Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&oldid=28124 WP619(r28124)] with a 94% conversion rate.f74type II interferon signaling pathwayPW:0000896Pathway Ontology18433497PubMedA logic-based diagram of signalling pathways central to macrophage activation.BMC Syst Biol2008Raza SRobertson KALacaze PAPage DEnright AJGhazal PFreeman TC