Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&oldid=28124 WP619(r28124)] with a 94% conversion rate. f74 type II interferon signaling pathway PW:0000896 Pathway Ontology 18433497 PubMed A logic-based diagram of signalling pathways central to macrophage activation. BMC Syst Biol 2008 Raza S Robertson KA Lacaze PA Page D Enright AJ Ghazal P Freeman TC