This is the first of two pathways which deals with the DNA damage response. It comprises two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The two central genes can both be divides into their most important genes. For the ATM pathway these are TP53 and CHEK2, while CHEK1 is most important for the ATR pathway. The goal of this first pathway is to provide an overview of the most important gene products, processes and changes in cell condition elicited by the DNA damage response while keeping it clear and understandable. Also some microRNAs are implemented to visualize the possible effects they can induce. By doing so a better understanding of the role microRNA play in the DNA damage response might arise. All processes take place in the cytoplasm, except when mentioned differently. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1530 CPTAC Assay Portal]. efb bc7 c56 e48 d50 b66 ac5 b4f a1b df4 c56 e48 d50 b66 ac5 b4f a1b df4 e6f e6f a35 d5f d5f c48 d5f e6f a35 d5f e6f d5f e6f a35 e6f a35 e48 dab af9 c04 da1 e6f a35 efb d5f d5f bf4 c56 e48 d50 b66 ac5 b4f a1b df4 bf4 d5f d5f c48 c48 c56 e48 d50 b66 ac5 b4f a1b df4 d5f bf4 c56 e48 d50 b66 ac5 b4f a1b df4 d5f d5f e6f a35 efb c48 d5f c56 e48 d50 b66 ac5 b4f a1b df4 c56 e48 d50 b66 ac5 b4f a1b df4 e10 f43 dd5 d84 fc9 a53 b4d f7f ffc aa6 d84 aa7 a9d d84 f7f a9d aa6 fe5 ed5 a4b a9d ef4 f7f f95 aa6 a6a a9d fb9 dd5 f95 d7c fc9 c11 a41 f7f b08 dd0 d43 f7f f4e 19141645 PubMed MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009 Crosby ME Kulshreshtha R Ivan M Glazer PM 20406979 PubMed The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. 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