The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2873 CPTAC Assay Portal]c03d11d9bc06Omeprazole, TCDD, PCBOmeprazole, TCDD, PCBOmeprazole, TCDD, PCBOmeprazole, TCDD, PCBa7bfc2a7bfc2d2dfebfebe72a7bfeba7bd2de72fc2febfebd2de65a7ba2eef9febfebfeba2eef9e72fc2a7ba2eef9fc2a2eef9e35a2eef9b16ef9febdc0feba2eef9e72fc2d47c85febfc2ef9a2ee72regulatory pathwayPW:0000004Pathway Ontologyaryl hydrocarbon receptor signaling pathwayPW:0000370Pathway Ontology9099515PubMedAryl hydrocarbon receptor-mediated signal transduction.Crit Rev Toxicol1997Rowlands JCGustafsson JA18848820PubMedGrowth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.Biochem Pharmacol2009Haarmann-Stemmann TBothe HAbel J16545780PubMedAh receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.Biochem Pharmacol2006Bock KWKöhle C24261707PubMedPathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.Curr Drug Metab2013Fijten RRJennen DGvan Delft JH21420387PubMedFrom differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.Biochem Pharmacol2011Bock KW20619336PubMedInvolvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.Toxicol In Vitro2010Le Vee MJouan EFardel O16289099PubMedOver-production of IFN-gamma and IL-12 in AhR-null mice.FEBS Lett2005Rodríguez-Sosa MElizondo GLópez-Durán RMRivera IGonzalez FJVega L12573486PubMedFunctional role of AhR in the expression of toxic effects by TCDD.Biochim Biophys Acta2003Mimura JFujii-Kuriyama Y15598615PubMedSubchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.Environ Health Perspect2004Vezina CMWalker NJOlson JR17944540PubMedAHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.Chem Res Toxicol2007Hockley SLArlt VMBrewer DTe Poele RWorkman PGiddings IPhillips DH18288955PubMedXenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.Curr Drug Metab2008Pavek PDvorak Z17266942PubMedCoordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.Biochem Pharmacol2007Köhle CBock KW17952121PubMedTCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.Oncogene2008Weiss CFaust DSchreck IRuff AFarwerck TMelenberg ASchneider SOesch-Bartlomowicz BZatloukalová JVondrácek JOesch FDietrich C15496506PubMed2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.Mol Pharmacol2005Marchand ATomkiewicz CMarchandeau JPBoitier EBarouki RGarlatti M15897893PubMedTCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.Oncogene2005Weiss CFaust DDürk HKolluri SKPelzer ASchneider SDietrich COesch FGöttlicher M11120824PubMedThe murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.J Immunol2000Jeon MSEsser C21226706PubMedThe aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.Br J Haematol2011Lindsey SPapoutsakis ET