Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenice effects through the activation of several downstream pathways suchs as Pi3K/akt, IRF4, and NFkB pathways.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP262 CPTAC Assay Portal]cf5d73ee4b42Type your comment hereEpstein-Barr virus infection pathwayPW:0001057Pathway Ontologyoxidative phosphorylation pathwayPW:0001059Pathway Ontology16446357PubMedTAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.J Biol Chem2006Uemura NKajino TSanjo HSato SAkira SMatsumoto KNinomiya-Tsuji J16477006PubMedIL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.Proc Natl Acad Sci U S A2006Song YJJen KYSoni VKieff ECahir-McFarland E18052967PubMedExpression and regulation of the CC-chemokine ligand 20 during human tuberculosis.Scand J Immunol2008Lee JSLee JYSon JWOh JHShin DMYuk JMSong CHPaik THJo EK18089854PubMedHypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.J Leukoc Biol2008Battaglia FDelfino SMerello EPuppo MPiva RVaresio LBosco MC