Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators. f65 f65 e8c e8c e8c e8c e8c http://www.google.com/patents/CA2862140A1?cl=en Patented derivative of Pyrimido[4,5-b]indole e8c cca monocyte CL:0000576 Cell Type erythrocyte CL:0000232 Cell Type myeloblast CL:0000835 Cell Type basophil CL:0000767 Cell Type Interleukin mediated signaling pathway PW:0000512 Pathway Ontology peripheral blood stem cell CL:0002246 Cell Type megakaryocyte CL:0000556 Cell Type 22617791 PubMed MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia 2012 Zhang L Sankaran VG Lodish HF common myeloid progenitor CL:0000049 Cell Type 20549139 PubMed The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Braz J Med Biol Res 2010 20549139 PubMed The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Braz J Med Biol Res 2010 20549139 PubMed The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Braz J Med Biol Res 2010 Slavov SN Gimenes Teixeira HL Rego EM platelet CL:0000233 Cell Type 24766805 PubMed Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 2014 24766805 PubMed Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 2014 Riddell J Gazit R Garrison BS Guo G Saadatpour A Mandal PK Ebina W Volchkov P Yuan GC Orkin SH Rossi DJ hematopoietic stem cell CL:0000037 Cell Type neutrophil CL:0000775 Cell Type eosinophil CL:0000771 Cell Type