---
name: idea-validation
description: |
  研究假說驗證與可行性評估框架。
  LOAD THIS SKILL WHEN: hypothesis、假說、PICO、feasibility、可行性、testable、可驗證、研究計畫評估、check feasibility
  CAPABILITIES: 純指令技能，不需要專屬 MCP tool。利用 LLM 推理能力 + 現有 tools (list_saved_references, search_local_references) 完成分析。
---

# 研究假說驗證與可行性評估技能

純指令技能。LLM 醫學知識 + `compare_with_literature`, `list_saved_references`, `search_local_references`, `validate_concept`。

觸發：hypothesis、假說、PICO、feasibility、可行性、testable、研究計畫評估

---

## Framework 1: Hypothesis Validation

### Step 1: PICO 分析

| Component        | 偵測重點                                      |
| ---------------- | --------------------------------------------- |
| **P**opulation   | patients, subjects, ICU, surgical...          |
| **I**ntervention | treatment, therapy, drug, procedure...        |
| **C**omparison   | versus, vs, placebo, standard, control...     |
| **O**utcome      | mortality, survival, recovery, score, rate... |

### Step 2: Testability

1. **Directional** — higher/lower/better/worse/reduce? ✅ vs 只有描述性 ❌
2. **Comparison** — significantly/compared/than? ✅ vs 缺基準 ❌
3. **Type** — Null (no difference) vs Alternative (有方向)
4. **Specificity** — <10 words 太模糊, 10-50 適當, >50 過複雜

### Step 3: Study Type Recommendation

| 假說特徵                  | 建議設計               |
| ------------------------- | ---------------------- |
| effect/efficacy/treatment | RCT or Cohort          |
| risk factor/association   | Cohort or Case-Control |
| prevalence/frequency      | Cross-Sectional        |

---

## Framework 2: Feasibility Assessment

### Sample Size Quick Check

| 類型       | 注意               |
| ---------- | ------------------ |
| N ≤ 10     | Case report/series |
| N < 30 RCT | Pilot or crossover |
| N ≥ 100    | 大多設計合理       |

### Timeline by Study Type

| 類型          | IRB             | 主要工作      | 分析寫作 |
| ------------- | --------------- | ------------- | -------- |
| RCT           | 2 mo            | 招募+收案 ÷3  | ÷4       |
| Retrospective | 1 mo            | 資料萃取 2 mo | ÷2       |
| SR            | 1 mo (protocol) | 搜尋+篩選 ÷3  | ÷3       |

### Feasibility Checklist (17 items, 5 categories)

| Category      | Critical Items             | High Items                                   |
| ------------- | -------------------------- | -------------------------------------------- |
| Data & Sample | 資料可及、樣本可達         | 納排標準                                     |
| Ethics        | IRB plan、informed consent | privacy                                      |
| Resources     | —                          | funding, timeline, team, equipment           |
| Methodology   | primary outcome            | stat plan, validated tools, confounders      |
| Publication   | —                          | target journal, reporting guideline, novelty |

**All Critical items must be ✅ before proceeding.**

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## 使用原則

1. PICO 分析用語意理解，非關鍵字匹配
2. 可行性評估寧可保守
3. 文獻比較用 `compare_with_literature` MCP tool