This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1971 CPTAC Assay Portal]OncogeneTumor supressor
Oncogene
Phosphorylated
Phosphorylatedcd5b3bc38dc720086245PubMedmicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.Blood2010Zhao JJLin JLwin TYang HGuo JKong WDessureault SMoscinski LCRezania DDalton WSSotomayor ETao JCheng JQ18591254PubMedMicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.Mol Cell Biol2008Gabriely GWurdinger TKesari SEsau CCBurchard JLinsley PSKrichevsky AM21359530PubMedmiR-29b regulates migration of human breast cancer cells.Mol Cell Biochem2011Wang CBian ZWei DZhang JGcancer pathwayPW:0000605Pathway Ontology17681183PubMedMicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.Gastroenterology2007Meng FHenson RWehbe-Janek HGhoshal KJacob STPatel TcancerDOID:162Disease