The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2113 CPTAC Assay Portal]. Jak-Stat signaling pathway PW:0000209 Pathway Ontology interleukin-29 signaling pathway PW:0000893 Pathway Ontology interleukin-28A signaling pathway PW:0000891 Pathway Ontology interleukin-28B signaling pathway PW:0000892 Pathway Ontology