Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.b50c61d8ab72bd6c9eae80ebffc3ac43be2a7099d7886ddf14a93fedd31tenascin Rvitronectinintegrin, alpha 7integrin, alpha Mintegrin, beta 1integrin, beta 2integrin, beta 6integrin, beta 7RAP1A; RAP1A member of RAS oncogene familyRAP1B; RAP1B member of RAS oncogene familySHC1; SHC (Src homology 2 domain containing) transforming protein 1SHC3; neuronal ShZYX; zyxinCAV1; caveolin 1 caveolae protein 22kDCAV3; caveolin 3FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]GRB2; growth factor receptor-bound protein 2SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]ILK; integrin-linked kinase [EC:2.7.1.-]CAV2; caveolin 2actinin, alpha 1chondroadherincollagen, type II, alpha 1collagen, type III, alpha 1collagen, type IV, alpha 1collagen, type IV, alpha 4collagen, type V, alpha 1collagen, type I, alpha 1fibronectin 1integrin-binding sialoproteinlaminin, gamma 2reelinsecreted phosphoprotein 1BLK proto-oncogene, Src family tyrosine kinaseepidermal growth factor receptorv-erb-b2 avian erythroblastic leukemia viral oncogene 2FGR proto-oncogene, Src family tyrosine kinaseFMS-related tyrosine kinase 1hemopoietic cell kinaseinsulin-like growth factor 1 receptorMET proto-oncogene, receptor tyrosine kinaseplatelet derived growth factor receptor, alpha polypeptideplatelet derived growth factor receptor, beta polypeptidesrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesTXK tyrosine kinasetestis-specific kinase 2tyrosine kinase, non-receptor, 2ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112Rho GTPase activating protein 5ras homolog family member Bpaxillincalpain 1, (mu/I) large subunitras homolog family member A3-phosphoinositide dependent protein kinase-1v-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene homolog 2Rho-associated coiled-coil containing protein kinase 1Rho-associated coiled-coil containing protein kinase 2phosphatidylinositol-4-phosphate 5-kinase, type I, gammamyosin light chain kinase 2actin, betaactin, gamma 1glycogen synthase kinase 3 betaphosphoinositide-3-kinase, regulatory subunit 1phosphoinositide-3-kinase, regulatory subunit 2 (beta)phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaphosphatase and tensin homologras-related C3 botulinum toxin substrate 1ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)p21 protein (Cdc42/Rac)-activated kinase 1p21 protein (Cdc42/Rac)-activated kinase 3p21 protein (Cdc42/Rac)-activated kinase 2platelet derived growth factor Cvascular endothelial growth factor Avascular endothelial growth factor Bvascular endothelial growth factor Cbreast cancer anti-estrogen resistance 1v-crk avian sarcoma virus CT10 oncogene homologRap guanine nucleotide exchange factorcell division cycle 42BCL2-associated agonist of cell deathB-cell CLL/lymphoma 2baculoviral IAP repeat-containing 2baculoviral IAP repeat-containing 3X-linked inhibitor of apoptosis, also known as Birc4, Api3, riap3mitogen-activated protein kinase 9jun proto-oncogenecyclin D1cyclin D2collagen, type XI, alpha 1collagen, type V, alpha 2collagen, type VI, alpha 2laminin, alpha 3laminin, alpha 4laminin, alpha 5laminin, beta 2laminin, beta 3thrombospondin 1thrombospondin 2thrombospondin 3tenascin Ccollagen, type IV, alpha 6tenascin XBunknown gene product, LOC235580 was replaced by Col6a4 collagen, type VI, alpha 4 (M. musculus), Gene ID: 68553, updated on 17-Mar-2015platelet derived growth factor Dplatelet-derived growth factor beta polypeptidekinase insert domain receptorintegrin, beta 5integrin, beta 3integrin, alpha Eintegrin, alpha Vintegrin, alpha Lintegrin, alpha Dintegrin, alpha 8integrin, alpha 9integrin, alpha 2Bintegrin, alpha 6integrin, alpha 2Bfilamin A, alphatalin 1phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alphamitogen-activated protein kinase 8cyclin D3SOS1; 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