Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143
When citing this pathway, please reference the source publication (PMID: 19575671).
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2064 CPTAC Assay Portal]b40e22b42e36ec7cace64f97c16a91a91inhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationinhitory transcriptional regulationregulatory pathwayPW:0000004Pathway Ontologyneuron neural crest derivedCL:0000029Cell Ontologycranial neural crest cellCL:0000008Cell Ontology19575671PubMedAssembling neural crest regulatory circuits into a gene regulatory network.Annu Rev Cell Dev Biol2010Betancur PBronner-Fraser MSauka-Spengler T14973296PubMedReiterated Wnt signaling during zebrafish neural crest development.Development2004Lewis JLBonner JModrell MRagland JWMoon RTDorsky RIRaible DW12815623PubMedHoxb1 neural crest preferentially form glia of the PNS.Dev Dyn2003Arenkiel BRGaufo GOCapecchi MR21108791PubMedProtogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.BMC Dev Biol2010Takahashi KFKiyoshima TKobayashi IXie MYamaza HFujiwara HOokuma YNagata KWada HSakai TTerada YSakai H15731351PubMedThe basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.Proc Natl Acad Sci U S A2005Filippi ATiso NDeflorian GZecchin EBortolussi MArgenton F20083100PubMedA divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.Dev Biol2010Callery EMThomsen GHSmith JC21784065PubMedIdentification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.Dev Biol2011Makki NCapecchi MR16402914PubMedThe TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.Biochem J2006Borghini SBachetti TFava MDi Duca MCargnin FFornasari DRavazzolo RCeccherini I15944192PubMedAP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.Development2005Knight RDJavidan YZhang TNelson SSchilling TF16845469PubMedGeneration and maintenance of Dmbx1 gene-targeted mutant alleles.Mamm Genome2006Ohtoshi ABradley ABehringer RRNishijima I