Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response.
During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2795 CPTAC Assay Portal]ba8cardiac muscle cellCL:0000746Cell Ontologyhypertrophic cardiomyopathyDOID:11984Human Disease Ontologyhypertrophic cardiomyopathy pathwayPW:0000296Pathway Ontology16936699PubMedRegulation of cardiac hypertrophy by intracellular signalling pathways.Nat Rev Mol Cell Biol2006Heineke JMolkentin JD