This pathway shows the relationship between BRAF signalling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation.
BRAF is related in two alternative mechanisms in MAPK activation; first oncogenic fusion between SRGAP3 and RAF1 (highlighted in yellow); second a 3 basepair insertion in BRAF (KIAA1549, again in yellow).
This pathway is based on Figure 3" An overview of MAPK pathway alterations in PAs" from [https://doi.org/10.1038/onc.2009.73 Jones et al].a4cRTKs have to be activated first"RTK promotes Ras activation through recruitement of Grb2/Sos complexes" [PMID:17496910]de117496910PubMedIntegrating signals from RTKs to ERK/MAPK.Oncogene2007McKay MMMorrison DKmitogen activated protein kinase signaling pathwayPW:0000007Pathway OntologyastrocytomaDOID:3069Diseaseglioma pathwayPW:0000711Pathway Ontologypilocytic astrocytomaDOID:4851Disease19363522PubMedOncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.Oncogene2009Jones DTKocialkowski SLiu LPearson DMIchimura KCollins VPcancerDOID:162Disease