The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides. This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP581&oldid=22574 WP581(r22574)] with a 100% conversion rate. e8b bb4 Not sure if complex consists of both A and B isoforms [thomas-081110] erythropoietin signaling pathway PW:0000987 Pathway Ontology 10334664 PubMed The molecular biology of erythropoietin. Nephrol Dial Transplant 1999 Lacombe C Mayeux P 9371269 PubMed The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol 1994 Zhu Y D'Andrea AD