Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today. This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP254_r95107 WP254 (r95107)] with a 88.0% conversion rate. No homologues found for original id L:5366 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:842 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4193 No homologues found for original id L:578 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7187 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3659 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:355 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:329 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:56616 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3002 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:27242 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:572 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4792 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:834 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8737 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3660 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4793 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4049 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:837 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3664 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:836 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5551 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7132 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3480 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5970 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1147 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:581 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:317 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7133 No homologues found for original id L:843 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:330 No homologues found for original id L:637 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8718 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7185 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3663 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1676 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:54205 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4793 No homologues found for original id L:27113 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3661 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:835 No homologues found for original id L:8739 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7161 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9169 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:840 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7124 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3481 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8738 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8517 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:666 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8837 No homologues found for original id L:599 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5295 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8717 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:332 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3479 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8795 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:665 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1677 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8717 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:596 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7132 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3665 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5970 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:598 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3662 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4794 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7157 c76 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8737 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1029 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:841 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:331 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:572 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4792 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:356 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8743 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4794 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3070 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8772 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4170 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:839 No homologues found for original id L:10018 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8626 cff fd8b3 c9a regulatory pathway PW:0000004 Pathway Ontology 10618704 PubMed Regulation of p53 in response to DNA damage. Oncogene 1999 Lakin ND Jackson SP 19079265 PubMed miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 2009 Park SY Lee JH Ha M Nam JW Kim VN 17404574 PubMed mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007 Mott JL Kobayashi S Bronk SF Gores GJ 17914240 PubMed The p53-MDM2 network: from oscillations to apoptosis. J Biosci 2007 Bose I Ghosh B