Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenic effects through the activation of several downstream pathways such as Pi3K/akt, IRF4, and NFkB pathways. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP262) cf5 d73 ee4 b42 "Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation." Source: https://en.wikipedia.org/wiki/SCF_complex Annotations have been derived from Complex Portal, filtering for 'curated complex', confidence score 5 stars, species H. sapiens, and component type protein (giving 10 results on 2026-01-30; 6 directly relevant and added to this pathway) Epstein-Barr virus infection pathway PW:0001057 Pathway Ontology 18089854 PubMed Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol 2008 Battaglia F Delfino S Merello E Puppo M Piva R Varesio L Bosco MC 16446357 PubMed TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem 2006 Uemura N Kajino T Sanjo H Sato S Akira S Matsumoto K Ninomiya-Tsuji J 16477006 PubMed IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A 2006 Song YJ Jen KY Soni V Kieff E Cahir-McFarland E 18052967 PubMed Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Scand J Immunol 2008 Lee JS Lee JY Son JW Oh JH Shin DM Yuk JM Song CH Paik TH Jo EK oxidative phosphorylation pathway PW:0001059 Pathway Ontology