TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1471 CPTAC Assay Portal] b27 a76 fbe f9c cda cda cda cda b36 insulin signaling pathway PW:0000143 Pathway Ontology 25310982 PubMed mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells. Cell Rep 2014 Norrmén C Figlia G Lebrun-Julien F Pereira JA Trötzmüller M Köfeler HC Rantanen V Wessig C van Deijk AL Smit AB Verheijen MH Rüegg MA Hall MN Suter U 16516475 PubMed Complexity of the TOR signaling network. Trends Cell Biol 2006 Inoki K Guan KL 17041621 PubMed Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 2006 Corradetti MN Guan KL mTOR signaling pathway PW:0000180 Pathway Ontology 19143648 PubMed Rag proteins regulate amino-acid-induced mTORC1 signalling. Biochem Soc Trans 2009 Sancak Y Sabatini DM 16469695 PubMed TOR signaling in growth and metabolism. Cell 2006 Wullschleger S Loewith R Hall MN AMPK signaling pathway PW:0000542 Pathway Ontology 17680028 PubMed Expanding mTOR signaling. Cell Res 2007 Yang Q Guan KL