This pathway shows the role of microRNAs in the process of cardiac hypertrophy.
Converted from the humane pathway.
MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines.
MicroRNAs are shown as purple rounded rectangles.
It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP1544&oldid=37553 WP1544(r37553)] with a 96% conversion rate.e83e83e83e83b12e83df3df3fbef1ff1ff1fdf3df3f1fdf3dd8df3ec6hypertrophic cardimyopathy pathwayPW:0000296Pathway Ontology16936699PubMedRegulation of cardiac hypertrophy by intracellular signalling pathways.Nat Rev Mol Cell Biol2006Heineke JMolkentin JD10698680PubMedThe PI3K-PDK1 connection: more than just a road to PKB.Biochem J2000Vanhaesebroeck BAlessi DR10086361PubMedCalcineurin and human heart failure.Nat Med1999Lim HWMolkentin JD18342376PubMedThe Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.Trends Pharmacol Sci2008Blankesteijn WMvan de Schans VAter Horst PSmits JF19018142PubMedMicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.Cardiology2009Wang JXu RLin FZhang SZhang GHu SZheng Z20407820PubMedSTAT3 and cardiac remodeling.Heart Fail Rev2010Haghikia AStapel BHoch MHilfiker-Kleiner D17468766PubMedMicroRNA-133 controls cardiac hypertrophy.Nat Med2007Carè ACatalucci DFelicetti FBonci DAddario AGallo PBang MLSegnalini PGu YDalton NDElia LLatronico MVHøydal MAutore CRusso MADorn GW 2ndEllingsen ORuiz-Lozano PPeterson KLCroce CMPeschle CCondorelli G