G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC Assay Portal] CAA71233 - human AA# human Acc# BAA13103 CAA71233 - human AA# aa2

27237973 PubMed G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. Biochem Biophys Res Commun 2016 Kukkonen JP G protein mediated signaling pathway PW:0000125 Pathway Ontology