The aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we intentionally focused on information flow, neglecting reactions, metabolites, intracellular movement of components, and their modifications such as protein phosphorylation Each edge can be seen as direct mechanism between its nodes. For more information, see Som A, Harder C, Greber B, Siatkowski M, Paudel Y, et al. 2010 The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165 The June 2010 PluriNetWork described in the paper can be found at http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/ . The PluriNetWork at WikiPathWays started with the December 2010 version. full name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 full name: CREB binding protein full name: reticuloendotheliosis oncogene full name: C-terminal binding protein 1 full name: telomerase reverse transcriptase full name: cyclin-dependent kinase inhibitor 2A full name: transformed mouse 3T3 cell double minute 2 full name: cyclin-dependent kinase inhibitor 1A (P21) full name: zinc finger protein 143 full name: nuclear receptor subfamily 2, group F, member 2 full name: nuclear receptor subfamily 2, group F, member 1 full name: trans-acting transcription factor 1 full name: inactive X specific transcripts full name: myeloproliferative leukemia virus oncogene full name: fibroblast growth factor 4 full name: transcription factor CP2-like 1 full name: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) full name: bone morphogenic protein receptor, type II (serine/threonine kinase) full name: MAD homolog 4 (Drosophila) full name: Notch gene homolog 1 (Drosophila) full name: Harvey rat sarcoma oncogene, subgroup R full name: wingless-related MMTV integration site 5A full name: protein inhibitor of activated STAT 2 full name: Presenilin 1 full name: thyroid peroxidase full name: dickkopf homolog 1 (Xenopus laevis) full name: cerberus 1 homolog (Xenopus laevis) full name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 full name: left right determination factor 1 full name: protein tyrosine phosphatase, receptor type, S full name: F-box protein 15 full name: CDK2 (cyclin-dependent kinase 2)-associated protein 1 full name: methyl-CpG binding domain protein 2 full name: methyl-CpG binding domain protein 3 full name: E1A binding protein p400 full name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) full name: ubiquitin-conjugating enzyme E2I full name: mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) full name: Histone deacetylase 2 full name: Tripartitemotif-containing28 full name: YY1 transcription factor full name: AT rich interactive domain 3B (BRIGHT-like) full name: ring finger protein 2 full name: nuclear receptor subfamily 5, group A, member 2 full name: Transcription factor7 ,T-cell specific full name: REST corepressor 2 full name: cubilin (intrinsic factor-cobalamin receptor) full name: excision repair cross-complementing rodent repair deficiency, complementation group 5 full name: growth arrest and DNA-damage-inducible 45 alpha full name: nuclear receptor subfamily 6, group A, member 1 full name: Rap1 interacting factor 1 homolog (yeast) full name: zinc finger protein 281 full name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing full name: nuclear receptor subfamily 0, group B, member 1 full name: zinc finger protein X-linked full name: myeloblastosis oncogene-like 2 full name: Kruppel-like factor 4 (gut) full name: DEAH (Asp-Glu-Ala-His) box polypeptide 9 full name: RE1-silencing transcription factor full name: THAP domain containing 11 full name: host cell factor C1 full name: POU domain, class 5, transcription factor 1 full name: mitogen-activated protein kinase 3 full name: T-cell lymphoma breakpoint 1 full name: T-box3 full name: inhibitor of DNA binding 1 full name: GATA binding protein 6 full name: POU domain, class 2, transcription factor 1 full name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide full name: growth factor receptor bound protein 2-associated protein 1 full name: Janus kinase 1 full name: suppressorofcytokinesignaling2 full name: interleukin 6 signal transducer full name: leukemia inhibitory factor receptor full name: leukemia inhibitory factor full name: adenomatosis polyposis coli full name: Axin1 full name: lymphoid enhancer binding factor 1 full name: zinc finger protein of the cerebellum 3 full name: tripartite motif-containing 33 full name: FK506 binding protein 12-rapamycin associated protein 1 full name: thymoma viral proto-oncogene 1 full name: myelocytomatosis oncogene full name: caudal type homeo box 2 full name: cyclin D1 full name: signal transducer and activator of transcription 3 full name: sal-like 4 (Drosophila) full name: forkhead box D3 full name: Nanog homeobox full name: SRY-box containing gene 2 full name: damage specific DNA binding protein 1 full name: transformation related protein 53 full name: ES cell-expressed Ras full name: phosphatase and tensin homolog full name: phosphatidylinositol 3-kinase, catalytic delta polypeptide full name: mitogen-activated protein kinase kinase 1 full name: v-raf-leukemia viral oncogene 1 full name: Harvey rat sarcoma virus oncogene 1 full name: MAD homolog 2 (Drosophila) full name: transforming growth factor, beta receptor I / ALK5 full name: Nodal homolog full name: heterogeneous nuclear ribonucleoprotein U full name: fibroblast growth factor receptor 1 full name: bone morphogenetic protein 4 full name: activin A receptor, type 1 full name: MAD homolog 1 (Drosophila) full name: cadherin 1 full name: catenin (cadherin associated protein), beta 1 full name: transcription factor 3 full name: integrin beta 1 (fibronectin receptor beta) full name: glycogen synthase kinase 3 beta full name: dishevelled, dsh homolog 1 (Drosophila) full name: histone deacetylase 4 full name: PHD finger protein 17 full name: frizzled homolog 1 (Drosophila) full name: low density lipoprotein receptor-related protein 5 full name: wingless-related MMTV integration site 3A full name: protein tyrosine phosphatase, non-receptor type 11 full name: growthfactorreceptor-boundprotein2 full name: zinc finger protein 42 full name: E1A binding protein p300 full name: undifferentiated embryonic cell transcription factor 1 full name: estrogen related receptor, beta full name: polyhomeotic-like 1 (Drosophila) full name: zinc finger protein of the cerebellum 2 full name: ets variant gene 5 full name: transcription factor AP-2, gamma full name: orthodenticle homolog 2 (Drosophila) full name: zinc finger protein 219 full name: RING1 and YY1 binding protein full name: Transducin-likeenhancerofsplit4 full name: recombination signal binding protein for immunoglobulin kappa J region full name: sal-like 1 (Drosophila) full name: FBJ osteosarcoma oncogene full name: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) full name: transcription factor E3 full name: K(lysine) acetyltransferase 5 full name: Son of sevenless homolog 1 (Drosophila) full name: inhibin beta-B full name: transforming growth factor, beta 1 full name: MADhomolog7 full name: Ewing sarcoma breakpoint region 1 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 full name: poly (ADP-ribose) polymerase family, member 1 full name: CCCTC-binding factor full name: X (inactive)-specific transcript, antisense full name: microphthalmia-associated transcription factor full name: X-inactivation intergenic transcription element full name: lysine (K)-specific demethylase 4C full name: lysine (K)-specific demethylase 3A full name: zinc finger protein 57 full name: karyopherin (importin) alpha 2 full name: caspase 3 full name: reticulon 4 receptor full name: CD44 antigen full name: mitogen-activated protein kinase 1 full name: non-metastatic cells 2, protein (NM23B) expressed in full name: transcription factor EB full name: euchromatic histone lysine N-methyltransferase 2 full name: DNA (cytosine-5-)-methyltransferase 3-like full name: insulin receptor substrate 1 full name: insulin receptor full name: insulin I full name: sonic hedgehog full name: smoothened homolog (Drosophila) full name: euchromatic histone methyltransferase 1 full name: growth arrest and DNA-damage-inducible, gamma interacting protein 1 full name: nuclear receptor coactivator 1 full name: C-terminal binding protein 2 full name: protein kinase, cAMP dependent, catalytic, alpha full name: DNA methyltransferase 3A full name: DNA methyltransferase 3B full name: transcription factor AP-2, alpha full name: special AT-rich sequence binding protein 1 full name: special AT-rich sequence binding protein 2 full name: paired box gene 6 full name: secreted phosphoprotein 1 full name: protein inhibitor of activated STAT 4; PIASy full name: WW domain containing E3 ubiquitin protein ligase 2 full name: cAMP responsive element binding protein 1 full name: ubiquitin-like, containing PHD and RING finger domains, 1 full name: reticulocalbin 2 full name: serine/threonine kinase 40 full name: fibroblast growth factor 5 full name: deleted in azoospermia-like full name: G-rich RNA sequence binding factor 1 full name: amino-terminal enhancer of split full name: proviral integration site 1 full name: proviral integration site 3 full name: occludin full name: activating transcription factor 2 full name: intercellular adhesion molecule 1 full name: breast cancer 1 full name: SMT3 suppressor of mif two 3 homolog 1 (yeast) full name: tet oncogene 1 full name: brachyury full name: gastrulation brain homeobox 2 full name: nuclear receptor subfamily 2, group F, member 6 full name: nuclear receptor subfamily 2, group C, member 1 full name: splicing factor 1 full name: ubiquitin specific peptidase 7 full name: calcineurin binding protein 1 full name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 full name: Rho-associated coiled-coil containing protein kinase 1 full name: Rho-associated coiled-coil containing protein kinase 2 full name: protein kinase C, gamma full name: RIKEN cDNA E130012A19 gene full name: insulin-like growth factor binding protein 3 full name: basal cell adhesion molecule full name: RIKEN cDNA 1600029D21 gene full name: PERP, TP53 apoptosis effector full name: diacylglycerol kinase, alpha full name: histone cell cycle regulation defective homolog A (S. cerevisiae) full name: family with sequence similarity 129, member A full name: hemopoietic cell kinase full name: activin A receptor, type IC / Alk7 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 full name: structure specific recognition protein 1 full name: sal-like 3 (Drosophila) full name: chromodomain helicase DNA binding protein 4 full name: H3 histone, family 3A full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human) full name: naked cuticle 1 homolog (Drosophila) full name: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform full name: NOBOX oogenesis homeobox full name: growth differentiation factor 9 full name: activin A receptor, type 1B / Alk4 full name: metal response element binding transcription factor 2 / PCL2 full name: retinoblastoma binding protein 4 full name: retinoblastoma binding protein 7 full name: suppressor of zeste 12 homolog (Drosophila) full name: jumonji, AT rich interactive domain 2 full name: natriuretic peptide precursor type B full name: natriuretic peptide receptor 1 full name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase full name: DNA fragmentation factor, alpha subunit full name: enhancer of zeste homolog 2 (Drosophila) full name: MAD homolog 3 (Drosophila) full name: enhancer of zeste homolog 1 (Drosophila) full name: embryonic ectoderm development full name: importin 7 full name: karyopherin (importin) beta 1 full name: exportin 4 full name: importin 9 full name: trans-acting transcription factor 3 full name: telomeric repeat binding factor 2 full name: heart and neural crest derivatives expressed transcript 2 full name: dihydropyrimidinase-like 2 full name: lysine (K)-specific demethylase 5C full name: KDM1 lysine (K)-specific demethylase 6B full name: myeloid/lymphoid or mixed-lineage leukemia 2, ALR full name: 4lysine (K)-specific demethylase 6A full name: myocyte enhancer factor 2C full name: myocyte enhancer factor 2D full name: myogenic differentiation 1 full name: SMAD specific E3 ubiquitin protein ligase 1 full name: serum/glucocorticoid regulated kinase 1 full name: neural precursor cell expressed, developmentally down-regulated gene 4-like full name: hypoxia inducible factor 1, alpha subunit full name: developmental pluripotency associated 4 full name: Kruppel-like factor 2 (lung) full name: helicase, lymphoid specific full name: DNA methyltransferase (cytosine-5) 1 full name: Ctr9 (Alco called "SH2 domain-binding protein 1") full name: Leo1 full name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog full name: WD repeat domain 61 full name: coactivator-associated arginine methyltransferase 1 full name: retinoblastoma-like 2 full name: cyclin-dependent kinase 2 full name: avian reticuloendotheliosis viral (v-rel) oncogene related B full name: SET domain, bifurcated 1 full name: nucleolin full name: Ly1 antibody reactive clone full name: tripartite motif-containing 24 full name: twist gene homolog 1 (Drosophila) full name: zinc finger and SCAN domain containing 10 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 full name: promyelocytic leukemia full name: lysine (K)-specific demethylase 1A full name: GATA zinc finger domain containing 2A full name: v-rel reticuloendotheliosis viral oncogene homolog A (avian) full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 full name: GATA zinc finger domain containing 2B full name: polybromo 1 / BAF180 full name: histone deacetylase 1 full name: metastasis associated 1 full name: transcriptional regulator, SIN3A (yeast) full name: Kruppel-like factor 5 full name: metastasis-associated gene family, member 2 full name: zinc finger, MYM-type 2 full name: transducin-like enhancer of split 2, homolog of Drosophila E(spl) b00 b00 b90 b1000 b510 b1011 b510 b510 b1011 b1050 b1050 b1050 b1050 b1050 b110 b1050 b1050 b1050 b900 b900 b911 b1150 b1160 b1160 b1180 b1190 b110 b121 b1190 b1201 b1210 b1210 b1230 b1231 b1230 b1231 b350 b1260 b911 b1270 b1280 b1280 b110 b40 b1310 b1310 b1330 b1310 b1350 b1360 b1360 b1380 b1380 b110 b121 b1400 b1410 b1420 b40 b40 b1450 b1460 b1460 b1460 b40 b110 b1500 b1510 b1520 b1000 b1000 b900 b900 b1570 b1570 b900 b110 b1600 b970 b1620 b1620 b1640 b1650 b1660 b1661 b1662 b1670 b1671 b1670 b1670 b110 b1670 b1670 b1670 b1670 b1670 b1670 b1670 b1770 b1770 b1770 b110 b1770 b1770 b1770 b1770 b1770 b1770 b1670 b1670 b1670 b1670 b1900 b1910 b1920 b1660 b1230 b1923 b1660 b1923 b1660 b1770 b1960 b1961 b1960 b1961 b1961 b1990 b00 b110 b1662 b2010 b2010 b2030 b2040 b2050 b2060 b2061 b1280 b2061 b1280 b510 b2082 b510 b110 b211 b2060 b2060 b410 b510 b2140 b2140 b1570 b2170 b2180 b911 b110 b911 b911 b911 b911 b911 b911 b911 b911 b911 b911 b211 b911 b911 b911 b911 b911 b911 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b1260 b3531 b2680 b2610 b2690 b1260 b1960 b1670 b3791 b380 b1923 b1670 b1671 b1670 b1670 b1923 b1960 b1960 b1961 b1960 b1960 b1280 b390 b1670 b1670 b1670 b1670 b1670 b1280 b1670 b3952 b900 b900 b900 b900 b40 b390 b900 b900 b900 b900 b3260 b3660 b2960 b3301 b3952 b2180 b410 b2610 b2620 b2630 b2630 b4140 b2690 b1260 b1620 b1280 b1670 b2842 b4173 b2830 b1670 b1280 b4183 b2821 b410 b2680 b1670 b410 b1670 b1670 b1670 b1670 b1670 b1670 b1670 b430 b431 b1280 b2842 b1923 b1670 b1670 b1670 b3121 b4360 b4361 b4370 b4370 b4173 b430 b4400 b4410 b2833 b1380 b4422 b4430 b1270 b1923 b4433 b1270 b3040 b1923 b4430 b4461 b1380 b4471 b1270 b1270 b430 b1310 b1310 b1270 b1270 b00 b00 b00 b00 b00 b1270 b1270 b430 b4600 b4600 b1380 b4630 b4630 b1280 b1280 b1280 b1380 b1380 b4691 b470 b1260 b3100 b1660 b1380 b4740 b3700 b1160 b1380 b4770 b4770 b4790 b470 b4790 b4691 b1160 b1380 b1380 b4830 b4691 b2833 b4790 b4691 b4843 b1160 b1380 b1160 b1160 b1160 b470 b1160 b1310 b1310 b1380 b1380 b1380 b1380 b1380 b1270 b3340 b1380 b1380 b50 b500 b1380 b1380 b3121 b1270 b1270 b1270 b5060 b5070 b5080 b3370 b510 b3370 b3370 b2630 b2630 b2630 b2630 b3791 b1280 b3952 b1670 b5181 b5181 b510 b5181 b1670 b1670 b1670 b1670 b1670 b1670 b1670 b1670 b1670 b510 b1960 b911 b1960 b5320 b5330 b641 b570 b570 b641 b570 b1270 b1270 b540 b00 b00 b00 b00 b00 b00 b5460 b1960 b5480 b5480 b540 b2900 b2900 b2900 b2900 b260 b5550 b5560 b3370 b3370 b540 b431 b5610 b5620 b5630 b5630 b5650 b5650 b5670 b5671 b5670 b5671 b5670 b5671 b570 b5700 b1600 b1600 b5730 b5740 b5750 b5750 b5770 b5770 b5770 b570 b2980 b5810 b5820 b5821 b5830 b5830 b5850 b2990 b5870 b5880 b1510 b570 b5900 b3301 b1231 b5930 b5940 b1201 b5960 b60 b570 b570 b570 b570 b570 b641 b641 b570 b641 b570 b641 b570 b641 b570 b641 b570 b70 b570 b641 b570 b641 b720 b720 b720 b750 b750 b770 b771 b771 b771 b770 b80 b800 b810 b820 b830 b830 b830 b830 b870 b830 b870 b870 b90 b900 b900 b911 b900 b930 b900 b900 b900 b970 b970 b900

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