Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP430_r78268 WP430(78268)] with a 90.0% conversion rate. c3a HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19 HomologyConvert: Multiple homologues found: En:ENSBTAG00000020558;En:ENSBTAG00000020558; HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547 a6b cardiovascular system disease DOID:1287 Disease 10770267 PubMed Direct effects of statins on cells primarily involved in atherosclerosis. Hypertens Res 2000 Chen H Ikeda U Shimpo M Shimada K statin drug pathway PW:0000724 Pathway Ontology CL:0000584 Cell Type 9106493 PubMed Microsomal triglyceride transfer protein. Biochim Biophys Acta 1997 Wetterau JR Lin MC Jamil H hepatocyte CL:0000182 Cell Type