Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria.
Source: [[wikipedia:Cholesterol|Wikipedia]]
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP197 CPTAC Assay Portal]
ec9
d9b
e32
c8f
ea9
cdc
e73
de6
NAD(P) dependent steroid dehydrogenase-like
12235098
PubMed
Malformation syndromes due to inborn errors of cholesterol synthesis.
J Clin Invest
2002
Porter FD
cholesterol biosynthetic pathway
PW:0000454
Pathway Ontology