Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop". Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1772 CPTAC Assay Portal] bc6 cda regulatory pathway PW:0000004 Pathway Ontology 20808857 PubMed Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. PLoS One 2010 Rückert F Dawelbait G Winter C Hartmann A Denz A Ammerpohl O Schroeder M Schackert HK Sipos B Klöppel G Kalthoff H Saeger HD Pilarsky C Grأ¼tzmann R signaling pathway PW:0000003 Pathway Ontology apoptotic cell death pathway PW:0000009 Pathway Ontology 17404574 PubMed mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007 Mott JL Kobayashi S Bronk SF Gores GJ