2025-11-24 The Emotion Response Ontology represents emotions as behavioral responses to a situation or event, or internal process which evokes positive feelings, negative feelings, or surprise (i.e., emotional experiences). Emotion Response Ontology 2026-06-22 editor preferred term The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred term example of usage A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> example of usage in branch An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet. GROUP:OBI OBI_0000277 in branch has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot has curation status definition The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obofoundry.org/obo/obi> editor note term editor Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> term editor alternative label A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like. OBO Operations committee PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> Consider re-defing to: An alternative name for a class or property which can mean the same thing as the preferred name (semantically equivalent, narrow, broad or related). alternative label definition source Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source has obsolescence reason Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. PERSON:Alan Ruttenberg PERSON:Melanie Courtot has obsolescence reason curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg curator note term tracker item the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ An IRI or similar locator for a request or discussion of an ontology term. Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg The 'tracker item' can associate a tracker with a specific ontology term. term tracker item ontology term requester The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition. Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg The 'term requester' can credit the person, organization or project who request the ontology term. ontology term requester is denotator type Relates an class defined in an ontology, to the type of it's denotator In OWL 2 add AnnotationPropertyRange('is denotator type' 'denotator type') Alan Ruttenberg is denotator type imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from expand expression to ObjectProperty: RO_0002104 Label: has plasma membrane part Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones Chris Mungall expand expression to expand assertion to ObjectProperty: RO??? Label: spatially disjoint from Annotations: expand_assertion_to "DisjointClasses: (http://purl.obolibrary.org/obo/BFO_0000051 some ?X) (http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom. Chris Mungall expand assertion to first order logic expression PERSON:Alan Ruttenberg first order logic expression antisymmetric property part_of antisymmetric property xsd:true Use boolean value xsd:true to indicate that the property is an antisymmetric property Alan Ruttenberg antisymmetric property OBO foundry unique label An alternative name for a class or property which is unique across the OBO Foundry. The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools . PERSON:Alan Ruttenberg PERSON:Bjoern Peters PERSON:Chris Mungall PERSON:Melanie Courtot GROUP:OBO Foundry <http://obofoundry.org/> OBO foundry unique label has ID digit count Ontology: <http://purl.obolibrary.org/obo/ro/idrange/> Annotations: 'has ID prefix': "http://purl.obolibrary.org/obo/RO_" 'has ID digit count' : 7, rdfs:label "RO id policy" 'has ID policy for': "RO" Relates an ontology used to record id policy to the number of digits in the URI. The URI is: the 'has ID prefix" annotation property value concatenated with an integer in the id range (left padded with "0"s to make this many digits) Person:Alan Ruttenberg has ID digit count has ID range allocated Datatype: idrange:1 Annotations: 'has ID range allocated to': "Chris Mungall" EquivalentTo: xsd:integer[> 2151 , <= 2300] Relates a datatype that encodes a range of integers to the name of the person or organization who can use those ids constructed in that range to define new terms Person:Alan Ruttenberg has ID range allocated to has ID policy for Ontology: <http://purl.obolibrary.org/obo/ro/idrange/> Annotations: 'has ID prefix': "http://purl.obolibrary.org/obo/RO_" 'has ID digit count' : 7, rdfs:label "RO id policy" 'has ID policy for': "RO" Relating an ontology used to record id policy to the ontology namespace whose policy it manages Person:Alan Ruttenberg has ID policy for has ID prefix Ontology: <http://purl.obolibrary.org/obo/ro/idrange/> Annotations: 'has ID prefix': "http://purl.obolibrary.org/obo/RO_" 'has ID digit count' : 7, rdfs:label "RO id policy" 'has ID policy for': "RO" Relates an ontology used to record id policy to a prefix concatenated with an integer in the id range (left padded with "0"s to make this many digits) to construct an ID for a term being created. Person:Alan Ruttenberg has ID prefix elucidation person:Alan Ruttenberg Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation has associated axiom(nl) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom associated with a term expressed using natural language has associated axiom(nl) has associated axiom(fol) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom expressed in first order logic using CLIF syntax has associated axiom(fol) is allocated id range Relates an ontology IRI to an (inclusive) range of IRIs in an OBO name space. The range is give as, e.g. "IAO_0020000-IAO_0020999" PERSON:Alan Ruttenberg Add as annotation triples in the granting ontology is allocated id range has ontology root term Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. Nicolas Matentzoglu has ontology root term may be identical to A annotation relationship between two terms in an ontology that may refer to the same (natural) type but where more evidence is required before terms are merged. David Osumi-Sutherland #40 VFB Edges asserting this should be annotated with to record evidence supporting the assertion and its provenance. may be identical to scheduled for obsoletion on or after Used when the class or object is scheduled for obsoletion/deprecation on or after a particular date. Chris Mungall, Jie Zheng https://github.com/geneontology/go-ontology/issues/15532 https://github.com/information-artifact-ontology/ontology-metadata/issues/32 GO ontology scheduled for obsoletion on or after has axiom id Person:Alan Ruttenberg Person:Alan Ruttenberg A URI that is intended to be unique label for an axiom used for tracking change to the ontology. For an axiom expressed in different languages, each expression is given the same URI has axiom label term replaced by Use on obsolete terms, relating the term to another term that can be used as a substitute Person:Alan Ruttenberg Person:Alan Ruttenberg Add as annotation triples in the granting ontology term replaced by This is an annotation used on an object property to indicate a logical characterstic beyond what is possible in OWL. OBO Operations call logical characteristic of object property 'part disjoint with' 'defined by construct' """ PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX : <http://example.org/ CONSTRUCT { [ a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?a ; owl:disjointWith [ a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?b ] ] } WHERE { ?a :part_disjoint_with ?b . } Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation. defined by construct CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation) A synonym type for describing abbreviations or initalisms 2023-03-03 abbreviation A synonym type for describing ambiguous synonyms 2023-03-03 ambiguous synonym A synonym type for describing dubious synonyms 2023-03-03 dubious synonym EFO:0006346 (severe cutaneous adverse reaction) has an exact synonym (scar), which is of the type OMO:0003003 (layperson synonym) A synonym type for describing layperson or colloquial synonyms 2023-03-03 layperson synonym CHEBI:23367 (molecular entity) has an exact synonym (molecular entities), which is of the type OMO:0003004 (plural form) A synonym type for describing pluralization synonyms 2023-03-03 plural form CHEBI:16189 (sulfate) has an exact synonym (sulphate), which is of the type OMO:0003005 (UK spelling synonym) A synonym type for describing UK spelling variants 2023-03-03 UK spelling synonym A synonym type for common misspellings 2023-03-03 misspelling A synonym type for misnomers, i.e., a synonym that is not technically correct but is commonly used anyway 2023-03-03 misnomer MAPT, the gene that encodes the Tau protein, has a previous name DDPAC. Note: in this case, the name type is more specifically the gene symbol. A synonym type for names that have been used as primary labels in the past. 2023-07-25 previous name The legal name for Harvard University (https://ror.org/03vek6s52) is President and Fellows of Harvard College A synonym type for the legal entity name 2023-07-27 legal name CHEBI:46195 has been assigned the english International Nonproproprietary Name (INN) "paracetamol". In some cases such as this one, the INN might be the same as the ontology's primary label The International Nonproprietary Name (INN) is a standardize name for a pharmaceutical drug or active ingredient issued by the World Health Organization (WHO) meant to address the issues with country- or language-specific brand names. These are issued in several languages, including English, Latin, French, Russian, Spanish, Arabic, and Chinese. 2023-09-30 International Nonproprietary Name nasopharynx (UBERON:0001728) has the latin name "pars nasalis pharyngis A synonym type for describing Latin term synonyms. 2023-10-12 latin term An alternative label for a class or property which has a more general meaning than the preferred name/primary label. https://github.com/information-artifact-ontology/ontology-metadata/issues/18 has broad synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/18 An alternative label for a class or property which has the exact same meaning than the preferred name/primary label. https://github.com/information-artifact-ontology/ontology-metadata/issues/20 has exact synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/20 An alternative label for a class or property which has a more specific meaning than the preferred name/primary label. https://github.com/information-artifact-ontology/ontology-metadata/issues/19 has narrow synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/19 An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct. https://github.com/information-artifact-ontology/ontology-metadata/issues/21 has related synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/21 is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole part_of BFO:0000050 external part_of part_of part of part of http://www.obofoundry.org/ro/#OBO_REL:part_of https://wiki.geneontology.org/Part_of has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part has_part BFO:0000051 external has_part has_part has part has part preceded by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by preceded by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. precedes inheres in this fragility is a characteristic of this vase this red color is a characteristic of this apple a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. inheres_in Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. characteristic of bearer of this apple is bearer of this red color this vase is bearer of this fragility Inverse of characteristic_of bearer_of is bearer of has characteristic participates in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation a relation between a continuant and a process, in which the continuant is somehow involved in the process participates_in participates in has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process has_participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. has function realized in capable of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. has function in capable of part of https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. consumes has input https://wiki.geneontology.org/Has_input p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. produces has output https://wiki.geneontology.org/Has_output q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. inheres in part of characteristic of part of A mereological relationship or a topological relationship mereotopologically related to a particular instances of akt-2 enables some instance of protein kinase activity c enables p iff c is capable of p and c acts to execute p. catalyzes executes has is catalyzing is executing enables https://wiki.geneontology.org/Enables A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. functionally related to inverse of enables enabled by https://wiki.geneontology.org/Enabled_by inverse of has input input of inverse of has output output of inverse of upstream of causally downstream of relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. causally related to relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. https://en.wikipedia.org/wiki/Causality p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. causally upstream of p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. influences (processual) affects causally upstream of or within inverse of causally upstream of or within causally downstream of or within A relationship between a material entity and a process where the material entity has some causal role that influences the process causal agent in process p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. causal relation between processes depends on A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. causal relation between material entity and a process process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] material entity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. material entity characteristic A behavioral response that includes overt action, cognitive response, verbal response, or physiological reaction in response to a situation or event, or internal process which evokes positive feelings, negative feelings, or surprise (i.e., emotional experiences). emotion process (EMRO) 2025-11-24T20:50:19Z emotion process A cognitive process during which an organism is aware of something either internal or external to itself. phenomenal cognitive experience (EMRO) 2025-11-24T20:52:17Z phenomenal cognitive experience A cognitive process during which an organism is aware of something either internal or external to itself. https://dictionary.apa.org/consciousness A phenomenal cognitive experience evaluated as pleasant or unpleasant. emotional experience (EMRO) 2025-11-24T20:52:39Z emotional experience A phenomenal cognitive experience evaluated as pleasant or unpleasant. https://dictionary.apa.org/feeling An emotion process that is a response that occurs more distally in time or physical space with regard to threatening stimuli. Anxiety typically involves worrying about experiencing threats that could or will be experienced in the future. anxiety process (EMRO) 2025-11-24T20:56:47Z anxiety process An emotion process that is an in-the-moment response to a perceived threat. Fear is typically associated with organized, robust visceral arousal. fear process (EMRO) 2025-11-24T20:57:08Z fear process A phenomenal cognitive experience produced by the parts of the nervous sysem involved in awareness of the external world (i.e., external stimulus) or changes to internal organs. A sensory experience does not necessarily entail the existence phenomenon experiences (e.g., hallucinations). sensory experience (EMRO) 2025-11-24T20:59:47Z sensory experience A phenomenal cognitive experience produced by the parts of the nervous sysem involved in awareness of the external world (i.e., external stimulus) or changes to internal organs. A sensory experience does not necessarily entail the existence phenomenon experiences (e.g., hallucinations). https://dictionary.apa.org/sensation A motor behavior that happens as a response to an emotion process. The motoric response includes muscle contractions that may move parts of the body or prevent the body from moving (e.g., freezing). motoric response to emotion (EMRO) 2025-11-24T21:02:42Z motoric response to emotion A psychophysiological process that is part of an emotion process. psychophysiological response to emotion (EMRO) 2025-11-24T21:10:13Z psychophysiological response to emotion Sweat screation that happens as a response to an emotion process. sweat secretion response to emotion (EMRO) 2025-11-24T22:22:47Z sweat secretion response to emotion An emotional valence which is inherently pleasant or attractive. positive emotional valence (EMRO) 2026-03-17T19:27:16Z Emotional valences exist on a continuum from pleasant to unpleasant, or from attractive to aversive. positive emotional valence An emotional valence which is inherently pleasant or attractive. https://dictionary.apa.org/emotional-valence Muscle contraction that happens as a response to an emotion process. muscle tension response to emotion (EMRO) 2025-11-24T22:36:17Z muscle tension response to emotion A heart process during which the rate at which the heart beats increases as a response to an emotion process. increased heart response to emotion (EMRO) 2025-11-24T22:39:24Z increased heart response to emotion A respiratory system process during which the rate at which an organism moves air in and out of its lungs increases as a response to an emotion process. increased breathing rate response to emotion (EMRO) 2025-11-24T22:44:09Z increased breathing rate response to emotion A cognitive process that happens as a response to an emotion process. cognitive response to emotion (EMRO) 2025-12-17T17:11:45Z cognitive response to emotion A cognitive process during which the nature and significance of a phenomenon or event is evaluated. cognitive appraisal process (EMRO) 2025-12-17T17:18:23Z cognitive appraisal process A transient loss of consciousness and postural tone that happens as a result of an emotion process. syncope response to emotion (EMRO) 2026-03-05T11:54:16Z fainting syncope fainting response to emotion vasovagal syncope syncope response to emotion A transient loss of consciousness and postural tone that happens as a result of an emotion process. Adapted from MeSH definition for syncope. See https://meshb.nlm.nih.gov/record/ui?ui=D013575 or http://purl.bioontology.org/ontology/SNOMEDCT/271594007. An emotional valence which is inherently unpleasant or aversive. negative emotional valence (EMRO) 2026-03-17T19:27:31Z Emotional valences exist on a continuum from pleasant to unpleasant, or from attractive to aversive. negative emotional valence An emotional valence which is inherently unpleasant or aversive. https://dictionary.apa.org/emotional-valence An emotional valence which is inherently neither pleasant nor unpleasant. neutral emotional valence (EMRO) 2026-03-17T19:29:48Z Emotional valences exist on a continuum from pleasant to unpleasant, or from attractive to aversive. Neutral emotional valences are in the center of this continuum. neutral emotional valence An emotional valence which is inherently neither pleasant nor unpleasant. https://dictionary.apa.org/emotional-valence Muscle contraction that happens as a response to a fear process. muscle tension response to fear (EMRO) 2026-03-05T21:16:30Z muscle tension response to fear psychophysiological response to emotion that is part of a fear process. psychophysiological response to fear (EMRO) 2026-03-05T21:20:49Z psychophysiological response to fear psychophysiological response to emotion that is part of an anxiety process. psychophysiological response to anxiety (EMRO) 2026-03-05T21:21:09Z psychophysiological response to anxiety Muscle contraction that happens as a response to an anxiety process. muscle tension response to anxiety (EMRO) 2026-03-05T21:24:05Z muscle tension response to anxiety A cognitive process that happens as a response to fear process. cognitive response to fear (EMRO) 2026-03-05T21:26:16Z cognitive response to fear A cognitive process that happens as a response to an anxiety process. cognitive response to anxiety (EMRO) 2026-03-05T21:26:25Z cognitive response to anxiety Sweat screation that happens as a response to a fear process. sweat secretion response to fear (EMRO) 2026-03-05T21:31:28Z sweat secretion response to fear Sweat screation that happens as a response to an anxiety process. sweat secretion response to anxiety (EMRO) 2026-03-05T21:31:36Z sweat secretion response to anxiety A heart process during which the rate at which the heart beats increases as a response to a fear process. increased heart response to fear (EMRO) 2026-03-05T21:32:52Z increased heart response to fear A heart process during which the rate at which the heart beats increases as a response to an anxiety process. increased heart response to anxiety (EMRO) 2026-03-05T21:33:04Z increased heart response to anxiety A respiratory system process during which the rate at which an organism moves air in and out of its lungs increases as a response to a fear process. increased breathing rate response to fear (EMRO) 2026-03-05T21:34:20Z increased breathing rate response to fear A respiratory system process during which the rate at which an organism moves air in and out of its lungs increases as a response to an anxiety process. increased breathing rate response to anxiety (EMRO) 2026-03-05T21:34:30Z increased breathing rate response to anxiety A transient loss of consciousness and postural tone that happens as a result of a fear process. syncope response to fear (EMRO) 2026-03-05T21:42:51Z syncope response to fear A transient loss of consciousness and postural tone that happens as a result of a fear process. Adapted from MeSH definition for syncope. See https://meshb.nlm.nih.gov/record/ui?ui=D013575 or http://purl.bioontology.org/ontology/SNOMEDCT/271594007. A transient loss of consciousness and postural tone that happens as a result of an anxiety process. syncope response to anxiety (EMRO) 2026-03-05T21:43:01Z syncope response to anxiety A transient loss of consciousness and postural tone that happens as a result of an anxiety process. Adapted from MeSH definition for syncope. See https://meshb.nlm.nih.gov/record/ui?ui=D013575 or http://purl.bioontology.org/ontology/SNOMEDCT/271594007. A motor behavior that happens as a response to a fear process. motoric response to fear (EMRO) 2026-03-05T22:03:57Z motoric response to fear A motor behavior that happens as a response to an anxiety process. motoric response to anxiety (EMRO) 2026-03-05T22:04:12Z motoric response to anxiety A process quality that characterizes the degree of positivity or negativity of an emotion process. emotional valence (EMRO) 2026-03-17T20:06:41Z the value associated with a stimulus as expressed on a continuum from pleasant to unpleasant or from attractive to aversive. In factor analysis and multidimensional scaling studies, emotional valence is one of two axes (or dimensions) on which an emotion can be located, the other axis being arousal (expressed as a continuum from high to low). For example, happiness is typically characterized by pleasant valence and relatively high arousal, whereas sadness or depression is typically characterized by unpleasant valence and relatively low arousal. hedonic tone According to cognitive appraisal theory, an individual's cognitive appraisal of a stimulus contributes to producing an emotion (with its corresponding emotional valence). emotional valence A process quality that characterizes the degree of positivity or negativity of an emotion process. https://dictionary.apa.org/emotional-valence A behavioral defense response in which an organism seeks to avoid an encounter with a potential external threat. avoidance behavior (EMRO) 2026-05-04T20:41:52Z avoidance behavior An emotional experience generated when events reflect on the worth or value of the self in one’s own or others’ eyes. self-conscious emotional experience (EMRO) 2026-05-04T20:44:41Z self-conscious emotional experience An emotional experience generated when events reflect on the worth or value of the self in one’s own or others’ eyes. https://dictionary.apa.org/self-conscious-emotion A self-conscious emotional experience in which a person feels awkward or flustered in other people’s company or because of the attention of others, as, for example, when being observed engaging in actions that are subject to mild disapproval from others. embarrassment (EMRO) 2026-05-04T20:47:27Z embarrassment A self-conscious emotional experience in which a person feels awkward or flustered in other people’s company or because of the attention of others, as, for example, when being observed engaging in actions that are subject to mild disapproval from others. https://dictionary.apa.org/embarrassment A highly unpleasant self-conscious emotional experience arising from the sense of there being something dishonorable, immodest, or indecorous in one’s own conduct or circumstances. shame (EMRO) 2026-05-04T20:55:14Z shame A highly unpleasant self-conscious emotional experience arising from the sense of there being something dishonorable, immodest, or indecorous in one’s own conduct or circumstances. https://dictionary.apa.org/shame A self-conscious emotional experience that occurs when a goal has been attained and one’s achievement has been recognized and approved by others. pride (EMRO) 2026-05-04T20:57:07Z pride A self-conscious emotional experience that occurs when a goal has been attained and one’s achievement has been recognized and approved by others. https://dictionary.apa.org/pride A self-conscious emotional experience characterized by a painful appraisal of having done (or thought) something that is wrong and often by a readiness to take action designed to undo or mitigate this wrong. guilt (EMRO) 2026-05-04T20:58:18Z guilt A self-conscious emotional experience characterized by a painful appraisal of having done (or thought) something that is wrong and often by a readiness to take action designed to undo or mitigate this wrong. https://dictionary.apa.org/guilt A process quality that characterizes a behavioral response to stimulus that is relatively stable, consistent, and enduring. personality triat characteristic (EMRO) 2026-06-05T19:34:58Z Personality triats are inferred from a pattern of behaviors, attitudes, feelings, and habits in the individual. personality trait personality trait characteristic personality trait A process quality that characterizes a behavioral response to stimulus that is relatively stable, consistent, and enduring. https://dictionary.apa.org/personality-trait An emotional experience characterized by the presence of pleasant affect (e.g., feelings of happiness) versus the absence of unpleasant affect (e.g., depressed mood). affective well-being (EMRO) 2026-06-08T16:15:01Z affective well-being affective well-being affective well-being An emotional experience characterized by the presence of pleasant affect (e.g., feelings of happiness) versus the absence of unpleasant affect (e.g., depressed mood). https://dictionary.apa.org/affective-well-being An emotion process during which negative feelings arise from the perception that one is not spending enough time alone. aloneliness process (EMRO) 2026-06-08T16:21:21Z aloneliness aloneliness process aloneliness A personality trait characteristic that is associated with anxiety and inhibition in social situations. https://dictionary.apa.org/shyness shyness triat characteristic (EMRO) 2026-06-08T16:26:11Z It typically involves three components: (a) global feelings of emotional arousal and specific physiological experiences (e.g., pounding heart, sweating, blushing); (b) acute public self-consciousness, self-deprecation, and worries about being evaluated negatively by others; and (c) observable behavior such as quietness, gaze aversion, and social withdrawal. shyness shyness trait characteristic shyness A personality trait characteristic that is associated with anxiety and inhibition in social situations. https://dictionary.apa.org/shyness A personality trait characteristic involving an orientation toward the internal private world of one’s self and one’s inner thoughts and feelings, rather than toward the outer world of people and things. introversion triat characteristic (EMRO) 2026-06-08T16:35:23Z introversion introversion trait characteristic introversion A personality trait characteristic involving an orientation toward the internal private world of one’s self and one’s inner thoughts and feelings, rather than toward the outer world of people and things. https://dictionary.apa.org/introversion The term anxious withdrawal (or anxious solitude) is better suited in a more specific domain ontology, such as PHASES. anxious withdrawal triat characteristic (EMRO) 2026-06-08T16:37:36Z anxious solitude obsolete anxious withdrawal trait characteristic true obsolete anxious withdrawal An emotion process involving a negative affective state, ranging from unhappiness and discontent to an extreme feeling of sadness, pessimism, and despondency, that interferes with daily life. depression process (EMRO) 2026-06-08T16:40:11Z depression depression process depression An emotion process involving a negative affective state, ranging from unhappiness and discontent to an extreme feeling of sadness, pessimism, and despondency, that interferes with daily life. https://dictionary.apa.org/depression A process quality characterizing the attitudes, values, and behaviors of a population or shared by a particular group within a society, such as a profession, social class, or age group. societal culture characteristic (EMRO) 2026-06-08T17:03:30Z The values, beliefs, language, rituals, traditions, and other behaviors that are passed from one generation to another within any social group. Broad definitions include any socially definable group with its own set of values, behaviors, and beliefs. Accordingly, cultural groups could include groups based on shared identities such as ethnicity. social culture societal culture characteristic culture A process quality characterizing the attitudes, values, and behaviors of a population or shared by a particular group within a society, such as a profession, social class, or age group. https://dictionary.apa.org/culture A cognitive process during which an individual produces or develops original work, theories, techniques, or thoughts. creativity (EMRO) 2026-06-08T17:06:26Z creativity creativity creativity A cognitive process during which an individual produces or develops original work, theories, techniques, or thoughts. https://dictionary.apa.org/creativity An emotion process that is a physiological or psychological response to internal or external stressors. stress process (EMRO) 2026-06-08T17:50:36Z Stress involves changes affecting nearly every system of the body, influencing how people feel and behave. stress stress process stress An emotion process that is a physiological or psychological response to internal or external stressors. https://dictionary.apa.org/stress An emotion process involving voluntary or involuntary absence of contact with others. social isolation process (EMRO) 2026-06-08T18:06:37Z Social isolation often produces abnormal behavioral and physiological changes in both humans and nonhuman animals. social isolation social isolation process social isolation An emotion process involving voluntary or involuntary absence of contact with others. https://dictionary.apa.org/social-isolation An emotion process of joy, gladness, satisfaction, and well-being. happiness (EMRO) 2026-06-08T20:14:47Z happiness happiness happiness An emotion process of joy, gladness, satisfaction, and well-being. https://dictionary.apa.org/happiness A personality trait characteristic involving restraint in engaging with the world combined with a tendency to scrutinize the environment for potential threats and to avoid or withdraw from unfamiliar situations or people. behavioral inhibition trait characteristic (EMRO) 2026-06-08T20:20:37Z behavioral inhibition behavioural inhibition behavioral inhibition trait characteristic behavioral inhibition A personality trait characteristic involving restraint in engaging with the world combined with a tendency to scrutinize the environment for potential threats and to avoid or withdraw from unfamiliar situations or people. https://dictionary.apa.org/behavioral-inhibition An emotion process involving the removal of oneself from familiar and unfamiliar peers. social withdrawal process (EMRO) 2026-06-08T20:47:51Z social withdrawal social withdrawal process social withdrawal An emotion process involving the removal of oneself from familiar and unfamiliar peers. Rubin, K. H., Coplan, R. J., & Bowker, J. C. (2009). Social withdrawal in childhood. Annual Review of Psychology, 60(1), 141–171. An emotion process involving affective and cognitive discomfort or uneasiness that arises from being or perceiving oneself to be alone or otherwise solitary. loneliness process (EMRO) 2026-06-08T21:04:33Z loneliness loneliness process loneliness An emotion process involving affective and cognitive discomfort or uneasiness that arises from being or perceiving oneself to be alone or otherwise solitary. https://dictionary.apa.org/loneliness A behavioral response seeking to protect an organism from an perceived external threat to that organism. behavioural defense response biological_process GO:0002209 behavioral defense response A behavioral response seeking to protect an organism from an perceived external threat to that organism. GOC:add GO_REF:0000022 A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. organ system process biological_process GO:0003008 system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. GOC:mtg_cardio An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. biological_process muscle physiological process GO:0003012 muscle system process An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. GOC:mtg_cardio An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. Wikipedia:Circulatory_system biological_process GO:0003013 circulatory system process An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. GOC:mtg_cardio A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. biological_process cardiac process GO:0003015 heart process A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. GOC:mtg_cardio A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. GO:0010802 respiratory gaseous exchange biological_process GO:0003016 respiratory system process A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. GOC:dph GOC:mtg_cardio GOC:tb The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. https://github.com/geneontology/go-ontology/issues/20292 jl 2012-12-13T16:25:32Z GO:0015457 GO:0015460 GO:0044765 Reactome:R-HSA-382551 biological_process single-organism transport GO:0006810 Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. GOC:dos GOC:dph GOC:jl GOC:mah Reactome:R-HSA-382551 Transport of small molecules A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Reactome:R-HSA-445355 Wikipedia:Muscle_contraction biological_process GO:0006936 muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. GOC:ef GOC:mtg_muscle ISBN:0198506732 Reactome:R-HSA-445355 Smooth Muscle Contraction The controlled release of a fluid by a cell or tissue in an animal. biological_process GO:0007589 body fluid secretion The controlled release of a fluid by a cell or tissue in an animal. GOC:ai GOC:dph GOC:mah GOC:tb The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. jl 2012-09-20T14:06:08Z GO:0023032 GO:0044708 GO:0044709 Wikipedia:Behavior behavioral response to stimulus behaviour behavioural response to stimulus biological_process single-organism behavior GO:0007610 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). behavior behavioral response to stimulus The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. GOC:ems GOC:jl ISBN:0395448956 PMID:20160973 A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. https://github.com/geneontology/go-ontology/issues/24968 jl 2012-09-19T15:05:24Z GO:0000004 GO:0007582 GO:0044699 Wikipedia:Biological_process biological process physiological process biological_process single organism process single-organism process GO:0008150 Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. GOC:pdt Any biological process, occurring at the level of a multicellular organism, pertinent to its function. https://github.com/geneontology/go-ontology/issues/27189 jl 2012-09-19T16:07:47Z GO:0044707 GO:0050874 organismal physiological process biological_process single-multicellular organism process GO:0032501 Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. GOC:curators GOC:dph GOC:isa_complete GOC:tb The controlled release of a substance by a tissue. tissue secretion biological_process expulsion of gland contents GO:0032941 secretion by tissue The controlled release of a substance by a tissue. GOC:mah expulsion of gland contents GOC:mah Self-propelled movement of a cell or organism from one location to another. biological_process GO:0040011 locomotion Self-propelled movement of a cell or organism from one location to another. GOC:dgh The controlled release of a substance by a cell or a tissue. biological_process GO:0046903 secretion The controlled release of a substance by a cell or a tissue. GOC:ai An organ system process carried out by any of the organs or tissues of the neurological system. https://github.com/geneontology/go-ontology/issues/13824 neurological system process neurophysiological process biological_process pan-neural process GO:0050877 nervous system process An organ system process carried out by any of the organs or tissues of the neurological system. GOC:ai GOC:mtg_cardio Any process that modulates the levels of body fluids. biological_process GO:0050878 regulation of body fluid levels Any process that modulates the levels of body fluids. GOC:ai GOC:dph GOC:tb The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. Wikipedia:Cognition biological_process GO:0050890 cognition cognitive process The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. ISBN:0721619908 Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. https://github.com/geneontology/go-ontology/issues/27052 jl 2013-12-18T13:51:04Z GO:1902578 establishment and maintenance of localization establishment and maintenance of position localisation establishment and maintenance of cellular component location establishment and maintenance of substance location establishment and maintenance of substrate location biological_process single organism localization single-organism localization GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. GOC:ai GOC:dos localisation GOC:mah single organism localization GOC:TermGenie Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. https://github.com/geneontology/go-ontology/issues/24200 establishment of localisation biological_process GO:0051234 establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. GOC:ai GOC:dos establishment of localisation GOC:mah The specific neuromuscular movement of a single organism in response to external or internal stimuli. dph 2015-11-09T12:43:11Z biological_process GO:0061744 motor behavior The specific neuromuscular movement of a single organism in response to external or internal stimuli. GOC:PARL GOC:bf PMID:25318560 Any process that modulates a measurable attribute of any biological process, quality or function. regulation biological_process GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function. GOC:dph GOC:isa_complete GOC:mah GOC:pr GOC:vw Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. https://github.com/geneontology/go-ontology/issues/30599 regulation of biological attribute regulation of biological characteristic biological_process GO:0065008 regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. GOC:dph GOC:isa_complete GOC:mah GOC:pr GOC:vw The regulated release of sweat from the sweat glands. https://github.com/geneontology/go-ontology/issues/30274. rynl 2025-05-19T20:55:14Z perspiration perspiring sweating biological_process GO:0160269 sweat secretion The regulated release of sweat from the sweat glands. PMID:1778649 population PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population. a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area. PERSON: Philippe Rocca-Serra adapted from Oxford English Dictionnary population A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities PATO:0000072 quality PATO:0000001 quality A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities PATOC:GVG A quality which inheres in an process. PATO:0001239 PATO:0001240 quality of a process quality of occurrent quality of process relational quality of occurrent quality PATO:0001236 See comments of relational quality of a physical entity. process quality A quality which inheres in an process. PATOC:GVG A portion of organism substance that is produced by exocrine glands. BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions UBERON:0006540 secretion AEO:0001005 BTO:0002977 BTO:0002979 EMAPA:36535 FMA:9675 MA:0002504 MESH:D012634 NCIT:C34062 UMLS:C1516992 galen:Secretion bodily secretion exocrine gland fluid/secretion secreted substance exocrine gland fluid exocrine gland fluid or secretion exocrine gland secretion external secretion UBERON:0000456 secretion of exocrine gland A portion of organism substance that is produced by exocrine glands. http://orcid.org/0000-0002-6601-2165 BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions BTO secretion FMA:9675 UMLS:C1516992 ncithesaurus:Exocrine_Gland_Fluid_or_Secretion bodily secretion MESH:D012634 exocrine gland fluid/secretion MA:0002504 external secretion BTO:0002977 Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. AAO:0010839 AEO:0000004 BILA:0000004 CALOHA:TS-2101 CARO:0000004 EHDAA2:0003004 EMAPA:35178 FBbt:00007019 FMA:9669 HAO:0000004 MA:0002450 NCIT:C13236 SPD:0000008 TAO:0001487 TGMA:0001824 VHOG:0001726 XAO:0004001 ZFA:0001487 galen:BodySubstance body fluid or substance body substance organism substance portion of body substance portion of organism substance UBERON:0000463 organism substance Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. http://orcid.org/0000-0001-9114-8737 FBbt:00007019 body fluid or substance MA:0002450 body substance FMA:9669 organism substance CARO:0000004 portion of body substance FMA:9669 portion of organism substance ZFA:0001487 Anatomical entity that has mass. AAO:0010264 AEO:0000006 BILA:0000006 CARO:0000006 EHDAA2:0003006 FBbt:00007016 FMA:67165 HAO:0000006 TAO:0001836 TGMA:0001826 VHOG:0001721 UBERON:0000465 material anatomical entity Anatomical entity that has mass. http://orcid.org/0000-0001-9114-8737 FBbt:00007016 Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. AAO:0010841 AEO:0000000 BFO:0000004 BILA:0000000 BIRNLEX:6 CARO:0000000 EHDAA2:0002229 FBbt:10000000 FMA:62955 HAO:0000000 MA:0000001 NCIT:C12219 TAO:0100000 TGMA:0001822 UMLS:C1515976 WBbt:0000100 XAO:0000000 ZFA:0100000 UBERON:0001062 anatomical entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. FMA:62955 http://orcid.org/0000-0001-9114-8737 FBbt:10000000 UMLS:C1515976 ncithesaurus:Anatomic_Structure_System_or_Substance Secretion produced by a sweat gland. BTO:0001254 ENVO:02000025 FMA:12275 GAID:1172 MA:0002539 MESH:D013542 NCIT:C13280 UMLS:C0038984 Wikipedia:Sweat skin exudate UBERON:0001089 sweat Secretion produced by a sweat gland. FMA:12275 UMLS:C0038984 ncithesaurus:Sweat skin exudate BTO:0001254 Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. fluid BIRNLEX:20 EMAPA:37441 FMA:280556 GAID:266 MESH:D001826 Wikipedia:Body_fluid galen:BodyFluid body fluid UBERON:0006314 bodily fluid Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. MESH:A12.207 Wikipedia:Body_fluid EMAPA:37441 MA:th body fluid GAID:266 2026-03-24T21:31:17Z obsolete class example to be eventually removed example to be eventually removed failed exploratory term The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job Person:Alan Ruttenberg failed exploratory term metadata complete Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. metadata complete organizational term Term created to ease viewing/sort terms for development purpose, and will not be included in a release organizational term ready for release Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." ready for release metadata incomplete Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. metadata incomplete uncurated Nothing done yet beyond assigning a unique class ID and proposing a preferred term. uncurated pending final vetting All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. pending final vetting placeholder removed placeholder removed terms merged An editor note should explain what were the merged terms and the reason for the merge. terms merged term imported This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. term imported term split This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. term split universal Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. Alan Ruttenberg A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf universal defined class A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. Alan Ruttenberg defined class named class expression A named class expression is a logical expression that is given a name. The name can be used in place of the expression. named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions Alan Ruttenberg named class expression to be replaced with external ontology term Terms with this status should eventually replaced with a term from another ontology. Alan Ruttenberg group:OBI to be replaced with external ontology term requires discussion A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. Alan Ruttenberg group:OBI requires discussion The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not. This obsolesence reason should be used conservatively. Typical valid examples are: un-necessary grouping classes in disease ontologies, a phenotype term added on the assumption it was a disease. https://github.com/information-artifact-ontology/ontology-metadata/issues/77 https://orcid.org/0000-0001-5208-3432 out of scope The term was added to the ontology on the assumption it was a valid domain entity, but it turns out the entity does not exist in reality. This obsolesence reason should be used conservatively. For example: Obsoleting class that describes a breed of cow based on a record in an existing database, that was later retracted as faulty (breed does not exist). Do not use this term to obsolete a historic concept (that was once valid, but not anymore). https://github.com/information-artifact-ontology/ontology-metadata/issues/136 https://orcid.org/0000-0002-4142-7153 domain entity does not exist Damayanthi Jesudas Bill Duncan Alexander D. Diehl Daniel W. McNeil Finn Wilson Ram A.N.R. Challa