/threonine protein kinase
has_exact_synonym: RAC-PK
has_exact_synonym: protein kinase B

PKG
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
database_cross_reference: GO:0004692
has_exact_synonym: cGMP-dependent protein kinase

Ste20 homolog family
type: Class
subclass of: IMR_0100207

mammalian Ste20-like kinases (MAPKKKK)
type: Class
subclass of: Ste20 homolog family

G-protein coupled receptor kinase
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966

PDK
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
has_alternative_id: IMR:0010402
has_exact_synonym: 3-phosphoinositide dependent protein kinase-1
has_exact_synonym: hPDK1
has_exact_synonym: phosphatidylinositol-dependent kinase

Plk
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
has_exact_synonym: polo-like kinase

GSK3
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
database_cross_reference: GO:0004696
has_exact_synonym: glycogen synthase kinase 3

MAPKK
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0002002
database_cross_reference: GO:0004708
has_exact_synonym: MAP kinase kinase
has_exact_synonym: MAPK kinase

MEK1/2(MKK1/2)
type: Class
subclass of: MAPKK
definition: MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases.
has_exact_synonym: MAPKK1/2
has_exact_synonym: MEK
has_exact_synonym: MEK1/2
has_exact_synonym: MKK1/2

Axiom
annotated source: MEK1/2(MKK1/2)
annotated property: definition
annotated target: MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases.
database_cross_reference: PMID:11242034
database_cross_reference: PMID:9922370

MKK4/7(JNKK1/2)
type: Class
subclass of: MAPKK
definition: MKK4 and MKK7 phosphorylate and activate JNK MAP kinases.

Axiom
annotated source: MKK4/7(JNKK1/2)
annotated property: definition
annotated target: MKK4 and MKK7 phosphorylate and activate JNK MAP kinases.
database_cross_reference: PMID:11242034
database_cross_reference: PMID:9922370

MKK3/6
type: Class
subclass of: MAPKK
definition: MKK3 and MKK6 phosphorylate and activate p38 MAP kinases.

Axiom
annotated source: MKK3/6
annotated property: definition
annotated target: MKK3 and MKK6 phosphorylate and activate p38 MAP kinases.
database_cross_reference: PMID:11242034
database_cross_reference: PMID:9922370

PI3-kinase
type: Class
subclass of: TXPO_0003223
database_cross_reference: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
database_cross_reference: GO:0016303
has_exact_synonym: PI3K
has_exact_synonym: phosphatidylinositol 3-kinase

PI3-kinase p85 subunit
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003722
has_exact_synonym: Phosphatidylinositol 3-kinase p85 regulatory subunit

PI3-kinase p110 subunit
type: Class
subclass of: TXPO_0003223
has_exact_synonym: Phosphatidylinositol 3-kinase p110 catalytic subunit

RIP
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0001966
has_exact_synonym: Receptor interacting protein
has_exact_synonym: Receptor-interacting serine/threonine protein kinase

SHIP
type: Class
subclass of: molecule
has_exact_synonym: Src homology-2 domain-containing inositol 5'-phosphatase

SHP family
type: Class
subclass of: molecule

SHP-1
type: Class
subclass of: SHP family
has_exact_synonym: HCP
has_exact_synonym: PTP1C
has_exact_synonym: SH-PTP1
has_exact_synonym: Src homology 2-containing protein tyrosine phosphatase-1

SHP-2
type: Class
subclass of: SHP family
has_exact_synonym: PTP1D
has_exact_synonym: SH-PTP2
has_exact_synonym: Src homology 2-containing protein tyrosine phosphatase-2
has_exact_synonym: Syp

PLA2 (mol)
type: Class
subclass of: TXPO_0000635
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003671
subclass of: Restriction
  on property: family of
  some values from: PLA2 (mol)
definition: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
database_cross_reference: EC:3.1.1.4
database_cross_reference: GO:0004623
database_cross_reference: PMID:30077006
has_exact_synonym: phospholipase A2

PLC (mol)
type: Class
subclass of: TXPO_0000635
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003671
database_cross_reference: EC:3.1.4.11
database_cross_reference: GO:0004629
has_exact_synonym: phospholipase C

PLC gamma
type: Class
subclass of: PLC (mol)
database_cross_reference: MeSH: D051966
has_exact_synonym: phospholipase C gamma

PLCbeta
type: Class
subclass of: PLC (mol)
has_exact_synonym: phospholipase C beta

PLD
type: Class
subclass of: TXPO_0000635
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003671
database_cross_reference: EC:3.1.4.4
database_cross_reference: GO:0004630
has_exact_synonym: phospholipase D

Ras family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003669
database_cross_reference: IPR:003577

Ras
type: Class
subclass of: Ras family
has_exact_synonym: Ras GTPase

KRAS (mol)
type: Class
subclass of: Ras
database_cross_reference: NCBI-Human-GeneID:3845
database_cross_reference: NCBI-Mouse-GeneID:16653
database_cross_reference: NCBI-Rat-GeneID:24525
has_exact_synonym: K-Ras
has_exact_synonym: Ki-ras

Axiom
annotated source: KRAS (mol)
annotated property: database_cross_reference
annotated target: NCBI-Human-GeneID:3845
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/3845

Axiom
annotated source: KRAS (mol)
annotated property: database_cross_reference
annotated target: NCBI-Mouse-GeneID:16653
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/16653

Axiom
annotated source: KRAS (mol)
annotated property: database_cross_reference
annotated target: NCBI-Rat-GeneID:24525
database_cross_reference: https://www.ncbi.nlm.nih.gov/gene/24525

R-Ras
type: Class
subclass of: Ras family
has_exact_synonym: related to Ras

Ral
type: Class
subclass of: Ras family
has_exact_synonym: Ras-like

Rap
type: Class
subclass of: Ras family
has_exact_synonym: Ras proximal

Rho family
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003669
database_cross_reference: IPR:003578

Rho
type: Class
subclass of: Rho family

Rac
type: Class
subclass of: Rho family

Rab
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003669
database_cross_reference: IPR:003579
has_exact_synonym: Ras genes from rat brain

Ran
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0000885
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003669
database_cross_reference: IPR:002041
has_exact_synonym: Ras-like nuclear protein
has_exact_synonym: TC4

Arf/Sar
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003669

protease
type: Class
subclass of: TXPO_0003663
database_cross_reference: EC:3.4.-.-
database_cross_reference: GO:0008233
has_exact_synonym: peptidase

caspase (family)
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: protease
database_cross_reference: GO:0030693

effector caspase
type: Class
subclass of: caspase (family)

signaling (initiator) caspase
type: Class
subclass of: caspase (family)

26S proteasome
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: protease
definition: The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins.
database_cross_reference: GO:0000502

Axiom
annotated source: 26S proteasome
annotated property: definition
annotated target: The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins.
database_cross_reference: PMID:10872471
database_cross_reference: PMID:9228274
database_cross_reference: PMID:9647729

G-alpha
type: Class
subclass of: molecule
subclass of: Restriction
  on property: has role
  some values from: TXPO_0003668
database_cross_reference: EC:3.6.5.1
has_exact_synonym: G-protein, alpha subunit
has_exact_synonym: Guanine nucleotide-binding protein, alpha subunit

G-alpha-s class
type: Class
subclass of: G-alpha

G-alpha-i class
type: Class
subclass of: G-alpha

G-alpha-i
type: Class
subclass of: G-alpha-i class

G-alpha-o
type: Class
subclass of: G-alpha-i class
definition: Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA.
has_alternative_id: IMR:0100371
has_alternative_id: IMR:0100372

Axiom
annotated source: G-alpha-o
annotated property: definition
annotated target: Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA.
database_cross_reference: PMID:9990023

G-alpha-t
type: Class
subclass of: G-alpha-i class
has_exact_synonym: transducin alpha

G-alpha-z
type: Class
subclass of: G-alpha-i class

G-alpha-q class
type: Class
subclass of: G-alpha

G-alpha-12/13 class
type: Class
subclass of: G-alpha

ubiquitin activating enzyme
type: Class
subclass of: TXPO_0003660
definition: Catalysis role of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
database_cross_reference: EC:6.2.1.45
database_cross_reference: IMR:0000327 (obsolete)
database_cross_reference: Wikipedia:Ubiquitin-activating_enzyme
has_exact_synonym: E1 ubiquitin-activating enzyme
has_exact_synonym: ubiquitin-activating enzyme (E1)
comment: related molecular function GO:0004839