TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response.
TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1471 CPTAC Assay Portal]b27a76fbef9ccdacdacdacdab36insulin signaling pathwayPW:0000143Pathway Ontology25310982PubMedmTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.Cell Rep2014Norrmén CFiglia GLebrun-Julien FPereira JATrötzmüller MKöfeler HCRantanen VWessig Cvan Deijk ALSmit ABVerheijen MHRüegg MAHall MNSuter U16516475PubMedComplexity of the TOR signaling network.Trends Cell Biol2006Inoki KGuan KL17041621PubMedUpstream of the mammalian target of rapamycin: do all roads pass through mTOR?Oncogene2006Corradetti MNGuan KLmTOR signaling pathwayPW:0000180Pathway Ontology19143648PubMedRag proteins regulate amino-acid-induced mTORC1 signalling.Biochem Soc Trans2009Sancak YSabatini DM16469695PubMedTOR signaling in growth and metabolism.Cell2006Wullschleger SLoewith RHall MNAMPK signaling pathwayPW:0000542Pathway Ontology17680028PubMedExpanding mTOR signaling.Cell Res2007Yang QGuan KL