Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases. Description adapted from [https://en.wikipedia.org/wiki/Proteasome Wikipedia]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP183 CPTAC Assay Portal] e91 PRS6 HUMAN U13393 PRS6 HUMAN e3b

ubiquitin/proteasome degradation pathway PW:0000144 Pathway Ontology 11017125 PubMed Basic Medical Research Award. The ubiquitin system. Nat Med 2000 Hershko A Ciechanover A Varshavsky A 22307589 PubMed Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A 2012 Lasker K Förster F Bohn S Walzthoeni T Villa E Unverdorben P Beck F Aebersold R Sali A Baumeister W