Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2858 CPTAC Assay Portal] fdc fa7 d0b c89 b88 b8b dd4 cd7 e6f These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in mesoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). These interactions were obtained by identifying all endoderm-mesodermal expression restricted genes and finding those targetted by miR-124. Among these 125 targets, 14 were highly induced in endoderm versus ectoderm (>4 fold, p<0.001). regulatory pathway PW:0000004 Pathway Ontology 19825829 PubMed Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. 23123965 PubMed Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development 16973150 PubMed Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. 19666824 PubMed Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis 16258936 PubMed Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development 2006 Van Hateren, N., Shenton, T., Borycki, A.-G 23643939 PubMed Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from embryonic stem cells. 23677624 PubMed Hedgehog and Gli signaling in embryonic mammary gland development. 22007134 PubMed HESX1- and TCF3-mediated repression of Wnt/خ²-catenin targets is required for normal development of the anterior forebrain 23022961 PubMed Beyond cell adhesion: the role of armadillo proteins in the heart.