Describes the role of retinoblastoma (RB) gene in cancer. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2446). dc0 cbc b17 f50 dbb fa4 e1e 19850741 PubMed MicroRNA 29b functions in acute myeloid leukemia. Blood 2009 Garzon R Heaphy CE Havelange V Fabbri M Volinia S Tsao T Zanesi N Kornblau SM Marcucci G Calin GA Andreeff M Croce CM 9528081 PubMed [Leukoencephalopathy: the frontier between what is reversible and what is persistent]. Rev Neurol 1997 Domínguez R Famulari A Vila J disease pathway PW:0000013 Pathway Ontology 18591254 PubMed MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 2008 Gabriely G Wurdinger T Kesari S Esau CC Burchard J Linsley PS Krichevsky AM cancer pathway PW:0000605 Pathway Ontology 8242749 PubMed A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 1993 Welch PJ Wang JY 15469821 PubMed An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell 2004 Ji P Jiang H Rekhtman K Bloom J Ichetovkin M Pagano M Zhu L cancer DOID:162 Disease 7565706 PubMed Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Mol Cell Biol 1995 Welch PJ Wang JY 21078976 PubMed MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A 2010 Valeri N Gasparini P Braconi C Paone A Lovat F Fabbri M Sumani KM Alder H Amadori D Patel T Nuovo GJ Fishel R Croce CM