# Links concentrations of related metabolites in the model to keep a constant proportion. # The lead should have a mechanism for a variable concentration and linked should otherwise # be static. "Lead metabolite" "Linked metabolite" "_notes" "MET[c]" "S-ADENOSYLMETHIONINE[c]" "Met is variable through amino acid supply in translation, SAM regulates Met synthesis through MetJ binding so low Met should lead to increased synthesis through SAM"