The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2873 CPTAC Assay Portal] c03 d11 d9b c06 Omeprazole, TCDD, PCB Omeprazole, TCDD, PCB Omeprazole, TCDD, PCB Omeprazole, TCDD, PCB a7b fc2 a7b fc2 d2d feb feb e72 a7b feb a7b d2d e72 fc2 feb feb d2d e65 a7b a2e ef9 feb feb feb a2e ef9 e72 fc2 a7b a2e ef9 fc2 a2e ef9 e35 a2e ef9 b16 ef9 feb dc0 feb a2e ef9 e72 fc2 d47 c85 feb fc2 ef9 a2e e72 regulatory pathway PW:0000004 Pathway Ontology aryl hydrocarbon receptor signaling pathway PW:0000370 Pathway Ontology 9099515 PubMed Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997 Rowlands JC Gustafsson JA 18848820 PubMed Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem Pharmacol 2009 Haarmann-Stemmann T Bothe H Abel J 16545780 PubMed Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem Pharmacol 2006 Bock KW Köhle C 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 21420387 PubMed From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol 2011 Bock KW 20619336 PubMed Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Toxicol In Vitro 2010 Le Vee M Jouan E Fardel O 16289099 PubMed Over-production of IFN-gamma and IL-12 in AhR-null mice. FEBS Lett 2005 Rodríguez-Sosa M Elizondo G López-Durán RM Rivera I Gonzalez FJ Vega L 12573486 PubMed Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 2003 Mimura J Fujii-Kuriyama Y 15598615 PubMed Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environ Health Perspect 2004 Vezina CM Walker NJ Olson JR 17944540 PubMed AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem Res Toxicol 2007 Hockley SL Arlt VM Brewer D Te Poele R Workman P Giddings I Phillips DH 18288955 PubMed Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab 2008 Pavek P Dvorak Z 17266942 PubMed Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 2007 Köhle C Bock KW 17952121 PubMed TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene 2008 Weiss C Faust D Schreck I Ruff A Farwerck T Melenberg A Schneider S Oesch-Bartlomowicz B Zatloukalová J Vondrácek J Oesch F Dietrich C 15496506 PubMed 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin. Mol Pharmacol 2005 Marchand A Tomkiewicz C Marchandeau JP Boitier E Barouki R Garlatti M 15897893 PubMed TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene 2005 Weiss C Faust D Dürk H Kolluri SK Pelzer A Schneider S Dietrich C Oesch F Göttlicher M 11120824 PubMed The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol 2000 Jeon MS Esser C 21226706 PubMed The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization. Br J Haematol 2011 Lindsey S Papoutsakis ET