Programmed cell death: regulated necrosis. During regulated necrosis, different stimuli are recognized or sensed by specific receptors on the cell surface or inside cells. The activation of the necrosome stimulates different signaling pathways leading to mitochondrial hyperpolarization, lysosomal membrane permeabilization, and generation of reactive oxygen species (ROS), leading to cellular disintegration. A recent study revealed that germanium nanoparticles trigger necrostatin-1-inhibitable cell death with a reduction of the mitochondrial membrane potential.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2513 CPTAC Assay Portal]b1cd9cnanomaterial response pathwayPW:0001435Pathway Ontologynecrosis pathwayPW:0000279Pathway Ontology22720979PubMedProgrammed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.Acc Chem Res2012Andón FTFadeel B21979174PubMedWater-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.Toxicol Lett2011Ma YHHuang CPTsai JSShen MYLi YKLin LY