MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1545 CPTAC Assay Portal].
This pathway show all microRNA gene cluster involed in the wikipathway pathway "DNA damage response (Homo sapiens)". More info can be found there.
b2c
f0d
c1b
e84
c1b
eb7
c49
a81
b86
cab
d9d
d8f
cab
c49
d9d
dba
b86
c49
d19
b86
d8c
d91
d9d
d19
fff
d9d
a64
d9d
b9d
d32
ebc
a58
c49
cab
dfa
fd9
e95
f9c
eb7
a58
ed2
c1b
ee6
fd7
b86
edd
f46
d8c
d91
c49
DNA repair pathway
PW:0000099
Pathway Ontology
miRNA pathway
PW:0000808
Pathway Ontology
18695042
PubMed
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
J Cell Biol
2008
Yu Z
Wang C
Wang M
Li Z
Casimiro MC
Liu M
Wu K
Whittle J
Ju X
Hyslop T
McCue P
Pestell RG
18538733
PubMed
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
Cancer Cell
2008
Bueno MJ
Pérez de Castro I
Gómez de Cedrón M
Santos J
Calin GA
Cigudosa JC
Croce CM
Fernández-Piqueras J
Malumbres M
20086245
PubMed
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.
Blood
2010
Zhao JJ
Lin J
Lwin T
Yang H
Guo J
Kong W
Dessureault S
Moscinski LC
Rezania D
Dalton WS
Sotomayor E
Tao J
Cheng JQ
19258499
PubMed
miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.
Cancer Res
2009
Pigazzi M
Manara E
Baron E
Basso G
19141645
PubMed
MicroRNA regulation of DNA repair gene expression in hypoxic stress.
Cancer Res
2009
Crosby ME
Kulshreshtha R
Ivan M
Glazer PM
18066065
PubMed
Widespread microRNA repression by Myc contributes to tumorigenesis.
Nat Genet
2008
Chang TC
Yu D
Lee YS
Wentzel EA
Arking DE
West KM
Dang CV
Thomas-Tikhonenko A
Mendell JT
19377482
PubMed
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.
Nat Struct Mol Biol
2009
Lal A
Pan Y
Navarro F
Dykxhoorn DM
Moreau L
Meire E
Bentwich Z
Lieberman J
Chowdhury D
19833767
PubMed
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
Genes Dev
2009
Yang X
Feng M
Jiang X
Wu Z
Li Z
Aau M
Yu Q
20404092
PubMed
Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.
Mol Cell Biol
2010
Bueno MJ
Gómez de Cedrón M
Laresgoiti U
Fernández-Piqueras J
Zubiaga AM
Malumbres M
18701644
PubMed
miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.
Nucleic Acids Res
2008
Liu Q
Fu H
Sun F
Zhang H
Tie Y
Zhu J
Xing R
Sun Z
Zheng X
19034270
PubMed
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.
Mol Syst Biol
2008
Brosh R
Shalgi R
Liran A
Landan G
Korotayev K
Nguyen GH
Enerly E
Johnsen H
Buganim Y
Solomon H
Goldstein I
Madar S
Goldfinger N
Børresen-Dale AL
Ginsberg D
Harris CC
Pilpel Y
Oren M
Rotter V
19597470
PubMed
MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.
Oncogene
2009
Lee KH
Chen YL
Yeh SD
Hsiao M
Lin JT
Goan YG
Lu PJ
19202062
PubMed
p53 represses c-Myc through induction of the tumor suppressor miR-145.
Proc Natl Acad Sci U S A
2009
Sachdeva M
Zhu S
Wu F
Wu H
Walia V
Kumar S
Elble R
Watabe K
Mo YY
18521080
PubMed
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.
Oncogene
2008
Fornari F
Gramantieri L
Ferracin M
Veronese A
Sabbioni S
Calin GA
Grazi GL
Giovannini C
Croce CM
Bolondi L
Negrini M
20018759
PubMed
miR-221 overexpression contributes to liver tumorigenesis.
Proc Natl Acad Sci U S A
2010
Pineau P
Volinia S
McJunkin K
Marchio A
Battiston C
Terris B
Mazzaferro V
Lowe SW
Croce CM
Dejean A
20351064
PubMed
MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.
J Cell Biol
2010
Quintavalle M
Elia L
Condorelli G
Courtneidge SA
19536137
PubMed
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.
EMBO J
2009
Pothof J
Verkaik NS
van IJcken W
Wiemer EA
Ta VT
van der Horst GT
Jaspers NG
van Gent DC
Hoeijmakers JH
Persengiev SP
17656095
PubMed
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.
Curr Biol
2007
Bommer GT
Gerin I
Feng Y
Kaczorowski AJ
Kuick R
Love RE
Zhai Y
Giordano TJ
Qin ZS
Moore BB
MacDougald OA
Cho KR
Fearon ER
17823410
PubMed
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.
Cancer Res
2007
Corney DC
Flesken-Nikitin A
Godwin AK
Wang W
Nikitin AY
19221490
PubMed
MiR-34, SIRT1 and p53: the feedback loop.
Cell Cycle
2009
Yamakuchi M
Lowenstein CJ
15944709
PubMed
c-Myc-regulated microRNAs modulate E2F1 expression.
Nature
2005
O'Donnell KA
Wentzel EA
Zeller KI
Dang CV
Mendell JT
17135249
PubMed
An E2F/miR-20a autoregulatory feedback loop.
J Biol Chem
2007
Sylvestre Y
De Guire V
Querido E
Mukhopadhyay UK
Bourdeau V
Major F
Ferbeyre G
Chartrand P
19826040
PubMed
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
Cancer Res
2009
Wang P
Zou F
Zhang X
Li H
Dulak A
Tomko RJ Jr
Lazo JS
Wang Z
Zhang L
Yu J
20080624
PubMed
ATM is down-regulated by N-Myc-regulated microRNA-421.
Proc Natl Acad Sci U S A
2010
Hu H
Du L
Nagabayashi G
Seeger RC
Gatti RA
19273599
PubMed
miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.
Mol Cell Biol
2009
Cuesta R
MartÃÂÂnez-Sánchez A
Gebauer F
20406979
PubMed
The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.
Cancer Res
2010
Wong P
Iwasaki M
Somervaille TC
Ficara F
Carico C
Arnold C
Chen CZ
Cleary ML
17135268
PubMed
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.
J Biol Chem
2007
Woods K
Thomson JM
Hammond SM
18949056
PubMed
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
J Clin Invest
2008
Lee SO
Masyuk T
Splinter P
Banales JM
Masyuk A
Stroope A
Larusso N
20029046
PubMed
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.
Blood
2010
Pulikkan JA
Dengler V
Peramangalam PS
Peer Zada AA
Müller-Tidow C
Bohlander SK
Tenen DG
Behre G
18212054
PubMed
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
Mol Cell Biol
2008
Ivanovska I
Ball AS
Diaz RL
Magnus JF
Kibukawa M
Schelter JM
Kobayashi SV
Lim L
Burchard J
Jackson AL
Linsley PS
Cleary MA