Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP100 CPTAC Assay Portal] b28 (5-L-Glutamyl)-L-amino acid RX

14988435 PubMed Glutathione metabolism and its implications for health. J Nutr 2004 Wu G Fang YZ Yang S Lupton JR Turner ND glutathione metabolic pathway PW:0000134 Pathway Ontology