Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing this pathway, please reference the source publication (PMID: 19575671). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2064) b40 e22 b42 e36 ec7 cac e64 f97 c16 a91 a91 inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation inhitory transcriptional regulation 19575671 PubMed Assembling neural crest regulatory circuits into a gene regulatory network. Annu Rev Cell Dev Biol 2010 Betancur P Bronner-Fraser M Sauka-Spengler T 21108791 PubMed Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. BMC Dev Biol 2010 Takahashi KF Kiyoshima T Kobayashi I Xie M Yamaza H Fujiwara H Ookuma Y Nagata K Wada H Sakai T Terada Y Sakai H regulatory pathway PW:0000004 Pathway Ontology 12815623 PubMed Hoxb1 neural crest preferentially form glia of the PNS. Dev Dyn 2003 Arenkiel BR Gaufo GO Capecchi MR 15731351 PubMed The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Proc Natl Acad Sci U S A 2005 Filippi A Tiso N Deflorian G Zecchin E Bortolussi M Argenton F 16402914 PubMed The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. Biochem J 2006 Borghini S Bachetti T Fava M Di Duca M Cargnin F Fornasari D Ravazzolo R Ceccherini I neuron neural crest derived CL:0000029 Cell Type 16845469 PubMed Generation and maintenance of Dmbx1 gene-targeted mutant alleles. Mamm Genome 2006 Ohtoshi A Bradley A Behringer RR Nishijima I cranial neural crest cell CL:0000008 Cell Type 15944192 PubMed AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Development 2005 Knight RD Javidan Y Zhang T Nelson S Schilling TF 14973296 PubMed Reiterated Wnt signaling during zebrafish neural crest development. Development 2004 Lewis JL Bonner J Modrell M Ragland JW Moon RT Dorsky RI Raible DW 21784065 PubMed Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol 2011 Makki N Capecchi MR 20083100 PubMed A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus. Dev Biol 2010 Callery EM Thomsen GH Smith JC