As described in Hwang, et al., "The interaction of folate and alcohol consumption has been shown to have an antagonistic effect on the risk of oral cancer. Studies have demonstrated that increased intake of folate decreases the risk of oral cancer, while greater alcohol consumption has an opposite effect." This pathway is a hypothetical model for a causal role for P450 2E1 (CYP2E1) and aldehyde dehydrogenase 1 (ALDH1) in oral cancers, implicating folate (via SAM) and alcohol. b5e disease pathway PW:0000013 Pathway Ontology oral cavity cancer DOID:8618 Disease cancer pathway PW:0000605 Pathway Ontology 22100631 PubMed Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. Med Hypotheses 2012 Hwang PH Lian L Zavras AI