This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP117 CPTAC Assay Portal]
a3b
d0d
G protein mediated signaling pathway
PW:0000125
Pathway Ontology
11836223
PubMed
Classifying G-protein coupled receptors with support vector machines.
Bioinformatics
2002
Karchin R
Karplus K
Haussler D
9399852
PubMed
GPCRDB: an information system for G protein-coupled receptors.
Nucleic Acids Res
1998
Horn F
Weare J
Beukers MW
Hörsch S
Bairoch A
Chen W
Edvardsen O
Campagne F
Vriend G