The most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core pathways by TCGA, The Cancer Genome Atlas (see Bibliography). Assembled from literature and public pathway database resources, this representation can easily be kept up to date at WikiPathways.org.
Sources: [http://cbio.mskcc.org/cancergenomics/gbm/pathways/GBM_pathway_20080708.pdf cBio Cancer Genomics Portal]
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2261 CPTAC Assay Portal]e3fc9ddbcd5edbca99dbcc17glioblastCL:0000030Cell TypeFGF signaling pathwayPW:0000328Pathway OntologyArf family mediated signaling pathwayPW:0000387Pathway Ontology18772890PubMedComprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature2008glioblastomaDOID:3068Disease19419954PubMedUp-regulation of miR-21 by HER2/neu signaling promotes cell invasion.J Biol Chem2009Huang THWu FLoeb GBHsu RHeidersbach ABrincat AHoriuchi DLebbink RJMo YYGoga AMcManus MT21078976PubMedMicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).Proc Natl Acad Sci U S A2010Valeri NGasparini PBraconi CPaone ALovat FFabbri MSumani KMAlder HAmadori DPatel TNuovo GJFishel RCroce CM20048743PubMedDownregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.Lab Invest2010Zhou XRen YMoore LMei MYou YXu PWang BWang GJia ZPu PZhang WKang C21934092PubMedMicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.Carcinogenesis2011Liu XZhang ZSun LChai NTang SJin JHu HNie YWang XWu KJin HFan Dphosphatidylinositol 3-kinase class I signaling pathwayPW:0000963Pathway Ontologyepidermal growth factor/neuregulin signaling pathwayPW:0000170Pathway Ontologyphosphatidylinositol 3-kinase class II signaling pathwayPW:0000965Pathway Ontology21278789PubMedDownregulation of Spry2 by miR-21 triggers malignancy in human gliomas.Oncogene2011Kwak HJKim YJChun KRWoo YMPark SJJeong JAJo SHKim THMin HSChae JSChoi EJKim GShin SHGwak HSKim SKHong EKLee GKChoi KHKim JHYoo HPark JBLee SHp53 signaling pathwayPW:0000718Pathway Ontologythe extracellular signal-regulated Raf/Mek/Erk signaling pathwayPW:0000102Pathway Ontologybrain cancerDOID:1319DiseasecancerDOID:162Diseaseglioma pathwayPW:0000711Pathway Ontologyprotein kinase C (PKC) signaling pathwayPW:0000840Pathway Ontology