An electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set of mediating biochemical reactions. These H+ ions are used to produce adenosine triphosphate (ATP), the main energy intermediate in living organisms, as they move back across the membrane.
In mitochondria, it is the conversion of oxygen to water, NADH to NAD+ and succinate to fumarate that drives the transfer of H+ ions.
Source: Wikipedia ([[wikipedia:Electron_transport_chain]])
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP111 CPTAC Assay Portal]dc1e55ac6electron transport chain pathwayPW:0000034Pathway Ontologyclassic metabolic pathwayPW:0000002Pathway Ontology30030361PubMedAssembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.Essays Biochem2018Signes AFernandez-Vizarra E22902835PubMedNDUFA4 is a subunit of complex IV of the mammalian electron transport chain.Cell Metab2012Balsa EMarco RPerales-Clemente ESzklarczyk RCalvo ELandázuri MOEnrĂquez JA23746447PubMedNDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease.Cell Rep2013Pitceathly RDRahman SWedatilake YPolke JMCirak SFoley ARSailer AHurles MEStalker JHargreaves IWoodward CESweeney MGMuntoni FHoulden HTaanman JWHanna MG