As described in Hwang, et al., "The interaction of folate and alcohol consumption has been shown to have an antagonistic effect on the risk of oral cancer. Studies have demonstrated that increased intake of folate decreases the risk of oral cancer, while greater alcohol consumption has an opposite effect." This pathway is a hypothetical model for a causal role for P450 2E1 (CYP2E1) and aldehyde dehydrogenase 1 (ALDH1) in oral cancers, implicating folate (via SAM) and alcohol.b5edisease pathwayPW:0000013Pathway Ontologyoral cavity cancerDOID:8618Diseasecancer pathwayPW:0000605Pathway Ontology22100631PubMedAlcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.Med Hypotheses2012Hwang PHLian LZavras AI