Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis.
Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC, E2F3 and cyclin-dependent kinase(CDK6).
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2249 CPTAC Assay Portal]
e18
d08
f67
a71
disease pathway
PW:0000013
Pathway Ontology
disease of cellular proliferation
DOID:14566
Human Disease Ontology
20371350
PubMed
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Cell
2010
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PubMed
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Cell Death Differ
2010
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19461653
PubMed
The miR-34 family in cancer and apoptosis.
Cell Death Differ
2010
Hermeking H
19079265
PubMed
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.
Nat Struct Mol Biol
2009
Park SY
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Kim VN