Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]] This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP197&oldid=21093 WP197(r21093)] with a 88% conversion rate. cb0 af4 c95 e3e f61 b27 bb3 NAD(P) dependent steroid dehydrogenase-like cholesterol biosynthetic pathway PW:0000454 Pathway Ontology 8552601 PubMed Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A 1996 Bard M Bruner DA Pierson CA Lees ND Biermann B Frye L Koegel C Barbuch R 11969204 PubMed Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun 2002 Gaylor JL 8663358 PubMed Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem 1996 Li L Kaplan J 10369263 PubMed The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet 1999 Liu XY Dangel AW Kelley RI Zhao W Denny P Botcherby M Cattanach B Peters J Hunsicker PR Mallon AM Strivens MA Bate R Miller W Rhodes M Brown SD Herman GE 12837764 PubMed Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 2003 Ohashi M Mizushima N Kabeya Y Yoshimori T 8407863 PubMed Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem 1993 Sagami H Korenaga T Ogura K 9498553 PubMed Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA. J Biochem 1997 Noshiro M Aoyama Y Kawamoto T Gotoh O Horiuchi T Yoshida Y