Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from [www.synapse.org](https://www.synapse.org/#!Synapse:syn1773109). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2853). aef e26 e32 dde fff c12 c8d These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). 18403408 PubMed Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 2008 Lewis SL Khoo PL De Young RA Steiner K Wilcock C Mukhopadhyay M Westphal H Jamieson RV Robb L Tam PP 23154981 PubMed The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells. Genes Dev. 2012 Tsuneyoshi Tan Poobalan Sumi Nakatsuji Suemori Dunn 23592794 PubMed MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7 Genes Dev 2013 Chappell Sun Singh Dalton 20805471 PubMed Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci USA 2010 Putzke Rothman 21741376 PubMed Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs Developmental Biology 2011 Kim Yoon Chuong Oyolu Wills Gupta Baker 22960178 PubMed FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun. 2012 Sui Mfopou Geens Sermon Bouwens 19544440 PubMed Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 2009 Bourillot Aksoy Schreiber Wianny Schulz Hummel Hubner Savatier regulatory pathway PW:0000004 Pathway Ontology 24823357 PubMed Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. Molecules and Cells 2014 Kang Won Rhee Ro 15542856 PubMed Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Mol Cell Biol. 2004 Futaki Hayashi Emoto Weber Sekiguchi