Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia] This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP430_r78268 WP430(78268)] with a 90.0% conversion rate. c3a HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19 HomologyConvert: Multiple homologues found: En:ENSBTAG00000020558;En:ENSBTAG00000020558; HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547 a6b hepatocyte CL:0000182 Cell Ontology cardiovascular system disease DOID:1287 Human Disease Ontology statin drug pathway PW:0000724 Pathway Ontology 10770267 PubMed Direct effects of statins on cells primarily involved in atherosclerosis. Hypertens Res 2000 Chen H Ikeda U Shimpo M Shimada K 9106493 PubMed Microsomal triglyceride transfer protein. Biochim Biophys Acta 1997 Wetterau JR Lin MC Jamil H