Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal]adenylate cyclaseProstaglandin I2 ReceptorCalponin; tonically inhibits the ATPase activity of myosin in smooth muscleType your comment heremyosine light chainCalmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contractionType your comment hereinhibition by phosphorylation and thereby preventing association with CaMInhibition by phosphorylationType your comment herestimulation by phosphorylationType your comment hereInhibition by phosphorylationType your comment hereSympathic nerveSensory motor nerveblood vessel endothelial cellCL:0000071Cell OntologyG protein mediated signaling pathway via Galphaq familyPW:0000229Pathway Ontologybenign essential hypertensionDOID:10913Human Disease OntologyRas superfamily mediated signaling pathwayPW:0000006Pathway OntologyG protein mediated signaling pathway via Galphai familyPW:0000228Pathway OntologyG protein mediated signaling pathway via Galphas familyPW:0000227Pathway Ontologyendothelin signaling pathwayPW:0000506Pathway Ontologysmooth muscle cellCL:0000192Cell Ontologycalcium/calmodulin dependent signaling pathwayPW:0000314Pathway OntologyhypertensionDOID:10763Human Disease Ontology