Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal] adenylate cyclase Prostaglandin I2 Receptor Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle Type your comment here myosine light chain Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction Type your comment here inhibition by phosphorylation and thereby preventing association with CaM Inhibition by phosphorylation Type your comment here stimulation by phosphorylation Type your comment here Inhibition by phosphorylation Type your comment here Sympathic nerve Sensory motor nerve blood vessel endothelial cell CL:0000071 Cell Ontology G protein mediated signaling pathway via Galphaq family PW:0000229 Pathway Ontology benign essential hypertension DOID:10913 Human Disease Ontology Ras superfamily mediated signaling pathway PW:0000006 Pathway Ontology G protein mediated signaling pathway via Galphai family PW:0000228 Pathway Ontology G protein mediated signaling pathway via Galphas family PW:0000227 Pathway Ontology endothelin signaling pathway PW:0000506 Pathway Ontology smooth muscle cell CL:0000192 Cell Ontology calcium/calmodulin dependent signaling pathway PW:0000314 Pathway Ontology hypertension DOID:10763 Human Disease Ontology