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MOSAIC: A modular single-molecule analysis interface
==================================================================

MOSAIC is a single molecule analysis toolbox that automatically decodes multi-state nanopore data. By modeling the nanopore system with an equivalent circuit, MOSAIC leverages the transient response of a molecule entering the channel to quantify pore-molecule interactions. In contrast to existing techniques such as ionic current thresholding or Viterbi decoding, this technique allows the estimation of short-lived transient events that are otherwise not analyzed.

Nanometer-scale pores have demonstrated potential use in biotechnology applications, including DNA sequencing, single-molecule force spectroscopy, and single-molecule mass spectrometry. The data modeling and analysis methods implemented in MOSAIC allow for dramatic improvements in the quantification of molecular interactions with the channel in each of these applications.

**If you use MOSAIC in your work, please cite both papers below:**

1. `Analytical Chemistry 2016, (88) pp. 11900–11907  <http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03725>`_
2. `ACS Nano 2014, (8) pp. 1547–1553.  <http://pubs.acs.org/doi/abs/10.1021/nn405761y>`_

Installation
==================================================================

Please refer to the `Installation <https://pages.nist.gov/mosaic/html/doc/GettingStarted.html>`_ section of the MOSAIC documentation for details on installation.

Documentation
==================================================================

A PDF version of the MOSAIC documentation can be downloaded `here <https://github.com/usnistgov/mosaic/raw/nist-pages/latex/MOSAIC.pdf>`_.

Getting Help
==================================================================

If you need help or have questions, please join our mailing list.

To subscribe:

	Visit `https://groups.google.com/a/list.nist.gov/group/mosaic/ <https://groups.google.com/a/list.nist.gov/group/mosaic/>`_.

To unsubscribe:

	Email `mosaic+unsubscribe@list.nist.gov <mailto:mosaic+unsubscribe@list.nist.gov>`_.

Once subscribed, you can send messages by emailing `mosaic@list.nist.gov <mailto:mosaic@list.nist.gov>`_.

Reporting Problems
==================================================================

Report problems using our `issue tracker <https://github.com/usnistgov/mosaic/issues>`_ on Github.

What's New?
==================================================================

Read the `Change Log <CHANGELOG.rst>`_