Describes the role of retinoblastoma (RB) gene in cancer.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2446 CPTAC Assay Portal]dc0cbcb17f50dbbfa4e1edisease pathwayPW:0000013Pathway Ontologycancer pathwayPW:0000605Pathway OntologycancerDOID:162Human Disease Ontology7565706PubMedAbrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.Mol Cell Biol1995Welch PJWang JY9528081PubMed[Leukoencephalopathy: the frontier between what is reversible and what is persistent].Rev Neurol1997DomÃnguez RFamulari AVila J8242749PubMedA C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.Cell1993Welch PJWang JY21078976PubMedMicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).Proc Natl Acad Sci U S A2010Valeri NGasparini PBraconi CPaone ALovat FFabbri MSumani KMAlder HAmadori DPatel TNuovo GJFishel RCroce CM18591254PubMedMicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.Mol Cell Biol2008Gabriely GWurdinger TKesari SEsau CCBurchard JLinsley PSKrichevsky AM15469821PubMedAn Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.Mol Cell2004Ji PJiang HRekhtman KBloom JIchetovkin MPagano MZhu L19850741PubMedMicroRNA 29b functions in acute myeloid leukemia.Blood2009Garzon RHeaphy CEHavelange VFabbri MVolinia STsao TZanesi NKornblau SMMarcucci GCalin GAAndreeff MCroce CM