In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]] Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP405_r73594 WP405(73594)] with a 97.0% conversion rate. c7b bc954 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6908 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2959 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6877 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6878 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6879 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6880 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6884 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2960 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2963 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2961 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1022 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2965 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2966 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2968 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2071 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2068 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84172 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55703 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5435 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5434 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5440 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:171568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51728 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25885 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5438 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5437 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5431 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4331 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51082 RNA polymerase III transcription initiation pathway PW:0001575 Pathway Ontology RNA polymerase II transcription initiation pathway PW:0001274 Pathway Ontology RNA polymerase I transcription initiation pathway PW:0001570 Pathway Ontology 11040209 PubMed Orchestrated response: a symphony of transcription factors for gene control. Genes Dev 2000 Lemon B Tjian R 9585500 PubMed Regulation of gene expression by TBP-associated proteins. Genes Dev 1998 Lee TI Young RA