Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2369 CPTAC Assay Portal] d4b K9ac f41 b4c e4d d3a altered transcription pathway PW:0000807 Pathway Ontology 12435631 PubMed Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002 Kuzmichev A Nishioka K Erdjument-Bromage H Tempst P Reinberg D 15145825 PubMed A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 2004 Schotta G Lachner M Sarma K Ebert A Sengupta R Reuter G Reinberg D Jenuwein T 11805083 PubMed COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 2002 Krogan NJ Dover J Khorrami S Greenblatt JF Schneider J Johnston M Shilatifard A 10949293 PubMed Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 2000 Rea S Eisenhaber F O'Carroll D Strahl BD Sun ZW Schmid M Opravil S Mechtler K Ponting CP Allis CD Jenuwein T 11839797 PubMed Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol 2002 Strahl BD Grant PA Briggs SD Sun ZW Bone JR Caldwell JA Mollah S Cook RG Shabanowitz J Hunt DF Allis CD