The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al). This pathway has been updated with information from Lipidmaps>Sphingolipids [https://lipidmaps.org/resources/pathways/vanted.php]. Metabolites and proteins from this pathway are coloured orange and have a rounded rectangle shape (where an oval shape indicates that the node only occures in the LipidMaps pathway). Reactions occurring in the lipidmaps pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LipidMaps pathway). c48 c88 2.3.1.24 (dihydro)ceramide synthases Where does this abbreviation stand for? dihydrosterigmatocystin?! 2.3.1.50 protein phosphatase 1 (PP1) protein-serine/threonine phosphatase Ceramidase 1.1.1.102 C16 Dihydroceramide-1-Phosphate C16 DihydroLactosylceramide 3-ketodihydrosphingosine reductase (dihydro)ceramide synthases. ASAH3 is old name of ACER1 dihydrosphingomyelin (dihydro)ceramide synthases (dihydro)ceramide synthases. ASAH3 is old name of ACER1 C16 Dihydro-Glucosyl- ceramide sphinganine-1-phosphate sphingosine-1-phosphate (S1P) lyase C16 Dihydro-GalactoCerebroside 4.1.2.27 2.7.8.3 Glucosylceramide 2.7.8.3 2.7.1.138 protein phosphatase 2A (PP2A) 2.3.1.24 protein phosphatase 1 (PP1) Glucosylceramidase protein phosphatase 2A (PP2A) UGT8 / CGT glucosylceramide synthase (GCS) UGT8 / CGT glucosylceramide synthase (GCS) Sphingomyelin synthase 2 Sphingomyelin synthase 1 sphinganine-1-phosphate f3e f3e sphingolipid metabolic pathway PW:0000197 Pathway Ontology 19029065 PubMed Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. J Lipid Res 2009 Merrill AH Jr Stokes TH Momin A Park H Portz BJ Kelly S Wang E Sullards MC Wang MD 17928229 PubMed (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology. Trends Biochem Sci 2007 Merrill AH Jr Wang MD Park M Sullards MC 18216770 PubMed Principles of bioactive lipid signalling: lessons from sphingolipids. Nature reviews Molecular cell biology 2008 Hannun YA Obeid LM