Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.
NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2032 CPTAC Assay Portal]ea7d83IL-4 stimulated the phosphorylation of STAT3 and activated its nuclear translocation in mouse T (CD8+) cells..IL-4 induces the Jak3-mediated phosphorylation and nuclear migration of STAT1, STAT3, and STAT5 in Spleen CD8+ T cells.IL-4 leads to interaction of IL-4R alpha conseved motif ITIM with SHP-1.21996254PubMedA comprehensive curated resource for follicle stimulating hormone signaling.BMC Res Notes2011Telikicherla DAmbekar APalapetta SMDwivedi SBRaju RSharma JPrasad TsKRamachandra YMohan SSMaharudraiah JMukherjee SPandey Athyroid-stimulating hormone signaling pathwayPW:0001200Pathway Ontology20067622PubMedNetPath: a public resource of curated signal transduction pathways.Genome Biol2010Kandasamy KMohan SSRaju RKeerthikumar SKumar GSVenugopal AKTelikicherla DNavarro JDMathivanan SPecquet CGollapudi SKTattikota SGMohan SPadhukasahasram HSubbannayya YGoel RJacob HKZhong JSekhar RNanjappa VBalakrishnan LSubbaiah RRamachandra YLRahiman BAPrasad TSLin JXHoutman JCDesiderio SRenauld JCConstantinescu SNOhara OHirano TKubo MSingh SKhatri PDraghici SBader GDSander CLeonard WJPandey A