This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. This overview differentiates between the three primary germ cell layers (ectoderm-outer layer, endoderm-inner layer, mesoderm-middle layer), which are formed in the earliest state of embryonic development and give rise to different tissue types. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2848 CPTAC Assay Portal]dcehttp://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392Type your comment herehttp://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcsType your comment herehttp://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392Type your comment heref80abatraumatic neurosisDOID:2055Human Disease Ontologyastrocyte of the spinal cordCL:0002606Cell Ontologystem cellCL:0000034Cell Ontologyspinal cord diseaseDOID:319Human Disease Ontologyregulatory pathwayPW:0000004Pathway Ontologygrowth factor signaling pathwayPW:0000168Pathway Ontology21673720PubMedRepertoire of microglial and macrophage responses after spinal cord injury.Nat Rev Neurosci2011David SKroner A21771809PubMedInterplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development.Development2011Poulain MOber EA23045704PubMedTrisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.Proc Natl Acad Sci U S A2012Chou STByrska-Bishop MTober JMYao YVandorn DOpalinska JBMills JAChoi JKSpeck NAGadue PHardison RCNemiroff RLFrench DLWeiss MJ