The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: [Induction](https://www.wikipathways.org/index.php/Pathway:WP2804), Organogenesis and [Cytodifferentiation](https://www.wikipathways.org/index.php/Pathway:WP2840).
Hair follicle development is a process dependent on epithelial-mesenchymal transitions orchestrated by many signaling pathways. Here we find one of three complex regulatory pathways assembled from a text mining approach portraying the development of this key mammal-specific structure.hair follicle cellCL:0002559Cell Type18593557PubMedHair follicle stem cells are specified and function in early skin morphogenesis.Cell Stem Cell2008Nowak JAPolak LPasolli HAFuchs E23133399PubMedTrps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.PLoS Genet201223133399PubMedTrps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.PLoS Genet201223133399PubMedTrps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.PLoS Genet2012Fantauzzo KAKurban MLevy BChristiano AM17376426PubMedLocalization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs.Dev Biol2007Hammerschmidt BSchlake Tregulatory pathwayPW:0000004Pathway Ontology